Domain arrangement Fusions Fissions Terminal losses Terminal emergences Single domain losses Single domain emergences PF00001 PF13917 1 0 0 0 0 0 PF00004 PF07724 PF10431 1 0 0 0 0 0 PF00005 PF12698 PF00005 0 1 0 0 0 0 PF00008 PF02210 PF00008 PF02210 1 0 2 0 0 0 PF00010 PF00989 PF08447 1 0 0 0 0 0 PF00012 PF00111 1 0 0 0 0 0 PF00028 PF00335 1 0 0 0 0 0 PF00046 PF00709 1 0 0 0 0 0 PF00058 PF14670 PF00058 PF00057 0 0 2 0 0 0 PF00063 PF00612 PF01576 1 0 1 0 0 0 PF00069 0 2 0 0 0 0 PF00069 PF01230 1 0 0 0 0 0 PF00071 PF07651 PF01608 1 0 0 0 0 0 PF00076 PF04935 1 0 0 0 0 0 PF00076 PF13893 1 0 0 0 0 0 PF00085 PF00076 1 0 0 0 0 0 PF00090 0 1 0 0 0 0 PF00090 PF00791 PF17217 PF00531 0 1 0 0 0 0 PF00090 PF05986 PF00090 PF08686 1 0 0 0 0 0 PF00096 PF12874 PF13894 1 0 0 0 0 0 PF00097 PF02037 1 0 0 0 0 0 PF00151 PF00089 1 0 0 0 0 0 PF00156 0 1 0 0 0 0 PF00169 PF01363 1 0 0 0 0 0 PF00171 0 1 0 0 0 0 PF00171 PF00465 1 0 0 0 0 0 PF00185 0 0 8 0 0 0 PF00194 PF02949 1 0 0 0 0 0 PF00202 PF00578 1 0 0 0 0 0 PF00203 PF00237 1 0 0 0 0 0 PF00215 0 1 0 0 0 0 PF00225 PF16183 0 1 7 0 0 0 PF00253 0 1 0 0 0 0 PF00268 PF02776 PF00205 PF02775 1 0 0 0 0 0 PF00270 PF00271 PF04408 PF07717 PF02949 1 0 0 0 0 0 PF00271 PF03368 PF02170 PF00636 0 1 0 0 0 0 PF00288 PF08544 0 0 1 0 0 0 PF00289 PF02786 PF02785 0 0 7 0 0 0 PF00291 PF00571 1 0 0 0 0 0 PF00293 PF00484 1 0 0 0 0 0 PF00293 PF04564 1 0 0 0 0 0 PF00307 0 1 0 0 0 0 PF00310 PF04898 PF01645 PF01493 PF14691 PF07992 1 0 0 0 0 0 PF00320 PF00105 PF00104 1 0 0 0 0 0 PF00344 0 0 1 0 0 0 PF00380 PF02798 PF00043 1 0 0 0 0 0 PF00415 PF13540 PF00415 0 1 0 0 0 0 PF00444 PF00416 1 0 0 0 0 0 PF00459 PF00151 1 0 0 0 0 0 PF00472 PF10234 1 0 0 0 0 0 PF00498 0 1 0 0 0 0 PF00535 PF01261 1 0 0 0 0 0 PF00550 PF00109 PF02801 1 0 0 0 0 0 PF00573 PF00276 1 0 0 0 0 0 PF00586 PF02769 PF00551 0 1 0 0 0 0 PF00621 0 1 0 0 0 0 PF00630 0 1 0 0 0 0 PF00640 0 1 0 0 0 0 PF00651 0 1 0 0 0 0 PF00651 PF12874 1 0 0 0 0 0 PF00651 PF14580 1 0 0 0 0 0 PF00687 PF00102 