Domain arrangement Fusions Fissions Terminal losses Terminal emergences Single domain losses Single domain emergences PF00003 PF00147 1 0 0 0 0 0 PF00005 PF01061 PF00005 PF01061 1 0 0 0 0 0 PF00005 PF01061 PF01161 1 0 0 0 0 0 PF00008 PF01049 0 0 5 0 0 0 PF00009 PF03144 PF01728 PF11861 PF07780 1 0 0 0 0 0 PF00009 PF14492 PF00679 PF02671 PF08295 PF16879 1 0 0 0 0 0 PF00012 PF01997 1 0 0 0 0 0 PF00018 PF00621 1 0 0 0 0 0 PF00023 PF00520 1 0 0 0 0 0 PF00023 PF12796 PF00483 PF00132 1 0 0 0 0 0 PF00023 PF12796 PF00651 1 0 0 0 0 0 PF00023 PF12796 PF07714 1 0 0 0 0 0 PF00024 PF01607 1 0 0 0 0 0 PF00025 PF13967 PF14703 PF02714 1 0 0 0 0 0 PF00047 PF13927 1 0 0 0 0 0 PF00060 PF13639 1 0 0 0 0 0 PF00061 PF08212 1 0 0 0 0 0 PF00067 PF07776 1 0 0 0 0 0 PF00069 PF00433 PF03148 1 0 0 0 0 0 PF00071 PF00017 1 0 0 0 0 0 PF00071 PF00076 1 0 0 0 0 0 PF00071 PF01412 PF00501 PF13193 1 0 0 0 0 0 PF00076 0 2 0 0 0 0 PF00076 PF00722 1 0 0 0 0 0 PF00076 PF08240 PF13602 1 0 0 0 0 0 PF00076 PF12937 1 0 0 0 0 0 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1 0 0 0 0 0 PF00179 PF00400 1 0 0 0 0 0 PF00183 PF00328 1 0 0 0 0 0 PF00188 PF04193 1 0 0 0 0 0 PF00206 PF14698 PF03055 1 0 0 0 0 0 PF00207 0 0 4 0 0 0 PF00209 PF12937 PF00179 1 0 0 0 0 0 PF00225 0 1 0 0 0 0 PF00225 PF01392 PF00051 PF07714 1 0 0 0 0 0 PF00249 PF13921 PF09316 PF08159 1 0 0 0 0 0 PF00254 PF13181 PF00515 1 0 0 0 0 0 PF00254 PF13432 1 0 0 0 0 0 PF00258 PF00667 PF00175 PF13920 1 0 0 0 0 0 PF00270 PF00271 PF00179 1 0 0 0 0 0 PF00270 PF00271 PF00719 1 0 0 0 0 0 PF00270 PF00271 PF02463 1 0 0 0 0 0 PF00271 PF04408 PF07717 0 1 0 0 0 0 PF00282 PF16213 PF12783 PF01369 PF09324 1 0 0 0 0 0 PF00327 PF00118 1 0 0 0 0 0 PF00335 PF00790 PF01363 PF12210 1 0 0 0 0 0 PF00338 PF07528 1 0 0 0 0 0 PF00338 PF13251 1 0 0 0 0 0 PF00339 PF02752 PF00012 1 0 0 0 0 0 PF00348 PF13344 PF13242 1 0 0 0 0 0 PF00370 PF02782 PF00002 1 0 0 0 0 0 PF00378 PF09445 1 0 0 0 0 0 PF00385 PF00176 PF00271 1 0 1 0 0 0 PF00385 PF01393 PF05470 PF01399 1 0 0 0 0 0 PF00400 0 1 0 0 0 0 PF00400 PF00069 1 0 0 0 0 0 PF00400 PF00892 1 0 0 0 0 0 PF00400 PF02359 PF02933 PF00004 PF09336 1 0 0 0 0 0 PF00400 PF03343 1 0 0 0 0 0 PF00400 PF10345 1 0 0 0 0 0 PF00400 PF13833 1 0 0 0 0 0 PF00415 0 1 0 0 0 0 PF00415 PF13540 0 1 0 0 0 0 PF00431 PF00089 PF00431 PF00089 1 