GO:0003964 RNA-directed DNA polymerase activity Gains GO:0034061 DNA polymerase activity Gains GO:0005549 odorant binding Gains GO:0016779 nucleotidyltransferase activity Gains GO:0003990 acetylcholinesterase activity Gains GO:0004104 cholinesterase activity Gains GO:0022857 transmembrane transporter activity Gains GO:0005215 transporter activity Gains GO:0015114 phosphate ion transmembrane transporter activity Gains GO:1901677 phosphate transmembrane transporter activity Gains GO:0004344 glucose dehydrogenase activity Gains GO:0008812 choline dehydrogenase activity Gains GO:0015926 glucosidase activity Gains GO:0140097 catalytic activity, acting on DNA Gains GO:0004857 enzyme inhibitor activity Gains GO:0015103 inorganic anion transmembrane transporter activity Gains GO:0050824 water binding Gains GO:0050825 ice binding Gains GO:0015321 sodium-dependent phosphate transmembrane transporter activity Gains GO:0008447 L-ascorbate oxidase activity Gains GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity Gains GO:0019992 diacylglycerol binding Gains GO:0032450 maltose alpha-glucosidase activity Gains GO:0090599 alpha-glucosidase activity Gains GO:0046914 transition metal ion binding Gains GO:0008329 signaling pattern recognition receptor activity Gains GO:0015232 heme transporter activity Gains GO:0038187 pattern recognition receptor activity Gains GO:0005501 retinoid binding Gains GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor Gains GO:0004549 tRNA-specific ribonuclease activity Gains GO:0004984 olfactory receptor activity Gains GO:0042302 structural constituent of cuticle Gains GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors Gains GO:0008270 zinc ion binding Gains GO:0004519 endonuclease activity Gains GO:0004930 G-protein coupled receptor activity Gains GO:0015293 symporter activity Gains GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Gains GO:0008745 N-acetylmuramoyl-L-alanine amidase activity Gains GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Gains GO:0030291 protein serine/threonine kinase inhibitor activity Gains GO:0022803 passive transmembrane transporter activity Losses GO:0015267 channel activity Losses GO:0005215 transporter activity Losses GO:0005216 ion channel activity Losses GO:0022838 substrate-specific channel activity Losses GO:0022857 transmembrane transporter activity Losses GO:0004560 alpha-L-fucosidase activity Losses GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds Losses GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances Losses GO:0015928 fucosidase activity Losses GO:0005261 cation channel activity Losses GO:0004457 lactate dehydrogenase activity Losses GO:0031419 cobalamin binding Losses GO:0038023 signaling receptor activity Losses GO:0022891 substrate-specific transmembrane transporter activity Losses GO:0030246 carbohydrate binding Losses GO:0004930 G-protein coupled receptor activity Losses GO:0016015 morphogen activity Losses GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity Losses GO:0005251 delayed rectifier potassium channel activity Losses GO:0003995 acyl-CoA dehydrogenase activity Losses GO:0015075 ion transmembrane transporter activity Losses GO:0016491 oxidoreductase activity Losses GO:0004888 transmembrane signaling receptor activity Losses GO:0005267 potassium channel activity Losses GO:0008083 growth factor activity Losses GO:0022892 substrate-specific transporter activity Losses GO:0004467 long-chain fatty acid-CoA ligase activity Losses GO:0015645 fatty acid ligase activity Losses GO:0015103 inorganic anion transmembrane transporter activity Losses GO:0004872 receptor activity Losses GO:0015079 potassium ion transmembrane transporter activity Losses GO:0003697 single-stranded DNA binding Losses GO:0099600 transmembrane receptor activity Losses GO:0008172 S-methyltransferase activity Losses GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity Losses GO:0051213 dioxygenase activity Losses GO:0008484 sulfuric ester hydrolase activity Losses GO:0008417 fucosyltransferase activity Losses GO:0008762 UDP-N-acetylmuramate dehydrogenase activity Losses GO:0005121 Toll binding Losses GO:0005249 voltage-gated potassium channel activity Losses GO:0043890 