EOG8D294J	GO:0009416	1/51	response to light stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
EOG8D294J	GO:0004535	1/51	poly(A)-specific ribonuclease activity	molecular_function	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]
EOG8D294J	GO:0030014	1/51	CCR4-NOT complex	cellular_component	"The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins." [GOC:sart, PMID:11113136]
EOG8D294J	GO:0005811	1/51	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8D294J	GO:0045475	1/51	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8D294J	GO:0005737	1/51	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8D294J	GO:0000289	1/51	nuclear-transcribed mRNA poly(A) tail shortening	biological_process	"Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc]
EOG8D294G	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8D294G	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XPSZV	GO:0003677	197/409	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XPSZV	GO:0000786	197/409	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8XPSZV	GO:0006334	197/409	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8XPSZV	GO:0005634	196/409	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XPSZV	GO:0032008	25/409	positive regulation of TOR signaling	biological_process	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8XPSZV	GO:0071230	25/409	cellular response to amino acid stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:mah]
EOG8XPSZV	GO:0032439	22/409	endosome localization	biological_process	"Any process in which endosomes are transported to, and/or maintained in, a specific location within the cell." [GOC:ecd]
EOG8XPSZV	GO:0007040	22/409	lysosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]
EOG8XPSZV	GO:0001919	22/409	regulation of receptor recycling	biological_process	"Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add]
EOG8XPSZV	GO:0071986	22/409	Ragulator complex	cellular_component	"A protein complex that contains MAPKSP1 (MP1, Map2k1ip1), ROBLD3 (p14, Mapbpip), C11orf59 (p18), LAMTOR4 and LAMTOR5. The complex is anchored to lipid rafts in late endosome membranes via C11orf59, recruits mTORC1 to lysosomal membranes in amino acid signaling to mTORC1, constitutes a guanine nucleotide exchange factor (GEF) for the Rag GTPases, and is also involved in ERK/MAPK signaling." [GOC:lb, PMID:19177150, PMID:20381137, PMID:22980980]
EOG8XPSZV	GO:0042632	22/409	cholesterol homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]
EOG8XPSZV	GO:0043410	22/409	positive regulation of MAPK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]
EOG8XPSZV	GO:0031902	3/409	late endosome membrane	cellular_component	"The lipid bilayer surrounding a late endosome." [GOC:pz]
EOG8XPSZV	GO:0003964	1/409	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8XPSZV	GO:0003723	1/409	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8WDGVH	GO:0035556	5/22	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8WDGVH	GO:0004629	1/22	phospholipase C activity	molecular_function	"Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]
EOG8WDGVH	GO:0007268	1/22	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8WDGVH	GO:0004871	1/22	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8XSP5B	GO:0000398	1/83	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8XSP5B	GO:0071013	1/83	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8XSP5B	GO:0071011	1/83	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8D294P	GO:0016757	17/76	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8W9MK0	GO:0005525	26/97	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8W9MK0	GO:0007264	26/97	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8W9MK0	GO:0015031	23/97	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8W9MK0	GO:0004767	1/97	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8W9MK0	GO:0001738	1/97	morphogenesis of a polarized epithelium	biological_process	"The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]
EOG8W9MK0	GO:0055037	1/97	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG8W9MK0	GO:0005737	1/97	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8W9MK0	GO:0043025	1/97	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8W9MK0	GO:0045202	1/97	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG879HP7	GO:0016020	1/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG879HP7	GO:0046873	1/5	metal ion transmembrane transporter activity	molecular_function	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]
EOG879HP7	GO:0005615	1/5	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8SXQSC	GO:0016192	2/112	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8SXQSC	GO:0006886	2/112	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8SXQSC	GO:0030117	1/112	membrane coat	cellular_component	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]
EOG8SXQSC	GO:0003677	1/112	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8SXQSC	GO:0031513	1/112	nonmotile primary cilium	cellular_component	"A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998]
EOG8SXQSC	GO:0042384	1/112	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8SXQSC	GO:0030990	1/112	intraciliary transport particle	cellular_component	"A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166]
EOG8SXQSC	GO:0007018	1/112	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8SXQSC	GO:0005871	1/112	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8SXQSC	GO:0035058	1/112	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG8SXQSC	GO:0004674	1/112	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8SXQSC	GO:0005524	1/112	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SXQSC	GO:0005929	1/112	cilium	cellular_component	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:kmv, GOC:vw, ISBN:0198547684]
EOG8SXQSC	GO:0005198	1/112	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8SXQSC	GO:0007275	1/112	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8WHC36	GO:0004601	1/27	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG88WFG5	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88WFG5	GO:0015171	2/5	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8SXQSQ	GO:0008270	6/40	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SXQSQ	GO:0005634	6/40	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SXQSQ	GO:0003676	1/40	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SXQSS	GO:0005887	1/78	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SXQSS	GO:0046331	1/78	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8VT8DX	GO:0006811	1/19	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8VT8DX	GO:0016021	1/19	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG854CFH	GO:0005200	1/4	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG854CFH	GO:0005874	1/4	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG854CFH	GO:0005525	1/4	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG854CFH	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG854CFH	GO:0008270	1/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG854CFH	GO:0007017	1/4	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG879HPP	GO:0005319	2/9	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG854CF1	GO:0003677	3/9	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG854CF1	GO:0003682	3/9	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8J6V6D	GO:0016616	1/4	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8J6V6D	GO:0005975	1/4	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8Q2GXV	GO:0003676	1/3	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q2GXV	GO:0046872	1/3	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NP9JF	GO:0016787	1/91	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8Q2GXK	GO:0005215	2/5	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8Q2GXK	GO:0016020	2/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Q2GXH	GO:0007229	4/8	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG8Q2GXH	GO:0007155	4/8	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8Q2GXH	GO:0008305	4/8	integrin complex	cellular_component	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]
EOG8W9MKJ	GO:0022857	2/5	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8W9MKJ	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W9MKJ	GO:0008643	1/5	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8RR8XB	GO:0005737	1/114	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RR8XB	GO:0050839	1/114	cell adhesion molecule binding	molecular_function	"Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai]
EOG8RR8XB	GO:0016081	1/114	synaptic vesicle docking	biological_process	"The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342]
EOG8RR8XB	GO:0016080	1/114	synaptic vesicle targeting	biological_process	"The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:mah]
EOG8RR8XB	GO:0007163	1/114	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8RR8XB	GO:0007269	1/114	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8RR8XB	GO:0048749	1/114	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8B5RJW	GO:0003777	4/33	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8B5RJW	GO:0007018	4/33	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8B5RJW	GO:0030286	3/33	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8B5RJW	GO:0005524	3/33	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8B5RJW	GO:0016887	2/33	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8DV822	GO:0016021	12/30	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XSP55	GO:0008270	1/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DV820	GO:0006886	1/102	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8DV820	GO:0031513	1/102	nonmotile primary cilium	cellular_component	"A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998]
EOG8DV820	GO:0016192	1/102	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8DV820	GO:0035058	1/102	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG8DV820	GO:0042384	1/102	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8WSZSV	GO:0003964	1/4	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8WSZSV	GO:0004519	1/4	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8FJBQC	GO:0015031	25/92	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8FJBQB	GO:0005524	22/94	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8FJBQB	GO:0006183	22/94	GTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8FJBQB	GO:0004550	22/94	nucleoside diphosphate kinase activity	molecular_function	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]
EOG8FJBQB	GO:0006241	22/94	CTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]
EOG8FJBQB	GO:0006228	22/94	UTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732]
EOG8FJBQB	GO:0003899	1/94	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8FJBQB	GO:0005634	1/94	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FJBQB	GO:0006351	1/94	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8C5FZV	GO:0016477	1/20	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG8C5FZV	GO:0007015	1/20	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8C5FZV	GO:0007155	1/20	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8C5FZV	GO:0007605	1/20	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8C5FZV	GO:0050954	1/20	sensory perception of mechanical stimulus	biological_process	"The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8C5FZV	GO:0016203	1/20	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG818F3C	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG818F3C	GO:0022857	2/5	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8C5FZR	GO:0016021	59/197	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C5FZR	GO:0022857	55/197	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8C5FZR	GO:0055085	4/197	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8C5FZR	GO:0008643	1/197	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8C5FZN	GO:0004672	1/95	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8C5FZN	GO:0005524	1/95	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZCWN7	GO:0043565	1/4	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8ZCWN7	GO:0005634	1/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZCWN7	GO:0003700	1/4	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8T1M39	GO:0008270	7/43	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KM1GW	GO:0005524	2/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KM1GW	GO:0016887	2/5	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8T1M34	GO:0004843	29/94	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG8T1M34	GO:0006511	29/94	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8T1M34	GO:0005622	28/94	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8T1M34	GO:0016579	1/94	protein deubiquitination	biological_process	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]
EOG8T1M34	GO:0004221	1/94	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG8T1M34	GO:0005875	1/94	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8RFPB1	GO:0007017	1/5	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8RFPB1	GO:0051258	1/5	protein polymerization	biological_process	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
EOG8RFPB1	GO:0005200	1/5	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8RFPB1	GO:0003924	1/5	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8RFPB1	GO:0005525	1/5	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8RFPB1	GO:0005874	1/5	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8X6FR9	GO:0004930	1/3	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8X6FR9	GO:0016021	1/3	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87DCWX	GO:0016787	125/753	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG87DCWX	GO:0003990	29/753	acetylcholinesterase activity	molecular_function	"Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
EOG87DCWX	GO:0052689	10/753	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG87DCWX	GO:0004104	5/753	cholinesterase activity	molecular_function	"Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8]
EOG87DCWX	GO:0005576	3/753	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG87DCWX	GO:0005524	1/753	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87DCWX	GO:0006730	1/753	one-carbon metabolic process	biological_process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
EOG87DCWX	GO:0004013	1/753	adenosylhomocysteinase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1]
EOG87DCWX	GO:0003677	1/753	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG87DCWX	GO:0016021	1/753	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87DCWX	GO:0006260	1/753	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG812PM0	GO:0004222	2/5	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG812PM0	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X6FRF	GO:0005549	1/3	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8X6FRF	GO:0006810	1/3	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8WSZS6	GO:0004984	18/33	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8WSZS6	GO:0005549	18/33	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8WSZS6	GO:0016021	13/33	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WSZS6	GO:0004930	13/33	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8WSZS6	GO:0016020	5/33	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG86Q96Z	GO:0005622	2/5	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG86Q96Z	GO:0004725	2/5	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG86Q96Z	GO:0051301	1/5	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8KH57V	GO:0007165	1/5	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8T1M3V	GO:0010507	1/72	negative regulation of autophagy	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8T1M3V	GO:0048812	1/72	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8KH57Z	GO:0004970	12/45	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8KH57Z	GO:0005234	12/45	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8KH57Z	GO:0016020	12/45	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG84J4Z8	GO:0016746	22/107	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG84J4Z8	GO:0005509	18/107	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG84J4Z8	GO:0005789	1/107	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG84J4Z8	GO:0000139	1/107	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG84J4Z8	GO:0047184	1/107	1-acylglycerophosphocholine O-acyltransferase activity	molecular_function	"Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN]
EOG84J4Z8	GO:0005794	1/107	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG84J4Z8	GO:0005783	1/107	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG84J4Z8	GO:0008654	1/107	phospholipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG84J4Z8	GO:0016021	1/107	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8MWBMX	GO:0005622	143/592	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8MWBMX	GO:0005215	143/592	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8MWBMX	GO:0022008	1/592	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8MWBMX	GO:0016787	1/592	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG86DPJ6	GO:0046872	1/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG86DPJ6	GO:0003676	1/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG86DPJ8	GO:0004252	2/4	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG86DPJ9	GO:0016021	7/45	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SR0C4	GO:0046872	59/198	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8SR0C4	GO:0004784	57/198	superoxide dismutase activity	molecular_function	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]
EOG8SR0C4	GO:0005737	11/198	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SR0C4	GO:0006801	4/198	superoxide metabolic process	biological_process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl]
EOG8SR0C4	GO:0055114	4/198	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8SR0C4	GO:0005507	2/198	copper ion binding	molecular_function	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]
EOG8SR0C4	GO:0008270	2/198	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SR0C4	GO:0019430	2/198	removal of superoxide radicals	biological_process	"Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [CHEBI:18421, GOC:jl]
EOG8SR0C4	GO:0006979	2/198	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8SR0C4	GO:0005615	1/198	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8SR0C4	GO:0016209	1/198	antioxidant activity	molecular_function	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
EOG8SR0C4	GO:0005777	1/198	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8SR0C4	GO:0007568	1/198	aging	biological_process	"A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death (GO:0016265) and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators]
EOG8SR0C4	GO:0042803	1/198	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8SR0C4	GO:0008340	1/198	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8SR0C4	GO:0009650	1/198	UV protection	biological_process	"Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml]
EOG89PDFN	GO:0005549	1/113	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8D55CJ	GO:0008532	5/138	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149]
EOG8D55CJ	GO:0016740	3/138	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8D55CJ	GO:0005506	1/138	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8D55CJ	GO:0007218	1/138	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8D55CJ	GO:0002121	1/138	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8D55CJ	GO:0008109	1/138	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.150]
EOG8D55CJ	GO:0020037	1/138	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8D55CJ	GO:0016705	1/138	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG86DPJR	GO:0008374	1/5	O-acyltransferase activity	molecular_function	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
EOG86DPJR	GO:0044255	1/5	cellular lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]
EOG88WFG2	GO:0005319	2/6	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG88PQ1C	GO:0035556	22/64	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG88PQ1C	GO:0045454	2/64	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG88PQ1C	GO:0008430	2/64	selenium binding	molecular_function	"Interacting selectively and non-covalently with selenium (Se)." [GOC:ai]
EOG88PQ1G	GO:0004222	2/5	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG88PQ1G	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG82RGPB	GO:0016020	1/4	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82RGPB	GO:0005234	1/4	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG82RGPB	GO:0004970	1/4	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG82RGPD	GO:0005840	4/79	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG82RGPD	GO:0006412	3/79	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG82RGPD	GO:0003735	3/79	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG82RGPD	GO:0015074	1/79	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG82RGPD	GO:0003677	1/79	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG82RGPD	GO:0006310	1/79	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG84J4ZX	GO:0046872	52/224	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84J4ZX	GO:0016787	45/224	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG84J4ZX	GO:0004177	13/224	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG84J4ZX	GO:0005829	1/224	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG84J4ZX	GO:0006508	1/224	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG84J4ZX	GO:0022008	1/224	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84J4ZX	GO:0070006	1/224	metalloaminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG84J4ZT	GO:0006909	1/84	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG84J4ZT	GO:0005884	1/84	actin filament	cellular_component	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]
EOG84J4ZT	GO:0005737	1/84	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84J4ZT	GO:0016021	1/84	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84J4ZT	GO:0003779	1/84	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG84J4ZT	GO:0005829	1/84	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG84J4ZT	GO:0030041	1/84	actin filament polymerization	biological_process	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG84J4ZT	GO:0005576	1/84	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG84J4ZT	GO:0046872	1/84	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84J4ZT	GO:0005215	1/84	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8FTZDC	GO:0008270	20/93	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FTZDC	GO:0051371	3/93	muscle alpha-actinin binding	molecular_function	"Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc." [PMID:10984498, PMID:11699871, PMID:15014165]
EOG8FTZDC	GO:0001952	3/93	regulation of cell-matrix adhesion	biological_process	"Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]
EOG8FTZDC	GO:0015629	3/93	actin cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
EOG8FTZDC	GO:0030018	1/93	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8FTZDC	GO:0005515	1/93	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FTZDC	GO:0003779	1/93	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8FTZDC	GO:0005927	1/93	muscle tendon junction	cellular_component	"A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007]
EOG8FTZDC	GO:0030239	1/93	myofibril assembly	biological_process	"Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]
EOG8FTZDC	GO:0061061	1/93	muscle structure development	biological_process	"The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]
EOG8V71XM	GO:0016491	1/39	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG805VGD	GO:0022857	1/3	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG805VGD	GO:0016021	1/3	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V71XQ	GO:0004190	2/10	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8ZKN28	GO:0008168	24/162	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8ZKN28	GO:0030798	11/162	trans-aconitate 2-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972]
EOG8ZKN21	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZKN21	GO:0055085	2/5	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8QNQBP	GO:0005581	1/64	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG805VG7	GO:0005506	679/2000	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG805VG7	GO:0020037	679/2000	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG805VG7	GO:0016705	629/2000	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG805VG7	GO:0004497	607/2000	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG805VG7	GO:0070330	31/2000	aromatase activity	molecular_function	"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
EOG805VG7	GO:0005789	25/2000	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG805VG7	GO:0050591	15/2000	quinine 3-monooxygenase activity	molecular_function	"Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152]
EOG805VG7	GO:0004796	4/2000	thromboxane-A synthase activity	molecular_function	"Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17140]
EOG805VG7	GO:0031000	2/2000	response to caffeine	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah]
EOG805VG7	GO:0009055	2/2000	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG805VG7	GO:0016712	2/2000	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
EOG805VG7	GO:0017085	2/2000	response to insecticide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]
EOG805VG7	GO:0006697	1/2000	ecdysone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732]
EOG805VG7	GO:0050829	1/2000	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG805VG7	GO:0030178	1/2000	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG805VG7	GO:0017143	1/2000	insecticide metabolic process	biological_process	"The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai]
EOG805VG7	GO:0046701	1/2000	insecticide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai]
EOG805VG7	GO:0022416	1/2000	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG805VG7	GO:0042742	1/2000	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG805VG7	GO:0048252	1/2000	lauric acid metabolic process	biological_process	"The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [CHEBI:30805, GOC:jid]
EOG805VG7	GO:0016020	1/2000	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG805VG7	GO:1901563	1/2000	response to camptothecin	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie]
EOG805VG7	GO:0018685	1/2000	alkane 1-monooxygenase activity	molecular_function	"Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3]
EOG805VG7	GO:0033777	1/2000	lithocholate 6beta-hydroxylase activity	molecular_function	"Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.13.94, RHEA:18860]
EOG805VG7	GO:0002118	1/2000	aggressive behavior	biological_process	"A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd]
EOG805VG7	GO:0046683	1/2000	response to organophosphorus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544]
EOG805VG7	GO:0035220	1/2000	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG805VG7	GO:0048638	1/2000	regulation of developmental growth	biological_process	"Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators]
EOG805VG7	GO:0040040	1/2000	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG805VG7	GO:0046680	1/2000	response to DDT	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544]
EOG805VG7	GO:0046689	1/2000	response to mercury ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai]
EOG8KSS2Z	GO:0007155	1/4	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8KSS2Z	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86T5FP	GO:0005272	12/78	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG86T5FP	GO:0016021	8/78	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86T5FP	GO:0016020	4/78	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG86T5FW	GO:0005829	21/81	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG86T5FW	GO:0004842	21/81	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG86T5FW	GO:0005739	21/81	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG86T5FW	GO:0008270	20/81	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG86T5FW	GO:0007283	1/81	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG86T5FW	GO:0010637	1/81	negative regulation of mitochondrial fusion	biological_process	"Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]
EOG86T5FW	GO:1900407	1/81	regulation of cellular response to oxidative stress	biological_process	"Any process that modulates the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie]
EOG86T5FW	GO:0051865	1/81	protein autoubiquitination	biological_process	"The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]
EOG86T5FW	GO:0008344	1/81	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG86T5FW	GO:0005737	1/81	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86T5FW	GO:0048078	1/81	positive regulation of compound eye pigmentation	biological_process	"Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid]
EOG86T5FW	GO:0070050	1/81	neuron cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah]
EOG86T5FW	GO:0055069	1/81	zinc ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
EOG86T5FW	GO:0046329	1/81	negative regulation of JNK cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG86T5FW	GO:0016021	1/81	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86T5FW	GO:0030382	1/81	sperm mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144]
EOG86T5FW	GO:0000266	1/81	mitochondrial fission	biological_process	"The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]
EOG86T5FW	GO:0006979	1/81	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG86T5FW	GO:0010821	1/81	regulation of mitochondrion organization	biological_process	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]
EOG86T5FW	GO:0016567	1/81	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG86T5FW	GO:0007005	1/81	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG86T5FW	GO:0055085	1/81	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG86T5FW	GO:0000422	1/81	mitophagy	biological_process	"The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]
EOG86T5FW	GO:0042787	1/81	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological_process	"The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]
EOG86T5FW	GO:0090141	1/81	positive regulation of mitochondrial fission	biological_process	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG86T5FW	GO:0048477	1/81	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8T7BJ1	GO:0022891	16/72	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8T7BJ1	GO:0016021	16/72	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8T7BJ1	GO:0008643	4/72	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8T7BJ1	GO:0032440	3/72	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8NW235	GO:0042302	2/6	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8577P5	GO:0005506	34/71	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8577P5	GO:0020037	34/71	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8577P5	GO:0019825	34/71	oxygen binding	molecular_function	"Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl]
EOG8577P5	GO:0005344	22/71	oxygen transporter activity	molecular_function	"Enables the directed movement of oxygen into, out of or within a cell, or between cells." [GOC:ai]
EOG8577P5	GO:0015671	12/71	oxygen transport	biological_process	"The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8577P5	GO:0005833	4/71	hemoglobin complex	cellular_component	"An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group." [GOC:jl, ISBN:0198506732]
EOG8577P5	GO:0005576	4/71	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8C8B6N	GO:0003677	2/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8C8B6N	GO:0046872	1/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8C8B6N	GO:0008270	1/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8C8B6N	GO:0005634	1/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NP9KH	GO:0009649	1/23	entrainment of circadian clock	biological_process	"The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid]
EOG8NP9KH	GO:0010378	1/23	temperature compensation of the circadian clock	biological_process	"The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099]
EOG8J6V5P	GO:0008236	2/5	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8J6V5P	GO:0004180	1/5	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8P8J19	GO:0016021	3/8	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RR902	GO:0006814	2/4	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8RR902	GO:0006813	2/4	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8RR902	GO:0005890	2/4	sodium:potassium-exchanging ATPase complex	cellular_component	"Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732]
EOG8P8J13	GO:0042384	1/83	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8JWXVJ	GO:0005525	1/46	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8JWXVJ	GO:0003924	1/46	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG81K1SD	GO:0016747	1/5	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8R52JH	GO:0001104	4/18	RNA polymerase II transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8R52JH	GO:0016592	4/18	mediator complex	cellular_component	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
EOG8B5RKX	GO:0005741	2/5	mitochondrial outer membrane	cellular_component	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
EOG8B5RKX	GO:0055085	2/5	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8R52JN	GO:0007275	2/4	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8R52JN	GO:0016055	2/4	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG8R52JN	GO:0005578	2/4	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG8R52JV	GO:0003700	1/7	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8R52JV	GO:0003677	1/7	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8R52JV	GO:0043565	1/7	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8R52JV	GO:0005634	1/7	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8R52JV	GO:0006355	1/7	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8MPM44	GO:0005938	1/87	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8MPM44	GO:0005515	1/87	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8MPM44	GO:0045921	1/87	positive regulation of exocytosis	biological_process	"Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators]
EOG8MPM44	GO:0043234	1/87	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8MPM44	GO:0045177	1/87	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8MPM44	GO:0005737	1/87	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8MPM44	GO:0008017	1/87	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8B5RK6	GO:0006355	6/47	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8B5RK6	GO:0005634	6/47	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8B5RK6	GO:0004402	2/47	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8DBWVR	GO:0004850	58/135	uridine phosphorylase activity	molecular_function	"Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3]
EOG8DBWVR	GO:0005737	56/135	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8DBWVR	GO:0009166	56/135	nucleotide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]
EOG8DBWVR	GO:0009116	44/135	nucleoside metabolic process	biological_process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]
EOG8DBWVR	GO:0044206	15/135	UMP salvage	biological_process	"Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis." [GOC:ecd, PMID:15096496]
EOG8DBWVR	GO:0016763	1/135	transferase activity, transferring pentosyl groups	molecular_function	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8DBWVR	GO:0000123	1/135	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG8DBWVR	GO:0042332	1/135	gravitaxis	biological_process	"The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
EOG8MPM4C	GO:0080019	109/262	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8MPM4C	GO:0005737	1/262	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8MPM4C	GO:0050062	1/262	long-chain-fatty-acyl-CoA reductase activity	molecular_function	"Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH." [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN]
EOG8MPM4C	GO:0005509	1/262	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8MPM4C	GO:0016042	1/262	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8MPM4C	GO:0035002	1/262	liquid clearance, open tracheal system	biological_process	"The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352]
EOG8MPM4C	GO:0004043	1/262	L-aminoadipate-semialdehyde dehydrogenase activity	molecular_function	"Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31]
EOG8MPM4C	GO:0045177	1/262	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8MPM4C	GO:0035149	1/262	lumen formation, open tracheal system	biological_process	"Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
EOG8MPM4C	GO:0004623	1/262	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG8MPM4C	GO:0055114	1/262	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8P8J1Q	GO:0016301	1/33	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8MPM4X	GO:0055085	2/8	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8MPM4X	GO:0016021	2/8	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8R52J7	GO:0016021	1/3	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81K1S4	GO:0008270	26/90	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81K1S4	GO:0004842	23/90	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG81K1S4	GO:0007520	1/90	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG81K1S4	GO:0004623	1/90	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG81K1S4	GO:0032038	1/90	myosin II heavy chain binding	molecular_function	"Interacting selectively and non-covalently with a heavy chain of a myosin II complex." [GOC:mah]
EOG81K1S4	GO:0046872	1/90	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81K1S4	GO:0031430	1/90	M band	cellular_component	"The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194]
EOG81K1S4	GO:0030018	1/90	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG81K1S4	GO:0032033	1/90	myosin II light chain binding	molecular_function	"Interacting selectively and non-covalently with a light chain of a myosin II complex." [GOC:mah]
EOG81K1S4	GO:0046716	1/90	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG81K1S4	GO:0005737	1/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8J6V53	GO:0008270	2/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8J6V53	GO:0008237	2/4	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG87H83X	GO:0005524	27/105	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87H83X	GO:0004697	27/105	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG87H83X	GO:0035556	25/105	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG87H83X	GO:0046872	24/105	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG87H83X	GO:0005737	12/105	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87H83X	GO:0004674	1/105	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG87H83X	GO:0006468	1/105	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8935Z9	GO:0016021	1/66	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8935Z9	GO:0006147	1/66	guanine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators]
EOG8935Z9	GO:0008892	1/66	guanine deaminase activity	molecular_function	"Catalysis of the reaction: guanine + H2O = xanthine + NH3." [EC:3.5.4.3]
EOG8935Z9	GO:0008270	1/66	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8935Z9	GO:0005549	1/66	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8935Z9	GO:0000902	1/66	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG812PNB	GO:0003676	1/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG812PNB	GO:0016788	1/5	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG8935Z0	GO:0016757	10/54	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8935Z6	GO:0005581	2/5	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8935Z6	GO:0005201	1/5	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG8XWJF2	GO:0008299	22/108	isoprenoid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
EOG8XWJF2	GO:0005737	22/108	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XWJF2	GO:0005524	22/108	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8XWJF2	GO:0004496	22/108	mevalonate kinase activity	molecular_function	"Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+)." [EC:2.7.1.36, RHEA:17068]
EOG8DV815	GO:0018738	19/140	S-formylglutathione hydrolase activity	molecular_function	"Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+)." [EC:3.1.2.12, RHEA:14964]
EOG8DV815	GO:0046294	19/140	formaldehyde catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai]
EOG8DV815	GO:0052689	2/140	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG8DV819	GO:0005524	21/84	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8DV819	GO:0004674	20/84	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8DV819	GO:0004672	2/84	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8DV819	GO:0007274	1/84	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8DV819	GO:0043069	1/84	negative regulation of programmed cell death	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
EOG8DV819	GO:0006979	1/84	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8DV819	GO:0005739	1/84	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8DV819	GO:0010821	1/84	regulation of mitochondrion organization	biological_process	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]
EOG8DV819	GO:0000266	1/84	mitochondrial fission	biological_process	"The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]
EOG8DV819	GO:0005515	1/84	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8DV819	GO:0030382	1/84	sperm mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144]
EOG8DV819	GO:0035234	1/84	ectopic germ cell programmed cell death	biological_process	"Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944]
EOG8DV819	GO:0007005	1/84	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8DV819	GO:0000422	1/84	mitophagy	biological_process	"The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]
EOG8DV819	GO:0090141	1/84	positive regulation of mitochondrial fission	biological_process	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8DV819	GO:0048749	1/84	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8DV819	GO:0042787	1/84	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological_process	"The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]
EOG8DV819	GO:0005737	1/84	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8DV819	GO:0010637	1/84	negative regulation of mitochondrial fusion	biological_process	"Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]
EOG8DV819	GO:0043524	1/84	negative regulation of neuron apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
EOG8DV819	GO:0016006	1/84	Nebenkern	cellular_component	"A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma]
EOG8DV819	GO:0048078	1/84	positive regulation of compound eye pigmentation	biological_process	"Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid]
EOG81VNJS	GO:0005525	12/48	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG81VNJS	GO:0007264	12/48	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG81VNJR	GO:0016020	2/16	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG81VNJR	GO:0003824	2/16	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG803081	GO:0003839	43/99	gamma-glutamylcyclotransferase activity	molecular_function	"Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [EC:2.3.2.4]
EOG803081	GO:0006750	43/99	glutathione biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, GOC:al, GOC:pde, ISBN:0198506732]
EOG803081	GO:0005576	1/99	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG803081	GO:0042381	1/99	hemolymph coagulation	biological_process	"Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949]
EOG81VNJK	GO:0016301	2/95	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8T1M2P	GO:0003676	3/11	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80306V	GO:0008270	329/890	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80306V	GO:0004181	329/890	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG80306V	GO:0005319	8/890	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG80306V	GO:0005615	3/890	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG80306V	GO:0007586	1/890	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG80306V	GO:0022008	1/890	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG80306V	GO:0031982	1/890	vesicle	cellular_component	"Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz]
EOG80306V	GO:0004180	1/890	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG80306V	GO:0005515	1/890	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG80306V	GO:0005576	1/890	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG80306V	GO:0016021	1/890	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80306V	GO:0004930	1/890	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8DV81R	GO:0016192	2/15	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8DV81R	GO:0016021	2/15	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DV81T	GO:0007498	1/40	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8D295D	GO:0016787	1/5	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8DV81C	GO:0016740	2/140	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8XWJFC	GO:0005549	2/52	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8VT8CC	GO:0005524	2/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VT8CC	GO:0004672	1/5	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8VT8CC	GO:0004713	1/5	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG80CKZ7	GO:0016021	3/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80CKZ7	GO:0007155	3/9	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG812PN7	GO:0016491	2/5	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8NZX9J	GO:0016021	6/19	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NZX9J	GO:0022857	4/19	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8NZX9J	GO:0022891	2/19	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8NZX9J	GO:0008643	1/19	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8D55BN	GO:0004222	86/312	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8D55BN	GO:0006508	2/312	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8D55BN	GO:0004175	2/312	endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8D55BN	GO:0016021	1/312	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D55BN	GO:0016529	1/312	sarcoplasmic reticulum	cellular_component	"A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage." [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684]
EOG8D55BN	GO:0005615	1/312	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8Z91CT	GO:0043565	37/124	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8Z91CT	GO:0003700	37/124	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z91CT	GO:0005634	30/124	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z91CT	GO:0032504	1/124	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8Z91CT	GO:0005615	1/124	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8Z91CT	GO:0030154	1/124	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8Z91CT	GO:0007399	1/124	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8Z91CT	GO:0006351	1/124	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8QC3MR	GO:0006355	2/5	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8QC3MR	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80P6NF	GO:0016021	97/327	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6NF	GO:0004995	41/327	tachykinin receptor activity	molecular_function	"Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:7639617, Wikipedia:Tachykinin]
EOG80P6NF	GO:0005886	40/327	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80P6NF	GO:0004983	35/327	neuropeptide Y receptor activity	molecular_function	"Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
EOG80P6NF	GO:0006935	33/327	chemotaxis	biological_process	"The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732]
EOG80P6NF	GO:0004950	33/327	chemokine receptor activity	molecular_function	"Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, http://en.wikipedia.org/wiki/Chemokine, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823]
EOG80P6NF	GO:0004930	13/327	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG80P6NF	GO:0050254	8/327	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG80P6NF	GO:0007186	3/327	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG80P6NF	GO:0008188	3/327	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG80P6NF	GO:0007218	3/327	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG80P6NF	GO:0007217	2/327	tachykinin receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor." [GOC:mah, PMID:14723970]
EOG80P6NF	GO:0005887	2/327	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6NF	GO:0050911	1/327	detection of chemical stimulus involved in sensory perception of smell	biological_process	"The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG80P6NF	GO:0050805	1/327	negative regulation of synaptic transmission	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
EOG80P6NF	GO:0042048	1/327	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG80P6NF	GO:0007166	1/327	cell surface receptor signaling pathway	biological_process	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
EOG80P6NF	GO:0004715	1/327	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG80P6NF	GO:0001653	1/327	peptide receptor activity	molecular_function	"Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl]
EOG80P6NF	GO:0002121	1/327	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8PVRDW	GO:0004252	2/5	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG80P6ND	GO:0016021	230/726	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6ND	GO:0022891	177/726	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG80P6ND	GO:0022857	38/726	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG80P6ND	GO:0008643	18/726	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG80P6ND	GO:0005886	18/726	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80P6ND	GO:0015771	15/726	trehalose transport	biological_process	"The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai]
EOG80P6ND	GO:0015574	15/726	trehalose transmembrane transporter activity	molecular_function	"Enables the transfer of trehalose from one side of the membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
EOG80P6ND	GO:0032440	8/726	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG80P6ND	GO:0016020	2/726	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG80P6ND	GO:0046427	1/726	positive regulation of JAK-STAT cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG8D55BV	GO:0016787	51/385	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8D55BV	GO:0052689	4/385	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG8D55BV	GO:0008152	2/385	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8D55BV	GO:0005576	1/385	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8D55BV	GO:0008340	1/385	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8D55BV	GO:0005737	1/385	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8D55BV	GO:0005811	1/385	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8D55BV	GO:0007476	1/385	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8D55BV	GO:0060179	1/385	male mating behavior	biological_process	"The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb]
EOG8D55BV	GO:0003990	1/385	acetylcholinesterase activity	molecular_function	"Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
EOG8D55BV	GO:0019915	1/385	lipid storage	biological_process	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]
EOG8D55BV	GO:0046683	1/385	response to organophosphorus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544]
EOG8H74SX	GO:0005549	3/43	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG86Q99B	GO:0005576	3/19	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Z91BM	GO:0005272	54/138	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8Z91BM	GO:0016021	53/138	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z91BM	GO:0051536	2/138	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8Z91BM	GO:0004252	2/138	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8Z91BM	GO:0016020	1/138	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Z91BM	GO:0000439	1/138	core TFIIH complex	cellular_component	"The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015]
EOG8Z91BM	GO:0006289	1/138	nucleotide-excision repair	biological_process	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]
EOG8Z91BM	GO:0006355	1/138	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8HMMT8	GO:0003723	1/16	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8HMMT8	GO:0003964	1/16	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8B8MV1	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8B8MV1	GO:0003700	2/5	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG88973M	GO:0005874	1/80	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG88973M	GO:0005525	1/80	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG88973M	GO:0004930	1/80	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG88973M	GO:0007017	1/80	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG88973M	GO:0016020	1/80	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HB10F	GO:0003777	1/7	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8HB10F	GO:0007018	1/7	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8HB10F	GO:0005871	1/7	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8HB10F	GO:0005524	1/7	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8HB10F	GO:0005874	1/7	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8H74S3	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8H74S3	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8H74S3	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8H74S1	GO:0003676	3/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8H74S1	GO:0046872	2/7	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8H74S1	GO:0005634	1/7	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8H74S1	GO:0008270	1/7	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8B8MX0	GO:0003899	22/57	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8B8MX0	GO:0003677	22/57	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8B8MX0	GO:0006351	21/57	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8B8MX0	GO:0006366	1/57	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8B8MX0	GO:0005736	1/57	DNA-directed RNA polymerase I complex	cellular_component	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8B8MX0	GO:0006383	1/57	transcription from RNA polymerase III promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH]
EOG8B8MX0	GO:0005666	1/57	DNA-directed RNA polymerase III complex	cellular_component	"RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8B8MX0	GO:0005665	1/57	DNA-directed RNA polymerase II, core complex	cellular_component	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8B8MX0	GO:0006360	1/57	transcription from RNA polymerase I promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
EOG88973R	GO:0046872	2/3	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG844P2D	GO:0006950	2/5	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8PVRD4	GO:0006685	2/3	sphingomyelin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732]
EOG8PVRD4	GO:0004767	2/3	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8WSZRQ	GO:0080019	5/14	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG82JR5H	GO:0016020	86/342	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82JR5H	GO:0008236	85/342	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG82JR5H	GO:0006508	7/342	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG82JR5H	GO:0008239	2/342	dipeptidyl-peptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]
EOG82JR5H	GO:0016491	1/342	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG82JR5H	GO:0005576	1/342	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8NKFB8	GO:0004089	104/367	carbonate dehydratase activity	molecular_function	"Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1]
EOG8NKFB8	GO:0006730	100/367	one-carbon metabolic process	biological_process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
EOG8NKFB8	GO:0008270	99/367	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NKFB8	GO:0031233	1/367	intrinsic component of external side of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah]
EOG8DRCV3	GO:0003676	3/252	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DRCV3	GO:0015074	3/252	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8DRCV3	GO:0003723	2/252	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8DRCV3	GO:0008270	2/252	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DRCV3	GO:0003964	2/252	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8DRCV3	GO:0004190	1/252	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG876NDB	GO:0005524	142/420	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG876NDB	GO:0006950	24/420	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG876NDB	GO:0005875	8/420	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG876NDB	GO:0009408	7/420	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG876NDB	GO:0032440	7/420	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG876NDB	GO:0001666	6/420	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG876NDB	GO:0035080	6/420	heat shock-mediated polytene chromosome puffing	biological_process	"The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus." [GOC:bf, PMID:12543962]
EOG876NDB	GO:0006986	4/420	response to unfolded protein	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl]
EOG876NDB	GO:0005811	3/420	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG876NDB	GO:0005515	2/420	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG876NDB	GO:0031427	2/420	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG876NDB	GO:0016021	1/420	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG876NDB	GO:0031209	1/420	SCAR complex	cellular_component	"A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:pg, PMID:12181570]
EOG876NDB	GO:0042594	1/420	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG876NDB	GO:0005634	1/420	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG876NDB	GO:0006909	1/420	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG876NDB	GO:0007528	1/420	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG876NDB	GO:0007010	1/420	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG876NDB	GO:0030866	1/420	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG876NDB	GO:0007520	1/420	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG876NDB	GO:0000902	1/420	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG876NDB	GO:0048471	1/420	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG876NDB	GO:0030031	1/420	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG876NDB	GO:0008407	1/420	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG876NDB	GO:0008360	1/420	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG876NDB	GO:0008340	1/420	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG876NDB	GO:0001764	1/420	neuron migration	biological_process	"The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]
EOG876NDB	GO:0005886	1/420	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG876NDB	GO:0007417	1/420	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG876NDB	GO:0030036	1/420	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG876NDB	GO:0007409	1/420	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG876NDB	GO:0022008	1/420	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8DRCV5	GO:0016021	1/3	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DRCV5	GO:0004930	1/3	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8DFS4C	GO:0046872	4/8	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DFS4C	GO:0003676	2/8	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89GNZ3	GO:0005890	79/270	sodium:potassium-exchanging ATPase complex	cellular_component	"Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732]
EOG89GNZ3	GO:0006813	78/270	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG89GNZ3	GO:0006814	76/270	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG89GNZ3	GO:0005886	3/270	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG89GNZ3	GO:0007605	2/270	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG89GNZ3	GO:0035725	2/270	sodium ion transmembrane transport	biological_process	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
EOG89GNZ3	GO:0006812	2/270	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG89GNZ3	GO:0035158	1/270	regulation of tube diameter, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584]
EOG89GNZ3	GO:0060857	1/270	establishment of glial blood-brain barrier	biological_process	"Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
EOG89GNZ3	GO:0005391	1/270	sodium:potassium-exchanging ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9]
EOG89GNZ3	GO:0035159	1/270	regulation of tube length, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
EOG89GNZ3	GO:0007424	1/270	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG89GNZ3	GO:0010996	1/270	response to auditory stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus." [GOC:BHF, GOC:dph, GOC:sl, GOC:tb]
EOG89GNZ3	GO:0005515	1/270	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG89GNZ3	GO:0035151	1/270	regulation of tube size, open tracheal system	biological_process	"Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]
EOG89GNZ3	GO:0019991	1/270	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG89GNZ3	GO:0005918	1/270	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG89GNZ3	GO:0061343	1/270	cell adhesion involved in heart morphogenesis	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
EOG89S8Q2	GO:0008270	13/25	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MSGBZ	GO:0005509	37/188	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8MSGBZ	GO:0016787	4/188	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8MSGBZ	GO:0030170	1/188	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8MSGBZ	GO:0008890	1/188	glycine C-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+)." [EC:2.3.1.29, RHEA:20739]
EOG8MSGBZ	GO:0097206	1/188	nephrocyte filtration	biological_process	"The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929]
EOG8MSGBZ	GO:0005875	1/188	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8MSGBZ	GO:0004714	1/188	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8MSGBZ	GO:0009058	1/188	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG8SFCKZ	GO:0006188	30/121	IMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732]
EOG8SFCKZ	GO:0003876	30/121	AMP deaminase activity	molecular_function	"Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6]
EOG8SFCKZ	GO:0005515	1/121	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VHNP7	GO:0004930	2/5	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8VHNP7	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GXJ2G	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82C0T2	GO:0055085	1/5	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG82C0T2	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80ZTDS	GO:0007476	1/92	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG80ZTDS	GO:0005887	1/92	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZKN35	GO:0052689	2/163	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG8S7N4M	GO:0046872	2/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8S7N4M	GO:0003676	2/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KWN8W	GO:0031409	4/7	pigment binding	molecular_function	"Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah]
EOG8KWN8W	GO:0005576	2/7	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8KWN8W	GO:0036094	1/7	small molecule binding	molecular_function	"Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]
EOG8NW203	GO:0004871	36/117	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8NW203	GO:0004713	36/117	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8NW203	GO:0005925	36/117	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8NW203	GO:0007172	36/117	signal complex assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell." [GOC:bf, GOC:signaling, PMID:9646862]
EOG8NW203	GO:0005524	24/117	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8NW203	GO:0005856	24/117	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8NW203	GO:0004715	3/117	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8NW203	GO:0004672	2/117	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8NW203	GO:0045886	1/117	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8NW203	GO:0007016	1/117	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG8NW203	GO:0008360	1/117	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8NW203	GO:0006468	1/117	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8NW203	GO:0061177	1/117	type Is terminal bouton	cellular_component	"Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons." [GOC:dph, GOC:mc]
EOG8NW203	GO:0061176	1/117	type Ib terminal bouton	cellular_component	"Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons." [GOC:dph, GOC:mc]
EOG8NW203	GO:0018108	1/117	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG8FTZG4	GO:0003677	23/88	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FTZG4	GO:0003682	21/88	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8FTZG4	GO:0005634	1/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8KWN8H	GO:0030414	2/5	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8XH2J0	GO:0046872	2/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XH2J0	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8TMTFX	GO:0046872	20/75	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TMTFX	GO:0005524	12/75	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8TMTFX	GO:0017111	12/75	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8TMTFX	GO:0004386	2/75	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8BS00N	GO:0016021	46/215	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BS00N	GO:0015377	45/215	cation:chloride symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [TC:2.A.30.-.-]
EOG8BS00N	GO:0016020	21/215	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8BS00N	GO:0055085	20/215	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8BS00N	GO:0015171	2/215	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8BS00N	GO:0005215	2/215	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8BS00N	GO:0003333	2/215	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG8BS00N	GO:0006811	2/215	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8BS00N	GO:1902476	1/215	chloride transmembrane transport	biological_process	"The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw]
EOG8BS00N	GO:0008511	1/215	sodium:potassium:chloride symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)." [TC:2.A.30.1.1]
EOG8BS00N	GO:0006821	1/215	chloride transport	biological_process	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8BS00N	GO:0005886	1/215	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8BS00N	GO:0035826	1/215	rubidium ion transport	biological_process	"The directed movement of rubidium ions (Rb+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:49847, GOC:yaf]
EOG8BS00N	GO:0006813	1/215	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG87H841	GO:0007165	8/19	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG87H841	GO:0004114	8/19	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular_function	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]
EOG87H841	GO:0046872	6/19	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8F7R4F	GO:0016301	1/5	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8NW20C	GO:0016020	20/72	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NW20C	GO:0005524	20/72	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8NW20C	GO:0016887	18/72	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8NW20C	GO:0015412	2/72	molybdate transmembrane-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)." [EC:3.6.3.29]
EOG8NW20C	GO:0042752	1/72	regulation of circadian rhythm	biological_process	"Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]
EOG89W4WC	GO:0005737	24/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG89W4WC	GO:0061024	1/86	membrane organization	biological_process	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]
EOG89W4WC	GO:0016020	1/86	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG89W4WC	GO:0007296	1/86	vitellogenesis	biological_process	"The production of yolk. Yolk is a mixture of materials used for embryonic nutrition." [GOC:dph, ISBN:0879694238]
EOG89W4WC	GO:0030100	1/86	regulation of endocytosis	biological_process	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]
EOG80KBF2	GO:0003682	1/7	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8DBWW1	GO:0016021	4/11	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DBWW1	GO:0016740	4/11	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8DBWW1	GO:0006633	4/11	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8MSGCH	GO:0016624	22/89	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]
EOG8MSGCH	GO:0003863	4/89	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	molecular_function	"Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2." [EC:1.2.4.4]
EOG8B013X	GO:0007186	5/18	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8B013X	GO:0003924	5/18	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8B013X	GO:0004871	5/18	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8B013X	GO:0005525	4/18	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8B013X	GO:0007264	2/18	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8B013X	GO:0019001	1/18	guanyl nucleotide binding	molecular_function	"Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]
EOG805VDW	GO:0016020	82/211	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG805VDW	GO:0005215	82/211	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG805VDW	GO:0031427	1/211	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG8PG8HT	GO:0006412	20/68	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8PG8HT	GO:0003735	20/68	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8PG8HT	GO:0005840	20/68	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8PG8HR	GO:0003964	4/50	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8PG8HR	GO:0003723	3/50	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8PG8HR	GO:0004519	1/50	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8PG8HR	GO:0008270	1/50	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84BDMK	GO:0005213	7/33	structural constituent of chorion	molecular_function	"The action of a molecule that contributes to the structural integrity of a chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu]
EOG84BDMK	GO:0042600	7/33	chorion	cellular_component	"A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
EOG84BDMK	GO:0007304	7/33	chorion-containing eggshell formation	biological_process	"The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG84BDMK	GO:0007275	7/33	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8JWXW2	GO:0016021	3/38	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JWXW2	GO:0006811	3/38	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84QWDQ	GO:0016887	23/87	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG84QWDQ	GO:0005524	23/87	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG84QWDX	GO:0035317	1/95	imaginal disc-derived wing hair organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853]
EOG84QWDX	GO:0005938	1/95	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG84QWDX	GO:0035017	1/95	cuticle pattern formation	biological_process	"The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf]
EOG84QWDX	GO:0048800	1/95	antennal morphogenesis	biological_process	"The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid]
EOG84QWDX	GO:0009913	1/95	epidermal cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]
EOG8NZX8B	GO:0016021	3/176	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NZX8B	GO:0006506	2/176	GPI anchor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
EOG8NZX8B	GO:0000139	2/176	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8NZX8B	GO:0015031	2/176	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8NZX8B	GO:0005789	2/176	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8NZX8B	GO:0008565	2/176	protein transporter activity	molecular_function	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
EOG88WFKR	GO:0004252	1/3	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8NZX8F	GO:0003676	3/18	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NZX8F	GO:0046872	2/18	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NZX8F	GO:0005634	1/18	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NZX8F	GO:0008270	1/18	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NGK4D	GO:0005328	2/21	neurotransmitter:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
EOG8NGK4D	GO:0016021	2/21	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WQ3JX	GO:0016539	1/38	intein-mediated protein splicing	biological_process	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]
EOG8XWJG4	GO:0005213	2/4	structural constituent of chorion	molecular_function	"The action of a molecule that contributes to the structural integrity of a chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu]
EOG8XWJG4	GO:0042600	2/4	chorion	cellular_component	"A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
EOG8XWJG4	GO:0007275	2/4	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8XWJG4	GO:0007304	2/4	chorion-containing eggshell formation	biological_process	"The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8VT8B5	GO:0030424	3/282	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8VT8B5	GO:0007411	3/282	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8VT8B5	GO:0008406	3/282	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG8VT8B5	GO:0022409	2/282	positive regulation of cell-cell adhesion	biological_process	"Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
EOG8VT8B5	GO:0016319	2/282	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8VT8B5	GO:2000274	2/282	regulation of epithelial cell migration, open tracheal system	biological_process	"Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system." [GOC:obol]
EOG8VT8B5	GO:0003151	2/282	outflow tract morphogenesis	biological_process	"The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145]
EOG8VT8B5	GO:0048036	2/282	central complex development	biological_process	"The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252]
EOG8VT8B5	GO:0035050	2/282	embryonic heart tube development	biological_process	"The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
EOG8VT8B5	GO:0004872	2/282	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8VT8B5	GO:0008038	2/282	neuron recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators]