0 0 0 0 0 PF00436 PF05427 1 0 0 0 0 0 PF00443 PF01553 1 0 0 0 0 0 PF00468 0 0 0 0 1 0 PF00481 PF00651 PF07707 1 0 0 0 0 0 PF00484 0 0 0 0 1 0 PF00498 PF00250 PF10259 1 0 0 0 0 0 PF00505 PF00651 PF07707 PF01344 1 0 0 0 0 0 PF00535 PF00652 PF00400 1 0 0 0 0 0 PF00536 PF02221 1 0 0 0 0 0 PF00536 PF07647 PF13676 1 0 0 0 0 0 PF00549 0 1 1 0 0 0 PF00557 PF05018 1 0 0 0 0 0 PF00561 PF07841 1 0 0 0 0 0 PF00561 PF11176 1 0 0 0 0 0 PF00569 0 0 6 0 0 0 PF00618 PF00595 PF00788 PF00617 PF01030 PF00757 PF01030 1 0 0 0 0 0 PF00620 PF00067 1 0 0 0 0 0 PF00621 PF00169 1 0 0 0 0 0 PF00621 PF00620 1 0 0 0 0 0 PF00628 PF01565 PF02913 1 0 0 0 0 0 PF00628 PF01853 1 0 0 0 0 0 PF00640 PF01070 1 0 0 0 0 0 PF00643 PF00630 1 0 0 0 0 0 PF00646 PF12248 1 0 0 0 0 0 PF00648 PF01067 PF00732 PF05199 PF00732 PF05199 1 0 0 0 0 0 PF00653 PF13920 PF00653 PF13920 1 0 0 0 0 0 PF00658 0 1 0 0 0 0 PF00664 PF00005 PF00664 PF00005 PF00664 PF00005 1 0 0 0 0 0 PF00667 PF00175 PF00667 PF00175 1 0 0 0 0 0 PF00692 0 0 0 0 1 0 PF00704 PF07690 1 0 0 0 0 0 PF00732 PF05199 PF00732 PF05199 PF00732 PF05199 PF00732 PF05199 PF00732 PF05199 1 0 0 0 0 0 PF00784 PF00620 PF02348 1 0 0 0 0 0 PF00790 PF03127 PF01144 1 0 0 0 0 0 PF00817 PF11799 PF00400 1 0 0 0 0 0 PF00856 PF01105 1 0 0 0 0 0 PF00858 PF02636 1 0 0 0 0 0 PF00887 PF13857 1 0 0 0 0 0 PF00916 PF01740 PF00153 1 0 0 0 0 0 PF00916 PF01740 PF00916 PF01740 1 0 0 0 0 0 PF00916 PF01740 PF07776 1 0 0 0 0 0 PF01014 PF00431 1 0 0 0 0 0 PF01019 PF02046 1 0 0 0 0 0 PF01027 PF06825 1 0 0 0 0 0 PF01064 PF08515 PF00069 PF05063 1 0 0 0 0 0 PF01066 PF08445 1 0 0 0 0 0 PF01074 PF09261 PF07748 PF01074 PF09261 PF07748 1 0 0 0 0 0 PF01074 PF09261 PF07748 PF03416 1 0 0 0 0 0 PF01091 PF10433 PF03178 1 0 0 0 0 0 PF01094 0 1 0 0 0 0 PF01094 PF10613 PF00060 PF01094 PF10613 PF00060 1 0 0 0 0 0 PF01121 PF02469 1 0 0 0 0 0 PF01200 PF00076 1 0 0 0 0 0 PF01250 0 0 0 0 1 0 PF01299 PF09728 1 0 0 0 0 0 PF01302 PF00443 1 0 0 0 0 0 PF01336 PF00152 PF03360 1 0 0 0 0 0 PF01347 PF02244 PF00246 PF02244 PF00246 PF02244 PF00246 1 0 0 0 0 0 PF01391 PF01410 PF00675 PF05193 1 0 0 0 0 0 PF01391 PF01413 PF01529 1 0 0 0 0 0 PF01392 PF00057 PF00089 1 0 0 0 0 0 PF01395 PF00135 1 0 0 0 0 0 PF01398 PF02970 1 0 0 0 0 0 PF01398 PF13012 PF00383 1 0 0 0 0 0 PF01423 PF00004 1 0 0 0 0 0 PF01423 PF05761 1 0 