GO:0020037	heme binding	Gains
GO:0046906	tetrapyrrole binding	Gains
GO:0050660	flavin adenine dinucleotide binding	Gains
GO:0009055	electron transfer activity	Gains
GO:0050662	coenzyme binding	Gains
GO:0051213	dioxygenase activity	Gains
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
GO:0016783	sulfurtransferase activity	Gains
GO:0048037	cofactor binding	Gains
GO:0003995	acyl-CoA dehydrogenase activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0003991	acetylglutamate kinase activity	Gains
GO:0003942	N-acetyl-gamma-glutamyl-phosphate reductase activity	Gains
GO:0031071	cysteine desulfurase activity	Gains
GO:0004060	arylamine N-acetyltransferase activity	Gains
GO:0004059	aralkylamine N-acetyltransferase activity	Gains
GO:0043992	histone acetyltransferase activity (H3-K9 specific)	Gains
GO:0030366	molybdopterin synthase activity	Gains
GO:0043914	NADPH:sulfur oxidoreductase activity	Gains
GO:0072320	volume-sensitive chloride channel activity	Gains
GO:0004362	glutathione-disulfide reductase activity	Gains
GO:0004339	glucan 1,4-alpha-glucosidase activity	Gains
GO:0042767	ecdysteroid 22-hydroxylase activity	Gains
GO:0008781	N-acylneuraminate cytidylyltransferase activity	Gains
GO:0005225	volume-sensitive anion channel activity	Gains
GO:0008811	chloramphenicol O-acetyltransferase activity	Gains
GO:0004791	thioredoxin-disulfide reductase activity	Gains
GO:0050661	NADP binding	Gains
GO:0046873	metal ion transmembrane transporter activity	Gains
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Gains
GO:0016491	oxidoreductase activity	Gains
GO:0022890	inorganic cation transmembrane transporter activity	Gains
GO:0034647	histone demethylase activity (H3-trimethyl-K4 specific)	Gains
GO:0004833	tryptophan 2,3-dioxygenase activity	Gains
GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Gains
GO:0004801	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	Gains
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	Gains
GO:0004501	ecdysone 20-monooxygenase activity	Gains
GO:0003945	N-acetyllactosamine synthase activity	Gains
GO:0004018	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	Gains
GO:0045505	dynein intermediate chain binding	Gains
GO:0043958	acryloyl-CoA reductase activity	Gains
GO:0008470	isovaleryl-CoA dehydrogenase activity	Gains
GO:0008475	procollagen-lysine 5-dioxygenase activity	Gains
GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Gains
GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Gains
GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Gains
GO:0005391	sodium:potassium-exchanging ATPase activity	Gains
GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Gains
GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Gains
GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Gains
GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Gains
GO:0004345	glucose-6-phosphate dehydrogenase activity	Gains
GO:0004335	galactokinase activity	Gains
GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Gains
GO:0015037	peptide disulfide oxidoreductase activity	Gains
GO:0015038	glutathione disulfide oxidoreductase activity	Gains
GO:0070626	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity	Gains
GO:0005200	structural constituent of cytoskeleton	Gains
GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Gains
GO:0015926	glucosidase activity	Losses
GO:0032450	maltose alpha-glucosidase activity	Losses
GO:0090599	alpha-glucosidase activity	Losses
GO:0042834	peptidoglycan binding	Losses
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
GO:0005212	structural constituent of eye lens	Losses
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Losses
GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0022857	transmembrane transporter activity	Losses
GO:0005215	transporter activity	Losses
GO:0008233	peptidase activity	Losses
GO:0008613	diuretic hormone activity	Losses
GO:0005000	vasopressin receptor activity	Losses
GO:0099600	transmembrane receptor activity	Losses
GO:0004181	metallocarboxypeptidase activity	Losses
GO:0061783	peptidoglycan muralytic activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0008528	G-protein coupled peptide receptor activity	Losses
GO:0001653	peptide receptor activity	Losses
GO:0050254	rhodopsin kinase activity	Losses
GO:0004180	carboxypeptidase activity	Losses
GO:0005184	neuropeptide hormone activity	Losses
GO:0004888	transmembrane signaling receptor activity	Losses
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Losses
GO:0004871	signal transducer activity	Losses
GO:0004872	receptor activity	Losses
GO:0005179	hormone activity	Losses
GO:0038023	signaling receptor activity	Losses
GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
GO:0005509	calcium ion binding	Losses
GO:0060089	molecular transducer activity	Losses
GO:0008237	metallopeptidase activity	Losses
GO:0005539	glycosaminoglycan binding	Losses
GO:0046914	transition metal ion binding	Losses
GO:0001664	G-protein coupled receptor binding	Losses
GO:0008235	metalloexopeptidase activity	Losses
GO:0004930	G-protein coupled receptor activity	Losses
GO:0004175	endopeptidase activity	Losses
GO:0005549	odorant binding	Losses
GO:0048018	receptor ligand activity	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0005230	extracellular ligand-gated ion channel activity	Losses
GO:0061778	intracellular chloride channel activity	Losses
GO:0031544	peptidyl-proline 3-dioxygenase activity	Losses
GO:0004846	urate oxidase activity	Losses
GO:0016019	peptidoglycan receptor activity	Losses
GO:0001875	lipopolysaccharide receptor activity	Losses
GO:0015438	teichoic-acid-transporting ATPase activity	Losses
GO:0019797	procollagen-proline 3-dioxygenase activity	Losses
GO:0015162	teichoic acid transmembrane transporter activity	Losses
GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
