Domain arrangement Fusions Fissions Terminal losses Terminal emergences Single domain losses Single domain emergences PF00005 0 1 0 0 0 0 PF00005 PF12848 0 1 0 0 0 0 PF00008 0 1 0 0 0 0 PF00008 PF12661 0 1 0 0 0 0 PF00010 PF14598 1 0 0 0 0 0 PF00023 PF07525 1 0 0 0 0 0 PF00023 PF13637 1 0 0 0 0 0 PF00041 PF07679 1 0 0 0 0 0 PF00076 PF14327 0 0 1 0 0 0 PF00089 0 1 0 0 0 0 PF00090 0 1 0 0 0 0 PF00094 0 1 0 0 0 0 PF00096 PF12874 PF13894 1 0 0 0 0 0 PF00097 PF01485 1 0 0 0 0 0 PF00098 PF00665 1 0 0 0 0 0 PF00130 PF00168 1 0 0 0 0 0 PF00130 PF00781 1 0 1 0 0 0 PF00149 0 1 0 0 0 0 PF00156 0 1 0 0 0 0 PF00169 PF00022 1 0 0 0 0 0 PF00169 PF00784 1 0 0 0 0 0 PF00183 0 1 0 0 0 0 PF00211 0 1 0 0 0 0 PF00215 0 1 0 0 0 0 PF00270 0 1 0 0 0 0 PF00270 PF00271 PF02889 1 0 0 0 0 0 PF00271 PF16124 PF09382 PF00570 0 1 0 0 0 0 PF00300 0 1 0 0 0 0 PF00307 PF12130 1 0 0 0 0 0 PF00310 0 0 5 0 0 0 PF00350 PF01031 0 0 3 0 0 0 PF00373 PF09380 PF00769 0 1 0 0 0 0 PF00397 0 1 0 0 0 0 PF00400 PF16300 0 1 0 0 0 0 PF00439 PF01426 1 0 0 0 0 0 PF00454 PF00787 1 0 0 0 0 0 PF00454 PF02260 0 1 0 0 0 0 PF00462 PF07992 1 0 0 0 0 0 PF00493 0 1 0 0 0 0 PF00521 0 0 4 0 0 0 PF00531 0 1 0 0 0 0 PF00554 PF16179 PF12796 1 0 0 0 0 0 PF00611 0 1 0 0 0 0 PF00620 0 1 0 0 0 0 PF00628 PF00536 1 0 0 0 0 0 PF00630 PF01436 1 0 0 0 0 0 PF00658 PF00632 0 1 0 0 0 0 PF00664 PF00005 PF00664 1 0 0 0 0 0 PF00675 0 1 5 0 0 0 PF00676 PF02779 PF16870 0 1 0 0 0 0 PF00736 0 0 1 0 0 0 PF00787 PF13855 1 0 0 0 0 0 PF00790 PF01363 0 1 0 0 0 0 PF00791 0 1 2 0 0 0 PF00856 0 1 0 0 0 0 PF01073 0 0 0 0 1 0 PF01347 PF09172 0 1 0 0 0 0 PF01369 0 1 0 0 0 0 PF01388 0 1 0 0 0 0 PF01391 0 1 0 0 0 0 PF01398 0 1 0 0 0 0 PF01413 0 1 0 0 0 0 PF01591 0 1 0 0 0 0 PF01612 0 1 0 0 0 0 PF01749 PF00514 0 0 1 0 0 0 PF01799 PF00941 0 0 3 0 0 0 PF01833 PF16423 0 1 0 0 0 0 PF01835 PF07703 0 0 7 0 0 0 PF01846 0 1 0 0 0 0 PF01927 0 1 0 0 0 0 PF02055 0 0 1 0 0 0 PF02141 PF03455 0 1 0 0 0 0 PF02157 0 0 0 0 1 0 PF02194 0 0 3 0 0 0 PF02204 0 0 2 0 0 0 PF02210 0 1 0 0 0 0 PF02259 0 1 0 0 0 0 PF02260 0 0 2 0 0 0 PF02460 0 1 0 0 0 0 PF02518 0 1 4 0 0 0 PF02668 0 1 0 0 0 0 PF02709 0 1 0 0 0 0 PF02770 0 1 3 0 0 0 PF02771 0 1 0 0 0 0 PF02874 0 0 5 0 0 0 PF02893 0 1 0 0 0 0 PF03066 0 0 0 0 1 0 PF03372 PF00078 1 0 0 0 0 0 PF03456 0 1 0 0 0 0 PF03577 0 0 0 0 1 0 PF03657 0 0 0 0 1 0 PF03712 0 0 3 0 0 0 