0 0 0 0 PF01428 PF02809 PF05091 1 0 0 0 0 0 PF01433 PF11838 PF00089 1 0 0 0 0 0 PF01433 PF11838 PF01433 PF11838 PF01433 PF11838 PF00089 1 0 0 0 0 0 PF01467 PF00089 1 0 0 0 0 0 PF01581 0 0 0 0 1 0 PF01585 0 1 0 0 0 0 PF01612 PF08243 1 0 0 0 0 0 PF01633 PF02770 PF01756 1 0 0 0 0 0 PF01699 PF03820 1 0 0 0 0 0 PF01757 PF00246 1 0 0 0 0 0 PF01779 0 0 0 0 1 0 PF01794 PF08022 PF08030 PF06728 1 0 0 0 0 0 PF01822 PF00041 PF07714 PF13359 1 0 0 0 0 0 PF01826 PF01217 1 0 0 0 0 0 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PF17207 PF00493 1 0 0 0 0 0 PF03159 PF11571 1 0 0 0 0 0 PF03165 0 1 0 0 0 0 PF03171 PF04627 1 0 0 0 0 0 PF03301 PF08246 PF00112 1 0 0 0 0 0 PF03360 PF01347 PF09172 PF06448 PF00094 1 0 0 0 0 0 PF03399 PF14959 1 0 0 0 0 0 PF03446 PF00393 PF05347 1 0 0 0 0 0 PF03456 PF02141 PF03455 PF02759 PF01477 PF02759 PF13522 PF01380 1 0 0 0 0 0 PF03637 PF10408 PF04564 1 0 0 0 0 0 PF03656 PF15052 1 0 0 0 0 0 PF03657 0 0 0 0 1 0 PF03660 0 0 0 0 1 0 PF03715 PF13489 1 0 0 0 0 0 PF03722 PF00372 PF03723 PF03722 PF00372 PF03723 1 0 0 0 0 0 PF03810 0 1 0 0 0 0 PF03820 PF00102 1 0 0 0 0 0 PF03879 0 0 0 0 1 0 PF03920 0 1 0 0 0 0 PF04000 0 1 0 0 0 0 PF04129 PF00009 PF03144 PF14492 PF03764 PF00679 1 0 0 0 0 0 PF04495 PF10183 1 0 0 0 0 0 PF04515 PF00916 PF01740 1 0 0 0 0 0 PF04597 0 0 0 0 1 0 PF04675 PF01068 PF04679 PF14655 PF14656 1 0 0 0 0 0 PF04677 PF04676 PF04099 1 0 0 0 0 0 PF04889 PF00076 1 0 0 0 0 0 PF04906 PF05291 1 0 0 0 0 0 PF04928 PF04926 PF09752 1 0 0 0 0 0 PF04931 PF00004 1 0 0 0 0 0 PF04939 PF07847 1 0 0 0 0 0 PF04997 PF00623 PF04983 PF05000 PF04998 PF08073 PF00628 PF00385 PF00176 PF00271 PF06465 PF06461 PF08074 1 0 0 0 0 0 PF05024 PF05154 1 0 0 0 0 0 PF05030 0 0 0 0 1 0 PF05180 PF00557 1 0 0 0 0 0 PF05208 PF03184 1 0 0 0 0 0 PF05225 PF05571 1 0 0 0 0 0 PF05253 PF10200 1 0 0 0 0 0 PF05303 0 0 0 0 1 0 PF05405 PF08395 1 0 0 0 0 0 PF05444 PF09751 1 0 0 0 0 0 PF05485 PF00096 PF13894 1 0 0 0 0 0 PF05485 PF00213 1 0 0 0 0 0 PF05510 PF12894 PF00400 PF04003 1 0 0 0 0 0 PF05620 PF15359 1 0 0 0 0 0 PF05648 PF13637 1 0 0 0 0 0 PF05705 PF04821 PF05029 1 0 0 0 0 0 PF05741 0 0 0 0 1 0 PF05811 PF00106 1 0 0 0 0 0 PF05916 PF13815 1 0 0 0 0 0 PF05971 0 0 0 0 1 0 PF06003 PF09748 1 0 0 0 0 0 PF06325 PF00179 1 0 0 0 0 0 PF06544 0 0 1 0 0 0 PF06743 PF00557 1 0 0 0 0 0 