GO:0004872 receptor activity Gains GO:0060089 molecular transducer activity Gains GO:0099600 transmembrane receptor activity Gains GO:0015464 acetylcholine receptor activity Gains GO:0099528 G-protein coupled neurotransmitter receptor activity Gains GO:0016907 G-protein coupled acetylcholine receptor activity Gains GO:0003964 RNA-directed DNA polymerase activity Gains GO:0038023 signaling receptor activity Gains GO:0004871 signal transducer activity Gains GO:0008227 G-protein coupled amine receptor activity Gains GO:0004888 transmembrane signaling receptor activity Gains GO:0003796 lysozyme activity Gains GO:0003700 DNA binding transcription factor activity Gains GO:0004523 RNA-DNA hybrid ribonuclease activity Gains GO:0140110 transcription regulator activity Gains GO:0004143 diacylglycerol kinase activity Gains GO:0034061 DNA polymerase activity Gains GO:0003951 NAD+ kinase activity Gains GO:0140103 catalytic activity, acting on a glycoprotein Gains GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity Gains GO:0008836 diaminopimelate decarboxylase activity Gains GO:0071837 HMG box domain binding Gains GO:0001106 RNA polymerase II transcription corepressor activity Gains GO:0004791 thioredoxin-disulfide reductase activity Gains GO:0004586 ornithine decarboxylase activity Gains GO:0001587 Gq/11-coupled serotonin receptor activity Gains GO:0003945 N-acetyllactosamine synthase activity Gains GO:0060072 large conductance calcium-activated potassium channel activity Gains GO:0071906 CRD domain binding Gains GO:0017151 DEAD/H-box RNA helicase binding Gains GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity Gains GO:0046976 histone methyltransferase activity (H3-K27 specific) Gains GO:0004362 glutathione-disulfide reductase activity Gains GO:0004930 G-protein coupled receptor activity Gains GO:0061783 peptidoglycan muralytic activity Gains GO:0008233 peptidase activity Gains GO:0008568 microtubule-severing ATPase activity Gains GO:0008890 glycine C-acetyltransferase activity Gains GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity Gains GO:0017034 Rap guanyl-nucleotide exchange factor activity Gains GO:0004555 alpha,alpha-trehalase activity Gains GO:0004666 prostaglandin-endoperoxide synthase activity Gains GO:0015037 peptide disulfide oxidoreductase activity Gains GO:0015038 glutathione disulfide oxidoreductase activity Gains GO:0008455 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity Gains GO:0015927 trehalase activity Gains GO:0030594 neurotransmitter receptor activity Gains GO:0005200 structural constituent of cytoskeleton Losses GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Losses GO:0042834 peptidoglycan binding Losses GO:0046914 transition metal ion binding Losses GO:0008270 zinc ion binding Losses GO:0008173 RNA methyltransferase activity Losses GO:0001530 lipopolysaccharide binding Losses GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor Losses GO:0008527 taste receptor activity Losses GO:0008757 S-adenosylmethionine-dependent methyltransferase activity Losses GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors Losses GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Losses GO:0004364 glutathione transferase activity Losses GO:0005198 structural molecule activity Losses GO:0050591 quinine 3-monooxygenase activity Losses GO:0008889 glycerophosphodiester phosphodiesterase activity Losses GO:0018685 alkane 1-monooxygenase activity Losses GO:0016848 carbon-halide lyase activity Losses GO:0033777 lithocholate 6beta-hydroxylase activity Losses GO:0004370 glycerol kinase activity Losses GO:0008168 methyltransferase activity Losses GO:0005539 glycosaminoglycan binding Losses GO:0004303 estradiol 17-beta-dehydrogenase activity Losses GO:0016229 steroid dehydrogenase activity Losses GO:0016741 transferase activity, transferring one-carbon groups Losses GO:0005506 iron ion binding Losses GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups Losses GO:0004708 MAP kinase kinase activity Losses GO:0070891 lipoteichoic acid binding Losses GO:0030882 lipid antigen binding Losses GO:0046592 polyamine oxidase activity Losses GO:0038187 pattern recognition receptor activity Losses GO:0008329 signaling pattern recognition receptor activity Losses GO:0008174 mRNA methyltransferase activity Losses GO:0016491 oxidoreductase activity Losses GO:0004497 monooxygenase activity Losses GO:0004435 phosphatidylinositol phospholipase C activity Losses GO:0008649 rRNA methyltransferase activity Losses GO:0030247 polysaccharide binding Losses GO:0001871 pattern binding Losses GO:0140102 catalytic activity, acting on a rRNA Losses GO:0004312 fatty acid synthase activity Losses GO:0004197 cysteine-type endopeptidase activity Losses GO:0008135 translation factor activity, RNA binding Losses GO:0004629 phospholipase C activity Losses GO:0003823 antigen binding Losses GO:0031624 ubiquitin conjugating enzyme binding Losses GO:0016423 tRNA (guanine) methyltransferase activity Losses GO:0044390 ubiquitin-like protein conjugating enzyme binding Losses GO:0003924 GTPase activity Losses GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Losses GO:0070330 aromatase activity Losses GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Losses GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Losses GO:0016417 S-acyltransferase activity Losses GO:0005200 structural constituent of cytoskeleton Extinctions GO:0008270 zinc ion binding Extinctions GO:0008757 S-adenosylmethionine-dependent methyltransferase activity Extinctions GO:0008173 RNA methyltransferase activity Extinctions GO:0046914 transition metal ion binding Extinctions GO:0008168 methyltransferase activity Extinctions GO:0016741 transferase activity, transferring one-carbon groups Extinctions GO:0004708 MAP kinase kinase activity Extinctions GO:0008174 mRNA methyltransferase activity Extinctions GO:0005198 structural molecule activity Extinctions GO:0016417 S-acyltransferase activity Extinctions GO:0016423 tRNA (guanine) methyltransferase activity Extinctions GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors Extinctions GO:0016229 steroid dehydrogenase activity Extinctions GO:0003723 RNA binding Extinctions GO:0070567 cytidylyltransferase activity Extinctions GO:0003924 GTPase activity Extinctions GO:0019706 protein-cysteine S-palmitoyltransferase activity Extinctions GO:0019707 protein-cysteine S-acyltransferase activity Extinctions GO:0016836 hydro-lyase activity Extinctions GO:0004303 estradiol 17-beta-dehydrogenase activity Extinctions GO:0140030 modification-dependent protein binding Extinctions GO:0140034 methylation-dependent protein binding Extinctions GO:0035064 methylated histone binding Extinctions GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly Extinctions GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding Extinctions GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding Extinctions