GO:0003964 RNA-directed DNA polymerase activity Gains GO:0034061 DNA polymerase activity Gains GO:0140097 catalytic activity, acting on DNA Gains GO:0016779 nucleotidyltransferase activity Gains GO:0046914 transition metal ion binding Gains GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen Gains GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Gains GO:0043169 cation binding Gains GO:0008010 structural constituent of chitin-based larval cuticle Gains GO:0008270 zinc ion binding Gains GO:0046872 metal ion binding Gains GO:0020037 heme binding Gains GO:0004190 aspartic-type endopeptidase activity Gains GO:0070001 aspartic-type peptidase activity Gains GO:0046906 tetrapyrrole binding Gains GO:0005214 structural constituent of chitin-based cuticle Gains GO:0004497 monooxygenase activity Gains GO:0042834 peptidoglycan binding Gains GO:0018685 alkane 1-monooxygenase activity Gains GO:0005212 structural constituent of eye lens Gains GO:0008011 structural constituent of pupal chitin-based cuticle Gains GO:0005272 sodium channel activity Gains GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Gains GO:0050660 flavin adenine dinucleotide binding Gains GO:0042302 structural constituent of cuticle Gains GO:0030246 carbohydrate binding Gains GO:0004519 endonuclease activity Gains GO:0097642 calcitonin family receptor activity Gains GO:0004948 calcitonin receptor activity Gains GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity Gains GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity Gains GO:0052739 phosphatidylserine 1-acylhydrolase activity Gains GO:0008036 diuretic hormone receptor activity Gains GO:0008970 phosphatidylcholine 1-acylhydrolase activity Gains GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds Gains GO:0005506 iron ion binding Gains GO:0004518 nuclease activity Gains GO:0008061 chitin binding Gains GO:0032403 protein complex binding Gains GO:0016788 hydrolase activity, acting on ester bonds Gains GO:0035250 UDP-galactosyltransferase activity Gains GO:0038187 pattern recognition receptor activity Gains GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity Gains GO:0008329 signaling pattern recognition receptor activity Gains GO:0033549 MAP kinase phosphatase activity Gains GO:0045289 luciferin monooxygenase activity Gains GO:0015081 sodium ion transmembrane transporter activity Gains GO:0016491 oxidoreductase activity Gains GO:0016798 hydrolase activity, acting on glycosyl bonds Gains GO:0048037 cofactor binding Gains GO:0016215 acyl-CoA desaturase activity Gains GO:0016703 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) Gains GO:0004768 stearoyl-CoA 9-desaturase activity Gains GO:0015077 monovalent inorganic cation transmembrane transporter activity Gains GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Gains GO:0050662 coenzyme binding Gains GO:0044877 macromolecular complex binding Gains GO:0008378 galactosyltransferase activity Gains GO:0004016 adenylate cyclase activity Gains GO:0004180 carboxypeptidase activity Gains GO:0004806 triglyceride lipase activity Gains GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Gains GO:0008762 UDP-N-acetylmuramate dehydrogenase activity Gains GO:0005245 voltage-gated calcium channel activity Gains GO:0070330 aromatase activity Gains GO:0008188 neuropeptide receptor activity Gains GO:0016772 transferase activity, transferring phosphorus-containing groups Gains GO:0022890 inorganic cation transmembrane transporter activity Gains GO:0052689 carboxylic ester hydrolase activity Gains GO:0015299 solute:proton antiporter activity Gains GO:0004089 carbonate dehydratase activity Gains GO:0008395 steroid hydroxylase activity Gains GO:0030165 PDZ domain binding Gains GO:0003676 nucleic acid binding Gains GO:0015280 ligand-gated sodium channel activity Gains GO:0004096 catalase activity Gains GO:0004097 catechol oxidase activity Gains GO:0032500 muramyl dipeptide binding Gains GO:0010461 light-activated ion channel activity Gains GO:0004068 aspartate 1-decarboxylase activity Gains GO:0004055 argininosuccinate synthase activity Gains GO:0010420 polyprenyldihydroxybenzoate methyltransferase