1 0 0 0 0 0 PF00688 PF00019 PF00688 PF00019 1 0 0 0 0 0 PF00696 0 1 0 0 0 0 PF00723 PF01757 1 0 0 0 0 0 PF00749 PF03950 0 0 2 0 0 0 PF00814 PF02214 1 0 0 0 0 0 PF00856 PF01145 1 0 0 0 0 0 PF00881 PF07992 1 0 0 0 0 0 PF00957 PF01776 1 0 0 0 0 0 PF00994 0 1 0 0 0 0 PF01027 PF14542 1 0 0 0 0 0 PF01094 PF07714 PF00211 PF04147 1 0 0 0 0 0 PF01111 PF00375 1 0 0 0 0 0 PF01146 PF02771 PF02770 PF00441 1 0 0 0 0 0 PF01159 0 0 1 0 0 0 PF01168 PF02594 1 0 0 0 0 0 PF01243 0 1 0 0 0 0 PF01266 0 1 0 0 0 0 PF01369 PF00169 1 0 0 0 0 0 PF01507 0 1 0 0 0 0 PF01553 PF00501 1 0 0 0 0 0 PF01553 PF07690 1 0 0 0 0 0 PF01557 PF08218 0 0 0 1 0 0 PF01562 PF01421 PF00090 PF05986 0 1 2 0 0 0 PF01607 PF01391 1 0 0 0 0 0 PF01612 PF03099 1 0 0 0 0 0 PF01753 PF00567 1 0 0 0 0 0 PF01779 0 0 0 0 1 0 PF01896 0 0 0 0 1 0 PF01963 PF05033 PF00856 1 0 0 0 0 0 PF01967 PF02391 1 0 0 0 0 0 PF02197 PF00612 1 0 0 0 0 0 PF02363 PF08395 1 0 0 0 0 0 PF02786 PF02785 PF00364 0 0 1 0 0 0 PF02815 0 0 1 0 0 0 PF02844 PF01071 PF02843 0 1 0 0 0 0 PF02949 PF01532 1 0 0 0 0 0 PF03022 PF00173 PF00487 1 0 0 0 0 0 PF03067 0 1 0 0 0 0 PF03564 0 0 0 0 1 0 PF03807 0 0 1 0 0 0 PF04095 PF01336 PF00152 1 0 0 0 0 0 PF04098 0 0 0 0 1 0 PF04241 0 1 0 0 0 0 PF04288 0 0 0 0 0 1 PF04420 0 0 0 0 1 0 PF04658 PF11027 1 0 0 0 0 0 PF04851 0 1 0 0 0 0 PF04851 PF00271 0 0 3 0 0 0 PF04979 PF03357 1 0 0 0 0 0 PF05485 PF00704 1 0 0 0 0 0 PF05839 0 0 0 0 1 0 PF05978 PF07690 1 0 0 0 0 0 PF06026 PF02826 1 0 0 0 0 0 PF06331 0 0 0 0 1 0 PF07022 0 0 0 0 0 1 PF07225 0 0 0 0 1 0 PF07297 0 0 0 0 1 0 PF07530 PF14529 1 0 0 0 0 0 PF07648 PF01650 1 0 0 0 0 0 PF07662 0 0 2 0 0 0 PF07679 PF13927 PF07679 PF13927 PF07679 PF00041 PF07679 PF00041 1 0 0 0 0 0 PF07686 PF07679 1 0 0 0 0 0 PF07686 PF13927 PF07679 1 0 0 0 0 0 PF07776 PF12874 PF13912 1 0 0 0 0 0 PF07776 PF13894 PF13912 PF00096 1 0 0 0 0 0 PF08144 0 0 0 0 1 0 PF08169 PF01388 0 0 1 0 0 0 PF08242 0 0 0 0 1 0 PF08311 0 1 0 0 0 0 PF08385 PF08393 PF12774 PF07728 0 0 8 0 0 0 PF08393 PF12774 