N-acetylgalactosamine-6-sulfatase activity Losses GO:0047548 2-methyleneglutarate mutase activity Losses GO:0010385 double-stranded methylated DNA binding Losses GO:0106050 tRNA 2'-O-methyltransferase activity Losses GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity Losses GO:0008459 chondroitin 6-sulfotransferase activity Losses GO:0015322 secondary active oligopeptide transmembrane transporter activity Losses GO:0042084 5-methyltetrahydrofolate-dependent methyltransferase activity Losses GO:0004334 fumarylacetoacetase activity Losses GO:0033932 1,3-alpha-L-fucosidase activity Losses GO:0004493 methylmalonyl-CoA epimerase activity Losses GO:0004494 methylmalonyl-CoA mutase activity Losses GO:0008196 vitellogenin receptor activity Losses GO:0042943 D-amino acid transmembrane transporter activity Losses GO:0004459 L-lactate dehydrogenase activity Losses GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity Losses GO:0032183 SUMO binding Losses GO:0005329 dopamine transmembrane transporter activity Losses GO:0015175 neutral amino acid transmembrane transporter activity Losses GO:0015142 tricarboxylic acid transmembrane transporter activity Losses GO:0015137 citrate transmembrane transporter activity Losses GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity Losses GO:0015222 serotonin transmembrane transporter activity Losses GO:0008705 methionine synthase activity Losses GO:0005125 cytokine activity Losses GO:0000293 ferric-chelate reductase activity Losses GO:0004773 steryl-sulfatase activity Losses GO:0019811 cocaine binding Losses GO:0008833 deoxyribonuclease IV (phage-T4-induced) activity Losses GO:0008836 diaminopimelate decarboxylase activity Losses GO:0008802 betaine-aldehyde dehydrogenase activity Losses GO:0005225 volume-sensitive anion channel activity Losses GO:0052813 phosphatidylinositol bisphosphate kinase activity Losses GO:0008579 JUN kinase phosphatase activity Losses GO:0008511 sodium:potassium:chloride symporter activity Losses GO:0047323 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity Losses GO:0047341 fucose-1-phosphate guanylyltransferase activity Losses GO:0004586 ornithine decarboxylase activity Losses GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity Losses GO:0001760 aminocarboxymuconate-semialdehyde decarboxylase activity Losses GO:0003911 DNA ligase (NAD+) activity Losses GO:0033735 aspartate dehydrogenase activity Losses GO:0072320 volume-sensitive chloride channel activity Losses GO:0047150 betaine-homocysteine S-methyltransferase activity Losses GO:0047131 saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity Losses GO:0030429 kynureninase activity Losses GO:0042806 fucose binding Losses GO:0016595 glutamate binding Losses GO:0016524 latrotoxin receptor activity Losses GO:0001642 group III metabotropic glutamate receptor activity Losses GO:0004960 thromboxane receptor activity Losses GO:0018392 glycoprotein 3-alpha-L-fucosyltransferase activity Losses GO:0004953 icosanoid receptor activity Losses GO:0004954 prostanoid receptor activity Losses GO:0004955 prostaglandin receptor activity Losses GO:0004957 prostaglandin E receptor activity Losses GO:0050291 sphingosine N-acyltransferase activity Losses GO:0009020 tRNA (guanosine-2'-O-)-methyltransferase activity Losses GO:0004936 alpha-adrenergic receptor activity Losses GO:0004937 alpha1-adrenergic receptor activity Losses GO:0015291 secondary active transmembrane transporter activity Losses GO:0060089 molecular transducer activity Losses GO:0016886 ligase activity, forming phosphoric ester bonds Losses GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters Losses GO:0004344 glucose dehydrogenase activity Novel expansions GO:0008812 choline dehydrogenase activity Novel expansions GO:0016084 myostimulatory hormone activity Novel expansions GO:0005550 pheromone binding Novel expansions GO:0008084 imaginal disc growth factor receptor binding Novel expansions GO:0005549 odorant binding Novel expansions GO:0046914 transition metal ion binding Novel expansions GO:0008447 L-ascorbate oxidase activity Novel expansions GO:0004768 stearoyl-CoA 9-desaturase activity Novel expansions GO:0016215 acyl-CoA desaturase activity Novel expansions GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor Novel expansions GO:0003964 RNA-directed DNA polymerase activity Novel expansions GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Novel expansions GO:0004930 G-protein coupled receptor activity Extinctions GO:0031419 cobalamin binding Extinctions GO:0003995 acyl-CoA dehydrogenase activity Extinctions GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity Extinctions GO:0051213 dioxygenase activity Extinctions GO:0004888 transmembrane signaling receptor activity Extinctions GO:0008172 S-methyltransferase activity Extinctions GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity Extinctions GO:0099600 transmembrane receptor activity Extinctions GO:0008484 sulfuric ester hydrolase activity Extinctions GO:0008762 UDP-N-acetylmuramate dehydrogenase activity Extinctions GO:0016491 oxidoreductase activity Extinctions GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters Extinctions GO:0038023 signaling receptor activity Extinctions GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors Extinctions GO:0043890 N-acetylgalactosamine-6-sulfatase activity Extinctions GO:0047548 2-methyleneglutarate mutase activity Extinctions GO:0106050 tRNA 2'-O-methyltransferase activity Extinctions GO:0042084 5-methyltetrahydrofolate-dependent methyltransferase activity Extinctions GO:0004493 methylmalonyl-CoA epimerase activity Extinctions GO:0004494 methylmalonyl-CoA mutase activity Extinctions GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity Extinctions GO:0032183 SUMO binding Extinctions GO:0008705 methionine synthase activity Extinctions GO:0004773 steryl-sulfatase activity Extinctions GO:0008833 deoxyribonuclease IV (phage-T4-induced) activity Extinctions GO:0008802 betaine-aldehyde dehydrogenase activity Extinctions GO:0047323 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity Extinctions GO:0047341 fucose-1-phosphate guanylyltransferase activity Extinctions GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity Extinctions GO:0001760 aminocarboxymuconate-semialdehyde decarboxylase activity Extinctions GO:0033735 aspartate dehydrogenase activity Extinctions GO:0047150 betaine-homocysteine S-methyltransferase activity Extinctions GO:0030429 kynureninase activity Extinctions GO:0016595 glutamate binding Extinctions GO:0001642 group III metabotropic glutamate receptor activity Extinctions GO:0004960 thromboxane receptor activity Extinctions GO:0004953 icosanoid receptor activity Extinctions GO:0004954 prostanoid receptor activity Extinctions GO:0004955 prostaglandin receptor activity Extinctions GO:0004957 prostaglandin E receptor activity Extinctions GO:0009020 tRNA (guanosine-2'-O-)-methyltransferase activity Extinctions GO:0004936 alpha-adrenergic receptor activity Extinctions GO:0004937 alpha1-adrenergic receptor activity Extinctions GO:0050660 flavin adenine dinucleotide binding Extinctions GO:0008175 tRNA methyltransferase activity Extinctions GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Extinctions GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Extinctions GO:0098988 G-protein coupled glutamate receptor activity Extinctions GO:0008445 D-aspartate oxidase activity Extinctions GO:0004458 D-lactate dehydrogenase (cytochrome) activity Extinctions GO:0015459 potassium channel regulator activity Extinctions GO:0015485 cholesterol binding Extinctions GO:0030696 tRNA (m5U54) methyltransferase activity Extinctions GO:0030697 S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity Extinctions GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity Extinctions GO:0003884 D-amino-acid oxidase activity Extinctions GO:0016300 tRNA (uracil) methyltransferase activity Extinctions GO:0016208 AMP binding Extinctions GO:0016898 oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor Extinctions GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds Extinctions GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances Extinctions GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity Extinctions GO:0001641 group II metabotropic glutamate receptor activity Extinctions GO:0015922 aspartate oxidase activity Extinctions GO:0004872 receptor activity Extinctions GO:0019842 vitamin binding Extinctions