PF03821 0 0 0 0 1 0 PF04152 0 1 0 0 0 0 PF04300 0 1 0 0 0 0 PF04500 PF10551 1 0 0 0 0 0 PF04564 0 1 0 0 0 0 PF04774 0 0 1 0 0 0 PF04849 0 1 0 0 0 0 PF04904 0 1 0 0 0 0 PF04905 0 1 0 0 0 0 PF04916 0 0 0 0 1 0 PF04937 PF05699 1 0 0 0 0 0 PF05187 0 0 1 0 0 0 PF05193 0 1 0 0 0 0 PF05383 PF00076 1 0 1 0 0 0 PF05773 PF00270 PF00271 PF04408 PF07717 1 0 0 0 0 0 PF05986 0 1 0 0 0 0 PF06155 0 1 0 0 0 0 PF06470 PF02463 1 0 0 0 0 0 PF06825 0 0 0 0 1 0 PF07530 PF14529 1 0 0 0 0 0 PF07647 0 1 0 0 0 0 PF07700 PF07701 0 1 0 0 0 0 PF07776 PF13894 PF00096 PF13912 1 0 0 0 0 0 PF07928 0 0 1 0 0 0 PF08066 PF01612 0 0 1 0 0 0 PF08146 0 0 1 0 0 0 PF08148 0 0 3 0 0 0 PF08314 0 1 0 0 0 0 PF08393 PF12774 0 1 0 0 0 0 PF08397 PF00018 1 0 0 0 0 0 PF08515 PF07714 0 0 1 0 0 0 PF08544 0 1 0 0 0 0 PF08676 0 1 0 0 0 0 PF08953 0 1 0 0 0 0 PF08969 0 1 0 0 0 0 PF09138 0 0 0 0 1 0 PF09273 0 1 0 0 0 0 PF09379 0 1 0 0 0 0 PF09379 PF00373 0 1 0 0 0 0 PF09380 PF08736 0 1 0 0 0 0 PF10195 0 0 0 0 1 0 PF10291 0 1 0 0 0 0 PF10408 0 1 0 0 0 0 PF10509 PF00288 0 1 0 0 0 0 PF10996 0 0 1 0 0 0 PF11262 0 0 2 0 0 0 PF11547 0 1 0 0 0 0 PF11935 0 0 1 0 0 0 PF12031 0 1 0 0 0 0 PF12032 0 1 0 0 0 0 PF12166 0 1 0 0 0 0 PF12210 0 1 0 0 0 0 PF12349 0 1 1 0 0 0 PF12448 0 1 0 0 0 0 PF12460 0 1 0 0 0 0 PF12717 0 1 0 0 0 0 PF12774 0 0 1 0 0 0 PF12775 PF12780 PF12777 PF12781 PF03028 0 1 7 0 0 0 PF12783 0 1 0 0 0 0 PF12796 PF13637 PF07525 1 0 0 0 0 0 PF12796 PF13637 PF12796 PF13637 1 0 0 0 0 0 PF12874 PF13909 1 0 0 0 0 0 PF12922 0 1 0 0 0 0 PF12937 0 1 0 0 0 0 PF13193 0 1 3 0 0 0 PF13300 0 0 0 0 1 0 PF13374 0 1 0 0 0 0 PF13424 0 1 0 0 0 0 PF13499 PF13405 1 0 0 0 0 0 PF13589 PF01119 0 1 0 0 0 0 PF13672 0 0 0 0 1 0 PF13733 0 1 0 0 0 0 PF13793 0 1 0 0 0 0 PF13820 0 0 0 0 1 0 PF13855 PF14580 1 0 0 0 0 0 PF13912 PF12874 PF13894 1 0 0 0 0 0 PF13921 0 0 1 0 0 0 PF13927 PF07679 PF00041 PF13927 1 0 0 0 0 0 PF14214 PF05970 1 0 0 0 0 0 PF14223 PF00098 1 0 0 0 0 0 PF14500 0 1 0 0 0 0 PF14551 PF17207 0 1 0 0 0 0 PF14572 0 1 0 0 0 0 PF14688 0 0 1 0 0 0 PF15013 0 0 0 0 1 0 PF15410 0 1 0 0 0 0 PF15492 0 1 0 0 0 0 PF15787 0 0 1 0 0 0 PF15917 0 1 0 0 0 0 PF16016 0 1 0 0 0 0 PF16078 0 1 0 0 0 0 PF16134 0 0 2 0 0 0 PF16177 PF00501 0 1 0 0 0 0 PF16184 0 1 0 0 0 0 PF16192 0 0 2 0 0 0 PF16213 0 0 6 0 0 0 PF16401 0 0 0 0 1 0 PF16422 0 1 0 0 0 0 PF16496 0 0 4 0 0 0 PF16533 0 1 0 0 0 0