Domain arrangement Fusions Fissions Terminal losses Terminal emergences Single domain losses Single domain emergences PF00004 0 1 0 0 0 0 PF00008 PF00431 1 0 0 0 0 0 PF00008 PF02210 1 0 0 0 0 0 PF00008 PF12661 0 1 0 0 0 0 PF00008 PF12661 PF00008 0 1 0 0 0 0 PF00010 0 1 0 0 0 0 PF00010 PF00989 1 0 0 0 0 0 PF00013 PF00270 PF00271 1 0 0 0 0 0 PF00018 PF00017 1 0 0 0 0 0 PF00041 PF07679 1 0 0 0 0 0 PF00041 PF07679 PF00041 1 0 0 0 0 0 PF00046 0 3 0 0 0 0 PF00057 PF00629 1 0 0 0 0 0 PF00071 PF00651 1 0 0 0 0 0 PF00076 0 1 0 0 0 0 PF00078 PF05380 1 0 0 0 0 0 PF00088 0 0 3 0 0 0 PF00089 PF00057 1 0 0 0 0 0 PF00090 0 1 0 0 0 0 PF00092 0 1 0 0 0 0 PF00092 PF07699 PF00084 1 0 0 0 0 0 PF00096 PF13912 PF13894 1 0 0 0 0 0 PF00108 0 1 0 0 0 0 PF00109 0 1 0 0 0 0 PF00157 0 1 0 0 0 0 PF00168 0 2 0 0 0 0 PF00246 0 1 0 0 0 0 PF00355 PF07992 1 0 0 0 0 0 PF00413 PF00045 1 0 0 0 0 0 PF00551 0 1 0 0 0 0 PF00560 0 1 0 0 0 0 PF00562 PF04560 0 0 4 0 0 0 PF00595 PF00063 1 0 0 0 0 0 PF00595 PF00536 1 0 0 0 0 0 PF00595 PF00640 1 0 0 0 0 0 PF00610 0 1 0 0 0 0 PF00650 0 1 0 0 0 0 PF00781 PF00609 1 0 0 0 0 0 PF00782 0 1 0 0 0 0 PF00850 PF02148 1 0 0 0 0 0 PF00852 0 1 0 0 0 0 PF00890 0 0 1 0 0 0 PF01042 0 0 0 0 1 0 PF01391 0 2 0 0 0 0 PF01410 0 1 0 0 0 0 PF01414 PF00008 0 1 0 0 0 0 PF01434 0 1 0 0 0 0 PF01462 0 1 0 0 0 0 PF01498 PF13358 1 0 0 0 0 0 PF01586 0 1 0 0 0 0 PF01825 PF01477 1 0 0 0 0 0 PF01834 0 0 2 0 0 0 PF02037 PF00076 1 0 0 0 0 0 PF02210 PF01034 1 0 0 0 0 0 PF02238 0 0 0 0 1 0 PF02244 0 1 0 0 0 0 PF02494 PF07699 1 0 0 0 0 0 PF02709 0 0 1 0 0 0 PF02798 PF00043 1 0 0 0 0 0 PF02801 0 1 0 0 0 0 PF02803 0 1 0 0 0 0 PF02898 PF00258 1 0 0 0 0 0 PF02911 0 1 0 0 0 0 PF03007 0 0 1 0 0 0 PF03160 PF01826 1 0 0 0 0 0 PF03351 PF01082 0 1 0 0 0 0 PF03441 0 0 1 0 0 0 PF03473 0 0 1 0 0 0 PF03485 PF00750 0 1 0 0 0 0 PF03493 0 1 0 0 0 0 PF03547 0 1 0 0 0 0 PF03712 0 1 0 0 0 0 PF03721 0 0 2 0 0 0 PF03723 0 0 3 0 0 0 PF03765 0 1 0 0 0 0 PF04627 