EOG8VT8B5	GO:0007419	2/282	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8VT8B5	GO:0007432	2/282	salivary gland boundary specification	biological_process	"Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957]
EOG8VT8B5	GO:0005886	1/282	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8VT8B5	GO:0031987	1/282	locomotion involved in locomotory behavior	biological_process	"Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
EOG8VT8B5	GO:0048854	1/282	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG8VT8B5	GO:0009649	1/282	entrainment of circadian clock	biological_process	"The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid]
EOG8VT8B5	GO:0001764	1/282	neuron migration	biological_process	"The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]
EOG8VT8B5	GO:0007427	1/282	epithelial cell migration, open tracheal system	biological_process	"The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8VT8B5	GO:0043025	1/282	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8VT8B5	GO:0005887	1/282	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VT8B5	GO:0005515	1/282	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VT8B5	GO:0035385	1/282	Roundabout signaling pathway	biological_process	"A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling]
EOG8VT8B5	GO:0044295	1/282	axonal growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954]
EOG8VT8B5	GO:0016199	1/282	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG8VT8B5	GO:0030425	1/282	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8VT8B5	GO:0001964	1/282	startle response	biological_process	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
EOG8VT8B5	GO:0046716	1/282	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG8VT8B5	GO:0042685	1/282	cardioblast cell fate specification	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG8VT8B5	GO:0071666	1/282	Slit-Robo signaling complex	cellular_component	"A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate." [GOC:sart, PMID:17062560, PMID:18359766]
EOG8VT8B5	GO:0072499	1/282	photoreceptor cell axon guidance	biological_process	"The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
EOG8VT8B5	GO:0042803	1/282	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8VT8B5	GO:0031982	1/282	vesicle	cellular_component	"Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz]
EOG8VT8B5	GO:0007426	1/282	tracheal outgrowth, open tracheal system	biological_process	"The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8VT8B5	GO:0008201	1/282	heparin binding	molecular_function	"Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]
EOG8VT8B5	GO:0048813	1/282	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8VT8B5	GO:0008039	1/282	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8VT8B5	GO:0043234	1/282	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8VT8B5	GO:0070983	1/282	dendrite guidance	biological_process	"The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
EOG8VT8B5	GO:0050773	1/282	regulation of dendrite development	biological_process	"Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai]
EOG8VT8B5	GO:0008045	1/282	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8D81MQ	GO:0004252	1/49	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8D81MW	GO:0008080	22/171	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG8R52KD	GO:0003677	2/4	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8JWXWP	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JWXWP	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8D2968	GO:0003677	56/1616	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8D2968	GO:0006313	36/1616	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG8D2968	GO:0015074	36/1616	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8D2968	GO:0004803	36/1616	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG8D2968	GO:0006355	9/1616	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8D2968	GO:0008270	4/1616	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D2968	GO:0007275	3/1616	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8D2968	GO:0005634	3/1616	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D2968	GO:0006351	3/1616	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8HB11C	GO:0004356	2/4	glutamate-ammonia ligase activity	molecular_function	"Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.2, RHEA:16172]
EOG8HB11C	GO:0006807	1/4	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG8HB11C	GO:0006542	1/4	glutamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
EOG88972H	GO:0016491	5/9	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8MWBPS	GO:0005634	3/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8MWBPS	GO:0000786	3/5	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8MWBPS	GO:0003677	3/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8MWBPS	GO:0006334	3/5	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG81VNK1	GO:0001539	1/52	cilium or flagellum-dependent cell motility	biological_process	"Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc]
EOG81VNK1	GO:0003774	1/52	motor activity	molecular_function	"Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
EOG81VNK1	GO:0009288	1/52	bacterial-type flagellum	cellular_component	"A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:jh2, GOC:krc, GOC:mtg_sensu, http:en.wikipedia.org/wiki/Flagellum#Bacterial, PMID:7787060]
EOG88972Z	GO:0003682	1/27	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8323CQ	GO:0016021	4/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8323CQ	GO:0007155	4/9	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8323CZ	GO:0003677	1/119	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8323CZ	GO:0003676	1/119	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8323CZ	GO:0046872	1/119	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89GP01	GO:0003676	1/3	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89GP01	GO:0046872	1/3	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84XMZS	GO:0046872	1/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8P2SJ5	GO:0004867	2/4	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG8323C4	GO:0007076	2/7	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG82VBWZ	GO:0003993	33/135	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG82VBWZ	GO:0052826	1/135	inositol hexakisphosphate 2-phosphatase activity	molecular_function	"Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.62]
EOG854CDC	GO:0005524	20/53	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG854CDC	GO:0004674	18/53	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG854CDC	GO:0004683	2/53	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG854CDC	GO:0006468	1/53	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG854CDC	GO:0007155	1/53	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG854CDC	GO:0003700	1/53	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG854CDC	GO:0043565	1/53	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG854CDC	GO:0008360	1/53	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG82VBWQ	GO:0007229	2/6	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG82VBWN	GO:0005622	9/52	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG82VBWN	GO:0007165	9/52	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG82VBWN	GO:0005096	6/52	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG82VBWN	GO:0005089	1/52	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG86MF19	GO:0000387	24/85	spliceosomal snRNP assembly	biological_process	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG86MF19	GO:0005829	1/85	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG86MF19	GO:0005634	1/85	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86MF19	GO:0005856	1/85	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG80307N	GO:0016021	4/14	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8T1M1F	GO:0005795	98/220	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG8T1M1F	GO:0008378	92/220	galactosyltransferase activity	molecular_function	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]
EOG8T1M1F	GO:0050512	6/220	lactosylceramide 4-alpha-galactosyltransferase activity	molecular_function	"Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.228, MetaCyc:2.4.1.228-RXN]
EOG8T1M1F	GO:0009247	1/220	glycolipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators]
EOG8T1M1F	GO:0006688	1/220	glycosphingolipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators]
EOG8T1M1F	GO:0035248	1/220	alpha-1,4-N-acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage." [PMID:15130086]
EOG8T1M1F	GO:0016787	1/220	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8T1M1F	GO:0008376	1/220	acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]
EOG8T1M1F	GO:0045747	1/220	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8T1M1F	GO:0043066	1/220	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8T1M1N	GO:0008270	4/13	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8T1M1N	GO:0005634	4/13	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8T1M1N	GO:0016853	1/13	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8HB113	GO:0046331	1/67	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8RR8XP	GO:0016021	34/109	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RR8XP	GO:0004983	30/109	neuropeptide Y receptor activity	molecular_function	"Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
EOG8RR8XP	GO:0004930	4/109	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8RR8XP	GO:0050254	3/109	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8RR8XP	GO:0070374	1/109	positive regulation of ERK1 and ERK2 cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]
EOG8RR8XP	GO:2000253	1/109	positive regulation of feeding behavior	biological_process	"Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol]
EOG8RR8XP	GO:0036400	1/109	short neuropeptide F receptor activity	molecular_function	"Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide." [GOC:ha, PMID:16330127, PMID:21440021]
EOG8RR8XP	GO:0040018	1/109	positive regulation of multicellular organism growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8RR8XP	GO:0005887	1/109	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RR8XP	GO:0007218	1/109	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8RR8XP	GO:0007186	1/109	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8RR8XP	GO:0008188	1/109	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG889727	GO:0022857	1/5	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG889727	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80307P	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80307P	GO:0005328	1/5	neurotransmitter:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
EOG8MD0F8	GO:0016773	22/80	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8MD0F8	GO:0005975	22/80	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8MD0F8	GO:0004435	1/80	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8MD0F8	GO:0035556	1/80	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8MD0F8	GO:0006629	1/80	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8MD0F3	GO:0004185	5/8	serine-type carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8NCPSK	GO:0030554	22/105	adenyl nucleotide binding	molecular_function	"Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732]
EOG89S8PW	GO:0005634	2/31	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG89S8PW	GO:0006355	2/31	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG89S8PT	GO:0005549	1/5	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8GXJ3M	GO:0004930	1/6	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8GXJ3M	GO:0004984	1/6	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8GXJ3M	GO:0016021	1/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GXJ3M	GO:0005549	1/6	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8Z91B1	GO:0022891	2/5	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8Z91B1	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z91B1	GO:0008643	1/5	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8QC3N6	GO:0008080	28/96	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG8QC3N6	GO:0004145	1/96	diamine N-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." [EC:2.3.1.57]
EOG8PVRG2	GO:0004222	2/6	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG83BQ4B	GO:0005615	38/85	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG83BQ4B	GO:0008233	9/85	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG83BQ4B	GO:0010951	2/85	negative regulation of endopeptidase activity	biological_process	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG83BQ4B	GO:0004867	2/85	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG83BQ4B	GO:0030162	2/85	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG83BQ4B	GO:0032504	2/85	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG83BQ4B	GO:0035009	1/85	negative regulation of melanization defense response	biological_process	"Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection." [GOC:bf, PMID:12408809]
EOG83BQ4B	GO:0005576	1/85	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG83BQ4B	GO:0045861	1/85	negative regulation of proteolysis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
EOG866Z27	GO:0005549	1/5	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG866Z27	GO:0016020	1/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG866Z27	GO:0004984	1/5	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8Z91BX	GO:0016491	2/4	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8BVV83	GO:0009166	125/386	nucleotide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]
EOG8BVV83	GO:0046872	81/386	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8BVV83	GO:0000166	80/386	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8BVV83	GO:0016788	75/386	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG8BVV83	GO:0016787	38/386	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8BVV83	GO:0008253	12/386	5'-nucleotidase activity	molecular_function	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]
EOG8BVV83	GO:0016311	2/386	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG8BVV83	GO:0017110	1/386	nucleoside-diphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate." [EC:3.6.1.6]
EOG8BVV83	GO:0005524	1/386	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8BVV83	GO:0017111	1/386	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8BVV83	GO:0005576	1/386	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8BVV83	GO:0045134	1/386	uridine-diphosphatase activity	molecular_function	"Catalysis of the reaction: UDP + H2O = UMP + phosphate." [EC:3.6.1.6]
EOG8GF5VB	GO:0000226	28/99	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8GF5VB	GO:0005874	28/99	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8GF5VB	GO:0007017	1/99	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8GF5VB	GO:0008017	1/99	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8GF5VB	GO:0005875	1/99	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8KD936	GO:0016021	77/225	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KD936	GO:0005918	3/225	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG8KD936	GO:0019991	3/225	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG8KD936	GO:0060857	3/225	establishment of glial blood-brain barrier	biological_process	"Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
EOG8KD936	GO:0035151	2/225	regulation of tube size, open tracheal system	biological_process	"Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]
EOG8KD936	GO:0007424	2/225	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8KD936	GO:0005919	1/225	pleated septate junction	cellular_component	"A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298]
EOG8KD936	GO:0005198	1/225	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8KD936	GO:0005923	1/225	bicellular tight junction	cellular_component	"An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181]
EOG8KD936	GO:0005886	1/225	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8KD936	GO:0061343	1/225	cell adhesion involved in heart morphogenesis	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
EOG8KD936	GO:0005515	1/225	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KD936	GO:0035159	1/225	regulation of tube length, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
EOG8KD936	GO:0003015	1/225	heart process	biological_process	"A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]
EOG8KD936	GO:0007391	1/225	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8KD936	GO:0035002	1/225	liquid clearance, open tracheal system	biological_process	"The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352]
EOG8PVRGC	GO:0005549	63/151	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8PVRGC	GO:0005576	2/151	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8PVRGC	GO:0007606	2/151	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8PVRGC	GO:0005550	2/151	pheromone binding	molecular_function	"Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai]
EOG8PVRGC	GO:0006810	1/151	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG866Z2R	GO:0000166	13/73	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG866Z2R	GO:0003676	12/73	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG866Z2R	GO:0022008	1/73	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG866Z2R	GO:0003729	1/73	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG808QP5	GO:0005215	34/99	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG808QP5	GO:0055085	34/99	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG808QP5	GO:0016020	31/99	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG808QP5	GO:0016021	3/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG808QP5	GO:0005634	1/99	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG808QP5	GO:0008270	1/99	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG808QP5	GO:0003676	1/99	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Z91BN	GO:0006030	32/94	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8Z91BN	GO:0005576	32/94	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Z91BN	GO:0008061	32/94	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8GXJ33	GO:0005215	2/6	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8GXJ33	GO:0005622	2/6	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8MD0FW	GO:0003676	3/12	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84J4XZ	GO:0015991	77/236	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG84J4XZ	GO:0015078	74/236	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG84J4XZ	GO:0000220	70/236	vacuolar proton-transporting V-type ATPase, V0 domain	cellular_component	"The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG84J4XZ	GO:0033179	7/236	proton-transporting V-type ATPase, V0 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG84J4XZ	GO:0008553	3/236	hydrogen-exporting ATPase activity, phosphorylative mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle." [EC:3.6.3.6]
EOG84J4XZ	GO:0016787	3/236	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG84J4XZ	GO:0046961	2/236	proton-transporting ATPase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]
EOG84J4XZ	GO:0007165	1/236	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG84J4XZ	GO:0005516	1/236	calmodulin binding	molecular_function	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
EOG84J4XZ	GO:0045202	1/236	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG84J4XZ	GO:0005886	1/236	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG84J4XZ	GO:0033181	1/236	plasma membrane proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
EOG84J4XZ	GO:0051452	1/236	intracellular pH reduction	biological_process	"Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai]
EOG84J4XZ	GO:0009416	1/236	response to light stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
EOG84J4XZ	GO:0008021	1/236	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG84J4XZ	GO:0005769	1/236	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG84J4XZ	GO:0009881	1/236	photoreceptor activity	molecular_function	"The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators]
EOG8MD0FH	GO:0003676	1/47	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MD0FH	GO:0008270	1/47	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FFGHB	GO:0006950	26/583	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8FFGHB	GO:0005212	9/583	structural constituent of eye lens	molecular_function	"The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah]
EOG8FFGHB	GO:0008340	3/583	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8FFGHB	GO:0005875	3/583	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8FFGHB	GO:0010998	2/583	regulation of translational initiation by eIF2 alpha phosphorylation	biological_process	"Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha." [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb]
EOG8FFGHB	GO:0009631	2/583	cold acclimation	biological_process	"Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr]
EOG8FFGHB	GO:0005515	2/583	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FFGHB	GO:0007275	1/583	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8FFGHB	GO:0017022	1/583	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8FFGHB	GO:0042595	1/583	behavioral response to starvation	biological_process	"Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators]
EOG8FFGHB	GO:0009408	1/583	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8FFGHB	GO:0007476	1/583	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8FFGHB	GO:0010506	1/583	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8FFGHB	GO:0003779	1/583	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8FFGHB	GO:0006497	1/583	protein lipidation	biological_process	"The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]
EOG8FFGHB	GO:0001666	1/583	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG8FFGHB	GO:0006979	1/583	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8FFGHB	GO:0031427	1/583	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG8FFGHB	GO:0050832	1/583	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8FFGHB	GO:0042742	1/583	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8MD0FC	GO:0003676	1/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FFGHF	GO:0044262	2/4	cellular carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
EOG8FFGHF	GO:0016616	2/4	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8XD67H	GO:0016874	2/16	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8NW21R	GO:0016020	1/3	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NW21R	GO:0005509	1/3	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8WWV0F	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WWV0F	GO:0022857	1/5	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8FTZFP	GO:0005549	1/4	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8FTZFP	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FTZFP	GO:0004984	1/4	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8FTZFP	GO:0004930	1/4	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8TMTGZ	GO:0004252	1/4	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8BS01J	GO:0003676	32/94	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BS01J	GO:0004527	8/94	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8BS01J	GO:0008853	1/94	exodeoxyribonuclease III activity	molecular_function	"Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.2]
EOG8BS01J	GO:0006950	1/94	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8PRW6S	GO:0046872	2/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8X9B0H	GO:0004930	20/144	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8X9B0H	GO:0016021	19/144	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X9B0H	GO:0006950	2/144	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8X9B0H	GO:0005524	1/144	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X9B0H	GO:0004674	1/144	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8BS01B	GO:0005215	139/496	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8BS01B	GO:0005622	138/496	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8BS01B	GO:0016787	14/496	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8BS01B	GO:0005811	1/496	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG834ZNQ	GO:0005089	4/37	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG89W4VG	GO:0008270	3/32	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG89W4VG	GO:0003676	3/32	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89W4VG	GO:0005634	3/32	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG89W4VG	GO:0046872	1/32	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG803085	GO:0003676	2/11	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG803085	GO:0046872	2/11	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG803085	GO:0008270	2/11	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8J13R1	GO:0005549	3/9	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8J13R1	GO:0004984	3/9	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8J13R1	GO:0016020	2/9	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8J13R1	GO:0004930	1/9	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8J13R1	GO:0016021	1/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J13R1	GO:0005886	1/9	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8P8HXX	GO:0003676	2/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8P8HXX	GO:0046872	2/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8B0140	GO:0005506	10/60	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8B0140	GO:0006633	10/60	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8B0140	GO:0016491	10/60	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8B0140	GO:0016021	9/60	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8B0147	GO:0004252	2/5	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8B0146	GO:0005524	53/172	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8B0146	GO:0004674	48/172	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8B0146	GO:0004672	4/172	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8B0146	GO:0004683	3/172	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG8B0146	GO:0006468	2/172	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8B0146	GO:0000780	1/172	condensed nuclear chromosome, centromeric region	cellular_component	"The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
EOG8B0146	GO:0005813	1/172	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8B0146	GO:0007076	1/172	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8B0146	GO:0000281	1/172	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8B0146	GO:0000070	1/172	mitotic sister chromatid segregation	biological_process	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
EOG8B0146	GO:0051233	1/172	spindle midzone	cellular_component	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
EOG8B0146	GO:0006325	1/172	chromatin organization	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
EOG8B0146	GO:0008608	1/172	attachment of spindle microtubules to kinetochore	biological_process	"The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137]
EOG8B0146	GO:0051298	1/172	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8B0146	GO:0051297	1/172	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8B0146	GO:0051299	1/172	centrosome separation	biological_process	"The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai]
EOG8B0146	GO:0000775	1/172	chromosome, centromeric region	cellular_component	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
EOG8B0146	GO:0016572	1/172	histone phosphorylation	biological_process	"The modification of histones by addition of phosphate groups." [GOC:ai]
EOG8B0146	GO:0007100	1/172	mitotic centrosome separation	biological_process	"Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194]
EOG8B0146	GO:0007052	1/172	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8B0146	GO:0000776	1/172	kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG8B0146	GO:0007126	1/172	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8B0146	GO:0005737	1/172	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8B0146	GO:0030496	1/172	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG8B0146	GO:0007279	1/172	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8B0146	GO:0007098	1/172	centrosome cycle	biological_process	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]
EOG8B0146	GO:0005819	1/172	spindle	cellular_component	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
EOG8B0146	GO:0032133	1/172	chromosome passenger complex	cellular_component	"A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910]
EOG8B0146	GO:0008105	1/172	asymmetric protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma]
EOG8B0146	GO:0022008	1/172	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8B0146	GO:0050767	1/172	regulation of neurogenesis	biological_process	"Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]
EOG8B0146	GO:0046872	1/172	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8B0146	GO:0051294	1/172	establishment of spindle orientation	biological_process	"Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai]
EOG8B0146	GO:0045167	1/172	asymmetric protein localization involved in cell fate determination	biological_process	"Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai]
EOG8B0146	GO:0007017	1/172	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8NW211	GO:0016021	1/40	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NW212	GO:0046872	1/3	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8MSGCC	GO:0004252	1/103	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8MSGCC	GO:0005515	1/103	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FTZF0	GO:0005524	2/8	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8FTZF0	GO:0016887	2/8	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8DFS5H	GO:0016021	1/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DFS5H	GO:0004930	1/9	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8KSS0Q	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KSS0Q	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GJ23Q	GO:0004252	4/26	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8WWV02	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WWV02	GO:0022857	1/5	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8WWV02	GO:0022891	1/5	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8WWV02	GO:0008643	1/5	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8KSS0W	GO:0030246	2/5	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8KSS0K	GO:0003743	1/5	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8PRW62	GO:0046872	1/3	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XD676	GO:0005524	1/3	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8XD676	GO:0016887	1/3	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG87H855	GO:0000079	1/4	regulation of cyclin-dependent protein serine/threonine kinase activity	biological_process	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]
EOG8FTZF6	GO:0043565	4/77	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8FTZF6	GO:0003700	4/77	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG83FKD0	GO:0005737	3/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83FKD0	GO:0006886	2/94	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG83FKD0	GO:0090382	1/94	phagosome maturation	biological_process	"A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome." [GOC:kmv, GOC:tb]
EOG83FKD0	GO:0090385	1/94	phagosome-lysosome fusion	biological_process	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]
EOG83FKD0	GO:0006955	1/94	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG83FKD0	GO:0016197	1/94	endosomal transport	biological_process	"The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]
EOG83FKD0	GO:0005515	1/94	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG83FKD0	GO:0035542	1/94	regulation of SNARE complex assembly	biological_process	"Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
EOG83FKD0	GO:0030897	1/94	HOPS complex	cellular_component	"A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161]
EOG83FKD0	GO:0033263	1/94	CORVET complex	cellular_component	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]
EOG880MB9	GO:0008270	3/7	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG880MB9	GO:0005634	1/7	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG880MB9	GO:0006281	1/7	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG880MB9	GO:0004842	1/7	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG880MB9	GO:0003677	1/7	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86X1PH	GO:0008270	23/100	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG86X1PH	GO:0032312	23/100	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG86X1PH	GO:0008060	23/100	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG86X1PH	GO:0005737	6/100	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86X1PH	GO:0043547	1/100	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG86X1PH	GO:0016787	1/100	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG86X1PH	GO:0000902	1/100	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG86X1PH	GO:0016906	1/100	sterol 3-beta-glucosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol." [EC:2.4.1.173]
EOG86X1PH	GO:0006909	1/100	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG86X1PH	GO:0016021	1/100	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8MPM65	GO:0005515	1/78	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8MPM65	GO:0055114	1/78	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8MPM65	GO:0045454	1/78	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8MPM65	GO:0015036	1/78	disulfide oxidoreductase activity	molecular_function	"Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]
EOG87Q0N5	GO:0008270	1/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84TRRR	GO:0003964	1/4	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG84TRRR	GO:0003723	1/4	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG82RGP9	GO:0005634	16/49	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82RGP9	GO:0003707	16/49	steroid hormone receptor activity	molecular_function	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
EOG82RGP9	GO:0003700	15/49	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG82RGP9	GO:0006351	15/49	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG82RGP9	GO:0008270	15/49	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG82RGP9	GO:0043565	15/49	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG82RGP9	GO:0004879	1/49	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	molecular_function	"Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH]
EOG82RGP9	GO:0030522	1/49	intracellular receptor signaling pathway	biological_process	"Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah]
EOG8MPM6C	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG87Q0NB	GO:0016020	5/13	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG87Q0NB	GO:0007264	5/13	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG87Q0NB	GO:0005525	5/13	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG87Q0NB	GO:0005622	5/13	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG87Q0NB	GO:0004767	1/13	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8MPM6P	GO:0003700	2/6	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8MPM6P	GO:0043565	2/6	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8MPM6P	GO:0005634	2/6	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87Q0P0	GO:0006355	3/24	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG87Q0P0	GO:0005634	3/24	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8DBWTN	GO:0005216	8/47	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8DBWTN	GO:0016021	8/47	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DBWTN	GO:0005509	1/47	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8BVVBB	GO:0005509	26/84	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8BVVBB	GO:0032504	1/84	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8BVVBB	GO:0005615	1/84	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8DBWTS	GO:0006464	7/44	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG8DBWTS	GO:0006364	1/44	rRNA processing	biological_process	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
EOG8DBWTS	GO:0032040	1/44	small-subunit processome	cellular_component	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]
EOG80CKXV	GO:0003676	3/8	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80CKXV	GO:0005634	2/8	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80CKXV	GO:0008270	2/8	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80CKXV	GO:0046872	1/8	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80CKXV	GO:0003700	1/8	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8TXF7J	GO:0005730	1/119	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8TXF7J	GO:0022008	1/119	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84QWG9	GO:0016117	1/11	carotenoid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators]
EOG84QWG9	GO:0055114	1/11	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8FR368	GO:0016747	3/17	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG80CKXG	GO:0043565	44/146	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG80CKXG	GO:0005634	44/146	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80CKXG	GO:0003700	44/146	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG80CKXG	GO:0008270	44/146	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80CKXG	GO:0016740	3/146	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG80CKXG	GO:0048813	1/146	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG80CKXG	GO:0006909	1/146	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG82FVZH	GO:0005576	1/83	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG82FVZH	GO:0031637	1/83	regulation of neuronal synaptic plasticity in response to neurotrophin	biological_process	"The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah, PMID:8703078]
EOG82FVZH	GO:0007411	1/83	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG82FVZH	GO:0008045	1/83	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG82FVZH	GO:0010941	1/83	regulation of cell death	biological_process	"Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]
EOG82FVZH	GO:0005121	1/83	Toll binding	molecular_function	"Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb]
EOG82FVZH	GO:0008083	1/83	growth factor activity	molecular_function	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]
EOG82FVZH	GO:0007399	1/83	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG82FVZH	GO:0008063	1/83	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG82FVZH	GO:0021556	1/83	central nervous system formation	biological_process	"The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089]
EOG84BDJJ	GO:0004252	1/5	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG84BDJJ	GO:0003824	1/5	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8F20GW	GO:0006909	1/100	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8F20GW	GO:0045771	1/100	negative regulation of autophagosome size	biological_process	"Any process that reduces autophagosome size." [GOC:autophagy, GOC:go_curators]
EOG8F20GW	GO:0005509	1/100	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8FR36M	GO:0008270	1/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FR36M	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FR36M	GO:0005634	1/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80CKX9	GO:0050660	12/64	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG80CKX9	GO:0008812	11/64	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG80CKX9	GO:0006066	11/64	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG80CKX9	GO:0004344	1/64	glucose dehydrogenase activity	molecular_function	"Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10]
EOG80CKX9	GO:0016614	1/64	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8FR36G	GO:0016021	86/188	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FR36G	GO:0055085	85/188	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8FR36G	GO:0005215	29/188	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8FR36G	GO:0031427	1/188	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG8FR36G	GO:0052591	1/188	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	molecular_function	"Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." [MetaCyc:GLYC3PDEHYDROG-RXN]
EOG8FR36G	GO:0006072	1/188	glycerol-3-phosphate metabolic process	biological_process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]
EOG8FR36G	GO:0022857	1/188	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8FR36G	GO:0009331	1/188	glycerol-3-phosphate dehydrogenase complex	cellular_component	"An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3]
EOG8935XR	GO:0003774	30/113	motor activity	molecular_function	"Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
EOG8935XR	GO:0016459	29/113	myosin complex	cellular_component	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
EOG8935XR	GO:0032440	1/113	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8935XR	GO:0030239	1/113	myofibril assembly	biological_process	"Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]
EOG8935XR	GO:0032982	1/113	myosin filament	cellular_component	"A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah]
EOG8935XR	GO:0008152	1/113	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8935XR	GO:0007498	1/113	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8935XR	GO:0030016	1/113	myofibril	cellular_component	"The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194]
EOG8Q2GWQ	GO:0016772	2/5	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8FR36D	GO:0042302	96/271	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8FR36D	GO:0040003	4/271	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8FR36D	GO:0008010	4/271	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8FR36D	GO:0031012	4/271	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8FR36D	GO:0004252	3/271	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8FR36D	GO:0008270	1/271	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84QWGG	GO:0003677	13/47	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84QWGG	GO:0003676	4/47	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84QWGG	GO:0046872	2/47	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Q2GWK	GO:0016021	1/120	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FR36V	GO:0008270	1/8	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q87CQ	GO:0006629	1/4	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8H1D9Q	GO:0003676	2/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8H1D9Q	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8H1D9Q	GO:0008270	1/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8H1D9Q	GO:0005634	1/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8QFZV3	GO:0005975	201/525	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8QFZV3	GO:0043169	199/525	cation binding	molecular_function	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]
EOG8QFZV3	GO:0003824	188/525	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8QFZV3	GO:0032450	12/525	maltose alpha-glucosidase activity	molecular_function	"Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141]
EOG8QFZV3	GO:0016740	1/525	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8QFZV3	GO:0003677	1/525	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8QFZV2	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QFZV2	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG866Z1H	GO:0005868	29/105	cytoplasmic dynein complex	cellular_component	"Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:mah, PMID:12600311]
EOG866Z1H	GO:0007018	29/105	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG866Z1H	GO:0003777	29/105	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG866Z1H	GO:0007067	1/105	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG866Z1H	GO:0000226	1/105	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG866Z1H	GO:0051028	1/105	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG866Z1H	GO:0007409	1/105	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG866Z1H	GO:0048477	1/105	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG866Z1H	GO:0030286	1/105	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG866Z1H	GO:0042623	1/105	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG866Z1H	GO:0048814	1/105	regulation of dendrite morphogenesis	biological_process	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG866Z1H	GO:0006200	1/105	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG866Z1H	GO:0048813	1/105	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG866Z1H	GO:0008088	1/105	axon cargo transport	biological_process	"The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194]
EOG866Z1H	GO:0007052	1/105	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8H1D9H	GO:0004749	2/4	ribose phosphate diphosphokinase activity	molecular_function	"Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+)." [EC:2.7.6.1, RHEA:15612]
EOG8H1D9H	GO:0009156	2/4	ribonucleoside monophosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
EOG8H1D9H	GO:0009165	2/4	nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]
EOG8H1D9H	GO:0000287	2/4	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8TB6RB	GO:0004713	2/5	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8TB6RB	GO:0005524	2/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8MD0GX	GO:0005576	1/4	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8NKF91	GO:0004871	39/124	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8NKF91	GO:0006351	34/124	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8NKF91	GO:0005634	34/124	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NKF91	GO:0003677	33/124	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NKF91	GO:0006355	20/124	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8NKF91	GO:0003700	16/124	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NKF91	GO:0005667	16/124	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8NKF91	GO:0005737	16/124	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8NKF91	GO:0046982	2/124	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8NKF91	GO:0045944	2/124	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8NKF91	GO:0008134	2/124	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8NKF91	GO:0043069	2/124	negative regulation of programmed cell death	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
EOG8NKF91	GO:0042803	1/124	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8NKF91	GO:0005500	1/124	juvenile hormone binding	molecular_function	"Interacting selectively and non-covalently with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732]
EOG8NKF91	GO:0050793	1/124	regulation of developmental process	biological_process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]
EOG84N160	GO:0016772	2/5	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8HB126	GO:0004252	1/4	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8HB125	GO:0003676	4/12	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HB125	GO:0000166	4/12	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8NKF97	GO:0008324	44/191	cation transmembrane transporter activity	molecular_function	"Enables the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
EOG8T4G85	GO:0005737	12/117	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8T4G85	GO:0005634	11/117	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8T4G85	GO:0048489	1/117	synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr]
EOG8T4G85	GO:0005524	1/117	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8T4G85	GO:0000132	1/117	establishment of mitotic spindle orientation	biological_process	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
EOG8T4G85	GO:0016020	1/117	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8T4G85	GO:0042626	1/117	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8T4G85	GO:0048812	1/117	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8T4G85	GO:0008088	1/117	axon cargo transport	biological_process	"The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194]
EOG889750	GO:0055085	1/4	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG889750	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8T4G86	GO:0005509	23/92	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8T4G86	GO:0008061	2/92	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8T4G86	GO:0005576	2/92	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8T4G86	GO:0006030	2/92	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8W10TV	GO:0016021	59/189	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W10TV	GO:0004889	55/189	acetylcholine-activated cation-selective channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]
EOG8W10TV	GO:0030054	55/189	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8W10TV	GO:0045211	55/189	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8W10TV	GO:0006812	3/189	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8W10TV	GO:0006811	3/189	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8W10TV	GO:0005892	3/189	acetylcholine-gated channel complex	cellular_component	"A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding." [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462]
EOG8W10TV	GO:0005230	2/189	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8W10TV	GO:0007271	2/189	synaptic transmission, cholinergic	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse using the neurotransmitter acetylcholine." [GOC:kmv, GOC:pr, Wikipedia:Cholinergic]
EOG8W10TV	GO:0007268	1/189	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8W10TV	GO:0043197	1/189	dendritic spine	cellular_component	"Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln]
EOG8W10TV	GO:0060079	1/189	excitatory postsynaptic potential	biological_process	"A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dph, GOC:ef]
EOG8W10TV	GO:0007632	1/189	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG8W10TV	GO:0030425	1/189	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8W10TV	GO:0042166	1/189	acetylcholine binding	molecular_function	"Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
EOG8W10TV	GO:0014069	1/189	postsynaptic density	cellular_component	"The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell." [GOC:BHF, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]
EOG8W10TV	GO:0046716	1/189	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG8W10TV	GO:0007630	1/189	jump response	biological_process	"The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jid, ISBN:0198606907]
EOG8W10TV	GO:0017085	1/189	response to insecticide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]
EOG8FFGGT	GO:0016021	11/155	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FFGGT	GO:0000139	6/155	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8FFGGT	GO:0005351	6/155	sugar:proton symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]
EOG8FFGGT	GO:0006810	4/155	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8FFGGT	GO:0016020	1/155	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8FFGGT	GO:0004222	1/155	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8FFGGV	GO:0005739	1/77	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8FFGGV	GO:0006390	1/77	transcription from mitochondrial promoter	biological_process	"The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl]
EOG8NKF9J	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NKF9J	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NKF9B	GO:0008236	2/4	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8HB12D	GO:0004197	1/6	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8HB12D	GO:0006915	1/6	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8CG2QC	GO:0005856	1/4	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8CG2QC	GO:0005737	1/4	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CG2QC	GO:0019898	1/4	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8CG2QG	GO:0030246	1/5	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8P2SKM	GO:0046872	1/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8P2SKM	GO:0003682	1/6	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG876NFT	GO:0003676	52/239	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG876NFT	GO:0046872	1/239	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG876NFT	GO:0005634	1/239	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG876NFT	GO:0003677	1/239	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG876NFP	GO:0005509	2/29	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8KD920	GO:0007155	2/5	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8KD920	GO:0007229	2/5	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG8KD920	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DRCT9	GO:0003824	1/17	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG876NFD	GO:0008270	5/34	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8J13QQ	GO:0016020	21/80	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8J13QQ	GO:0007264	21/80	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8J13QQ	GO:0006184	21/80	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8J13QQ	GO:0005525	21/80	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8J13QQ	GO:0004767	1/80	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG89GNX2	GO:0006508	1/5	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG89GNX2	GO:0008237	1/5	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG89GNX2	GO:0008270	1/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG86DPJM	GO:0004252	2/6	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG89GNX4	GO:0016020	12/79	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG89GNX4	GO:0003824	11/79	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG89GNX4	GO:0008195	1/79	phosphatidate phosphatase activity	molecular_function	"Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [EC:3.1.3.4, GOC:pr]
EOG8ZGRS8	GO:0003676	1/32	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZGRS8	GO:0008270	1/32	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZGRS8	GO:0005634	1/32	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D55CT	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D55CT	GO:0006725	2/5	cellular aromatic compound metabolic process	biological_process	"The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732]
EOG8D55CT	GO:0008198	2/5	ferrous iron binding	molecular_function	"Interacting selectively and non-covalently with ferrous iron, Fe(II)." [GOC:ai]
EOG8D55CT	GO:0016701	2/5	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [GOC:mah]
EOG8HQH01	GO:0003824	12/97	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8HQH01	GO:0016042	1/97	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8HQH01	GO:0016021	1/97	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HQH01	GO:0007126	1/97	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8HQH01	GO:0030717	1/97	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG8HQH01	GO:0043186	1/97	P granule	cellular_component	"A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
EOG8HQH01	GO:0035755	1/97	cardiolipin hydrolase activity	molecular_function	"Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol) to form phosphatidic acid (PA)." [CHEBI:28494, GOC:sp, PMID:17028579, PMID:21397848]
EOG8HQH01	GO:0005739	1/97	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8HQH01	GO:0005741	1/97	mitochondrial outer membrane	cellular_component	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
EOG8HQH01	GO:0048477	1/97	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8HQH01	GO:0031047	1/97	gene silencing by RNA	biological_process	"Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054]
EOG8HQH01	GO:0034587	1/97	piRNA metabolic process	biological_process	"The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]
EOG8HQH01	GO:0046843	1/97	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8HQH03	GO:0003676	2/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HQH03	GO:0046872	2/7	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8KSS1N	GO:0016272	2/5	prefoldin complex	cellular_component	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]
EOG8KSS1N	GO:0006457	2/5	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8HQH0D	GO:0055085	1/5	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8HQH0D	GO:0005741	1/5	mitochondrial outer membrane	cellular_component	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
EOG8ZGRST	GO:0045454	33/123	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8ZGRST	GO:0009055	33/123	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8ZGRST	GO:0015035	33/123	protein disulfide oxidoreductase activity	molecular_function	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]
EOG8ZGRST	GO:0046872	1/123	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG847J7Z	GO:0016021	1/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG847J7Z	GO:0051033	1/6	RNA transmembrane transporter activity	molecular_function	"Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]
EOG847J7Z	GO:0033227	1/6	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8HQH0J	GO:0003964	1/49	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8FN70X	GO:0008270	2/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FN70X	GO:0016568	2/4	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG8FN70X	GO:0005634	2/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NCPTK	GO:0007275	2/5	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8NCPTK	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NCPTK	GO:0006511	2/5	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8NCPTK	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HQH0Z	GO:0019894	1/80	kinesin binding	molecular_function	"Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]
EOG8DRCTK	GO:0016853	1/37	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG876NF6	GO:0044262	3/6	cellular carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
EOG876NF6	GO:0016616	2/6	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG876NF6	GO:0030060	1/6	L-malate dehydrogenase activity	molecular_function	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]
EOG8DRCTD	GO:0004252	2/5	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG85TG37	GO:0003677	2/6	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG85TG37	GO:0005634	2/6	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85TG37	GO:0006355	2/6	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85TG37	GO:0006351	2/6	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG870X02	GO:0016787	29/86	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8DRCTR	GO:0003676	1/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DRCTR	GO:0046872	1/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81ZHQZ	GO:0042787	1/81	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological_process	"The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]
EOG81ZHQZ	GO:0005515	1/81	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG81ZHQZ	GO:0080008	1/81	Cul4-RING E3 ubiquitin ligase complex	cellular_component	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]
EOG81ZHQZ	GO:0016567	1/81	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG81ZHQZ	GO:0043161	1/81	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG8B0150	GO:0047057	2/89	vitamin-K-epoxide reductase (warfarin-sensitive) activity	molecular_function	"Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.1, MetaCyc:1.1.4.1-RXN]
EOG8XH2FJ	GO:0007275	5/15	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8XH2FJ	GO:0008270	5/15	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XH2FJ	GO:0006511	5/15	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8XH2FJ	GO:0005634	5/15	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XH2FJ	GO:0004842	5/15	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8TMTJR	GO:0004252	1/5	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8QRKHV	GO:0008484	24/109	sulfuric ester hydrolase activity	molecular_function	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]
EOG8QRKHV	GO:0008449	2/109	N-acetylglucosamine-6-sulfatase activity	molecular_function	"Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14]
EOG8QRKHV	GO:0005795	1/109	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG8QRKHV	GO:0008045	1/109	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8QRKHV	GO:0016201	1/109	synaptic target inhibition	biological_process	"The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]
EOG8QRKHV	GO:0005783	1/109	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8QRKHV	GO:0045879	1/109	negative regulation of smoothened signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG8QRKHV	GO:0030111	1/109	regulation of Wnt signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]
EOG8QRKHV	GO:0017015	1/109	regulation of transforming growth factor beta receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah]
EOG8QRKHV	GO:0046872	1/109	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QRKHV	GO:0009986	1/109	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8QRKHV	GO:0045880	1/109	positive regulation of smoothened signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG8QRKHV	GO:0042059	1/109	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8XD660	GO:0016787	32/178	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8XD660	GO:0006044	28/178	N-acetylglucosamine metabolic process	biological_process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
EOG8XD660	GO:0004342	28/178	glucosamine-6-phosphate deaminase activity	molecular_function	"Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+)." [EC:3.5.99.6, RHEA:12175]
EOG8XD660	GO:0005975	27/178	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8XD660	GO:0006043	4/178	glucosamine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732]
EOG8XD660	GO:0005737	4/178	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XD660	GO:0006091	4/178	generation of precursor metabolites and energy	biological_process	"The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]
EOG8XD660	GO:0051301	2/178	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8XD660	GO:0016021	1/178	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XD660	GO:0004527	1/178	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8XD660	GO:0046872	1/178	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XD664	GO:0007229	1/5	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG8PP0WX	GO:0005524	55/227	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8PP0WX	GO:0004692	45/227	cGMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
EOG8PP0WX	GO:0030553	14/227	cGMP binding	molecular_function	"Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai]
EOG8PP0WX	GO:0004674	11/227	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8PP0WX	GO:0005952	7/227	cAMP-dependent protein kinase complex	cellular_component	"An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732]
EOG8PP0WX	GO:0008603	7/227	cAMP-dependent protein kinase regulator activity	molecular_function	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]
EOG8PP0WX	GO:0006468	2/227	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8PP0WX	GO:0032095	1/227	regulation of response to food	biological_process	"Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add]
EOG8PP0WX	GO:0005886	1/227	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8PP0WX	GO:0007526	1/227	larval somatic muscle development	biological_process	"The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG8PP0WX	GO:0008345	1/227	larval locomotory behavior	biological_process	"Locomotory behavior in a larval (immature) organism." [GOC:ai]
EOG8PP0WX	GO:0007616	1/227	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8PP0WX	GO:0046959	1/227	habituation	biological_process	"A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089]
EOG8PP0WX	GO:0009744	1/227	response to sucrose	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl]
EOG8PP0WX	GO:0016301	1/227	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8PP0WX	GO:0030536	1/227	larval feeding behavior	biological_process	"Feeding behavior in a larval (immature) organism." [GOC:mah]
EOG8PP0WX	GO:0007631	1/227	feeding behavior	biological_process	"Behavior associated with the intake of food." [GOC:mah]
EOG8PP0WX	GO:0004672	1/227	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8PP0WX	GO:0004690	1/227	cyclic nucleotide-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a cyclic nucleotide." [GOC:mah]
EOG8PP0WX	GO:0008016	1/227	regulation of heart contraction	biological_process	"Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8PP0WX	GO:0007614	1/227	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8XD66D	GO:0016491	2/5	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8XD66D	GO:0003677	1/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XD66V	GO:0003723	14/70	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8XD66V	GO:0009982	14/70	pseudouridine synthase activity	molecular_function	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]
EOG8XD66V	GO:0001522	14/70	pseudouridine synthesis	biological_process	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]
EOG8XD66V	GO:0003796	1/70	lysozyme activity	molecular_function	"Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17]
EOG8XD66T	GO:0016020	1/3	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8R26BJ	GO:0015991	65/111	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8R26BJ	GO:0015078	65/111	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG8R26BJ	GO:0033179	63/111	proton-transporting V-type ATPase, V0 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG8R26BJ	GO:0016787	5/111	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8R26BJ	GO:0000220	2/111	vacuolar proton-transporting V-type ATPase, V0 domain	cellular_component	"The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG8R26BJ	GO:0033181	1/111	plasma membrane proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
EOG8R26BJ	GO:0005886	1/111	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8ZKN1X	GO:0006807	72/199	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG8ZKN1X	GO:0016811	72/199	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]
EOG8ZKN1X	GO:0004435	2/199	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8ZKN1X	GO:0035556	2/199	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8ZKN1X	GO:0006629	2/199	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8ZKN1X	GO:0071110	1/199	histone biotinylation	biological_process	"The modification of a histone by the addition of a biotinyl group." [GOC:rph, PMID:14613969, PMID:19019041]
EOG8ZKN1X	GO:0019898	1/199	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8ZKN1X	GO:0016787	1/199	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8ZKN1X	GO:0009408	1/199	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8ZKN1X	GO:0017159	1/199	pantetheine hydrolase activity	molecular_function	"Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine." [EC:3.5.1.92, RHEA:13448]
EOG8ZKN1X	GO:0018054	1/199	peptidyl-lysine biotinylation	biological_process	"The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117]
EOG8ZKN1G	GO:0008270	3/13	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZKN1G	GO:0003676	3/13	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZKN1G	GO:0005634	3/13	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZKN1G	GO:0046872	1/13	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZKN1J	GO:0046872	2/3	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZKN1J	GO:0003676	2/3	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CVJQW	GO:0003676	2/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85XBB7	GO:0003676	2/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85XBB7	GO:0046872	2/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84TRQ2	GO:0005272	2/11	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG84TRQ2	GO:0016021	2/11	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CVJQD	GO:0046628	1/87	positive regulation of insulin receptor signaling pathway	biological_process	"Any process that increases the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8CVJQD	GO:0005520	1/87	insulin-like growth factor binding	molecular_function	"Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732]
EOG8CVJQD	GO:0046627	1/87	negative regulation of insulin receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8CVJQD	GO:0008340	1/87	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8CVJQD	GO:0007155	1/87	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8CVJQD	GO:0005615	1/87	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG84TRQ8	GO:0003682	1/5	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG84TRQ8	GO:0003677	1/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FR37J	GO:0016021	8/79	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FR37J	GO:0016020	8/79	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Q2GVX	GO:0006629	59/262	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8Q2GVX	GO:0016788	45/262	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG8Q2GVX	GO:0016298	13/262	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG8Q2GVX	GO:0004197	2/262	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8Q2GVX	GO:0004622	1/262	lysophospholipase activity	molecular_function	"Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5]
EOG8Q2GVX	GO:0006909	1/262	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8W10VP	GO:0046872	1/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8616HZ	GO:0007155	51/345	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8616HZ	GO:0005524	32/345	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8616HZ	GO:0004672	17/345	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8616HZ	GO:0004713	14/345	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8616HZ	GO:0004714	7/345	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8616HZ	GO:0004715	1/345	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8616HZ	GO:0007169	1/345	transmembrane receptor protein tyrosine kinase signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
EOG8616HZ	GO:0006468	1/345	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8616HZ	GO:0018108	1/345	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG8616HZ	GO:0016020	1/345	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8FBM6V	GO:0004519	14/108	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8FBM6V	GO:0003964	14/108	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8FBM6V	GO:0006629	14/108	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8FBM6V	GO:0004435	13/108	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8FBM6V	GO:0004871	11/108	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8FBM6V	GO:0035556	9/108	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8FBM6V	GO:0005509	9/108	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8FBM6V	GO:0007264	8/108	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8FBM6V	GO:0005622	8/108	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8FBM6V	GO:0005085	8/108	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8FBM6V	GO:0003723	2/108	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8FBM6V	GO:0008081	1/108	phosphoric diester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]
EOG8VMHZ7	GO:0016021	18/82	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VMHZ7	GO:0016020	6/82	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8VMHZ7	GO:0035208	1/82	positive regulation of hemocyte proliferation	biological_process	"Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG822D09	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG822D09	GO:0022857	1/5	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG822D09	GO:0055085	1/5	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG822D09	GO:0005215	1/5	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG85XBBD	GO:0005615	2/5	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG85XBBD	GO:0008233	1/5	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG85XBBB	GO:0008236	2/3	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG86X1QD	GO:0004553	2/5	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG86X1QD	GO:0005975	2/5	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG84XMWJ	GO:0032258	25/117	CVT pathway	biological_process	"A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast." [PMID:12865942, PMID:15659643]
EOG84XMWJ	GO:0030242	25/117	pexophagy	biological_process	"The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions." [GOC:autophagy, PMID:10547367, PMID:20083110]
EOG84XMWJ	GO:0006914	8/117	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG84XMWJ	GO:0016236	1/117	macroautophagy	biological_process	"The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure.  Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464]
EOG84XMWJ	GO:0010506	1/117	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG84XMWJ	GO:0014067	1/117	negative regulation of phosphatidylinositol 3-kinase signaling	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef]
EOG84XMWJ	GO:0042060	1/117	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG84XMWJ	GO:0035069	1/117	larval midgut histolysis	biological_process	"The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683]
EOG86X1QS	GO:0016021	1/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RR8Z0	GO:0055085	1/4	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8RR8Z0	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RR8Z3	GO:0003676	15/41	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RR8Z3	GO:0005634	15/41	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RR8Z3	GO:0008270	14/41	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RR8Z3	GO:0046872	3/41	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RR8Z3	GO:0003677	3/41	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RR8Z3	GO:0006098	1/41	pentose-phosphate shunt	biological_process	"The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]
EOG8RR8Z3	GO:0006355	1/41	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8RR8Z3	GO:0003678	1/41	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8RR8Z3	GO:0005524	1/41	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8RR8Z3	GO:0042555	1/41	MCM complex	cellular_component	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]
EOG8RR8Z3	GO:0006270	1/41	DNA replication initiation	biological_process	"The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194]
EOG8RR8Z3	GO:0017057	1/41	6-phosphogluconolactonase activity	molecular_function	"Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+)." [EC:3.1.1.31, RHEA:12559]
EOG8F20H1	GO:0003723	51/188	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8F20H1	GO:0003743	5/188	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8F20H1	GO:0000082	2/188	G1/S transition of mitotic cell cycle	biological_process	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]
EOG8F20H1	GO:0000340	2/188	RNA 7-methylguanosine cap binding	molecular_function	"Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc]