PF06747 PF00651 1 0 0 0 0 0 PF06747 PF02441 1 0 0 0 0 0 PF06842 PF02338 1 0 0 0 0 0 PF06862 PF07776 1 0 0 0 0 0 PF07114 PF03670 1 0 0 0 0 0 PF07177 PF13912 1 0 0 0 0 0 PF07412 0 0 0 0 1 0 PF07534 PF01379 PF03900 1 0 0 0 0 0 PF07572 0 0 0 0 1 0 PF07647 PF00536 1 0 0 0 0 0 PF07653 0 1 0 0 0 0 PF07679 PF13927 PF00249 1 0 0 0 0 0 PF07686 PF07679 PF13927 PF00041 PF06859 1 0 0 0 0 0 PF07690 PF00209 1 0 0 0 0 0 PF07690 PF13347 1 0 0 0 0 0 PF07703 PF00207 0 0 1 0 0 0 PF07703 PF00207 PF10569 PF07678 PF07677 0 0 1 0 0 0 PF07714 PF01412 1 0 0 0 0 0 PF07714 PF07701 PF00211 0 1 0 0 0 0 PF07776 PF00270 PF00271 PF08147 1 0 0 0 0 0 PF07776 PF00909 1 0 0 0 0 0 PF07776 PF03367 1 0 0 0 0 0 PF07776 PF13894 PF07776 1 0 0 0 0 0 PF07776 PF13912 PF07776 PF13894 PF00096 1 0 0 0 0 0 PF07776 PF13912 PF12874 PF00096 PF12874 1 0 0 0 0 0 PF07776 PF13912 PF12874 PF07776 PF13912 1 0 0 0 0 0 PF07942 PF10155 1 0 0 0 0 0 PF07974 PF07645 1 0 0 0 0 0 PF07985 0 0 0 0 1 0 PF07993 PF03015 PF00515 1 0 0 0 0 0 PF07993 PF03015 PF07993 PF03015 1 0 0 0 0 0 PF07993 PF03015 PF08395 1 0 0 0 0 0 PF08007 PF16013 1 0 0 0 0 0 PF08040 0 0 0 0 1 0 PF08064 PF02259 PF00454 PF02260 PF00675 PF05193 PF16187 PF05193 1 0 0 0 0 0 PF08154 PF00400 PF00179 1 0 0 0 0 0 PF08174 0 1 0 0 0 0 PF08205 PF13927 PF07679 1 0 0 0 0 0 PF08240 PF00107 PF16064 1 0 0 0 0 0 PF08240 PF13602 PF00082 PF12580 PF12583 1 0 0 0 0 0 PF08315 0 0 0 0 1 0 PF08336 PF13640 PF08336 PF13640 1 0 0 0 0 0 PF08389 0 1 0 0 0 0 PF08442 0 1 0 0 0 0 PF08534 PF02301 1 0 0 0 0 0 PF08551 PF00385 PF01393 1 0 0 0 0 0 PF08565 PF08564 0 0 1 0 0 0 PF08585 0 0 3 0 0 0 PF08597 0 0 0 0 1 0 PF08660 0 0 0 0 1 0 PF08696 PF13086 PF13087 PF04117 1 0 0 0 0 0 PF08743 0 0 0 0 1 0 PF08766 PF00013 PF09005 1 0 0 0 0 0 PF08784 PF00755 1 0 0 0 0 0 PF09169 PF09103 PF09104 0 0 1 0 0 0 PF09349 PF07690 1 0 0 0 0 0 PF09368 0 1 0 0 0 0 PF09416 PF13086 PF13087 PF03828 1 0 0 0 0 0 PF09457 PF00089 1 0 0 0 0 0 PF09468 PF01248 1 0 0 0 0 0 PF09507 0 0 0 0 1 0 PF09744 0 0 1 0 0 0 PF09768 PF08393 PF12774 PF12775 PF12780 PF12777 PF12781 PF03028 1 0 0 0 0 0 PF09812 PF00134 1 0 0 0 0 0 PF10058 PF17034 1 0 0 0 0 0 PF10154 PF07776 PF04500 1 0 0 0 0 0 PF10172 0 0 0 0 1 0 PF10175 0 0 0 0 1 0 PF10206 0 0 0 0 1 0 PF10218 0 0 0 0 1 0 PF10240 0 0 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