GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0008417	fucosyltransferase activity	Gains
GO:0003676	nucleic acid binding	Gains
GO:0004872	receptor activity	Gains
GO:0004518	nuclease activity	Gains
GO:0004519	endonuclease activity	Gains
GO:0004803	transposase activity	Gains
GO:0015276	ligand-gated ion channel activity	Gains
GO:0022834	ligand-gated channel activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Gains
GO:0016151	nickel cation binding	Gains
GO:0038023	signaling receptor activity	Gains
GO:0005230	extracellular ligand-gated ion channel activity	Gains
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0016788	hydrolase activity, acting on ester bonds	Gains
GO:0004713	protein tyrosine kinase activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0005310	dicarboxylic acid transmembrane transporter activity	Gains
GO:0003677	DNA binding	Gains
GO:0004175	endopeptidase activity	Gains
GO:0004521	endoribonuclease activity	Gains
GO:0005088	Ras guanyl-nucleotide exchange factor activity	Gains
GO:0008083	growth factor activity	Gains
GO:0004252	serine-type endopeptidase activity	Gains
GO:0004867	serine-type endopeptidase inhibitor activity	Gains
GO:0004383	guanylate cyclase activity	Gains
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
GO:0097747	RNA polymerase activity	Gains
GO:0034062	5'-3' RNA polymerase activity	Gains
GO:0015267	channel activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0003777	microtubule motor activity	Gains
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Gains
GO:0005216	ion channel activity	Gains
GO:0004866	endopeptidase inhibitor activity	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0022836	gated channel activity	Gains
GO:0030414	peptidase inhibitor activity	Gains
GO:0016740	transferase activity	Gains
GO:0016917	GABA receptor activity	Gains
GO:0004736	pyruvate carboxylase activity	Gains
GO:0015928	fucosidase activity	Gains
GO:0004890	GABA-A receptor activity	Gains
GO:0004560	alpha-L-fucosidase activity	Gains
GO:0003939	L-iditol 2-dehydrogenase activity	Gains
GO:0036122	BMP binding	Gains
GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Gains
GO:0032135	DNA insertion or deletion binding	Gains
GO:0032137	guanine/thymine mispair binding	Gains
GO:0032138	single base insertion or deletion binding	Gains
GO:0005314	high-affinity glutamate transmembrane transporter activity	Gains
GO:0046920	alpha-(1->3)-fucosyltransferase activity	Gains
GO:0004372	glycine hydroxymethyltransferase activity	Gains
GO:0035197	siRNA binding	Gains
GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	Gains
GO:0019199	transmembrane receptor protein kinase activity	Gains
GO:0016849	phosphorus-oxygen lyase activity	Gains
GO:0017048	Rho GTPase binding	Gains
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
GO:0015172	acidic amino acid transmembrane transporter activity	Gains
GO:0004075	biotin carboxylase activity	Gains
GO:0019825	oxygen binding	Gains
GO:0005313	L-glutamate transmembrane transporter activity	Gains
GO:0019955	cytokine binding	Gains
GO:0061135	endopeptidase regulator activity	Gains
GO:0035251	UDP-glucosyltransferase activity	Gains
GO:0008233	peptidase activity	Gains
GO:0097159	organic cyclic compound binding	Gains
GO:0009975	cyclase activity	Gains
GO:1901363	heterocyclic compound binding	Gains
GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Gains
GO:0005342	organic acid transmembrane transporter activity	Gains
GO:0046943	carboxylic acid transmembrane transporter activity	Gains
GO:0017171	serine hydrolase activity	Gains
GO:0008527	taste receptor activity	Losses
GO:0031409	pigment binding	Losses
GO:0046914	transition metal ion binding	Losses
GO:0008395	steroid hydroxylase activity	Losses
GO:0070330	aromatase activity	Losses
GO:0140104	molecular carrier activity	Losses
GO:0005381	iron ion transmembrane transporter activity	Losses
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
GO:0052745	inositol phosphate phosphatase activity	Losses
GO:0005215	transporter activity	Losses
GO:0042302	structural constituent of cuticle	Losses
GO:0031177	phosphopantetheine binding	Losses
GO:0044620	ACP phosphopantetheine attachment site binding	Losses
GO:0004508	steroid 17-alpha-monooxygenase activity	Losses
GO:0019113	limonene monooxygenase activity	Losses
GO:0008031	eclosion hormone activity	Losses
GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Losses
GO:0035650	AP-1 adaptor complex binding	Losses
GO:0034584	piRNA binding	Losses
GO:0004099	chitin deacetylase activity	Losses
GO:0072320	volume-sensitive chloride channel activity	Losses
GO:0000036	acyl carrier activity	Losses
GO:0018676	(S)-limonene 7-monooxygenase activity	Losses
GO:0051192	prosthetic group binding	Losses
GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Losses
GO:0004446	inositol-hexakisphosphate phosphatase activity	Losses
GO:0035302	ecdysteroid 25-hydroxylase activity	Losses