EOG8F20H1	GO:0006413	1/188	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG8F20H1	GO:0035071	1/188	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8F20H1	GO:0007067	1/188	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8F20H1	GO:0007140	1/188	male meiosis	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
EOG8F20H1	GO:0048102	1/188	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8F20H1	GO:0016281	1/188	eukaryotic translation initiation factor 4F complex	cellular_component	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:8449919]
EOG8F20H1	GO:0008315	1/188	meiotic G2/MI transition	biological_process	"The cell cycle process in which a cell progresses from meiotic prophase to metaphase I." [PMID:15088480]
EOG8F20H1	GO:0008190	1/188	eukaryotic initiation factor 4E binding	molecular_function	"Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation." [ISBN:0198506732]
EOG8F20H1	GO:0007095	1/188	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8F20H1	GO:0000022	1/188	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8F20H1	GO:0048515	1/188	spermatid differentiation	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid]
EOG8F20H1	GO:0005829	1/188	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8F20H1	GO:0006412	1/188	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8F20H1	GO:0007283	1/188	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8F20H1	GO:0007052	1/188	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8F20H6	GO:0043874	21/84	acireductone synthase activity	molecular_function	"Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate." [EC:3.1.3.77]
EOG8F20H6	GO:0019509	21/84	L-methionine biosynthetic process from methylthioadenosine	biological_process	"The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361]
EOG8F20H6	GO:0000287	21/84	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8F20H6	GO:0005737	16/84	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8F20H6	GO:0005634	16/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8F20H6	GO:0043716	1/84	2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity	molecular_function	"Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene." [EC:3.1.3.77, IMG:01681, MetaCyc:R83-RXN]
EOG8F20H6	GO:0003677	1/84	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8F20H6	GO:0019284	1/84	L-methionine biosynthetic process from S-adenosylmethionine	biological_process	"The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including S-adenosylmethionine." [GOC:go_curators]
EOG8F20H6	GO:0043715	1/84	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity	molecular_function	"Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate. 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P." [MetaCyc:R82-RXN]
EOG8CG2PS	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CG2PS	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CG2PS	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8P2SHP	GO:0016491	3/4	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8CJXX0	GO:0005083	25/115	GTPase regulator activity	molecular_function	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
EOG8CJXX0	GO:0005524	24/115	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CJXX0	GO:0004674	13/115	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8CJXX0	GO:0004672	11/115	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8CJXX0	GO:0046330	1/115	positive regulation of JNK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8CJXX0	GO:0032006	1/115	regulation of TOR signaling	biological_process	"Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8CJXX0	GO:0007254	1/115	JNK cascade	biological_process	"An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974]
EOG8CJXX0	GO:0070328	1/115	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG8CJXX0	GO:0016301	1/115	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8CJXX0	GO:0006468	1/115	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8CJXX0	GO:0007030	1/115	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8CJXX0	GO:0006915	1/115	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8CJXX0	GO:0031931	1/115	TORC1 complex	cellular_component	"A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787]
EOG8CJXX0	GO:0046626	1/115	regulation of insulin receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8CJXX0	GO:0004702	1/115	receptor signaling protein serine/threonine kinase activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah]
EOG8CJXX0	GO:0040009	1/115	regulation of growth rate	biological_process	"Any process that modulates the rate of growth of all or part of an organism." [GOC:mah]
EOG8CJXX0	GO:0043065	1/115	positive regulation of apoptotic process	biological_process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8CJXX0	GO:0005737	1/115	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CJXX0	GO:0032008	1/115	positive regulation of TOR signaling	biological_process	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8CJXX0	GO:0008361	1/115	regulation of cell size	biological_process	"Any process that modulates the size of a cell." [GOC:go_curators]
EOG8CJXX0	GO:0048149	1/115	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8CJXX0	GO:0042059	1/115	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8P2SHZ	GO:0005509	2/5	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8F4VS8	GO:0016021	1/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84QWF9	GO:0016021	1/41	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84QWF9	GO:0005515	1/41	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8P2SH5	GO:0005634	37/108	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8P2SH5	GO:0043565	37/108	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8P2SH5	GO:0003700	35/108	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8P2SH5	GO:0045944	2/108	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8P2SH5	GO:0001077	2/108	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG8P2SH5	GO:0003677	1/108	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8P2SH5	GO:0007417	1/108	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8P2SH5	GO:0006351	1/108	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8P2SH5	GO:0035220	1/108	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8P2SH5	GO:0036022	1/108	limb joint morphogenesis	biological_process	"The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner." [GOC:bf]
EOG8P2SH5	GO:0007275	1/108	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8P2SH5	GO:0048699	1/108	generation of neurons	biological_process	"The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]
EOG8P2SH5	GO:0007419	1/108	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8P2SH5	GO:0048813	1/108	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8P2SH5	GO:0014019	1/108	neuroblast development	biological_process	"The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585]
EOG8P2SH5	GO:0007402	1/108	ganglion mother cell fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
EOG8P2SH5	GO:0007389	1/108	pattern specification process	biological_process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
EOG8P2SH5	GO:0007398	1/108	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG8P2SH5	GO:0006355	1/108	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8QFZW3	GO:0003700	2/15	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8QFZW3	GO:0043565	2/15	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8QFZW3	GO:0005634	2/15	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TXF6D	GO:0006807	29/98	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG8TXF6D	GO:0016810	27/98	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
EOG8TXF6D	GO:0003837	3/98	beta-ureidopropionase activity	molecular_function	"Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6]
EOG8TXF6D	GO:0006208	1/98	pyrimidine nucleobase catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [CHEBI:26432, GOC:go_curators]
EOG8TXF6D	GO:0006207	1/98	'de novo' pyrimidine nucleobase biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]
EOG8F4VSP	GO:0008270	5/34	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8F4VSP	GO:0003700	5/34	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8F4VSP	GO:0005634	5/34	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8F4VSP	GO:0043565	5/34	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8F4VSP	GO:0006351	1/34	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8XKXNC	GO:0006904	8/47	vesicle docking involved in exocytosis	biological_process	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]
EOG84XN1F	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84XN1F	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XKXNG	GO:0050660	5/13	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8XKXNG	GO:0008812	5/13	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG8XKXNG	GO:0006066	5/13	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG8M680V	GO:0032934	24/61	sterol binding	molecular_function	"Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [CHEBI:15889, GOC:mah]
EOG8F4VSG	GO:0016491	199/611	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8F4VSG	GO:0047886	2/611	farnesol dehydrogenase activity	molecular_function	"Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH." [EC:1.1.1.216, RHEA:14700]
EOG8F4VSG	GO:0004316	1/611	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
EOG8F4VSG	GO:0016063	1/611	rhodopsin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
EOG8F4VSG	GO:0022008	1/611	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8TXF6P	GO:0006629	4/6	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8TXF6P	GO:0005576	4/6	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8TXF6P	GO:0016787	2/6	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8TXF6P	GO:0003824	2/6	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8TXF6Q	GO:0008270	1/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TXF6Q	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8TXF6Q	GO:0005634	1/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TXF6W	GO:0016020	10/48	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8R52GW	GO:0016021	27/113	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8R52GW	GO:0055085	27/113	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8M680D	GO:0016706	1/59	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG8F4VSH	GO:0016021	8/48	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F20HN	GO:0003677	1/3	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8F20HN	GO:0005634	1/3	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PK4NX	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PK4NX	GO:0005524	1/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8PK4NX	GO:0046872	1/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8PK4NX	GO:0019829	1/5	cation-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]
EOG8T4G98	GO:0046872	7/51	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8T4G98	GO:0006886	6/51	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8F20HQ	GO:0008270	9/89	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RR8ZB	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RR8ZB	GO:0022857	1/4	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8MD0D6	GO:0000398	27/98	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8MD0D6	GO:0097157	27/98	pre-mRNA intronic binding	molecular_function	"Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624]
EOG8MD0D6	GO:0005681	26/98	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8MD0D6	GO:0071013	1/98	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8MD0D6	GO:0016787	1/98	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8MD0D6	GO:0004386	1/98	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8MD0D6	GO:0071011	1/98	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8W10V3	GO:0007606	1/64	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8W10V3	GO:0005515	1/64	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8X3KFJ	GO:0003968	1/92	RNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah]
EOG8X3KFW	GO:0005524	27/97	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X3KFW	GO:0004674	25/97	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8X3KFW	GO:0004672	3/97	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8X3KFW	GO:0004712	2/97	protein serine/threonine/tyrosine kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]
EOG8X3KFW	GO:0016772	2/97	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8X3KFW	GO:0071011	1/97	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8X3KFW	GO:0022008	1/97	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8X3KFW	GO:0008360	1/97	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8X3KFW	GO:0000398	1/97	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8X3KFW	GO:0071013	1/97	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8X3KFW	GO:0006468	1/97	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8X3KFW	GO:0007155	1/97	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8X3KFS	GO:0000287	2/5	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8X3KFS	GO:0004743	2/5	pyruvate kinase activity	molecular_function	"Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40]
EOG8X3KFS	GO:0030955	2/5	potassium ion binding	molecular_function	"Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah]
EOG8X3KFS	GO:0006096	2/5	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8KD91C	GO:0080019	36/163	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8RFP70	GO:0005525	2/4	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8RFP70	GO:0005874	2/4	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8RFP70	GO:0003924	2/4	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8RFP70	GO:0005200	2/4	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8RFP70	GO:0051258	2/4	protein polymerization	biological_process	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
EOG8RFP70	GO:0005737	2/4	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RFP70	GO:0007017	2/4	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG87WR3K	GO:0016884	23/84	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	molecular_function	"Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532]
EOG87WR3K	GO:0016740	2/84	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG87WR3K	GO:0004040	1/84	amidase activity	molecular_function	"Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4]
EOG87WR3K	GO:0005811	1/84	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG82588D	GO:0070176	27/86	DRM complex	cellular_component	"A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification." [PMID:17075059]
EOG82588D	GO:0007049	27/86	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG82588D	GO:0006351	27/86	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG82588D	GO:0000791	1/86	euchromatin	cellular_component	"A dispersed and relatively uncompacted form of chromatin." [GOC:elh]
EOG82588D	GO:0048749	1/86	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG82588D	GO:0005700	1/86	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG82588D	GO:0031523	1/86	Myb complex	cellular_component	"A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624]
EOG82588D	GO:0000122	1/86	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG82588D	GO:0005634	1/86	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80P6QB	GO:0005856	1/66	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG80P6QB	GO:0009966	1/66	regulation of signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]
EOG80P6QB	GO:0008360	1/66	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG80P6QB	GO:0005198	1/66	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG80P6QB	GO:0005737	1/66	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG80P6QB	GO:0005886	1/66	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8KD91Q	GO:0050909	56/82	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8KD91Q	GO:0016021	56/82	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KD91Q	GO:0005886	56/82	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8KD91Q	GO:0008527	3/82	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8KD91Q	GO:0050912	3/82	detection of chemical stimulus involved in sensory perception of taste	biological_process	"The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8KD91Q	GO:0008049	2/82	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8KD91Q	GO:0016544	1/82	male courtship behavior, tapping to detect pheromone	biological_process	"The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827]
EOG8Q87BS	GO:0016021	3/11	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Q87BS	GO:0005328	3/11	neurotransmitter:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
EOG8Q87BP	GO:0051287	44/136	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8Q87BP	GO:0048038	44/136	quinone binding	molecular_function	"Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732]
EOG8Q87BP	GO:0016651	40/136	oxidoreductase activity, acting on NAD(P)H	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8Q87BP	GO:0003954	2/136	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8Q87BP	GO:0008137	2/136	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8Q87BP	GO:0005739	1/136	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8Q87BP	GO:0048812	1/136	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8Q87BP	GO:0046331	1/136	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG80P6Q1	GO:0016021	2/83	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG825880	GO:0004252	24/106	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG825880	GO:0008237	1/106	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG825880	GO:0016020	1/106	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG825880	GO:0008241	1/106	peptidyl-dipeptidase activity	molecular_function	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]
EOG825880	GO:0006508	1/106	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG825880	GO:0008233	1/106	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8RFP7S	GO:0003824	35/102	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8RFP7S	GO:0016787	2/102	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8RFP7S	GO:0008704	1/102	5-carboxymethyl-2-hydroxymuconate delta-isomerase activity	molecular_function	"Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate." [EC:5.3.3.10]
EOG8RFP7S	GO:0018800	1/102	5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity	molecular_function	"Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2." [EC:4.1.1.68]
EOG8RFP7V	GO:0016021	12/199	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RFP7V	GO:0007519	1/199	skeletal muscle tissue development	biological_process	"The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
EOG8RFP7V	GO:0016020	1/199	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RFP7V	GO:0007520	1/199	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG8GMXD3	GO:0016021	1/106	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CVJMX	GO:0004553	2/5	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8CVJMX	GO:0005975	2/5	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8CVJMX	GO:0030246	2/5	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8CVJMX	GO:0007155	1/5	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8Z91DB	GO:0006955	17/36	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8Z91DB	GO:0005044	17/36	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8Z91DB	GO:0030247	17/36	polysaccharide binding	molecular_function	"Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah]
EOG8CVJMR	GO:0016772	33/148	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8CVJMR	GO:0016301	3/148	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG83V2BB	GO:0003682	1/3	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8Z652B	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z652B	GO:0003676	1/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83V2BF	GO:0005509	6/47	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG83V2BD	GO:0006338	1/105	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG83V2BD	GO:0046872	1/105	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83V2BD	GO:0003677	1/105	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG83V2BD	GO:0005634	1/105	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8MD0DV	GO:0004222	27/147	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8MD0DV	GO:0008270	19/147	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MD0DV	GO:0004190	1/147	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8K6JKS	GO:0046872	3/10	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8K6JKS	GO:0003676	1/10	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K6JKS	GO:0005634	1/10	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VHNM7	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VHNM7	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VHNM7	GO:0003676	1/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W10WW	GO:0016021	1/47	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W10WW	GO:0015299	1/47	solute:proton antiporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]
EOG8HQH11	GO:0004930	1/17	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8HQH11	GO:0016021	1/17	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8K6JKH	GO:0051056	2/110	regulation of small GTPase mediated signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
EOG8K6JKH	GO:0005622	2/110	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8K6JKH	GO:0005096	2/110	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8K6JKH	GO:0032851	1/110	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8K6JKH	GO:0000139	1/110	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8K6JKH	GO:0035418	1/110	protein localization to synapse	biological_process	"Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf]
EOG8K6JKH	GO:0060078	1/110	regulation of postsynaptic membrane potential	biological_process	"Any process that modulates the potential difference across a post-synaptic membrane." [GOC:dph, GOC:ef]
EOG8K6JKH	GO:0017112	1/110	Rab guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8K6JKH	GO:0016021	1/110	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8K6JKH	GO:0017137	1/110	Rab GTPase binding	molecular_function	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG8K6JKH	GO:0016023	1/110	cytoplasmic membrane-bounded vesicle	cellular_component	"A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
EOG8K6JKH	GO:0045467	1/110	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8K6JKH	GO:0005794	1/110	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8K6JKH	GO:0007411	1/110	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8K6JKH	GO:0050808	1/110	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG8K6JKH	GO:0032483	1/110	regulation of Rab protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]
EOG8MD0DM	GO:0015671	1/79	oxygen transport	biological_process	"The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8MD0DM	GO:0019825	1/79	oxygen binding	molecular_function	"Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl]
EOG8MD0DM	GO:0005506	1/79	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8MD0DM	GO:0020037	1/79	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8FN6Z2	GO:0004555	58/173	alpha,alpha-trehalase activity	molecular_function	"Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28]
EOG8FN6Z2	GO:0005991	58/173	trehalose metabolic process	biological_process	"The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]
EOG8FN6Z2	GO:0003824	1/173	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8FN6Z2	GO:0015927	1/173	trehalase activity	molecular_function	"Catalysis of the hydrolysis of trehalose or a trehalose derivative." [GOC:ai]
EOG8XD65H	GO:0008270	2/6	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XD65H	GO:0003676	2/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XD65H	GO:0005634	2/6	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XD65Z	GO:0016020	82/167	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XD65Z	GO:0003824	75/167	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8XD65Z	GO:0008195	8/167	phosphatidate phosphatase activity	molecular_function	"Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [EC:3.1.3.4, GOC:pr]
EOG8XD65Z	GO:0016311	5/167	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG8XD65Z	GO:0045177	2/167	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8XD65Z	GO:0007280	2/167	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG8XD65Z	GO:0005886	2/167	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8XD65Z	GO:0035234	2/167	ectopic germ cell programmed cell death	biological_process	"Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944]
EOG8XD65Z	GO:0035233	2/167	germ cell repulsion	biological_process	"The directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue." [PMID:12885551]
EOG8XD65Z	GO:0008354	2/167	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8XD65Z	GO:0007277	1/167	pole cell development	biological_process	"The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jid]
EOG8XD65Z	GO:0005319	1/167	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG8XD65Z	GO:0007602	1/167	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG8XD65Z	GO:0004252	1/167	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8XD65Z	GO:0050829	1/167	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8XD65Z	GO:0042803	1/167	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8XD65Z	GO:0005918	1/167	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG8XD65Z	GO:0019991	1/167	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG8XD65Z	GO:0016021	1/167	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XD65Z	GO:0016787	1/167	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8XD65Z	GO:0045824	1/167	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG8XD65Z	GO:0090175	1/167	regulation of establishment of planar polarity	biological_process	"Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8XD65Z	GO:0007424	1/167	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8XD65Z	GO:0042577	1/167	lipid phosphatase activity	molecular_function	"Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl]
EOG8XD65Z	GO:0007281	1/167	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8XD65Z	GO:0006869	1/167	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG8XD65Z	GO:0006629	1/167	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8XD65Z	GO:0009880	1/167	embryonic pattern specification	biological_process	"The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
EOG8XD65Z	GO:0016791	1/167	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG8XD65X	GO:0004984	25/128	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8XD65X	GO:0005549	25/128	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8XD65X	GO:0016021	21/128	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XD65X	GO:0004930	21/128	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8XD65X	GO:0005886	12/128	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8XD65X	GO:0016020	4/128	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8SJ7WF	GO:0016491	61/186	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8SJ7WF	GO:0004303	2/186	estradiol 17-beta-dehydrogenase activity	molecular_function	"Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62]
EOG8SJ7WF	GO:0006909	1/186	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8SJ7WF	GO:0005783	1/186	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8SJ7WF	GO:0008285	1/186	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8SJ7WF	GO:0007030	1/186	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8J13PJ	GO:0016021	33/103	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J13PJ	GO:0046923	33/103	ER retention sequence binding	molecular_function	"Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER." [GOC:ai]
EOG8J13PJ	GO:0006621	33/103	protein retention in ER lumen	biological_process	"The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550]
EOG8J13PJ	GO:0015031	29/103	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8J13PJ	GO:0005783	29/103	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8J13PJ	GO:0046872	1/103	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8J13PJ	GO:0003676	1/103	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8B0164	GO:0005509	2/6	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8BS031	GO:0007018	1/42	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8BS031	GO:0003777	1/42	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8WWV20	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8FBM7S	GO:0016021	21/80	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FBM7J	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FBM7J	GO:0055085	2/5	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8FBM7J	GO:0005215	2/5	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG83FKB2	GO:0004177	1/4	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG83FKB2	GO:0008237	1/4	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG83FKB2	GO:0008270	1/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84F8QS	GO:0008234	10/52	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8B2WBG	GO:0004252	7/69	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8B2WBG	GO:0016020	6/69	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8B2WBG	GO:0005044	6/69	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG84TRPH	GO:0005975	41/141	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG84TRPH	GO:0016757	39/141	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG84TRPH	GO:0008344	1/141	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG84TRPH	GO:0033842	1/141	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244]
EOG84TRPH	GO:0005794	1/141	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG84TRPH	GO:0007528	1/141	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG84TRPH	GO:0009247	1/141	glycolipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators]
EOG84TRPH	GO:0003945	1/141	N-acetyllactosamine synthase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90]
EOG84TRPH	GO:0008376	1/141	acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]
EOG84TRPH	GO:0006044	1/141	N-acetylglucosamine metabolic process	biological_process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
EOG84TRPS	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84TRPS	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG834ZN0	GO:0043565	2/5	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG834ZN0	GO:0006351	2/5	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG834ZN0	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG834ZN0	GO:0003700	2/5	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG834ZN0	GO:0003707	2/5	steroid hormone receptor activity	molecular_function	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
EOG834ZN0	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83R62M	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83R62M	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81ZHRV	GO:0016021	3/7	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81ZHRV	GO:0022857	3/7	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG81ZHRV	GO:0008643	1/7	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG85HVD9	GO:0005549	8/23	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG85HVD9	GO:0006810	7/23	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG85HVD9	GO:0007608	1/23	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG85HVD9	GO:0050896	1/23	response to stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
EOG8JMB3H	GO:0005886	4/45	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8JMB3H	GO:0005509	4/45	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8JMB3H	GO:0016021	4/45	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JMB3H	GO:0007156	4/45	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8JMB3H	GO:0004022	1/45	alcohol dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
EOG81ZHRG	GO:0046872	4/10	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81ZHRG	GO:0003676	3/10	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG81ZHRG	GO:0003677	2/10	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81ZHRG	GO:0008270	1/10	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81ZHRG	GO:0005634	1/10	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FBM74	GO:0005089	2/5	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8MKQW2	GO:0003676	3/252	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MKQW2	GO:0000166	3/252	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8MKQW2	GO:0003677	2/252	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8MKQW2	GO:0006360	1/252	transcription from RNA polymerase I promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
EOG8MKQW2	GO:0042302	1/252	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8MKQW2	GO:0005201	1/252	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG8MKQW2	GO:0031012	1/252	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8MKQW2	GO:0000226	1/252	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8MKQW2	GO:0007304	1/252	chorion-containing eggshell formation	biological_process	"The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8MKQW2	GO:0016787	1/252	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8MKQW2	GO:0022008	1/252	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8MKQW2	GO:0005736	1/252	DNA-directed RNA polymerase I complex	cellular_component	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8MKQW2	GO:0042600	1/252	chorion	cellular_component	"A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
EOG8MKQW2	GO:0005874	1/252	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8QJV2D	GO:0009253	22/121	peptidoglycan catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
EOG8QJV2D	GO:0008745	22/121	N-acetylmuramoyl-L-alanine amidase activity	molecular_function	"Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]
EOG8QJV2D	GO:0046872	1/121	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG883GNT	GO:0003964	338/1363	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG883GNT	GO:0003723	333/1363	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG883GNT	GO:0008270	44/1363	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG883GNT	GO:0003676	19/1363	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG883GNT	GO:0004519	4/1363	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG883GNT	GO:0004523	3/1363	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG883GNT	GO:0006511	2/1363	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG883GNT	GO:0046872	2/1363	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG883GNT	GO:0005634	1/1363	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG883GNT	GO:0016020	1/1363	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG883GNT	GO:0034450	1/1363	ubiquitin-ubiquitin ligase activity	molecular_function	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]
EOG883GNT	GO:0005524	1/1363	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG883GNT	GO:0004674	1/1363	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG883GNT	GO:0015074	1/1363	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG883GNT	GO:0006281	1/1363	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG883GNT	GO:0000723	1/1363	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG883GNT	GO:0003677	1/1363	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG883GNT	GO:0000786	1/1363	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG883GNT	GO:0003678	1/1363	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG883GNT	GO:0016758	1/1363	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG883GNT	GO:0006334	1/1363	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG883GNT	GO:0000151	1/1363	ubiquitin ligase complex	cellular_component	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
EOG8NGK1G	GO:0004725	25/171	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8NGK1G	GO:0050254	2/171	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8NGK1G	GO:0001700	1/171	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8NGK1G	GO:0005001	1/171	transmembrane receptor protein tyrosine phosphatase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8NGK1G	GO:0008201	1/171	heparin binding	molecular_function	"Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]
EOG8NGK1G	GO:0048675	1/171	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG8NGK1G	GO:0005925	1/171	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8NGK1G	GO:0005515	1/171	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8NGK1G	GO:0005875	1/171	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8NGK1G	GO:0016021	1/171	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NGK1G	GO:0007412	1/171	axon target recognition	biological_process	"The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437]
EOG8NGK1G	GO:0048841	1/171	regulation of axon extension involved in axon guidance	biological_process	"Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]
EOG8NGK1G	GO:0007399	1/171	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8NGK1G	GO:0035335	1/171	peptidyl-tyrosine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
EOG8NGK1G	GO:0030424	1/171	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8NGK1G	GO:0032093	1/171	SAM domain binding	molecular_function	"Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230]
EOG8NGK1G	GO:0005886	1/171	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8NGK1G	GO:0048477	1/171	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8NGK1G	GO:0007155	1/171	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8NGK1G	GO:0008045	1/171	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8NGK1G	GO:0045467	1/171	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8NGK1G	GO:0007411	1/171	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8NGK1G	GO:0051124	1/171	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8NGK1G	GO:0008594	1/171	photoreceptor cell morphogenesis	biological_process	"The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
EOG8NGK1G	GO:0008360	1/171	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8NGK1G	GO:0016162	1/171	cellulose 1,4-beta-cellobiosidase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91]
EOG8NGK1G	GO:0031290	1/171	retinal ganglion cell axon guidance	biological_process	"The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs]
EOG8NGK1G	GO:0006470	1/171	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8QJV2N	GO:0008270	2/6	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83N9T2	GO:0006783	26/87	heme biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl]
EOG83N9T2	GO:0004325	26/87	ferrochelatase activity	molecular_function	"Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX." [EC:4.99.1.1, RHEA:22587]
EOG83N9T2	GO:0005875	1/87	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG83N9T2	GO:0051537	1/87	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG83N9T2	GO:0005743	1/87	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG83N9T2	GO:0046872	1/87	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TXF5R	GO:0007165	1/27	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8TXF5R	GO:0005622	1/27	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8NGK1T	GO:0016021	35/159	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NGK1T	GO:0055085	35/159	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8QJV2Z	GO:0007606	16/1207	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8QJV2Z	GO:0005515	9/1207	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QJV2Z	GO:0016021	3/1207	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QJV2Z	GO:0008039	1/1207	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8QJV2Z	GO:0050914	1/1207	sensory perception of salty taste	biological_process	"The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8QJV2Z	GO:0002115	1/1207	store-operated calcium entry	biological_process	"A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991]
EOG8QJV2Z	GO:0035199	1/1207	salt aversion	biological_process	"The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf]
EOG8QJV2Z	GO:0048149	1/1207	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8QJV2Z	GO:0005886	1/1207	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8M681F	GO:0003677	1/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG898XFX	GO:0004252	2/4	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8GJ23M	GO:0008440	20/60	inositol-1,4,5-trisphosphate 3-kinase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11023]
EOG8GJ23M	GO:0000823	2/60	inositol-1,4,5-trisphosphate 6-kinase activity	molecular_function	"Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+)." [MetaCyc:2.7.1.151-RXN]
EOG8GJ23M	GO:0046427	1/60	positive regulation of JAK-STAT cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG8GJ23M	GO:0032958	1/60	inositol phosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, CHEBI:25448, GOC:mah]
EOG8GJ23M	GO:0047326	1/60	inositol tetrakisphosphate 5-kinase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.140, MetaCyc:2.7.1.140-RXN]
EOG8GJ23M	GO:0016310	1/60	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG8GJ23M	GO:0005654	1/60	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG8F4VRN	GO:0005509	2/4	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8F4VRN	GO:0048208	1/4	COPII vesicle coating	biological_process	"The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:mah, GOC:tb, ISBN:0716731363, PMID:10219233]
EOG8F4VRN	GO:0000139	1/4	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8KWN70	GO:0042765	12/59	GPI-anchor transamidase complex	cellular_component	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]
EOG8KWN70	GO:0016255	12/59	attachment of GPI anchor to protein	biological_process	"A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595]
EOG82FVXS	GO:0016758	251/467	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG82FVXS	GO:0015020	15/467	glucuronosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17]
EOG82FVXS	GO:0030259	7/467	lipid glycosylation	biological_process	"Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah]
EOG82FVXS	GO:0016999	4/467	antibiotic metabolic process	biological_process	"The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2]
EOG82FVXS	GO:0030246	4/467	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG82FVXS	GO:0003851	1/467	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45]
EOG8F20KR	GO:0042302	4/6	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8X9B0X	GO:0000062	71/241	fatty-acyl-CoA binding	molecular_function	"Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732]
EOG8X9B0X	GO:0034464	24/241	BBSome	cellular_component	"A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [GOC:BHF, PMID:17574030]
EOG8X9B0X	GO:0035058	24/241	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG8X9B0X	GO:0004402	2/241	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8X9B0X	GO:0042384	1/241	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8X9B0X	GO:0008289	1/241	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG8X9B0X	GO:0006810	1/241	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8X9B0X	GO:0005929	1/241	cilium	cellular_component	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:kmv, GOC:vw, ISBN:0198547684]
EOG8X9B0X	GO:0042049	1/241	cellular acyl-CoA homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of acyl-CoA within a cell or between a cell and its external environment." [GOC:ai, GOC:dph, GOC:tb]
EOG8X9B0X	GO:0004165	1/241	dodecenoyl-CoA delta-isomerase activity	molecular_function	"Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [EC:5.3.3.8]
EOG85B3WC	GO:0006629	4/28	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG85B3WC	GO:0005576	4/28	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG85B3WC	GO:0016787	3/28	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG85B3WC	GO:0004806	1/28	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG8CVJRH	GO:0080019	2/7	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8KWN7C	GO:0022857	2/6	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8KWN7C	GO:0016021	2/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C8B8N	GO:0003700	9/34	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8C8B8N	GO:0005634	7/34	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8C8B8N	GO:0000976	5/34	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8C8B8N	GO:0043565	4/34	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8C8B8N	GO:0004000	1/34	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8C8B8N	GO:0007275	1/34	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG83N9TJ	GO:0005506	404/1184	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG83N9TJ	GO:0020037	404/1184	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG83N9TJ	GO:0016705	391/1184	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG83N9TJ	GO:0004497	374/1184	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG83N9TJ	GO:0005789	17/1184	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG83N9TJ	GO:0070330	6/1184	aromatase activity	molecular_function	"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
EOG83N9TJ	GO:0052869	6/1184	arachidonic acid omega-hydroxylase activity	molecular_function	"Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid." [KEGG:R07041]
EOG83N9TJ	GO:0018685	6/1184	alkane 1-monooxygenase activity	molecular_function	"Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3]
EOG83N9TJ	GO:0016539	3/1184	intein-mediated protein splicing	biological_process	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]
EOG83N9TJ	GO:0007165	2/1184	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG83N9TJ	GO:0005622	2/1184	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG83N9TJ	GO:0007618	1/1184	mating	biological_process	"The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546]
EOG83N9TJ	GO:0005201	1/1184	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG83N9TJ	GO:0005581	1/1184	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG83N9TJ	GO:0050051	1/1184	leukotriene-B4 20-monooxygenase activity	molecular_function	"Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN]
EOG83N9TJ	GO:0052871	1/1184	alpha-tocopherol omega-hydroxylase activity	molecular_function	"Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003]
EOG83N9TJ	GO:0006629	1/1184	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG83N9TJ	GO:0005737	1/1184	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83N9TJ	GO:0005811	1/1184	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8C8B8W	GO:0003676	1/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8C8B8W	GO:0008270	1/6	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XWJBJ	GO:0005198	1/34	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8CVJNG	GO:0008270	2/6	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CVJNG	GO:0005634	2/6	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CVJNG	GO:0003677	2/6	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG88PQ36	GO:0043565	1/4	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG88PQ36	GO:0005634	1/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88PQ36	GO:0003700	1/4	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG82VBZ1	GO:0003964	6/161	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG82VBZ1	GO:0003676	6/161	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82VBZ1	GO:0003723	6/161	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG82VBZ1	GO:0008270	4/161	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG82VBZ1	GO:0015074	3/161	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG82VBZ1	GO:0004190	2/161	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8QFZTP	GO:0005215	2/5	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8QFZTP	GO:0055085	2/5	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8QFZTP	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8H48HN	GO:0016021	2/10	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8H48HN	GO:0005216	2/10	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG869T8X	GO:0016021	2/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG869T8X	GO:0022857	2/6	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8W6RCD	GO:0031083	1/51	BLOC-1 complex	cellular_component	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]
EOG841STT	GO:0006030	2/8	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG841STT	GO:0005576	2/8	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG841STT	GO:0008061	2/8	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG869T8J	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W10V7	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W10V7	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8BK7K0	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG869T8C	GO:0016021	27/94	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG869T8C	GO:0004872	1/94	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG80CKX6	GO:0016021	222/694	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80CKX6	GO:0003333	7/694	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG80CKX6	GO:0015171	7/694	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG80CKX6	GO:0040007	2/694	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG80CKX6	GO:0044719	1/694	regulation of imaginal disc-derived wing size	biological_process	"Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
EOG80CKX6	GO:0022008	1/694	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8Z6531	GO:0016021	3/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z6531	GO:0004180	1/91	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8Z6531	GO:0004721	1/91	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG82NMGR	GO:0005739	21/66	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG82NMGR	GO:0004129	21/66	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8FR36B	GO:0008812	1/3	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG8FR36B	GO:0050660	1/3	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8FR36B	GO:0006066	1/3	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG8QFZT5	GO:0016021	40/173	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QFZT5	GO:0055085	40/173	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8QFZT5	GO:0003824	1/173	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG89PDCD	GO:0016021	3/105	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89PDCD	GO:0004721	2/105	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG89PDCD	GO:0035159	1/105	regulation of tube length, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
EOG89PDCD	GO:0007424	1/105	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG89PDCD	GO:0035151	1/105	regulation of tube size, open tracheal system	biological_process	"Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]
EOG89PDCD	GO:0008045	1/105	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG80P6PG	GO:0003735	22/82	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG80P6PG	GO:0005840	21/82	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG80P6PG	GO:0003743	11/82	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG80P6PG	GO:0006412	11/82	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG80P6PG	GO:0005762	1/82	mitochondrial large ribosomal subunit	cellular_component	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
EOG89PDCR	GO:0006520	45/105	cellular amino acid metabolic process	biological_process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]
EOG89PDCR	GO:0004067	26/105	asparaginase activity	molecular_function	"Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]
EOG89PDCR	GO:0004622	3/105	lysophospholipase activity	molecular_function	"Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5]
EOG8G7FCR	GO:0005975	35/112	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8G7FCR	GO:0004553	34/112	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8G7FCR	GO:0032450	1/112	maltose alpha-glucosidase activity	molecular_function	"Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141]
EOG8NCPV5	GO:0004672	1/3	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8NCPV5	GO:0005524	1/3	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82C0PZ	GO:0006066	2/10	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG82C0PZ	GO:0008812	2/10	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG82C0PZ	GO:0050660	2/10	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG82C0PV	GO:0003676	8/28	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82C0PV	GO:0008270	4/28	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG82C0PV	GO:0046872	4/28	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82C0PV	GO:0005634	4/28	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HQH24	GO:0006879	2/3	cellular iron ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah]
EOG8HQH24	GO:0006826	2/3	iron ion transport	biological_process	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8HQH24	GO:0008199	2/3	ferric iron binding	molecular_function	"Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai]
EOG8G7FCB	GO:0016021	42/190	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G7FCB	GO:0008271	30/190	secondary active sulfate transmembrane transporter activity	molecular_function	"Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
EOG8G7FCB	GO:0015116	13/190	sulfate transmembrane transporter activity	molecular_function	"Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai]
EOG8G7FCB	GO:0005452	1/190	inorganic anion exchanger activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah]
EOG8G7FCB	GO:1902358	1/190	sulfate transmembrane transport	biological_process	"The directed movement of sulfate across a membrane." [GOC:dph, GOC:TermGenie, PMID:9055073]
EOG8G7FCB	GO:0015106	1/190	bicarbonate transmembrane transporter activity	molecular_function	"Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai]
EOG8G7FCB	GO:0008272	1/190	sulfate transport	biological_process	"The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8G7FCB	GO:0019532	1/190	oxalate transport	biological_process	"The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732]
EOG8G7FCB	GO:0015724	1/190	formate transport	biological_process	"The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8G7FCB	GO:0015085	1/190	calcium ion transmembrane transporter activity	molecular_function	"Enables the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:dgf]
EOG8G7FCB	GO:0070588	1/190	calcium ion transmembrane transport	biological_process	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8G7FCB	GO:0015499	1/190	formate transmembrane transporter activity	molecular_function	"Enables the transfer of formate from one side of the membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [GOC:ai]
EOG8G7FCB	GO:0019531	1/190	oxalate transmembrane transporter activity	molecular_function	"Enables the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732]
EOG8G7FCB	GO:0015701	1/190	bicarbonate transport	biological_process	"The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8G7FCH	GO:0016021	12/69	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G7FCH	GO:0004984	11/69	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8G7FCH	GO:0005549	11/69	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8G7FCH	GO:0004930	10/69	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8G7FCH	GO:0005886	6/69	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8G7FCH	GO:0050909	2/69	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8G7FCH	GO:0016020	1/69	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8G7FC6	GO:0008076	33/158	voltage-gated potassium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
EOG8G7FC6	GO:0005249	32/158	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8G7FC6	GO:0006813	1/158	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8G7FC6	GO:0034765	1/158	regulation of ion transmembrane transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
EOG8G7FC6	GO:0005251	1/158	delayed rectifier potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]
EOG8G7FC6	GO:0060048	1/158	cardiac muscle contraction	biological_process	"Muscle contraction of cardiac muscle tissue." [GOC:dph]
EOG8G7FC6	GO:0016021	1/158	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G7FC6	GO:0002027	1/158	regulation of heart rate	biological_process	"Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008]
EOG8G7FC6	GO:0022843	1/158	voltage-gated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8G7FC6	GO:0001700	1/158	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8KD90X	GO:0016787	24/120	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8KD90X	GO:0003824	6/120	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8KD90X	GO:0046872	3/120	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8KD90X	GO:0004725	3/120	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8KD90Z	GO:0005085	23/65	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8KD90Z	GO:0007264	23/65	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8KD90Z	GO:0051056	20/65	regulation of small GTPase mediated signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
EOG8KD90Z	GO:0005952	19/65	cAMP-dependent protein kinase complex	cellular_component	"An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732]
EOG8KD90Z	GO:0008603	19/65	cAMP-dependent protein kinase regulator activity	molecular_function	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]
EOG8KD90Z	GO:0005622	4/65	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8KD90Z	GO:0004691	2/65	cAMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11]
EOG8KD90Z	GO:0004497	1/65	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8KD90Z	GO:0005506	1/65	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8KD90Z	GO:0004692	1/65	cGMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
EOG8KD90Z	GO:0016705	1/65	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8KD90Z	GO:0008270	1/65	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KD90Z	GO:0032487	1/65	regulation of Rap protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Rap protein signal transduction." [GOC:mah]
EOG8KD90Z	GO:0004553	1/65	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8KD90Z	GO:0005975	1/65	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8KD90Z	GO:0020037	1/65	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG87WR2X	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG87WR2X	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG87WR2T	GO:0000775	3/7	chromosome, centromeric region	cellular_component	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
EOG87WR2T	GO:0007067	3/7	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG87WR2T	GO:0005634	3/7	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80P6P9	GO:0005576	3/6	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG80P6P9	GO:0031409	1/6	pigment binding	molecular_function	"Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah]
EOG87WR2K	GO:0005089	1/4	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG80P6P1	GO:0008080	23/93	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG80P6P1	GO:0006909	1/93	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG80P6P3	GO:0006308	1/61	DNA catabolic process	biological_process	"The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732]
EOG80P6P3	GO:0003755	1/61	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG80P6P3	GO:0003723	1/61	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG80P6P3	GO:0035074	1/61	pupation	biological_process	"The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238]
EOG80P6P3	GO:0003677	1/61	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80P6P3	GO:0006457	1/61	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8SJ7V7	GO:0006629	32/50	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8SJ7V7	GO:0005576	31/50	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8SJ7V7	GO:0016787	24/50	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8SJ7V7	GO:0003824	8/50	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8SJ7V7	GO:0032504	1/50	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8SJ7V7	GO:0005615	1/50	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG81ZHSW	GO:0016020	17/90	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8SJ7V8	GO:0005524	40/149	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SJ7V8	GO:0004674	38/149	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8SJ7V8	GO:0004713	2/149	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8SJ7V8	GO:0004672	2/149	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8SJ7V8	GO:0006468	2/149	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8SJ7V8	GO:0004697	1/149	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG8SJ7V8	GO:0007498	1/149	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8C5G0X	GO:0004252	2/5	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8C5G0F	GO:0008293	1/92	torso signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
EOG8C5G0F	GO:0040018	1/92	positive regulation of multicellular organism growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8C5G0F	GO:0008595	1/92	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8C5G0F	GO:0005576	1/92	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8C5G0F	GO:0007362	1/92	terminal region determination	biological_process	"Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8C5G0F	GO:0009880	1/92	embryonic pattern specification	biological_process	"The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
EOG8CZDVP	GO:0008270	1/61	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CZDVP	GO:0004803	1/61	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG8CZDVP	GO:0003700	1/61	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8CZDVP	GO:0005634	1/61	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CZDVP	GO:0006313	1/61	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG8CZDVP	GO:0003677	1/61	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CZDVP	GO:0043565	1/61	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG87WR50	GO:0005634	1/22	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87WR50	GO:0008270	1/22	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XKXPH	GO:0016020	142/797	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XKXPH	GO:0005515	4/797	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8XKXPH	GO:0015031	1/797	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8XKXPH	GO:0046331	1/797	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8XKXPH	GO:0005789	1/797	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8XKXPH	GO:0016021	1/797	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8T4GBH	GO:0004252	2/6	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG866Z1D	GO:0016021	35/124	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG866Z1D	GO:0022857	28/124	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG866Z1D	GO:0022891	7/124	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG866Z1D	GO:0008643	7/124	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG866Z1D	GO:0032440	1/124	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8PRW52	GO:0005089	16/67	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8PRW52	GO:0035556	11/67	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8PRW52	GO:0005524	4/67	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8PRW52	GO:0004674	2/67	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8PRW52	GO:0004713	1/67	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8PRW52	GO:0004672	1/67	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8PRW52	GO:0004683	1/67	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG8XH2DS	GO:0046872	2/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XH2DS	GO:0003676	2/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8PRW54	GO:0003995	85/195	acyl-CoA dehydrogenase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]
EOG8PRW54	GO:0050660	84/195	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8PRW54	GO:0005777	82/195	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8PRW54	GO:0003997	82/195	acyl-CoA oxidase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6]
EOG8PRW54	GO:0006635	81/195	fatty acid beta-oxidation	biological_process	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]
EOG8PRW54	GO:0006629	1/195	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8PRW54	GO:0019395	1/195	fatty acid oxidation	biological_process	"The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732, MetaCyc:FAO-PWY]
EOG8PRW54	GO:0006693	1/195	prostaglandin metabolic process	biological_process	"The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732]
EOG8PRW54	GO:0033540	1/195	fatty acid beta-oxidation using acyl-CoA oxidase	biological_process	"A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5136]
EOG8PRW54	GO:0006091	1/195	generation of precursor metabolites and energy	biological_process	"The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]
EOG8SBHDK	GO:0005215	3/31	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8SBHDK	GO:0008289	3/31	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG8577MX	GO:0016021	75/289	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8577MX	GO:0006486	74/289	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8577MX	GO:0005794	73/289	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8577MX	GO:0046872	72/289	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8577MX	GO:0016757	70/289	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8577MX	GO:0004653	9/289	polypeptide N-acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595]
EOG8577MX	GO:0000139	3/289	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8577MX	GO:0005795	2/289	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG8577MX	GO:0009312	2/289	oligosaccharide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]
EOG8577MX	GO:0006493	1/289	protein O-linked glycosylation	biological_process	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]
EOG8577MX	GO:0033628	1/289	regulation of cell adhesion mediated by integrin	biological_process	"Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add]
EOG8577MX	GO:0070278	1/289	extracellular matrix constituent secretion	biological_process	"The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah]
EOG8577MX	GO:0031589	1/289	cell-substrate adhesion	biological_process	"The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf]
EOG8577MX	GO:0032504	1/289	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8577MX	GO:0008376	1/289	acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]
EOG8577MX	GO:0016266	1/289	O-glycan processing	biological_process	"The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure." [GOC:mah, GOC:pr, PMID:10580130]
EOG88KTRZ	GO:0016021	2/8	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88KTRZ	GO:0022857	2/8	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG88KTRZ	GO:0008643	1/8	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8QRKJ0	GO:0008270	49/217	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8QRKJ0	GO:0016740	1/217	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8PRW5M	GO:0005089	1/26	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8PRW5M	GO:0046872	1/26	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8PRW5M	GO:0035556	1/26	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG88KTRJ	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88KTRJ	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG88KTRJ	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8T4GB7	GO:0006457	29/94	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8T4GB7	GO:0003755	29/94	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8T4GB7	GO:0005634	1/94	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8T4GB7	GO:0000413	1/94	protein peptidyl-prolyl isomerization	biological_process	"The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570]
EOG8T4GB7	GO:0007173	1/94	epidermal growth factor receptor signaling pathway	biological_process	"A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933]
EOG8C5G07	GO:0004252	2199/5565	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8C5G07	GO:0006508	98/5565	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8C5G07	GO:0005615	18/5565	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8C5G07	GO:0005576	17/5565	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8C5G07	GO:0007586	11/5565	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG8C5G07	GO:0004175	8/5565	endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8C5G07	GO:0016021	6/5565	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C5G07	GO:0016787	5/5565	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8C5G07	GO:0016301	5/5565	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8C5G07	GO:0008236	5/5565	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8C5G07	GO:0045087	4/5565	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8C5G07	GO:0006629	4/5565	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8C5G07	GO:0006952	3/5565	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8C5G07	GO:0045752	3/5565	positive regulation of Toll signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8C5G07	GO:0050830	3/5565	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG8C5G07	GO:0008063	3/5565	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8C5G07	GO:0008233	3/5565	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8C5G07	GO:0005829	3/5565	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8C5G07	GO:0008889	3/5565	glycerophosphodiester phosphodiesterase activity	molecular_function	"Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]
EOG8C5G07	GO:0006071	3/5565	glycerol metabolic process	biological_process	"The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]
EOG8C5G07	GO:0050832	3/5565	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8C5G07	GO:0022008	2/5565	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8C5G07	GO:0050829	2/5565	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8C5G07	GO:0009950	2/5565	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8C5G07	GO:0035006	2/5565	melanization defense response	biological_process	"The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809]
EOG8C5G07	GO:0007311	2/5565	maternal specification of dorsal/ventral axis, oocyte, germ-line encoded	biological_process	"Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8C5G07	GO:0031638	2/5565	zymogen activation	biological_process	"The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd]
EOG8C5G07	GO:0008270	1/5565	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8C5G07	GO:0006964	1/5565	positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
EOG8C5G07	GO:0005515	1/5565	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8C5G07	GO:0005622	1/5565	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8C5G07	GO:0004435	1/5565	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8C5G07	GO:0048812	1/5565	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8C5G07	GO:0008592	1/5565	regulation of Toll signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8C5G07	GO:0006967	1/5565	positive regulation of antifungal peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah]
EOG8C5G07	GO:0003964	1/5565	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8C5G07	GO:0035008	1/5565	positive regulation of melanization defense response	biological_process	"Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf]
EOG8C5G07	GO:0035007	1/5565	regulation of melanization defense response	biological_process	"Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf]
EOG8C5G07	GO:0035556	1/5565	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8C5G07	GO:0003723	1/5565	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8C5G07	GO:0005581	1/5565	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8C5G07	GO:0004930	1/5565	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8C5G07	GO:0006909	1/5565	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8C5G07	GO:0004180	1/5565	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8C5G07	GO:0006959	1/5565	humoral immune response	biological_process	"An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]
EOG8C5G07	GO:0004471	1/5565	malate dehydrogenase (decarboxylating) (NAD+) activity	molecular_function	"Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39]
EOG8C5G07	GO:0016485	1/5565	protein processing	biological_process	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]
EOG8C5G07	GO:0003677	1/5565	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8C5G07	GO:0051287	1/5565	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8C5G07	GO:0042060	1/5565	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8SJ7VQ	GO:0016021	23/80	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SJ7VQ	GO:0006810	23/80	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8XKXP4	GO:0003700	1/5	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8XKXP4	GO:0043565	1/5	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8XKXP4	GO:0005634	1/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SJ7VJ	GO:0003676	1/42	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SJ7VJ	GO:0008270	1/42	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KWN6Q	GO:0003676	6/56	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KWN6Q	GO:0008270	5/56	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KWN6Q	GO:0005634	5/56	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8KWN6Q	GO:0046872	1/56	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QNQCQ	GO:0006412	16/53	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8QNQCQ	GO:0003735	16/53	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8QNQCQ	GO:0005840	16/53	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8QNQCQ	GO:0005739	1/53	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8QNQCF	GO:0016021	3/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XWJCW	GO:0016616	2/5	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8XWJCW	GO:0044262	2/5	cellular carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
EOG87M4CQ	GO:0022857	2/4	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG87M4CQ	GO:0016021	2/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JQ6DP	GO:0005524	1/4	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8616JT	GO:0006260	4/30	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8616JT	GO:0005524	4/30	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8616JT	GO:0003677	4/30	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8616JT	GO:0007131	1/30	reciprocal meiotic recombination	biological_process	"The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]
EOG8616JT	GO:0016321	1/30	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8616JT	GO:0007143	1/30	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8616JT	GO:0005737	1/30	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87M4CB	GO:0005737	21/83	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87M4CB	GO:0006434	21/83	seryl-tRNA aminoacylation	biological_process	"The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG87M4CB	GO:0005524	21/83	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87M4CB	GO:0004828	21/83	serine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11]
