GO:0034061 DNA polymerase activity Gains GO:0003964 RNA-directed DNA polymerase activity Gains GO:0003676 nucleic acid binding Gains GO:0003677 DNA binding Gains GO:0140097 catalytic activity, acting on DNA Gains GO:0097159 organic cyclic compound binding Gains GO:1901363 heterocyclic compound binding Gains GO:0008239 dipeptidyl-peptidase activity Gains GO:0005216 ion channel activity Gains GO:0022838 substrate-specific channel activity Gains GO:0022803 passive transmembrane transporter activity Gains GO:0015267 channel activity Gains GO:0005488 binding Gains GO:0042083 5,10-methylenetetrahydrofolate-dependent methyltransferase activity Gains GO:0003700 DNA binding transcription factor activity Gains GO:0004518 nuclease activity Gains GO:0022857 transmembrane transporter activity Gains GO:0016779 nucleotidyltransferase activity Gains GO:0140110 transcription regulator activity Gains GO:0004143 diacylglycerol kinase activity Gains GO:0015075 ion transmembrane transporter activity Gains GO:0070001 aspartic-type peptidase activity Gains GO:0004190 aspartic-type endopeptidase activity Gains GO:0008509 anion transmembrane transporter activity Gains GO:0015103 inorganic anion transmembrane transporter activity Gains GO:0005096 GTPase activator activity Gains GO:0035091 phosphatidylinositol binding Gains GO:0003951 NAD+ kinase activity Gains GO:0005230 extracellular ligand-gated ion channel activity Gains GO:0019239 deaminase activity Gains GO:0022891 substrate-specific transmembrane transporter activity Gains GO:0005215 transporter activity Gains GO:0008047 enzyme activator activity Gains GO:0016174 NAD(P)H oxidase activity Gains GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Gains GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor Gains GO:0008253 5'-nucleotidase activity Gains GO:0005254 chloride channel activity Gains GO:0005253 anion channel activity Gains GO:0030695 GTPase regulator activity Gains GO:0043169 cation binding Gains GO:0004016 adenylate cyclase activity Gains GO:0008525 phosphatidylcholine transporter activity Losses GO:0004714 transmembrane receptor protein tyrosine kinase activity Losses GO:0008395 steroid hydroxylase activity Losses GO:0019199 transmembrane receptor protein kinase activity Losses GO:0003964 RNA-directed DNA polymerase activity Losses GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity Losses GO:0070008 serine-type exopeptidase activity Losses GO:0034061 DNA polymerase activity Losses GO:0140097 catalytic activity, acting on DNA Losses GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen Losses GO:0005506 iron ion binding Losses GO:0016779 nucleotidyltransferase activity Losses GO:0004697 protein kinase C activity Losses GO:0046914 transition metal ion binding Losses GO:0046872 metal ion binding Losses GO:0003899 DNA-directed 5'-3' RNA polymerase activity Losses GO:1902936 phosphatidylinositol bisphosphate binding Losses GO:0043169 cation binding Losses GO:0033904 dextranase activity Losses GO:0032183 SUMO binding Losses GO:0004802 transketolase activity Losses GO:0070576 vitamin D 24-hydroxylase activity Losses GO:0070577 lysine-acetylated histone binding Losses GO:0016155 formyltetrahydrofolate dehydrogenase activity Losses GO:0005006 epidermal growth factor-activated receptor activity Losses GO:0004014 adenosylmethionine decarboxylase activity Losses GO:0042084 5-methyltetrahydrofolate-dependent methyltransferase activity Losses GO:0050699 WW domain binding Losses GO:0008426 protein kinase C inhibitor activity Losses GO:0140033 acetylation-dependent protein binding Losses GO:0005415 nucleoside:sodium symporter activity Losses GO:0032028 myosin head/neck binding Losses GO:0031489 myosin V binding Losses GO:0050072 m7G(5')pppN diphosphatase activity Losses GO:0030342 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity Losses GO:0005213 structural constituent of chorion Losses GO:0008705 methionine synthase activity Losses GO:0008873 gluconate 2-dehydrogenase activity Losses GO:0008875 gluconate dehydrogenase activity Losses GO:0008526 phosphatidylinositol transporter activity Losses GO:0004756 selenide, water dikinase activity Losses GO:0000404 heteroduplex DNA loop binding Losses GO:0000406 double-strand/single-strand DNA junction binding Losses GO:0070854 myosin VI heavy chain binding Losses GO:0070855 myosin VI head/neck binding Losses GO:0042767 ecdysteroid 22-hydroxylase activity Losses GO:0015370 solute:sodium symporter activity Losses GO:0016849 phosphorus-oxygen lyase activity Extinctions GO:0070576 vitamin D 24-hydroxylase activity Extinctions GO:0042084 5-methyltetrahydrofolate-dependent methyltransferase activity Extinctions GO:0005415 nucleoside:sodium symporter activity Extinctions GO:0050072 m7G(5')pppN diphosphatase activity Extinctions GO:0030342 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity Extinctions GO:0005213 structural constituent of chorion Extinctions GO:0008705 methionine synthase activity Extinctions GO:0003979 UDP-glucose 6-dehydrogenase activity Extinctions GO:0050824 water binding Extinctions GO:0050825 ice binding Extinctions GO:0047631 ADP-ribose diphosphatase activity Extinctions GO:0004411 homogentisate 1,2-dioxygenase activity Extinctions GO:0004791 thioredoxin-disulfide reductase activity Extinctions GO:0003777 microtubule motor activity Extinctions GO:0032129 histone deacetylase activity (H3-K9 specific) Extinctions GO:0004511 tyrosine 3-monooxygenase activity Extinctions GO:0004649 poly(ADP-ribose) glycohydrolase activity Extinctions GO:0005000 vasopressin receptor activity Extinctions GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) Extinctions GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) Extinctions GO:0043754 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity Extinctions GO:0031078 histone deacetylase activity (H3-K14 specific) Extinctions GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity Extinctions GO:0008140 cAMP response element binding protein binding Extinctions GO:0004357 glutamate-cysteine ligase activity Extinctions GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) Extinctions GO:0031419 cobalamin binding Extinctions GO:0008831 dTDP-4-dehydrorhamnose reductase activity Extinctions GO:0034739 histone deacetylase activity (H4-K16 specific) Extinctions GO:0003681 bent DNA binding Extinctions GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific) Extinctions