GO:0003839	gamma-glutamylcyclotransferase activity	Losses
GO:0005225	volume-sensitive anion channel activity	Losses
GO:0008511	sodium:potassium:chloride symporter activity	Losses
GO:0022853	active ion transmembrane transporter activity	Losses
GO:0015108	chloride transmembrane transporter activity	Losses
GO:0008270	zinc ion binding	Losses
GO:0005507	copper ion binding	Losses
GO:0046915	transition metal ion transmembrane transporter activity	Losses
GO:0005214	structural constituent of chitin-based cuticle	Losses
GO:0008061	chitin binding	Losses
GO:0022857	transmembrane transporter activity	Losses
GO:0022892	substrate-specific transporter activity	Losses
GO:0004497	monooxygenase activity	Losses
GO:0022891	substrate-specific transmembrane transporter activity	Losses
GO:0016531	copper chaperone activity	Losses
GO:0015377	cation:chloride symporter activity	Losses
GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
GO:0008934	inositol monophosphate 1-phosphatase activity	Losses
GO:0015417	polyamine-transporting ATPase activity	Losses
GO:0052832	inositol monophosphate 3-phosphatase activity	Losses
GO:0052833	inositol monophosphate 4-phosphatase activity	Losses
GO:0052834	inositol monophosphate phosphatase activity	Losses
GO:0015203	polyamine transmembrane transporter activity	Losses
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	Losses
GO:0008113	peptide-methionine (S)-S-oxide reductase activity	Losses
GO:0008260	3-oxoacid CoA-transferase activity	Losses
GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	Losses
GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Losses
GO:0033743	peptide-methionine (R)-S-oxide reductase activity	Losses
GO:0005272	sodium channel activity	Losses
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
GO:0016849	phosphorus-oxygen lyase activity	Losses
GO:0043492	ATPase activity, coupled to movement of substances	Losses
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Losses
GO:0015075	ion transmembrane transporter activity	Losses
GO:0097747	RNA polymerase activity	Losses
GO:0034062	5'-3' RNA polymerase activity	Losses
GO:0016491	oxidoreductase activity	Losses
GO:0015399	primary active transmembrane transporter activity	Losses
GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	Losses
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	Losses
GO:0009975	cyclase activity	Losses
GO:0018454	acetoacetyl-CoA reductase activity	Losses
GO:0004504	peptidylglycine monooxygenase activity	Losses
GO:0009922	fatty acid elongase activity	Losses
GO:0004090	carbonyl reductase (NADPH) activity	Losses
GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	Losses
GO:0008410	CoA-transferase activity	Losses
GO:0004344	glucose dehydrogenase activity	Losses
GO:0050321	tau-protein kinase activity	Losses
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Losses
GO:0008812	choline dehydrogenase activity	Losses
GO:0050333	thiamin-triphosphatase activity	Novel expansions
GO:0005230	extracellular ligand-gated ion channel activity	Novel expansions
GO:0004713	protein tyrosine kinase activity	Novel expansions
GO:0015276	ligand-gated ion channel activity	Novel expansions
GO:0022834	ligand-gated channel activity	Novel expansions
GO:0016151	nickel cation binding	Novel expansions
GO:0099600	transmembrane receptor activity	Novel expansions
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Novel expansions
GO:0022836	gated channel activity	Novel expansions
GO:0004872	receptor activity	Novel expansions
GO:0060089	molecular transducer activity	Novel expansions
GO:0140104	molecular carrier activity	Extinctions
GO:0031177	phosphopantetheine binding	Extinctions
GO:0044620	ACP phosphopantetheine attachment site binding	Extinctions
GO:0035650	AP-1 adaptor complex binding	Extinctions
GO:0000036	acyl carrier activity	Extinctions
GO:0051192	prosthetic group binding	Extinctions
GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Extinctions
GO:0035302	ecdysteroid 25-hydroxylase activity	Extinctions
GO:0003839	gamma-glutamylcyclotransferase activity	Extinctions
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Extinctions
GO:0097747	RNA polymerase activity	Extinctions
GO:0034062	5'-3' RNA polymerase activity	Extinctions
GO:0016531	copper chaperone activity	Extinctions
GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Extinctions
GO:0004090	carbonyl reductase (NADPH) activity	Extinctions
GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	Extinctions
GO:0050321	tau-protein kinase activity	Extinctions
GO:0004697	protein kinase C activity	Extinctions
GO:0042302	structural constituent of cuticle	Extinctions
GO:0016530	metallochaperone activity	Extinctions
GO:0031625	ubiquitin protein ligase binding	Extinctions
GO:0044389	ubiquitin-like protein ligase binding	Extinctions
GO:0004012	phospholipid-translocating ATPase activity	Extinctions
GO:0008527	taste receptor activity	Extinctions