EOG87M4CB	GO:0005634	3/83	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87M4CB	GO:0008270	3/83	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87M4CB	GO:0003676	2/83	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG87M4CB	GO:0000049	1/83	tRNA binding	molecular_function	"Interacting selectively and non-covalently with transfer RNA." [GOC:ai]
EOG87M4CB	GO:0070584	1/83	mitochondrion morphogenesis	biological_process	"The process in which the anatomical structures of a mitochondrion are generated and organized." [GOC:mah]
EOG87M4CB	GO:0005739	1/83	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG87M4CB	GO:0000166	1/83	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG87M4CB	GO:0045333	1/83	cellular respiration	biological_process	"The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732]
EOG87M4CB	GO:0016874	1/83	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG87M4CK	GO:0008299	12/130	isoprenoid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
EOG87M4CK	GO:0036422	1/130	heptaprenyl diphosphate synthase activity	molecular_function	"Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate." [EC:2.5.1.30, RHEA:27797]
EOG88SK7V	GO:0010923	3/7	negative regulation of phosphatase activity	biological_process	"Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb]
EOG8VMHX3	GO:0005509	2/5	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8VMHX1	GO:0016779	11/50	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG8VMHX1	GO:0046872	5/50	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8VMHX1	GO:0000166	2/50	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8VMHX1	GO:0003676	2/50	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VMHX1	GO:0016740	1/50	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG88SK7K	GO:0004252	20/79	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG88SK7K	GO:0005758	12/79	mitochondrial intermembrane space	cellular_component	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]
EOG88SK7K	GO:0016021	12/79	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88SK7K	GO:0006915	12/79	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG88SK7K	GO:0031966	12/79	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG88SK7K	GO:0008233	3/79	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG88SK7K	GO:0032440	2/79	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG88SK7K	GO:0005515	1/79	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG88SK7K	GO:0007283	1/79	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG88SK7K	GO:0005739	1/79	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG88SK7K	GO:0042981	1/79	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG88SK7K	GO:0035234	1/79	ectopic germ cell programmed cell death	biological_process	"Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944]
EOG88SK7K	GO:0007005	1/79	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG88SK7K	GO:0016006	1/79	Nebenkern	cellular_component	"A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma]
EOG88SK7J	GO:0003887	3/7	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG88SK7J	GO:0003677	3/7	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8W9MMF	GO:0005549	1/5	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG80S2VJ	GO:0016021	21/83	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80S2VJ	GO:0055085	21/83	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG80S2VJ	GO:0005215	3/83	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG80S2VJ	GO:0005886	3/83	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80S2VJ	GO:0008355	1/83	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG80S2VJ	GO:0060179	1/83	male mating behavior	biological_process	"The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb]
EOG80S2VJ	GO:0008021	1/83	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8HB122	GO:0008173	28/72	RNA methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]
EOG8HB122	GO:0008171	28/72	O-methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]
EOG8HB122	GO:0003723	1/72	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8HB122	GO:0046872	1/72	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HB122	GO:0034587	1/72	piRNA metabolic process	biological_process	"The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]
EOG8HB122	GO:0030422	1/72	production of siRNA involved in RNA interference	biological_process	"Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674]
EOG8HB122	GO:0035194	1/72	posttranscriptional gene silencing by RNA	biological_process	"Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation." [GOC:mah, PMID:15020054, PMID:15066275, PMID:15066283]
EOG8HB122	GO:0001510	1/72	RNA methylation	biological_process	"Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd]
EOG8QVFSC	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QVFSC	GO:0005242	2/5	inward rectifier potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398]
EOG8VMHVN	GO:0050660	29/95	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8VMHVN	GO:0045454	28/95	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8VMHVN	GO:0016491	27/95	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8VMHVN	GO:0008860	2/95	ferredoxin-NAD+ reductase activity	molecular_function	"Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+." [EC:1.18.1.3]
EOG8VMHVN	GO:0006915	1/95	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8VMHVN	GO:0042775	1/95	mitochondrial ATP synthesis coupled electron transport	biological_process	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363]
EOG8VMHVN	GO:0010623	1/95	developmental programmed cell death	biological_process	"The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:tb]
EOG8VMHVN	GO:0005758	1/95	mitochondrial intermembrane space	cellular_component	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]
EOG8VMHVN	GO:0050832	1/95	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8VMHVN	GO:0005739	1/95	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG869T9V	GO:0003677	2/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8SBHF6	GO:0004252	1/4	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8SBHF6	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG869T9N	GO:0005549	2/5	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG869T9N	GO:0016020	2/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG869T9N	GO:0004984	2/5	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG869T9D	GO:0003735	2/8	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG869T9D	GO:0005840	2/8	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG869T9D	GO:0006412	2/8	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8DRCW7	GO:0022008	1/74	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8JWXV9	GO:0070552	5/39	BRISC complex	cellular_component	"A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193]
EOG8JWXV9	GO:0045739	5/39	positive regulation of DNA repair	biological_process	"Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators]
EOG8JWXV9	GO:0070531	5/39	BRCA1-A complex	cellular_component	"A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites." [GOC:mah, PMID:19261749]
EOG8TTK0R	GO:0005549	2/6	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG82NMDF	GO:0005524	21/50	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82NMDF	GO:0004713	18/50	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG82NMDF	GO:0016021	3/50	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82NMDF	GO:0004672	2/50	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG82NMDF	GO:0018108	1/50	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG82NMDF	GO:0016772	1/50	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG82NMDF	GO:0006468	1/50	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8K6JJF	GO:0016021	2/7	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8K6JJF	GO:0005524	2/7	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8K6JJF	GO:0004674	1/7	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8K6JJF	GO:0005024	1/7	transforming growth factor beta-activated receptor activity	molecular_function	"Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]
EOG8TTK03	GO:0005549	21/96	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8TTK03	GO:0004984	21/96	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8TTK03	GO:0004930	17/96	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8TTK03	GO:0016021	17/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TTK03	GO:0005886	8/96	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8TTK03	GO:0016020	4/96	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QJV3P	GO:0016772	2/6	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8QJV3Z	GO:0000226	2/7	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8QJV3Z	GO:0005874	2/7	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8QJV3X	GO:0016021	3/7	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z38WS	GO:0031409	1/4	pigment binding	molecular_function	"Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah]
EOG8KH59Q	GO:0004129	45/129	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8KH59Q	GO:0004252	1/129	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8KH59Q	GO:0000278	1/129	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8KH59Q	GO:0005739	1/129	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8KH59Q	GO:0005811	1/129	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8KH59Q	GO:0007030	1/129	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8KH59Q	GO:0008283	1/129	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8SBHFR	GO:0008430	19/51	selenium binding	molecular_function	"Interacting selectively and non-covalently with selenium (Se)." [GOC:ai]
EOG8SBHFR	GO:0045454	19/51	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG886BST	GO:0004252	1/8	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8F20JT	GO:0006412	1/4	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8F20JT	GO:0005840	1/4	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8F20JT	GO:0003735	1/4	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8F20JW	GO:0016021	38/62	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F20JW	GO:0006810	36/62	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8F20JW	GO:0048193	2/62	Golgi vesicle transport	biological_process	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG8F20JW	GO:0005215	2/62	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8F20JW	GO:0005783	1/62	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8F20JW	GO:0000003	1/62	reproduction	biological_process	"The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732]
EOG8F20JW	GO:0061357	1/62	positive regulation of Wnt protein secretion	biological_process	"Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
EOG8F20JW	GO:0090263	1/62	positive regulation of canonical Wnt signaling pathway	biological_process	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]
EOG8F20JW	GO:0048042	1/62	regulation of post-mating oviposition	biological_process	"Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb, PMID:11932766]
EOG8F20JW	GO:0022008	1/62	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8GQSM0	GO:0016021	8/37	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GQSM0	GO:0035556	8/37	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8GQSM0	GO:0000166	6/37	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8GQSM0	GO:0009190	4/37	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG8GQSM0	GO:0004383	4/37	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG8GQSM0	GO:0016849	4/37	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG8GQSM0	GO:0004672	2/37	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8GQSM0	GO:0005524	2/37	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG89626S	GO:0006555	20/85	methionine metabolic process	biological_process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
EOG89626S	GO:0035999	20/85	tetrahydrofolate interconversion	biological_process	"The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999, UniPathway:UPA00193]
EOG89626S	GO:0004489	20/85	methylenetetrahydrofolate reductase (NAD(P)H) activity	molecular_function	"Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20]
EOG8N06X6	GO:0008270	7/79	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KPWQT	GO:0015629	1/6	actin cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
EOG8KPWQT	GO:0030042	1/6	actin filament depolymerization	biological_process	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]
EOG89KJ6P	GO:0008168	1/8	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG89CSR1	GO:0032504	1/68	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG89CSR1	GO:0015918	1/68	sterol transport	biological_process	"The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]
EOG89CSR1	GO:0045456	1/68	ecdysteroid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators]
EOG89CSR1	GO:0005615	1/68	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8HDW9D	GO:0008362	1/102	chitin-based embryonic cuticle biosynthetic process	biological_process	"Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232]
EOG8HDW9D	GO:0045177	1/102	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8HDW9D	GO:0008039	1/102	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8HDW9D	GO:0007475	1/102	apposition of dorsal and ventral imaginal disc-derived wing surfaces	biological_process	"The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu]
EOG8HDW9D	GO:0040005	1/102	chitin-based cuticle attachment to epithelium	biological_process	"Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8DRCSD	GO:0001726	2/7	ruffle	cellular_component	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]
EOG8DRCSD	GO:0005925	2/7	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8DRCSD	GO:0007016	2/7	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG8DRCSD	GO:0005200	2/7	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8DRCSD	GO:0005856	2/7	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG82JR63	GO:0016020	1/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82JR63	GO:0005737	1/5	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82JR63	GO:0007349	1/5	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG8BVV90	GO:0005262	4/8	calcium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8BVV90	GO:0016021	2/8	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BVV90	GO:0016020	2/8	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8DRCSQ	GO:0016021	19/71	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DRCSQ	GO:0005743	19/71	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8DRCSQ	GO:0005509	3/71	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8DRCSQ	GO:0005739	1/71	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8DRCSQ	GO:0022008	1/71	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8DRCSZ	GO:0016787	7/11	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8DRCSX	GO:0016020	20/77	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8DRCSX	GO:0007275	20/77	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8DRCSX	GO:0009966	20/77	regulation of signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]
EOG8DRCSX	GO:0005886	1/77	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8DRCSX	GO:0016318	1/77	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG8DRCSX	GO:0001763	1/77	morphogenesis of a branching structure	biological_process	"The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544]
EOG8DRCSX	GO:0060446	1/77	branching involved in open tracheal system development	biological_process	"The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph]
EOG8DRCSX	GO:0035155	1/77	negative regulation of terminal cell fate specification, open tracheal system	biological_process	"Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [GOC:mtg_sensu, PMID:10684581]
EOG8DRCSX	GO:0009968	1/77	negative regulation of signal transduction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]
EOG8DRCSX	GO:0007426	1/77	tracheal outgrowth, open tracheal system	biological_process	"The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8DRCSX	GO:0007429	1/77	secondary branching, open tracheal system	biological_process	"Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG8DRCSX	GO:0021782	1/77	glial cell development	biological_process	"The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8DRCSX	GO:0005622	1/77	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8DRCSX	GO:0042059	1/77	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8DRCSX	GO:0007424	1/77	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8DRCSX	GO:0048747	1/77	muscle fiber development	biological_process	"The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
EOG8DRCSX	GO:0001745	1/77	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8DRCSX	GO:0046580	1/77	negative regulation of Ras protein signal transduction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
EOG8DRCSX	GO:0030707	1/77	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8DRCSX	GO:0007169	1/77	transmembrane receptor protein tyrosine kinase signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
EOG8DRCSX	GO:0008293	1/77	torso signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
EOG8DRCSX	GO:0040037	1/77	negative regulation of fibroblast growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8DRCSX	GO:0008595	1/77	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8DRCSX	GO:0045314	1/77	regulation of compound eye photoreceptor development	biological_process	"Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
EOG8DRCSX	GO:0007430	1/77	terminal branching, open tracheal system	biological_process	"Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG8CG2RH	GO:0000166	10/38	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8CG2RH	GO:0003899	10/38	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8CG2RH	GO:0006351	10/38	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8BVV9D	GO:0048812	1/64	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8BVV9D	GO:0006974	1/64	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8BVV9D	GO:0043524	1/64	negative regulation of neuron apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
EOG8BVV9D	GO:0042127	1/64	regulation of cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
EOG8STVKC	GO:0005242	2/6	inward rectifier potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398]
EOG8STVKC	GO:0016021	2/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S1WPC	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8S1WPC	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8BVV9R	GO:0005549	6/38	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG86MDZZ	GO:0046872	2/49	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8PK4RD	GO:0016012	30/113	sarcoglycan complex	cellular_component	"A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609]
EOG8PK4RD	GO:0016021	30/113	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PK4RD	GO:0060047	1/113	heart contraction	biological_process	"The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph]
EOG8PK4RD	GO:0043034	1/113	costamere	cellular_component	"Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732, PMID:6405378]
EOG8PK4RD	GO:0045214	1/113	sarcomere organization	biological_process	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
EOG8PK4RD	GO:0007498	1/113	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8PK4RD	GO:0007016	1/113	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG8RZ1FG	GO:0003723	2/10	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RZ1FG	GO:0003964	2/10	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8RZ1FG	GO:0004519	1/10	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8RZ1H0	GO:0003677	5/88	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RZ1H0	GO:0008234	1/88	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8RZ1H0	GO:0003682	1/88	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8RZ1FC	GO:0050909	3/12	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8RZ1FC	GO:0005886	3/12	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8RZ1FC	GO:0016021	3/12	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PK4RN	GO:0000062	2/6	fatty-acyl-CoA binding	molecular_function	"Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732]
EOG8H48KZ	GO:0005549	4/12	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8HTC6H	GO:0051258	47/128	protein polymerization	biological_process	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
EOG8HTC6H	GO:0003924	47/128	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8HTC6H	GO:0005525	47/128	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8HTC6H	GO:0005874	47/128	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8HTC6H	GO:0007020	39/128	microtubule nucleation	biological_process	"The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712]
EOG8HTC6H	GO:0000930	39/128	gamma-tubulin complex	cellular_component	"A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075]
EOG8HTC6H	GO:0031122	39/128	cytoplasmic microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
EOG8HTC6H	GO:0005200	10/128	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8HTC6H	GO:0007017	10/128	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8HTC6H	GO:0005737	9/128	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HTC6H	GO:0007067	2/128	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8HTC6H	GO:0005819	2/128	spindle	cellular_component	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
EOG8HTC6H	GO:0051726	1/128	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8HTC6H	GO:0005813	1/128	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8HTC6H	GO:0051663	1/128	oocyte nucleus localization involved in oocyte dorsal/ventral axis specification	biological_process	"The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte." [GOC:ai, GOC:dph, GOC:mtg_sensu, GOC:tb]
EOG8HTC6H	GO:0000242	1/128	pericentriolar material	cellular_component	"A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]
EOG8HTC6H	GO:0005875	1/128	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8HTC6H	GO:0008275	1/128	gamma-tubulin small complex	cellular_component	"A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075]
EOG8HTC6H	GO:0051316	1/128	attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation	biological_process	"The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex contributing to meiotic chromosome segregation." [GOC:ai, GOC:dph, GOC:tb]
EOG8HTC6H	GO:0007057	1/128	spindle assembly involved in female meiosis I	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah]
EOG8HTC6H	GO:0051297	1/128	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8HTC6H	GO:0051298	1/128	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8HTC6H	GO:0008274	1/128	gamma-tubulin ring complex	cellular_component	"A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule." [GOC:clt, PMID:12134075]
EOG8HTC6H	GO:0010457	1/128	centriole-centriole cohesion	biological_process	"The process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb]
EOG8HTC6H	GO:0019001	1/128	guanyl nucleotide binding	molecular_function	"Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]
EOG8HTC6H	GO:0072687	1/128	meiotic spindle	cellular_component	"A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
EOG8HTC6H	GO:0051306	1/128	mitotic sister chromatid separation	biological_process	"The process in which sister chromatids are physically detached from each other during mitosis." [GOC:ai]
EOG8HTC6H	GO:0007052	1/128	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8HTC6H	GO:0000931	1/128	gamma-tubulin large complex	cellular_component	"A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe." [GOC:mtg_sensu, PMID:12134075]
EOG8N06XJ	GO:0005634	5/36	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8N06XJ	GO:0006355	5/36	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8N06XJ	GO:0016747	5/36	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8HTC6V	GO:0016021	121/277	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HTC6V	GO:0032580	121/277	Golgi cisterna membrane	cellular_component	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]
EOG8HTC6V	GO:0006486	121/277	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8HTC6V	GO:0008417	116/277	fucosyltransferase activity	molecular_function	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
EOG8HTC6V	GO:0017060	3/277	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	molecular_function	"Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.65]
EOG8HTC6V	GO:0018392	3/277	glycoprotein 3-alpha-L-fucosyltransferase activity	molecular_function	"Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H(+)." [EC:2.4.1.214, RHEA:24447]
EOG8HTC6V	GO:0005797	1/277	Golgi medial cisterna	cellular_component	"The middle Golgi cisterna (or cisternae)." [ISBN:0815316194]
EOG8HTC6V	GO:0033932	1/277	1,3-alpha-L-fucosidase activity	molecular_function	"Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins." [EC:3.2.1.111]
EOG8HTC6V	GO:0046920	1/277	alpha-(1->3)-fucosyltransferase activity	molecular_function	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]
EOG8HTC6V	GO:0007399	1/277	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8HTC6V	GO:0036071	1/277	N-glycan fucosylation	biological_process	"The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains." [CHEBI:59520, GOC:sart, PMID:19948734]
EOG8N06XD	GO:0003676	2/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8N06XD	GO:0046872	1/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8N06XD	GO:0008270	1/6	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8N06XD	GO:0005634	1/6	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NZX91	GO:0016301	1/64	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG89S8N7	GO:0046872	2/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NZX90	GO:0000166	1/6	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8NZX90	GO:0003676	1/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82C0Q2	GO:0005634	2/6	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82C0Q2	GO:0006355	2/6	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8FN6XG	GO:0005739	1/41	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8FN6XG	GO:0004129	1/41	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8PCD7C	GO:0005509	9/36	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG88KTSM	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88KTSM	GO:0055085	2/5	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8577NF	GO:0005634	1/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8577NF	GO:0003676	1/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8577NF	GO:0008270	1/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FN6XR	GO:0046872	2/7	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8FN6XR	GO:0003676	2/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88KTSD	GO:0005509	16/68	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG88KTSD	GO:0044719	1/68	regulation of imaginal disc-derived wing size	biological_process	"Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
EOG88KTSD	GO:0016203	1/68	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG88KTSD	GO:0005927	1/68	muscle tendon junction	cellular_component	"A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007]
EOG88KTSD	GO:0008039	1/68	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG80041V	GO:0005634	1/10	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80041V	GO:0043565	1/10	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8HTC87	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HTC87	GO:0003676	1/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG800411	GO:2001020	1/79	regulation of response to DNA damage stimulus	biological_process	"Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
EOG800411	GO:0042048	1/79	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG8DJNCB	GO:0008137	2/81	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8DJNCB	GO:0003954	1/81	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8X99ZD	GO:0005549	3/7	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8X99ZD	GO:0004984	3/7	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8X99ZD	GO:0016020	2/7	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8X99ZD	GO:0004930	1/7	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8X99ZD	GO:0016021	1/7	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X99ZC	GO:0003723	3/23	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8X99ZC	GO:0003964	3/23	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8X99ZC	GO:0003899	3/23	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8X99ZC	GO:0003677	3/23	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X99ZC	GO:0006351	3/23	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8J3ZXQ	GO:0003700	6/27	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8J3ZXQ	GO:0005634	6/27	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8J3ZXQ	GO:0043565	5/27	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8J3ZXQ	GO:0000976	1/27	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG88KTS2	GO:0005506	1/4	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG88KTS2	GO:0020037	1/4	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG88KTS2	GO:0016705	1/4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG84N15X	GO:0005524	4/108	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG84N15X	GO:0017111	3/108	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8X99ZK	GO:0007155	2/5	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8X99ZK	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82C0QN	GO:0016746	5/45	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8TF329	GO:0008270	3/16	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG88SK6X	GO:0005216	1/11	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG88SK6X	GO:0016021	1/11	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DBWX7	GO:0000737	1/76	DNA catabolic process, endonucleolytic	biological_process	"The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
EOG8DBWX7	GO:0003906	1/76	DNA-(apurinic or apyrimidinic site) lyase activity	molecular_function	"Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18]
EOG8DBWX7	GO:0046872	1/76	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DBWX7	GO:0090305	1/76	nucleic acid phosphodiester bond hydrolysis	biological_process	"The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
EOG8DBWX7	GO:0004520	1/76	endodeoxyribonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8DBWX7	GO:0008408	1/76	3'-5' exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]
EOG83XXNH	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZSCHG	GO:0007165	28/104	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8XKXQ7	GO:0004129	43/117	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8XKXQ7	GO:0005740	43/117	mitochondrial envelope	cellular_component	"The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]
EOG8XKXQ7	GO:0005811	1/117	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8BCH44	GO:0003954	1/91	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8BCH44	GO:0008137	1/91	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8QZB10	GO:0005549	4/130	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8QZB10	GO:0016021	4/130	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QZB10	GO:0004984	4/130	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8QZB10	GO:0004930	3/130	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8QZB10	GO:0016020	1/130	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QZB10	GO:0008527	1/130	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8QZB10	GO:0005886	1/130	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8ZSCHS	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZSCHS	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89KJ7B	GO:0004129	35/91	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG89KJ7B	GO:0016887	1/91	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG89KJ7B	GO:0005524	1/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CZDWG	GO:0046872	18/79	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG866Z15	GO:0005615	76/159	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG866Z15	GO:0019239	72/159	deaminase activity	molecular_function	"Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl]
EOG866Z15	GO:0008283	5/159	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG866Z15	GO:0008083	5/159	growth factor activity	molecular_function	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]
EOG866Z15	GO:0004000	5/159	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG866Z15	GO:0046103	5/159	inosine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators]
EOG866Z15	GO:0006154	5/159	adenosine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]
EOG866Z15	GO:0043103	5/159	hypoxanthine salvage	biological_process	"Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis." [GOC:jl, ISBN:0198506732]
EOG866Z15	GO:0016021	1/159	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG866Z15	GO:0042386	1/159	hemocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723]
EOG866Z15	GO:0016020	1/159	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG866Z15	GO:0006109	1/159	regulation of carbohydrate metabolic process	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators]
EOG866Z15	GO:0043617	1/159	cellular response to sucrose starvation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose." [GOC:jl]
EOG866Z15	GO:0007286	1/159	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG8QZB1M	GO:0004767	5/118	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8QZB1M	GO:0016787	4/118	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG80S2W1	GO:0016021	18/35	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80S2W1	GO:0055085	18/35	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG80S2W1	GO:0005886	4/35	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80S2W1	GO:0005215	4/35	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8VDSF4	GO:0035162	1/80	embryonic hemopoiesis	biological_process	"The stages of blood cell formation that take place within the embryo." [GOC:bf]
EOG8VDSF4	GO:0005769	1/80	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG8VDSF4	GO:0046425	1/80	regulation of JAK-STAT cascade	biological_process	"Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf]
EOG8VDSF4	GO:0005764	1/80	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8VDSF4	GO:0016021	1/80	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VDSF4	GO:0055037	1/80	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG8VDSF4	GO:0048542	1/80	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG8VDSF4	GO:0035167	1/80	larval lymph gland hemopoiesis	biological_process	"The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385]
EOG8VDSF4	GO:0005794	1/80	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8VDSF4	GO:0031410	1/80	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG8B2WD3	GO:0003824	1/4	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8B2WD3	GO:0004252	1/4	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8M0HJ0	GO:0005549	3/58	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG85MQMK	GO:0071011	1/107	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG85MQMK	GO:0071013	1/107	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG85MQMK	GO:0000398	1/107	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG81RS98	GO:0003700	21/82	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG81RS98	GO:0043565	21/82	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG81RS98	GO:0005634	19/82	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81RS98	GO:0046983	1/82	protein dimerization activity	molecular_function	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]
EOG81RS98	GO:0005515	1/82	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG81RS98	GO:0055088	1/82	lipid homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]
EOG81RS98	GO:0006955	1/82	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG81RS98	GO:0007399	1/82	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG85MQMZ	GO:0016787	1/4	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8616K8	GO:0016021	29/137	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8616K8	GO:0055085	28/137	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8616K8	GO:0015293	1/137	symporter activity	molecular_function	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
EOG8616K8	GO:0006816	1/137	calcium ion transport	biological_process	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8616K8	GO:0008273	1/137	calcium, potassium:sodium antiporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1]
EOG8616K8	GO:0035725	1/137	sodium ion transmembrane transport	biological_process	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
EOG8616K8	GO:0006814	1/137	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8616K8	GO:0048749	1/137	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8616K8	GO:0048812	1/137	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8NGK3S	GO:0003964	2/58	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8NGK3S	GO:0003723	1/58	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG84XMXM	GO:0003676	5/112	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84XMXM	GO:0005515	2/112	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG84XMXM	GO:0007049	1/112	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG84XMXM	GO:0006351	1/112	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG84XMXM	GO:0003677	1/112	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84XMXM	GO:0031523	1/112	Myb complex	cellular_component	"A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624]
EOG84XMXM	GO:0005700	1/112	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG84XMXM	GO:0030317	1/112	sperm motility	biological_process	"Any process involved in the controlled movement of a sperm cell." [GOC:jl]
EOG84XMXM	GO:0000790	1/112	nuclear chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130]
EOG84XMXM	GO:0007307	1/112	eggshell chorion gene amplification	biological_process	"Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771]
EOG84XMXM	GO:0000122	1/112	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG84XMXM	GO:0005634	1/112	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84XMXM	GO:0051039	1/112	positive regulation of transcription during meiosis	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription during meiosis." [GOC:ai]
EOG84XMXM	GO:0008340	1/112	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG84XMXM	GO:0048477	1/112	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG84XMXM	GO:0007140	1/112	male meiosis	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
EOG84XMXM	GO:0000785	1/112	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG84BDH8	GO:0003676	1/3	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84BDH8	GO:0046872	1/3	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84BDH7	GO:0004022	74/125	alcohol dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
EOG84BDH7	GO:0006066	22/125	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG84BDH7	GO:0016491	17/125	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG84BDH7	GO:0046164	4/125	alcohol catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, GOC:ai]
EOG84BDH7	GO:0045735	2/125	nutrient reservoir activity	molecular_function	"Functions in the storage of nutritious substrates." [GOC:ai]
EOG84BDH7	GO:0005811	2/125	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG84BDH7	GO:0048149	1/125	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG84BDH7	GO:0005829	1/125	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG84BDH7	GO:0042572	1/125	retinol metabolic process	biological_process	"The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]
EOG84BDH7	GO:0042574	1/125	retinal metabolic process	biological_process	"The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [CHEBI:15035, GOC:curators, ISBN:0198506732]
EOG84BDH7	GO:0048812	1/125	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG84BDH7	GO:0004745	1/125	retinol dehydrogenase activity	molecular_function	"Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [EC:1.1.1.105]
EOG84BDH7	GO:0042803	1/125	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG84BDH7	GO:0016404	1/125	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	molecular_function	"Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141]
EOG84BDH7	GO:0005875	1/125	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG84BDH7	GO:0006909	1/125	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG84BDH7	GO:0043234	1/125	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG841SSX	GO:0009055	1/59	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG841SSX	GO:0051536	1/59	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8QNQB6	GO:0004185	2/6	serine-type carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG841SSV	GO:0016020	1/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG841SSV	GO:0005549	1/5	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG841SSV	GO:0004984	1/5	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8QNQB4	GO:0030246	2/14	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG81NX1M	GO:0008270	22/81	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81NX1M	GO:0009056	22/81	catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]
EOG81NX1M	GO:0016788	14/81	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG80GG6M	GO:0016020	1/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG80GG6M	GO:0005549	1/5	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG80GG6M	GO:0004984	1/5	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8F4VTS	GO:0005576	5/31	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8F4VTS	GO:0007218	2/31	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8T1M2X	GO:0003700	22/68	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8T1M2X	GO:0043565	22/68	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8T1M2X	GO:0042803	1/68	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8DJN9C	GO:0016620	23/92	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG8DJN9C	GO:0016742	23/92	hydroxymethyl-, formyl- and related transferase activity	molecular_function	"Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2, GOC:mah]
EOG8DJN9C	GO:0009058	23/92	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG8DJN9C	GO:0008168	19/92	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8DJN9C	GO:0016155	14/92	formyltetrahydrofolate dehydrogenase activity	molecular_function	"Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH." [EC:1.5.1.6, RHEA:10183]
EOG8DJN9C	GO:0009258	13/92	10-formyltetrahydrofolate catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai]
EOG8DJN9C	GO:0005737	13/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8DJN9C	GO:0006730	13/92	one-carbon metabolic process	biological_process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
EOG841SS0	GO:0016021	1/76	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG841SS0	GO:0004721	1/76	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8QNQBK	GO:0016021	1/53	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QNQBK	GO:0055085	1/53	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8QNQBK	GO:0005576	1/53	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8QNQBK	GO:0007339	1/53	binding of sperm to zona pellucida	biological_process	"The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437]
EOG81NX19	GO:0004743	2/4	pyruvate kinase activity	molecular_function	"Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40]
EOG81NX19	GO:0000287	2/4	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG81NX19	GO:0030955	2/4	potassium ion binding	molecular_function	"Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah]
EOG81NX19	GO:0006096	2/4	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG83N9VW	GO:0005634	95/339	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83N9VW	GO:0003700	95/339	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG83N9VW	GO:0043565	89/339	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG83N9VW	GO:0019101	1/339	female somatic sex determination	biological_process	"The determination of sex and sexual phenotypes in a female organism's soma." [GOC:mah]
EOG83N9VW	GO:0000398	1/339	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG83N9VW	GO:0003677	1/339	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG83N9VW	GO:0007548	1/339	sex differentiation	biological_process	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]
EOG83N9VW	GO:0045497	1/339	female analia development	biological_process	"The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
EOG83N9VW	GO:0001078	1/339	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
EOG83N9VW	GO:0008049	1/339	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG83N9VW	GO:0045892	1/339	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0046661	1/339	male sex differentiation	biological_process	"The establishment of the sex of a male organism by physical differentiation." [GOC:bf]
EOG83N9VW	GO:0048086	1/339	negative regulation of developmental pigmentation	biological_process	"Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
EOG83N9VW	GO:0045433	1/339	male courtship behavior, veined wing generated song production	biological_process	"The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
EOG83N9VW	GO:0018993	1/339	somatic sex determination	biological_process	"The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems]
EOG83N9VW	GO:0006355	1/339	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0042803	1/339	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG83N9VW	GO:0045893	1/339	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0048071	1/339	sex-specific pigmentation	biological_process	"Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jid]
EOG83N9VW	GO:0045496	1/339	male analia development	biological_process	"The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
EOG83N9VW	GO:0007619	1/339	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG83N9VW	GO:0007283	1/339	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG83N9VW	GO:0007417	1/339	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG83N9VW	GO:0016199	1/339	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG83N9VW	GO:0035215	1/339	genital disc development	biological_process	"Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318]
EOG83N9VW	GO:0045944	1/339	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0046872	1/339	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83N9VW	GO:0003729	1/339	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG83N9VW	GO:0045498	1/339	sex comb development	biological_process	"The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk]
EOG83N9VW	GO:0005515	1/339	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG83N9VW	GO:0000122	1/339	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0007483	1/339	genital disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238]
EOG83N9VW	GO:0001077	1/339	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG83N9VW	GO:0007530	1/339	sex determination	biological_process	"Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732]
EOG83N9VW	GO:0007486	1/339	imaginal disc-derived female genitalia development	biological_process	"The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
EOG83N9VW	GO:0006357	1/339	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0019102	1/339	male somatic sex determination	biological_process	"The determination of sex and sexual phenotypes in a male organism's soma." [GOC:mah]
EOG83N9VW	GO:0007485	1/339	imaginal disc-derived male genitalia development	biological_process	"The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
EOG83N9VW	GO:0035263	1/339	genital disc sexually dimorphic development	biological_process	"The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781]
EOG83N9VW	GO:0046660	1/339	female sex differentiation	biological_process	"The establishment of the sex of a female organism by physical differentiation." [GOC:bf]
EOG83N9VW	GO:0045570	1/339	regulation of imaginal disc growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators]
EOG8NGK35	GO:0016021	25/93	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NGK35	GO:0043065	25/93	positive regulation of apoptotic process	biological_process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8NGK35	GO:0005740	24/93	mitochondrial envelope	cellular_component	"The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]
EOG8NGK35	GO:0097345	1/93	mitochondrial outer membrane permeabilization	biological_process	"The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:pg, PMID:21041309]
EOG8NGK35	GO:0005741	1/93	mitochondrial outer membrane	cellular_component	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
EOG8NGK35	GO:0043067	1/93	regulation of programmed cell death	biological_process	"Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
EOG84BDHV	GO:0016021	2/31	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83N9VD	GO:0008270	1/15	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8HMMT0	GO:0008076	53/210	voltage-gated potassium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
EOG8HMMT0	GO:0005249	52/210	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8HMMT0	GO:0051260	48/210	protein homooligomerization	biological_process	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
EOG8HMMT0	GO:0005251	2/210	delayed rectifier potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]
EOG8HMMT0	GO:0004114	2/210	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular_function	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]
EOG8HMMT0	GO:0030431	1/210	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8HMMT0	GO:0046872	1/210	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HMMT0	GO:0006813	1/210	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8HMMT0	GO:0005886	1/210	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8642SZ	GO:0046872	2/7	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8642SZ	GO:0003676	2/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HQGZV	GO:0005089	1/4	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8BVV8B	GO:0016021	2/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BVV8B	GO:0008643	1/6	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8BVV8B	GO:0022891	1/6	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8BVV8B	GO:0022857	1/6	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8BVV8C	GO:0055085	2/5	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8BVV8C	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82JR5W	GO:0070526	22/93	tRNA threonylcarbamoyladenosine modification	biological_process	"The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base)." [GO:0070526, GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706]
EOG82JR5W	GO:0016747	19/93	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG82JR5W	GO:0046872	19/93	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82JR5W	GO:0005739	19/93	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG82JR5W	GO:0004222	16/93	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG82JR5W	GO:0016787	1/93	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8JHFX5	GO:0006412	39/111	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8JHFX5	GO:0003735	37/111	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8JHFX5	GO:0015935	37/111	small ribosomal subunit	cellular_component	"The smaller of the two subunits of a ribosome." [GOC:mah]
EOG8JHFX5	GO:0003723	36/111	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8JHFX5	GO:0005840	2/111	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8JHFX5	GO:0005737	1/111	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8JHFX5	GO:0005875	1/111	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8JHFX5	GO:0007052	1/111	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8JHFX5	GO:0000022	1/111	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8JHFX5	GO:0022008	1/111	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8JHFX5	GO:0005730	1/111	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8JHFX5	GO:0000228	1/111	nuclear chromosome	cellular_component	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
EOG8642SW	GO:0005975	33/55	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8642SW	GO:0016810	32/55	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
EOG8642SW	GO:0003824	1/55	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8RZ1GP	GO:0031110	2/5	regulation of microtubule polymerization or depolymerization	biological_process	"Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]
EOG8642ST	GO:0005634	2/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8642ST	GO:0004842	2/4	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8642ST	GO:0006511	2/4	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8642ST	GO:0007275	2/4	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8642ST	GO:0008270	2/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8642SN	GO:0004672	1/5	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG87SVXP	GO:0042302	1/3	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG87SVXQ	GO:0006412	22/69	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG87SVXQ	GO:0005840	4/69	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG87SVXQ	GO:0003735	2/69	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG87SVXQ	GO:0005739	2/69	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG87SVXQ	GO:0005762	1/69	mitochondrial large ribosomal subunit	cellular_component	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
EOG8323FR	GO:0003677	7/32	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG808QPR	GO:0007165	23/117	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG808QPR	GO:0005622	20/117	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG808QPR	GO:0005096	20/117	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG808QPR	GO:0005737	3/117	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG808QPR	GO:0003964	3/117	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG808QPR	GO:0007229	1/117	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG808QPR	GO:0003723	1/117	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG808QPR	GO:0035058	1/117	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG808QPR	GO:0034464	1/117	BBSome	cellular_component	"A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [GOC:BHF, PMID:17574030]
EOG8H48JP	GO:0005524	1/4	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8H48JP	GO:0008026	1/4	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8H48JP	GO:0003723	1/4	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8HTC7M	GO:0008080	1/6	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG8HTC7T	GO:0006275	26/107	regulation of DNA replication	biological_process	"Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]
EOG8HTC7T	GO:0007348	1/107	regulation of syncytial blastoderm mitotic cell cycle	biological_process	"A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8HTC7T	GO:0007307	1/107	eggshell chorion gene amplification	biological_process	"Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771]
EOG8HTC7T	GO:0007113	1/107	endomitotic cell cycle	biological_process	"A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm]
EOG8HTC7T	GO:0005634	1/107	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HTC7T	GO:0042059	1/107	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8HTC7T	GO:0008156	1/107	negative regulation of DNA replication	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators]
EOG8GQSN1	GO:0016567	25/74	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8GQSN1	GO:0005634	25/74	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GQSN1	GO:0090307	1/74	mitotic spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis." [GOC:tb, GOC:vw]
EOG8GQSN1	GO:1900037	1/74	regulation of cellular response to hypoxia	biological_process	"Any process that modulates the frequency, rate or extent of cellular response to hypoxia." [GOC:TermGenie, GOC:yaf]
EOG8GQSN1	GO:0030891	1/74	VCB complex	cellular_component	"A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1." [GOC:mah, PMID:11865071]
EOG8GQSN1	GO:0005515	1/74	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8GQSN1	GO:0035556	1/74	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8GQSN1	GO:0030154	1/74	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8GQSN1	GO:0007427	1/74	epithelial cell migration, open tracheal system	biological_process	"The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8GQSN1	GO:0016334	1/74	establishment or maintenance of polarity of follicular epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah]
EOG8GQSN1	GO:0007026	1/74	negative regulation of microtubule depolymerization	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]
EOG8GQSN1	GO:0007424	1/74	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8GQSN1	GO:0001525	1/74	angiogenesis	biological_process	"Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453]
EOG8GQSN1	GO:0006611	1/74	protein export from nucleus	biological_process	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]
EOG8GQSN1	GO:0060438	1/74	trachea development	biological_process	"The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG8GQSN1	GO:0035149	1/74	lumen formation, open tracheal system	biological_process	"Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
EOG8GQSN1	GO:0051297	1/74	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8MWBKW	GO:0005634	30/107	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8MWBKW	GO:0008270	29/107	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MWBKW	GO:0003677	26/107	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8MWBKW	GO:0016706	24/107	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG8MWBKW	GO:0034720	1/107	histone H3-K4 demethylation	biological_process	"The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone." [GOC:mah]
EOG8MWBKW	GO:0007275	1/107	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8MWBKW	GO:0034721	1/107	histone H3-K4 demethylation, trimethyl-H3-K4-specific	biological_process	"The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone." [GOC:mah]
EOG8MWBKW	GO:0006325	1/107	chromatin organization	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
EOG8MWBKW	GO:0043992	1/107	histone acetyltransferase activity (H3-K9 specific)	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48]
EOG8MWBKW	GO:0043970	1/107	histone H3-K9 acetylation	biological_process	"The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl]
EOG8MWBKW	GO:0045893	1/107	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8MWBKW	GO:0006351	1/107	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8MWBKW	GO:0034647	1/107	histone demethylase activity (H3-trimethyl-K4 specific)	molecular_function	"Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896]
EOG8MWBKW	GO:0032453	1/107	histone demethylase activity (H3-K4 specific)	molecular_function	"Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein." [GOC:mah]
EOG8MWBKW	GO:0045475	1/107	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8MWBKW	GO:0070822	1/107	Sin3-type complex	cellular_component	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]
EOG8MWBKW	GO:0005515	1/107	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8MWBKW	GO:0016577	1/107	histone demethylation	biological_process	"The modification of histones by removal of methyl groups." [GOC:ai]
EOG8VMHW2	GO:0016787	19/74	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8KH582	GO:0035556	19/57	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8NGK2N	GO:0004252	12/110	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8NGK2N	GO:0020037	1/110	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8NGK2N	GO:0016705	1/110	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8NGK2N	GO:0005506	1/110	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8KH58R	GO:0004725	18/82	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8KH58R	GO:0050254	2/82	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8KH58R	GO:0005777	1/82	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8VMHWQ	GO:0003676	2/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VMHWQ	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8VMHWQ	GO:0008270	1/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VMHWQ	GO:0005634	1/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82VBXP	GO:0005634	15/23	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82VBXP	GO:0043565	14/23	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG82VBXP	GO:0003700	14/23	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG82VBXP	GO:0008354	1/23	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG82VBXP	GO:0035050	1/23	embryonic heart tube development	biological_process	"The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
EOG82VBXP	GO:0045944	1/23	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG82VBXP	GO:0061101	1/23	neuroendocrine cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance." [GOC:dph]
EOG82VBXP	GO:0007507	1/23	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG82VBXP	GO:0010002	1/23	cardioblast differentiation	biological_process	"The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG82VBXP	GO:0008406	1/23	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG82VBXP	GO:0007435	1/23	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG82VBXP	GO:0003677	1/23	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG82VBXP	GO:0007501	1/23	mesodermal cell fate specification	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
EOG82VBXP	GO:0045893	1/23	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82VBXP	GO:0007506	1/23	gonadal mesoderm development	biological_process	"The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai]
EOG82VBXP	GO:0007280	1/23	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG82VBXP	GO:0007552	1/23	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG82VBXP	GO:0006366	1/23	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG82VBXP	GO:0003705	1/23	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG82VBXP	GO:0035051	1/23	cardiocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf]
EOG82VBXP	GO:0071907	1/23	determination of digestive tract left/right asymmetry	biological_process	"Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:cvs]
EOG82VBXP	GO:0007510	1/23	cardioblast cell fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG82VBXP	GO:0000980	1/23	RNA polymerase II distal enhancer sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH]
EOG82VBXP	GO:0001708	1/23	cell fate specification	biological_process	"The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators]
EOG82VBXP	GO:0048615	1/23	embryonic anterior midgut (ectodermal) morphogenesis	biological_process	"The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc]
EOG82VBXP	GO:0055007	1/23	cardiac muscle cell differentiation	biological_process	"The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:devbiol, GOC:mtg_heart]
EOG82VBXP	GO:0061320	1/23	pericardial nephrocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]
EOG82VBXP	GO:0048542	1/23	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG82VBXP	GO:0007498	1/23	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG82VBXP	GO:0045892	1/23	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82VBXQ	GO:0003676	11/57	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82VBXQ	GO:0008270	11/57	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG82VBXQ	GO:0000166	10/57	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG82JR59	GO:0005524	1/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82JR59	GO:0004672	1/5	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8RFP85	GO:0016021	4/25	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82VBXZ	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8642S4	GO:0003824	64/235	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8642S4	GO:0047747	4/235	cholate-CoA ligase activity	molecular_function	"Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA." [EC:6.2.1.7, MetaCyc:CHOLATE--COA-LIGASE-RXN]
EOG8642S4	GO:0016874	1/235	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8642S4	GO:0005886	1/235	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8642S4	GO:0015909	1/235	long-chain fatty acid transport	biological_process	"The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ai]
EOG8642S4	GO:0070328	1/235	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG8642S4	GO:0005324	1/235	long-chain fatty acid transporter activity	molecular_function	"Enables the directed movement of long-chain fatty acids into, out of or within a cell, or between cells. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, ISBN:0198506732]
EOG87SVX7	GO:0005549	9/26	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG82VBXF	GO:0006955	5/96	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG82VBXF	GO:0005044	5/96	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG82VBXF	GO:0030247	5/96	polysaccharide binding	molecular_function	"Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah]
EOG82VBXF	GO:0004064	1/96	arylesterase activity	molecular_function	"Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2]
EOG82VBXG	GO:0043565	2/5	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG82VBXG	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8K3PCG	GO:0005272	1/5	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8K3PCG	GO:0016020	1/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG808QP3	GO:0007165	6/22	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG808QP3	GO:0006511	3/22	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG808QP3	GO:0007275	3/22	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG808QP3	GO:0008270	3/22	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG808QP3	GO:0005634	3/22	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG808QP3	GO:0004842	3/22	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG808QP3	GO:0016021	2/22	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG808QP3	GO:0006955	1/22	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG808QP3	GO:0004888	1/22	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG808QP3	GO:0002224	1/22	toll-like receptor signaling pathway	biological_process	"Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
EOG88GZH5	GO:0016021	33/129	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88GZH5	GO:0004930	32/129	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG88GZH5	GO:0005886	28/129	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG88GZH5	GO:0008343	1/129	adult feeding behavior	biological_process	"Feeding behavior in a fully developed and mature organism." [GOC:mah]
EOG88GZH5	GO:0003676	1/129	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88GZH5	GO:0030425	1/129	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG88GZH5	GO:0005887	1/129	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88GZH5	GO:0007200	1/129	phospholipase C-activating G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
EOG88GZH5	GO:0017085	1/129	response to insecticide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]
EOG88GZH5	GO:0051966	1/129	regulation of synaptic transmission, glutamatergic	biological_process	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
EOG8DNHKX	GO:0008745	2/3	N-acetylmuramoyl-L-alanine amidase activity	molecular_function	"Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]
EOG8DNHKX	GO:0009253	2/3	peptidoglycan catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
EOG8DNHKX	GO:0008270	1/3	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8JQ6F4	GO:0007186	1/58	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8JQ6F4	GO:0005615	1/58	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8JQ6F4	GO:0001664	1/58	G-protein coupled receptor binding	molecular_function	"Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph]
EOG8X3KK5	GO:0031225	1/4	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG8X3KK5	GO:0008237	1/4	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8X3KK5	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8X3KK5	GO:0016805	1/4	dipeptidase activity	molecular_function	"Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com]
EOG8R7XT3	GO:0006396	2/5	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8R7XT3	GO:0004000	2/5	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8R7XT3	GO:0003723	2/5	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG84N16F	GO:0005578	21/86	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG84N16F	GO:0005886	21/86	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG84N16F	GO:0031225	21/86	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG84N16F	GO:0007480	1/86	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG84N16F	GO:0007409	1/86	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG84N16F	GO:0008407	1/86	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG84N16F	GO:0007476	1/86	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG84N16F	GO:0035220	1/86	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG84N16F	GO:0030513	1/86	positive regulation of BMP signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators]
EOG84N16F	GO:0009986	1/86	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG84N16F	GO:0030718	1/86	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG84N16F	GO:0008101	1/86	decapentaplegic signaling pathway	biological_process	"A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:sart, PMID:17428827]
EOG84N16F	GO:0048190	1/86	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG84N16F	GO:0008045	1/86	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG84N16F	GO:0008586	1/86	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG84N16F	GO:0048749	1/86	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG84N16F	GO:0040014	1/86	regulation of multicellular organism growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG84N16F	GO:2001261	1/86	negative regulation of semaphorin-plexin signaling pathway	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of semaphorin-plexin signaling pathway." [GOC:BHF]
EOG84N16F	GO:0030510	1/86	regulation of BMP signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah]
EOG84N16F	GO:0051726	1/86	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG84N16F	GO:0007472	1/86	wing disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG84N16F	GO:0045570	1/86	regulation of imaginal disc growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators]
EOG84N16F	GO:0048813	1/86	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG84N16F	GO:0005515	1/86	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG84N16F	GO:0022416	1/86	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG84N16F	GO:0048132	1/86	female germ-line stem cell asymmetric division	biological_process	"The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu]
EOG84N16F	GO:0016055	1/86	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG84N16F	GO:0008052	1/86	sensory organ boundary specification	biological_process	"The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained." [GO_REF:0000021, GOC:mtg_15jun06]
EOG8MSGDQ	GO:0003676	3/26	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MSGDQ	GO:0046872	3/26	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8SN448	GO:0005215	1/8	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8SN448	GO:0005622	1/8	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG82C0R8	GO:0008168	24/85	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG82C0R8	GO:0018016	1/85	N-terminal peptidyl-proline dimethylation	biological_process	"The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline." [RESID:AA0066]
EOG82C0R8	GO:0016571	1/85	histone methylation	biological_process	"The modification of histones by addition of methyl groups." [GOC:ai]
EOG82C0R8	GO:0035568	1/85	N-terminal peptidyl-proline methylation	biological_process	"The methylation of the N-terminal proline of proteins." [PMID:20668449, RESID:AA0419]
EOG82C0R8	GO:0000179	1/85	rRNA (adenine-N6,N6-)-dimethyltransferase activity	molecular_function	"Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410]
EOG82C0R8	GO:0005634	1/85	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82C0R8	GO:0071885	1/85	N-terminal protein N-methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser." [PMID:20481588]
EOG82C0R8	GO:0042054	1/85	histone methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue." [EC:2.1.1.43]
EOG8CNT86	GO:0016829	1/45	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8CNT86	GO:0046872	1/45	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CNT86	GO:0030170	1/45	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8CNT86	GO:0004252	1/45	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8CNT86	GO:0006520	1/45	cellular amino acid metabolic process	biological_process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]
EOG8DJNB7	GO:0016021	44/181	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DJNB7	GO:0005230	39/181	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8DJNB7	GO:0005886	38/181	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8DJNB7	GO:0030054	36/181	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8DJNB7	GO:0045202	35/181	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8DJNB7	GO:0004890	23/181	GABA-A receptor activity	molecular_function	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333]
EOG8DJNB7	GO:0006811	5/181	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8DJNB7	GO:0006812	1/181	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8DJNB7	GO:0005254	1/181	chloride channel activity	molecular_function	"Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8DJNB7	GO:0007165	1/181	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8DJNB7	GO:0015276	1/181	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8DJNB7	GO:0016933	1/181	extracellular-glycine-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8DJNB7	GO:0034707	1/181	chloride channel complex	cellular_component	"An ion channel complex through which chloride ions pass." [GOC:mah]
EOG8DJNB7	GO:0005261	1/181	cation channel activity	molecular_function	"Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8DJNB7	GO:0034220	1/181	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8DJNB7	GO:0045211	1/181	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8JQ6FX	GO:0030414	1/4	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8CNT6N	GO:0005215	3/21	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8CNT6N	GO:0008021	3/21	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8CNT6N	GO:0016020	3/21	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG851H6B	GO:0004252	1/5	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG88WFJB	GO:0003677	1/10	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG85MQNG	GO:0016301	8/464	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG85MQNG	GO:0005576	3/464	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG85MQNG	GO:0004672	1/464	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG85MQNG	GO:0045297	1/464	post-mating behavior	biological_process	"The specific behavior of an organism following mating." [GOC:bf, GOC:pr]