activity Gains GO:0018833 DDT-dehydrochlorinase activity Gains GO:0044736 acid-sensing ion channel activity Gains GO:0017061 S-methyl-5-thioadenosine phosphorylase activity Gains GO:0004946 bombesin receptor activity Gains GO:0008331 high voltage-gated calcium channel activity Gains GO:0001082 transcription factor activity, RNA polymerase I transcription factor binding Gains GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity Gains GO:0001046 core promoter sequence-specific DNA binding Gains GO:0008456 alpha-N-acetylgalactosaminidase activity Gains GO:0016160 amylase activity Gains GO:0030342 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity Gains GO:0004395 hexaprenyldihydroxybenzoate methyltransferase activity Gains GO:0004351 glutamate decarboxylase activity Gains GO:0031473 myosin III binding Gains GO:0004321 fatty-acyl-CoA synthase activity Gains GO:0052869 arachidonic acid omega-hydroxylase activity Gains GO:0052870 tocopherol omega-hydroxylase activity Gains GO:0052871 alpha-tocopherol omega-hydroxylase activity Gains GO:0016231 beta-N-acetylglucosaminidase activity Gains GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity Gains GO:0004466 long-chain-acyl-CoA dehydrogenase activity Gains GO:0050051 leukotriene-B4 20-monooxygenase activity Gains GO:0070576 vitamin D 24-hydroxylase activity Gains GO:0004167 dopachrome isomerase activity Gains GO:0052692 raffinose alpha-galactosidase activity Gains GO:0042768 ecdysteroid 2-hydroxylase activity Gains GO:0008747 N-acetylneuraminate lyase activity Gains GO:0001164 RNA polymerase I CORE element sequence-specific DNA binding Gains GO:0001167 RNA polymerase I transcription factor activity, sequence-specific DNA binding Gains GO:0008801 beta-phosphoglucomutase activity Gains GO:0001169 transcription factor activity, RNA polymerase I CORE element sequence-specific binding Gains GO:0036263 L-DOPA monooxygenase activity Gains GO:0036264 dopamine monooxygenase activity Gains GO:0001186 transcription factor activity, RNA polymerase I transcription factor recruiting Gains GO:0001187 transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting Gains GO:0004796 thromboxane-A synthase activity Gains GO:0042806 fucose binding Gains GO:0001134 transcription factor activity, transcription factor recruiting Gains GO:0004782 sulfinoalanine decarboxylase activity Gains GO:0032183 SUMO binding Gains GO:0001222 transcription corepressor binding Gains GO:0001226 RNA polymerase II transcription corepressor binding Gains GO:0047880 erythrulose reductase activity Gains GO:0008689 3-demethylubiquinone-9 3-O-methyltransferase activity Gains GO:0004556 alpha-amylase activity Gains GO:0004557 alpha-galactosidase activity Gains GO:0061542 3-demethylubiquinone-n 3-O-methyltransferase activity Gains GO:0004517 nitric-oxide synthase activity Gains GO:0035013 myosuppressin receptor activity Gains GO:0001875 lipopolysaccharide receptor activity Gains GO:0016019 peptidoglycan receptor activity Gains GO:0004666 prostaglandin-endoperoxide synthase activity Gains GO:0008086 light-activated voltage-gated calcium channel activity Gains GO:0003700 DNA binding transcription factor activity Gains GO:0016758 transferase activity, transferring hexosyl groups Gains GO:0003995 acyl-CoA dehydrogenase activity Gains GO:0016684 oxidoreductase activity, acting on peroxide as acceptor Gains GO:0005516 calmodulin binding Gains GO:0005539 glycosaminoglycan binding Gains GO:0004601 peroxidase activity Gains GO:0005488 binding Gains GO:0008238 exopeptidase activity Gains GO:0005261 cation channel activity Gains GO:0004687 myosin light chain kinase activity Losses GO:0016798 hydrolase activity, acting on glycosyl bonds Losses GO:0004935 adrenergic receptor activity Losses GO:0046332 SMAD binding Losses GO:0015245 fatty acid transporter activity Losses GO:0070410 co-SMAD binding Losses GO:0035368 selenocysteine insertion sequence binding Losses GO:0015204 urea transmembrane transporter activity Losses GO:0005009 insulin-activated receptor activity Losses GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity Losses GO:0045552 dihydrokaempferol 4-reductase activity