GO:0032813	tumor necrosis factor receptor superfamily binding	Losses
GO:0015175	neutral amino acid transmembrane transporter activity	Losses
GO:0001586	Gi/o-coupled serotonin receptor activity	Losses
GO:0015142	tricarboxylic acid transmembrane transporter activity	Losses
GO:0015137	citrate transmembrane transporter activity	Losses
GO:0042943	D-amino acid transmembrane transporter activity	Losses
GO:0042947	glucoside transmembrane transporter activity	Losses
GO:0008940	nitrate reductase activity	Losses
GO:0015222	serotonin transmembrane transporter activity	Losses
GO:0019811	cocaine binding	Losses
GO:0032500	muramyl dipeptide binding	Losses
GO:0045735	nutrient reservoir activity	Losses
GO:0004061	arylformamidase activity	Losses
GO:0050700	CARD domain binding	Losses
GO:0004971	AMPA glutamate receptor activity	Losses
GO:0004946	bombesin receptor activity	Losses
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
GO:0015574	trehalose transmembrane transporter activity	Losses
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Losses
GO:0008191	metalloendopeptidase inhibitor activity	Losses
GO:0005329	dopamine transmembrane transporter activity	Losses
GO:0052729	dimethylglycine N-methyltransferase activity	Losses
GO:0052730	sarcosine N-methyltransferase activity	Losses
GO:0004321	fatty-acyl-CoA synthase activity	Losses
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Losses
GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Losses
GO:0005164	tumor necrosis factor receptor binding	Losses
GO:0009703	nitrate reductase (NADH) activity	Losses
GO:0017174	glycine N-methyltransferase activity	Losses
GO:0005229	intracellular calcium activated chloride channel activity	Losses
GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Losses
GO:0004760	serine-pyruvate transaminase activity	Losses
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
GO:0030545	receptor regulator activity	Losses
GO:0022891	substrate-specific transmembrane transporter activity	Losses
GO:0004497	monooxygenase activity	Losses
GO:0016491	oxidoreductase activity	Losses
GO:0004568	chitinase activity	Losses
GO:0008010	structural constituent of chitin-based larval cuticle	Losses
GO:0004984	olfactory receptor activity	Losses
GO:0022892	substrate-specific transporter activity	Losses
GO:0015276	ligand-gated ion channel activity	Losses
GO:0022834	ligand-gated channel activity	Losses
GO:0043169	cation binding	Losses
GO:0046943	carboxylic acid transmembrane transporter activity	Losses
GO:0005342	organic acid transmembrane transporter activity	Losses
GO:0004970	ionotropic glutamate receptor activity	Novel expansions
GO:0022824	transmitter-gated ion channel activity	Novel expansions
GO:0022835	transmitter-gated channel activity	Novel expansions
GO:0005234	extracellularly glutamate-gated ion channel activity	Novel expansions
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Novel expansions
GO:0008066	glutamate receptor activity	Novel expansions
GO:0030594	neurotransmitter receptor activity	Novel expansions
GO:0005230	extracellular ligand-gated ion channel activity	Novel expansions
GO:0015276	ligand-gated ion channel activity	Novel expansions
GO:0022834	ligand-gated channel activity	Novel expansions
GO:0022836	gated channel activity	Novel expansions
GO:0004842	ubiquitin-protein transferase activity	Novel expansions
GO:0019787	ubiquitin-like protein transferase activity	Novel expansions
GO:0005216	ion channel activity	Novel expansions
GO:0022838	substrate-specific channel activity	Novel expansions
GO:0015267	channel activity	Novel expansions
GO:0022803	passive transmembrane transporter activity	Novel expansions
GO:0008613	diuretic hormone activity	Extinctions
GO:0005184	neuropeptide hormone activity	Extinctions
GO:0005179	hormone activity	Extinctions
GO:0001664	G-protein coupled receptor binding	Extinctions
GO:0032450	maltose alpha-glucosidase activity	Extinctions
GO:0048018	receptor ligand activity	Extinctions
GO:0090599	alpha-glucosidase activity	Extinctions
GO:0030545	receptor regulator activity	Extinctions
GO:0005506	iron ion binding	Extinctions
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0034061	DNA polymerase activity	Extinctions
GO:0005509	calcium ion binding	Extinctions
GO:0031544	peptidyl-proline 3-dioxygenase activity	Extinctions
GO:0004846	urate oxidase activity	Extinctions
GO:0015438	teichoic-acid-transporting ATPase activity	Extinctions
GO:0019797	procollagen-proline 3-dioxygenase activity	Extinctions
GO:0015162	teichoic acid transmembrane transporter activity	Extinctions
GO:0032813	tumor necrosis factor receptor superfamily binding	Extinctions
GO:0004061	arylformamidase activity	Extinctions
GO:0050700	CARD domain binding	Extinctions
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Extinctions
GO:0008191	metalloendopeptidase inhibitor activity	Extinctions
GO:0052729	dimethylglycine N-methyltransferase activity	Extinctions
GO:0052730	sarcosine N-methyltransferase activity	Extinctions
GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Extinctions
GO:0005164	tumor necrosis factor receptor binding	Extinctions
GO:0017174	glycine N-methyltransferase activity	Extinctions
GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Extinctions
GO:0004760	serine-pyruvate transaminase activity	Extinctions
GO:0015926	glucosidase activity	Extinctions
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Extinctions
GO:0070001	aspartic-type peptidase activity	Extinctions
GO:0004190	aspartic-type endopeptidase activity	Extinctions
GO:0004175	endopeptidase activity	Extinctions
GO:0018492	carbon-monoxide dehydrogenase (acceptor) activity	Extinctions
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Extinctions
GO:0051537	2 iron, 2 sulfur cluster binding	Extinctions
GO:0016779	nucleotidyltransferase activity	Extinctions