EOG85MQNG	GO:0006468	1/464	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG85MQNG	GO:0004674	1/464	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG85B3X0	GO:0008270	1/9	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG85B3X0	GO:0006730	1/9	one-carbon metabolic process	biological_process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
EOG85B3X0	GO:0004089	1/9	carbonate dehydratase activity	molecular_function	"Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1]
EOG8TF330	GO:0005549	2/6	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8TF330	GO:0016020	2/6	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8TF330	GO:0004984	2/6	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG837TWH	GO:0006633	21/66	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG837TWH	GO:0070469	1/66	respiratory chain	cellular_component	"The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684]
EOG837TWH	GO:0031177	1/66	phosphopantetheine binding	molecular_function	"Interacting selectively and non-covalently with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah, GOC:vw]
EOG837TWH	GO:0005739	1/66	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG837TWH	GO:0006120	1/66	mitochondrial electron transport, NADH to ubiquinone	biological_process	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363]
EOG837TWH	GO:0000036	1/66	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process	molecular_function	"Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis." [CHEBI:22221, GOC:jl, GOC:vw]
EOG8W3W2J	GO:0000166	28/119	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8W3W2J	GO:0003676	27/119	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W3W2J	GO:0003729	1/119	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8KSRZK	GO:0005524	11/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KSRZK	GO:0004674	9/91	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8KSRZK	GO:0004687	1/91	myosin light chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18]
EOG8KSRZK	GO:0004672	1/91	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8W3W26	GO:0046872	7/50	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8W3W26	GO:0003676	6/50	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W3W26	GO:0003677	1/50	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8W3W28	GO:0016020	2/4	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8W3W28	GO:0008237	2/4	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8W3W28	GO:0008241	2/4	peptidyl-dipeptidase activity	molecular_function	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]
EOG8THZ7G	GO:0008812	1/5	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG8THZ7G	GO:0050660	1/5	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8THZ7G	GO:0006066	1/5	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG85MQN0	GO:0003964	1/38	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG85MQN0	GO:0046872	1/38	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85B3XN	GO:0005576	2/5	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8JWXX2	GO:0006950	2/5	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG80040K	GO:0008137	2/5	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG80040K	GO:0009579	1/5	thylakoid	cellular_component	"A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732]
EOG8S1WNT	GO:0016021	13/53	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S1WNT	GO:0005230	7/53	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8S1WNT	GO:0030054	6/53	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8S1WNT	GO:0045211	6/53	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8S1WNT	GO:0004889	6/53	acetylcholine-activated cation-selective channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]
EOG834ZMZ	GO:0016491	2/7	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG84BDGB	GO:0006281	54/171	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG84BDGB	GO:0003913	50/171	DNA photolyase activity	molecular_function	"Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949]
EOG84BDGB	GO:0009882	5/171	blue light photoreceptor activity	molecular_function	"The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb]
EOG84BDGB	GO:0005634	5/171	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84BDGB	GO:0045892	5/171	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG84BDGB	GO:0009785	5/171	blue light signaling pathway	biological_process	"The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm." [GOC:lr, GOC:sm]
EOG84BDGB	GO:0018298	5/171	protein-chromophore linkage	biological_process	"The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma]
EOG84BDGB	GO:0048471	5/171	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG84BDGB	GO:0005737	5/171	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84BDGB	GO:0006351	5/171	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG84BDGB	GO:0000060	5/171	protein import into nucleus, translocation	biological_process	"A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope." [GOC:curators, ISBN:0198506732, PMID:14570049, PMID:9126736]
EOG84BDGB	GO:0050660	5/171	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG84BDGB	GO:0042752	5/171	regulation of circadian rhythm	biological_process	"Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]
EOG84BDGB	GO:0005641	5/171	nuclear envelope lumen	cellular_component	"The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide." [GOC:ai]
EOG84BDGB	GO:0048511	4/171	rhythmic process	biological_process	"Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid]
EOG84BDGB	GO:0003904	2/171	deoxyribodipyrimidine photo-lyase activity	molecular_function	"Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light." [EC:4.1.99.3]
EOG84BDGB	GO:0043234	1/171	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG84BDGB	GO:0045475	1/171	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG84BDGB	GO:0050980	1/171	detection of light stimulus involved in magnetoreception	biological_process	"The series of events involved in magnetoception in which a light stimulus is received and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field." [GOC:ai, GOC:dos, PMID:15886990, Wikipedia:Magnetoception]
EOG84BDGB	GO:0007602	1/171	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG84BDGB	GO:0043153	1/171	entrainment of circadian clock by photoperiod	biological_process	"The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl]
EOG84BDGB	GO:0009416	1/171	response to light stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
EOG84BDGB	GO:0009637	1/171	response to blue light	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:ai, GOC:mtg_far_red]
EOG84BDGB	GO:0007623	1/171	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG84BDGB	GO:0005515	1/171	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG84BDGB	GO:0009649	1/171	entrainment of circadian clock	biological_process	"The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid]
EOG84BDGB	GO:0003914	1/171	DNA (6-4) photolyase activity	molecular_function	"Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA." [GOC:mah, PMID:11124949]
EOG84BDGB	GO:0071949	1/171	FAD binding	molecular_function	"Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]
EOG84BDGB	GO:0050958	1/171	magnetoreception	biological_process	"The series of events required for an organism to receive a stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Stimuli may be chemical, mechanical or electrical and interpreting these stimuli allows an organism to determine the orientation of a magnetic field. Magnetoreception also involves the perception of light; birds cannot orient without the presence of short wavelength (blue/green) light." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]
EOG84BDGB	GO:0009881	1/171	photoreceptor activity	molecular_function	"The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators]
EOG84BDGB	GO:0042332	1/171	gravitaxis	biological_process	"The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
EOG84BDGB	GO:0071000	1/171	response to magnetism	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:sl]
EOG8FBM8Z	GO:0005634	70/166	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FBM8Z	GO:0003682	3/166	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8FBM8Z	GO:0005515	2/166	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FBM8Z	GO:0008270	2/166	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FBM8Z	GO:0006355	2/166	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8FBM8Z	GO:0006351	2/166	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8FBM8Z	GO:0000792	2/166	heterochromatin	cellular_component	"A compact and highly condensed form of chromatin." [GOC:elh]
EOG8FBM8Z	GO:0031940	1/166	positive regulation of chromatin silencing at telomere	biological_process	"Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah]
EOG8FBM8Z	GO:0000122	1/166	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8FBM8Z	GO:0006342	1/166	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG8FBM8Z	GO:0042981	1/166	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8FBM8Z	GO:0006357	1/166	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8FBM8Z	GO:0005654	1/166	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG8FBM8Z	GO:0005694	1/166	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8FBM8Z	GO:0042393	1/166	histone binding	molecular_function	"Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl]
EOG8FBM8Z	GO:0045893	1/166	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8FBM8Z	GO:0005700	1/166	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8FBM8Z	GO:0016568	1/166	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG8FBM8Z	GO:0003729	1/166	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8FBM8Z	GO:0035064	1/166	methylated histone binding	molecular_function	"Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf, PMID:14585615]
EOG8FBM8Z	GO:0005703	1/166	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG8FBM8Z	GO:0022008	1/166	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8FBM8Z	GO:0035012	1/166	polytene chromosome, telomeric region	cellular_component	"The terminal region of a polytene chromosome." [GOC:bf]
EOG8FBM8Z	GO:0005705	1/166	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG8FBM8Z	GO:0045944	1/166	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8FBM8Z	GO:0031060	1/166	regulation of histone methylation	biological_process	"Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]
EOG8FBM8Z	GO:1900111	1/166	positive regulation of histone H3-K9 dimethylation	biological_process	"Any process that activates or increases the frequency, rate or extent of histone H3-K9 dimethylation." [GOC:TermGenie, GOC:vw]
EOG8FBM8Z	GO:0005701	1/166	polytene chromosome chromocenter	cellular_component	"A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012]
EOG8FBM8Z	GO:0000182	1/166	rDNA binding	molecular_function	"Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA." [GOC:mah]
EOG8FBM8Z	GO:0045892	1/166	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8FBM8Z	GO:0031452	1/166	negative regulation of heterochromatin assembly	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation." [GOC:mah]
EOG8FBM8Z	GO:0043234	1/166	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8FBM8Z	GO:0006343	1/166	establishment of chromatin silencing	biological_process	"The initial formation of a transcriptionally silent chromatin structure such as heterochromatin." [GOC:mah]
EOG8FBM8Z	GO:0003696	1/166	satellite DNA binding	molecular_function	"Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005]
EOG8FBM8Z	GO:0033697	1/166	positive regulation of extent of heterochromatin assembly	biological_process	"Any process that increases the extent of heterochromatin formation; increases the size of a chromosomal region converted to heterochromatin." [GOC:mah]
EOG8FBM8Z	GO:0034773	1/166	histone H4-K20 trimethylation	biological_process	"The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone." [GOC:mah]
EOG8FBM8Z	GO:0000780	1/166	condensed nuclear chromosome, centromeric region	cellular_component	"The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
EOG8FBM8Z	GO:0016458	1/166	gene silencing	biological_process	"Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb]
EOG8FBM8Z	GO:0030702	1/166	chromatin silencing at centromere	biological_process	"Repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:mah]
EOG8FBM8Z	GO:0005704	1/166	polytene chromosome band	cellular_component	"A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342]
EOG8FBM8Z	GO:0005720	1/166	nuclear heterochromatin	cellular_component	"A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732]
EOG8FBM8Z	GO:0051276	1/166	chromosome organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8FBM8Z	GO:0003677	1/166	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FBM8Z	GO:0000723	1/166	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8FBM8Z	GO:0000781	1/166	chromosome, telomeric region	cellular_component	"The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh]
EOG8FBM8Z	GO:0031507	1/166	heterochromatin assembly	biological_process	"The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent." [GOC:mah]
EOG8FBM8Z	GO:0000793	1/166	condensed chromosome	cellular_component	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]
EOG8FBM8Z	GO:0044026	1/166	DNA hypermethylation	biological_process	"An increase in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/]
EOG8FBM8Z	GO:0005721	1/166	pericentric heterochromatin	cellular_component	"Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [PMID:12019236, PMID:20206496, PMID:22729156]
EOG8FBM8Z	GO:0003676	1/166	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FBM8Z	GO:0000775	1/166	chromosome, centromeric region	cellular_component	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
EOG8FBM8Z	GO:0000791	1/166	euchromatin	cellular_component	"A dispersed and relatively uncompacted form of chromatin." [GOC:elh]
EOG8JDKNZ	GO:0005576	5/9	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8MKQXG	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8JDKNK	GO:0008484	1/3	sulfuric ester hydrolase activity	molecular_function	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]
EOG8NCPTB	GO:0016746	24/265	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8NCPTB	GO:0000502	4/265	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG8NCPTB	GO:0016021	2/265	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NCPTB	GO:0005838	1/265	proteasome regulatory particle	cellular_component	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]
EOG8NCPTB	GO:0006508	1/265	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8NCPTB	GO:0008541	1/265	proteasome regulatory particle, lid subcomplex	cellular_component	"The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb]
EOG8NCPTB	GO:0003735	1/265	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8NCPTB	GO:0005875	1/265	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8NCPTB	GO:0006412	1/265	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8NCPTB	GO:0005840	1/265	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8NCPTB	GO:0043161	1/265	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG8MKQX9	GO:0004383	2/4	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG8MKQX9	GO:0035556	2/4	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8WM7BG	GO:0007165	2/23	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8Z91CS	GO:0004129	1/4	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8MKQX5	GO:0005506	3/6	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8MKQX5	GO:0020037	3/6	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8MKQX5	GO:0016705	3/6	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8MKQX5	GO:0004497	1/6	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG86HJQF	GO:0007018	38/185	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG86HJQF	GO:0003777	38/185	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG86HJQF	GO:0005524	34/185	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG86HJQF	GO:0016887	32/185	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG86HJQF	GO:0030286	29/185	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG86HJQF	GO:0042623	2/185	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG86HJQF	GO:0016539	2/185	intein-mediated protein splicing	biological_process	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]
EOG86HJQF	GO:0006200	2/185	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG86HJQF	GO:0006355	1/185	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG86HJQF	GO:0005858	1/185	axonemal dynein complex	cellular_component	"A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. May contain two or three dynein heavy chains as well as several light chains." [ISBN:0815316194]
EOG86HJQF	GO:0007605	1/185	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG86HJQF	GO:0005634	1/185	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86HJQF	GO:0005875	1/185	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG84BDG2	GO:0035091	22/99	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG84BDG2	GO:0003824	20/99	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG84BDG2	GO:0070290	3/99	N-acylphosphatidylethanolamine-specific phospholipase D activity	molecular_function	"Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE)." [GOC:elh, PMID:14634025, PMID:15878693]
EOG84BDG2	GO:0004630	3/99	phospholipase D activity	molecular_function	"Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4]
EOG84BDG2	GO:0032440	2/99	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG84BDG2	GO:0007030	1/99	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG84BDG2	GO:0031410	1/99	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG84BDG2	GO:0007349	1/99	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG84BDG2	GO:0048215	1/99	positive regulation of Golgi vesicle fusion to target membrane	biological_process	"Any process that activates or increases the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG84BDG2	GO:0010004	1/99	gastrulation involving germ band extension	biological_process	"A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG84BDG2	GO:0007602	1/99	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG84BDG9	GO:0006869	4/29	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG84BDG9	GO:0008270	1/29	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84BDG9	GO:0004222	1/29	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG86HJQR	GO:0046872	2/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8D55BZ	GO:0035091	10/54	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG8D55BZ	GO:0038032	10/54	termination of G-protein coupled receptor signaling pathway	biological_process	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]
EOG8D55BZ	GO:0043565	1/54	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8D55BZ	GO:0003700	1/54	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8R52HV	GO:0016491	2/7	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8S1WN7	GO:0042773	2/5	ATP synthesis coupled electron transport	biological_process	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363]
EOG8S1WN7	GO:0016020	2/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8S1WN7	GO:0008137	2/5	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8S1WN7	GO:0009055	2/5	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8S1WN7	GO:0051536	2/5	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8K0T29	GO:0008138	22/109	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG8K0T29	GO:0004725	21/109	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8K0T29	GO:0016314	3/109	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	molecular_function	"Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67]
EOG8K0T29	GO:0007155	1/109	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8K0T29	GO:0035206	1/109	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8K0T29	GO:0035069	1/109	larval midgut histolysis	biological_process	"The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683]
EOG8K0T29	GO:0009888	1/109	tissue development	biological_process	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]
EOG8K0T29	GO:0030308	1/109	negative regulation of cell growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8K0T29	GO:0016322	1/109	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG8K0T29	GO:0002164	1/109	larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088]
EOG8K0T29	GO:0007436	1/109	larval salivary gland morphogenesis	biological_process	"The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8K0T29	GO:0045792	1/109	negative regulation of cell size	biological_process	"Any process that reduces cell size." [GOC:go_curators]
EOG8K0T29	GO:0003779	1/109	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8K0T29	GO:0008361	1/109	regulation of cell size	biological_process	"Any process that modulates the size of a cell." [GOC:go_curators]
EOG8K0T29	GO:0030036	1/109	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8K0T29	GO:0031104	1/109	dendrite regeneration	biological_process	"The regrowth of dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb]
EOG8K0T29	GO:0006470	1/109	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8K0T29	GO:0035011	1/109	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG8K0T29	GO:0009987	1/109	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8K0T29	GO:0004726	1/109	non-membrane spanning protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8K0T29	GO:0046620	1/109	regulation of organ growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
EOG8K0T29	GO:0004721	1/109	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8K0T29	GO:0035335	1/109	peptidyl-tyrosine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
EOG8K0T29	GO:0045786	1/109	negative regulation of cell cycle	biological_process	"Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8K0T29	GO:0046621	1/109	negative regulation of organ growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
EOG8K0T29	GO:0007425	1/109	epithelial cell fate determination, open tracheal system	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940]
EOG8K0T29	GO:0034613	1/109	cellular protein localization	biological_process	"Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]
EOG8K0T29	GO:0042052	1/109	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8K0T29	GO:0040015	1/109	negative regulation of multicellular organism growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG8K0T29	GO:0048681	1/109	negative regulation of axon regeneration	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
EOG8K0T29	GO:0046856	1/109	phosphatidylinositol dephosphorylation	biological_process	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]
EOG8K0T29	GO:0010506	1/109	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8K0T29	GO:0008283	1/109	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8K0T29	GO:0006629	1/109	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8K0T29	GO:0046627	1/109	negative regulation of insulin receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8K0T29	GO:0009887	1/109	organ morphogenesis	biological_process	"Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]
EOG8K0T29	GO:0019915	1/109	lipid storage	biological_process	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]
EOG8K0T29	GO:0016491	1/109	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8K0T29	GO:0005216	1/109	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8K0T29	GO:0050773	1/109	regulation of dendrite development	biological_process	"Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai]
EOG8K0T29	GO:0090175	1/109	regulation of establishment of planar polarity	biological_process	"Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8K0T29	GO:0008360	1/109	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8K0T29	GO:0006914	1/109	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG8K0T29	GO:0007010	1/109	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8K0T29	GO:0042594	1/109	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8K0T29	GO:0016021	1/109	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8K0T29	GO:1901888	1/109	regulation of cell junction assembly	biological_process	"Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]
EOG8K0T29	GO:0007552	1/109	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG8K0T29	GO:0006915	1/109	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8K0T29	GO:0040014	1/109	regulation of multicellular organism growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG8K0T29	GO:0008286	1/109	insulin receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]
EOG8K0T29	GO:0045926	1/109	negative regulation of growth	biological_process	"Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
EOG8K0T29	GO:0007015	1/109	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8K0T29	GO:0004722	1/109	protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
EOG80S2XJ	GO:0003682	1/4	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG80S2XJ	GO:0006281	1/4	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG80S2XJ	GO:0051382	1/4	kinetochore assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]
EOG8SBHD4	GO:0005622	26/77	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8SBHD4	GO:0005215	26/77	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8TTJZ2	GO:0007155	28/115	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8TTJZ2	GO:0015629	28/115	actin cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
EOG8TTJZ2	GO:0005198	28/115	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8TTJZ2	GO:0003779	1/115	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8TTJZ2	GO:0048812	1/115	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8TTJZ2	GO:0005925	1/115	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8TTJZ2	GO:0006909	1/115	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8TTJZ2	GO:0005737	1/115	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8TTJZ2	GO:0007016	1/115	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG8TTJZ2	GO:0005886	1/115	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG883GK8	GO:0000145	2/6	exocyst	cellular_component	"A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152]
EOG883GK8	GO:0006904	2/6	vesicle docking involved in exocytosis	biological_process	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]
EOG883GK8	GO:0015031	2/6	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG883GK4	GO:0036257	1/96	multivesicular body organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [GOC:sart, PMID:11566881]
EOG883GK4	GO:0007472	1/96	wing disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG883GK4	GO:0016197	1/96	endosomal transport	biological_process	"The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]
EOG883GK4	GO:0045732	1/96	positive regulation of protein catabolic process	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]
EOG883GK4	GO:0048749	1/96	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG883GK4	GO:0005737	1/96	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG883GK4	GO:0008586	1/96	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG883GK4	GO:0007219	1/96	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG883GK4	GO:0045746	1/96	negative regulation of Notch signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG883GK4	GO:0030100	1/96	regulation of endocytosis	biological_process	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]
EOG883GK4	GO:0007423	1/96	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG883GK4	GO:0045035	1/96	sensory organ precursor cell division	biological_process	"The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597]
EOG883GK4	GO:0008593	1/96	regulation of Notch signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG883GK4	GO:0006886	1/96	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG883GK4	GO:0016324	1/96	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG883GK4	GO:0005543	1/96	phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8CRPFM	GO:0016021	17/50	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CRPFM	GO:0007155	17/50	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8CRPFM	GO:0050896	2/50	response to stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
EOG8CRPFM	GO:0007608	2/50	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8CRPFM	GO:0005886	2/50	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8M3CQ1	GO:0008236	43/96	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8M3CQ1	GO:0004180	1/96	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8HMMSG	GO:0071254	1/193	cytoplasmic U snRNP body	cellular_component	"A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295]
EOG8HMMSG	GO:0035363	1/193	histone locus body	cellular_component	"A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body." [GOC:sart, PMID:16533947, PMID:18927579, PMID:19620235]
EOG8HMMSG	GO:0000381	1/193	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8HMMSG	GO:0005634	1/193	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HMMSG	GO:0005515	1/193	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8HMMSG	GO:0071204	1/193	histone pre-mRNA 3'end processing complex	cellular_component	"A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1." [GOC:mah, PMID:19470752]
EOG8HMMSG	GO:0016021	1/193	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HMMSG	GO:0016192	1/193	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8HMMSG	GO:0006398	1/193	histone mRNA 3'-end processing	biological_process	"Any process involved in forming the mature 3' end of a histone mRNA molecule." [GOC:mah]
EOG8HMMSG	GO:0016604	1/193	nuclear body	cellular_component	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]
EOG8V9X7Q	GO:0008270	1/8	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V9X7Q	GO:0005634	1/8	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HMMSJ	GO:0000723	4/40	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8HMMSJ	GO:0003678	4/40	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8HMMSJ	GO:0006281	4/40	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8HMMSJ	GO:0030414	1/40	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8HMMSJ	GO:0016706	1/40	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG8HMMSJ	GO:0005576	1/40	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8NGK2B	GO:0016021	2/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NGK2B	GO:0055085	1/6	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8NGK2B	GO:0022857	1/6	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8K3PB4	GO:0003677	26/41	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8K3PB4	GO:0007416	1/41	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG8K3PB4	GO:0005634	1/41	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8K3PB4	GO:0045893	1/41	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8K3PB4	GO:0048813	1/41	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8K3PB4	GO:0008345	1/41	larval locomotory behavior	biological_process	"Locomotory behavior in a larval (immature) organism." [GOC:ai]
EOG8K3PB4	GO:0007616	1/41	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8K3PB4	GO:0001077	1/41	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG8K3PB4	GO:0008355	1/41	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8K3PB4	GO:0007611	1/41	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG8K3PB4	GO:0050773	1/41	regulation of dendrite development	biological_process	"Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai]
EOG8K3PB4	GO:0045944	1/41	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8K3PB4	GO:0007613	1/41	memory	biological_process	"The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089]
EOG8K3PB4	GO:0005705	1/41	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG8K3PB4	GO:0040011	1/41	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG8K3PB3	GO:0000776	6/45	kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG8K3PB3	GO:0034508	6/45	centromere complex assembly	biological_process	"The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw]
EOG8K3PB3	GO:0016773	1/45	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8M3CQQ	GO:0004252	2/6	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8V9X72	GO:0008270	41/538	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V9X72	GO:0003676	38/538	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V9X72	GO:0003964	3/538	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8V9X72	GO:0003723	3/538	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8V9X72	GO:0006811	1/538	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8V9X72	GO:0005921	1/538	gap junction	cellular_component	"A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181]
EOG8NGK2S	GO:0051537	2/5	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8NGK2S	GO:0009055	2/5	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8NGK2S	GO:0006099	2/5	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8NGK2S	GO:0016491	2/5	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8V9X79	GO:0007218	1/4	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG841SRR	GO:0016021	10/159	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG841SRR	GO:0022857	9/159	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG841SRR	GO:0003677	2/159	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG841SRR	GO:0000278	1/159	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG841SRR	GO:0016905	1/159	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG841SRR	GO:0042023	1/159	DNA endoreduplication	biological_process	"Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw]
EOG841SRR	GO:0005215	1/159	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG841SRR	GO:0055085	1/159	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG841SRR	GO:0035185	1/159	preblastoderm mitotic cell cycle	biological_process	"The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238]
EOG8TQPPR	GO:0005319	25/103	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG8TQPPR	GO:0007016	1/103	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG8TQPPR	GO:0030139	1/103	endocytic vesicle	cellular_component	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]
EOG8TQPPR	GO:0005102	1/103	receptor binding	molecular_function	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]
EOG8TQPPR	GO:0046872	1/103	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TQPPR	GO:0020037	1/103	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8TQPPR	GO:0005504	1/103	fatty acid binding	molecular_function	"Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732]
EOG8TQPPR	GO:0005615	1/103	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8TQPPR	GO:0001726	1/103	ruffle	cellular_component	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]
EOG8TQPPR	GO:0005576	1/103	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8TQPPR	GO:0006869	1/103	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG8TQPPR	GO:0007224	1/103	smoothened signaling pathway	biological_process	"A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
EOG8TQPPR	GO:0005200	1/103	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8TQPPR	GO:0016192	1/103	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8TQPPR	GO:0007155	1/103	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8TQPPR	GO:0005811	1/103	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8TQPPR	GO:0045178	1/103	basal part of cell	cellular_component	"The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194]
EOG8TQPPR	GO:0006810	1/103	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8TQPPR	GO:0015629	1/103	actin cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
EOG8TQPPR	GO:0019841	1/103	retinol binding	molecular_function	"Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation." [CHEBI:50211, GOC:curators]
EOG8TQPPR	GO:0008017	1/103	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8TQPPR	GO:0005925	1/103	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8TQPPR	GO:0005875	1/103	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8TQPPR	GO:0016055	1/103	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG8TQPPR	GO:0016020	1/103	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HX7DX	GO:0016849	4/10	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG8HX7DX	GO:0009190	4/10	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG8HX7DX	GO:0035556	4/10	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8HX7DX	GO:0016787	1/10	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG81NX2S	GO:0016773	3/8	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG81NX2S	GO:0016301	1/8	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8SBHDT	GO:0004252	2/6	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG841SRD	GO:0005524	40/149	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG841SRD	GO:0007169	27/149	transmembrane receptor protein tyrosine kinase signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
EOG841SRD	GO:0004714	27/149	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG841SRD	GO:0016021	20/149	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG841SRD	GO:0004713	12/149	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG841SRD	GO:0016020	9/149	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG841SRD	GO:0004672	1/149	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG841SRD	GO:0018108	1/149	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG841SRD	GO:0004930	1/149	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG841SRD	GO:0007417	1/149	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG841SRD	GO:0006468	1/149	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG841SRD	GO:0016787	1/149	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG841SRD	GO:0004715	1/149	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8SBHDF	GO:0016021	26/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SBHDF	GO:0004930	26/99	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8SBHDF	GO:0050254	2/99	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8SBHDF	GO:0097004	1/99	adipokinetic hormone binding	molecular_function	"Interacting selectively and non-covalently with an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407]
EOG8SBHDF	GO:0097003	1/99	adipokinetic hormone receptor activity	molecular_function	"Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407]
EOG8SBHDF	GO:0005887	1/99	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SBHDF	GO:0007218	1/99	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8SBHDF	GO:0006117	1/99	acetaldehyde metabolic process	biological_process	"The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [CHEBI:15343, GOC:go_curators]
EOG8SBHDF	GO:0048149	1/99	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8SBHDF	GO:0071361	1/99	cellular response to ethanol	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:mah]
EOG8SBHDF	GO:0035237	1/99	corazonin receptor activity	molecular_function	"Combining with the neuropeptide corazonin to initiate a change in cell activity." [GOC:bf]
EOG8SBHDF	GO:0008188	1/99	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8SBHDF	GO:0007186	1/99	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG81NX2G	GO:0016491	2/4	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8SBHDB	GO:0003676	2/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SBHDB	GO:0046872	2/7	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8SBHDB	GO:0008270	1/7	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SBHDB	GO:0005634	1/7	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RBT0C	GO:0005634	9/34	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RBT0C	GO:0003700	9/34	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8RBT0C	GO:0043565	5/34	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8RBT0C	GO:0007275	5/34	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8RBT0C	GO:0000976	4/34	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8RBT0C	GO:0004000	1/34	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8RBT0G	GO:0009072	27/84	aromatic amino acid family metabolic process	biological_process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]
EOG8RBT0G	GO:0003868	27/84	4-hydroxyphenylpyruvate dioxygenase activity	molecular_function	"Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27]
EOG8RBT0G	GO:0046872	22/84	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RBT0G	GO:0004462	1/84	lactoylglutathione lyase activity	molecular_function	"Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19072]
EOG880M9M	GO:0043087	27/102	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG880M9M	GO:0007269	1/102	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG880M9M	GO:0030234	1/102	enzyme regulator activity	molecular_function	"Binds to and modulates the activity of an enzyme." [GOC:mah]
EOG880M9M	GO:0008021	1/102	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG880M9M	GO:0046982	1/102	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG880M9M	GO:0016192	1/102	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG880M9M	GO:0007298	1/102	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG880M9M	GO:0005096	1/102	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG80VZ3H	GO:0003682	2/6	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG80VZ3H	GO:0016021	1/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80VZ3H	GO:0030054	1/6	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG80VZ3H	GO:0005886	1/6	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80VZ3H	GO:0045202	1/6	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG80VZ3H	GO:0005230	1/6	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG81RS89	GO:0055085	250/817	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG81RS89	GO:0005215	250/817	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG81RS89	GO:0016021	249/817	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81RS89	GO:0016020	2/817	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG81RS89	GO:0006814	1/817	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG81RS89	GO:0051780	1/817	behavioral response to nutrient	biological_process	"Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus." [GOC:ai]
EOG81RS89	GO:0008343	1/817	adult feeding behavior	biological_process	"Feeding behavior in a fully developed and mature organism." [GOC:mah]
EOG81RS89	GO:0016323	1/817	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG81RS89	GO:0015293	1/817	symporter activity	molecular_function	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
EOG81RS89	GO:0007156	1/817	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG81RS89	GO:0005509	1/817	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8ZW7RD	GO:0003924	2/11	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8ZW7RD	GO:0005874	2/11	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8ZW7RD	GO:0005525	2/11	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8ZW7RD	GO:0051258	2/11	protein polymerization	biological_process	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
EOG8ZW7RD	GO:0005200	2/11	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8ZW7RD	GO:0007017	2/11	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8ZW7RD	GO:0005737	1/11	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZW7RF	GO:0007155	21/105	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8ZW7RF	GO:0016020	20/105	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8ZW7RF	GO:0016021	3/105	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZW7RF	GO:0016319	1/105	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8ZW7RF	GO:0005515	1/105	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8ZW7RF	GO:0048667	1/105	cell morphogenesis involved in neuron differentiation	biological_process	"The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb]
EOG8ZW7RF	GO:0072553	1/105	terminal button organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:BHF, GOC:mah]
EOG8ZW7RF	GO:0050803	1/105	regulation of synapse structure or activity	biological_process	"Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]
EOG8ZW7RF	GO:0005886	1/105	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8ZW7RF	GO:0048786	1/105	presynaptic active zone	cellular_component	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
EOG8ZW7RF	GO:0007612	1/105	learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544]
EOG8ZW7RF	GO:0031225	1/105	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG8ZW7RF	GO:0042995	1/105	cell projection	cellular_component	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
EOG8ZW7RF	GO:0030424	1/105	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8ZW7RF	GO:0050808	1/105	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG8ZW7RF	GO:0007614	1/105	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8ZW7RF	GO:0001746	1/105	Bolwig's organ morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380]
EOG8ZW7RF	GO:0007156	1/105	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8ZW7RF	GO:0008582	1/105	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8ZW7RF	GO:0007413	1/105	axonal fasciculation	biological_process	"The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh]
EOG8ZW7RF	GO:0045211	1/105	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8ZW7RF	GO:0035159	1/105	regulation of tube length, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
EOG8ZW7RF	GO:0007611	1/105	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG8ZW7RF	GO:0042059	1/105	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8ZW7RF	GO:0035152	1/105	regulation of tube architecture, open tracheal system	biological_process	"Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584]
EOG8ZW7RF	GO:0008355	1/105	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8ZW7RF	GO:0061174	1/105	type I terminal bouton	cellular_component	"Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc]
EOG8ZW7RF	GO:0097482	1/105	muscle cell postsynaptic density	cellular_component	"A postsynaptic density that is part of a muscle cell." [GOC:pr]
EOG8ZW7RF	GO:0007528	1/105	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8ZW7RF	GO:0072499	1/105	photoreceptor cell axon guidance	biological_process	"The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
EOG8ZW7RF	GO:0008038	1/105	neuron recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators]
EOG8ZW7RF	GO:0031594	1/105	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8ZW7RF	GO:0035158	1/105	regulation of tube diameter, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584]
EOG8ZW7RF	GO:0036062	1/105	presynaptic periactive zone	cellular_component	"A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development." [GOC:sart, PMID:10976048, PMID:18439406]
EOG8ZW7RF	GO:0005737	1/105	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZW7RF	GO:0048803	1/105	imaginal disc-derived male genitalia morphogenesis	biological_process	"The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu]
EOG8ZW7RF	GO:0048149	1/105	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8ZW7RF	GO:0042734	1/105	presynaptic membrane	cellular_component	"A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194]
EOG8ZW7RF	GO:0008360	1/105	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG808QQ3	GO:0006099	28/94	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG808QQ3	GO:0004149	28/94	dihydrolipoyllysine-residue succinyltransferase activity	molecular_function	"Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61]
EOG808QQ3	GO:0045252	28/94	oxoglutarate dehydrogenase complex	cellular_component	"A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [MetaCyc:CPLX66-42, PMID:10848975]
EOG808QQ3	GO:0005811	1/94	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG808QQ3	GO:0004742	1/94	dihydrolipoyllysine-residue acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12]
EOG808QQ3	GO:0016746	1/94	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG808QQ3	GO:0005875	1/94	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8ZW7RX	GO:0016021	44/122	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZW7RX	GO:0006810	39/122	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8ZW7RX	GO:0055085	4/122	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8ZW7RX	GO:0006310	2/122	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8ZW7RX	GO:0015074	2/122	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8ZW7RX	GO:0003677	2/122	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8ZW7RX	GO:0035435	1/122	phosphate ion transmembrane transport	biological_process	"The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
EOG8ZW7RX	GO:0015114	1/122	phosphate ion transmembrane transporter activity	molecular_function	"Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai]
EOG8ZW7RX	GO:0005811	1/122	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8ZW7RX	GO:0048190	1/122	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8ZW7RX	GO:0006817	1/122	phosphate ion transport	biological_process	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8ZW7RX	GO:0005743	1/122	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG808QQ5	GO:0035556	1/6	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG808QQ7	GO:0004185	2/4	serine-type carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8RZ1DR	GO:0016021	64/210	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RZ1DR	GO:0004930	63/210	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8RZ1DR	GO:0007218	4/210	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8RZ1DR	GO:0007186	3/210	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8RZ1DR	GO:0008188	3/210	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8RZ1DR	GO:0007193	2/210	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
EOG8RZ1DR	GO:0008344	2/210	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG8RZ1DR	GO:0035013	2/210	myosuppressin receptor activity	molecular_function	"Combining with the peptide myosuppressin to initiate a change in cell activity." [GOC:bf]
EOG8RZ1DR	GO:0005887	2/210	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RZ1DR	GO:0002209	1/210	behavioral defense response	biological_process	"A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8RZ1DR	GO:0008345	1/210	larval locomotory behavior	biological_process	"Locomotory behavior in a larval (immature) organism." [GOC:ai]
EOG8RZ1DQ	GO:0016491	10/35	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8PK4PS	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PK4PS	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PK4PS	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG86Q98C	GO:0016740	2/54	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG86Q98C	GO:0005634	1/54	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86Q98C	GO:0006351	1/54	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG86Q98C	GO:0003677	1/54	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86Q98C	GO:0005737	1/54	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86Q98C	GO:0006355	1/54	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG86Q98C	GO:0046887	1/54	positive regulation of hormone secretion	biological_process	"Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai]
EOG86Q98C	GO:0045944	1/54	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG86Q98C	GO:0030154	1/54	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG86Q98C	GO:0007275	1/54	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG86Q98C	GO:0002793	1/54	positive regulation of peptide secretion	biological_process	"Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add]
EOG8642RQ	GO:0004525	29/109	ribonuclease III activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]
EOG8642RQ	GO:0003723	28/109	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8642RQ	GO:0006396	28/109	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8642RQ	GO:0004386	26/109	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8642RQ	GO:0005524	26/109	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8642RQ	GO:0003676	3/109	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8642RQ	GO:0016891	2/109	endoribonuclease activity, producing 5'-phosphomonoesters	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
EOG8642RQ	GO:0070883	1/109	pre-miRNA binding	molecular_function	"Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA." [PMID:18951094]
EOG8642RQ	GO:0003727	1/109	single-stranded RNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl]
EOG8642RQ	GO:0007367	1/109	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG8642RQ	GO:0016443	1/109	bidentate ribonuclease III activity	molecular_function	"Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference." [PMID:15242644]
EOG8642RQ	GO:0042078	1/109	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG8642RQ	GO:0003725	1/109	double-stranded RNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]
EOG8642RQ	GO:0045448	1/109	mitotic cell cycle, embryonic	biological_process	"The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators]
EOG8642RQ	GO:0046872	1/109	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8642RQ	GO:0031054	1/109	pre-miRNA processing	biological_process	"Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]
EOG8642RQ	GO:0016246	1/109	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG8642RQ	GO:0030727	1/109	germarium-derived female germ-line cyst formation	biological_process	"Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902]
EOG8642RQ	GO:0033227	1/109	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8642RQ	GO:0007294	1/109	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8642RQ	GO:0005737	1/109	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8642RQ	GO:0090501	1/109	RNA phosphodiester bond hydrolysis	biological_process	"The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
EOG8642RQ	GO:0030422	1/109	production of siRNA involved in RNA interference	biological_process	"Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674]
EOG8642RQ	GO:0035087	1/109	siRNA loading onto RISC involved in RNA interference	biological_process	"The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference." [GOC:bf, GOC:mah, PMID:14512631]
EOG8642RQ	GO:0035196	1/109	production of miRNAs involved in gene silencing by miRNA	biological_process	"Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein." [GOC:dph, GOC:tb, PMID:15066275, PMID:15066283]
EOG8642RQ	GO:0090502	1/109	RNA phosphodiester bond hydrolysis, endonucleolytic	biological_process	"The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
EOG8642RQ	GO:0007279	1/109	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8642RQ	GO:0016442	1/109	RISC complex	cellular_component	"A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]
EOG8642RQ	GO:0005515	1/109	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8642RQ	GO:0048813	1/109	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG81RS8J	GO:0046872	5/40	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81RS8J	GO:0003676	5/40	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG86Q98Q	GO:0006030	2/6	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG86Q98Q	GO:0008061	2/6	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG86Q98Q	GO:0005576	2/6	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG81RS8C	GO:0020037	56/125	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG81RS8C	GO:0005506	56/125	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG81RS8C	GO:0016705	53/125	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG81RS8C	GO:0004497	47/125	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG81RS8C	GO:0070330	2/125	aromatase activity	molecular_function	"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
EOG81RS8C	GO:0007552	1/125	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG81RS8C	GO:0035210	1/125	prepupal development	biological_process	"The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects that undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation." [GOC:mtg_sensu, http://sdb.bio.purdue.edu/fly/aimain/1adult.htm]
EOG81RS8C	GO:0007304	1/125	chorion-containing eggshell formation	biological_process	"The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG81RS8C	GO:0005789	1/125	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG81RS8C	GO:0016712	1/125	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
EOG81RS8C	GO:0007480	1/125	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG81RS8C	GO:0035074	1/125	pupation	biological_process	"The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238]
EOG81RS8C	GO:0008395	1/125	steroid hydroxylase activity	molecular_function	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]
EOG81RS8C	GO:0046344	1/125	ecdysteroid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:ai]
EOG81RS8C	GO:0016021	1/125	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86Q98Z	GO:0003676	27/123	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZW7R2	GO:0016624	1/5	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]
EOG8W6R8Q	GO:0005543	21/112	phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8W6R8Q	GO:0008168	1/112	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8W6R8Q	GO:0008091	1/112	spectrin	cellular_component	"Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194]
EOG8W6R8Q	GO:0016324	1/112	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8W6R8Q	GO:0003676	1/112	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W6R8Q	GO:0030707	1/112	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8W6R8Q	GO:0010797	1/112	regulation of multivesicular body size involved in endosome transport	biological_process	"Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles." [GOC:dph, GOC:tb]
EOG8W6R8Q	GO:0032509	1/112	endosome transport via multivesicular body sorting pathway	biological_process	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]
EOG8W6R8Q	GO:0008092	1/112	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8W6R8Q	GO:0003779	1/112	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8W6R8Q	GO:0042060	1/112	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8W6R8Q	GO:0044267	1/112	cellular protein metabolic process	biological_process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]
EOG8W6R8Q	GO:0004725	1/112	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8W6R8Q	GO:0005524	1/112	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8W6R8Q	GO:0008017	1/112	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8W6R8Q	GO:0016327	1/112	apicolateral plasma membrane	cellular_component	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
EOG8W6R8Q	GO:0000281	1/112	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8W6R8Q	GO:0005515	1/112	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8W6R8Q	GO:0006897	1/112	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8W6R8Q	GO:0007009	1/112	plasma membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8W6R8Q	GO:0045186	1/112	zonula adherens assembly	biological_process	"Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf]
EOG8W6R8Q	GO:0005912	1/112	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8W6R8Q	GO:0016772	1/112	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8RBT06	GO:0009890	2/79	negative regulation of biosynthetic process	biological_process	"Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
EOG8RBT06	GO:0016787	1/79	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8RBT06	GO:0003676	1/79	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8N333J	GO:0016021	2/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8N333J	GO:0007155	2/6	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8W6R8V	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W6R8V	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TF30R	GO:0004386	8/57	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8TF30R	GO:0005524	8/57	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8TF30R	GO:0003677	8/57	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TF30R	GO:0016740	2/57	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG80ZTCC	GO:0016740	1/32	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8PZMMX	GO:0003676	2/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8PZMMX	GO:0046872	2/7	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8935ZM	GO:0003676	1/103	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DNHJZ	GO:0031012	8/43	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8DNHJZ	GO:0008270	8/43	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DNHJZ	GO:0004222	8/43	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8DNHJZ	GO:0005509	3/43	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8K9DS2	GO:0008270	29/131	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8K9DS2	GO:0003700	29/131	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8K9DS2	GO:0005634	29/131	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8J9QDW	GO:0016021	3/7	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J9QDW	GO:0022857	3/7	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8J9QDW	GO:0008643	1/7	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8TF304	GO:0005215	1/5	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8TF304	GO:0008021	1/5	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8TF304	GO:0016020	1/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8X99XK	GO:0016021	1/27	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X99XK	GO:0004930	1/27	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8G1PXB	GO:0016705	2/6	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8G1PXB	GO:0020037	2/6	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8G1PXB	GO:0005506	2/6	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8SN45J	GO:0005856	2/19	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8SN45J	GO:0005737	1/19	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SN45J	GO:0019898	1/19	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8X99XG	GO:0003682	1/6	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8X99XG	GO:0005634	1/6	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X99XG	GO:0003677	1/6	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84N175	GO:0006457	2/6	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG84N175	GO:0007126	1/6	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG84N175	GO:0048477	1/6	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG84N175	GO:0031047	1/6	gene silencing by RNA	biological_process	"Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054]
EOG84N175	GO:0051879	1/6	Hsp90 protein binding	molecular_function	"Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]
EOG84N175	GO:0005737	1/6	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84N175	GO:0003755	1/6	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8G4K96	GO:0007304	7/17	chorion-containing eggshell formation	biological_process	"The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8G4K96	GO:0007275	7/17	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8G4K96	GO:0042600	7/17	chorion	cellular_component	"A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
EOG8G4K96	GO:0005213	7/17	structural constituent of chorion	molecular_function	"The action of a molecule that contributes to the structural integrity of a chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu]
EOG8G4K96	GO:0003899	1/17	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8VDSDT	GO:0015986	2/5	ATP synthesis coupled proton transport	biological_process	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]
EOG8VDSDT	GO:0045261	2/5	proton-transporting ATP synthase complex, catalytic core F(1)	cellular_component	"The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056]
EOG8VDSDT	GO:0046933	2/5	proton-transporting ATP synthase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]
EOG8VDSDT	GO:0046961	2/5	proton-transporting ATPase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]
EOG870WXN	GO:0008484	2/5	sulfuric ester hydrolase activity	molecular_function	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]
EOG8M0HHW	GO:0003677	64/133	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8M0HHW	GO:0007417	4/133	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8M0HHW	GO:0007422	4/133	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8M0HHW	GO:0046982	4/133	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8M0HHW	GO:0061382	4/133	Malpighian tubule tip cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells." [GOC:dph, GOC:mtg_kidney_jan10, PMID:7821213]
EOG8M0HHW	GO:0008407	3/133	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG8M0HHW	GO:0045944	3/133	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8M0HHW	GO:0007400	3/133	neuroblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
EOG8M0HHW	GO:0043565	3/133	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8M0HHW	GO:0007399	3/133	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8M0HHW	GO:0061331	3/133	epithelial cell proliferation involved in Malpighian tubule morphogenesis	biological_process	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG8M0HHW	GO:0007419	3/133	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8M0HHW	GO:0005634	3/133	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8M0HHW	GO:0005667	3/133	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8M0HHW	GO:0007346	2/133	regulation of mitotic cell cycle	biological_process	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8M0HHW	GO:0045893	2/133	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8M0HHW	GO:0007423	2/133	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8M0HHW	GO:0006355	2/133	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8M0HHW	GO:0003700	2/133	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8M0HHW	GO:0007518	1/133	myoblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators]
EOG8M0HHW	GO:0007540	1/133	sex determination, establishment of X:A ratio	biological_process	"The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it." [GOC:isa_complete]
EOG8M0HHW	GO:0006338	1/133	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG8M0HHW	GO:0022008	1/133	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8M0HHW	GO:0002805	1/133	regulation of antimicrobial peptide biosynthetic process	biological_process	"Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
EOG8M0HHW	GO:0048477	1/133	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8M0HHW	GO:0042803	1/133	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8M0HHW	GO:0043066	1/133	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8M0HHW	GO:0007530	1/133	sex determination	biological_process	"Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732]
EOG8M0HHW	GO:0008134	1/133	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8M0HHW	GO:0022416	1/133	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8M0HHW	GO:0005515	1/133	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VDSDC	GO:0005506	27/104	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8VDSDC	GO:0006633	27/104	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8VDSDC	GO:0016021	25/104	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VDSDC	GO:0016491	24/104	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8VDSDC	GO:0000254	3/104	C-4 methylsterol oxidase activity	molecular_function	"Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.13.72, PMID:9811880]
EOG8CNT73	GO:0005576	1/3	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8VDSDF	GO:0022857	2/5	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8VDSDF	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82RGPN	GO:0020037	36/101	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG82RGPN	GO:0032440	2/101	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG82RGPN	GO:0005886	1/101	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG82RGPN	GO:0035100	1/101	ecdysone binding	molecular_function	"Interacting selectively and non-covalently with 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting." [GOC:bf, ISBN:0198506732, ISBN:0582227089]
EOG8VDSD2	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VDSD2	GO:0022857	1/5	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8VDSD2	GO:0022891	1/5	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8VDSD2	GO:0008643	1/5	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8ZSCJ6	GO:0006869	23/125	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG8ZSCJ6	GO:0033868	1/125	Goodpasture-antigen-binding protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein." [EC:2.7.11.9]
EOG8ZSCJ7	GO:0008270	2/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZSCJ7	GO:0004181	2/4	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG8GTNVD	GO:0003723	2/5	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8GTNVD	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VDSD5	GO:0016747	5/16	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG851H5T	GO:0055085	1/4	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG851H5T	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GTNVW	GO:0005615	233/444	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8GTNVW	GO:0010951	13/444	negative regulation of endopeptidase activity	biological_process	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0004867	13/444	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG8GTNVW	GO:0016740	13/444	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8GTNVW	GO:0030162	12/444	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8GTNVW	GO:0045861	10/444	negative regulation of proteolysis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
EOG8GTNVW	GO:0008233	8/444	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8GTNVW	GO:0032504	7/444	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8GTNVW	GO:0000155	6/444	phosphorelay sensor kinase activity	molecular_function	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
EOG8GTNVW	GO:0016020	6/444	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8GTNVW	GO:0019732	1/444	antifungal humoral response	biological_process	"An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8GTNVW	GO:0008063	1/444	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8GTNVW	GO:0002784	1/444	regulation of antimicrobial peptide production	biological_process	"Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
EOG8GTNVW	GO:0003677	1/444	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GTNVW	GO:0005576	1/444	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8GTNVW	GO:0006281	1/444	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8GTNVW	GO:0050829	1/444	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GTNVW	GO:0060570	1/444	negative regulation of peptide hormone processing	biological_process	"Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0006955	1/444	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8GTNVW	GO:0004869	1/444	cysteine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0010955	1/444	negative regulation of protein processing	biological_process	"Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]
EOG8GTNVW	GO:0042562	1/444	hormone binding	molecular_function	"Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
EOG8GTNVW	GO:0045751	1/444	negative regulation of Toll signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8GTNVW	GO:0050832	1/444	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8FBM94	GO:0016597	11/116	amino acid binding	molecular_function	"Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]
EOG8FBM94	GO:0008152	8/116	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8FBM94	GO:0004794	6/116	L-threonine ammonia-lyase activity	molecular_function	"Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [EC:4.3.1.19]
EOG8FBM94	GO:0006567	4/116	threonine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
EOG8FBM94	GO:0003824	1/116	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8M3CRH	GO:0061462	2/78	protein localization to lysosome	biological_process	"A process in which a protein is transported to, or maintained in, a location within a lysosome." [GOC:dph]
EOG8M3CRH	GO:0043087	2/78	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8M3CRH	GO:0071986	2/78	Ragulator complex	cellular_component	"A protein complex that contains MAPKSP1 (MP1, Map2k1ip1), ROBLD3 (p14, Mapbpip), C11orf59 (p18), LAMTOR4 and LAMTOR5. The complex is anchored to lipid rafts in late endosome membranes via C11orf59, recruits mTORC1 to lysosomal membranes in amino acid signaling to mTORC1, constitutes a guanine nucleotide exchange factor (GEF) for the Rag GTPases, and is also involved in ERK/MAPK signaling." [GOC:lb, PMID:19177150, PMID:20381137, PMID:22980980]
EOG8M3CRH	GO:0008361	2/78	regulation of cell size	biological_process	"Any process that modulates the size of a cell." [GOC:go_curators]
EOG8M3CRH	GO:0071230	2/78	cellular response to amino acid stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:mah]
EOG8M3CRH	GO:0032008	2/78	positive regulation of TOR signaling	biological_process	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8M3CRH	GO:0005764	2/78	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8K0T34	GO:0022857	1/4	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8K0T34	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87M4DS	GO:0004252	2/4	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8K0T36	GO:0004252	3/5	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG89360M	GO:0005549	3/8	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8S4RWT	GO:0003824	6/66	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8S4RWT	GO:0016787	2/66	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8S4RWT	GO:0004715	1/66	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG886BTX	GO:0016905	1/151	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG886BTX	GO:0004550	1/151	nucleoside diphosphate kinase activity	molecular_function	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]
EOG886BTX	GO:0006241	1/151	CTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]
EOG886BTX	GO:0006228	1/151	UTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732]
EOG886BTX	GO:0006183	1/151	GTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG886BTX	GO:0005524	1/151	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG886BTX	GO:0010506	1/151	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8B5RMJ	GO:0005615	1/4	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG883GJG	GO:0005524	30/126	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG883GJG	GO:0003676	29/126	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG883GJG	GO:0008026	27/126	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG883GJG	GO:0004386	3/126	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG883GJG	GO:0008152	1/126	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG883GJG	GO:0006200	1/126	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG883GJG	GO:0002151	1/126	G-quadruplex RNA binding	molecular_function	"Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad." [PMID:18294969, PMID:18568163, PMID:19330720]
EOG883GJG	GO:0004004	1/126	ATP-dependent RNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]
EOG886BTT	GO:0003676	4/9	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG886BTT	GO:0005634	3/9	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG886BTT	GO:0008270	3/9	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG886BTT	GO:0046872	1/9	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89360G	GO:0003676	70/406	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89360G	GO:0005634	11/406	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG89360G	GO:0003700	9/406	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG89360G	GO:0003707	9/406	steroid hormone receptor activity	molecular_function	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
EOG89360G	GO:0006351	8/406	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG89360G	GO:0046872	3/406	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89360G	GO:0003964	2/406	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG89360G	GO:0003723	2/406	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG89360G	GO:0005506	1/406	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG89360G	GO:0042981	1/406	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG89360G	GO:0003677	1/406	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG89360G	GO:0008270	1/406	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG89360G	GO:0019058	1/406	viral life cycle	biological_process	"A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]
EOG89360G	GO:0005622	1/406	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG89360G	GO:0006886	1/406	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG883GJC	GO:0015629	1/4	actin cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
EOG883GJC	GO:0007155	1/4	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG883GJC	GO:0005198	1/4	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG89360C	GO:0016787	1/6	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG886BTN	GO:0016020	1/4	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG886BTN	GO:0005549	1/4	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG886BTN	GO:0004984	1/4	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG85HVB3	GO:0007050	22/139	cell cycle arrest	biological_process	"A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]
EOG85HVB3	GO:0005509	22/139	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG85HVB3	GO:0005856	19/139	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG85HVB3	GO:0016204	1/139	determination of muscle attachment site	biological_process	"The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete]
EOG85HVB3	GO:0051491	1/139	positive regulation of filopodium assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG85HVB3	GO:0035149	1/139	lumen formation, open tracheal system	biological_process	"Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
EOG85HVB3	GO:0000226	1/139	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG85HVB3	GO:0035147	1/139	branch fusion, open tracheal system	biological_process	"Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584]
EOG85HVB3	GO:0016203	1/139	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG85HVB3	GO:0007475	1/139	apposition of dorsal and ventral imaginal disc-derived wing surfaces	biological_process	"The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu]
EOG85HVB3	GO:0048813	1/139	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG85HVB3	GO:0005912	1/139	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG85HVB3	GO:0045169	1/139	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG85HVB3	GO:0030716	1/139	oocyte fate determination	biological_process	"The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
EOG85HVB3	GO:0045773	1/139	positive regulation of axon extension	biological_process	"Any process that activates or increases the frequency, rate or extent of axon extension." [GOC:go_curators]
EOG85HVB3	GO:0030175	1/139	filopodium	cellular_component	"Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194]
EOG85HVB3	GO:0008017	1/139	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG85HVB3	GO:0000235	1/139	astral microtubule	cellular_component	"Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194]
EOG85HVB3	GO:0003779	1/139	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG85HVB3	GO:0030036	1/139	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG85HVB3	GO:0007423	1/139	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG85HVB3	GO:0007017	1/139	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG85HVB3	GO:0004725	1/139	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG85HVB3	GO:0007424	1/139	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG85HVB3	GO:0007409	1/139	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG85HVB3	GO:0005874	1/139	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG85HVB3	GO:0044295	1/139	axonal growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954]
EOG85HVB3	GO:0016199	1/139	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG85HVB3	GO:0007026	1/139	negative regulation of microtubule depolymerization	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]
EOG85HVB3	GO:0030426	1/139	growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194]
EOG85HVB3	GO:0008092	1/139	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG85HVB3	GO:0005515	1/139	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG85HVB3	GO:0016319	1/139	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG85HVB3	GO:0030516	1/139	regulation of axon extension	biological_process	"Any process that modulates the rate, direction or extent of axon extension." [GOC:go_curators]
EOG85HVB3	GO:0035371	1/139	microtubule plus-end	cellular_component	"The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]
EOG85HVB3	GO:0001578	1/139	microtubule bundle formation	biological_process	"A process that results in a parallel arrangement of microtubules." [GOC:dph]
EOG8B5RMV	GO:0003677	5/28	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG886BTK	GO:0003676	1/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG886BTK	GO:0046872	1/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89360V	GO:0016740	1/7	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8JT2KG	GO:0005524	2/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8JT2KG	GO:0042623	1/5	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8JT2KG	GO:0007031	1/5	peroxisome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
EOG8JT2KG	GO:0005778	1/5	peroxisomal membrane	cellular_component	"The lipid bilayer surrounding a peroxisome." [GOC:mah]
EOG8JT2KG	GO:0005777	1/5	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8JT2KG	GO:0006625	1/5	protein targeting to peroxisome	biological_process	"The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai]
EOG8616MV	GO:0000155	1/5	phosphorelay sensor kinase activity	molecular_function	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
EOG8616MV	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8616MV	GO:0071555	1/5	cell wall organization	biological_process	"A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah]
EOG8K0T3X	GO:0016021	2/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VQD4K	GO:0006807	66/157	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG8VQD4K	GO:0016810	49/157	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
EOG8VQD4K	GO:0000257	15/157	nitrilase activity	molecular_function	"Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd]
EOG8VQD4K	GO:0004328	2/157	formamidase activity	molecular_function	"Catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+)." [EC:3.5.1.49, RHEA:21951]
EOG8323DG	GO:0008270	9/63	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8323DG	GO:0003755	1/63	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8323DG	GO:0006457	1/63	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8CC6GC	GO:0008270	5/10	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CC6GC	GO:0003676	5/10	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CC6GC	GO:0005634	5/10	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8H1DBQ	GO:0008270	3/25	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8H1DBQ	GO:0003676	3/25	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8H1DBQ	GO:0004190	1/25	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8323DQ	GO:0004930	1/4	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8323DQ	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8323DX	GO:0016491	12/27	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8N332S	GO:0004725	2/5	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8W6R9D	GO:0046872	15/64	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8W6R9D	GO:0003676	6/64	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82FW0K	GO:0016740	9/186	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG82FW0K	GO:0004364	2/186	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG82FW0K	GO:0005811	1/186	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG82FW0K	GO:0050220	1/186	prostaglandin-E synthase activity	molecular_function	"Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)." [EC:5.3.99.3, RHEA:12896]
EOG8W6R9P	GO:0046872	2/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8KM1JC	GO:0004888	1/4	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8KM1JC	GO:0007166	1/4	cell surface receptor signaling pathway	biological_process	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
EOG8KM1JC	GO:0016020	1/4	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8KM1JC	GO:0004930	1/4	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8KM1JC	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WDGSN	GO:0004742	21/95	dihydrolipoyllysine-residue acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12]
EOG8WDGSN	GO:0045254	20/95	pyruvate dehydrogenase complex	cellular_component	"Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3)." [ISBN:0716720094]
EOG8WDGSN	GO:0006090	20/95	pyruvate metabolic process	biological_process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]
EOG8WDGSN	GO:0016746	5/95	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8WDGSN	GO:0043754	2/95	dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity	molecular_function	"Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine." [EC:2.3.1.168]
EOG8WDGSN	GO:0005811	1/95	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8WDGSH	GO:0004725	2/5	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8WDGSF	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WDGSF	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WDGSD	GO:0008233	2/6	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8M947F	GO:0005975	32/195	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8M947F	GO:0004553	32/195	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8M947F	GO:0045088	1/195	regulation of innate immune response	biological_process	"Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8M947F	GO:0032491	1/195	detection of molecule of fungal origin	biological_process	"The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal." [GOC:mah, GOC:rl]
EOG8M947F	GO:0009986	1/195	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8M947F	GO:0002758	1/195	innate immune response-activating signal transduction	biological_process	"The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8M947F	GO:0045087	1/195	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8M947F	GO:0002221	1/195	pattern recognition receptor signaling pathway	biological_process	"Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
EOG8M947F	GO:0051607	1/195	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG8M947F	GO:0008329	1/195	signaling pattern recognition receptor activity	molecular_function	"Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity." [GOC:ar, PMID:12507420, PMID:12925128, PMID:14523544, Wikipedia:Pattern_recognition_receptor]
EOG8M947F	GO:0001872	1/195	(1->3)-beta-D-glucan binding	molecular_function	"Interacting selectively and non-covalently with (1->3)-beta-D-glucans." [PMID:14707091]
EOG8M947F	GO:0009620	1/195	response to fungus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
EOG8M947F	GO:0005576	1/195	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG82FW00	GO:0005509	26/84	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG82FW00	GO:0016301	2/84	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG82FW00	GO:0006184	1/84	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG82FW00	GO:0003924	1/84	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8W6R95	GO:0003924	29/112	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8W6R95	GO:0005525	29/112	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8W6R95	GO:0005783	2/112	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8W6R95	GO:0007030	1/112	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8W6R95	GO:0016021	1/112	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W6R95	GO:0005509	1/112	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8W6R95	GO:0005515	1/112	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8W6R95	GO:0007528	1/112	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8W6R95	GO:0042802	1/112	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG8W6R95	GO:0016320	1/112	endoplasmic reticulum membrane fusion	biological_process	"The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum." [GOC:elh, GOC:jid]
EOG8W6R95	GO:0016020	1/112	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8W6R95	GO:0042803	1/112	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8W6R95	GO:0006184	1/112	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8W6R95	GO:0000139	1/112	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8W6R95	GO:0031227	1/112	intrinsic component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
EOG8W6R95	GO:0007517	1/112	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8W6R95	GO:0061025	1/112	membrane fusion	biological_process	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]
EOG8W6R95	GO:0007029	1/112	endoplasmic reticulum organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
EOG8W6R95	GO:0051124	1/112	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8W6R95	GO:0006457	1/112	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8W6R95	GO:0008582	1/112	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8W6R95	GO:0032561	1/112	guanyl ribonucleotide binding	molecular_function	"Interacting selectively and non-covalently with a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
EOG8W6R95	GO:0005794	1/112	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8W6R95	GO:0007019	1/112	microtubule depolymerization	biological_process	"The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194]
EOG8W6R95	GO:0005737	1/112	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8W6R95	GO:0051260	1/112	protein homooligomerization	biological_process	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
EOG8W6R95	GO:0031114	1/112	regulation of microtubule depolymerization	biological_process	"Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah]
EOG8M947N	GO:0006814	1/3	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8M947N	GO:0005890	1/3	sodium:potassium-exchanging ATPase complex	cellular_component	"Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732]
EOG8M947N	GO:0006813	1/3	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8WDGSR	GO:0005622	7/98	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8WDGSR	GO:0005215	7/98	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8WDGSR	GO:0005501	1/98	retinoid binding	molecular_function	"Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732]
EOG8WDGSR	GO:0007602	1/98	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG8WDGSR	GO:0016063	1/98	rhodopsin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
EOG80GG4R	GO:0046331	1/96	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8QNQ9R	GO:0005524	3/6	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QNQ9R	GO:0004672	3/6	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8N8TJT	GO:0018149	23/73	peptide cross-linking	biological_process	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]
EOG8N8TJT	GO:0003810	21/73	protein-glutamine gamma-glutamyltransferase activity	molecular_function	"Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124]
EOG8N8TJT	GO:0046872	10/73	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83R61K	GO:0007633	1/104	pattern orientation	biological_process	"The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes." [GOC:jid, PMID:9933535]
EOG83R61K	GO:0042059	1/104	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG83R61K	GO:0005634	1/104	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83R61K	GO:0007628	1/104	adult walking behavior	biological_process	"The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907]
EOG83R61K	GO:0008586	1/104	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG8QNQ9C	GO:0016021	26/50	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QNQ9C	GO:0055085	20/50	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8QNQ9C	GO:0005215	13/50	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8QNQ9C	GO:0022857	6/50	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8QNQ9G	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8QNQ9G	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QNQ9G	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88GZJK	GO:0005549	3/9	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG88GZJK	GO:0004930	3/9	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG88GZJK	GO:0016021	3/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88GZJK	GO:0004984	3/9	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG88GZJK	GO:0005886	1/9	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG88GZJH	GO:0006633	2/4	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG88GZJH	GO:0016740	2/4	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG88GZJH	GO:0016021	2/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8909Q4	GO:0005089	2/26	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8N06WD	GO:0004725	28/97	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8N06WD	GO:0008138	19/97	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG8N06WD	GO:0017017	12/97	MAP kinase tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]
EOG8N06WD	GO:0006470	3/97	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8N06WD	GO:0048749	1/97	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8N06WD	GO:0001736	1/97	establishment of planar polarity	biological_process	"Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
EOG8N06WD	GO:0071907	1/97	determination of digestive tract left/right asymmetry	biological_process	"Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:cvs]
EOG8N06WD	GO:0034599	1/97	cellular response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
EOG8N06WD	GO:0035335	1/97	peptidyl-tyrosine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
EOG8N06WD	GO:0004721	1/97	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8N06WD	GO:0007396	1/97	suture of dorsal opening	biological_process	"Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138]
EOG8N06WD	GO:0007422	1/97	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8N06WD	GO:0048615	1/97	embryonic anterior midgut (ectodermal) morphogenesis	biological_process	"The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc]
EOG8N06WD	GO:0008362	1/97	chitin-based embryonic cuticle biosynthetic process	biological_process	"Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232]
EOG8N06WD	GO:0008340	1/97	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8N06WD	GO:0000188	1/97	inactivation of MAPK activity	biological_process	"Any process that terminates the activity of the active enzyme MAP kinase." [PMID:9561267]
EOG8N06WD	GO:0030707	1/97	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8N06WD	GO:0030036	1/97	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8N06WD	GO:0005794	1/97	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8N06WD	GO:0046528	1/97	imaginal disc fusion	biological_process	"The process following disc eversion whereby imaginal discs fuse with adjacent disc derivatives to form a continuous adult epidermis." [PMID:11494317]
EOG8N06WD	GO:0050778	1/97	positive regulation of immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
EOG8N06WD	GO:0007015	1/97	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8N06WD	GO:0043066	1/97	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8N06WD	GO:0009306	1/97	protein secretion	biological_process	"The controlled release of proteins from a cell." [GOC:ai]
EOG8N06WD	GO:0016318	1/97	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG8N06WD	GO:0046844	1/97	micropyle formation	biological_process	"Establishment of the micropyle, a single cone-shaped specialization of the chorion that allows sperm entry into the egg prior to fertilization." [ISBN:0879694238]
EOG8N06WD	GO:0016301	1/97	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8N06WD	GO:0010389	1/97	regulation of G2/M transition of mitotic cell cycle	biological_process	"Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:17329565]
EOG8N06WD	GO:0007561	1/97	imaginal disc eversion	biological_process	"The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317]
EOG8N06WD	GO:0007254	1/97	JNK cascade	biological_process	"An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974]
EOG8N06WD	GO:0008579	1/97	JUN kinase phosphatase activity	molecular_function	"Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate." [GOC:mah]
EOG8N06WD	GO:0006979	1/97	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8N06WD	GO:0005783	1/97	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8N06WD	GO:0070303	1/97	negative regulation of stress-activated protein kinase signaling cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade." [GOC:mah]
EOG8N06WD	GO:0008544	1/97	epidermis development	biological_process	"The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]
EOG8N06WD	GO:0046329	1/97	negative regulation of JNK cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8N06WD	GO:0046843	1/97	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8N06WD	GO:0008360	1/97	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8N06WD	GO:0042060	1/97	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8N06WD	GO:0007391	1/97	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8N06WD	GO:0007298	1/97	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8N06WD	GO:0046529	1/97	imaginal disc fusion, thorax closure	biological_process	"The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm]
EOG8J9QGQ	GO:0004984	1/3	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8J9QGQ	GO:0016020	1/3	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8J9QGQ	GO:0005549	1/3	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8SN42X	GO:0003824	27/204	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8SN42X	GO:0004802	3/204	transketolase activity	molecular_function	"Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [EC:2.2.1.1, GOC:fmc]
EOG8SN42X	GO:0005875	2/204	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8SN42X	GO:0031122	2/204	cytoplasmic microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
EOG8SN42X	GO:0090063	1/204	positive regulation of microtubule nucleation	biological_process	"Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
EOG8SN42X	GO:0000922	1/204	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8SN42X	GO:0005515	1/204	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8SN42X	GO:0005813	1/204	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8SN42X	GO:0007067	1/204	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8SN42X	GO:0007029	1/204	endoplasmic reticulum organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
EOG8SN42X	GO:0008017	1/204	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8SN42X	GO:0007143	1/204	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8SN42X	GO:0048477	1/204	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8SN42X	GO:0035371	1/204	microtubule plus-end	cellular_component	"The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]
EOG8SN42X	GO:0045450	1/204	bicoid mRNA localization	biological_process	"Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators]
EOG8SN42X	GO:0031935	1/204	regulation of chromatin silencing	biological_process	"Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah]
EOG8SN42X	GO:0007344	1/204	pronuclear fusion	biological_process	"The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X]
EOG8SN42X	GO:0016325	1/204	oocyte microtubule cytoskeleton organization	biological_process	"Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]
EOG8SN42X	GO:0005811	1/204	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8SN42X	GO:0007017	1/204	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8SN42X	GO:0000022	1/204	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8SN42X	GO:0007411	1/204	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8SN42X	GO:0015631	1/204	tubulin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]
EOG8MWBM4	GO:0004930	28/49	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8MWBM4	GO:0006950	22/49	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8MWBM4	GO:0016021	20/49	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8MWBM4	GO:0016020	7/49	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8MWBM4	GO:0005886	4/49	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8MWBM4	GO:0042594	3/49	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8MWBM4	GO:0008340	3/49	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8MWBM4	GO:0007186	2/49	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8GXJ25	GO:0016829	1/84	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8KPWRH	GO:0007165	4/40	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8KPWRM	GO:0006884	1/234	cell volume homeostasis	biological_process	"Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8KPWRM	GO:0006821	1/234	chloride transport	biological_process	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8KPWRM	GO:0016021	1/234	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KPWRM	GO:0072320	1/234	volume-sensitive chloride channel activity	molecular_function	"Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:mah]
EOG8KPWRM	GO:0044070	1/234	regulation of anion transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
EOG8KPWRM	GO:0005254	1/234	chloride channel activity	molecular_function	"Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8KPWRM	GO:1902476	1/234	chloride transmembrane transport	biological_process	"The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw]
EOG8KPWRM	GO:0005777	1/234	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8N06W6	GO:0016491	2/6	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8MWBM1	GO:0008152	40/136	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8MWBM1	GO:0051539	34/136	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8MWBM1	GO:0003994	5/136	aconitate hydratase activity	molecular_function	"Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw]
EOG8MWBM1	GO:0007370	1/136	ventral furrow formation	biological_process	"Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238]
EOG8MWBM1	GO:0030350	1/136	iron-responsive element binding	molecular_function	"Interacting selectively and non-covalently with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins." [PMID:3198610, PMID:8710843]
EOG8N06W0	GO:0016788	36/152	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG8N06W0	GO:0090502	1/152	RNA phosphodiester bond hydrolysis, endonucleolytic	biological_process	"The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
EOG8N06W0	GO:0046872	1/152	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8N06W0	GO:0003723	1/152	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8N06W0	GO:0006955	1/152	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8N06W0	GO:0030247	1/152	polysaccharide binding	molecular_function	"Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah]
EOG8N06W0	GO:0005576	1/152	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8N06W0	GO:0005044	1/152	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8N06W0	GO:0008233	1/152	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8N06W0	GO:0004521	1/152	endoribonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8909QW	GO:0022857	1/4	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8909QW	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88GZJ2	GO:0008270	1/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG88GZJ2	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88GZJ2	GO:0005634	1/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8DFS2Q	GO:0005515	1/95	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8DFS2Q	GO:0045893	1/95	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8DFS2Q	GO:0042981	1/95	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8DFS2Q	GO:0006979	1/95	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8DFS2Q	GO:0008270	1/95	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DFS2Q	GO:0008340	1/95	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8DFS2R	GO:0008270	4/85	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DFS2R	GO:0003676	2/85	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DFS2W	GO:0006886	2/54	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8DFS2W	GO:0046872	1/54	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DFS2W	GO:0000016	1/54	lactase activity	molecular_function	"Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [EC:3.2.1.108]
EOG851H4R	GO:0006629	31/166	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG851H4R	GO:0004806	30/166	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG851H4R	GO:0007602	1/166	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG851H4R	GO:0005737	1/166	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG851H4R	GO:0007155	1/166	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG851H4R	GO:0031532	1/166	actin cytoskeleton reorganization	biological_process	"A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]
EOG851H4R	GO:0004465	1/166	lipoprotein lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein." [EC:3.1.1.34, GOC:bf]
EOG851H4T	GO:0016021	7/26	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG851H4T	GO:0016491	7/26	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG84F8R7	GO:0004984	2/6	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG84F8R7	GO:0016020	2/6	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG84F8R7	GO:0005549	2/6	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG85F03Z	GO:0005975	6/25	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG85F03Z	GO:0005737	4/25	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG85F03Z	GO:0004564	4/25	beta-fructofuranosidase activity	molecular_function	"Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside." [EC:3.2.1.26, MetaCyc:RXN-9985]
EOG85F03Z	GO:0004553	2/25	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8TF31J	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TF31J	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8TF31J	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG85F03H	GO:0030170	119/445	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG85F03H	GO:0006520	119/445	cellular amino acid metabolic process	biological_process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]
EOG85F03H	GO:0016831	110/445	carboxy-lyase activity	molecular_function	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]
EOG85F03H	GO:0004058	9/445	aromatic-L-amino-acid decarboxylase activity	molecular_function	"Catalysis of the reaction: L-amino acid + H+ = R-H + CO2." [EC:4.1.1.28]
EOG85F03H	GO:0016491	6/445	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG85F03H	GO:0006584	2/445	catecholamine metabolic process	biological_process	"The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0042302	2/445	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG85F03H	GO:0043052	2/445	thermotaxis	biological_process	"The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
EOG85F03H	GO:0040003	2/445	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG85F03H	GO:0004837	2/445	tyrosine decarboxylase activity	molecular_function	"Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25]
EOG85F03H	GO:0042423	2/445	catecholamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0007611	1/445	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG85F03H	GO:0048066	1/445	developmental pigmentation	biological_process	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
EOG85F03H	GO:0035220	1/445	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG85F03H	GO:0007626	1/445	locomotory behavior	biological_process	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
EOG85F03H	GO:0007619	1/445	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG85F03H	GO:0046592	1/445	polyamine oxidase activity	molecular_function	"Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380]
EOG85F03H	GO:0048148	1/445	behavioral response to cocaine	biological_process	"Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid]
EOG85F03H	GO:0048082	1/445	regulation of adult chitin-containing cuticle pigmentation	biological_process	"Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
EOG85F03H	GO:0048085	1/445	adult chitin-containing cuticle pigmentation	biological_process	"Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
EOG85F03H	GO:0007615	1/445	anesthesia-resistant memory	biological_process	"The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531]
EOG85F03H	GO:0006587	1/445	serotonin biosynthetic process from tryptophan	biological_process	"The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0048149	1/445	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG85F03H	GO:0009611	1/445	response to wounding	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators]
EOG85F03H	GO:0040040	1/445	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG85F03H	GO:0018991	1/445	oviposition	biological_process	"The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems]
EOG85F03H	GO:0019239	1/445	deaminase activity	molecular_function	"Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl]
EOG85F03H	GO:0040007	1/445	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG85F03H	GO:0008062	1/445	eclosion rhythm	biological_process	"The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043]
EOG85F03H	GO:0004398	1/445	histidine decarboxylase activity	molecular_function	"Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22]
EOG85F03H	GO:0006585	1/445	dopamine biosynthetic process from tyrosine	biological_process	"The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine." [GOC:bf, GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0007616	1/445	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8TF31G	GO:0016491	2/5	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8PZMNV	GO:0008889	21/71	glycerophosphodiester phosphodiesterase activity	molecular_function	"Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]
EOG8PZMNV	GO:0006071	21/71	glycerol metabolic process	biological_process	"The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]
EOG8PZMNV	GO:0006629	21/71	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8PZMNV	GO:0005272	1/71	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8PZMNV	GO:0016020	1/71	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8PZMNV	GO:0048812	1/71	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8PZMNG	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PZMNG	GO:0022857	2/5	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8B0137	GO:0004198	1/6	calcium-dependent cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]
EOG8B0137	GO:0005622	1/6	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8PZMNN	GO:0016491	24/95	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8PZMNN	GO:0030060	2/95	L-malate dehydrogenase activity	molecular_function	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]
EOG8284GD	GO:0004888	1/5	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8284GD	GO:0007166	1/5	cell surface receptor signaling pathway	biological_process	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
EOG8284GD	GO:0016020	1/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8X0Q7B	GO:0016021	4/14	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X0Q7B	GO:0022857	3/14	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8X0Q7B	GO:0008643	1/14	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8X0Q7B	GO:0022891	1/14	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8284GW	GO:0008234	17/51	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8284GW	GO:0016740	1/51	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG83N9SS	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83N9SQ	GO:0016021	2/103	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83N9SQ	GO:0004721	1/103	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG86HJS9	GO:0042302	6/17	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG86HJS8	GO:0005524	50/177	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG86HJS8	GO:0019205	33/177	nucleobase-containing compound kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]
EOG86HJS8	GO:0006139	33/177	nucleobase-containing compound metabolic process	biological_process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
EOG86HJS8	GO:0004017	17/177	adenylate kinase activity	molecular_function	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]
EOG86HJS8	GO:0046034	14/177	ATP metabolic process	biological_process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]
EOG86HJS8	GO:0005737	14/177	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86HJS8	GO:0046939	1/177	nucleotide phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]
EOG86HJS8	GO:0004849	1/177	uridine kinase activity	molecular_function	"Catalysis of the reaction: ATP + uridine = ADP + UMP." [EC:2.7.1.48]
EOG8W6RD1	GO:0003676	26/237	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W6RD1	GO:0008270	25/237	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8W6RD1	GO:0003677	1/237	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8W6RD1	GO:0004523	1/237	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8W6RD1	GO:0003964	1/237	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8W6RD1	GO:0003723	1/237	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8R7XQG	GO:0004842	22/126	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8R7XQG	GO:0008270	22/126	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8R7XQG	GO:0007601	2/126	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8R7XQG	GO:0050896	2/126	response to stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
EOG8R7XQG	GO:0005516	2/126	calmodulin binding	molecular_function	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
EOG8R7XQG	GO:0005319	2/126	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG8R7XQG	GO:0007291	2/126	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8R7XQG	GO:0007286	2/126	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG8R7XQG	GO:0007399	1/126	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8R7XQG	GO:0042066	1/126	perineurial glial growth	biological_process	"Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons." [GOC:mah, PMID:11517334, PMID:18176560]
EOG8R7XQG	GO:0042065	1/126	glial cell growth	biological_process	"Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jid]
EOG8616N8	GO:0003676	7/1106	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8616N8	GO:0003677	3/1106	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8616N8	GO:0008270	3/1106	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8616N8	GO:0003964	2/1106	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8616N8	GO:0015074	2/1106	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8616N8	GO:0003723	2/1106	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8616N8	GO:0004190	1/1106	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8616N8	GO:0008237	1/1106	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG86HJSV	GO:0034498	1/3	early endosome to Golgi transport	biological_process	"The directed movement of substances from early endosomes to the Golgi." [GOC:rb]
EOG86HJSV	GO:0006886	1/3	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG86HJSV	GO:0031901	1/3	early endosome membrane	cellular_component	"The lipid bilayer surrounding an early endosome." [GOC:pz]
EOG86HJSV	GO:0035091	1/3	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG847J76	GO:0030976	2/4	thiamine pyrophosphate binding	molecular_function	"Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [CHEBI:45931, GOC:mlg]
EOG847J76	GO:0004591	2/4	oxoglutarate dehydrogenase (succinyl-transferring) activity	molecular_function	"Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2]
EOG847J76	GO:0006099	2/4	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8284G1	GO:0005524	43/145	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8284G1	GO:0045261	41/145	proton-transporting ATP synthase complex, catalytic core F(1)	cellular_component	"The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056]
EOG8284G1	GO:0046933	40/145	proton-transporting ATP synthase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]
EOG8284G1	GO:0015986	40/145	ATP synthesis coupled proton transport	biological_process	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]
EOG8284G1	GO:0015991	39/145	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8284G1	GO:0015992	3/145	proton transport	biological_process	"The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
EOG8284G1	GO:0005811	2/145	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8284G1	GO:0005743	2/145	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8284G1	GO:0046034	2/145	ATP metabolic process	biological_process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]
EOG8284G1	GO:0048515	1/145	spermatid differentiation	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid]
EOG8284G1	GO:0016787	1/145	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8284G1	GO:0010155	1/145	regulation of proton transport	biological_process	"Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:sm]
EOG8284G1	GO:0046331	1/145	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8284G1	GO:0005739	1/145	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8284G1	GO:0008340	1/145	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8284G1	GO:0006754	1/145	ATP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]
EOG8284G8	GO:0016021	294/728	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8284G8	GO:0055085	283/728	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8284G8	GO:0005215	14/728	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8284G8	GO:0015114	10/728	phosphate ion transmembrane transporter activity	molecular_function	"Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai]
EOG8284G8	GO:0005886	2/728	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8284G8	GO:0006814	2/728	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8284G8	GO:0015293	2/728	symporter activity	molecular_function	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
EOG8284G8	GO:0005314	1/728	high-affinity glutamate transmembrane transporter activity	molecular_function	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.3.10.5]
EOG8284G8	GO:0015321	1/728	sodium-dependent phosphate transmembrane transporter activity	molecular_function	"Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions." [GOC:jl]
EOG8284G8	GO:0051938	1/728	L-glutamate import	biological_process	"The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah]
EOG8284G8	GO:0048190	1/728	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8284G8	GO:0006541	1/728	glutamine metabolic process	biological_process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
EOG8284G8	GO:0035725	1/728	sodium ion transmembrane transport	biological_process	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
EOG8284G8	GO:0001666	1/728	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG8284G8	GO:0007005	1/728	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8284G8	GO:0035435	1/728	phosphate ion transmembrane transport	biological_process	"The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
EOG8284G8	GO:0044341	1/728	sodium-dependent phosphate transport	biological_process	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl]
EOG8284G8	GO:0005436	1/728	sodium:phosphate symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai]
EOG8284G8	GO:0004930	1/728	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8M946T	GO:0004692	1/94	cGMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
EOG8M946T	GO:0016301	1/94	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8TQPR1	GO:0016747	1/5	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG83V297	GO:0003920	7/48	GMP reductase activity	molecular_function	"Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH." [EC:1.7.1.7, RHEA:17188]
EOG83V297	GO:0009117	7/48	nucleotide metabolic process	biological_process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]
EOG83V297	GO:0046872	7/48	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83V297	GO:1902560	6/48	GMP reductase complex	cellular_component	"A protein complex which is capable of GMP reductase activity. It catalysis of the irreversible reaction: IMP + NADP(+) + NH(4)(+) <= GMP + 2 H(+) + NADPH." [GOC:bhm, GOC:TermGenie, PMID:12009299]
EOG8M946F	GO:0003676	2/3	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M946F	GO:0046872	2/3	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81K1V1	GO:0051537	2/5	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG81K1V1	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81K1V1	GO:0016491	2/5	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8SXQWH	GO:0008430	1/4	selenium binding	molecular_function	"Interacting selectively and non-covalently with selenium (Se)." [GOC:ai]
EOG8SXQWH	GO:0030176	1/4	integral component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
EOG8SXQWH	GO:0006886	1/4	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG898XF5	GO:0032580	21/51	Golgi cisterna membrane	cellular_component	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]
EOG898XF5	GO:0016758	19/51	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG898XF5	GO:0008376	1/51	acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]
EOG898XF5	GO:0030206	1/51	chondroitin sulfate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732]
EOG898XF5	GO:0047237	1/51	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP." [EC:2.4.1.174, MetaCyc:2.4.1.174-RXN]
EOG898XF5	GO:0042060	1/51	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG83R62Q	GO:0003676	55/341	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83R62Q	GO:0005622	1/341	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG83R62Q	GO:0008270	1/341	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83R62Q	GO:0046872	1/341	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83R62Q	GO:0003964	1/341	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG83R62Q	GO:0003723	1/341	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG83R62Q	GO:0042981	1/341	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG873S65	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG873S65	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V9X5J	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V9X5J	GO:0006633	1/5	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8V9X5J	GO:0016717	1/5	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]
EOG873S68	GO:0055085	2/6	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG873S68	GO:0016021	2/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V9X5F	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V9X5F	GO:0005634	1/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8V9X5F	GO:0046872	1/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8V9X5F	GO:0008270	1/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V9X5B	GO:0004222	2/6	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8V9X5B	GO:0008270	2/6	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V9X5B	GO:0031012	2/6	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8M0HGJ	GO:0048471	1/134	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8M0HGJ	GO:0007097	1/134	nuclear migration	biological_process	"The directed movement of the nucleus." [GOC:ai]
EOG8M0HGJ	GO:0034399	1/134	nuclear periphery	cellular_component	"The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah]
EOG8V9X58	GO:0005098	29/96	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8V9X58	GO:0007165	23/96	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8V9X58	GO:0032853	1/96	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8V9X58	GO:0048471	1/96	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8V9X58	GO:0045132	1/96	meiotic chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah]
EOG8V9X58	GO:0006913	1/96	nucleocytoplasmic transport	biological_process	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]
EOG8V9X58	GO:0006611	1/96	protein export from nucleus	biological_process	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]
EOG8V9X58	GO:0022008	1/96	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG873S6D	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG873S6D	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8V9X54	GO:0003682	2/10	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG83R622	GO:0045454	6/37	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG83R622	GO:0015035	5/37	protein disulfide oxidoreductase activity	molecular_function	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]
EOG83R622	GO:0006662	5/37	glycerol ether metabolic process	biological_process	"The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732]
EOG83R622	GO:0003756	1/37	protein disulfide isomerase activity	molecular_function	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1]
EOG873S6J	GO:0016020	23/85	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG873S6J	GO:0016757	22/85	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG873S6J	GO:0033829	1/85	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor." [EC:2.4.1.222]
EOG83R625	GO:0046872	2/7	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83R625	GO:0003676	2/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG898XFM	GO:0046872	4/13	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG854CJ4	GO:0005576	1/7	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG854CJ4	GO:0042742	1/7	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG898XFH	GO:0016020	2/32	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG898XFH	GO:0006955	2/32	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8M3CSC	GO:0005811	1/109	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8M3CSN	GO:0071011	1/71	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8M3CSN	GO:0000398	1/71	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8M3CSN	GO:0071013	1/71	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8M0HGW	GO:0005328	2/6	neurotransmitter:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
EOG8M0HGW	GO:0016021	2/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M3CSJ	GO:0008080	2/4	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG8TTJXT	GO:0005581	13/81	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8TTJXT	GO:0005201	12/81	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG8HX7FQ	GO:0008092	1/100	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8HX7FQ	GO:0001654	1/100	eye development	biological_process	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
EOG8HX7FQ	GO:0042052	1/100	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8HX7FQ	GO:0016013	1/100	syntrophin complex	cellular_component	"A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [http://www.dmd.nl/DGC.html#syn]
EOG8HX7FQ	GO:0008582	1/100	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG83JFN4	GO:0008270	14/61	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83JFN4	GO:0005680	13/61	anaphase-promoting complex	cellular_component	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]
EOG83JFN4	GO:0004842	12/61	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG83JFN4	GO:0031145	1/61	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [PMID:15380083]
EOG83JFN4	GO:0045842	1/61	positive regulation of mitotic metaphase/anaphase transition	biological_process	"Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
EOG83JFN4	GO:0000151	1/61	ubiquitin ligase complex	cellular_component	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
EOG83JFN4	GO:0090302	1/61	APC-Cdc20 complex activity	molecular_function	"A ubiquitin-protein ligase activity that increases the rate or extent of the metaphase to anaphase transition of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
EOG8TTJXP	GO:0004842	8/68	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8TTJXP	GO:0008270	1/68	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8M9461	GO:0050660	1/4	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8M9461	GO:0016614	1/4	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8TTJXX	GO:0008270	50/79	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TTJXX	GO:0008237	50/79	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8TTJXX	GO:0004177	6/79	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG8TTJXX	GO:0006508	2/79	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8HX7FC	GO:0005524	28/97	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8HX7FC	GO:0008026	27/97	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8HX7FC	GO:0003723	23/97	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8HX7FC	GO:0003676	5/97	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HX7FC	GO:0004386	1/97	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8HX7FC	GO:0005730	1/97	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG841STJ	GO:0006950	1/3	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG841STJ	GO:0008270	1/3	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83FK9T	GO:0033227	15/60	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG83FK9T	GO:0016021	15/60	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83FK9T	GO:0051033	15/60	RNA transmembrane transporter activity	molecular_function	"Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]
EOG83FK9T	GO:0005524	1/60	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG83FK9T	GO:0004674	1/60	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8S7N57	GO:0016559	21/64	peroxisome fission	biological_process	"The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507]
EOG8S7N57	GO:0005779	21/64	integral component of peroxisomal membrane	cellular_component	"The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah]
EOG8S7N57	GO:0007031	1/64	peroxisome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
EOG8HDW84	GO:0006629	11/69	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8HDW80	GO:0005634	9/49	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HDW80	GO:0003676	8/49	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HDW80	GO:0004535	1/49	poly(A)-specific ribonuclease activity	molecular_function	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]
EOG82FW10	GO:0003954	1/72	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8H1DC0	GO:0005272	2/4	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8H1DC0	GO:0016021	2/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8H1DC5	GO:0003700	2/8	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8H1DC5	GO:0043565	2/8	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8GMXBX	GO:0006542	1/4	glutamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
EOG8GMXBX	GO:0004356	1/4	glutamate-ammonia ligase activity	molecular_function	"Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.2, RHEA:16172]
EOG8CC6F9	GO:0043565	1/47	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8CC6F9	GO:0003700	1/47	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8RZ1HG	GO:0007050	3/31	cell cycle arrest	biological_process	"A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]
EOG8RZ1HG	GO:0004861	3/31	cyclin-dependent protein serine/threonine kinase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr]
EOG8RZ1HG	GO:0005634	3/31	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CC6F7	GO:0055085	36/143	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8CC6F7	GO:0016021	36/143	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BGCCB	GO:0000122	5/35	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8BGCCB	GO:0016567	5/35	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8BGCCB	GO:0008270	4/35	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BGCCB	GO:0043066	2/35	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8BGCCB	GO:0071157	2/35	negative regulation of cell cycle arrest	biological_process	"Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases." [GOC:mah]
EOG8BGCCB	GO:0016874	2/35	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8BGCCB	GO:0005634	2/35	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BGCCB	GO:0003676	1/35	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BZQGQ	GO:0003755	19/79	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8BZQGQ	GO:0006457	19/79	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8BZQGQ	GO:0008270	18/79	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BZQGQ	GO:0005622	14/79	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8HMMQN	GO:0005634	25/145	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HMMQN	GO:0005737	8/145	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HMMQN	GO:0030512	8/145	negative regulation of transforming growth factor beta receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway." [GOC:mah]
EOG8HMMQN	GO:0003714	8/145	transcription corepressor activity	molecular_function	"Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8HMMQN	GO:0003677	2/145	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8HMMQN	GO:0030514	2/145	negative regulation of BMP signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators]
EOG8HMMQN	GO:0000122	1/145	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8HMMQN	GO:0070410	1/145	co-SMAD binding	molecular_function	"Interacting selectively and non-covalently with a common mediator SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]
EOG8HMMQN	GO:0007474	1/145	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG8CC6FD	GO:0006355	25/87	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8CC6FD	GO:0005634	24/87	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CC6FD	GO:0032783	1/87	ELL-EAF complex	cellular_component	"A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae." [PMID:17150956]
EOG8CC6FD	GO:0005674	1/87	transcription factor TFIIF complex	cellular_component	"A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077]
EOG8CC6FD	GO:0005669	1/87	transcription factor TFIID complex	cellular_component	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]
EOG8CC6FD	GO:0006367	1/87	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG82Z74Q	GO:0005874	1/4	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG82Z74Q	GO:0005524	1/4	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82Z74Q	GO:0005871	1/4	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG82Z74Q	GO:0007018	1/4	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG82Z74Q	GO:0003777	1/4	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG82Z74P	GO:0008270	2/7	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG82Z74P	GO:0003676	2/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82Z74P	GO:0005634	1/7	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82Z74P	GO:0003964	1/7	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG82Z74P	GO:0046872	1/7	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82Z74P	GO:0003723	1/7	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CC6FC	GO:0005096	1/5	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8CC6FC	GO:0005622	1/5	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8CC6FC	GO:0007165	1/5	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG82Z74K	GO:0035556	6/20	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG82Z74K	GO:0004623	2/20	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG82Z74D	GO:0004930	9/63	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG82Z74D	GO:0016021	7/63	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82Z74D	GO:0006950	7/63	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG82Z74D	GO:0016020	1/63	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Q87DG	GO:0005525	22/78	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8Q87DG	GO:0005622	20/78	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8Q87DG	GO:0007264	20/78	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8Q87DG	GO:0046872	1/78	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Q87DG	GO:0020037	1/78	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8Q87DC	GO:0040007	9/56	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG8Q87DC	GO:0005576	3/56	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Z654F	GO:0008138	6/23	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG8Z654F	GO:0004725	6/23	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8HDW8S	GO:0004984	2/9	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8HDW8S	GO:0005549	2/9	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8HDW8S	GO:0004930	1/9	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8HDW8S	GO:0016021	1/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HDW8S	GO:0016020	1/9	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8N335D	GO:0005581	1/4	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8RNDS2	GO:0005525	26/112	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8RNDS2	GO:0007264	26/112	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8RNDS2	GO:0008060	23/112	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8RNDS2	GO:0032312	23/112	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8RNDS2	GO:0005622	23/112	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8RNDS2	GO:0008270	23/112	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RNDS2	GO:0016020	8/112	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RNDS2	GO:0006184	8/112	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8RNDS2	GO:0043547	1/112	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8HDW8F	GO:0006886	37/164	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8HDW8F	GO:0048193	24/164	Golgi vesicle transport	biological_process	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG8HDW8F	GO:0016020	23/164	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HDW8F	GO:0007269	2/164	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8HDW8F	GO:0042147	1/164	retrograde transport, endosome to Golgi	biological_process	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]
EOG8HDW8F	GO:0005886	1/164	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8HDW8F	GO:0016081	1/164	synaptic vesicle docking	biological_process	"The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342]
EOG8HDW8F	GO:0051726	1/164	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8HDW8F	GO:0016021	1/164	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HDW8F	GO:0006906	1/164	vesicle fusion	biological_process	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]
EOG8HDW8F	GO:0016082	1/164	synaptic vesicle priming	biological_process	"The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342]
EOG8HDW8F	GO:0005483	1/164	soluble NSF attachment protein activity	molecular_function	"Interacting selectively and non-covalently with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857]
EOG8HDW8F	GO:0016192	1/164	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8HDW8F	GO:0005737	1/164	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HDW8F	GO:0048190	1/164	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8HDW8F	GO:0005484	1/164	SNAP receptor activity	molecular_function	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
EOG8RNDS6	GO:0004129	4/72	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8RNDS6	GO:0005739	3/72	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG85F04G	GO:0005576	1/201	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG85F04G	GO:0046427	1/201	positive regulation of JAK-STAT cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG8H74V2	GO:0016020	1/106	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8H74V2	GO:0005024	1/106	transforming growth factor beta-activated receptor activity	molecular_function	"Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]
EOG85F04B	GO:0016491	4/25	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG85F04B	GO:0043565	1/25	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8N06V0	GO:0016747	9/36	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8N06V1	GO:0020037	1/69	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8N06V1	GO:0019825	1/69	oxygen binding	molecular_function	"Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl]
EOG85XB9Q	GO:0000166	27/96	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG85XB9Q	GO:0030529	27/96	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG85XB9Q	GO:0006396	27/96	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG85XB9Q	GO:0005634	27/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85XB9Q	GO:0003723	26/96	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG85XB9Q	GO:0003729	1/96	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG85XB9Q	GO:0003676	1/96	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85XB9Q	GO:0019013	1/96	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG85XB9Q	GO:0003677	1/96	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG85XB9Q	GO:0008098	1/96	5S rRNA primary transcript binding	molecular_function	"Interacting selectively and non-covalently with the unprocessed 5S ribosomal RNA transcript." [GOC:jl]
EOG8N06V7	GO:0003676	9/45	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8N06V7	GO:0015074	8/45	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8N06V7	GO:0003964	5/45	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8N06V7	GO:0003723	5/45	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8N06V7	GO:0008270	3/45	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8N06V7	GO:0004190	2/45	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8N06V7	GO:0003677	1/45	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8N06V7	GO:0006310	1/45	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG88GZK7	GO:0004252	3/7	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8P5NRT	GO:0008237	1/13	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8P5NRZ	GO:0006457	1/3	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG88GZKB	GO:0005576	2/5	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG89PDJ5	GO:0003964	1/12	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG89PDJ5	GO:0004519	1/12	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8P5NRC	GO:0003964	1/5	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8P5NRC	GO:0004519	1/5	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8P5NRB	GO:0008897	13/48	holo-[acyl-carrier-protein] synthase activity	molecular_function	"Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709]
EOG8P5NRB	GO:0000287	13/48	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8P5NRB	GO:0009059	13/48	macromolecule biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah]
EOG88GZKQ	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84TRQF	GO:0008270	2/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84TRQF	GO:0003676	2/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84TRQF	GO:0005634	2/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8JHFXC	GO:0004185	1/3	serine-type carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8SN43R	GO:0016021	2/63	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG815JTD	GO:0004970	151/510	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG815JTD	GO:0005234	151/510	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG815JTD	GO:0030054	151/510	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG815JTD	GO:0045211	149/510	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG815JTD	GO:0016021	148/510	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG815JTD	GO:0035235	8/510	ionotropic glutamate receptor signaling pathway	biological_process	"A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732]
EOG815JTD	GO:0034220	8/510	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG815JTD	GO:0015277	7/510	kainate selective glutamate receptor activity	molecular_function	"An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist." [GOC:mah, PMID:10049997, PMID:8804111]
EOG815JTD	GO:0030425	6/510	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG815JTD	GO:0008328	6/510	ionotropic glutamate receptor complex	cellular_component	"A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
EOG815JTD	GO:0035249	5/510	synaptic transmission, glutamatergic	biological_process	"The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv]
EOG815JTD	GO:0005886	3/510	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG815JTD	GO:0031594	3/510	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG815JTD	GO:1900073	2/510	regulation of neuromuscular synaptic transmission	biological_process	"Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
EOG815JTD	GO:0045202	2/510	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG815JTD	GO:0036081	2/510	extracellular ammonia-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
EOG815JTD	GO:0007274	2/510	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG815JTD	GO:0008066	1/510	glutamate receptor activity	molecular_function	"Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]
EOG815JTD	GO:0005215	1/510	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG815JTD	GO:0043179	1/510	rhythmic excitation	biological_process	"Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit." [GOC:go_curators, ISBN:0195088433]
EOG815JTD	GO:0051968	1/510	positive regulation of synaptic transmission, glutamatergic	biological_process	"Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
EOG815JTD	GO:0048812	1/510	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG815JTD	GO:0007268	1/510	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG815JTD	GO:0005509	1/510	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG815JTD	GO:0046928	1/510	regulation of neurotransmitter secretion	biological_process	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
EOG815JTD	GO:0097482	1/510	muscle cell postsynaptic density	cellular_component	"A postsynaptic density that is part of a muscle cell." [GOC:pr]
EOG815JTD	GO:1900075	1/510	positive regulation of neuromuscular synaptic transmission	biological_process	"Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
EOG815JTD	GO:0016020	1/510	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG815JTD	GO:0060025	1/510	regulation of synaptic activity	biological_process	"Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell." [GOC:dph, GOC:tb]
EOG8J9QFP	GO:0003676	15/55	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8J9QFP	GO:0006457	1/55	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8J9QFP	GO:0016272	1/55	prefoldin complex	cellular_component	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]
EOG8JHFXX	GO:0008270	18/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG86HJRD	GO:0006979	4/13	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG86HJRD	GO:0020037	4/13	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG86HJRD	GO:0004096	4/13	catalase activity	molecular_function	"Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6]
EOG8FTZH1	GO:0005739	1/45	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8FTZH1	GO:0008137	1/45	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8HHRK7	GO:0043565	6/42	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8HHRK7	GO:0005634	6/42	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HHRK7	GO:0003700	6/42	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8CVJQ0	GO:0005581	1/6	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG837TTP	GO:0005622	25/119	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG837TTP	GO:0005525	21/119	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG837TTP	GO:0007264	20/119	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG837TTP	GO:0007165	7/119	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG837TTP	GO:0032321	1/119	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG837TTP	GO:0005100	1/119	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG837TTP	GO:0007415	1/119	defasciculation of motor neuron axon	biological_process	"Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh]
EOG837TTP	GO:0016319	1/119	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG837TTP	GO:0007266	1/119	Rho protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf]
EOG837TTP	GO:0050770	1/119	regulation of axonogenesis	biological_process	"Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]
EOG837TTP	GO:0045792	1/119	negative regulation of cell size	biological_process	"Any process that reduces cell size." [GOC:go_curators]
EOG837TTP	GO:0030215	1/119	semaphorin receptor binding	molecular_function	"Interacting selectively and non-covalently with semaphorin receptors." [GOC:ceb, PMID:12001990]
EOG837TTQ	GO:0004842	32/106	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG837TTQ	GO:0008270	20/106	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG837TTQ	GO:0005886	1/106	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG837TTQ	GO:0030509	1/106	BMP signaling pathway	biological_process	"A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PR:000000034]
EOG837TTQ	GO:0004252	1/106	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG837TTQ	GO:0040011	1/106	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG837TTQ	GO:0005634	1/106	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG837TTQ	GO:0005515	1/106	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG837TTQ	GO:0007628	1/106	adult walking behavior	biological_process	"The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907]
EOG837TTQ	GO:0016567	1/106	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG837TTQ	GO:0006914	1/106	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG837TTQ	GO:0016023	1/106	cytoplasmic membrane-bounded vesicle	cellular_component	"A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
EOG837TTQ	GO:0045886	1/106	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG837TTQ	GO:2000331	1/106	regulation of terminal button organization	biological_process	"Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah]
EOG837TTQ	GO:0008582	1/106	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG837TTQ	GO:0050808	1/106	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG837TTQ	GO:0006351	1/106	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG837TTQ	GO:0030514	1/106	negative regulation of BMP signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators]
EOG86HJRZ	GO:0016020	1/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG86HJRZ	GO:0006814	1/5	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG86HJRZ	GO:0055085	1/5	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG86HJRZ	GO:0005215	1/5	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8RV55H	GO:0005089	26/99	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8RV55H	GO:0035556	7/99	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8RV55H	GO:0046872	6/99	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8BGC9P	GO:0000079	16/111	regulation of cyclin-dependent protein serine/threonine kinase activity	biological_process	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]
EOG8BGC9P	GO:0005634	15/111	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BGC9P	GO:0007049	14/111	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG8BGC9P	GO:0051301	14/111	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8BGC9P	GO:0003950	6/111	NAD+ ADP-ribosyltransferase activity	molecular_function	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]
EOG8BGC9P	GO:0016787	2/111	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8S4RW1	GO:0016021	8/16	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S4RW1	GO:0015299	8/16	solute:proton antiporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]
EOG8S4RW1	GO:0005216	1/16	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG844P0P	GO:0008270	5/33	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83XXJC	GO:0016740	3/372	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG83XXJC	GO:0005634	1/372	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83XXJC	GO:0008168	1/372	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG83XXJC	GO:0008270	1/372	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83XXJC	GO:0022008	1/372	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG83XXJC	GO:0005737	1/372	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8BGC9X	GO:0016021	2/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BGC9X	GO:0055085	2/6	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8BGC9X	GO:0005737	1/6	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8BGC9X	GO:0044208	1/6	'de novo' AMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP)." [GOC:ecd, PMID:10888601]
EOG8BGC9X	GO:0004019	1/6	adenylosuccinate synthase activity	molecular_function	"Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate." [EC:6.3.4.4, RHEA:15756]
EOG8BGC9X	GO:0005525	1/6	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8BGC9X	GO:0000287	1/6	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG879HMZ	GO:0016772	69/190	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG879HMZ	GO:0016301	11/190	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG879HMZ	GO:0017022	1/190	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG879HMZ	GO:0022008	1/190	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG85HVBJ	GO:0016020	2/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RJJGR	GO:0003677	2/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG83XXJW	GO:0016787	19/49	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG83XXJW	GO:0008967	1/49	phosphoglycolate phosphatase activity	molecular_function	"Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate." [EC:3.1.3.18, RHEA:14372]
EOG8BGC90	GO:0008270	1/53	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BGC90	GO:0003676	1/53	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG870WZ1	GO:0016021	2/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG870WZ1	GO:0022857	1/6	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG870WZ1	GO:0055085	1/6	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8CNT5F	GO:0016020	2/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8GTNTG	GO:0005215	2/5	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8GTNTG	GO:0016020	2/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CNT5N	GO:0016773	22/99	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8CNT5N	GO:0016301	3/99	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8CNT5N	GO:0005524	2/99	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CNT5N	GO:0005802	1/99	trans-Golgi network	cellular_component	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]
EOG8CNT5N	GO:0032252	1/99	secretory granule localization	biological_process	"Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah]
EOG8CNT5N	GO:0005770	1/99	late endosome	cellular_component	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
EOG8CNT5N	GO:0046854	1/99	phosphatidylinositol phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]
EOG8CNT5N	GO:0004430	1/99	1-phosphatidylinositol 4-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.67, RHEA:19880]
EOG8CNT5N	GO:0007030	1/99	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8CNT5W	GO:0030060	17/34	L-malate dehydrogenase activity	molecular_function	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]
EOG8CNT5W	GO:0006108	17/34	malate metabolic process	biological_process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]
EOG8CNT5W	GO:0044262	17/34	cellular carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
EOG8CNT5W	GO:0006099	3/34	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8CNT5W	GO:0005811	1/34	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8CNT5W	GO:0005739	1/34	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8CNT5W	GO:0035070	1/34	salivary gland histolysis	biological_process	"The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683]
EOG8CNT5W	GO:0035209	1/34	pupal development	biological_process	"The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis." [GOC:bf, GOC:mtg_sensu]
EOG8CNT5W	GO:0043068	1/34	positive regulation of programmed cell death	biological_process	"Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
EOG8CNT5W	GO:0043067	1/34	regulation of programmed cell death	biological_process	"Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
EOG8CNT5W	GO:0016615	1/34	malate dehydrogenase activity	molecular_function	"Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]
EOG8CNT5W	GO:0006919	1/34	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
EOG8S4RWK	GO:0016798	25/117	hydrolase activity, acting on glycosyl bonds	molecular_function	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]
EOG8S4RWK	GO:0016020	25/117	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8S4RWK	GO:0005975	4/117	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8S4RWK	GO:0015991	2/117	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8S4RWK	GO:0015078	2/117	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG8S4RWK	GO:0033179	2/117	proton-transporting V-type ATPase, V0 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG8S4RWK	GO:0005811	1/117	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG83XXJ5	GO:0006511	23/108	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG83XXJ5	GO:0008234	16/108	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG83XXJ5	GO:0004221	2/108	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG83XXJ5	GO:0045880	1/108	positive regulation of smoothened signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG83XXJ5	GO:0016579	1/108	protein deubiquitination	biological_process	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]
EOG83XXJ5	GO:0008587	1/108	imaginal disc-derived wing margin morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG83XXJ5	GO:0090263	1/108	positive regulation of canonical Wnt signaling pathway	biological_process	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]
EOG83XXJ5	GO:0005737	1/108	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83XXJ5	GO:0004843	1/108	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG8QJV4S	GO:0042302	18/47	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8QJV4S	GO:0008010	1/47	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8QJV4S	GO:0032504	1/47	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8QJV4S	GO:0031012	1/47	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8QJV4S	GO:0040003	1/47	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8QJV4S	GO:0005615	1/47	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8QJV4Q	GO:0005921	1/3	gap junction	cellular_component	"A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181]
EOG8QJV4Q	GO:0006811	1/3	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8JT2PV	GO:0030145	1/3	manganese ion binding	molecular_function	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
EOG8JT2PV	GO:0000287	1/3	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8JT2PV	GO:0004721	1/3	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8R7XR3	GO:0055085	46/146	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8R7XR3	GO:0016021	46/146	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M67XG	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8M67XG	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M67XG	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8M67XD	GO:0008270	4/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG898XGH	GO:0016740	2/7	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG898XGH	GO:0006633	2/7	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG898XGH	GO:0016021	2/7	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JDKMP	GO:0004622	1/67	lysophospholipase activity	molecular_function	"Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5]
EOG8JDKMP	GO:0048812	1/67	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8P5NQ2	GO:0008080	27/104	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG8P5NQ2	GO:0006355	1/104	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8P5NQ2	GO:0006351	1/104	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8P5NQ2	GO:0005634	1/104	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8P5NQ2	GO:0005524	1/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8P5NQ2	GO:0022008	1/104	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG886BVT	GO:0007274	1/81	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG886BVT	GO:0031083	1/81	BLOC-1 complex	cellular_component	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]
EOG886BVT	GO:0005515	1/81	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG886BVT	GO:0008057	1/81	eye pigment granule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295]
EOG8PP10G	GO:0003824	1/42	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8PP10B	GO:0042302	14/26	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8PP10B	GO:0040003	1/26	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8PP10B	GO:0031012	1/26	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8PP10B	GO:0008010	1/26	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8G4K5P	GO:0032926	1/81	negative regulation of activin receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl]
EOG8G4K5P	GO:0032927	1/81	positive regulation of activin receptor signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl]
EOG8G4K5P	GO:0090099	1/81	negative regulation of decapentaplegic signaling pathway	biological_process	"Any process that decreases the frequency, rate, or extent of the decapentaplegic signaling pathway. The decapentaplegic signaling pathway is the series of molecular signals generated as a consequence of the signal decapentaplegic binding to one of its physiological receptors." [GOC:dph, GOC:tb]
EOG8G4K5P	GO:0005576	1/81	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8PP10H	GO:0008270	1/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GQSKG	GO:0004984	29/55	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8GQSKG	GO:0016021	29/55	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GQSKG	GO:0005549	29/55	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8GQSKG	GO:0004930	28/55	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8GQSKG	GO:0005886	26/55	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8GQSKG	GO:0050911	1/55	detection of chemical stimulus involved in sensory perception of smell	biological_process	"The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8GQSKG	GO:0016020	1/55	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8GQSKG	GO:0050909	1/55	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8HTC6F	GO:0016021	21/85	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HTC6F	GO:0055085	14/85	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8HTC6F	GO:0015114	7/85	phosphate ion transmembrane transporter activity	molecular_function	"Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai]
EOG898XG5	GO:0006813	1/3	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG898XG5	GO:0005890	1/3	sodium:potassium-exchanging ATPase complex	cellular_component	"Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732]
EOG898XG5	GO:0006814	1/3	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG87M4F7	GO:0000166	2/5	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG87M4F7	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG87M4F8	GO:0046872	7/47	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG87M4F8	GO:0003676	6/47	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CRPGB	GO:0004792	13/104	thiosulfate sulfurtransferase activity	molecular_function	"Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate." [EC:2.8.1.1, RHEA:16884]
EOG8CRPGB	GO:0006950	2/104	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG87SVTQ	GO:0004519	1/49	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8X6FQM	GO:0051920	68/238	peroxiredoxin activity	molecular_function	"Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." [EC:1.11.1.15]
EOG8X6FQM	GO:0016209	57/238	antioxidant activity	molecular_function	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
EOG8X6FQM	GO:0004601	11/238	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG8X6FQM	GO:0042744	3/238	hydrogen peroxide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]
EOG8X6FQM	GO:0008379	3/238	thioredoxin peroxidase activity	molecular_function	"Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O." [MetaCyc:RXN0-267]
EOG8X6FQM	GO:0045454	2/238	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8X6FQM	GO:0006974	2/238	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8X6FQM	GO:0005829	2/238	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8X6FQM	GO:0005515	2/238	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8X6FQM	GO:0008340	2/238	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8X6FQM	GO:0008354	1/238	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8X6FQM	GO:0005576	1/238	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8X6FQM	GO:0007281	1/238	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8X6FQM	GO:0007155	1/238	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8X6FQM	GO:0043066	1/238	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8X6FQM	GO:0005875	1/238	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8X6FQM	GO:0042594	1/238	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8X6FQM	GO:0005783	1/238	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8X6FQM	GO:0006979	1/238	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8X6FQM	GO:0006909	1/238	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8X6FQM	GO:0005739	1/238	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8X6FQM	GO:0097190	1/238	apoptotic signaling pathway	biological_process	"A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]
EOG82Z75C	GO:0003700	35/139	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG82Z75C	GO:0005634	35/139	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82Z75C	GO:0043565	30/139	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG82Z75C	GO:0000976	5/139	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG82Z75C	GO:0004000	2/139	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG82Z75C	GO:0007389	1/139	pattern specification process	biological_process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
EOG82Z75C	GO:0007485	1/139	imaginal disc-derived male genitalia development	biological_process	"The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
EOG82Z75C	GO:0007398	1/139	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG82Z75C	GO:0007450	1/139	dorsal/ventral pattern formation, imaginal disc	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238]
EOG82Z75C	GO:0007517	1/139	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG82Z75C	GO:0035309	1/139	wing and notum subfield formation	biological_process	"The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999]
EOG82Z75C	GO:0009953	1/139	dorsal/ventral pattern formation	biological_process	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG82Z75C	GO:0010629	1/139	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG82Z75C	GO:0042659	1/139	regulation of cell fate specification	biological_process	"Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators]
EOG82Z75C	GO:0006355	1/139	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82Z75C	GO:0007420	1/139	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG82Z75C	GO:0007419	1/139	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG82Z75C	GO:0021782	1/139	glial cell development	biological_process	"The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG82Z75C	GO:0007476	1/139	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG82Z75C	GO:0035222	1/139	wing disc pattern formation	biological_process	"The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf]
EOG82Z75C	GO:0007400	1/139	neuroblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
EOG82Z75C	GO:0007417	1/139	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8ZCWMM	GO:0005272	2/5	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8ZCWMM	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZCWMM	GO:0016020	1/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HDW9T	GO:0004222	3/6	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8HDW9T	GO:0008270	1/6	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8HDW9S	GO:0004252	1/3	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8GB9M6	GO:0003676	17/52	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GB9M6	GO:0046872	17/52	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GB9M6	GO:0005634	2/52	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GB9M6	GO:0003677	1/52	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GB9M6	GO:0006351	1/52	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8GB9M6	GO:0006355	1/52	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8GB9M6	GO:0007275	1/52	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8GB9M6	GO:0008270	1/52	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8HDW9G	GO:0005741	2/4	mitochondrial outer membrane	cellular_component	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
EOG8HDW9G	GO:0033554	2/4	cellular response to stress	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8C2KS3	GO:0015986	37/111	ATP synthesis coupled proton transport	biological_process	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]
EOG8C2KS3	GO:0000276	37/111	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	cellular_component	"All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056]
EOG8C2KS3	GO:0015078	36/111	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG8C2KS3	GO:0016787	2/111	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8C2KS3	GO:0006909	1/111	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8C2KS3	GO:0046933	1/111	proton-transporting ATP synthase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]
EOG8C2KS3	GO:0005811	1/111	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8TQPS7	GO:0006950	1/6	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8C2KSK	GO:0008270	2/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8C2KSK	GO:0003676	2/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8C2KSK	GO:0005634	2/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XSP6J	GO:0006950	1/3	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8GB9MT	GO:0005643	2/7	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG8S7N5X	GO:0005272	2/5	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8S7N5X	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z6553	GO:0006334	3/5	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8Z6553	GO:0003677	3/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Z6553	GO:0000786	3/5	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8Z6553	GO:0005634	3/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8DZ4BB	GO:0008270	5/22	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DZ4BB	GO:0003723	5/22	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8M945C	GO:0044267	23/106	cellular protein metabolic process	biological_process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]
EOG8M945C	GO:0005524	23/106	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8M945C	GO:0016307	20/106	phosphatidylinositol phosphate kinase activity	molecular_function	"Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495]
EOG8M945C	GO:0046872	19/106	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8M945C	GO:0035556	18/106	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8M945C	GO:0000285	3/106	1-phosphatidylinositol-3-phosphate 5-kinase activity	molecular_function	"Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13612]
EOG8M945C	GO:0005768	1/106	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG8M945C	GO:0000046	1/106	autophagosome maturation	biological_process	"The process in which autophagosomes, double-membraned vacuoles containing cytoplasmic material fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [GOC:autophagy, GOC:lf, PMID:11099404, PMID:16874026, PMID:17534139]
EOG8M945C	GO:0016308	1/106	1-phosphatidylinositol-4-phosphate 5-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.68, RHEA:14428]
EOG8M945C	GO:0010008	1/106	endosome membrane	cellular_component	"The lipid bilayer surrounding an endosome." [GOC:mah]
EOG8M945C	GO:0008333	1/106	endosome to lysosome transport	biological_process	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]
EOG8M945C	GO:0046854	1/106	phosphatidylinositol phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]
EOG8M945C	GO:0016310	1/106	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG8M945C	GO:0008270	1/106	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8M945C	GO:0012506	1/106	vesicle membrane	cellular_component	"The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah]
EOG82Z752	GO:0003676	2/18	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82Z752	GO:0008270	1/18	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG82Z752	GO:0046872	1/18	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82Z752	GO:0006351	1/18	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG82Z752	GO:0003677	1/18	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG82Z752	GO:0003899	1/18	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8X6FQ7	GO:0005634	2/6	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X6FQ7	GO:0008270	2/6	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X6FQ7	GO:0003676	2/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X6FQ1	GO:0016706	21/81	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG8CRPG7	GO:0046872	2/7	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CRPG7	GO:0003676	2/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DZ4BQ	GO:0030127	1/4	COPII vesicle coat	cellular_component	"One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]
EOG8DZ4BQ	GO:0006888	1/4	ER to Golgi vesicle-mediated transport	biological_process	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]
EOG8DZ4BQ	GO:0006886	1/4	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG83R63D	GO:0016021	2/7	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M945W	GO:0016021	23/88	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M945W	GO:0008324	22/88	cation transmembrane transporter activity	molecular_function	"Enables the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
EOG8M945W	GO:0005886	1/88	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8M945W	GO:0005622	1/88	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8M945W	GO:0022883	1/88	zinc efflux transmembrane transporter activity	molecular_function	"Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
EOG8M945W	GO:0071577	1/88	zinc II ion transmembrane transport	biological_process	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]
EOG8M945W	GO:0016323	1/88	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG8M945T	GO:0016021	82/190	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M945T	GO:0022857	58/190	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8M945T	GO:0055085	24/190	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8M945T	GO:0005215	10/190	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8P5NSB	GO:0005886	1/103	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8P5NSB	GO:0043195	1/103	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG8P5NSB	GO:0007270	1/103	neuron-neuron synaptic transmission	biological_process	"The process of communication from a neuron to another neuron across a synapse." [GOC:add, GOC:jl, MeSH:D009435]
EOG8P5NSB	GO:0007274	1/103	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8P5NSB	GO:0070073	1/103	clustering of voltage-gated calcium channels	biological_process	"The process in which voltage-gated calcium channels become localized together in high densities." [GOC:BHF, GOC:sart, PMID:18385325]
EOG8P5NSB	GO:0042734	1/103	presynaptic membrane	cellular_component	"A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194]
EOG8SFCMT	GO:0016021	8/49	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SFCMT	GO:0022857	6/49	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8SFCMT	GO:0005215	2/49	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8SFCMT	GO:0055085	2/49	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8TB6TR	GO:0005886	2/9	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8TB6TR	GO:0016021	2/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TB6TR	GO:0050909	2/9	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8P5NSH	GO:0003677	1/24	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8P5NSH	GO:0043565	1/24	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8P5NSH	GO:0003700	1/24	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8TB6TQ	GO:0005549	4/11	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG88D3C5	GO:0016021	2/13	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8P2SHF	GO:0005874	2/6	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8P2SHF	GO:0016021	2/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8P2SHF	GO:0005272	2/6	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8P2SHF	GO:0000226	2/6	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG85QKTN	GO:0003950	1/59	NAD+ ADP-ribosyltransferase activity	molecular_function	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]
EOG8KM1H1	GO:0008270	2/7	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KM1H1	GO:0008237	2/7	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8KM1H1	GO:0004177	1/7	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG8RNDR2	GO:0016301	1/30	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8RNDRX	GO:0016020	1/18	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8KM1HS	GO:0006629	3/10	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8KM1HS	GO:0006071	3/10	glycerol metabolic process	biological_process	"The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]
EOG8KM1HS	GO:0008889	3/10	glycerophosphodiester phosphodiesterase activity	molecular_function	"Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]
EOG82C0Q1	GO:0072487	1/5	MSL complex	cellular_component	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852]
EOG82C0Q1	GO:0043984	1/5	histone H4-K16 acetylation	biological_process	"The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone." [GOC:jl]
EOG8MGVQF	GO:0008270	2/6	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8JQ6BS	GO:0006869	1/4	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG8TB6T7	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8TB6T7	GO:0000166	2/5	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8CZDXB	GO:0005975	21/49	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8CZDXB	GO:0016757	18/49	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8CZDXB	GO:0003945	2/49	N-acetyllactosamine synthase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90]
EOG8CZDXB	GO:0005794	1/49	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8CZDXB	GO:0033842	1/49	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244]
EOG8CZDXB	GO:0009247	1/49	glycolipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators]
EOG8CZDXB	GO:0008376	1/49	acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]
EOG8CZDXB	GO:0006044	1/49	N-acetylglucosamine metabolic process	biological_process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
EOG8PCD80	GO:0003964	2/12	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8PCD80	GO:0003723	1/12	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8FXTNP	GO:0005234	3/6	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8FXTNP	GO:0045211	3/6	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8FXTNP	GO:0016021	3/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FXTNP	GO:0030054	3/6	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8FXTNP	GO:0004970	3/6	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8PCD88	GO:0006886	27/100	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8PCD88	GO:0016021	27/100	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PCD88	GO:0005783	27/100	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8DZ492	GO:0016620	2/4	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG8RZ1H3	GO:0003964	1/7	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8RZ1H3	GO:0003824	1/7	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8RZ1H3	GO:0004519	1/7	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8BZQJ5	GO:0004252	2/5	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG85F05F	GO:0008289	41/142	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG85F05F	GO:0005215	41/142	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG85F05F	GO:0005875	1/142	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG85F05F	GO:0007616	1/142	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8DZ49B	GO:0016301	2/112	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8DZ49B	GO:0046872	1/112	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DZ49B	GO:0036090	1/112	cleavage furrow ingression	biological_process	"Advancement of the cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed." [PMID:15811947, PMID:20687468]
EOG8DZ49B	GO:0071212	1/112	subsynaptic reticulum	cellular_component	"An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:1460464, PMID:18171947, PMID:19244343, PMID:7946331]
EOG8DZ49B	GO:0005543	1/112	phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8DZ49B	GO:0007269	1/112	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8DZ49B	GO:0045211	1/112	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8DZ49B	GO:0061024	1/112	membrane organization	biological_process	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]
EOG8DZ49B	GO:0003677	1/112	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DZ49B	GO:0007112	1/112	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG8DZ49B	GO:0006355	1/112	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8DZ49B	GO:0030496	1/112	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG8DZ49B	GO:0048488	1/112	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8DZ49B	GO:0005886	1/112	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8DZ49B	GO:0032154	1/112	cleavage furrow	cellular_component	"In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409]
EOG8DZ49B	GO:0007053	1/112	spindle assembly involved in male meiosis	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah]
EOG8DZ49B	GO:0008289	1/112	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG8DZ49B	GO:0045887	1/112	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8DZ49B	GO:0000281	1/112	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8DZ49B	GO:0005515	1/112	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8DZ49B	GO:0005634	1/112	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8N5ZBJ	GO:0035859	1/94	Seh1-associated complex	cellular_component	"A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883, PMID:23974112]
EOG8N5ZBJ	GO:0048813	1/94	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8PCD8D	GO:0008270	25/85	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PCD8D	GO:0003677	1/85	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8PCD8D	GO:0016604	1/85	nuclear body	cellular_component	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]
EOG8WM77Z	GO:0008236	2/17	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8WM77Z	GO:0016020	2/17	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Q5C4Z	GO:0008270	29/245	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q5C4Z	GO:0003676	26/245	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q5C4Z	GO:0003964	4/245	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8Q5C4Z	GO:0003723	4/245	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG85HVC8	GO:0046872	24/62	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85HVC8	GO:0003676	22/62	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85HVC8	GO:0000166	1/62	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG85HVC8	GO:0005097	1/62	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8Q5C4T	GO:0003993	9/17	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG8Q5C4K	GO:0020037	3/7	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8Q5C4K	GO:0016705	3/7	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8Q5C4K	GO:0005506	3/7	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8Q5C4K	GO:0004497	3/7	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG88SK94	GO:0016021	2/47	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G4K4B	GO:0005615	7/55	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8G4K4B	GO:0004866	7/55	endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl]
EOG8BP3RX	GO:0016020	2/6	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8BP3RZ	GO:0005524	28/93	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8BP3RZ	GO:0016887	27/93	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8BP3RZ	GO:0015439	1/93	heme-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [EC:3.6.3.41]
EOG847J9S	GO:0016301	1/25	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8ZPH90	GO:0030534	1/94	adult behavior	biological_process	"Behavior in a fully developed and mature organism." [GOC:mah, ISBN:0877797099]
EOG8ZPH90	GO:0045471	1/94	response to ethanol	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators]
EOG8ZPH90	GO:0040012	1/94	regulation of locomotion	biological_process	"Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems]
EOG8ZPH90	GO:0030425	1/94	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8ZPH90	GO:0048149	1/94	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8ZPH90	GO:0045938	1/94	positive regulation of circadian sleep/wake cycle, sleep	biological_process	"Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators]
EOG8ZPH90	GO:0005783	1/94	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8ZPH90	GO:0005515	1/94	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8R7XSD	GO:0003954	1/95	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8R7XSD	GO:0008137	1/95	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8F7R0G	GO:0035091	8/45	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG8ZPH9B	GO:0046961	1/5	proton-transporting ATPase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]
EOG8ZPH9B	GO:0033180	1/5	proton-transporting V-type ATPase, V1 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG8ZPH9B	GO:0046933	1/5	proton-transporting ATP synthase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]
EOG8ZPH9B	GO:0015991	1/5	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG847J92	GO:0004252	2/5	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8ZPH9R	GO:0031418	19/61	L-ascorbic acid binding	molecular_function	"Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]
EOG8ZPH9R	GO:0005506	19/61	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8ZPH9R	GO:0016706	18/61	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG8ZPH9R	GO:0018126	1/61	protein hydroxylation	biological_process	"The addition of a hydroxy group to a protein amino acid." [GOC:ai]
EOG8ZPH9R	GO:0016491	1/61	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8ZPH9R	GO:0042765	1/61	GPI-anchor transamidase complex	cellular_component	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]
EOG8ZPH9R	GO:0016255	1/61	attachment of GPI anchor to protein	biological_process	"A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595]
EOG8ZPH9R	GO:0031543	1/61	peptidyl-proline dioxygenase activity	molecular_function	"Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]
EOG8ZPH9R	GO:0005634	1/61	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZPH9R	GO:0006417	1/61	regulation of translation	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8ZPH9R	GO:0019511	1/61	peptidyl-proline hydroxylation	biological_process	"The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline." [GOC:mah]
EOG8ZPH9R	GO:0005737	1/61	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8F7R0S	GO:0016787	1/4	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8BGC8V	GO:0005634	6/54	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BGC8V	GO:0008270	6/54	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BGC8W	GO:0006744	3/22	ubiquinone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]
EOG83XXKJ	GO:0016740	1/3	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG87Q0KW	GO:0055085	6/56	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG87Q0KW	GO:0016021	6/56	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87Q0KW	GO:0008270	1/56	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87Q0KW	GO:0004181	1/56	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG8Q5C47	GO:0003964	34/377	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8Q5C47	GO:0003723	27/377	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8Q5C47	GO:0046872	14/377	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Q5C47	GO:0003677	7/377	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Q5C47	GO:0008270	3/377	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q5C47	GO:0003676	2/377	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q5C47	GO:0006355	2/377	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Q5C47	GO:0004519	1/377	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG88SK9S	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81G5J0	GO:0005524	23/96	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG81G5J0	GO:0004674	18/96	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG81G5J0	GO:0017111	6/96	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG81G5J0	GO:0005634	5/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81G5J0	GO:0008270	5/96	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81G5J0	GO:0003700	5/96	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8RJJFT	GO:0016021	16/63	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RJJFT	GO:0022891	15/63	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8RJJFT	GO:0008643	5/63	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8RJJFT	GO:0003964	1/63	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8RJJFT	GO:0046872	1/63	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RJJFT	GO:0003723	1/63	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RJJFT	GO:0022857	1/63	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8VX4MH	GO:0046872	1/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81G5J9	GO:0046872	2/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81G5J9	GO:0003676	1/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8C2KRG	GO:0003676	2/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8C2KRG	GO:0046872	2/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XPSXT	GO:0016021	33/98	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WDGTR	GO:0006813	1/3	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8WDGTR	GO:0005890	1/3	sodium:potassium-exchanging ATPase complex	cellular_component	"Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732]
EOG8WDGTR	GO:0006814	1/3	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG81K1T5	GO:0051287	73/226	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG81K1T5	GO:0016616	67/226	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG81K1T5	GO:0030267	4/226	glyoxylate reductase (NADP) activity	molecular_function	"Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [EC:1.1.1.79]
EOG81K1T5	GO:0047964	2/226	glyoxylate reductase activity	molecular_function	"Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH." [EC:1.1.1.26, MetaCyc:GLYCOLATE-REDUCTASE-RXN]
EOG81K1T5	GO:0004617	1/226	phosphoglycerate dehydrogenase activity	molecular_function	"Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95]
EOG81K1T5	GO:0005576	1/226	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG81K1T5	GO:0048037	1/226	cofactor binding	molecular_function	"Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]
EOG81K1T5	GO:0003676	1/226	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG81K1T2	GO:0005811	1/23	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG880MBT	GO:0005975	2/5	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG880MBT	GO:0004553	1/5	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG81K1T9	GO:0003677	16/116	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81K1T9	GO:0006355	10/116	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG81K1T9	GO:0006351	9/116	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG81K1T9	GO:0051493	9/116	regulation of cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
EOG81K1T9	GO:0007366	9/116	periodic partitioning by pair rule gene	biological_process	"Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG81K1T9	GO:0032368	9/116	regulation of lipid transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG81K1T9	GO:0008361	9/116	regulation of cell size	biological_process	"Any process that modulates the size of a cell." [GOC:go_curators]
EOG81K1T9	GO:0042051	9/116	compound eye photoreceptor development	biological_process	"The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
EOG81K1T9	GO:0003700	9/116	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG81K1T9	GO:0005634	9/116	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81K1T9	GO:0007365	1/116	periodic partitioning	biological_process	"The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma]
EOG81K1T9	GO:0007611	1/116	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG81K1T9	GO:0048190	1/116	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG81K1T9	GO:0000915	1/116	actomyosin contractile ring assembly	biological_process	"The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
EOG81K1T9	GO:0032783	1/116	ELL-EAF complex	cellular_component	"A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae." [PMID:17150956]
EOG81K1T9	GO:0007379	1/116	segment specification	biological_process	"The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG81K1T9	GO:0042048	1/116	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG8NP9H9	GO:0003676	3/51	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NP9H9	GO:0004523	2/51	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8NP9H9	GO:0008270	1/51	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG85QKSZ	GO:0005509	4/26	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG880MBN	GO:0051726	2/5	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8NP9HM	GO:0006904	24/108	vesicle docking involved in exocytosis	biological_process	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]
EOG8NP9HM	GO:0016020	2/108	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NP9HM	GO:0005737	2/108	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8NP9HM	GO:0016192	1/108	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8NP9HM	GO:0000149	1/108	SNARE binding	molecular_function	"Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]
EOG8NP9HM	GO:0006909	1/108	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8NP9HM	GO:0048190	1/108	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8NP9HM	GO:0022008	1/108	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8NP9HM	GO:0000902	1/108	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG880MB6	GO:0016021	25/107	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG880MB6	GO:0004930	22/107	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG880MB6	GO:0004715	3/107	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG880MB6	GO:0004952	3/107	dopamine neurotransmitter receptor activity	molecular_function	"Combining with the neurotransmitter dopamine to initiate a change in cell activity." [IUPHAR_GPCR:1282]
EOG880MB6	GO:0005887	3/107	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG880MB6	GO:0004977	2/107	melanocortin receptor activity	molecular_function	"Combining with melanocortin to initiate a change in cell activity." [GOC:ai]
EOG880MB6	GO:0007186	1/107	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG880MB6	GO:0007212	1/107	dopamine receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:mah]
EOG880MB6	GO:0004935	1/107	adrenergic receptor activity	molecular_function	"Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274]
EOG880MB6	GO:0008227	1/107	G-protein coupled amine receptor activity	molecular_function	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
EOG8NP9HG	GO:0005524	12/81	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8NP9HG	GO:0003676	12/81	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NP9HG	GO:0008026	12/81	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8NP9HG	GO:0046872	2/81	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NP9HG	GO:0031047	1/81	gene silencing by RNA	biological_process	"Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054]
EOG8NP9HG	GO:0031965	1/81	nuclear membrane	cellular_component	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
EOG8NP9HG	GO:0005694	1/81	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8NP9HG	GO:0030154	1/81	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8NP9HG	GO:0007275	1/81	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8NP9HG	GO:0007283	1/81	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8NP9HG	GO:0005829	1/81	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8NP9HG	GO:0007126	1/81	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8NP9HG	GO:0043186	1/81	P granule	cellular_component	"A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
EOG8GF5V1	GO:0005083	2/5	GTPase regulator activity	molecular_function	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
EOG8GF5V1	GO:0016301	1/5	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8GF5V1	GO:0004674	1/5	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8GF5V1	GO:0005524	1/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8GF5V5	GO:0022900	35/131	electron transport chain	biological_process	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport]
EOG8GF5V5	GO:0006099	35/131	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8GF5V5	GO:0050660	35/131	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8GF5V5	GO:0016627	31/131	oxidoreductase activity, acting on the CH-CH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8GF5V5	GO:0016491	5/131	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8GF5V5	GO:0008177	4/131	succinate dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol." [EC:1.3.5.1, RHEA:13716]
EOG8GF5V5	GO:0005743	1/131	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8GF5V5	GO:0005739	1/131	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8QJV5J	GO:0016021	23/129	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QJV5J	GO:0004965	22/129	G-protein coupled GABA receptor activity	molecular_function	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor]
EOG8QJV5J	GO:0007186	1/129	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8B5RMG	GO:0015232	2/38	heme transporter activity	molecular_function	"Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells." [GOC:ai]
EOG8CJZ0M	GO:0007275	7/34	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8CJZ0M	GO:0016021	7/34	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CJZ0M	GO:0007219	7/34	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG80CKWR	GO:0007264	55/204	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG80CKWR	GO:0005085	53/204	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG80CKWR	GO:0007417	2/204	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG80CKWR	GO:0032863	2/204	activation of GTPase activity	biological_process	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]
EOG80CKWR	GO:0005737	2/204	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG80CKWR	GO:0030036	1/204	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG80CKWR	GO:0005089	1/204	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG80CKWR	GO:0007391	1/204	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG80CKWR	GO:0007523	1/204	larval visceral muscle development	biological_process	"The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid]
EOG80CKWR	GO:0001726	1/204	ruffle	cellular_component	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]
EOG80CKWR	GO:0035212	1/204	cell competition in a multicellular organism	biological_process	"Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286]
EOG80CKWR	GO:0007298	1/204	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG80CKWR	GO:0030676	1/204	Rac guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG80CKWR	GO:0016203	1/204	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG80CKWR	GO:0045466	1/204	R7 cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339]
EOG80CKWR	GO:0007519	1/204	skeletal muscle tissue development	biological_process	"The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
EOG80CKWR	GO:0005515	1/204	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG80CKWR	GO:0007010	1/204	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG80CKWR	GO:0061327	1/204	anterior Malpighian tubule development	biological_process	"The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG80CKWR	GO:0007520	1/204	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG80CKWR	GO:0032314	1/204	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG80CKWR	GO:0005886	1/204	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80CKWR	GO:0000902	1/204	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG80CKWR	GO:0019897	1/204	extrinsic component of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]
EOG841SV4	GO:0006281	3/14	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG841SV4	GO:0051382	3/14	kinetochore assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]
EOG8WSZQW	GO:0004197	24/35	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8WSZQW	GO:0006915	22/35	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8WSZQW	GO:0012501	2/35	programmed cell death	biological_process	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]
EOG8WSZQW	GO:0005737	2/35	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WSZQW	GO:0046672	1/35	positive regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG8WSZQW	GO:0006508	1/35	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8WSZQW	GO:0035070	1/35	salivary gland histolysis	biological_process	"The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683]
EOG8WSZQW	GO:0045476	1/35	nurse cell apoptotic process	biological_process	"Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306]
EOG8MGVPP	GO:0005576	1/172	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8MGVPP	GO:0006355	1/172	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8MGVPP	GO:0043565	1/172	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG844P1Z	GO:0008270	2/8	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WSZQB	GO:0016021	3/137	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WSZQB	GO:0004721	2/137	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8WSZQB	GO:0000166	1/137	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8WSZQB	GO:0003676	1/137	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MGVPJ	GO:0003676	23/88	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MGVPJ	GO:0004527	20/88	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8MGVPJ	GO:0008859	1/88	exoribonuclease II activity	molecular_function	"Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684]
EOG8FXTQD	GO:0004252	6/16	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8WSZQM	GO:0016021	181/562	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WSZQM	GO:0015116	160/562	sulfate transmembrane transporter activity	molecular_function	"Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai]
EOG8WSZQM	GO:0008271	20/562	secondary active sulfate transmembrane transporter activity	molecular_function	"Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
EOG8WSZQM	GO:0055085	1/562	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8WSZQM	GO:0045434	1/562	negative regulation of female receptivity, post-mating	biological_process	"Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating." [GOC:bf, PMID:11092827]
EOG82Z762	GO:0016021	1/95	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8STVM4	GO:0004252	2/6	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG81C9BD	GO:0006596	3/8	polyamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]
EOG81C9BD	GO:0003824	3/8	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG81C9BG	GO:0046872	2/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81C9BG	GO:0003676	2/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8STVM0	GO:0016021	1/3	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8STVM3	GO:0005634	19/83	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8STVM3	GO:0022008	1/83	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8X6FP2	GO:0005615	1/111	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8X6FP2	GO:0035556	1/111	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8X6FP2	GO:0016021	1/111	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X6FP2	GO:0005875	1/111	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8X6FP2	GO:0005787	1/111	signal peptidase complex	cellular_component	"A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509]
EOG8X6FP2	GO:0008233	1/111	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8X6FP2	GO:0006465	1/111	signal peptide processing	biological_process	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]
EOG8JQ6CJ	GO:0006030	35/74	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8JQ6CJ	GO:0008061	35/74	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8JQ6CJ	GO:0005576	35/74	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG89628X	GO:0003677	2/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG89628X	GO:0000785	1/5	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG89628X	GO:0006355	1/5	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG89628X	GO:0005634	1/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8STVMQ	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X6FPH	GO:0003676	3/9	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X6FPH	GO:0008270	3/9	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X6FPH	GO:0005634	3/9	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X6FPH	GO:0046872	1/9	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG812PKZ	GO:0006979	3/8	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG812PKZ	GO:0020037	3/8	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG812PKZ	GO:0004601	3/8	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG8X6FPQ	GO:0006464	47/145	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG8X6FPQ	GO:0005524	6/145	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X6FPQ	GO:0004835	3/145	tubulin-tyrosine ligase activity	molecular_function	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]
EOG8X6FPQ	GO:0016874	3/145	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8X6FPX	GO:0003824	177/787	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8X6FPX	GO:0047077	20/787	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	molecular_function	"Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin." [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN]
EOG8X6FPX	GO:0016874	19/787	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8X6FPX	GO:0004497	7/787	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8X6FPX	GO:0008756	4/787	o-succinylbenzoate-CoA ligase activity	molecular_function	"Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate." [EC:6.2.1.26]
EOG8X6FPX	GO:0004467	2/787	long-chain fatty acid-CoA ligase activity	molecular_function	"Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.3]
EOG8X6FPX	GO:0005524	2/787	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X6FPX	GO:0006637	1/787	acyl-CoA metabolic process	biological_process	"The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732]
EOG8X6FPX	GO:0046627	1/787	negative regulation of insulin receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8X6FPX	GO:0046949	1/787	fatty-acyl-CoA biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732]
EOG8X6FPX	GO:0005777	1/787	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8X6FPX	GO:0019433	1/787	triglyceride catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732]
EOG8X6FPX	GO:0001676	1/787	long-chain fatty acid metabolic process	biological_process	"The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ajp]
EOG8X6FPX	GO:0004321	1/787	fatty-acyl-CoA synthase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86]
EOG8X6FPX	GO:0071616	1/787	acyl-CoA biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [GOC:cjk]
EOG8X6FPX	GO:0016021	1/787	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X6FPX	GO:0042626	1/787	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8X6FPX	GO:0009062	1/787	fatty acid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]
EOG8X6FPX	GO:0016887	1/787	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8X6FPX	GO:0008218	1/787	bioluminescence	biological_process	"The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732]
EOG84N15W	GO:0008236	24/112	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG84N15W	GO:0016020	24/112	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG84N15W	GO:0006508	3/112	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG84N15T	GO:0016539	5/75	intein-mediated protein splicing	biological_process	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]
EOG84N15T	GO:0017111	4/75	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG84N15T	GO:0005524	4/75	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG84N15T	GO:0005875	1/75	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8577N7	GO:0005097	13/64	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8FJBS3	GO:0003676	72/1100	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FJBS3	GO:0003964	71/1100	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8FJBS3	GO:0004523	69/1100	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8FJBS3	GO:0003723	34/1100	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8FJBS3	GO:0008270	8/1100	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FJBS3	GO:0004519	1/1100	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8FJBS3	GO:0004842	1/1100	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8FJBS8	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG808QPG	GO:0005507	2/5	copper ion binding	molecular_function	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]
EOG808QPG	GO:0016491	2/5	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8JHFZ8	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JHFZ8	GO:0005230	1/4	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG815JV0	GO:0080019	2/5	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8JHFZ3	GO:0008270	3/50	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8JHFZ3	GO:0006886	3/50	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8JHFZ3	GO:0006888	3/50	ER to Golgi vesicle-mediated transport	biological_process	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]
EOG8JHFZ3	GO:0030127	3/50	COPII vesicle coat	cellular_component	"One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]
EOG8DZ48Z	GO:0046872	103/368	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DZ48Z	GO:0003676	100/368	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DZ48Z	GO:0043565	4/368	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8DZ48Z	GO:0050774	1/368	negative regulation of dendrite morphogenesis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG8DZ48Z	GO:0048814	1/368	regulation of dendrite morphogenesis	biological_process	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG8DZ48Z	GO:0022008	1/368	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8DZ48B	GO:0022008	1/106	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8DZ48M	GO:0003676	4/11	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DZ48M	GO:0008270	2/11	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DZ48M	GO:0046872	2/11	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DZ48M	GO:0005634	2/11	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8H74T8	GO:0016740	1/3	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG84J50Q	GO:0000226	1/4	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG84J50Q	GO:0005874	1/4	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG85F06G	GO:0005634	3/6	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85F06G	GO:0003700	3/6	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG85F06G	GO:0043565	2/6	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG85F06G	GO:0000976	1/6	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG85B3VK	GO:0007050	5/43	cell cycle arrest	biological_process	"A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]
EOG82RGN7	GO:0003676	1/31	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82RGN7	GO:0046872	1/31	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82RGN8	GO:0005506	11/48	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG82RGN8	GO:0020037	11/48	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG82RGN8	GO:0016705	11/48	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG82RGN8	GO:0004497	10/48	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8Z0DNX	GO:0007275	2/27	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8Z0DNX	GO:0016021	2/27	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z0DNX	GO:0007154	2/27	cell communication	biological_process	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]
EOG82RGNK	GO:0006355	5/212	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82RGNK	GO:0006200	3/212	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG82RGNK	GO:0007018	3/212	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG82RGNK	GO:0042623	3/212	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG82RGNK	GO:0030286	2/212	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG82RGNK	GO:0005875	2/212	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG82RGNK	GO:0007605	1/212	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG82RGNJ	GO:0003779	1/62	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG82RGNJ	GO:0031463	1/62	Cul3-RING ubiquitin ligase complex	cellular_component	"A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063]
EOG82RGNJ	GO:0046529	1/62	imaginal disc fusion, thorax closure	biological_process	"The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm]
EOG87WR59	GO:0008270	1/3	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87WR59	GO:0005634	1/3	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82RGNQ	GO:0004096	47/133	catalase activity	molecular_function	"Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6]
EOG82RGNQ	GO:0020037	47/133	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG82RGNQ	GO:0046872	40/133	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82RGNQ	GO:0006979	26/133	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG82RGNQ	GO:0042744	21/133	hydrogen peroxide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]
EOG82RGNQ	GO:0007568	1/133	aging	biological_process	"A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death (GO:0016265) and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators]
EOG82RGNQ	GO:0042542	1/133	response to hydrogen peroxide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]
EOG82RGNQ	GO:0016209	1/133	antioxidant activity	molecular_function	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
EOG82RGNQ	GO:0005777	1/133	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG82RGNQ	GO:0035206	1/133	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG82RGNQ	GO:0008340	1/133	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG82RGNW	GO:0016811	1/110	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]
EOG8Z0DNK	GO:0007067	1/65	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8Z0DNK	GO:0007279	1/65	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8Z0DNK	GO:0016319	1/65	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8Z0DNK	GO:0005634	1/65	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PVRCV	GO:0004871	24/95	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8PVRCV	GO:0005634	23/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PVRCV	GO:0003677	22/95	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8PVRCV	GO:0006351	22/95	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8PVRCV	GO:0006355	16/95	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8PVRCV	GO:0005737	7/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8PVRCV	GO:0003700	6/95	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8PVRCV	GO:0005667	6/95	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8PVRCV	GO:0048477	1/95	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8PVRCV	GO:0051726	1/95	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8PVRCV	GO:0010508	1/95	positive regulation of autophagy	biological_process	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8PVRCV	GO:0032869	1/95	cellular response to insulin stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]
EOG8PVRCV	GO:0071456	1/95	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG8PVRCV	GO:0030308	1/95	negative regulation of cell growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8PVRCV	GO:0030334	1/95	regulation of cell migration	biological_process	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]
EOG8PVRCV	GO:0003989	1/95	acetyl-CoA carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2]
EOG8PVRCV	GO:0006974	1/95	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8PVRCV	GO:0060438	1/95	trachea development	biological_process	"The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG8PVRCV	GO:0045944	1/95	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8PVRCQ	GO:0007165	5/92	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8PVRCQ	GO:0004497	4/92	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8PVRCQ	GO:0005506	1/92	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8PVRCQ	GO:0020037	1/92	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8PVRCQ	GO:0016705	1/92	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8N5ZC3	GO:0003677	54/254	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8N5ZC3	GO:0046872	35/254	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8N5ZC3	GO:0003676	10/254	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8N5ZC3	GO:0005634	4/254	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8N5ZC3	GO:0005515	3/254	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8N5ZC3	GO:0005700	2/254	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8N5ZC3	GO:0003700	2/254	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8N5ZC3	GO:0007455	2/254	eye-antennal disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8N5ZC3	GO:0006351	2/254	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8N5ZC3	GO:0003680	2/254	AT DNA binding	molecular_function	"Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, PMID:2670564]
EOG8N5ZC3	GO:0006355	2/254	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8N5ZC3	GO:0007478	2/254	leg disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
EOG8N5ZC3	GO:0045944	1/254	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8N5ZC3	GO:0043388	1/254	positive regulation of DNA binding	biological_process	"Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
EOG8N5ZC3	GO:0030707	1/254	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8N5ZC3	GO:0007476	1/254	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8N5ZC3	GO:0001964	1/254	startle response	biological_process	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
EOG8N5ZC3	GO:0048071	1/254	sex-specific pigmentation	biological_process	"Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jid]
EOG8N5ZC3	GO:0042682	1/254	regulation of compound eye cone cell fate specification	biological_process	"Any process that mediates the specification of a cell into a compound eye cone cell." [GOC:mtg_sensu]
EOG8N5ZC3	GO:0007422	1/254	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8N5ZC3	GO:0061040	1/254	female gonad morphogenesis	biological_process	"The process in which a female gonad is generated and organized." [GOC:BHF, GOC:dph]
EOG8N5ZC3	GO:0042675	1/254	compound eye cone cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu]
EOG8N5ZC3	GO:0008270	1/254	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8N5ZC3	GO:0060446	1/254	branching involved in open tracheal system development	biological_process	"The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph]
EOG8N5ZC3	GO:0046660	1/254	female sex differentiation	biological_process	"The establishment of the sex of a female organism by physical differentiation." [GOC:bf]
EOG8N5ZC3	GO:0002121	1/254	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8N5ZC3	GO:0031987	1/254	locomotion involved in locomotory behavior	biological_process	"Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
EOG8N5ZC3	GO:0048854	1/254	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG8N5ZC3	GO:0000978	1/254	RNA polymerase II core promoter proximal region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II." [GOC:txnOH]
EOG8N5ZC3	GO:0001709	1/254	cell fate determination	biological_process	"A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
EOG8N5ZC3	GO:0003682	1/254	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8N5ZC3	GO:0000122	1/254	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8N5ZC3	GO:0017053	1/254	transcriptional repressor complex	cellular_component	"A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah]
EOG8N5ZC3	GO:0048092	1/254	negative regulation of male pigmentation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid]
EOG8N5ZC3	GO:0048070	1/254	regulation of developmental pigmentation	biological_process	"Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
EOG8N5ZC3	GO:0031208	1/254	POZ domain binding	molecular_function	"Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847]
EOG8N5ZC3	GO:0035147	1/254	branch fusion, open tracheal system	biological_process	"Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584]
EOG8N5ZC3	GO:0046843	1/254	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8N5ZC3	GO:0001078	1/254	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
EOG8N5ZC3	GO:0008360	1/254	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8N5ZC3	GO:0035001	1/254	dorsal trunk growth, open tracheal system	biological_process	"Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system." [GOC:mtg_sensu, ISBN:0879694238]
EOG8N5ZC3	GO:0007548	1/254	sex differentiation	biological_process	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]
EOG8N5ZC3	GO:0016476	1/254	regulation of embryonic cell shape	biological_process	"Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb]
EOG8N5ZC3	GO:0007298	1/254	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8N5ZC3	GO:0048750	1/254	compound eye corneal lens morphogenesis	biological_process	"The process in which the anatomical structures of the compound eye corneal lens are generated and organized." [GOC:jid]
EOG8N5ZC3	GO:0045467	1/254	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8N5ZC3	GO:0048666	1/254	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8N5ZC3	GO:0048053	1/254	R1/R6 development	biological_process	"The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid]
EOG8N5ZC3	GO:0040003	1/254	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8N5ZC3	GO:0042803	1/254	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8N5ZC3	GO:0048086	1/254	negative regulation of developmental pigmentation	biological_process	"Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
EOG8N5ZC3	GO:0000980	1/254	RNA polymerase II distal enhancer sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH]
EOG8N5ZC3	GO:0007426	1/254	tracheal outgrowth, open tracheal system	biological_process	"The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8N5ZC3	GO:0048813	1/254	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8N5ZC3	GO:0045892	1/254	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8N5ZC3	GO:0035151	1/254	regulation of tube size, open tracheal system	biological_process	"Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]
EOG8K6JMG	GO:0005549	2/6	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8ZGRV3	GO:0006950	1/5	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG815JVS	GO:0000166	57/140	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG815JVS	GO:0003676	54/140	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG815JVS	GO:0030529	6/140	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG815JVS	GO:0019013	4/140	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG815JVS	GO:0003729	3/140	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG815JVS	GO:0005703	2/140	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG815JVS	GO:0000381	2/140	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG815JVS	GO:0043565	2/140	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG815JVS	GO:0005634	2/140	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG815JVS	GO:0045727	1/140	positive regulation of translation	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb]
EOG815JVS	GO:0035062	1/140	omega speckle	cellular_component	"A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439]
EOG815JVS	GO:0007286	1/140	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG815JVS	GO:0033119	1/140	negative regulation of RNA splicing	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing." [GOC:mah]
EOG815JVS	GO:0009408	1/140	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG815JVS	GO:0022008	1/140	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG815JVS	GO:0007275	1/140	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG815JVS	GO:0008585	1/140	female gonad development	biological_process	"The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb]
EOG815JVS	GO:0005737	1/140	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG815JVS	GO:0048477	1/140	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG815JVS	GO:0000785	1/140	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG815JVS	GO:0005654	1/140	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG815JVS	GO:0048027	1/140	mRNA 5'-UTR binding	molecular_function	"Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule." [GOC:jid]
EOG815JVS	GO:0007067	1/140	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG815JVS	GO:0036099	1/140	female germ-line stem cell population maintenance	biological_process	"The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart]
EOG815JVS	GO:0042594	1/140	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8H74TK	GO:0005576	1/3	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8H74TK	GO:0006629	1/3	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8H74TK	GO:0003824	1/3	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8H74TQ	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZPH8F	GO:0005089	23/128	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8ZPH8F	GO:0035556	2/128	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8ZPH8F	GO:0004833	1/128	tryptophan 2,3-dioxygenase activity	molecular_function	"Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11]
EOG8ZPH8F	GO:0020037	1/128	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8ZPH8F	GO:0019441	1/128	tryptophan catabolic process to kynurenine	biological_process	"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]
EOG8ZPH8G	GO:0006066	2/5	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG8ZPH8G	GO:0008812	2/5	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG8ZPH8G	GO:0050660	2/5	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8ZPH8N	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZPH8N	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8F7R1H	GO:0005525	2/20	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8F7R1H	GO:0004871	2/20	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8F7R1H	GO:0003924	2/20	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8F7R1H	GO:0007186	2/20	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8ZPH8Q	GO:0008306	1/99	associative learning	biological_process	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
EOG8ZPH8Q	GO:0048172	1/99	regulation of short-term neuronal synaptic plasticity	biological_process	"A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290]
EOG8ZPH8Q	GO:0045202	1/99	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8ZPH8Q	GO:0007268	1/99	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8BCH22	GO:0016758	383/1077	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8BCH22	GO:0030259	14/1077	lipid glycosylation	biological_process	"Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah]
EOG8BCH22	GO:0015020	13/1077	glucuronosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17]
EOG8BCH22	GO:0030246	12/1077	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8BCH22	GO:0016999	11/1077	antibiotic metabolic process	biological_process	"The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2]
EOG8BCH22	GO:0016740	3/1077	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8BCH22	GO:0004181	1/1077	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG8BCH22	GO:0008168	1/1077	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8BCH22	GO:0003851	1/1077	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45]
EOG8BCH22	GO:0008270	1/1077	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BCH22	GO:0003676	1/1077	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BCH22	GO:0002121	1/1077	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG88D389	GO:0007165	19/141	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG88D389	GO:0007432	1/141	salivary gland boundary specification	biological_process	"Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957]
EOG88D389	GO:0008347	1/141	glial cell migration	biological_process	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
EOG88D389	GO:0050919	1/141	negative chemotaxis	biological_process	"The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete]
EOG88D389	GO:0008045	1/141	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG88D389	GO:0007411	1/141	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG88D389	GO:0005515	1/141	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG88D389	GO:0005043	1/141	netrin receptor activity involved in chemorepulsion	molecular_function	"Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin." [GOC:dph, GOC:signaling]
EOG88D389	GO:0016021	1/141	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88SK8R	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG88SK8R	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SFCN9	GO:0005576	2/5	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8SFCN9	GO:0006629	2/5	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8SFCN9	GO:0003824	1/5	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8SFCN9	GO:0016787	1/5	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8V19DN	GO:0035195	1/101	gene silencing by miRNA	biological_process	"Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortgening and subsequent degredation of the mRNA." [PMID:14744438, PMID:15066275, PMID:15066283, PMID:23209154]
EOG8V19DN	GO:0033962	1/101	cytoplasmic mRNA processing body assembly	biological_process	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074]
EOG8V19DN	GO:0050832	1/101	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8V19DN	GO:0000932	1/101	cytoplasmic mRNA processing body	cellular_component	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603]
EOG8V19DN	GO:0045451	1/101	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8V19DN	GO:0006402	1/101	mRNA catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]
EOG8V19DN	GO:0005515	1/101	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG89S8N1	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89S8N1	GO:0022891	2/5	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8ZKN4W	GO:0005615	1/6	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG88SK80	GO:0016021	29/89	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88SK80	GO:0006810	29/89	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG88D38T	GO:0006066	3/6	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG88D38T	GO:0008812	3/6	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG88D38T	GO:0050660	3/6	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG88D38W	GO:0016788	294/950	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG88D38W	GO:0016042	262/950	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG88D38W	GO:0006629	148/950	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG88D38W	GO:0004806	8/950	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG88D38W	GO:0005615	5/950	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG88D38W	GO:0032504	5/950	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG88D38W	GO:0016298	4/950	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG88D38W	GO:0030246	1/950	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG88D38W	GO:0016787	1/950	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG88D38W	GO:0003676	1/950	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88D38W	GO:0007586	1/950	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG88D38W	GO:0042632	1/950	cholesterol homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]
EOG88D38W	GO:0006886	1/950	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG88D38W	GO:0048812	1/950	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG88D38W	GO:0016192	1/950	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG88D38W	GO:0005576	1/950	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG88D38W	GO:0030132	1/950	clathrin coat of coated pit	cellular_component	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]
EOG88D38W	GO:0030130	1/950	clathrin coat of trans-Golgi network vesicle	cellular_component	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]
EOG88D38W	GO:0005198	1/950	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG88D38W	GO:0031410	1/950	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG88D38W	GO:0070328	1/950	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG88D38W	GO:0004771	1/950	sterol esterase activity	molecular_function	"Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13]
EOG8SFCNC	GO:0007165	1/4	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG89S8NG	GO:0006629	2/6	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG89S8NG	GO:0005576	2/6	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG89S8NG	GO:0016787	2/6	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8F7R11	GO:0016021	3/229	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F7R11	GO:0006909	3/229	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8F7R11	GO:0042742	2/229	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8F7R11	GO:0005886	1/229	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8F7R11	GO:0006910	1/229	phagocytosis, recognition	biological_process	"The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149]
EOG8F7R11	GO:0046331	1/229	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8F7R11	GO:0009986	1/229	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8F7R11	GO:0005615	1/229	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8F7R11	GO:0006898	1/229	receptor-mediated endocytosis	biological_process	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
EOG8F7R11	GO:0005044	1/229	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8F7R11	GO:0008233	1/229	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8F7R11	GO:0042834	1/229	peptidoglycan binding	molecular_function	"Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226]
EOG8F7R12	GO:0004970	18/72	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8F7R12	GO:0016020	18/72	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8F7R12	GO:0005234	18/72	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8F7R12	GO:0005634	1/72	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8F7R12	GO:0008270	1/72	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZPH82	GO:0055037	1/113	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG8ZPH82	GO:0032483	1/113	regulation of Rab protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]
EOG8ZPH82	GO:0045175	1/113	basal protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf]
EOG8ZPH82	GO:0005516	1/113	calmodulin binding	molecular_function	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
EOG8ZPH82	GO:0031410	1/113	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG8ZPH82	GO:0042998	1/113	positive regulation of Golgi to plasma membrane protein transport	biological_process	"Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
EOG8ZPH82	GO:0017112	1/113	Rab guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8ZPH82	GO:0070831	1/113	basement membrane assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue." [GOC:mah]
EOG8ZPH82	GO:0008105	1/113	asymmetric protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma]
EOG8ZPH82	GO:0050829	1/113	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8ZPH82	GO:0005938	1/113	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8ZPH82	GO:0045089	1/113	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8ZPH82	GO:0017137	1/113	Rab GTPase binding	molecular_function	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG8ZPH82	GO:0032313	1/113	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8BCH2W	GO:0003676	1/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BCH2W	GO:0046872	1/7	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8W9MJT	GO:0008299	27/163	isoprenoid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
EOG8W9MJT	GO:0016740	24/163	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8W9MJT	GO:0004161	3/163	dimethylallyltranstransferase activity	molecular_function	"Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate." [EC:2.5.1.1]
EOG8W9MJT	GO:0008354	1/163	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8W9MJT	GO:0035220	1/163	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8W9MJT	GO:0004337	1/163	geranyltranstransferase activity	molecular_function	"Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate." [EC:2.5.1.10, RHEA:19364]
EOG8D81N7	GO:0005215	4/22	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8D81N7	GO:0005622	4/22	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG873S5R	GO:0016021	3/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG825885	GO:0005634	1/317	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG825885	GO:0005576	1/317	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG825885	GO:0003743	1/317	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG825885	GO:0050830	1/317	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG825885	GO:0032504	1/317	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG825885	GO:0002759	1/317	regulation of antimicrobial humoral response	biological_process	"Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]
EOG825885	GO:0050829	1/317	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG825885	GO:0005615	1/317	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8V45PW	GO:0003676	6/27	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V45PW	GO:0005634	5/27	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8V45PW	GO:0008270	5/27	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V45PW	GO:0046872	2/27	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG88WFFS	GO:0003735	1/49	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG88WFFS	GO:0015934	1/49	large ribosomal subunit	cellular_component	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]
EOG88WFFS	GO:0035091	1/49	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG88WFFS	GO:0006412	1/49	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8W9MJC	GO:0016787	3/25	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8W9MJC	GO:0003676	3/25	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W9MJC	GO:0046872	3/25	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8V45PJ	GO:0008138	26/94	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG8V45PJ	GO:0004725	24/94	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8V45PJ	GO:0006470	2/94	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8V45PJ	GO:0046872	2/94	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8V45PJ	GO:0043508	1/94	negative regulation of JUN kinase activity	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity." [GOC:jl]
EOG8V45PJ	GO:0016791	1/94	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG8V45PJ	GO:0005634	1/94	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8V45PC	GO:0008643	2/5	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8V45PC	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V45PC	GO:0022891	2/5	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8V45PC	GO:0032440	1/5	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG873S5C	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG873S5C	GO:0045211	1/5	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG873S5C	GO:0005234	1/5	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG873S5C	GO:0004970	1/5	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG873S5C	GO:0005215	1/5	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG873S5C	GO:0030054	1/5	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG873S5G	GO:0008270	21/89	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG873S5G	GO:0007165	20/89	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG873S5G	GO:0040014	1/89	regulation of multicellular organism growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG873S5G	GO:0005515	1/89	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG873S5G	GO:0009968	1/89	negative regulation of signal transduction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]
EOG873S5G	GO:0010332	1/89	response to gamma radiation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators, Wikipedia:Gamma_ray]
EOG8PP0X0	GO:0005813	1/81	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8PP0X0	GO:0007338	1/81	single fertilization	biological_process	"The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu]
EOG8PP0X0	GO:0007288	1/81	sperm axoneme assembly	biological_process	"The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, ISBN:0198547684]
EOG8PP0X0	GO:0007099	1/81	centriole replication	biological_process	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194]
EOG8PP0X0	GO:0007098	1/81	centrosome cycle	biological_process	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]
EOG8PP0X0	GO:0035058	1/81	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG8PP0X0	GO:0051297	1/81	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8PP0X0	GO:0008356	1/81	asymmetric cell division	biological_process	"The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
EOG8PP0X0	GO:0005814	1/81	centriole	cellular_component	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
EOG8PP0X0	GO:0000242	1/81	pericentriolar material	cellular_component	"A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]
EOG8PP0X0	GO:0036064	1/81	ciliary basal body	cellular_component	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]
EOG8Q5C57	GO:0007155	30/134	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8Q5C57	GO:0031012	30/134	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8Q5C57	GO:0005198	30/134	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8Q5C57	GO:0005581	24/134	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8Q5C57	GO:0008045	1/134	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8Q5C57	GO:0030246	1/134	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8Q5C57	GO:2001046	1/134	positive regulation of integrin-mediated signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol]
EOG8Q5C57	GO:0071711	1/134	basement membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah]
EOG8Q5C57	GO:0014732	1/134	skeletal muscle atrophy	biological_process	"A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle]
EOG8Q5C57	GO:0007005	1/134	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8Q5C57	GO:0014899	1/134	cardiac muscle atrophy	biological_process	"A process, occurring in the heart, in which a decrease in cell mass and then in heart size occurs due to shrinking of the individual cells. The shrinkage is caused by protein degradation." [GOC:mtg_muscle]
EOG8M67ZB	GO:0030414	21/115	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8M67ZB	GO:0005576	21/115	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8M67ZB	GO:0016787	2/115	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8M67ZB	GO:0016020	1/115	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8M67ZB	GO:0004930	1/115	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8Q5C53	GO:0016491	1/3	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG81G5K7	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG81G5K7	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81G5K4	GO:0003700	50/159	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG81G5K4	GO:0005634	43/159	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81G5K4	GO:0043565	31/159	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG81G5K4	GO:0000976	19/159	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG81G5K4	GO:0007275	2/159	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG81G5K4	GO:0007480	1/159	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG81G5K4	GO:0021782	1/159	glial cell development	biological_process	"The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG81G5K4	GO:0048800	1/159	antennal morphogenesis	biological_process	"The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid]
EOG81G5K4	GO:0045944	1/159	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG81G5K4	GO:0035015	1/159	elongation of arista core	biological_process	"The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081]
EOG81G5K4	GO:0005737	1/159	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG81G5K4	GO:0045747	1/159	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG81G5K4	GO:0035218	1/159	leg disc development	biological_process	"Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
EOG81G5K4	GO:0000977	1/159	RNA polymerase II regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
EOG81G5K4	GO:0007399	1/159	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG81G5K4	GO:0007422	1/159	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG81G5K4	GO:0010628	1/159	positive regulation of gene expression	biological_process	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG81G5K4	GO:0022416	1/159	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG81G5K4	GO:0045892	1/159	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG81G5K4	GO:0005515	1/159	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG81G5K4	GO:0043234	1/159	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG81G5K4	GO:0010001	1/159	glial cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]
EOG81G5K4	GO:0001077	1/159	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG8JWXTV	GO:0004930	6/22	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8JWXTV	GO:0005886	5/22	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8JWXTV	GO:0016021	5/22	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JWXTV	GO:0016020	1/22	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8JWXTS	GO:0016020	4/111	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8JWXTS	GO:0042250	1/111	maintenance of polarity of embryonic epithelium	biological_process	"The maintenance of an established polarized embryonic epithelial sheet." [GOC:jl]
EOG8JWXTS	GO:0007431	1/111	salivary gland development	biological_process	"The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044]
EOG8JWXTS	GO:0007443	1/111	Malpighian tubule morphogenesis	biological_process	"The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089]
EOG8JWXTS	GO:0007440	1/111	foregut morphogenesis	biological_process	"The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid]
EOG8JWXTS	GO:0002009	1/111	morphogenesis of an epithelium	biological_process	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
EOG8JWXTS	GO:0008258	1/111	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8JWXTS	GO:0007391	1/111	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8JWXTS	GO:0007510	1/111	cardioblast cell fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG8JWXTS	GO:0007435	1/111	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8M67ZS	GO:0006629	3/11	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8PP0XV	GO:0005524	21/86	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8PP0XV	GO:0004674	20/86	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8PP0XV	GO:0004672	1/86	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8PP0XV	GO:0004709	1/86	MAP kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
EOG8PP0XV	GO:0006468	1/86	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8PP0XV	GO:0032008	1/86	positive regulation of TOR signaling	biological_process	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8R269T	GO:0004930	2/5	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8R269T	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80KBCS	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80KBCS	GO:0003677	2/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80KBCS	GO:0006355	2/5	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG81G5KV	GO:0003824	1/4	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG81G5KV	GO:0005576	1/4	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG81G5KV	GO:0006629	1/4	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8BP3ST	GO:0006535	2/10	cysteine biosynthetic process from serine	biological_process	"The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators]
EOG8JWXT7	GO:0007519	1/166	skeletal muscle tissue development	biological_process	"The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
EOG8JWXT7	GO:0008307	1/166	structural constituent of muscle	molecular_function	"The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah]
EOG8JWXT7	GO:0016203	1/166	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8JWXT7	GO:0000794	1/166	condensed nuclear chromosome	cellular_component	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh]
EOG8JWXT7	GO:0007062	1/166	sister chromatid cohesion	biological_process	"The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other." [GOC:jh, GOC:mah, ISBN:0815316194]
EOG8JWXT7	GO:0035206	1/166	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8JWXT7	GO:0007522	1/166	visceral muscle development	biological_process	"The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators]
EOG8JWXT7	GO:0007525	1/166	somatic muscle development	biological_process	"The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
EOG8JWXT7	GO:0030018	1/166	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8JWXT7	GO:0003779	1/166	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8JWXT7	GO:0007076	1/166	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8JWXT7	GO:0040011	1/166	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG8JWXT7	GO:0007517	1/166	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8JWXT7	GO:0007520	1/166	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG8JWXT7	GO:0030017	1/166	sarcomere	cellular_component	"The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]
EOG8JWXT7	GO:0045214	1/166	sarcomere organization	biological_process	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
EOG8JWXT7	GO:0007498	1/166	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8JWXT7	GO:0005875	1/166	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8JWXT7	GO:0016301	1/166	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8R52H1	GO:0005524	5/39	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8R52H1	GO:0003777	5/39	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8R52H1	GO:0005871	5/39	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8R52H1	GO:0007018	5/39	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8R52H1	GO:0005874	4/39	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8R52H0	GO:0006096	32/120	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8R52H0	GO:0004634	32/120	phosphopyruvate hydratase activity	molecular_function	"Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732]
EOG8R52H0	GO:0000015	32/120	phosphopyruvate hydratase complex	cellular_component	"A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732]
EOG8R52H0	GO:0000287	32/120	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8R52H0	GO:0005811	1/120	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8D81NQ	GO:0048190	1/53	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8V45P1	GO:0004674	2/5	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8V45P1	GO:0005524	2/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X6FPK	GO:0005524	38/127	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X6FPK	GO:0004674	37/127	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8X6FPK	GO:0050321	3/127	tau-protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]
EOG8X6FPK	GO:0004672	2/127	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8X6FPK	GO:0006468	2/127	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8X6FPK	GO:0030054	1/127	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8X6FPK	GO:0016301	1/127	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8X6FPK	GO:0005634	1/127	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X6FPK	GO:0045879	1/127	negative regulation of smoothened signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG8X6FPK	GO:0072347	1/127	response to anesthetic	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart]
EOG8X6FPK	GO:0045475	1/127	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8X6FPK	GO:0032436	1/127	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	biological_process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]
EOG8X6FPK	GO:0016055	1/127	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG8X6FPK	GO:0008355	1/127	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8X6FPK	GO:0048477	1/127	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8X6FPK	GO:0030178	1/127	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8X6FPK	GO:0045169	1/127	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG8X6FPK	GO:0035293	1/127	chitin-based larval cuticle pattern formation	biological_process	"The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8X6FPK	GO:0045610	1/127	regulation of hemocyte differentiation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG8X6FPK	GO:0005813	1/127	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8X6FPK	GO:0031594	1/127	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8X6FPK	GO:0090163	1/127	establishment of epithelial cell planar polarity	biological_process	"The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8X6FPK	GO:0007219	1/127	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8X6FPK	GO:0072686	1/127	mitotic spindle	cellular_component	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
EOG8X6FPK	GO:0005737	1/127	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8X6FPK	GO:0045886	1/127	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8X6FPK	GO:0007623	1/127	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG8X6FPK	GO:0007367	1/127	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG8X6FPK	GO:0008407	1/127	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG8X6FPK	GO:0042306	1/127	regulation of protein import into nucleus	biological_process	"Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl]
EOG8X6FPK	GO:0005515	1/127	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8X6FPK	GO:0046959	1/127	habituation	biological_process	"A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089]
EOG8X6FPK	GO:0009649	1/127	entrainment of circadian clock	biological_process	"The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid]
EOG8X6FPK	GO:0005938	1/127	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8X6FPK	GO:0030162	1/127	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8X6FPK	GO:0043508	1/127	negative regulation of JUN kinase activity	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity." [GOC:jl]
EOG8X6FPK	GO:0035309	1/127	wing and notum subfield formation	biological_process	"The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999]
EOG8X6FPK	GO:0030424	1/127	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8X6FPK	GO:0007622	1/127	rhythmic behavior	biological_process	"The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr]
EOG8X6FPK	GO:0005654	1/127	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG8X6FPK	GO:0045732	1/127	positive regulation of protein catabolic process	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]
EOG8X6FPK	GO:0007143	1/127	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8X6FPK	GO:0042752	1/127	regulation of circadian rhythm	biological_process	"Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]
EOG8X6FPK	GO:0051124	1/127	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8X6FPK	GO:0030589	1/127	pseudocleavage involved in syncytial blastoderm formation	biological_process	"Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8X6FPK	GO:0003382	1/127	epithelial cell morphogenesis	biological_process	"The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8X6FPK	GO:0045842	1/127	positive regulation of mitotic metaphase/anaphase transition	biological_process	"Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
EOG8X6FPK	GO:0007423	1/127	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8X6FPK	GO:0035324	1/127	female germline ring canal	cellular_component	"An intercellular bridge that connects the germline cells of a female cyst." [PMID:9635420]
EOG8X6FPK	GO:0070507	1/127	regulation of microtubule cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8X6FPK	GO:0048232	1/127	male gamete generation	biological_process	"Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." [GOC:dph, GOC:jid]
EOG8X6FPK	GO:0007507	1/127	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8X6FPK	GO:0035019	1/127	somatic stem cell population maintenance	biological_process	"Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089]
EOG8X6FPK	GO:0030707	1/127	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8X6FPK	GO:0070884	1/127	regulation of calcineurin-NFAT signaling cascade	biological_process	"Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:ai]
EOG8X6FPK	GO:0007051	1/127	spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:mah]
EOG8D81NB	GO:0003677	4/41	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8D81NB	GO:0003676	1/41	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NS5R7	GO:0007018	11/52	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8NS5R7	GO:0003777	11/52	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8NS5R7	GO:0030286	8/52	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8NS5R7	GO:0005524	5/52	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8NS5R7	GO:0016887	3/52	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8NS5R7	GO:0008270	1/52	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NS5R7	GO:0000166	1/52	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8NS5R7	GO:0042623	1/52	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8NS5R7	GO:0006200	1/52	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8NS5R7	GO:0004842	1/52	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG86Q97P	GO:0016021	129/334	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86Q97P	GO:0004672	1/334	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG86Q97P	GO:0005524	1/334	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG86Q97P	GO:0045169	1/334	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG8NZX77	GO:0015074	206/1674	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8NZX77	GO:0003964	173/1674	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8NZX77	GO:0003723	170/1674	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8NZX77	GO:0003676	151/1674	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NZX77	GO:0008270	67/1674	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NZX77	GO:0004190	64/1674	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8NZX77	GO:0004523	2/1674	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8NZX77	GO:0003677	2/1674	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NZX77	GO:0003899	1/1674	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8NZX77	GO:0043565	1/1674	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NZX77	GO:0005634	1/1674	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NZX77	GO:0003700	1/1674	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NZX77	GO:0004519	1/1674	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8NZX77	GO:0046872	1/1674	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NZX77	GO:0019048	1/1674	modulation by virus of host morphology or physiology	biological_process	"The process in which a virus effects a change in the structure or processes of its host organism." [GOC:bf, GOC:jl, ISBN:0781718325, UniProtKB-KW:KW-0945]
EOG8NZX77	GO:0019031	1/1674	viral envelope	cellular_component	"The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope]
EOG8NZX77	GO:0006351	1/1674	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8NZX77	GO:0008233	1/1674	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8NS5R9	GO:0016021	33/146	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NS5R9	GO:0046872	33/146	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NS5R9	GO:0005524	31/146	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8NS5R9	GO:0019829	30/146	cation-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]
EOG8NS5R9	GO:0005388	2/146	calcium-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8]
EOG8NS5R9	GO:0000166	2/146	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8NS5R9	GO:0016887	1/146	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8NS5R9	GO:0006812	1/146	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8NS5R9	GO:0004721	1/146	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8SXQT6	GO:0004181	1/5	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG8SXQT6	GO:0008270	1/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87SVVK	GO:0003677	2/4	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DV834	GO:0000276	38/108	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	cellular_component	"All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056]
EOG8DV834	GO:0015986	38/108	ATP synthesis coupled proton transport	biological_process	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]
EOG8DV834	GO:0015078	37/108	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG8DV834	GO:0016787	2/108	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8DV834	GO:0005811	1/108	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8DV834	GO:0005739	1/108	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8DV834	GO:0005875	1/108	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8DV834	GO:0008553	1/108	hydrogen-exporting ATPase activity, phosphorylative mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle." [EC:3.6.3.6]
EOG818F2D	GO:0016021	43/132	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG818F2D	GO:0044070	1/132	regulation of anion transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
EOG818F2D	GO:0005247	1/132	voltage-gated chloride channel activity	molecular_function	"Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG818F2D	GO:0050829	1/132	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG818F2D	GO:0005229	1/132	intracellular calcium activated chloride channel activity	molecular_function	"Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport]
EOG818F2D	GO:0006821	1/132	chloride transport	biological_process	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG818F2D	GO:1902476	1/132	chloride transmembrane transport	biological_process	"The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw]
EOG8XSP4F	GO:0005975	92/241	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8XSP4F	GO:0043169	75/241	cation binding	molecular_function	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]
EOG8XSP4F	GO:0016798	56/241	hydrolase activity, acting on glycosyl bonds	molecular_function	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]
EOG8XSP4F	GO:0003824	19/241	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8XSP4F	GO:0004556	17/241	alpha-amylase activity	molecular_function	"Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units." [EC:3.2.1.1]
EOG8XSP4F	GO:0046872	14/241	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XSP4F	GO:0005576	10/241	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8XSP4F	GO:0005509	2/241	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8XSP4F	GO:0030170	1/241	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8XSP4F	GO:0016740	1/241	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8XSP4F	GO:0009058	1/241	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG818F24	GO:0005525	26/123	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG818F24	GO:0007264	26/123	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG818F24	GO:0005524	26/123	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG818F24	GO:0005622	25/123	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG818F24	GO:0004674	24/123	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG818F24	GO:0004672	3/123	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG818F24	GO:0050808	1/123	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG818F24	GO:0032418	1/123	lysosome localization	biological_process	"Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]
EOG818F24	GO:1900242	1/123	regulation of synaptic vesicle endocytosis	biological_process	"Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie]
EOG818F24	GO:0018105	1/123	peptidyl-serine phosphorylation	biological_process	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]
EOG818F24	GO:0005737	1/123	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG818F24	GO:0090128	1/123	regulation of synapse maturation	biological_process	"Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG818F24	GO:0070507	1/123	regulation of microtubule cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG818F24	GO:2000331	1/123	regulation of terminal button organization	biological_process	"Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah]
EOG818F24	GO:0017137	1/123	Rab GTPase binding	molecular_function	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG818F24	GO:0016301	1/123	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG818F24	GO:0005515	1/123	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG818F24	GO:0031902	1/123	late endosome membrane	cellular_component	"The lipid bilayer surrounding a late endosome." [GOC:pz]
EOG818F24	GO:0005765	1/123	lysosomal membrane	cellular_component	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]
EOG818F24	GO:0007528	1/123	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG818F24	GO:0048312	1/123	intracellular distribution of mitochondria	biological_process	"Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid]
EOG818F24	GO:0031594	1/123	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8XSP4C	GO:0004571	37/107	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113]
EOG8XSP4C	GO:0005509	37/107	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8XSP4C	GO:0016020	36/107	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XSP4C	GO:0000139	1/107	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8XSP4C	GO:0006486	1/107	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8XSP4C	GO:0035010	1/107	encapsulation of foreign target	biological_process	"Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920]
EOG8XSP4C	GO:0008340	1/107	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8XSP4C	GO:0072347	1/107	response to anesthetic	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart]
EOG8XSP4C	GO:0016021	1/107	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XSP4N	GO:0020037	39/685	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8XSP4N	GO:0006629	26/685	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8XSP4N	GO:0046872	15/685	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XSP4N	GO:0005576	13/685	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8XSP4N	GO:0016717	12/685	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]
EOG8XSP4N	GO:0005506	12/685	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8XSP4N	GO:0006633	12/685	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8XSP4N	GO:0042438	9/685	melanin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [CHEBI:25179, GOC:curators]
EOG8XSP4N	GO:0016853	9/685	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8XSP4N	GO:0048067	9/685	cuticle pigmentation	biological_process	"Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
EOG8XSP4N	GO:0007275	3/685	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8XSP4N	GO:0016021	2/685	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XSP4N	GO:0004965	1/685	G-protein coupled GABA receptor activity	molecular_function	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor]
EOG8XSP4N	GO:0004930	1/685	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8XSP4N	GO:0048082	1/685	regulation of adult chitin-containing cuticle pigmentation	biological_process	"Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
EOG8XSP4N	GO:0005739	1/685	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8XSP4N	GO:0006583	1/685	melanin biosynthetic process from tyrosine	biological_process	"The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators]
EOG8XSP4N	GO:0007602	1/685	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG8XSP4N	GO:0007601	1/685	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8XSP4N	GO:0005737	1/685	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XSP4N	GO:0018298	1/685	protein-chromophore linkage	biological_process	"The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma]
EOG8XSP4N	GO:0005811	1/685	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8XSP4N	GO:0046331	1/685	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8XSP4N	GO:0009881	1/685	photoreceptor activity	molecular_function	"The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators]
EOG8XSP4N	GO:0060179	1/685	male mating behavior	biological_process	"The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb]
EOG8XSP4N	GO:0048066	1/685	developmental pigmentation	biological_process	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
EOG8XSP4N	GO:0048065	1/685	male courtship behavior, veined wing extension	biological_process	"The process during courtship where the male insect extends his wings. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
EOG8XSP4N	GO:0070451	1/685	cell hair	cellular_component	"A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located." [PMID:11526084]
EOG8XSP4M	GO:0046872	2/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XSP4M	GO:0003676	1/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XSP4M	GO:0003677	1/6	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8C2KQB	GO:0007018	2/5	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8C2KQB	GO:0001539	2/5	cilium or flagellum-dependent cell motility	biological_process	"Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc]
EOG8C2KQB	GO:0003777	2/5	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8C2KQB	GO:0030031	2/5	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG8C2KQB	GO:0030286	1/5	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8C2KQB	GO:0005524	1/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8C2KQB	GO:0016887	1/5	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG87SVV2	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87SVV2	GO:0004970	2/5	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG87SVV2	GO:0030054	2/5	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG87SVV2	GO:0005234	2/5	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG87SVV2	GO:0045211	2/5	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG86Q977	GO:0003993	1/4	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG8WQ3GJ	GO:0016491	7/50	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8WQ3GJ	GO:0005737	7/50	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WQ3GJ	GO:0004047	7/50	aminomethyltransferase activity	molecular_function	"Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10]
EOG8WQ3GJ	GO:0006546	7/50	glycine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]
EOG8XWJDF	GO:0003700	2/40	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8XWJDF	GO:0005634	2/40	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XWJDF	GO:0043565	2/40	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NZX7Q	GO:0006457	1/7	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8NZX7Q	GO:0003755	1/7	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG88WFHG	GO:0003735	24/65	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG88WFHG	GO:0006412	24/65	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG88WFHG	GO:0005840	23/65	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG88WFHG	GO:0005763	1/65	mitochondrial small ribosomal subunit	cellular_component	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
EOG86Q978	GO:0016787	2/5	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8NZX7J	GO:0016021	15/49	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NZX7J	GO:0055085	15/49	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG880MCH	GO:0016811	2/9	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]
EOG880MCH	GO:0006807	1/9	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG8WQ3GV	GO:0035556	5/17	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8WQ3GV	GO:0046872	5/17	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WQ3GV	GO:0038032	3/17	termination of G-protein coupled receptor signaling pathway	biological_process	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]
EOG8WQ3GV	GO:0005737	3/17	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WQ3GV	GO:0005089	3/17	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG88WFHT	GO:0005524	1/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8Z0DMS	GO:0006629	8/29	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8Z0DMS	GO:0005576	8/29	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Z0DMS	GO:0003824	7/29	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8Z0DMS	GO:0016787	1/29	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8Z0DMR	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z0DMR	GO:0003824	2/5	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8QC3KP	GO:0005234	18/135	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8QC3KP	GO:0004970	13/135	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8QC3KP	GO:0016020	12/135	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QC3KP	GO:0005215	9/135	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8QC3KP	GO:0015276	8/135	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8QC3KP	GO:0034220	8/135	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8QC3KP	GO:0009593	8/135	detection of chemical stimulus	biological_process	"The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
EOG8QC3KP	GO:0016021	8/135	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QC3KP	GO:0035235	5/135	ionotropic glutamate receptor signaling pathway	biological_process	"A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732]
EOG8QC3KP	GO:0030425	5/135	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8QC3KP	GO:0045211	5/135	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8QC3KP	GO:0035249	5/135	synaptic transmission, glutamatergic	biological_process	"The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv]
EOG8QC3KP	GO:0004971	3/135	AMPA glutamate receptor activity	molecular_function	"An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium." [GOC:mah, PMID:10049997, PMID:8804111]
EOG8QC3KP	GO:0032281	3/135	AMPA glutamate receptor complex	cellular_component	"An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef]
EOG8QC3KP	GO:0036081	3/135	extracellular ammonia-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
EOG8QC3KP	GO:0050909	2/135	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8QC3KP	GO:0008328	1/135	ionotropic glutamate receptor complex	cellular_component	"A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
EOG8QC3KP	GO:0017146	1/135	NMDA selective glutamate receptor complex	cellular_component	"An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
EOG8QC3KP	GO:0004972	1/135	NMDA glutamate receptor activity	molecular_function	"An ionotropic glutamate receptor activity that exhibits slow gating by glutamate, acts by opening a nonselective cation channel, and can be activated by L-aspartate." [GOC:mah, PMID:10049997]
EOG88PQ0N	GO:0009058	16/68	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG88PQ0N	GO:0030170	16/68	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG88PQ0N	GO:0003824	15/68	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG88PQ0N	GO:0008483	1/68	transaminase activity	molecular_function	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]
EOG8S7N52	GO:0004252	2/5	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG81C9C8	GO:0005509	2/5	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8P2SG1	GO:0005524	26/95	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8P2SG1	GO:0004674	23/95	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8P2SG1	GO:0004683	2/95	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG8P2SG1	GO:0006468	1/95	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8P2SG1	GO:0004672	1/95	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8P2SG1	GO:0016787	1/95	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8P2SG8	GO:0072686	1/45	mitotic spindle	cellular_component	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
EOG8P2SG8	GO:0008017	1/45	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8P2SG8	GO:0005634	1/45	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG844P06	GO:0016021	81/188	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG844P06	GO:0005524	81/188	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG844P06	GO:0042626	77/188	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG844P06	GO:0008559	6/188	xenobiotic-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44]
EOG844P06	GO:0031427	4/188	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG844P06	GO:0005886	4/188	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG844P06	GO:0055085	4/188	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG844P06	GO:0015440	2/188	peptide-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [EC:3.6.3.43]
EOG844P06	GO:0006855	2/188	drug transmembrane transport	biological_process	"The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:ai, GOC:bf]
EOG844P06	GO:0015238	1/188	drug transmembrane transporter activity	molecular_function	"Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [ISBN:0198506732]
EOG844P06	GO:0060857	1/188	establishment of glial blood-brain barrier	biological_process	"Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
EOG844P06	GO:0008354	1/188	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG844P06	GO:0042908	1/188	xenobiotic transport	biological_process	"The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
EOG844P06	GO:0001666	1/188	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG844P06	GO:0005919	1/188	pleated septate junction	cellular_component	"A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298]
EOG844P06	GO:0015562	1/188	efflux transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG844P06	GO:0043190	1/188	ATP-binding cassette (ABC) transporter complex	cellular_component	"A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107]
EOG844P06	GO:0005887	1/188	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8P5NQM	GO:0004519	1/5	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8P5NQM	GO:0003723	1/5	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8P5NQM	GO:0003964	1/5	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG805VH4	GO:0016491	1/3	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG844P09	GO:0016021	2/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG844P09	GO:0030100	1/96	regulation of endocytosis	biological_process	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]
EOG844P09	GO:0000281	1/96	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG844P09	GO:0016079	1/96	synaptic vesicle exocytosis	biological_process	"Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
EOG844P09	GO:0048488	1/96	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG844P09	GO:0007602	1/96	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG844P09	GO:0007268	1/96	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG844P09	GO:0045202	1/96	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8B8MT4	GO:0005524	21/88	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8B8MT4	GO:0017111	21/88	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8B8MT4	GO:0005634	1/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8B8MT4	GO:0003677	1/88	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8B8MT1	GO:0003676	17/78	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8B8MT1	GO:0008270	17/78	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8B8MT1	GO:0005634	17/78	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8B8MT1	GO:0046872	4/78	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8B8MT1	GO:0042023	1/78	DNA endoreduplication	biological_process	"Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw]
EOG8B8MT1	GO:0060968	1/78	regulation of gene silencing	biological_process	"Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb]
EOG8B8MT1	GO:0003677	1/78	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8B8MT1	GO:0006260	1/78	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8FXTPR	GO:0003677	17/116	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FXTPR	GO:0046872	4/116	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8FXTPR	GO:0003676	2/116	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FXTPD	GO:0016021	1/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FJBRW	GO:0016021	1/55	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FJBRW	GO:0004579	1/55	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	molecular_function	"Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119]
EOG8FJBRW	GO:0006486	1/55	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8FJBRW	GO:0005783	1/55	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8FJBRW	GO:0005739	1/55	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8B8MTT	GO:0019310	25/78	inositol catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, GOC:go_curators]
EOG8B8MTT	GO:0005506	25/78	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8B8MTT	GO:0005737	25/78	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8B8MTT	GO:0050113	25/78	inositol oxygenase activity	molecular_function	"Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+)." [EC:1.13.99.1, RHEA:23699]
EOG8SR09V	GO:0004869	1/4	cysteine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb]
EOG8B8MTR	GO:0005506	2/4	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8B8MTR	GO:0020037	2/4	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8B8MTR	GO:0016705	2/4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8B8MTR	GO:0004497	1/4	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8KPWVN	GO:0006030	1/4	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8KPWVN	GO:0008061	1/4	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8KPWVN	GO:0005576	1/4	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8KM1JS	GO:0016021	2/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KM1JS	GO:0005272	2/4	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8S7N5G	GO:0003676	3/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8S7N5G	GO:0046872	2/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8S7N5G	GO:0008270	1/6	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8S7N5G	GO:0005634	1/6	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8QC3K7	GO:0003676	24/98	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QC3K7	GO:0005524	24/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QC3K7	GO:0008026	19/98	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8QC3K7	GO:0004386	4/98	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8QC3K7	GO:0006200	1/98	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8QC3K7	GO:0000398	1/98	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8QC3K7	GO:0002121	1/98	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8QC3K7	GO:0005681	1/98	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8QC3K7	GO:0000381	1/98	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8QC3K7	GO:0004004	1/98	ATP-dependent RNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8QC3K7	GO:0006810	1/98	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8QC3K7	GO:0007476	1/98	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8TB6V3	GO:0030695	14/52	GTPase regulator activity	molecular_function	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
EOG8SR0B4	GO:0046872	2/8	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8SR0B3	GO:0003707	25/92	steroid hormone receptor activity	molecular_function	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
EOG8SR0B3	GO:0005634	25/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SR0B3	GO:0006351	24/92	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8SR0B3	GO:0003700	24/92	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8SR0B3	GO:0008270	23/92	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SR0B3	GO:0043565	22/92	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8SR0B3	GO:0003677	1/92	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8SR0B3	GO:0016321	1/92	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8SR0B3	GO:0035211	1/92	spermathecum morphogenesis	biological_process	"The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097]
EOG8SR0B3	GO:0030522	1/92	intracellular receptor signaling pathway	biological_process	"Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah]
EOG8SR0B3	GO:0006919	1/92	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
EOG8SR0B3	GO:0060968	1/92	regulation of gene silencing	biological_process	"Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb]
EOG8SR0B3	GO:0005515	1/92	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8SR0B3	GO:0045433	1/92	male courtship behavior, veined wing generated song production	biological_process	"The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
EOG8SR0B3	GO:0000978	1/92	RNA polymerase II core promoter proximal region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II." [GOC:txnOH]
EOG8SR0B3	GO:0004879	1/92	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	molecular_function	"Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH]
EOG8SR0B3	GO:0035072	1/92	ecdysone-mediated induction of salivary gland cell autophagic cell death	biological_process	"Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis." [GOC:bf]
EOG8K9DVG	GO:0042073	1/100	intraciliary transport	biological_process	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374]
EOG8K9DVG	GO:0000922	1/100	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8K9DVG	GO:0005875	1/100	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8K9DVG	GO:0005515	1/100	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8K9DVG	GO:0000242	1/100	pericentriolar material	cellular_component	"A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]
EOG8K9DVG	GO:0007279	1/100	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8K9DVG	GO:0005813	1/100	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8K9DVG	GO:0008017	1/100	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8K9DVG	GO:0000235	1/100	astral microtubule	cellular_component	"Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194]
EOG8K9DVG	GO:0007143	1/100	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8K9DVG	GO:0007067	1/100	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8K9DVG	GO:0007097	1/100	nuclear migration	biological_process	"The directed movement of the nucleus." [GOC:ai]
EOG8K9DVG	GO:0007344	1/100	pronuclear fusion	biological_process	"The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X]
EOG8K9DVG	GO:0008104	1/100	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8K9DVG	GO:0005876	1/100	spindle microtubule	cellular_component	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]
EOG8K9DVG	GO:0007052	1/100	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8K9DVG	GO:0007026	1/100	negative regulation of microtubule depolymerization	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]
EOG8K9DVG	GO:0000226	1/100	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8K9DVG	GO:0035046	1/100	pronuclear migration	biological_process	"The directed movement of the male and female pronuclei towards each other prior to their fusion." [GOC:bf, PMID:9199363]
EOG8XKXQB	GO:0005549	3/6	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8SFCMP	GO:0016705	2/6	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8SFCMP	GO:0020037	2/6	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8SFCMP	GO:0005506	2/6	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG83BQ30	GO:0005524	1/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG83BQ30	GO:0016887	1/5	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG825876	GO:0046872	26/78	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG825876	GO:0003676	25/78	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WM795	GO:0003677	2/6	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8HHRHG	GO:0016021	111/321	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HHRHG	GO:0055085	111/321	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8HHRHG	GO:0008260	2/321	3-oxoacid CoA-transferase activity	molecular_function	"Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [EC:2.8.3.5]
EOG8HHRHG	GO:0005886	1/321	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8HHRHG	GO:0005215	1/321	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8HHRHG	GO:0006171	1/321	cAMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]
EOG8HHRHG	GO:0004016	1/321	adenylate cyclase activity	molecular_function	"Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]
EOG8BCH3W	GO:0010506	1/87	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8BCH3W	GO:0006914	1/87	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG8BCH3W	GO:0034273	1/87	ATG1/UKL1 kinase complex	cellular_component	"A protein complex consisting of ATG1/UKL1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, IntAct:EBI-2352849, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]
EOG8BCH3W	GO:0005829	1/87	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8BCH3W	GO:0000407	1/87	pre-autophagosomal structure	cellular_component	"A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]
EOG8MGVN5	GO:0046872	1/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8MGVN5	GO:0016491	1/6	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8MGVN5	GO:0051537	1/6	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8BZQHZ	GO:0005622	1/7	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8BZQHZ	GO:0005215	1/7	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8QRKMX	GO:0003676	1/3	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82587N	GO:0046872	3/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82587N	GO:0003676	3/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88D390	GO:0008898	1/6	S-adenosylmethionine-homocysteine S-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10, GOC:BHF, GOC:dph]
EOG85B3VV	GO:0000062	23/86	fatty-acyl-CoA binding	molecular_function	"Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732]
EOG85B3VV	GO:0016021	22/86	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85B3VV	GO:0006810	22/86	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG85B3VH	GO:0008270	14/53	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG85B3VH	GO:0016874	1/53	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG83BQ3N	GO:0006950	2/33	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG80ZTFM	GO:0007409	1/126	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG80ZTFM	GO:0022008	1/126	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG83BQ3C	GO:0003676	2/14	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83BQ3C	GO:0046872	2/14	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83BQ3C	GO:0016887	1/14	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG83BQ3C	GO:0005524	1/14	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VX4K4	GO:0005576	4/62	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8VX4K4	GO:0042742	3/62	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8VX4K4	GO:0007498	1/62	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8VX4K4	GO:0009405	1/62	pathogenesis	biological_process	"The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators]
EOG87Q0M6	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VX4K1	GO:0005524	1/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VX4K1	GO:0005044	1/98	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8VX4K1	GO:0044267	1/98	cellular protein metabolic process	biological_process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]
EOG8VX4K1	GO:0016020	1/98	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG87Q0M0	GO:0016020	1/4	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8MPM5B	GO:0051213	3/57	dioxygenase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf, http://www.onelook.com/]
EOG8MPM5B	GO:0048244	2/57	phytanoyl-CoA dioxygenase activity	molecular_function	"Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate." [EC:1.14.11.18, RHEA:16068]
EOG879HNZ	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG879HNZ	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8P2SJ4	GO:0042626	2/5	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8V71WH	GO:0007155	30/104	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8V71WH	GO:0005198	30/104	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8V71WH	GO:0015629	30/104	actin cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
EOG8V71WH	GO:0008092	1/104	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8V71WH	GO:0016342	1/104	catenin complex	cellular_component	"Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323]
EOG8V71WH	GO:0007016	1/104	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG8V71WH	GO:0005737	1/104	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8V71WH	GO:0030720	1/104	oocyte localization involved in germarium-derived egg chamber formation	biological_process	"Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356]
EOG8V71WH	GO:0060323	1/104	head morphogenesis	biological_process	"The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph]
EOG8V71WH	GO:0003779	1/104	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8V71WH	GO:0005886	1/104	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8V71WH	GO:0034332	1/104	adherens junction organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah]
EOG8V71WH	GO:0005914	1/104	spot adherens junction	cellular_component	"A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298]
EOG8V71WH	GO:0005912	1/104	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8V71WH	GO:0007163	1/104	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8V71WH	GO:0005515	1/104	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8V71WH	GO:0005913	1/104	cell-cell adherens junction	cellular_component	"An adherens junction which connects a cell to another cell." [GOC:hb]
EOG8V71WH	GO:0005915	1/104	zonula adherens	cellular_component	"A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208]
EOG8R268M	GO:0006108	4/9	malate metabolic process	biological_process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]
EOG8R268M	GO:0016615	4/9	malate dehydrogenase activity	molecular_function	"Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]
EOG8R268M	GO:0016616	3/9	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8R268M	GO:0005975	3/9	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8NW221	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NW221	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W3W41	GO:0003735	21/63	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8W3W41	GO:0005840	21/63	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8W3W41	GO:0006412	21/63	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8R268S	GO:0016021	3/8	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8R268S	GO:0022857	3/8	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8G1Q0V	GO:0007229	1/11	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG8R268W	GO:0016787	2/4	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8R268W	GO:0006629	2/4	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8R268W	GO:0005576	2/4	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8R2688	GO:0016021	1/3	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8R2689	GO:0008270	25/78	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8R2689	GO:0003676	4/78	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VX4KT	GO:0009058	14/44	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG8VX4KT	GO:0016740	1/44	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8VX4KT	GO:0016757	1/44	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG87Q0MQ	GO:0016616	4/47	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG87Q0MQ	GO:0044262	3/47	cellular carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
EOG87Q0MQ	GO:0005975	1/47	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8V19GB	GO:0008270	5/50	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V19GB	GO:0005524	2/50	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87Q0MR	GO:0004497	2/4	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG87Q0MR	GO:0020037	2/4	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG87Q0MR	GO:0016705	2/4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG87Q0MR	GO:0005506	2/4	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG80KBD0	GO:0050660	5/37	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG80KBD0	GO:0006066	4/37	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG80KBD0	GO:0008812	4/37	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG80KBD0	GO:0016614	1/37	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8VX4KB	GO:0016324	1/216	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8VX4KB	GO:0005080	1/216	protein kinase C binding	molecular_function	"Interacting selectively and non-covalently with protein kinase C." [GOC:jl]
EOG8VX4KB	GO:0008594	1/216	photoreceptor cell morphogenesis	biological_process	"The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
EOG8VX4KB	GO:0002009	1/216	morphogenesis of an epithelium	biological_process	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
EOG8VX4KB	GO:0035088	1/216	establishment or maintenance of apical/basal cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483]
EOG8VX4KB	GO:0016333	1/216	morphogenesis of follicular epithelium	biological_process	"The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl]
EOG8VX4KB	GO:0016334	1/216	establishment or maintenance of polarity of follicular epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah]
EOG8VX4KB	GO:0035509	1/216	negative regulation of myosin-light-chain-phosphatase activity	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators]
EOG8VX4KB	GO:0005737	1/216	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8VX4KB	GO:0032033	1/216	myosin II light chain binding	molecular_function	"Interacting selectively and non-covalently with a light chain of a myosin II complex." [GOC:mah]
EOG8VX4KB	GO:0005886	1/216	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8VX4KB	GO:0045176	1/216	apical protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf]
EOG8VX4KB	GO:0005918	1/216	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG8VX4KB	GO:0034332	1/216	adherens junction organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah]
EOG8VX4KB	GO:0001736	1/216	establishment of planar polarity	biological_process	"Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
EOG8VX4KB	GO:0016332	1/216	establishment or maintenance of polarity of embryonic epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah]
EOG8VX4KB	GO:0045494	1/216	photoreceptor cell maintenance	biological_process	"Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]
EOG8VX4KB	GO:0005635	1/216	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG8VX4KB	GO:0007163	1/216	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8VX4KB	GO:0035209	1/216	pupal development	biological_process	"The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis." [GOC:bf, GOC:mtg_sensu]
EOG8VX4KB	GO:0005515	1/216	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VX4KB	GO:0016327	1/216	apicolateral plasma membrane	cellular_component	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
EOG8VX4KB	GO:0035003	1/216	subapical complex	cellular_component	"The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938]
EOG8VX4KB	GO:0005875	1/216	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8VX4KB	GO:0007043	1/216	cell-cell junction assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai]
EOG8VX4KB	GO:0005912	1/216	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8VX4KB	GO:0045179	1/216	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8VX4KB	GO:0034334	1/216	adherens junction maintenance	biological_process	"The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah]
EOG8VX4KB	GO:0045186	1/216	zonula adherens assembly	biological_process	"Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf]
EOG8JMB66	GO:0008233	1/3	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8WDGSZ	GO:0004252	2/6	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]