Losses GO:0008496 mannan endo-1,6-alpha-mannosidase activity Losses GO:0033867 Fas-activated serine/threonine kinase activity Losses GO:0035184 histone threonine kinase activity Losses GO:0000016 lactase activity Losses GO:0043916 DNA-7-methylguanine glycosylase activity Losses GO:0005324 long-chain fatty acid transporter activity Losses GO:0047326 inositol tetrakisphosphate 5-kinase activity Losses GO:0052821 DNA-7-methyladenine glycosylase activity Losses GO:0052822 DNA-3-methylguanine glycosylase activity Losses GO:0016785 transferase activity, transferring selenium-containing groups Losses GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity Losses GO:0050080 malonyl-CoA decarboxylase activity Losses GO:0008725 DNA-3-methyladenine glycosylase activity Losses GO:0004131 cytosine deaminase activity Losses GO:0030785 [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity Losses GO:0004769 steroid delta-isomerase activity Losses GO:0047747 cholate-CoA ligase activity Losses GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process Losses GO:0051425 PTB domain binding Losses GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis Losses GO:0001735 prenylcysteine oxidase activity Losses GO:0043733 DNA-3-methylbase glycosylase activity Losses GO:0003919 FMN adenylyltransferase activity Losses GO:0003905 alkylbase DNA N-glycosylase activity Losses GO:0000823 inositol-1,4,5-trisphosphate 6-kinase activity Losses GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity Losses GO:0043560 insulin receptor substrate binding Losses GO:0043559 insulin binding Losses GO:0004970 ionotropic glutamate receptor activity Losses GO:0022824 transmitter-gated ion channel activity Losses GO:0022835 transmitter-gated channel activity Losses GO:0004167 dopachrome isomerase activity Novel expansions GO:0015077 monovalent inorganic cation transmembrane transporter activity Novel expansions GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds Novel expansions GO:0022890 inorganic cation transmembrane transporter activity Novel expansions GO:0005215 transporter activity Novel expansions GO:0005272 sodium channel activity Novel expansions GO:0008324 cation transmembrane transporter activity Novel expansions GO:0004177 aminopeptidase activity Novel expansions GO:0019205 nucleobase-containing compound kinase activity Novel expansions GO:0004687 myosin light chain kinase activity Extinctions GO:0004970 ionotropic glutamate receptor activity Extinctions GO:0022824 transmitter-gated ion channel activity Extinctions GO:0022835 transmitter-gated channel activity Extinctions GO:0035368 selenocysteine insertion sequence binding Extinctions GO:0015204 urea transmembrane transporter activity Extinctions GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity Extinctions GO:0045552 dihydrokaempferol 4-reductase activity Extinctions GO:0008496 mannan endo-1,6-alpha-mannosidase activity Extinctions GO:0033867 Fas-activated serine/threonine kinase activity Extinctions GO:0000016 lactase activity Extinctions GO:0043916 DNA-7-methylguanine glycosylase activity Extinctions GO:0047326 inositol tetrakisphosphate 5-kinase activity Extinctions GO:0052821 DNA-7-methyladenine glycosylase activity Extinctions GO:0052822 DNA-3-methylguanine glycosylase activity Extinctions GO:0016785 transferase activity, transferring selenium-containing groups Extinctions GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity Extinctions GO:0050080 malonyl-CoA decarboxylase activity Extinctions GO:0008725 DNA-3-methyladenine glycosylase activity Extinctions GO:0004769 steroid delta-isomerase activity Extinctions GO:0001735 prenylcysteine oxidase activity Extinctions GO:0043733 DNA-3-methylbase glycosylase activity Extinctions GO:0003905 alkylbase DNA N-glycosylase activity Extinctions GO:0000823 inositol-1,4,5-trisphosphate 6-kinase activity Extinctions GO:0005234 extracellularly glutamate-gated ion channel activity Extinctions GO:0005231 excitatory extracellular ligand-gated ion channel activity Extinctions GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds Extinctions GO:0008066 glutamate receptor activity Extinctions