GO:0003824	catalytic activity	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0000156	phosphorelay response regulator activity	Gains
GO:0005549	odorant binding	Gains
GO:0004812	aminoacyl-tRNA ligase activity	Gains
GO:0048037	cofactor binding	Gains
GO:0036094	small molecule binding	Gains
GO:0140098	catalytic activity, acting on RNA	Gains
GO:0043168	anion binding	Gains
GO:0016763	transferase activity, transferring pentosyl groups	Gains
GO:0050662	coenzyme binding	Gains
GO:0050661	NADP binding	Gains
GO:0140101	catalytic activity, acting on a tRNA	Gains
GO:0030554	adenyl nucleotide binding	Gains
GO:0017076	purine nucleotide binding	Gains
GO:0005524	ATP binding	Gains
GO:0032559	adenyl ribonucleotide binding	Gains
GO:0032553	ribonucleotide binding	Gains
GO:0016741	transferase activity, transferring one-carbon groups	Gains
GO:0030145	manganese ion binding	Gains
GO:1901265	nucleoside phosphate binding	Gains
GO:0000166	nucleotide binding	Gains
GO:0030976	thiamine pyrophosphate binding	Gains
GO:0043115	precorrin-2 dehydrogenase activity	Gains
GO:0035639	purine ribonucleoside triphosphate binding	Gains
GO:0097367	carbohydrate derivative binding	Gains
GO:0032555	purine ribonucleotide binding	Gains
GO:0016462	pyrophosphatase activity	Gains
GO:0061783	peptidoglycan muralytic activity	Gains
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Gains
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	Gains
GO:0016817	hydrolase activity, acting on acid anhydrides	Gains
GO:0008173	RNA methyltransferase activity	Gains
GO:0008168	methyltransferase activity	Gains
GO:0043023	ribosomal large subunit binding	Gains
GO:0009922	fatty acid elongase activity	Gains
GO:0008169	C-methyltransferase activity	Gains
GO:0016829	lyase activity	Gains
GO:0017111	nucleoside-triphosphatase activity	Gains
GO:0016853	isomerase activity	Gains
GO:0019842	vitamin binding	Gains
GO:0043022	ribosome binding	Gains
GO:0016774	phosphotransferase activity, carboxyl group as acceptor	Gains
GO:0004654	polyribonucleotide nucleotidyltransferase activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0031406	carboxylic acid binding	Gains
GO:0043177	organic acid binding	Gains
GO:0140102	catalytic activity, acting on a rRNA	Gains
GO:0008649	rRNA methyltransferase activity	Gains
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Gains
GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
GO:0004813	alanine-tRNA ligase activity	Gains
GO:0002161	aminoacyl-tRNA editing activity	Gains
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Gains
GO:0016830	carbon-carbon lyase activity	Gains
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Gains
GO:0019205	nucleobase-containing compound kinase activity	Gains
GO:0004312	fatty acid synthase activity	Gains
GO:0016854	racemase and epimerase activity	Gains
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Gains
GO:0008028	monocarboxylic acid transmembrane transporter activity	Gains
GO:0019104	DNA N-glycosylase activity	Gains
GO:0030515	snoRNA binding	Gains
GO:0016776	phosphotransferase activity, phosphate group as acceptor	Gains
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Gains
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0004190	aspartic-type endopeptidase activity	Losses
GO:0070001	aspartic-type peptidase activity	Losses
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
GO:0004521	endoribonuclease activity	Losses
GO:0003676	nucleic acid binding	Losses
GO:0140097	catalytic activity, acting on DNA	Losses
GO:0004519	endonuclease activity	Losses
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0003677	DNA binding	Losses
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
GO:0004540	ribonuclease activity	Losses
GO:0008270	zinc ion binding	Losses
GO:0003723	RNA binding	Losses
GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
GO:0060089	molecular transducer activity	Losses
GO:0043565	sequence-specific DNA binding	Losses
GO:0004518	nuclease activity	Losses
GO:0043169	cation binding	Losses
GO:0003700	DNA binding transcription factor activity	Losses
GO:0004857	enzyme inhibitor activity	Losses
GO:0004526	ribonuclease P activity	Losses
GO:0032450	maltose alpha-glucosidase activity	Losses
GO:0097472	cyclin-dependent protein kinase activity	Losses
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Losses