0 0 0 0 1 0 PF04734 0 0 1 0 0 0 PF04960 0 1 0 0 0 0 PF05724 0 0 0 0 1 0 PF05746 0 1 0 0 0 0 PF05773 PF01485 1 0 0 0 0 0 PF06331 0 0 0 0 1 0 PF06396 0 0 0 0 1 0 PF06468 0 1 0 0 0 0 PF06482 0 1 0 0 0 0 PF06677 0 0 0 0 1 0 PF06682 0 0 0 0 1 0 PF07524 0 1 0 0 0 0 PF07647 PF00536 1 0 0 0 0 0 PF07657 0 1 0 0 0 0 PF07662 0 0 2 0 0 0 PF07677 0 1 0 0 0 0 PF07699 0 1 0 0 0 0 PF07700 0 1 0 0 0 0 PF07701 PF00211 0 1 0 0 0 0 PF07724 0 1 0 0 0 0 PF07815 0 1 0 0 0 0 PF07885 0 1 0 0 0 0 PF07995 0 0 0 0 1 0 PF08022 PF08030 0 0 5 0 0 0 PF08208 0 0 0 0 1 0 PF08240 0 1 0 0 0 0 PF08311 PF00069 1 0 0 0 0 0 PF08506 PF03378 1 0 0 0 0 0 PF08699 PF02170 PF02171 1 0 1 0 0 0 PF09334 PF00458 1 0 0 0 0 0 PF09779 0 0 0 0 1 0 PF10272 0 0 0 0 1 0 PF10394 PF00583 1 0 0 0 0 0 PF10406 0 1 0 0 0 0 PF10431 0 1 0 0 0 0 PF10508 0 0 0 0 1 0 PF10540 0 1 0 0 0 0 PF10569 PF07678 0 1 0 0 0 0 PF10914 0 0 0 0 1 0 PF11987 0 0 2 0 0 0 PF12353 0 1 0 0 0 0 PF12407 0 1 0 0 0 0 PF12460 0 0 0 0 1 0 PF12767 0 0 0 0 1 0 PF12796 0 1 0 0 0 0 PF12796 PF13606 PF12796 1 0 0 0 0 0 PF12799 PF13855 1 0 0 0 0 0 PF12874 PF00096 PF12874 PF00096 PF13912 1 0 0 0 0 0 PF12874 PF00096 PF12874 PF13894 PF00096 1 0 0 0 0 0 PF12874 PF12171 1 0 0 0 0 0 PF12874 PF13894 PF13912 1 0 0 0 0 0 PF12874 PF13912 PF00096 PF12874 1 0 0 0 0 0 PF13181 PF07719 1 0 0 0 0 0 PF13229 PF02207 1 0 0 0 0 0 PF13279 0 0 0 0 1 0 PF13365 0 0 1 0 0 0 PF13384 PF01498 1 0 0 0 0 0 PF13401 0 0 1 0 0 0 PF13405 PF00036 1 0 0 0 0 0 PF13602 0 1 0 0 0 0 PF13637 PF12796 PF00023 1 0 0 0 0 0 PF13815 0 0 0 0 1 0 PF13855 0 2 0 0 0 0 PF13855 PF13516 PF13855 1 0 0 0 0 0 PF13894 PF12874 PF00096 PF12874 1 0 0 0 0 0 PF13895 PF13927 1 0 0 0 0 0 PF13909 PF00096 1 0 0 0 0 0 PF14604 0 1 0 0 0 0 PF14604 PF00018 1 0 0 0 0 0 PF14634 PF00642 1 0 0 0 0 0 PF14671 0 1 0 0 0 0 PF14939 0 0 0 0 1 0 PF14966 0 0 0 0 1 0 PF15497 0 0 0 0 1 0 PF15914 0 0 0 0 1 0 PF16165 0 1 0 0 0 0 PF16763 0 0 0 0 0 1 PF16878 0 1 0 0 0 0 PF17039 0 1 0 0 0 0