PF07728 PF12775 0 0 4 0 0 0 PF08515 PF07714 0 0 1 0 0 0 PF08937 0 0 0 0 0 1 PF09371 PF16921 PF12836 PF00575 1 0 0 0 0 0 PF09791 PF00970 PF00175 1 0 0 0 0 0 PF10170 0 0 0 0 1 0 PF10177 0 1 0 0 0 0 PF10223 0 0 0 0 1 0 PF10545 PF02944 PF00067 1 0 0 0 0 0 PF10579 0 0 0 0 1 0 PF10590 0 1 0 0 0 0 PF10613 PF00060 PF00134 1 0 0 0 0 0 PF10713 0 0 0 0 0 1 PF11101 PF00763 PF02882 0 0 0 1 0 0 PF11577 0 0 1 0 0 0 PF11817 0 0 2 0 0 0 PF11830 PF00566 0 1 0 0 0 0 PF11878 PF00169 PF14429 PF06920 PF00653 PF13920 1 0 0 0 0 0 PF12328 0 0 0 0 1 0 PF12698 0 1 1 0 0 0 PF12706 0 0 1 0 0 0 PF12738 0 1 6 0 0 0 PF12738 PF00533 PF12738 0 1 0 0 0 0 PF12796 0 2 0 0 0 0 PF12796 PF00023 PF12796 PF00013 1 0 0 0 0 0 PF12796 PF00531 1 0 0 0 0 0 PF12874 PF00096 PF13894 1 0 0 0 0 0 PF12931 PF07304 1 0 0 0 0 0 PF13176 PF13181 PF13499 1 0 0 0 0 0 PF13181 0 1 0 0 0 0 PF13181 PF01753 1 0 0 0 0 0 PF13242 0 0 1 0 0 0 PF13414 PF13181 0 0 6 0 0 0 PF13417 0 1 0 0 0 0 PF13432 0 1 11 0 0 0 PF13528 PF00186 0 0 0 1 0 0 PF13593 0 1 0 0 0 0 PF13676 0 1 0 0 0 0 PF13833 PF13499 PF13202 PF13833 1 0 0 0 0 0 PF13843 0 0 0 0 1 0 PF13855 0 1 0 0 0 0 PF13895 0 1 0 0 0 0 PF13912 PF12874 PF13912 1 0 0 0 0 0 PF13923 PF16207 PF00134 1 0 0 0 0 0 PF13927 0 1 0 0 0 0 PF13927 PF07679 PF00041 0 1 0 0 0 0 PF14223 PF07885 1 0 0 0 0 0 PF14497 0 1 7 0 0 0 PF14786 0 0 0 0 1 0 PF14892 0 0 0 0 1 0 PF14932 0 0 0 0 1 0 PF14952 PF01849 1 0 0 0 0 0 PF14977 0 0 0 0 1 0 PF15055 0 0 0 0 1 0 PF15320 0 0 0 0 1 0 PF15323 0 0 0 0 1 0 PF15365 0 0 0 0 1 0 PF15388 0 0 0 0 1 0 PF15430 PF12796 1 0 0 0 0 0 PF15579 0 0 0 0 0 1 PF15619 0 0 0 0 1 0 PF15784 PF00249 1 0 0 0 0 0 PF15813 0 0 0 0 1 0 PF15990 0 0 0 0 1 0 PF16001 0 0 0 0 1 0 PF16038 0 0 0 0 1 0 PF16077 PF12259 1 0 0 0 0 0 PF16350 PF01571 PF08669 0 1 0 0 0 0 PF16486 PF08699 PF02170 PF16488 PF02171 PF00620 1 0 0 0 0 0 PF16740 0 1 0 0 0 0 PF16770 0 1 0 0 0 0 PF16808 PF00027 PF00069 1 0 0 0 0 0 PF17105 0 0 0 0 1 0 PF17110 PF00089 0 0 0 1 0 0 PF17135 0 1 0 0 0 0 PF17177 0 0 0 0 1 0