GO:0046914	transition metal ion binding	Losses
GO:0004888	transmembrane signaling receptor activity	Losses
GO:0098772	molecular function regulator	Losses
GO:0030414	peptidase inhibitor activity	Losses
GO:0008527	taste receptor activity	Losses
GO:0090599	alpha-glucosidase activity	Losses
GO:0046872	metal ion binding	Losses
GO:0030234	enzyme regulator activity	Losses
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	Losses
GO:0038023	signaling receptor activity	Losses
GO:0099600	transmembrane receptor activity	Losses
GO:0061134	peptidase regulator activity	Losses
GO:0004803	transposase activity	Losses
GO:0004549	tRNA-specific ribonuclease activity	Losses
GO:0015926	glucosidase activity	Losses
GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Losses
GO:0005436	sodium:phosphate symporter activity	Losses
GO:0008873	gluconate 2-dehydrogenase activity	Losses
GO:0008875	gluconate dehydrogenase activity	Losses
GO:0003680	AT DNA binding	Losses
GO:0016208	AMP binding	Losses
GO:0032028	myosin head/neck binding	Losses
GO:0031489	myosin V binding	Losses
GO:0090600	alpha-1,3-glucosidase activity	Losses
GO:0016534	cyclin-dependent protein kinase 5 activator activity	Losses
GO:0070854	myosin VI heavy chain binding	Losses
GO:0070855	myosin VI head/neck binding	Losses
GO:0004995	tachykinin receptor activity	Losses
GO:0033919	glucan 1,3-alpha-glucosidase activity	Losses
GO:0033904	dextranase activity	Losses
GO:0052917	dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity	Losses
GO:0004866	endopeptidase inhibitor activity	Losses
GO:0004930	G-protein coupled receptor activity	Losses
GO:1901363	heterocyclic compound binding	Losses
GO:0097159	organic cyclic compound binding	Losses
GO:0031490	chromatin DNA binding	Losses
GO:0061135	endopeptidase regulator activity	Losses
GO:0008061	chitin binding	Losses
GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
GO:0005488	binding	Losses
GO:0008233	peptidase activity	Losses
GO:0004871	signal transducer activity	Losses
GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Losses
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0034061	DNA polymerase activity	Extinctions
GO:0004190	aspartic-type endopeptidase activity	Extinctions
GO:0070001	aspartic-type peptidase activity	Extinctions
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Extinctions
GO:0003676	nucleic acid binding	Extinctions
GO:0016798	hydrolase activity, acting on glycosyl bonds	Extinctions
GO:0004857	enzyme inhibitor activity	Extinctions
GO:0008061	chitin binding	Extinctions
GO:0098772	molecular function regulator	Extinctions
GO:0030234	enzyme regulator activity	Extinctions
GO:0003735	structural constituent of ribosome	Extinctions
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
GO:0008873	gluconate 2-dehydrogenase activity	Extinctions
GO:0008875	gluconate dehydrogenase activity	Extinctions
GO:0090600	alpha-1,3-glucosidase activity	Extinctions
GO:0016534	cyclin-dependent protein kinase 5 activator activity	Extinctions
GO:0033919	glucan 1,3-alpha-glucosidase activity	Extinctions
GO:0033904	dextranase activity	Extinctions
GO:0052917	dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity	Extinctions
GO:0003723	RNA binding	Extinctions
GO:0030414	peptidase inhibitor activity	Extinctions
GO:0016779	nucleotidyltransferase activity	Extinctions
GO:0140097	catalytic activity, acting on DNA	Extinctions
GO:0004867	serine-type endopeptidase inhibitor activity	Extinctions
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
GO:0004452	isopentenyl-diphosphate delta-isomerase activity	Extinctions
GO:0043539	protein serine/threonine kinase activator activity	Extinctions
GO:0004798	thymidylate kinase activity	Extinctions
GO:0019905	syntaxin binding	Extinctions
GO:0047710	bis(5'-adenosyl)-triphosphatase activity	Extinctions
GO:0000009	alpha-1,6-mannosyltransferase activity	Extinctions
GO:0061134	peptidase regulator activity	Extinctions
GO:0004842	ubiquitin-protein transferase activity	Extinctions
GO:0097472	cyclin-dependent protein kinase activity	Extinctions
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Extinctions
GO:0019787	ubiquitin-like protein transferase activity	Extinctions
GO:0005509	calcium ion binding	Extinctions
GO:0004521	endoribonuclease activity	Extinctions
GO:0003677	DNA binding	Extinctions