EOG834ZMK GO:0003924 27/100 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG834ZMK GO:0004871 27/100 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG834ZMK GO:0005525 27/100 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG834ZMK GO:0007186 25/100 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG834ZMK GO:0007264 23/100 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG834ZMK GO:0007266 2/100 Rho protein signal transduction biological_process "A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf] EOG834ZMK GO:0031683 2/100 G-protein beta/gamma-subunit complex binding molecular_function "Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw] EOG834ZMK GO:0031526 2/100 brush border membrane cellular_component "The portion of the plasma membrane surrounding the brush border." [GOC:mah] EOG834ZMK GO:0031234 2/100 extrinsic component of cytoplasmic side of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah] EOG834ZMK GO:0031752 2/100 D5 dopamine receptor binding molecular_function "Interacting selectively and non-covalently with a D5 dopamine receptor." [GOC:mah, GOC:nln] EOG834ZMK GO:0007188 2/100 adenylate cyclase-modulating G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194] EOG834ZMK GO:0005834 2/100 heterotrimeric G-protein complex cellular_component "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684] EOG834ZMK GO:0007369 1/100 gastrulation biological_process "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] EOG834ZMK GO:0010004 1/100 gastrulation involving germ band extension biological_process "A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG834ZMK GO:0070252 1/100 actin-mediated cell contraction biological_process "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [GOC:mah] EOG834ZMK GO:0016476 1/100 regulation of embryonic cell shape biological_process "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb] EOG834ZMK GO:0003384 1/100 apical constriction involved in gastrulation biological_process "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG834ZMK GO:0005737 1/100 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG834ZMK GO:0005622 1/100 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG834ZMK GO:0046872 1/100 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai]