EOG8DV82W	GO:0080019	172/601	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8DV82W	GO:0004043	6/601	L-aminoadipate-semialdehyde dehydrogenase activity	molecular_function	"Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31]
EOG8DV82W	GO:0010025	2/601	wax biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids." [ISBN:0943088399]
EOG8DV82W	GO:0006629	2/601	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8DV82W	GO:0016021	2/601	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DV82W	GO:0050062	2/601	long-chain-fatty-acyl-CoA reductase activity	molecular_function	"Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH." [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN]
EOG8DV82W	GO:0005777	2/601	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8DV82W	GO:0000166	1/601	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8DV82W	GO:0003676	1/601	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DV82W	GO:0005778	1/601	peroxisomal membrane	cellular_component	"The lipid bilayer surrounding a peroxisome." [GOC:mah]
EOG8DV82W	GO:0008340	1/601	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8DV82W	GO:0006909	1/601	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8DV82W	GO:0016746	1/601	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8XPSZV	GO:0003677	197/409	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XPSZV	GO:0000786	197/409	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8XPSZV	GO:0006334	197/409	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8XPSZV	GO:0005634	196/409	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XPSZV	GO:0032008	25/409	positive regulation of TOR signaling	biological_process	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8XPSZV	GO:0071230	25/409	cellular response to amino acid stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:mah]
EOG8XPSZV	GO:0032439	22/409	endosome localization	biological_process	"Any process in which endosomes are transported to, and/or maintained in, a specific location within the cell." [GOC:ecd]
EOG8XPSZV	GO:0007040	22/409	lysosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]
EOG8XPSZV	GO:0001919	22/409	regulation of receptor recycling	biological_process	"Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add]
EOG8XPSZV	GO:0071986	22/409	Ragulator complex	cellular_component	"A protein complex that contains MAPKSP1 (MP1, Map2k1ip1), ROBLD3 (p14, Mapbpip), C11orf59 (p18), LAMTOR4 and LAMTOR5. The complex is anchored to lipid rafts in late endosome membranes via C11orf59, recruits mTORC1 to lysosomal membranes in amino acid signaling to mTORC1, constitutes a guanine nucleotide exchange factor (GEF) for the Rag GTPases, and is also involved in ERK/MAPK signaling." [GOC:lb, PMID:19177150, PMID:20381137, PMID:22980980]
EOG8XPSZV	GO:0042632	22/409	cholesterol homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]
EOG8XPSZV	GO:0043410	22/409	positive regulation of MAPK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]
EOG8XPSZV	GO:0031902	3/409	late endosome membrane	cellular_component	"The lipid bilayer surrounding a late endosome." [GOC:pz]
EOG8XPSZV	GO:0003964	1/409	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8XPSZV	GO:0003723	1/409	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8XPSZJ	GO:0004129	51/145	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8XPSZJ	GO:0005751	51/145	mitochondrial respiratory chain complex IV	cellular_component	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]
EOG8XPSZJ	GO:0008340	1/145	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8XPSZJ	GO:0005811	1/145	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8XPSZJ	GO:0006123	1/145	mitochondrial electron transport, cytochrome c to oxygen	biological_process	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]
EOG8XPSZJ	GO:0050790	1/145	regulation of catalytic activity	biological_process	"Any process that modulates the activity of an enzyme." [GOC:ai]
EOG8XPSZJ	GO:1902600	1/145	hydrogen ion transmembrane transport	biological_process	"The directed movement of hydrogen ion (proton) across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
EOG8XPSZJ	GO:0030234	1/145	enzyme regulator activity	molecular_function	"Binds to and modulates the activity of an enzyme." [GOC:mah]
EOG822CZV	GO:0016021	46/145	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG822CZV	GO:0055085	39/145	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG822CZV	GO:0022857	7/145	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG822CZV	GO:0046331	1/145	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG822CZV	GO:0003676	1/145	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG822CZV	GO:0016298	1/145	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG822CZV	GO:0008270	1/145	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG822CZV	GO:0006629	1/145	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8W9MK7	GO:0004252	16/62	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8W9MK7	GO:0016021	1/62	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SXQSB	GO:0005524	1/30	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SXQSB	GO:0004672	1/30	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8SXQSM	GO:0005319	38/153	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG8SXQSM	GO:0006801	5/153	superoxide metabolic process	biological_process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl]
EOG8SXQSM	GO:0046872	5/153	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8SXQSM	GO:0055114	5/153	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG879HP9	GO:0004035	127/508	alkaline phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1]
EOG879HP9	GO:0016791	75/508	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG879HP9	GO:0035094	1/508	response to nicotine	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [CHEBI:17688, GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089]
EOG879HP9	GO:0003824	1/508	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG879HP9	GO:0016021	1/508	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG879HP9	GO:0005576	1/508	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG879HP9	GO:0005615	1/508	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG879HP9	GO:0031225	1/508	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG879HP9	GO:0046872	1/508	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG879HP9	GO:0007399	1/508	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG879HP9	GO:0032504	1/508	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG879HP9	GO:0042045	1/508	epithelial fluid transport	biological_process	"The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830]
EOG879HP9	GO:0005886	1/508	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8WHC32	GO:0008613	1/81	diuretic hormone activity	molecular_function	"The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion." [GOC:mah, InterPro:IPR003621, PMID:8618894]
EOG8WHC32	GO:0005184	1/81	neuropeptide hormone activity	molecular_function	"The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]
EOG8WHC32	GO:0001664	1/81	G-protein coupled receptor binding	molecular_function	"Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph]
EOG8WHC32	GO:0005576	1/81	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8WHC32	GO:0010579	1/81	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	biological_process	"Any process that increases the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G-protein coupled receptor signaling pathway." [GOC:dph, GOC:signaling, GOC:tb]
EOG8WHC32	GO:0007589	1/81	body fluid secretion	biological_process	"The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb]
EOG8WHC32	GO:0007218	1/81	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8WHC32	GO:0007186	1/81	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8J6V63	GO:0008234	42/98	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8J6V63	GO:0000338	1/98	protein deneddylation	biological_process	"The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]
EOG8J6V63	GO:0019784	1/98	NEDD8-specific protease activity	molecular_function	"Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates." [GOC:mah]
EOG8J6V63	GO:0043065	1/98	positive regulation of apoptotic process	biological_process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8J6V66	GO:0016021	25/81	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J6V66	GO:0006810	24/81	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8J6V66	GO:0070863	1/81	positive regulation of protein exit from endoplasmic reticulum	biological_process	"Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum." [GOC:mah]
EOG8J6V66	GO:0005215	1/81	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8J6V66	GO:0090263	1/81	positive regulation of canonical Wnt signaling pathway	biological_process	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]
EOG8J6V66	GO:0061357	1/81	positive regulation of Wnt protein secretion	biological_process	"Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
EOG8J6V66	GO:0048042	1/81	regulation of post-mating oviposition	biological_process	"Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb, PMID:11932766]
EOG8J6V66	GO:0035220	1/81	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8J6V66	GO:0006888	1/81	ER to Golgi vesicle-mediated transport	biological_process	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]
EOG8J6V66	GO:0048193	1/81	Golgi vesicle transport	biological_process	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG8J6V66	GO:0000003	1/81	reproduction	biological_process	"The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732]
EOG8WQ3HX	GO:0006915	31/91	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8WQ3HX	GO:0004197	31/91	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8WQ3HX	GO:0005622	8/91	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8WQ3HX	GO:0042981	8/91	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8WQ3HX	GO:0008285	1/91	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8WQ3HX	GO:0031638	1/91	zymogen activation	biological_process	"The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd]
EOG8WQ3HX	GO:0010506	1/91	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8WQ3HX	GO:0005737	1/91	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WQ3HX	GO:0012501	1/91	programmed cell death	biological_process	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]
EOG8WQ3HX	GO:0042803	1/91	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8WQ3HX	GO:0016540	1/91	protein autoprocessing	biological_process	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]
EOG8WQ3HX	GO:0035234	1/91	ectopic germ cell programmed cell death	biological_process	"Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944]
EOG8WQ3HX	GO:0046668	1/91	regulation of retinal cell programmed cell death	biological_process	"Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
EOG8WQ3HX	GO:0007552	1/91	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG8WQ3HX	GO:0048813	1/91	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8WQ3HX	GO:0008258	1/91	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8WQ3HX	GO:0004175	1/91	endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8WQ3HX	GO:0046672	1/91	positive regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG8WQ3HX	GO:0007291	1/91	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8WQ3HX	GO:0006919	1/91	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
EOG8WQ3HX	GO:0010623	1/91	developmental programmed cell death	biological_process	"The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:tb]
EOG8WQ3HX	GO:0007516	1/91	hemocyte development	biological_process	"The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG8WQ3HX	GO:0007417	1/91	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8WQ3HX	GO:0007423	1/91	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8WQ3HX	GO:0016322	1/91	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG8WQ3HX	GO:0045476	1/91	nurse cell apoptotic process	biological_process	"Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306]
EOG8WQ3HX	GO:0048749	1/91	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8WQ3HX	GO:0035071	1/91	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8WQ3HX	GO:0005515	1/91	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8WQ3HX	GO:0035070	1/91	salivary gland histolysis	biological_process	"The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683]
EOG8WQ3HX	GO:0001700	1/91	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8WQ3HX	GO:0010941	1/91	regulation of cell death	biological_process	"Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]
EOG8WQ3HX	GO:0008340	1/91	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8WQ3HX	GO:0048102	1/91	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8J6V68	GO:0006810	1/87	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8J6V68	GO:0016021	1/87	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WQ3HZ	GO:0016021	2/55	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WQ3HZ	GO:0008137	1/55	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8WQ3HZ	GO:0045263	1/55	proton-transporting ATP synthase complex, coupling factor F(o)	cellular_component	"All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056]
EOG8WQ3HZ	GO:0070469	1/55	respiratory chain	cellular_component	"The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684]
EOG8WQ3HZ	GO:0055114	1/55	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8WQ3HZ	GO:0015986	1/55	ATP synthesis coupled proton transport	biological_process	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]
EOG8WQ3HZ	GO:0016020	1/55	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8WQ3HZ	GO:0005743	1/55	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8WQ3HZ	GO:0022904	1/55	respiratory electron transport chain	biological_process	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]
EOG8WQ3HZ	GO:0015078	1/55	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG8WQ3HZ	GO:0050136	1/55	NADH dehydrogenase (quinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol." [EC:1.6.99.5, GOC:mah, MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN]
EOG8NP9J2	GO:0016021	6/38	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VQD62	GO:0003677	1/9	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8W9MKW	GO:0005743	1/84	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8WM77W	GO:0008270	7/106	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WM77W	GO:0003676	2/106	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WM77W	GO:0010212	1/106	response to ionizing radiation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526]
EOG8WM77W	GO:0006260	1/106	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8WM77W	GO:0005634	1/106	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WM77W	GO:0015074	1/106	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8WM77W	GO:0033314	1/106	mitotic DNA replication checkpoint	biological_process	"A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mtg_cell_cycle]
EOG8V45QS	GO:0007219	2/34	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8V45QS	GO:0016021	2/34	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V45QS	GO:0007275	2/34	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8WQ3H3	GO:0015031	27/92	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8WQ3H3	GO:0006464	27/92	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG8WQ3H3	GO:0005525	3/92	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8WQ3H3	GO:0036258	1/92	multivesicular body assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [GOC:sart, PMID:11566881, PMID:19571114]
EOG8WQ3H3	GO:0000813	1/92	ESCRT I complex	cellular_component	"An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
EOG8WQ3H3	GO:0045571	1/92	negative regulation of imaginal disc growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators]
EOG8WQ3H3	GO:0005515	1/92	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8WQ3H3	GO:0007430	1/92	terminal branching, open tracheal system	biological_process	"Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG8WQ3H3	GO:0060439	1/92	trachea morphogenesis	biological_process	"The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG8WQ3H3	GO:0044130	1/92	negative regulation of growth of symbiont in host	biological_process	"Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
EOG8WQ3H3	GO:0035090	1/92	maintenance of apical/basal cell polarity	biological_process	"Retaining the established polarization of a cell along its apical/basal axis." [GOC:bf]
EOG8WQ3H3	GO:0032509	1/92	endosome transport via multivesicular body sorting pathway	biological_process	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]
EOG879HPG	GO:0003676	12/105	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG879HPG	GO:0022008	1/105	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8W9MKD	GO:0004719	26/111	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77]
EOG8W9MKD	GO:0005737	1/111	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8W9MKD	GO:0006479	1/111	protein methylation	biological_process	"The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai]
EOG8W9MKD	GO:0042742	1/111	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8NP9JX	GO:0046872	14/78	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NP9JW	GO:0007264	6/40	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8NP9JW	GO:0005525	6/40	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8GB9N0	GO:0051205	3/26	protein insertion into membrane	biological_process	"The process that results in the incorporation of a protein into a biological membrane.  Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]
EOG8GB9N0	GO:0016021	3/26	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GB9N5	GO:0005524	29/125	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8GB9N5	GO:0004674	26/125	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8GB9N5	GO:0004693	4/125	cyclin-dependent protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]
EOG8GB9N5	GO:0006468	1/125	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8GB9N5	GO:0000281	1/125	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8GB9N5	GO:0051301	1/125	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8WDGV7	GO:0042302	184/825	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8WDGV7	GO:0040003	5/825	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8WDGV7	GO:0031012	5/825	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8WDGV7	GO:0008010	5/825	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8WDGV7	GO:0022008	1/825	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8D2943	GO:0016787	1/85	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8D2943	GO:0047617	1/85	acyl-CoA hydrolase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate." [EC:3.1.2.20, MetaCyc:ACYL-COA-HYDROLASE-RXN]
EOG8FJBQJ	GO:0004064	2/99	arylesterase activity	molecular_function	"Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2]
EOG8FJBQJ	GO:0016021	1/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FJBQJ	GO:1901739	1/99	regulation of myoblast fusion	biological_process	"Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]
EOG8WSZSF	GO:0016272	26/74	prefoldin complex	cellular_component	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]
EOG8WSZSF	GO:0006457	26/74	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8WSZSF	GO:0006909	1/74	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8WSZSF	GO:0048477	1/74	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8T1M38	GO:0016021	25/54	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KM1GT	GO:0003777	1/37	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8KM1GT	GO:0005871	1/37	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8KM1GT	GO:0007018	1/37	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8KM1GT	GO:0005524	1/37	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KM1GT	GO:0005874	1/37	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG818F3Q	GO:0008080	33/135	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG818F3Q	GO:0016740	3/135	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG818F3Q	GO:0030431	1/135	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG818F3Q	GO:0048066	1/135	developmental pigmentation	biological_process	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
EOG818F3Q	GO:0004060	1/135	arylamine N-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine." [EC:2.3.1.5]
EOG818F3Q	GO:0045187	1/135	regulation of circadian sleep/wake cycle, sleep	biological_process	"Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981]
EOG818F3Q	GO:0042420	1/135	dopamine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
EOG818F3Q	GO:0006584	1/135	catecholamine metabolic process	biological_process	"The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
EOG818F3Q	GO:0042429	1/135	serotonin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
EOG818F3Q	GO:0046334	1/135	octopamine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732]
EOG818F3Q	GO:0004059	1/135	aralkylamine N-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87]
EOG818F3Q	GO:0030187	1/135	melatonin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732]
EOG818F3Q	GO:0005737	1/135	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8S7N4Q	GO:0008484	81/332	sulfuric ester hydrolase activity	molecular_function	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]
EOG8S7N4Q	GO:0003943	34/332	N-acetylgalactosamine-4-sulfatase activity	molecular_function	"Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12]
EOG8S7N4Q	GO:0008270	1/332	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8S7N4Q	GO:0042742	1/332	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG87DCWN	GO:0016772	137/261	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG812PMN	GO:0008060	23/93	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG812PMN	GO:0032312	23/93	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG812PMN	GO:0008270	23/93	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG812PMN	GO:0046331	1/93	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG812PMN	GO:0001745	1/93	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG812PMN	GO:0005737	1/93	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG812PMN	GO:0043547	1/93	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG812PMJ	GO:0016491	24/91	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG812PMJ	GO:0046872	21/91	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG812PMJ	GO:0051537	21/91	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG812PMJ	GO:0008137	2/91	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG812PMJ	GO:0009055	1/91	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG812PMJ	GO:0006120	1/91	mitochondrial electron transport, NADH to ubiquinone	biological_process	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363]
EOG812PMJ	GO:0005739	1/91	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG812PMJ	GO:0005747	1/91	mitochondrial respiratory chain complex I	cellular_component	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]
EOG8S7N41	GO:0000166	18/85	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8S7N41	GO:0046872	2/85	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8S7N41	GO:0008270	1/85	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CC6JB	GO:0016021	1/60	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8N5ZBP	GO:0050661	42/135	NADP binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]
EOG8N5ZBP	GO:0006006	42/135	glucose metabolic process	biological_process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]
EOG8N5ZBP	GO:0051287	42/135	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8N5ZBP	GO:0004365	32/135	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	molecular_function	"Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12]
EOG8N5ZBP	GO:0016620	14/135	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG8N5ZBP	GO:0006096	3/135	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8N5ZBP	GO:0005737	2/135	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8N5ZBP	GO:0005811	2/135	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8N5ZBP	GO:0030018	1/135	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8N5ZBP	GO:0005875	1/135	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8N5ZBP	GO:0031430	1/135	M band	cellular_component	"The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194]
EOG844P35	GO:0072588	26/84	box H/ACA RNP complex	cellular_component	"A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex." [GOC:BHF, GOC:BHF_telomerase, GOC:jbu, GOC:mah, GOC:vw, PMID:17284456, PMID:20227365]
EOG844P35	GO:0001522	26/84	pseudouridine synthesis	biological_process	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]
EOG844P35	GO:0030515	26/84	snoRNA binding	molecular_function	"Interacting selectively and non-covalently with small nucleolar RNA." [GOC:mah]
EOG844P35	GO:0042254	25/84	ribosome biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
EOG844P35	GO:0019013	4/84	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG844P35	GO:0006364	1/84	rRNA processing	biological_process	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
EOG844P35	GO:0005730	1/84	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG812PMQ	GO:0004298	28/92	threonine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG812PMQ	GO:0005839	28/92	proteasome core complex	cellular_component	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]
EOG812PMQ	GO:0051603	27/92	proteolysis involved in cellular protein catabolic process	biological_process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]
EOG812PMQ	GO:0005634	8/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG812PMQ	GO:0005737	8/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG812PMQ	GO:0043161	1/92	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG812PMQ	GO:0000502	1/92	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG812PMQ	GO:0016787	1/92	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8ZCWND	GO:0003713	9/57	transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8ZCWND	GO:0006355	9/57	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8ZCWND	GO:0004402	1/57	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8T1M3D	GO:0016021	24/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8T1M3D	GO:0005737	23/91	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8T1M3D	GO:0016627	23/91	oxidoreductase activity, acting on the CH-CH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8T1M3D	GO:0006629	23/91	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8T1M3D	GO:0005789	1/91	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8T1M3D	GO:0019348	1/91	dolichol metabolic process	biological_process	"The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732]
EOG8T1M3D	GO:0006486	1/91	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8T1M3D	GO:0006488	1/91	dolichol-linked oligosaccharide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309]
EOG8T1M3D	GO:0016095	1/91	polyprenol catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators, http://www.chem.qmul.ac.uk/iupac/misc/prenol.html#p2]
EOG8T1M3D	GO:0003865	1/91	3-oxo-5-alpha-steroid 4-dehydrogenase activity	molecular_function	"Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5]
EOG818F39	GO:0016021	4/43	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG818F39	GO:0004930	4/43	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG818F39	GO:0007218	1/43	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8T1M3V	GO:0010507	1/72	negative regulation of autophagy	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8T1M3V	GO:0048812	1/72	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG86Q96V	GO:0016772	12/72	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG841SST	GO:0006909	1/85	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8V45Q7	GO:0008270	23/150	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V45Q7	GO:0016787	22/150	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8V45Q7	GO:0003908	1/150	methylated-DNA-[protein]-cysteine S-methyltransferase activity	molecular_function	"Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63]
EOG8V45Q7	GO:0016798	1/150	hydrolase activity, acting on glycosyl bonds	molecular_function	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]
EOG8V45Q7	GO:0004131	1/150	cytosine deaminase activity	molecular_function	"Catalysis of the reaction: cytosine + H2O = uracil + NH3." [EC:3.5.4.1]
EOG8N06XJ	GO:0005634	5/36	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8N06XJ	GO:0006355	5/36	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8N06XJ	GO:0016747	5/36	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8ZGRTH	GO:0003935	1/14	GTP cyclohydrolase II activity	molecular_function	"Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+)." [EC:3.5.4.25, RHEA:23707]
EOG8ZGRTH	GO:0009231	1/14	riboflavin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
EOG8ZGRTD	GO:0016021	22/92	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZGRTD	GO:0005918	1/92	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG8ZGRTD	GO:0007476	1/92	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8ZGRTC	GO:0004930	1/20	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8ZGRTC	GO:0004984	1/20	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8ZGRTC	GO:0016021	1/20	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZGRTC	GO:0005549	1/20	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8KSRZK	GO:0005524	11/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KSRZK	GO:0004674	9/91	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8KSRZK	GO:0004687	1/91	myosin light chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18]
EOG8KSRZK	GO:0004672	1/91	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG88PQ12	GO:0007165	2/96	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG88PQ14	GO:0004527	2/86	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG88PQ14	GO:0005652	1/86	nuclear lamina	cellular_component	"The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363]
EOG88PQ14	GO:0000176	1/86	nuclear exosome (RNase complex)	cellular_component	"Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]
EOG88PQ14	GO:0016787	1/86	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG88PQ14	GO:0005737	1/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG88PQ14	GO:0022008	1/86	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG88PQ17	GO:0006412	24/85	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG88PQ17	GO:0003735	24/85	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG88PQ17	GO:0005840	23/85	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG88PQ17	GO:0019843	2/85	rRNA binding	molecular_function	"Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl]
EOG88PQ17	GO:0008361	1/85	regulation of cell size	biological_process	"Any process that modulates the size of a cell." [GOC:go_curators]
EOG88PQ17	GO:0007052	1/85	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG88PQ17	GO:0000022	1/85	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG88PQ17	GO:0005737	1/85	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG88PQ17	GO:0005730	1/85	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG88PQ17	GO:0048749	1/85	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG88PQ17	GO:0008286	1/85	insulin receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]
EOG88PQ17	GO:0000228	1/85	nuclear chromosome	cellular_component	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
EOG88PQ17	GO:0051298	1/85	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG88PQ17	GO:0015934	1/85	large ribosomal subunit	cellular_component	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]
EOG89PDFX	GO:0004721	1/64	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG86DPJ9	GO:0016021	7/45	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D55C9	GO:0004109	26/86	coproporphyrinogen oxidase activity	molecular_function	"Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX." [EC:1.3.3.3, RHEA:18260]
EOG8D55C9	GO:0006779	25/86	porphyrin-containing compound biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732]
EOG8D55C9	GO:0042803	1/86	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8D55C9	GO:0006782	1/86	protoporphyrinogen IX biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX." [GOC:go_curators]
EOG89CSNM	GO:0022008	1/89	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG89CSNM	GO:0034472	1/89	snRNA 3'-end processing	biological_process	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]
EOG89CSNM	GO:0016180	1/89	snRNA processing	biological_process	"Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule." [GOC:jl]
EOG8D55C1	GO:0005524	27/90	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8D55C1	GO:0004674	27/90	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8D55C1	GO:0007391	1/90	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8D55C1	GO:0045201	1/90	maintenance of neuroblast polarity	biological_process	"The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]
EOG8D55C1	GO:0007052	1/90	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8D55C1	GO:0005737	1/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8D55C1	GO:0016325	1/90	oocyte microtubule cytoskeleton organization	biological_process	"Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]
EOG8D55C1	GO:0004672	1/90	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8D55C1	GO:0007163	1/90	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8D55C1	GO:0005634	1/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D55C1	GO:0046328	1/90	regulation of JNK cascade	biological_process	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8D55C1	GO:0045451	1/90	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8D55C1	GO:0006468	1/90	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8D55C1	GO:0008340	1/90	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8D55C1	GO:0043065	1/90	positive regulation of apoptotic process	biological_process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8D55C1	GO:0055059	1/90	asymmetric neuroblast division	biological_process	"The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
EOG8D55C1	GO:0030709	1/90	border follicle cell delamination	biological_process	"The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261]
EOG89PDFN	GO:0005549	1/113	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG88PQ1Q	GO:0006396	23/91	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG88PQ1Q	GO:0071013	1/91	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG88PQ1Q	GO:0000398	1/91	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG88PQ1Q	GO:0071011	1/91	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8W10SX	GO:0005524	13/74	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8W10SX	GO:0003676	13/74	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W10SX	GO:0008026	11/74	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8W10SX	GO:0004386	2/74	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8D55CX	GO:0016021	23/90	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D55CX	GO:0016746	2/90	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8D55CX	GO:0007367	1/90	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG8D55CX	GO:0018345	1/90	protein palmitoylation	biological_process	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]
EOG8D55CX	GO:0018009	1/90	N-terminal peptidyl-L-cysteine N-palmitoylation	biological_process	"The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal cysteine residue to form N-palmitoyl-L-cysteine." [RESID:AA0060]
EOG8D55CX	GO:0016409	1/90	palmitoyltransferase activity	molecular_function	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]
EOG8D55CX	GO:0007224	1/90	smoothened signaling pathway	biological_process	"A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
EOG8D55CX	GO:0016740	1/90	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8J400F	GO:0046872	19/98	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84J4ZX	GO:0046872	52/224	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84J4ZX	GO:0016787	45/224	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG84J4ZX	GO:0004177	13/224	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG84J4ZX	GO:0005829	1/224	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG84J4ZX	GO:0006508	1/224	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG84J4ZX	GO:0022008	1/224	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84J4ZX	GO:0070006	1/224	metalloaminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG87DCX7	GO:0008061	105/374	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG87DCX7	GO:0006030	105/374	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG87DCX7	GO:0005576	103/374	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG87DCX7	GO:0005615	2/374	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG87DCX7	GO:0010716	1/374	negative regulation of extracellular matrix disassembly	biological_process	"Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
EOG87DCX7	GO:0032504	1/374	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG87DCX7	GO:0040003	1/374	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG84J4ZS	GO:0031965	2/82	nuclear membrane	cellular_component	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
EOG84J4ZS	GO:0005643	2/82	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG84J4ZS	GO:0015031	2/82	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84J4ZS	GO:0051028	2/82	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84J4ZS	GO:0022008	1/82	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8ZGRT0	GO:0015991	31/102	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8ZGRT0	GO:0015078	30/102	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG8ZGRT0	GO:0033179	30/102	proton-transporting V-type ATPase, V0 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG8ZGRT0	GO:0016787	2/102	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8ZGRT0	GO:0033181	1/102	plasma membrane proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
EOG8ZGRT0	GO:0000220	1/102	vacuolar proton-transporting V-type ATPase, V0 domain	cellular_component	"The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG8ZGRT0	GO:0046961	1/102	proton-transporting ATPase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]
EOG8ZGRT0	GO:0007035	1/102	vacuolar acidification	biological_process	"Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid]
EOG8ZGRT0	GO:0008593	1/102	regulation of Notch signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8ZGRT0	GO:0005886	1/102	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8H74RC	GO:0016021	8/36	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8H74RC	GO:0005524	8/36	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8H74RC	GO:0042626	8/36	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8H74RC	GO:0032440	1/36	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8H74RB	GO:0005509	7/54	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8H74RB	GO:0004523	1/54	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8H74RB	GO:0003676	1/54	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V71XG	GO:0005737	26/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8V71XG	GO:0009264	26/89	deoxyribonucleotide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
EOG8V71XG	GO:0004139	26/89	deoxyribose-phosphate aldolase activity	molecular_function	"Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4, RHEA:12824]
EOG8T7BJZ	GO:0004842	21/85	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8T7BJZ	GO:0006281	21/85	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8T7BJZ	GO:0043240	21/85	Fanconi anaemia nuclear complex	cellular_component	"A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]
EOG8T7BJZ	GO:0008270	10/85	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8T7BJZ	GO:0016020	1/85	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8T7BJZ	GO:0006513	1/85	protein monoubiquitination	biological_process	"Addition of a single ubiquitin group to a protein." [GOC:ai]
EOG8T7BJZ	GO:0005044	1/85	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8T7BJZ	GO:0046872	1/85	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8T7BJZ	GO:0030246	1/85	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8T7BJZ	GO:0008168	1/85	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8KSS25	GO:0005622	4/16	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8KSS25	GO:0007264	4/16	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8KSS25	GO:0005085	4/16	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG805VGX	GO:0008270	24/86	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG805VGX	GO:0005779	24/86	integral component of peroxisomal membrane	cellular_component	"The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah]
EOG805VGX	GO:0006625	24/86	protein targeting to peroxisome	biological_process	"The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai]
EOG805VGX	GO:0007286	1/86	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG805VGX	GO:0007031	1/86	peroxisome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
EOG805VGX	GO:0048137	1/86	spermatocyte division	biological_process	"The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238]
EOG8V71XT	GO:0003755	65/213	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8V71XT	GO:0006457	65/213	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8V71XT	GO:0000166	26/213	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8V71XT	GO:0003723	21/213	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8V71XT	GO:0003676	4/213	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V71XT	GO:0003729	1/213	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8V71XT	GO:0042277	1/213	peptide binding	molecular_function	"Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds." [GOC:jl]
EOG8V71XT	GO:0071013	1/213	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8V71XT	GO:0000398	1/213	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8V71XT	GO:0005829	1/213	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8V71XT	GO:0016853	1/213	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8V71XT	GO:0000413	1/213	protein peptidyl-prolyl isomerization	biological_process	"The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570]
EOG8V71XT	GO:0071011	1/213	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8V71XT	GO:0035071	1/213	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8V71XT	GO:0048102	1/213	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8V71XT	GO:0006909	1/213	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8V71XT	GO:0005515	1/213	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8V71XT	GO:0005875	1/213	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8577PS	GO:0016021	7/30	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V19FS	GO:0016787	15/283	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8V19FS	GO:0050357	6/283	tropinesterase activity	molecular_function	"Catalysis of the reaction: atropine + H(2)O = H(+) + tropate + tropine." [EC:3.1.1.10, RHEA:23307]
EOG8V19FS	GO:0007275	1/283	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8V19FS	GO:0003676	1/283	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V19FS	GO:0017171	1/283	serine hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [Wikipedia:Serine_hydrolase]
EOG8V19FS	GO:0000166	1/283	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8V19FS	GO:0007586	1/283	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG8V19FS	GO:0008152	1/283	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8V19FS	GO:0009636	1/283	response to toxic substance	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr]
EOG8ZKN2M	GO:0005576	20/83	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8ZKN2M	GO:0006629	20/83	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8ZKN2M	GO:0016787	14/83	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8ZKN2M	GO:0003824	4/83	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8ZKN2M	GO:0008270	1/83	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZKN2M	GO:0004806	1/83	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG8ZKN2M	GO:0004222	1/83	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8NP9JF	GO:0016787	1/91	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8ZKN2G	GO:0016021	49/117	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZKN2G	GO:0006810	45/117	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8ZKN2G	GO:0055085	4/117	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8V19FD	GO:0050661	38/115	NADP binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]
EOG8V19FD	GO:0045454	38/115	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8V19FD	GO:0004791	38/115	thioredoxin-disulfide reductase activity	molecular_function	"Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide." [EC:1.8.1.9, RHEA:20348]
EOG8V19FD	GO:0050660	38/115	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8V19FD	GO:0009055	5/115	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8V19FD	GO:0015035	5/115	protein disulfide oxidoreductase activity	molecular_function	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]
EOG8V19FD	GO:0004362	4/115	glutathione-disulfide reductase activity	molecular_function	"Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732]
EOG8V19FD	GO:0005739	2/115	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8V19FD	GO:0042803	1/115	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8V19FD	GO:0001666	1/115	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG8V19FD	GO:0005875	1/115	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8V19FD	GO:0008340	1/115	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8V19FD	GO:0006974	1/115	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8V19FD	GO:0022008	1/115	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8V19FD	GO:0016209	1/115	antioxidant activity	molecular_function	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
EOG8V19FD	GO:0005737	1/115	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZKN28	GO:0008168	24/162	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8ZKN28	GO:0030798	11/162	trans-aconitate 2-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972]
EOG8ZKN22	GO:0008603	25/93	cAMP-dependent protein kinase regulator activity	molecular_function	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]
EOG8ZKN22	GO:0005952	25/93	cAMP-dependent protein kinase complex	cellular_component	"An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732]
EOG8ZKN22	GO:0016301	2/93	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8ZKN22	GO:0004715	2/93	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8ZKN22	GO:0019933	1/93	cAMP-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
EOG8ZKN22	GO:0045859	1/93	regulation of protein kinase activity	biological_process	"Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
EOG8ZKN22	GO:0007274	1/93	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8ZKN22	GO:0008355	1/93	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8ZKN22	GO:2000253	1/93	positive regulation of feeding behavior	biological_process	"Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol]
EOG8ZKN22	GO:0008103	1/93	oocyte microtubule cytoskeleton polarization	biological_process	"Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042]
EOG8ZKN22	GO:0045471	1/93	response to ethanol	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators]
EOG8ZKN22	GO:0004691	1/93	cAMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11]
EOG8ZKN22	GO:0007591	1/93	molting cycle, chitin-based cuticle	biological_process	"The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu]
EOG8ZKN22	GO:0007015	1/93	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8ZKN22	GO:0030552	1/93	cAMP binding	molecular_function	"Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai]
EOG8RZ1GB	GO:0008137	2/87	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8RZ1GB	GO:0003954	1/87	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG805VG7	GO:0005506	679/2000	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG805VG7	GO:0020037	679/2000	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG805VG7	GO:0016705	629/2000	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG805VG7	GO:0004497	607/2000	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG805VG7	GO:0070330	31/2000	aromatase activity	molecular_function	"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
EOG805VG7	GO:0005789	25/2000	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG805VG7	GO:0050591	15/2000	quinine 3-monooxygenase activity	molecular_function	"Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152]
EOG805VG7	GO:0004796	4/2000	thromboxane-A synthase activity	molecular_function	"Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17140]
EOG805VG7	GO:0031000	2/2000	response to caffeine	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah]
EOG805VG7	GO:0009055	2/2000	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG805VG7	GO:0016712	2/2000	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
EOG805VG7	GO:0017085	2/2000	response to insecticide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]
EOG805VG7	GO:0006697	1/2000	ecdysone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732]
EOG805VG7	GO:0050829	1/2000	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG805VG7	GO:0030178	1/2000	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG805VG7	GO:0017143	1/2000	insecticide metabolic process	biological_process	"The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai]
EOG805VG7	GO:0046701	1/2000	insecticide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai]
EOG805VG7	GO:0022416	1/2000	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG805VG7	GO:0042742	1/2000	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG805VG7	GO:0048252	1/2000	lauric acid metabolic process	biological_process	"The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [CHEBI:30805, GOC:jid]
EOG805VG7	GO:0016020	1/2000	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG805VG7	GO:1901563	1/2000	response to camptothecin	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie]
EOG805VG7	GO:0018685	1/2000	alkane 1-monooxygenase activity	molecular_function	"Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3]
EOG805VG7	GO:0033777	1/2000	lithocholate 6beta-hydroxylase activity	molecular_function	"Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.13.94, RHEA:18860]
EOG805VG7	GO:0002118	1/2000	aggressive behavior	biological_process	"A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd]
EOG805VG7	GO:0046683	1/2000	response to organophosphorus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544]
EOG805VG7	GO:0035220	1/2000	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG805VG7	GO:0048638	1/2000	regulation of developmental growth	biological_process	"Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators]
EOG805VG7	GO:0040040	1/2000	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG805VG7	GO:0046680	1/2000	response to DDT	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544]
EOG805VG7	GO:0046689	1/2000	response to mercury ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai]
EOG805VG5	GO:0006937	27/115	regulation of muscle contraction	biological_process	"Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators]
EOG805VG5	GO:0005861	27/115	troponin complex	cellular_component	"A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction." [ISBN:0815316194]
EOG805VG5	GO:0007005	1/115	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG805VG5	GO:0048644	1/115	muscle organ morphogenesis	biological_process	"The process in which the anatomical structures of muscle are generated and organized." [GOC:jid]
EOG805VG5	GO:0006874	1/115	cellular calcium ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah]
EOG805VG5	GO:0030239	1/115	myofibril assembly	biological_process	"Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]
EOG805VG5	GO:0005865	1/115	striated muscle thin filament	cellular_component	"Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194]
EOG805VG5	GO:0005509	1/115	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG805VG5	GO:0007498	1/115	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG805VG5	GO:0030240	1/115	skeletal muscle thin filament assembly	biological_process	"The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle]
EOG805VG5	GO:0045214	1/115	sarcomere organization	biological_process	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
EOG805VG5	GO:0046716	1/115	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG8V45QH	GO:0000166	25/90	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8V45QH	GO:0003676	24/90	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V45QH	GO:0005634	1/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8V45QH	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8V45QH	GO:0003723	1/90	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8V45QH	GO:0048025	1/90	negative regulation of mRNA splicing, via spliceosome	biological_process	"Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]
EOG8V45QH	GO:0071011	1/90	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8V45QH	GO:0019013	1/90	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8V45QH	GO:0016607	1/90	nuclear speck	cellular_component	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]
EOG8V45QH	GO:0007052	1/90	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8V45QH	GO:0000398	1/90	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8V45QH	GO:0071013	1/90	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8V45QH	GO:0005685	1/90	U1 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U1." [GOC:krc, GOC:mah]
EOG8V45QH	GO:0005681	1/90	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8V45QH	GO:0003729	1/90	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8V45QH	GO:0022008	1/90	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8V45QH	GO:0000381	1/90	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8V45QH	GO:0030529	1/90	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8V45QH	GO:0043484	1/90	regulation of RNA splicing	biological_process	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]
EOG8Z0DP5	GO:0019013	4/87	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8Z0DP5	GO:0030529	4/87	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8Z0DP5	GO:0007067	1/87	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8Z0DP5	GO:0007422	1/87	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8Z0DP5	GO:0007517	1/87	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8Z0DP5	GO:0071011	1/87	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8Z0DP5	GO:0045451	1/87	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8Z0DP5	GO:0048542	1/87	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG8Z0DP5	GO:0005681	1/87	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8Z0DP5	GO:0045495	1/87	pole plasm	cellular_component	"Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380]
EOG8Z0DP5	GO:0030182	1/87	neuron differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
EOG8Z0DP5	GO:0030532	1/87	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8Z0DP5	GO:0007417	1/87	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8Z0DP5	GO:0007052	1/87	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8Z0DP5	GO:0071013	1/87	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8Z0DP5	GO:0000398	1/87	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8Z0DP7	GO:0043565	25/95	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8Z0DP7	GO:0003700	25/95	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z0DP7	GO:0005634	24/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z0DP7	GO:0045747	1/95	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8Z0DP7	GO:0051726	1/95	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8Z0DP7	GO:0035218	1/95	leg disc development	biological_process	"Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
EOG8Z0DP7	GO:0045892	1/95	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Z0DP7	GO:0022416	1/95	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8Z0DP7	GO:0043234	1/95	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8Z0DP7	GO:0004000	1/95	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8Z0DP7	GO:0007480	1/95	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8Z0DP7	GO:0048800	1/95	antennal morphogenesis	biological_process	"The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid]
EOG8Z0DP7	GO:0007501	1/95	mesodermal cell fate specification	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
EOG8Z0DP7	GO:0003677	1/95	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Z0DP7	GO:0045893	1/95	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Z0DP7	GO:0035015	1/95	elongation of arista core	biological_process	"The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081]
EOG8577P4	GO:0008270	4/27	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8577P4	GO:0016491	3/27	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8577P4	GO:0003960	1/27	NADPH:quinone reductase activity	molecular_function	"Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5]
EOG8QC3MN	GO:0030246	46/187	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8QC3MN	GO:0006810	2/187	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8QC3MN	GO:0016021	2/187	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QC3MN	GO:0016020	1/187	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QC3MN	GO:0008233	1/187	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8J6V5G	GO:0004872	25/91	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8J6V5G	GO:0007275	25/91	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8J6V5G	GO:0016021	15/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J6V5G	GO:0016020	10/91	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8W9MHR	GO:0005524	3/11	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8W9MHR	GO:0017038	3/11	protein import	biological_process	"The targeting and directed movement of proteins into a cell or organelle.  Not all import involves an initial targeting event." [GOC:ai]
EOG8W9MHR	GO:0016020	3/11	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8W9MHR	GO:0006605	2/11	protein targeting	biological_process	"The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]
EOG8J6V5J	GO:0003677	2/65	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8J6V5J	GO:0005634	1/65	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8J6V5J	GO:0006355	1/65	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8J6V5J	GO:0007431	1/65	salivary gland development	biological_process	"The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044]
EOG8J6V5J	GO:0045944	1/65	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8J6V5J	GO:0003700	1/65	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8J6V5J	GO:0005700	1/65	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8J6V5R	GO:0003676	8/63	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8J6V5R	GO:0015074	7/63	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8J6V5R	GO:0005634	2/63	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PP0Z7	GO:0005578	22/82	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG8PP0Z7	GO:0005509	22/82	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8PP0Z7	GO:0007165	22/82	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8PP0Z7	GO:0005615	18/82	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8PP0Z7	GO:0007498	1/82	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8PP0Z7	GO:0008138	1/82	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG8PP0Z7	GO:0007419	1/82	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8PP0Z7	GO:0007155	1/82	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8PP0Z7	GO:0007443	1/82	Malpighian tubule morphogenesis	biological_process	"The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089]
EOG8PP0Z7	GO:0060438	1/82	trachea development	biological_process	"The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG8PP0Z7	GO:0061327	1/82	anterior Malpighian tubule development	biological_process	"The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG8PP0Z7	GO:0006470	1/82	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8PP0Z7	GO:0070278	1/82	extracellular matrix constituent secretion	biological_process	"The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah]
EOG8J6V5X	GO:0005351	26/88	sugar:proton symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]
EOG8J6V5X	GO:0016021	26/88	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J6V5X	GO:0000139	26/88	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8J6V5X	GO:0015780	24/88	nucleotide-sugar transport	biological_process	"The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]
EOG8J6V5X	GO:0005338	24/88	nucleotide-sugar transmembrane transporter activity	molecular_function	"Enables the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926]
EOG8J6V5X	GO:0005797	1/88	Golgi medial cisterna	cellular_component	"The middle Golgi cisterna (or cisternae)." [ISBN:0815316194]
EOG8J6V5X	GO:0072334	1/88	UDP-galactose transmembrane transport	biological_process	"The directed movement of UDP-galactose across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8J6V5X	GO:0005463	1/88	UDP-N-acetylgalactosamine transmembrane transporter activity	molecular_function	"Catalysis of the transfer of a N-acetylgalactosamine from one side of the membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8J6V5X	GO:0015757	1/88	galactose transport	biological_process	"The directed movement of galactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai]
EOG8J6V5X	GO:0015789	1/88	UDP-N-acetylgalactosamine transport	biological_process	"The directed movement of UDP-N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
EOG8J6V5X	GO:0005459	1/88	UDP-galactose transmembrane transporter activity	molecular_function	"Catalysis of the transfer of a UDP-galactose from one side of the membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8J6V5X	GO:0015785	1/88	UDP-galactose transport	biological_process	"The directed movement of UDP-galactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai]
EOG8DBWV4	GO:0046872	25/90	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8B5RKV	GO:0005524	25/87	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8B5RKV	GO:0004674	23/87	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8B5RKV	GO:0004683	2/87	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG8B5RKV	GO:0007155	1/87	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8B5RKV	GO:0004672	1/87	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8B5RKV	GO:0009651	1/87	response to salt stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]
EOG8B5RKV	GO:0046328	1/87	regulation of JNK cascade	biological_process	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8B5RKV	GO:0006468	1/87	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8B5RKV	GO:0008360	1/87	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8B5RKV	GO:0045793	1/87	positive regulation of cell size	biological_process	"Any process that increases cell size." [GOC:go_curators]
EOG8DBWV0	GO:0005856	25/104	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8DBWV0	GO:0019898	24/104	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8DBWV0	GO:0005737	24/104	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8DBWV0	GO:0008092	1/104	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8DBWV9	GO:0003896	24/88	DNA primase activity	molecular_function	"Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases." [GOC:mah, GOC:mcc, ISBN:0716720094, PMID:26184436]
EOG8DBWV9	GO:1990077	21/88	primosome complex	cellular_component	"Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms.  Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart." [GOC:bhm, GOC:mah, PMID:21856207]
EOG8DBWV9	GO:0022008	1/88	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8DBWV9	GO:0046872	1/88	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DBWV9	GO:0003887	1/88	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8DBWV9	GO:0006269	1/88	DNA replication, synthesis of RNA primer	biological_process	"The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis." [PMID:11395402]
EOG8DBWV9	GO:0005658	1/88	alpha DNA polymerase:primase complex	cellular_component	"A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402]
EOG8DBWV9	GO:0006260	1/88	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8B5RKG	GO:0000166	21/77	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8B5RKG	GO:0003723	20/77	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8B5RKG	GO:0046872	20/77	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8B5RKG	GO:0005634	20/77	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8B5RKG	GO:0003729	1/77	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8B5RKG	GO:0005681	1/77	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8B5RKG	GO:0042060	1/77	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8B5RKG	GO:0000398	1/77	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8DBWVQ	GO:0016021	21/71	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DBWVQ	GO:0015171	1/71	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8DBWVQ	GO:0003333	1/71	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG8B5RK3	GO:0004222	17/76	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8P8J1Q	GO:0016301	1/33	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8B5RK9	GO:0000166	24/84	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8B5RK9	GO:0003676	23/84	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8B5RK9	GO:0005515	1/84	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8B5RK9	GO:0045451	1/84	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8B5RK9	GO:0007315	1/84	pole plasm assembly	biological_process	"Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8B5RK9	GO:0008298	1/84	intracellular mRNA localization	biological_process	"Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai]
EOG8B5RK9	GO:0048477	1/84	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8B5RK9	GO:0008270	1/84	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8B5RK9	GO:0048134	1/84	germ-line cyst formation	biological_process	"Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920]
EOG8B5RK9	GO:0046011	1/84	regulation of oskar mRNA translation	biological_process	"Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512]
EOG8B5RK9	GO:0005737	1/84	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8B5RK9	GO:0046012	1/84	positive regulation of oskar mRNA translation	biological_process	"Any process that activates or increases the frequency, rate or extent of oskar mRNA translation." [GOC:go_curators]
EOG8B5RK9	GO:0007294	1/84	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8B5RK9	GO:0007309	1/84	oocyte axis specification	biological_process	"The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8B5RK9	GO:0007281	1/84	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8B5RK9	GO:0005622	1/84	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8B5RK9	GO:0007314	1/84	oocyte anterior/posterior axis specification	biological_process	"Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8B5RK9	GO:0006378	1/84	mRNA polyadenylation	biological_process	"The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]
EOG8B5RK9	GO:0045727	1/84	positive regulation of translation	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8B5RK9	GO:0000578	1/84	embryonic axis specification	biological_process	"The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb]
EOG8B5RK9	GO:0007310	1/84	oocyte dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8B5RK9	GO:0003729	1/84	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8RR90B	GO:0006412	25/88	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8RR90B	GO:0003735	25/88	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8RR90B	GO:0005840	24/88	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8RR90B	GO:0003682	1/88	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8RR90B	GO:0005811	1/88	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8RR90B	GO:0007005	1/88	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8RR90B	GO:0005762	1/88	mitochondrial large ribosomal subunit	cellular_component	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
EOG8RR90B	GO:0016049	1/88	cell growth	biological_process	"The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]
EOG8QVFV7	GO:0007229	4/28	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG8QVFV7	GO:0016021	3/28	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QVFV7	GO:0007155	3/28	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG81K1S7	GO:0003834	3/101	beta-carotene 15,15'-monooxygenase activity	molecular_function	"Catalysis of the reaction: beta-carotene + O(2) = 2 retinal." [EC:1.14.99.36, RHEA:10407]
EOG81K1S7	GO:0004497	2/101	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG81K1S7	GO:0007602	1/101	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG81K1S7	GO:0009110	1/101	vitamin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:go_curators, ISBN:0198506732]
EOG81K1S7	GO:0046872	1/101	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81K1S7	GO:0010436	1/101	carotenoid dioxygenase activity	molecular_function	"Catalysis of the oxidative cleavage of carotenoids." [PMID:16459333]
EOG81K1S7	GO:0016119	1/101	carotene metabolic process	biological_process	"The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids." [ISBN:0198547684]
EOG81K1S7	GO:0004744	1/101	retinal isomerase activity	molecular_function	"Catalysis of the reaction: all-trans-retinal = 11-cis-retinal." [RHEA:24127]
EOG81K1S7	GO:0035238	1/101	vitamin A biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals cannot synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids." [PMID:11158606]
EOG81K1S7	GO:0042574	1/101	retinal metabolic process	biological_process	"The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [CHEBI:15035, GOC:curators, ISBN:0198506732]
EOG81K1S7	GO:0016063	1/101	rhodopsin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
EOG81K1S7	GO:0042572	1/101	retinol metabolic process	biological_process	"The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]
EOG866Z25	GO:0000813	1/85	ESCRT I complex	cellular_component	"An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
EOG866Z25	GO:0032509	1/85	endosome transport via multivesicular body sorting pathway	biological_process	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]
EOG8PP0ZK	GO:0003676	10/66	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8PP0ZK	GO:0019428	1/66	allantoin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:go_curators]
EOG8WHC28	GO:0006260	19/86	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8WHC28	GO:0005634	18/86	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WHC28	GO:0032508	1/86	DNA duplex unwinding	biological_process	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]
EOG8WHC28	GO:0005871	1/86	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8WHC28	GO:0007018	1/86	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8WHC28	GO:0003777	1/86	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8WHC28	GO:0005874	1/86	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8WHC28	GO:0046331	1/86	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8WHC28	GO:0005524	1/86	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WHC28	GO:1900087	1/86	positive regulation of G1/S transition of mitotic cell cycle	biological_process	"Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]
EOG8WHC28	GO:0000811	1/86	GINS complex	cellular_component	"A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990]
EOG8WHC28	GO:0022008	1/86	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8J6V57	GO:0003723	25/105	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8J6V57	GO:0005634	24/105	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8J6V57	GO:0006397	21/105	mRNA processing	biological_process	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]
EOG8J6V57	GO:0006396	4/105	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8J6V57	GO:0005622	1/105	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8J6V57	GO:0000381	1/105	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG87H83S	GO:0005694	27/103	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG87H83S	GO:0005524	26/103	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87H83S	GO:0051276	26/103	chromosome organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG87H83S	GO:0006281	21/103	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG87H83S	GO:0005634	21/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87H83S	GO:0006310	21/103	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG87H83S	GO:0007052	1/103	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG87H83S	GO:0003677	1/103	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG87H83S	GO:0005737	1/103	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87H83S	GO:0016491	1/103	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG87H83S	GO:0000070	1/103	mitotic sister chromatid segregation	biological_process	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
EOG87H83S	GO:0000166	1/103	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG87H83S	GO:0000819	1/103	sister chromatid segregation	biological_process	"The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh]
EOG87H83S	GO:0000785	1/103	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG87H83S	GO:0007076	1/103	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG87H83S	GO:0007422	1/103	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG87H83S	GO:0007067	1/103	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG87H83S	GO:0000796	1/103	condensin complex	cellular_component	"A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
EOG8935Z2	GO:0000166	27/99	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8935Z2	GO:0003676	26/99	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8935Z2	GO:0071011	1/99	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8935Z2	GO:0048477	1/99	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8935Z2	GO:0043234	1/99	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8935Z2	GO:0005515	1/99	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8935Z2	GO:0005634	1/99	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8935Z2	GO:0003729	1/99	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8935Z2	GO:0001558	1/99	regulation of cell growth	biological_process	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8935Z2	GO:0000380	1/99	alternative mRNA splicing, via spliceosome	biological_process	"The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900]
EOG8935Z2	GO:0006376	1/99	mRNA splice site selection	biological_process	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]
EOG8935Z2	GO:0016491	1/99	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8935Z2	GO:0000381	1/99	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8935Z2	GO:0022008	1/99	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8935Z2	GO:0008266	1/99	poly(U) RNA binding	molecular_function	"Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule." [GOC:mah]
EOG8935Z2	GO:0007282	1/99	cystoblast division	biological_process	"Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells." [PMID:21452446]
EOG8935Z2	GO:0000398	1/99	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8935Z2	GO:0071013	1/99	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8935Z7	GO:0051258	63/183	protein polymerization	biological_process	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
EOG8935Z7	GO:0003924	63/183	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8935Z7	GO:0005874	63/183	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8935Z7	GO:0005525	63/183	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8935Z7	GO:0005200	63/183	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8935Z7	GO:0005737	62/183	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8935Z7	GO:0007017	61/183	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8935Z7	GO:0009987	3/183	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8935Z7	GO:0007052	2/183	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8935Z7	GO:0007094	2/183	mitotic spindle assembly checkpoint	biological_process	"A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190]
EOG8935Z7	GO:0005819	1/183	spindle	cellular_component	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
EOG8935Z7	GO:0000902	1/183	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8935Z7	GO:0000235	1/183	astral microtubule	cellular_component	"Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194]
EOG8935Z7	GO:0005813	1/183	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8935Z7	GO:0005524	1/183	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8935Z7	GO:0000281	1/183	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8935Z7	GO:0042626	1/183	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8935Z7	GO:0016021	1/183	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8935Z7	GO:0051298	1/183	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8935Z7	GO:0019730	1/183	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG8935Z7	GO:0017022	1/183	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8935Z7	GO:0005811	1/183	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8XWJF2	GO:0008299	22/108	isoprenoid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
EOG8XWJF2	GO:0005737	22/108	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XWJF2	GO:0005524	22/108	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8XWJF2	GO:0004496	22/108	mevalonate kinase activity	molecular_function	"Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+)." [EC:2.7.1.36, RHEA:17068]
EOG8Q5C4B	GO:0003677	19/328	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Q5C4B	GO:0000166	18/328	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8Q5C4B	GO:0008408	18/328	3'-5' exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]
EOG8Q5C4B	GO:0003887	18/328	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8Q5C4B	GO:0006298	6/328	mismatch repair	biological_process	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
EOG8Q5C4B	GO:0004519	6/328	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8Q5C4B	GO:0006353	3/328	DNA-templated transcription, termination	biological_process	"The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161]
EOG8Q5C4B	GO:0003676	2/328	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q5C4B	GO:0003964	1/328	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8Q5C4B	GO:0006355	1/328	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Q5C4B	GO:0003723	1/328	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8XWJF9	GO:0006412	26/79	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8XWJF9	GO:0003735	26/79	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8XWJF9	GO:0005840	25/79	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8XWJF9	GO:0005763	1/79	mitochondrial small ribosomal subunit	cellular_component	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
EOG8DV816	GO:0003676	2/32	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DV816	GO:0000166	2/32	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8DV815	GO:0018738	19/140	S-formylglutathione hydrolase activity	molecular_function	"Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+)." [EC:3.1.2.12, RHEA:14964]
EOG8DV815	GO:0046294	19/140	formaldehyde catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai]
EOG8DV815	GO:0052689	2/140	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG803081	GO:0003839	43/99	gamma-glutamylcyclotransferase activity	molecular_function	"Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [EC:2.3.2.4]
EOG803081	GO:0006750	43/99	glutathione biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, GOC:al, GOC:pde, ISBN:0198506732]
EOG803081	GO:0005576	1/99	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG803081	GO:0042381	1/99	hemolymph coagulation	biological_process	"Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949]
EOG81VNJJ	GO:0016021	20/74	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81VNJJ	GO:0004930	19/74	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG80306S	GO:0008270	1/116	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8T1M2R	GO:0003723	26/92	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8D2951	GO:0003677	20/68	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8D2951	GO:0003682	19/68	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8D2951	GO:0008270	6/68	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D2951	GO:0016573	1/68	histone acetylation	biological_process	"The modification of a histone by the addition of an acetyl group." [GOC:ai]
EOG8D2951	GO:0043967	1/68	histone H4 acetylation	biological_process	"The modification of histone H4 by the addition of an acetyl group." [GOC:jl]
EOG8D2951	GO:0000123	1/68	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG8D2951	GO:0006338	1/68	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG8D2951	GO:0004402	1/68	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8D2951	GO:0043966	1/68	histone H3 acetylation	biological_process	"The modification of histone H3 by the addition of an acetyl group." [GOC:jl]
EOG8DV81S	GO:0003676	6/1523	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DV81S	GO:0015074	4/1523	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8DV81S	GO:0003677	3/1523	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DV81S	GO:0008270	2/1523	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DV81S	GO:0003723	2/1523	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8DV81S	GO:0003964	2/1523	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8DV81S	GO:0005524	1/1523	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8DV81S	GO:0008234	1/1523	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8DV81S	GO:0004518	1/1523	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG803069	GO:0009311	24/66	oligosaccharide metabolic process	biological_process	"The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]
EOG803069	GO:0004573	24/66	mannosyl-oligosaccharide glucosidase activity	molecular_function	"Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106]
EOG8D295V	GO:0004852	32/94	uroporphyrinogen-III synthase activity	molecular_function	"Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III." [EC:4.2.1.75, RHEA:18968]
EOG8D295V	GO:0033014	32/94	tetrapyrrole biosynthetic process	biological_process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah]
EOG8935ZX	GO:0006071	5/37	glycerol metabolic process	biological_process	"The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]
EOG8935ZX	GO:0008889	5/37	glycerophosphodiester phosphodiesterase activity	molecular_function	"Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]
EOG8935ZX	GO:0006629	5/37	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8935ZZ	GO:0008234	5/251	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8935ZZ	GO:0015074	1/251	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8935ZZ	GO:0003964	1/251	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8935ZZ	GO:0003723	1/251	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8935ZZ	GO:0003676	1/251	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8935ZS	GO:0005634	8/42	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8935ZS	GO:0006260	8/42	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8VT8CH	GO:0004419	26/77	hydroxymethylglutaryl-CoA lyase activity	molecular_function	"Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA." [EC:4.1.3.4, RHEA:24407]
EOG8VT8CH	GO:0005875	1/77	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8VT8CJ	GO:0004222	24/78	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8NZX9F	GO:0022904	25/88	respiratory electron transport chain	biological_process	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]
EOG8NZX9F	GO:0005743	25/88	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8NZX9F	GO:0016651	22/88	oxidoreductase activity, acting on NAD(P)H	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8NZX9F	GO:0008137	3/88	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG80P6NW	GO:0016884	24/51	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	molecular_function	"Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532]
EOG80P6NW	GO:0051726	1/51	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8D55BH	GO:0004872	1/119	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8D55BH	GO:0016021	1/119	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D55BH	GO:0007411	1/119	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8D55BH	GO:0030424	1/119	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8D55BH	GO:0030426	1/119	growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194]
EOG8D55BH	GO:0031290	1/119	retinal ganglion cell axon guidance	biological_process	"The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs]
EOG8D55BH	GO:0005886	1/119	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8D55BH	GO:0072499	1/119	photoreceptor cell axon guidance	biological_process	"The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
EOG8Z91CV	GO:0005634	43/153	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z91CV	GO:0043565	43/153	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8Z91CV	GO:0003700	42/153	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z91CV	GO:0001077	1/153	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG8Z91CV	GO:0042052	1/153	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8Z91CV	GO:0045893	1/153	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Z91CV	GO:0042051	1/153	compound eye photoreceptor development	biological_process	"The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
EOG8Z91CV	GO:0045944	1/153	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8Z91CV	GO:0042463	1/153	ocellus photoreceptor cell development	biological_process	"Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus." [GOC:jl, ISBN:0192800981, PMID:11542766]
EOG8Z91CV	GO:0042803	1/153	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG82RGQJ	GO:0016021	26/83	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6ND	GO:0016021	230/726	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6ND	GO:0022891	177/726	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG80P6ND	GO:0022857	38/726	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG80P6ND	GO:0008643	18/726	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG80P6ND	GO:0005886	18/726	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80P6ND	GO:0015771	15/726	trehalose transport	biological_process	"The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai]
EOG80P6ND	GO:0015574	15/726	trehalose transmembrane transporter activity	molecular_function	"Enables the transfer of trehalose from one side of the membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
EOG80P6ND	GO:0032440	8/726	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG80P6ND	GO:0016020	2/726	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG80P6ND	GO:0046427	1/726	positive regulation of JAK-STAT cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG86MF06	GO:0016757	26/93	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG86MF06	GO:0006488	1/93	dolichol-linked oligosaccharide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309]
EOG86MF06	GO:0006486	1/93	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG86MF06	GO:0000009	1/93	alpha-1,6-mannosyltransferase activity	molecular_function	"Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage." [GOC:mcc, PMID:2644248]
EOG86MF06	GO:0005789	1/93	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG86MF06	GO:0052917	1/93	dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity	molecular_function	"Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [EC:2.4.1.260, RHEA:29538]
EOG86MF06	GO:0016021	1/93	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86MF06	GO:0005783	1/93	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG86MF06	GO:0097502	1/93	mannosylation	biological_process	"The covalent attachment of a mannose residue to a substrate molecule." [GOC:cjm]
EOG82RGQC	GO:0016849	1/24	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG82RGQC	GO:0009190	1/24	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG82RGQC	GO:0035556	1/24	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8D55BV	GO:0016787	51/385	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8D55BV	GO:0052689	4/385	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG8D55BV	GO:0008152	2/385	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8D55BV	GO:0005576	1/385	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8D55BV	GO:0008340	1/385	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8D55BV	GO:0005737	1/385	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8D55BV	GO:0005811	1/385	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8D55BV	GO:0007476	1/385	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8D55BV	GO:0060179	1/385	male mating behavior	biological_process	"The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb]
EOG8D55BV	GO:0003990	1/385	acetylcholinesterase activity	molecular_function	"Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
EOG8D55BV	GO:0019915	1/385	lipid storage	biological_process	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]
EOG8D55BV	GO:0046683	1/385	response to organophosphorus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544]
EOG86MF08	GO:0008270	34/105	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG86MF08	GO:0003676	30/105	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG86MF08	GO:0016874	3/105	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG86MF08	GO:0007095	1/105	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG86MF08	GO:0005652	1/105	nuclear lamina	cellular_component	"The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363]
EOG86MF08	GO:0003677	1/105	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86MF08	GO:0005737	1/105	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86MF08	GO:0005700	1/105	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG86MF08	GO:0045089	1/105	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG86MF08	GO:0035012	1/105	polytene chromosome, telomeric region	cellular_component	"The terminal region of a polytene chromosome." [GOC:bf]
EOG86MF08	GO:0022008	1/105	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG86MF08	GO:0005634	1/105	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86MF08	GO:0046426	1/105	negative regulation of JAK-STAT cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG86MF08	GO:0007446	1/105	imaginal disc growth	biological_process	"The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387]
EOG86MF08	GO:0046425	1/105	regulation of JAK-STAT cascade	biological_process	"Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf]
EOG86MF08	GO:0030097	1/105	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG86MF08	GO:0050829	1/105	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG86MF08	GO:0030261	1/105	chromosome condensation	biological_process	"The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG86MF08	GO:0048749	1/105	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG86MF08	GO:0051276	1/105	chromosome organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG86MF08	GO:0005654	1/105	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG86MF08	GO:0042176	1/105	regulation of protein catabolic process	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]
EOG8HDW7N	GO:0019898	52/195	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8HDW7N	GO:0005737	52/195	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HDW7N	GO:0005856	48/195	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8HDW7N	GO:0008285	26/195	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8HDW7N	GO:0005912	6/195	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8HDW7N	GO:0005886	6/195	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8HDW7N	GO:0045197	5/195	establishment or maintenance of epithelial cell apical/basal polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]
EOG8HDW7N	GO:0003779	5/195	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8HDW7N	GO:0005938	2/195	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8HDW7N	GO:0042048	2/195	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG8HDW7N	GO:0008092	2/195	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8HDW7N	GO:0005515	2/195	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8HDW7N	GO:0016324	1/195	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8HDW7N	GO:0002009	1/195	morphogenesis of an epithelium	biological_process	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
EOG8HDW7N	GO:0001745	1/195	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8HDW7N	GO:0001558	1/195	regulation of cell growth	biological_process	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8HDW7N	GO:0006351	1/195	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8HDW7N	GO:0000912	1/195	assembly of actomyosin apparatus involved in cytokinesis	biological_process	"The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:mtg_cell_cycle]
EOG8HDW7N	GO:0019094	1/195	pole plasm mRNA localization	biological_process	"Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
EOG8HDW7N	GO:0072499	1/195	photoreceptor cell axon guidance	biological_process	"The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
EOG8HDW7N	GO:0006355	1/195	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8HDW7N	GO:0051258	1/195	protein polymerization	biological_process	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
EOG8HDW7N	GO:0032154	1/195	cleavage furrow	cellular_component	"In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409]
EOG8HDW7N	GO:0003924	1/195	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8HDW7N	GO:0007091	1/195	metaphase/anaphase transition of mitotic cell cycle	biological_process	"The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mtg_cell_cycle, PMID:10465783]
EOG8HDW7N	GO:0045313	1/195	rhabdomere membrane biogenesis	biological_process	"A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane." [GOC:jl]
EOG8HDW7N	GO:0045433	1/195	male courtship behavior, veined wing generated song production	biological_process	"The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
EOG8HDW7N	GO:0000132	1/195	establishment of mitotic spindle orientation	biological_process	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
EOG8HDW7N	GO:0016336	1/195	establishment or maintenance of polarity of larval imaginal disc epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium." [GOC:jl, GOC:mah]
EOG8HDW7N	GO:0007476	1/195	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8HDW7N	GO:0036375	1/195	Kibra-Ex-Mer complex	cellular_component	"An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2." [PMID:20159598]
EOG8HDW7N	GO:0016787	1/195	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8HDW7N	GO:0007283	1/195	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8HDW7N	GO:0032956	1/195	regulation of actin cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]
EOG8HDW7N	GO:1990023	1/195	mitotic spindle midzone	cellular_component	"The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner." [GOC:mtg_cell_cycle, GOC:vw]
EOG8HDW7N	GO:0007017	1/195	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8HDW7N	GO:0072659	1/195	protein localization to plasma membrane	biological_process	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]
EOG8HDW7N	GO:0008104	1/195	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8HDW7N	GO:0051653	1/195	spindle localization	biological_process	"Any process in which is the spindle is transported to, and/or maintained in, a specific location." [GOC:ai]
EOG8HDW7N	GO:0001934	1/195	positive regulation of protein phosphorylation	biological_process	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
EOG8HDW7N	GO:0035329	1/195	hippo signaling	biological_process	"The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1." [PMID:17318211, PMID:18328423]
EOG8HDW7N	GO:0046669	1/195	regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG8HDW7N	GO:0045595	1/195	regulation of cell differentiation	biological_process	"Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]
EOG8HDW7N	GO:0032456	1/195	endocytic recycling	biological_process	"The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635]
EOG8HDW7N	GO:0035003	1/195	subapical complex	cellular_component	"The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938]
EOG8HDW7N	GO:0030029	1/195	actin filament-based process	biological_process	"Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah]
EOG8HDW7N	GO:0016020	1/195	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HDW7N	GO:0042802	1/195	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG8HDW7N	GO:0060253	1/195	negative regulation of glial cell proliferation	biological_process	"Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb]
EOG8HDW7N	GO:0006897	1/195	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8HDW7N	GO:0005525	1/195	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8HDW7N	GO:0007318	1/195	pole plasm protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
EOG8HDW7N	GO:0042462	1/195	eye photoreceptor cell development	biological_process	"Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981]
EOG8HDW7N	GO:0009966	1/195	regulation of signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]
EOG8HDW7N	GO:0007267	1/195	cell-cell signaling	biological_process	"Any process that mediates the transfer of information from one cell to another." [GOC:mah]
EOG8HDW7N	GO:0009952	1/195	anterior/posterior pattern specification	biological_process	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8HDW7N	GO:0007052	1/195	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8HDW7N	GO:0046621	1/195	negative regulation of organ growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
EOG8HDW7N	GO:0008101	1/195	decapentaplegic signaling pathway	biological_process	"A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:sart, PMID:17428827]
EOG8HDW7N	GO:0007050	1/195	cell cycle arrest	biological_process	"A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]
EOG8HDW7N	GO:0042052	1/195	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8HDW7N	GO:0000902	1/195	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8HDW7N	GO:0007112	1/195	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG8HDW7N	GO:0042327	1/195	positive regulation of phosphorylation	biological_process	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]
EOG8HDW7N	GO:0009798	1/195	axis specification	biological_process	"The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete]
EOG8HDW7N	GO:0007368	1/195	determination of left/right symmetry	biological_process	"The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]
EOG8HDW7N	GO:0005634	1/195	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HDW7N	GO:0007315	1/195	pole plasm assembly	biological_process	"Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8HDW7N	GO:0007010	1/195	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8HDW7N	GO:0033109	1/195	cortical actin cytoskeleton stabilization	biological_process	"The process in which the assembly and arrangement of cytoskeletal structures in the actin cortex with respect to the plasma membrane is maintained." [GOC:mah, GOC:pf]
EOG8HDW7N	GO:0042127	1/195	regulation of cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
EOG8HDW7N	GO:0005874	1/195	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8HDW7N	GO:0007314	1/195	oocyte anterior/posterior axis specification	biological_process	"Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8HDW7N	GO:0007291	1/195	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8HDW7N	GO:0016006	1/195	Nebenkern	cellular_component	"A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma]
EOG8HDW7N	GO:0035088	1/195	establishment or maintenance of apical/basal cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483]
EOG8HDW7N	GO:0001751	1/195	compound eye photoreceptor cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
EOG8HDW7N	GO:0005200	1/195	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8HDW7N	GO:0030036	1/195	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8HDW7N	GO:0005546	1/195	phosphatidylinositol-4,5-bisphosphate binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]
EOG8HDW7N	GO:0005524	1/195	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8HDW7N	GO:0016057	1/195	regulation of membrane potential in photoreceptor cell	biological_process	"Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb]
EOG8HDW7N	GO:0035330	1/195	regulation of hippo signaling	biological_process	"Any process that modulates the frequency, rate or extent of hippo signaling." [GOC:bf]
EOG8HDW7N	GO:0042981	1/195	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG80VZ3W	GO:0005524	75/265	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG80VZ3W	GO:0008026	71/265	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG80VZ3W	GO:0003676	52/265	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80VZ3W	GO:0003723	23/265	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG80VZ3W	GO:0004386	4/265	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG80VZ3W	GO:0022008	3/265	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG80VZ3W	GO:0006200	2/265	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG80VZ3W	GO:0000398	2/265	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG80VZ3W	GO:0071013	2/265	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG80VZ3W	GO:0005681	2/265	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG80VZ3W	GO:0071011	2/265	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG80VZ3W	GO:0004004	2/265	ATP-dependent RNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]
EOG80VZ3W	GO:0008152	1/265	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG80VZ3W	GO:0016779	1/265	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG80VZ3W	GO:0000381	1/265	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG80VZ3W	GO:0007286	1/265	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG80VZ3W	GO:0005634	1/265	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80VZ3W	GO:0016021	1/265	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80VZ3W	GO:0004654	1/265	polyribonucleotide nucleotidyltransferase activity	molecular_function	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.8]
EOG80VZ3W	GO:0006810	1/265	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG80VZ3W	GO:0055085	1/265	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8B8MV7	GO:0003743	25/83	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8B8MV7	GO:0046872	1/83	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8B8MV7	GO:0006413	1/83	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG8B8MV7	GO:0016199	1/83	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG8B8MV7	GO:0005850	1/83	eukaryotic translation initiation factor 2 complex	cellular_component	"Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940]
EOG8B8MV7	GO:0005875	1/83	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8B8MV7	GO:0007052	1/83	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8B8MV7	GO:0000022	1/83	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8B8MV7	GO:0005829	1/83	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8B8MV6	GO:0043565	9/45	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8B8MV6	GO:0003700	9/45	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8B8MV6	GO:0005634	8/45	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8B8MV6	GO:0006351	8/45	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8MWBQ0	GO:0006511	3/21	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG818F46	GO:0008270	1/173	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG818F46	GO:0003682	1/173	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG818F46	GO:0003676	1/173	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HB109	GO:0005634	3/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HB109	GO:0051028	3/90	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8HB109	GO:0004386	1/90	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8HB109	GO:0005524	1/90	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8HB109	GO:0016887	1/90	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8HB109	GO:0005875	1/90	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8HB109	GO:0004519	1/90	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG818F42	GO:0008236	25/69	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG818F42	GO:0016021	18/69	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG818F42	GO:0016020	7/69	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG88973M	GO:0005874	1/80	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG88973M	GO:0005525	1/80	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG88973M	GO:0004930	1/80	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG88973M	GO:0007017	1/80	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG88973M	GO:0016020	1/80	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8H74S9	GO:0016020	26/100	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8H74S9	GO:0008654	24/100	phospholipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8H74S9	GO:0016780	23/100	phosphotransferase activity, for other substituted phosphate groups	molecular_function	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]
EOG8H74S9	GO:0004142	2/100	diacylglycerol cholinephosphotransferase activity	molecular_function	"Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2]
EOG8H74S9	GO:0004307	1/100	ethanolaminephosphotransferase activity	molecular_function	"Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [EC:2.7.8.1]
EOG8H74S9	GO:0016740	1/100	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG818F4D	GO:0006412	26/89	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG818F4D	GO:0003735	26/89	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG818F4D	GO:0005840	26/89	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG818F4D	GO:0000022	1/89	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG818F4D	GO:0051298	1/89	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG818F4D	GO:0007052	1/89	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG88973C	GO:0008270	24/187	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG88973C	GO:0003676	23/187	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88973C	GO:0005634	2/187	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88973C	GO:0004190	1/187	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG88973C	GO:0016891	1/187	endoribonuclease activity, producing 5'-phosphomonoesters	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
EOG88973C	GO:0003700	1/187	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG88973C	GO:0003677	1/187	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8HB10T	GO:0016709	25/82	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
EOG8HB10T	GO:0006744	23/82	ubiquinone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]
EOG8HB10T	GO:0050660	23/82	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8HB10T	GO:0005794	1/82	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8B8MX0	GO:0003899	22/57	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8B8MX0	GO:0003677	22/57	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8B8MX0	GO:0006351	21/57	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8B8MX0	GO:0006366	1/57	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8B8MX0	GO:0005736	1/57	DNA-directed RNA polymerase I complex	cellular_component	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8B8MX0	GO:0006383	1/57	transcription from RNA polymerase III promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH]
EOG8B8MX0	GO:0005666	1/57	DNA-directed RNA polymerase III complex	cellular_component	"RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8B8MX0	GO:0005665	1/57	DNA-directed RNA polymerase II, core complex	cellular_component	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8B8MX0	GO:0006360	1/57	transcription from RNA polymerase I promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
EOG86MF0F	GO:0046872	23/89	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QC3M2	GO:0005524	26/95	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QC3M2	GO:0006281	26/95	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8QC3M2	GO:0003684	26/95	damaged DNA binding	molecular_function	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
EOG8QC3M2	GO:0008094	26/95	DNA-dependent ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl]
EOG8QC3M2	GO:0016740	1/95	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8QC3M2	GO:0010569	1/95	regulation of double-strand break repair via homologous recombination	biological_process	"Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]
EOG8QC3M2	GO:0009994	1/95	oocyte differentiation	biological_process	"The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu]
EOG8QC3M2	GO:0005515	1/95	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QC3M2	GO:0005634	1/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8QC3M2	GO:0007143	1/95	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8QC3M2	GO:0008298	1/95	intracellular mRNA localization	biological_process	"Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai]
EOG8QC3M2	GO:0048477	1/95	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8QC3M2	GO:0009949	1/95	polarity specification of anterior/posterior axis	biological_process	"Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators]
EOG8QC3M2	GO:0030717	1/95	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG8QC3M2	GO:0007294	1/95	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8QC3M2	GO:0045003	1/95	double-strand break repair via synthesis-dependent strand annealing	biological_process	"SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855]
EOG8QC3M2	GO:0009951	1/95	polarity specification of dorsal/ventral axis	biological_process	"Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators]
EOG86MF0P	GO:0006950	1/31	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8B2WBP	GO:0016592	1/75	mediator complex	cellular_component	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
EOG8B2WBP	GO:0001104	1/75	RNA polymerase II transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8NKFB8	GO:0004089	104/367	carbonate dehydratase activity	molecular_function	"Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1]
EOG8NKFB8	GO:0006730	100/367	one-carbon metabolic process	biological_process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
EOG8NKFB8	GO:0008270	99/367	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NKFB8	GO:0031233	1/367	intrinsic component of external side of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah]
EOG876NDN	GO:0046872	12/72	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG876NDN	GO:0005525	7/72	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG876NDN	GO:0003924	7/72	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG876NDN	GO:0005622	2/72	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG876NDN	GO:0008270	2/72	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8F7R0C	GO:0005525	27/89	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8F7R0C	GO:0003924	26/89	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8F7R0C	GO:0003747	6/89	translation release factor activity	molecular_function	"Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]
EOG8F7R0C	GO:0004781	2/89	sulfate adenylyltransferase (ATP) activity	molecular_function	"Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4]
EOG8F7R0C	GO:0003746	1/89	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG8F7R0C	GO:0005829	1/89	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8F7R0C	GO:0008079	1/89	translation termination factor activity	molecular_function	"Functions in the termination of translation." [GOC:ma]
EOG8F7R0C	GO:0006184	1/89	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8F7R0C	GO:0006415	1/89	translational termination	biological_process	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]
EOG876NDC	GO:0016787	24/115	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG876NDC	GO:0052689	3/115	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG876NDC	GO:0003990	2/115	acetylcholinesterase activity	molecular_function	"Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
EOG876NDC	GO:0004104	1/115	cholinesterase activity	molecular_function	"Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8]
EOG8NKFB5	GO:0005509	25/70	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8NKFB5	GO:0016787	2/70	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8NKFB5	GO:0004198	1/70	calcium-dependent cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]
EOG8NKFB5	GO:0006508	1/70	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8NKFB5	GO:0005737	1/70	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8NKFB5	GO:0046330	1/70	positive regulation of JNK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG89GNZ3	GO:0005890	79/270	sodium:potassium-exchanging ATPase complex	cellular_component	"Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732]
EOG89GNZ3	GO:0006813	78/270	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG89GNZ3	GO:0006814	76/270	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG89GNZ3	GO:0005886	3/270	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG89GNZ3	GO:0007605	2/270	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG89GNZ3	GO:0035725	2/270	sodium ion transmembrane transport	biological_process	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
EOG89GNZ3	GO:0006812	2/270	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG89GNZ3	GO:0035158	1/270	regulation of tube diameter, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584]
EOG89GNZ3	GO:0060857	1/270	establishment of glial blood-brain barrier	biological_process	"Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
EOG89GNZ3	GO:0005391	1/270	sodium:potassium-exchanging ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9]
EOG89GNZ3	GO:0035159	1/270	regulation of tube length, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
EOG89GNZ3	GO:0007424	1/270	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG89GNZ3	GO:0010996	1/270	response to auditory stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus." [GOC:BHF, GOC:dph, GOC:sl, GOC:tb]
EOG89GNZ3	GO:0005515	1/270	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG89GNZ3	GO:0035151	1/270	regulation of tube size, open tracheal system	biological_process	"Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]
EOG89GNZ3	GO:0019991	1/270	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG89GNZ3	GO:0005918	1/270	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG89GNZ3	GO:0061343	1/270	cell adhesion involved in heart morphogenesis	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
EOG89GNZ1	GO:0008270	2/37	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84N18H	GO:0005737	26/91	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84N18H	GO:0005634	26/91	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84N18H	GO:0045892	26/91	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG84N18H	GO:0046552	1/91	photoreceptor cell fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
EOG84N18H	GO:0046843	1/91	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG84N18H	GO:0045466	1/91	R7 cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339]
EOG84N18H	GO:0007286	1/91	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG84N18H	GO:0046331	1/91	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG84N18H	GO:0007476	1/91	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG84N18H	GO:0001964	1/91	startle response	biological_process	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
EOG84N18H	GO:0008586	1/91	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG84N18H	GO:0007391	1/91	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG84N18H	GO:0007541	1/91	sex determination, primary response to X:A ratio	biological_process	"The developmental process in which an organism interprets its X to autosomal chromosomal complement." [GOC:isa_complete]
EOG84N18H	GO:0003677	1/91	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84N18H	GO:0008283	1/91	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG84N18H	GO:0042675	1/91	compound eye cone cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu]
EOG84N18H	GO:0046982	1/91	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG84N18H	GO:0007422	1/91	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG84N18H	GO:0007460	1/91	R8 cell fate commitment	biological_process	"The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883]
EOG84N18H	GO:0043392	1/91	negative regulation of DNA binding	biological_process	"Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
EOG84N18H	GO:0007494	1/91	midgut development	biological_process	"The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
EOG84N18H	GO:0002121	1/91	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG84N18H	GO:0031987	1/91	locomotion involved in locomotory behavior	biological_process	"Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
EOG84N18H	GO:0048854	1/91	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG84N18H	GO:0007530	1/91	sex determination	biological_process	"Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732]
EOG84N18H	GO:0007458	1/91	progression of morphogenetic furrow involved in compound eye morphogenesis	biological_process	"The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883]
EOG84N18H	GO:0001191	1/91	transcriptional repressor activity, RNA polymerase II transcription factor binding	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:9811836]
EOG84N18H	GO:0030381	1/91	chorion-containing eggshell pattern formation	biological_process	"The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu]
EOG84N18H	GO:0008258	1/91	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG84N18H	GO:0000122	1/91	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG84N18H	GO:0048056	1/91	R3/R4 cell differentiation	biological_process	"The process in which relatively unspecialized cells acquire the specialized features of R3 and R4 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid]
EOG8SFCKX	GO:0005524	50/173	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SFCKX	GO:0006438	50/173	valyl-tRNA aminoacylation	biological_process	"The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8SFCKX	GO:0004832	50/173	valine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.9, RHEA:10707]
EOG8SFCKX	GO:0002161	49/173	aminoacyl-tRNA editing activity	molecular_function	"The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889]
EOG8SFCKX	GO:0005737	12/173	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SFCKX	GO:0022008	1/173	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8SFCKX	GO:0003676	1/173	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SFCKX	GO:0004818	1/173	glutamate-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17]
EOG8VHNP9	GO:0005840	4/86	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8VHNP9	GO:0005762	2/86	mitochondrial large ribosomal subunit	cellular_component	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
EOG8VHNP9	GO:0006412	2/86	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8VHNP9	GO:0003735	2/86	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG86T5GC	GO:0000166	23/67	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG86T5GC	GO:0003676	22/67	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG86T5GC	GO:0019013	2/67	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG86T5GC	GO:0030529	2/67	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG86T5GC	GO:0005515	1/67	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG86T5GC	GO:0007311	1/67	maternal specification of dorsal/ventral axis, oocyte, germ-line encoded	biological_process	"Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG86T5GC	GO:0045451	1/67	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG86T5GC	GO:0043234	1/67	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG86T5GC	GO:0051276	1/67	chromosome organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG86T5GC	GO:0008270	1/67	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG86T5GC	GO:0042060	1/67	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG86T5GC	GO:0006417	1/67	regulation of translation	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG86T5GC	GO:0060810	1/67	intracellular mRNA localization involved in pattern specification process	biological_process	"Any process in which mRNA is transported to, or maintained in, a specific location within an oocyte that results in a pattern being established in the embryo." [GOC:dph, GOC:sdb_2009, GOC:tb]
EOG86T5GC	GO:0005622	1/67	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG86T5GC	GO:0046427	1/67	positive regulation of JAK-STAT cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG86T5GC	GO:0003729	1/67	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8GXJ2W	GO:0007165	18/74	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8GXJ2W	GO:0045089	1/74	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8GXJ2W	GO:0005622	1/74	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8GXJ2W	GO:0019730	1/74	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG8GXJ2W	GO:0006959	1/74	humoral immune response	biological_process	"An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]
EOG8GXJ2W	GO:0006963	1/74	positive regulation of antibacterial peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475]
EOG8GXJ2W	GO:0070513	1/74	death domain binding	molecular_function	"Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531]
EOG8GXJ2W	GO:0019731	1/74	antibacterial humoral response	biological_process	"An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8GXJ2W	GO:0006964	1/74	positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
EOG8GXJ2W	GO:0061057	1/74	peptidoglycan recognition protein signaling pathway	biological_process	"A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280]
EOG8GXJ2W	GO:0005515	1/74	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8GXJ2W	GO:0042742	1/74	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8GXJ2W	GO:0002230	1/74	positive regulation of defense response to virus by host	biological_process	"Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
EOG8GXJ2W	GO:0050829	1/74	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GXJ2W	GO:0045087	1/74	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8GXJ2W	GO:0006952	1/74	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8GXJ2W	GO:0009617	1/74	response to bacterium	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]
EOG8GXJ2W	GO:0006955	1/74	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8GXJ2W	GO:0035556	1/74	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8GXJ2W	GO:0007399	1/74	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG89GNZS	GO:0000266	25/84	mitochondrial fission	biological_process	"The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]
EOG89GNZS	GO:0090141	1/84	positive regulation of mitochondrial fission	biological_process	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG89GNZS	GO:0007005	1/84	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG89S8QM	GO:0003677	1/25	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DFS46	GO:0008236	25/62	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8DFS46	GO:0016020	24/62	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8DFS46	GO:0016021	1/62	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84N182	GO:0008796	19/86	bis(5'-nucleosyl)-tetraphosphatase activity	molecular_function	"Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai]
EOG84N182	GO:0004081	2/86	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	molecular_function	"Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [EC:3.6.1.17, PMID:4955726]
EOG8GXJ2M	GO:0050829	1/83	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GXJ2M	GO:0016905	1/83	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG8JQ6HK	GO:0003676	1/29	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG876ND1	GO:0020037	2/18	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG876ND1	GO:0006979	2/18	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG876ND1	GO:0005509	2/18	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG876ND1	GO:0004601	2/18	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG876ND1	GO:0016021	1/18	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZKN39	GO:0003723	31/120	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8ZKN39	GO:0030529	5/120	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8ZKN39	GO:0019013	4/120	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8ZKN39	GO:0007446	1/120	imaginal disc growth	biological_process	"The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387]
EOG8ZKN39	GO:0035107	1/120	appendage morphogenesis	biological_process	"The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]
EOG8ZKN39	GO:0005737	1/120	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZKN39	GO:0008134	1/120	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8ZKN39	GO:0008283	1/120	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8ZKN39	GO:0005634	1/120	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZKN39	GO:0003729	1/120	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8ZKN39	GO:0000381	1/120	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8ZKN39	GO:0000785	1/120	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG8ZKN39	GO:0045165	1/120	cell fate commitment	biological_process	"The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
EOG8ZKN39	GO:0035062	1/120	omega speckle	cellular_component	"A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439]
EOG8NW21S	GO:0071011	1/82	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8NW21S	GO:0000398	1/82	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8NW21S	GO:0071013	1/82	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8DBWWC	GO:0001682	1/63	tRNA 5'-leader removal	biological_process	"Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395]
EOG8DBWWC	GO:0004526	1/63	ribonuclease P activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5]
EOG8DBWWM	GO:0006729	25/79	tetrahydrobiopterin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, GOC:go_curators, ISBN:0198506732]
EOG8DBWWM	GO:0008124	25/79	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	molecular_function	"Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O." [EC:4.2.1.96, RHEA:11923]
EOG8P8J0B	GO:0003899	28/77	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8P8J0B	GO:0003677	28/77	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8P8J0B	GO:0006351	27/77	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8P8J0B	GO:0022008	1/77	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8P8J0B	GO:0006383	1/77	transcription from RNA polymerase III promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH]
EOG8P8J0B	GO:0005666	1/77	DNA-directed RNA polymerase III complex	cellular_component	"RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8X0Q69	GO:0008859	2/95	exoribonuclease II activity	molecular_function	"Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684]
EOG8X0Q69	GO:0022008	1/95	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8X0Q69	GO:0071027	1/95	nuclear RNA surveillance	biological_process	"The set of processes involved in identifying and degrading defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]
EOG8X0Q69	GO:0010468	1/95	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8X0Q69	GO:0005634	1/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X0Q69	GO:0000176	1/95	nuclear exosome (RNase complex)	cellular_component	"Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]
EOG8X0Q69	GO:0005652	1/95	nuclear lamina	cellular_component	"The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363]
EOG8FTZG4	GO:0003677	23/88	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FTZG4	GO:0003682	21/88	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8FTZG4	GO:0005634	1/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8577Q2	GO:0016272	24/76	prefoldin complex	cellular_component	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]
EOG8577Q2	GO:0006457	24/76	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8TMTHF	GO:0003676	194/895	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8TMTHF	GO:0003677	58/895	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TMTHF	GO:0004519	19/895	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8TMTHF	GO:0003964	19/895	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8TMTHF	GO:0003723	5/895	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8TMTHF	GO:0015074	3/895	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8TMTHF	GO:0005524	2/895	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8TMTHF	GO:0005525	1/895	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8TMTHF	GO:0006313	1/895	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG8TMTHF	GO:0004736	1/895	pyruvate carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847]
EOG8TMTHF	GO:0006094	1/895	gluconeogenesis	biological_process	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]
EOG8TMTHF	GO:0046872	1/895	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TMTHF	GO:0004075	1/895	biotin carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]
EOG8TMTHF	GO:0004674	1/895	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8TMTHF	GO:0004252	1/895	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8TMTHF	GO:0008270	1/895	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TMTHF	GO:0005634	1/895	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TMTHF	GO:0003924	1/895	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8TMTHF	GO:0016021	1/895	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TMTHF	GO:0004803	1/895	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG8BS00V	GO:0003964	1/142	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8BS00V	GO:0003723	1/142	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8FTZGW	GO:0005634	3/133	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FTZGW	GO:0016925	2/133	protein sumoylation	biological_process	"The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250]
EOG8FTZGW	GO:0055088	1/133	lipid homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]
EOG8FTZGW	GO:0043406	1/133	positive regulation of MAP kinase activity	biological_process	"Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]
EOG8FTZGW	GO:0006909	1/133	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8FTZGW	GO:0035073	1/133	pupariation	biological_process	"The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
EOG8FTZGW	GO:0005515	1/133	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FTZGW	GO:0006099	1/133	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8FTZGW	GO:0035186	1/133	syncytial blastoderm mitotic cell cycle	biological_process	"Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238]
EOG8FTZGW	GO:0000278	1/133	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8FTZGW	GO:0071560	1/133	cellular response to transforming growth factor beta stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575]
EOG8FTZGW	GO:0021952	1/133	central nervous system projection neuron axonogenesis	biological_process	"Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8FTZGW	GO:0046579	1/133	positive regulation of Ras protein signal transduction	biological_process	"Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
EOG8FTZGW	GO:0060997	1/133	dendritic spine morphogenesis	biological_process	"The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
EOG8FTZGW	GO:0030496	1/133	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG8FTZGW	GO:0000780	1/133	condensed nuclear chromosome, centromeric region	cellular_component	"The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
EOG8FTZGW	GO:0005730	1/133	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8FTZGW	GO:0006464	1/133	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG8FTZGW	GO:0006606	1/133	protein import into nucleus	biological_process	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]
EOG8FTZGW	GO:0000940	1/133	condensed chromosome outer kinetochore	cellular_component	"The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983]
EOG8FTZGW	GO:0016926	1/133	protein desumoylation	biological_process	"The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250]
EOG8FTZGW	GO:0007052	1/133	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8FTZGW	GO:0000794	1/133	condensed nuclear chromosome	cellular_component	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh]
EOG8FTZGW	GO:0046843	1/133	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8WWV1R	GO:0003676	182/2316	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WWV1R	GO:0008270	149/2316	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WWV1R	GO:0003677	110/2316	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8WWV1R	GO:0005634	107/2316	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WWV1R	GO:0015074	83/2316	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8WWV1R	GO:0003964	8/2316	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8WWV1R	GO:0003723	4/2316	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8WWV1R	GO:0004519	4/2316	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8WWV1R	GO:0046872	2/2316	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WWV1R	GO:0004190	1/2316	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8WWV1R	GO:0005524	1/2316	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WWV1R	GO:0008762	1/2316	UDP-N-acetylmuramate dehydrogenase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158]
EOG8WWV1R	GO:0006351	1/2316	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8WWV1R	GO:0050660	1/2316	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8WWV1R	GO:0016043	1/2316	cellular component organization	biological_process	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]
EOG8WWV1R	GO:0016787	1/2316	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8WWV1R	GO:0016491	1/2316	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8NW20H	GO:0000077	25/87	DNA damage checkpoint	biological_process	"A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle]
EOG8NW20H	GO:0006281	25/87	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8NW20H	GO:0030896	25/87	checkpoint clamp complex	cellular_component	"Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]
EOG8NW20H	GO:0008853	2/87	exodeoxyribonuclease III activity	molecular_function	"Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.2]
EOG8NW20H	GO:0005515	1/87	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8NW20H	GO:0005634	1/87	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NW20H	GO:0031965	1/87	nuclear membrane	cellular_component	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
EOG89W4WC	GO:0005737	24/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG89W4WC	GO:0061024	1/86	membrane organization	biological_process	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]
EOG89W4WC	GO:0016020	1/86	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG89W4WC	GO:0007296	1/86	vitellogenesis	biological_process	"The production of yolk. Yolk is a mixture of materials used for embryonic nutrition." [GOC:dph, ISBN:0879694238]
EOG89W4WC	GO:0030100	1/86	regulation of endocytosis	biological_process	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]
EOG8DBWW2	GO:0003676	1/11	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BP3V5	GO:0008270	2/7	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BP3V5	GO:0016740	1/7	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8ZKN3S	GO:0005739	22/104	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8ZKN3S	GO:0008137	22/104	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8ZKN3S	GO:0046872	10/104	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZKN3S	GO:0005525	1/104	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG89W4WM	GO:0008157	1/112	protein phosphatase 1 binding	molecular_function	"Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl]
EOG80306V	GO:0008270	329/890	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80306V	GO:0004181	329/890	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG80306V	GO:0005319	8/890	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG80306V	GO:0005615	3/890	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG80306V	GO:0007586	1/890	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG80306V	GO:0022008	1/890	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG80306V	GO:0031982	1/890	vesicle	cellular_component	"Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz]
EOG80306V	GO:0004180	1/890	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG80306V	GO:0005515	1/890	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG80306V	GO:0005576	1/890	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG80306V	GO:0016021	1/890	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80306V	GO:0004930	1/890	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8PG8HT	GO:0006412	20/68	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8PG8HT	GO:0003735	20/68	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8PG8HT	GO:0005840	20/68	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8PG8HS	GO:0030414	1/14	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8PG8HS	GO:0008233	1/14	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8XSP3N	GO:0008061	250/966	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8XSP3N	GO:0005576	250/966	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8XSP3N	GO:0006030	246/966	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8XSP3N	GO:0004252	27/966	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8XSP3N	GO:0005044	26/966	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8XSP3N	GO:0016020	24/966	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XSP3N	GO:0006032	4/966	chitin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8XSP3N	GO:0005975	4/966	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8XSP3N	GO:0004568	4/966	chitinase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
EOG8XSP3N	GO:0006955	2/966	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8XSP3N	GO:0030247	2/966	polysaccharide binding	molecular_function	"Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah]
EOG8XSP3N	GO:0030246	2/966	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8XSP3N	GO:0006508	1/966	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8XSP3N	GO:0007616	1/966	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8XSP3N	GO:0004190	1/966	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8XSP3N	GO:0007614	1/966	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8CNT4W	GO:0005524	32/105	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CNT4W	GO:0005737	32/105	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CNT4W	GO:0004827	27/105	proline-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15]
EOG8CNT4W	GO:0006433	27/105	prolyl-tRNA aminoacylation	biological_process	"The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510]
EOG8CNT4W	GO:0006424	22/105	glutamyl-tRNA aminoacylation	biological_process	"The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8CNT4W	GO:0004818	22/105	glutamate-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17]
EOG8CNT4W	GO:0003723	1/105	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CNT4W	GO:0006418	1/105	tRNA aminoacylation for protein translation	biological_process	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]
EOG8CNT4W	GO:0004812	1/105	aminoacyl-tRNA ligase activity	molecular_function	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
EOG8CNT4W	GO:0004819	1/105	glutamine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18]
EOG8R52K6	GO:0006351	5/31	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8R52K6	GO:0005634	5/31	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8R52K6	GO:0043565	5/31	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8R52K6	GO:0008270	5/31	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8R52K6	GO:0003700	5/31	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8PG8HC	GO:0046872	4/16	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8PG8HC	GO:0003676	3/16	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WQ3JD	GO:0003735	26/91	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8WQ3JD	GO:0005840	26/91	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8WQ3JD	GO:0006412	26/91	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8WQ3JD	GO:0007052	1/91	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8WQ3JD	GO:0000022	1/91	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8VT8BT	GO:0003995	32/99	acyl-CoA dehydrogenase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]
EOG8VT8BT	GO:0050660	31/99	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8VT8BT	GO:0043958	2/99	acryloyl-CoA reductase activity	molecular_function	"Catalysis of the reaction: acryloyl-CoA + NADH + H+ + a reduced electron-transfer flavoprotein = propionyl-CoA + NAD+ + an oxidized electron-transfer flavoprotein." [GOC:jl, PMID:12603323]
EOG8VT8BT	GO:0005811	1/99	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8VT8BT	GO:0005739	1/99	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8VT8BT	GO:0005759	1/99	mitochondrial matrix	cellular_component	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]
EOG8VT8BT	GO:0005875	1/99	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8VT8BT	GO:0006635	1/99	fatty acid beta-oxidation	biological_process	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]
EOG8VT8BT	GO:0005524	1/99	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8D81M0	GO:0005524	24/84	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8D81M0	GO:0043141	24/84	ATP-dependent 5'-3' DNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl]
EOG8D81M0	GO:0042127	3/84	regulation of cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
EOG8D81M0	GO:0006355	3/84	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8D81M0	GO:0006310	3/84	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8D81M0	GO:0031011	3/84	Ino80 complex	cellular_component	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820]
EOG8D81M0	GO:0006281	3/84	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8D81M0	GO:0030111	3/84	regulation of Wnt signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]
EOG8D81M0	GO:0006351	3/84	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8D81M0	GO:0003713	3/84	transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8D81M0	GO:0007049	2/84	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG8D81M0	GO:0016568	2/84	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG8D81M0	GO:0051301	2/84	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8D81M0	GO:0005634	1/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D81M0	GO:0005515	1/84	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8D81M0	GO:0005875	1/84	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8D81M0	GO:0090307	1/84	mitotic spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis." [GOC:tb, GOC:vw]
EOG8D81M0	GO:0010628	1/84	positive regulation of gene expression	biological_process	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8D81M0	GO:0043486	1/84	histone exchange	biological_process	"The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]
EOG8D81M0	GO:0035267	1/84	NuA4 histone acetyltransferase complex	cellular_component	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]
EOG8D81M0	GO:0007095	1/84	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8D81M0	GO:0035060	1/84	brahma complex	cellular_component	"A SWI/SNF-type complex that contains the ATPase product of the Drosophila brahma gene, or an ortholog thereof." [GOC:bf, PMID:10809665, PMID:12482982]
EOG8D81M0	GO:0016573	1/84	histone acetylation	biological_process	"The modification of a histone by the addition of an acetyl group." [GOC:ai]
EOG8KH5BG	GO:0000166	18/111	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8KH5BG	GO:0003676	16/111	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KH5BG	GO:0046872	7/111	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8C8B71	GO:0001671	25/86	ATPase activator activity	molecular_function	"Binds to and increases the ATP hydrolysis activity of an ATPase." [GOC:ajp]
EOG8C8B71	GO:0006950	24/86	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8C8B71	GO:0007076	1/86	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8NZX80	GO:0006289	26/94	nucleotide-excision repair	biological_process	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]
EOG8NZX80	GO:0000439	26/94	core TFIIH complex	cellular_component	"The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015]
EOG8NZX80	GO:0006351	25/94	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8NZX80	GO:0008270	20/94	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NZX80	GO:0005675	1/94	holo TFIIH complex	cellular_component	"A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of  the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]
EOG8NZX80	GO:0016020	1/94	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NZX80	GO:2001141	1/94	regulation of RNA biosynthetic process	biological_process	"Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph]
EOG8NZX80	GO:0006367	1/94	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG8NZX80	GO:0004872	1/94	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8NZX80	GO:0006366	1/94	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8NZX80	GO:0035556	1/94	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8NZX80	GO:0007275	1/94	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8C8B7K	GO:0004190	2/31	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8NZX84	GO:0008201	26/89	heparin binding	molecular_function	"Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]
EOG8NZX84	GO:0005783	26/89	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8NZX84	GO:0005875	1/89	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8C8B7G	GO:0016021	3/87	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D81MD	GO:0046872	26/86	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8D81MD	GO:0003824	21/86	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8D81MD	GO:0004222	3/86	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8D81MD	GO:0016787	1/86	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8D81MD	GO:0008121	1/86	ubiquinol-cytochrome-c reductase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]
EOG8D81MD	GO:0005811	1/86	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8D81MD	GO:0005739	1/86	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8D81MD	GO:0005875	1/86	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8Q2GZZ	GO:0003676	1/9	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VT8B9	GO:0016021	63/217	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VT8B9	GO:0004930	44/217	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8VT8B9	GO:0001607	19/217	neuromedin U receptor activity	molecular_function	"Combining with neuromedin U to initiate a change in cell activity." [GOC:ai]
EOG8VT8B9	GO:0036401	3/217	pyrokinin receptor activity	molecular_function	"Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation." [GOC:ha, PMID:12951076, PMID:19186060]
EOG8VT8B9	GO:0050254	3/217	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8VT8B9	GO:0007218	3/217	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8VT8B9	GO:0005887	3/217	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VT8B9	GO:0007186	3/217	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8VT8B9	GO:0008188	3/217	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8VT8B9	GO:0001653	1/217	peptide receptor activity	molecular_function	"Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl]
EOG8JWXWN	GO:0016021	1/73	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D2962	GO:0003964	185/1227	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8D2962	GO:0003723	151/1227	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8D2962	GO:0004519	49/1227	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8D2962	GO:0006355	11/1227	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8D2962	GO:0003676	2/1227	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8D2962	GO:0003677	2/1227	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8D2962	GO:0008270	1/1227	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D2962	GO:0046872	1/1227	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8D2962	GO:0008234	1/1227	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8D2962	GO:0050660	1/1227	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8D2962	GO:0016021	1/1227	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D2962	GO:0008033	1/1227	tRNA processing	biological_process	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]
EOG8D2962	GO:0005634	1/1227	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D2962	GO:0022857	1/1227	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8JWXWV	GO:0043039	15/67	tRNA aminoacylation	biological_process	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]
EOG8JWXWV	GO:0005524	15/67	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8JWXWV	GO:0016876	15/67	ligase activity, forming aminoacyl-tRNA and related compounds	molecular_function	"Catalysis of the joining of an amino acid and a nucleic acid (usually tRNA) or poly(ribitol phosphate), with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. The reaction forms an aminoacyl-tRNA or a related compound." [EC:6.1.1, GOC:mah]
EOG8JWXWV	GO:0005737	15/67	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8JWXWV	GO:0003746	2/67	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG8JWXWV	GO:0005875	1/67	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8D2968	GO:0003677	56/1616	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8D2968	GO:0006313	36/1616	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG8D2968	GO:0015074	36/1616	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8D2968	GO:0004803	36/1616	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG8D2968	GO:0006355	9/1616	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8D2968	GO:0008270	4/1616	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D2968	GO:0007275	3/1616	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8D2968	GO:0005634	3/1616	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D2968	GO:0006351	3/1616	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8NKF8C	GO:0016021	5/107	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NKF8C	GO:0046872	2/107	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NKF8C	GO:0000166	2/107	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8HB11K	GO:0046580	1/89	negative regulation of Ras protein signal transduction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
EOG88972Q	GO:0016021	3/95	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RR8X4	GO:0004181	11/70	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG8RR8X4	GO:0008270	11/70	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81NX41	GO:0016021	3/67	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG844P31	GO:0003824	23/78	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG844P31	GO:0004467	2/78	long-chain fatty acid-CoA ligase activity	molecular_function	"Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.3]
EOG844P31	GO:0016874	1/78	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG844P31	GO:0008756	1/78	o-succinylbenzoate-CoA ligase activity	molecular_function	"Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate." [EC:6.2.1.26]
EOG8S7N6P	GO:0051491	1/78	positive regulation of filopodium assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG8S7N6P	GO:0008582	1/78	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8S7N6P	GO:0051259	1/78	protein oligomerization	biological_process	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
EOG8S7N6P	GO:0021551	1/78	central nervous system morphogenesis	biological_process	"The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089]
EOG8S7N6P	GO:0008360	1/78	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8S7N6P	GO:0010592	1/78	positive regulation of lamellipodium assembly	biological_process	"Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG86MF1H	GO:0004871	28/103	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG86MF1H	GO:0005634	24/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86MF1H	GO:0006355	23/103	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG86MF1H	GO:0006351	23/103	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG86MF1H	GO:0003677	23/103	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86MF1H	GO:0003700	2/103	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG86MF1H	GO:0046982	1/103	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG86MF1H	GO:0043565	1/103	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG86MF1H	GO:0006366	1/103	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG86MF1H	GO:0005667	1/103	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG86MF1H	GO:0000981	1/103	RNA polymerase II transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
EOG86MF1H	GO:0072175	1/103	epithelial tube formation	biological_process	"The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10]
EOG86MF1H	GO:0048813	1/103	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG86MF1H	GO:0045944	1/103	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG86MF1H	GO:0046331	1/103	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG86MF1H	GO:0007443	1/103	Malpighian tubule morphogenesis	biological_process	"The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089]
EOG86MF1H	GO:0007431	1/103	salivary gland development	biological_process	"The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044]
EOG86MF1H	GO:0035277	1/103	spiracle morphogenesis, open tracheal system	biological_process	"The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268]
EOG86MF1H	GO:0007424	1/103	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG86MF1H	GO:0007425	1/103	epithelial cell fate determination, open tracheal system	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940]
EOG86MF1H	GO:0005737	1/103	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86MF1H	GO:0007435	1/103	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG86MF1W	GO:0005085	23/77	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG86MF1W	GO:0007264	23/77	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG86MF1W	GO:0008270	1/77	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG86MF1W	GO:0015031	1/77	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG89GP04	GO:0003677	1/69	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG89GP04	GO:0005737	1/69	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG89GP04	GO:0005700	1/69	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG89GP04	GO:0042803	1/69	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG89GP04	GO:0035102	1/69	PRC1 complex	cellular_component	"A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979]
EOG89GP04	GO:0007076	1/69	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG89GP04	GO:0007474	1/69	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG89GP04	GO:0005813	1/69	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG89GP04	GO:0060429	1/69	epithelium development	biological_process	"The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]
EOG89GP04	GO:0035098	1/69	ESC/E(Z) complex	cellular_component	"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]
EOG89GP04	GO:0010468	1/69	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG89GP04	GO:0005634	1/69	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG89GP04	GO:0006342	1/69	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG89GP04	GO:0005515	1/69	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG89GP04	GO:0005911	1/69	cell-cell junction	cellular_component	"A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah]
EOG89GP04	GO:0042802	1/69	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG89GP04	GO:0045433	1/69	male courtship behavior, veined wing generated song production	biological_process	"The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
EOG89GP04	GO:0003682	1/69	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8S7N6K	GO:0000166	1/33	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8TXF88	GO:0016021	4/78	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CJXZG	GO:0003899	2/211	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8CJXZG	GO:0003677	2/211	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CJXZG	GO:0006351	2/211	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8CJXZG	GO:0003676	1/211	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8P2SJ2	GO:0015074	13/185	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8P2SJ2	GO:0003677	13/185	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8P2SJ2	GO:0006310	13/185	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8P2SJ2	GO:0003964	2/185	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8P2SJ2	GO:0003723	2/185	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8MGVNG	GO:0003755	24/87	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8MGVNG	GO:0006457	24/87	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8MGVNG	GO:0071013	1/87	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8MGVNG	GO:0000398	1/87	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8F4VQV	GO:0005524	3/138	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8F4VQV	GO:0004674	2/138	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8F4VQV	GO:0032440	1/138	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8F4VQV	GO:0004672	1/138	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8F4VQV	GO:0016772	1/138	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8S7N63	GO:0016021	6/38	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S7N63	GO:0016286	6/38	small conductance calcium-activated potassium channel activity	molecular_function	"Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754]
EOG82VBWR	GO:0004707	24/98	MAP kinase activity	molecular_function	"Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]
EOG82VBWR	GO:0005524	24/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82VBWR	GO:0034614	1/98	cellular response to reactive oxygen species	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah]
EOG82VBWR	GO:0045467	1/98	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG82VBWR	GO:0008595	1/98	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG82VBWR	GO:0005737	1/98	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82VBWR	GO:0048149	1/98	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG82VBWR	GO:0071276	1/98	cellular response to cadmium ion	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:mah]
EOG82VBWR	GO:0019901	1/98	protein kinase binding	molecular_function	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]
EOG82VBWR	GO:0030054	1/98	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG82VBWR	GO:0090303	1/98	positive regulation of wound healing	biological_process	"Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF]
EOG82VBWR	GO:0008134	1/98	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG82VBWR	GO:0005634	1/98	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82VBWR	GO:2001023	1/98	regulation of response to drug	biological_process	"Any process that modulates the frequency, rate or extent of response to drug." [GOC:obol]
EOG82VBWR	GO:0034334	1/98	adherens junction maintenance	biological_process	"The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah]
EOG82VBWR	GO:0004674	1/98	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG82VBWR	GO:0007258	1/98	JUN phosphorylation	biological_process	"The process of introducing a phosphate group into a JUN protein." [GOC:jl]
EOG82VBWR	GO:0043066	1/98	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG82VBWR	GO:0006355	1/98	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82VBWR	GO:0007067	1/98	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG82VBWR	GO:0007552	1/98	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG82VBWR	GO:0007474	1/98	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG82VBWR	GO:0000165	1/98	MAPK cascade	biological_process	"An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267]
EOG82VBWR	GO:0008293	1/98	torso signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
EOG82VBWR	GO:0046534	1/98	positive regulation of photoreceptor cell differentiation	biological_process	"Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
EOG82VBWR	GO:0008586	1/98	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG82VBWR	GO:0006974	1/98	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG82VBWR	GO:0071243	1/98	cellular response to arsenic-containing substance	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:mah]
EOG82VBWR	GO:0004705	1/98	JUN kinase activity	molecular_function	"Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors." [GOC:bf, ISBN:0198506732]
EOG82VBWR	GO:0007507	1/98	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG82VBWR	GO:0007476	1/98	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG82VBWR	GO:0009267	1/98	cellular response to starvation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]
EOG82VBWR	GO:0008284	1/98	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG82VBWR	GO:0007169	1/98	transmembrane receptor protein tyrosine kinase signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
EOG82VBWR	GO:0050804	1/98	modulation of synaptic transmission	biological_process	"Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
EOG82VBWR	GO:0006468	1/98	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG82VBWR	GO:0016242	1/98	negative regulation of macroautophagy	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]
EOG82VBWR	GO:0005515	1/98	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG82VBWR	GO:0007369	1/98	gastrulation	biological_process	"A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]
EOG82VBWR	GO:0050803	1/98	regulation of synapse structure or activity	biological_process	"Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]
EOG8MGVNT	GO:0005524	51/177	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8MGVNT	GO:0008026	49/177	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8MGVNT	GO:0003676	44/177	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MGVNT	GO:0003743	7/177	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8MGVNT	GO:0005634	2/177	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8MGVNT	GO:0016281	2/177	eukaryotic translation initiation factor 4F complex	cellular_component	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:8449919]
EOG8MGVNT	GO:0006413	2/177	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG8MGVNT	GO:0006974	2/177	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8MGVNT	GO:0005875	1/177	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8MGVNT	GO:0048477	1/177	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8MGVNT	GO:0005813	1/177	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8MGVNT	GO:0071011	1/177	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8MGVNT	GO:0007067	1/177	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8MGVNT	GO:0007052	1/177	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8MGVNT	GO:0002168	1/177	instar larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8MGVNT	GO:0030718	1/177	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8MGVNT	GO:0003724	1/177	RNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah]
EOG8MGVNT	GO:0000022	1/177	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8MGVNT	GO:0000398	1/177	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8MGVNT	GO:0006200	1/177	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8MGVNT	GO:0072686	1/177	mitotic spindle	cellular_component	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
EOG8MGVNT	GO:0051297	1/177	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8MGVNT	GO:0008380	1/177	RNA splicing	biological_process	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]
EOG8MGVNT	GO:0045451	1/177	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8MGVNT	GO:0005515	1/177	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8MGVNT	GO:0007446	1/177	imaginal disc growth	biological_process	"The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387]
EOG8MGVNT	GO:0048132	1/177	female germ-line stem cell asymmetric division	biological_process	"The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu]
EOG8MGVNT	GO:0004004	1/177	ATP-dependent RNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8MGVNT	GO:0005829	1/177	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8MGVNT	GO:0071013	1/177	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8MGVNT	GO:0004386	1/177	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8MGVNT	GO:0000381	1/177	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8MGVNT	GO:0045495	1/177	pole plasm	cellular_component	"Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380]
EOG8RR8XC	GO:0005604	1/94	basement membrane	cellular_component	"A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]
EOG8RR8XC	GO:0016020	1/94	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RR8XC	GO:0007155	1/94	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8RR8XC	GO:0006914	1/94	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG8RR8XC	GO:0004871	1/94	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8RZ1G4	GO:0005549	13/23	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8RZ1G4	GO:0005576	1/23	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8RZ1G4	GO:0007606	1/23	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8HB119	GO:0005886	3/27	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8HB119	GO:0016021	3/27	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HB119	GO:0004984	3/27	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8HB119	GO:0004930	3/27	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8HB119	GO:0005549	3/27	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8GXJ3X	GO:0005576	7/71	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8GXJ3X	GO:0006869	7/71	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG8GXJ3X	GO:0008289	7/71	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG8QC3N1	GO:0042073	24/80	intraciliary transport	biological_process	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374]
EOG8QC3N1	GO:0042384	1/80	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8C8B84	GO:0016021	24/83	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C8B84	GO:0000139	2/83	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8C8B84	GO:0005886	2/83	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8C8B84	GO:0007431	2/83	salivary gland development	biological_process	"The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044]
EOG8C8B84	GO:0051119	2/83	sugar transmembrane transporter activity	molecular_function	"Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8C8B84	GO:0034219	2/83	carbohydrate transmembrane transport	biological_process	"The process in which a carbohydrate is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8KD93D	GO:0007111	1/82	meiosis II cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8KD93D	GO:0000915	1/82	actomyosin contractile ring assembly	biological_process	"The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
EOG8KD93D	GO:0007110	1/82	meiosis I cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8KD93D	GO:0005737	1/82	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8KD93D	GO:0032133	1/82	chromosome passenger complex	cellular_component	"A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910]
EOG8KD93D	GO:0046331	1/82	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8KD93D	GO:0043066	1/82	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8KD93D	GO:0007051	1/82	spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:mah]
EOG8KD93D	GO:0022008	1/82	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8KD93D	GO:0051225	1/82	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG83BQ4N	GO:0000166	25/86	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG83BQ4N	GO:0000184	1/86	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	biological_process	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]
EOG866Z24	GO:0008168	26/88	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG866Z24	GO:0022008	1/88	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG83BQ4M	GO:0005085	6/45	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG83BQ4M	GO:0007264	6/45	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8642TH	GO:0042626	41/94	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8642TH	GO:0015992	2/94	proton transport	biological_process	"The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
EOG8642TH	GO:0000221	1/94	vacuolar proton-transporting V-type ATPase, V1 domain	cellular_component	"The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG8642TH	GO:0015991	1/94	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8642TH	GO:0033181	1/94	plasma membrane proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
EOG8642TH	GO:0005886	1/94	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8H1D8R	GO:0004842	26/92	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8H1D8R	GO:0005737	1/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8H1D8R	GO:0005634	1/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8H1D8R	GO:0042787	1/92	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological_process	"The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]
EOG8Z91BT	GO:0006166	2/30	purine ribonucleoside salvage	biological_process	"Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl]
EOG8Z91BT	GO:0004001	2/30	adenosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943]
EOG8Z91BT	GO:0016773	1/30	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8GF5VB	GO:0000226	28/99	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8GF5VB	GO:0005874	28/99	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8GF5VB	GO:0007017	1/99	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8GF5VB	GO:0008017	1/99	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8GF5VB	GO:0005875	1/99	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG83BQ49	GO:0006412	26/86	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG83BQ49	GO:0003735	26/86	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG83BQ49	GO:0005840	26/86	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG83BQ49	GO:0000462	1/86	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	biological_process	"Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
EOG83BQ49	GO:0022627	1/86	cytosolic small ribosomal subunit	cellular_component	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]
EOG83BQ49	GO:0006414	1/86	translational elongation	biological_process	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]
EOG83BQ49	GO:0022008	1/86	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8KD930	GO:0010309	27/90	acireductone dioxygenase [iron(II)-requiring] activity	molecular_function	"Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+)." [EC:1.13.11.54, RHEA:24507]
EOG8KD930	GO:0005737	27/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8KD930	GO:0005506	27/90	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8KD930	GO:0005634	27/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8KD930	GO:0019509	27/90	L-methionine biosynthetic process from methylthioadenosine	biological_process	"The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361]
EOG8KD930	GO:0016491	1/90	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8KD930	GO:0005886	1/90	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8Z91BB	GO:0015074	44/793	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8Z91BB	GO:0003676	43/793	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Z91BB	GO:0003964	17/793	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8Z91BB	GO:0003723	15/793	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8Z91BB	GO:0003677	6/793	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Z91BB	GO:0008270	4/793	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Z91BB	GO:0004523	2/793	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8Z91BB	GO:0005622	1/793	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8Z91BB	GO:0019028	1/793	viral capsid	cellular_component	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
EOG8Z91BB	GO:0046718	1/793	viral entry into host cell	biological_process	"The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm." [GOC:jl]
EOG8Z91BB	GO:0019076	1/793	viral release from host cell	biological_process	"The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane." [GOC:jl]
EOG8Z91BB	GO:0006351	1/793	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8Z91BB	GO:0003899	1/793	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8Z91BB	GO:0044163	1/793	host cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of host cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the host cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the host cell. The various elements of the host cytoskeleton not only serve in the maintenance of host cellular shape but also have roles in other host cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:rph]
EOG8Z91BB	GO:0075521	1/793	microtubule-dependent intracellular transport of viral material towards nucleus	biological_process	"The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules." [UniProtKB-KW:KW-1177, VZ:983]
EOG8Z91BB	GO:0042025	1/793	host cell nucleus	cellular_component	"A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
EOG8Z91BB	GO:0030430	1/793	host cell cytoplasm	cellular_component	"The cytoplasm of a host cell." [GOC:mah]
EOG8Z91BB	GO:0004190	1/793	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8KD936	GO:0016021	77/225	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KD936	GO:0005918	3/225	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG8KD936	GO:0019991	3/225	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG8KD936	GO:0060857	3/225	establishment of glial blood-brain barrier	biological_process	"Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
EOG8KD936	GO:0035151	2/225	regulation of tube size, open tracheal system	biological_process	"Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]
EOG8KD936	GO:0007424	2/225	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8KD936	GO:0005919	1/225	pleated septate junction	cellular_component	"A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298]
EOG8KD936	GO:0005198	1/225	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8KD936	GO:0005923	1/225	bicellular tight junction	cellular_component	"An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181]
EOG8KD936	GO:0005886	1/225	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8KD936	GO:0061343	1/225	cell adhesion involved in heart morphogenesis	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
EOG8KD936	GO:0005515	1/225	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KD936	GO:0035159	1/225	regulation of tube length, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
EOG8KD936	GO:0003015	1/225	heart process	biological_process	"A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]
EOG8KD936	GO:0007391	1/225	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8KD936	GO:0035002	1/225	liquid clearance, open tracheal system	biological_process	"The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352]
EOG8QC3NM	GO:0016020	38/153	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QC3NM	GO:0016202	2/153	regulation of striated muscle tissue development	biological_process	"Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators]
EOG8QC3NM	GO:0005515	2/153	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QC3NM	GO:0005886	2/153	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8QC3NM	GO:0007520	2/153	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG8QC3NM	GO:0007156	2/153	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8QC3NM	GO:0001745	2/153	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8QC3NM	GO:0005912	1/153	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8QC3NM	GO:0036059	1/153	nephrocyte diaphragm assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]
EOG8QC3NM	GO:0097206	1/153	nephrocyte filtration	biological_process	"The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929]
EOG8QC3NM	GO:0007157	1/153	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]
EOG8QC3NM	GO:0030165	1/153	PDZ domain binding	molecular_function	"Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]
EOG8QC3NM	GO:0016021	1/153	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QC3NM	GO:0005913	1/153	cell-cell adherens junction	cellular_component	"An adherens junction which connects a cell to another cell." [GOC:hb]
EOG8QC3NM	GO:0046667	1/153	compound eye retinal cell programmed cell death	biological_process	"Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672]
EOG8QC3NM	GO:0045177	1/153	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8QC3NM	GO:0048749	1/153	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8QC3NM	GO:0046666	1/153	retinal cell programmed cell death	biological_process	"Programmed cell death that occurs in the developing retina." [GOC:bf]
EOG8QC3NM	GO:0061321	1/153	garland nephrocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000486, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]
EOG8QC3NM	GO:0007523	1/153	larval visceral muscle development	biological_process	"The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid]
EOG8QC3NM	GO:1901739	1/153	regulation of myoblast fusion	biological_process	"Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]
EOG8QC3NM	GO:0005917	1/153	nephrocyte diaphragm	cellular_component	"A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]
EOG8QC3NM	GO:0050839	1/153	cell adhesion molecule binding	molecular_function	"Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai]
EOG8QC3NM	GO:0009986	1/153	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8QC3NM	GO:0046331	1/153	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8QC3NM	GO:0036058	1/153	filtration diaphragm assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, PMID:18971929]
EOG866Z2Q	GO:0005525	19/62	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG866Z2Q	GO:0007264	19/62	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG866Z2Q	GO:0015031	16/62	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG866Z2Q	GO:0005515	1/62	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG866Z2Q	GO:0008021	1/62	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG866Z2Q	GO:0045202	1/62	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG866Z2Q	GO:0030431	1/62	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8GXJ37	GO:0016021	24/85	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GXJ37	GO:0008236	24/85	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8GXJ37	GO:0006465	24/85	signal peptide processing	biological_process	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]
EOG8GXJ30	GO:0022008	1/72	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8MD0FT	GO:0004725	1/45	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8GJ23D	GO:0007165	1/92	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8MD0FH	GO:0003676	1/47	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MD0FH	GO:0008270	1/47	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FFGHB	GO:0006950	26/583	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8FFGHB	GO:0005212	9/583	structural constituent of eye lens	molecular_function	"The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah]
EOG8FFGHB	GO:0008340	3/583	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8FFGHB	GO:0005875	3/583	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8FFGHB	GO:0010998	2/583	regulation of translational initiation by eIF2 alpha phosphorylation	biological_process	"Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha." [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb]
EOG8FFGHB	GO:0009631	2/583	cold acclimation	biological_process	"Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr]
EOG8FFGHB	GO:0005515	2/583	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FFGHB	GO:0007275	1/583	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8FFGHB	GO:0017022	1/583	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8FFGHB	GO:0042595	1/583	behavioral response to starvation	biological_process	"Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators]
EOG8FFGHB	GO:0009408	1/583	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8FFGHB	GO:0007476	1/583	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8FFGHB	GO:0010506	1/583	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8FFGHB	GO:0003779	1/583	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8FFGHB	GO:0006497	1/583	protein lipidation	biological_process	"The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]
EOG8FFGHB	GO:0001666	1/583	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG8FFGHB	GO:0006979	1/583	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8FFGHB	GO:0031427	1/583	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG8FFGHB	GO:0050832	1/583	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8FFGHB	GO:0042742	1/583	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8XD67H	GO:0016874	2/16	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8TMTGW	GO:0016020	16/70	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8TMTGW	GO:0007157	1/70	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]
EOG8BS01Z	GO:0007165	1/42	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8TMTGQ	GO:0016021	1/80	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BS01X	GO:0020037	23/68	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8BS01X	GO:0046331	1/68	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8MSGC0	GO:0004601	52/183	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG8MSGC0	GO:0006979	52/183	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8MSGC0	GO:0020037	52/183	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8MSGC0	GO:0060967	1/183	negative regulation of gene silencing by RNA	biological_process	"Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb]
EOG8MSGC0	GO:0016758	1/183	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8MSGC0	GO:0070189	1/183	kynurenine metabolic process	biological_process	"The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph]
EOG8MSGC0	GO:0005764	1/183	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8MSGC0	GO:1901216	1/183	positive regulation of neuron death	biological_process	"Any process that activates or increases the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]
EOG8MSGC0	GO:0006727	1/183	ommochrome biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
EOG8FTZFM	GO:0004721	23/82	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8FTZFM	GO:0005634	23/82	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FTZFM	GO:0046872	1/82	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8MSGC7	GO:0016905	2/97	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG8MSGC7	GO:0035147	1/97	branch fusion, open tracheal system	biological_process	"Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584]
EOG8MSGC7	GO:1900038	1/97	negative regulation of cellular response to hypoxia	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia." [GOC:TermGenie, GOC:yaf]
EOG8MSGC7	GO:0060438	1/97	trachea development	biological_process	"The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG8MSGC7	GO:0007088	1/97	regulation of mitotic nuclear division	biological_process	"Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
EOG8MSGC7	GO:0008054	1/97	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation	biological_process	"The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions via the negative regulation of a cyclin-dependent kinase." [GOC:mah, PMID:15840442]
EOG8MSGC7	GO:0071456	1/97	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG8MSGC7	GO:0031146	1/97	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]
EOG8MSGC7	GO:0007411	1/97	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8MSGC7	GO:0019005	1/97	SCF ubiquitin ligase complex	cellular_component	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
EOG8MSGC7	GO:0042023	1/97	DNA endoreduplication	biological_process	"Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw]
EOG8MSGC7	GO:0030162	1/97	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8MSGC7	GO:0045926	1/97	negative regulation of growth	biological_process	"Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
EOG8MSGC7	GO:0016567	1/97	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8MSGC7	GO:0060253	1/97	negative regulation of glial cell proliferation	biological_process	"Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb]
EOG8MSGC7	GO:0005634	1/97	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8MSGC7	GO:0030332	1/97	cyclin binding	molecular_function	"Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai]
EOG8MSGC7	GO:0005515	1/97	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8MSGC7	GO:0007096	1/97	regulation of exit from mitosis	biological_process	"Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn]
EOG8NW21H	GO:0003677	23/84	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NW21H	GO:0008168	23/84	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8NW21H	GO:0006306	23/84	DNA methylation	biological_process	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]
EOG8NW21H	GO:0003886	2/84	DNA (cytosine-5-)-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37]
EOG8NW21H	GO:0004379	2/84	glycylpeptide N-tetradecanoyltransferase activity	molecular_function	"Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97]
EOG8NW21H	GO:0090116	1/84	C-5 methylation of cytosine	biological_process	"The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8NW21H	GO:0000723	1/84	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8NW21H	GO:0030488	1/84	tRNA methylation	biological_process	"The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]
EOG8NW21H	GO:0008175	1/84	tRNA methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah]
EOG8NW21H	GO:0009408	1/84	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8NW21H	GO:0044026	1/84	DNA hypermethylation	biological_process	"An increase in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/]
EOG8NW21H	GO:0045089	1/84	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8NW21H	GO:0010494	1/84	cytoplasmic stress granule	cellular_component	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]
EOG8NW21H	GO:0008340	1/84	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8NW21H	GO:0016363	1/84	nuclear matrix	cellular_component	"The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]
EOG8NW21H	GO:0006979	1/84	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8NW21H	GO:0002230	1/84	positive regulation of defense response to virus by host	biological_process	"Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
EOG8NW21H	GO:0043045	1/84	DNA methylation involved in embryo development	biological_process	"The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression." [GOC:go_curators, PMID:12138111]
EOG8NW21H	GO:0005634	1/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NW21H	GO:0016458	1/84	gene silencing	biological_process	"Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb]
EOG8WWV0X	GO:0004930	20/67	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8WWV0X	GO:0016021	20/67	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WWV0X	GO:0007218	2/67	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8WWV0X	GO:0050254	1/67	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8WWV0X	GO:0007186	1/67	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8WWV0X	GO:0008188	1/67	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8PRW6R	GO:0016491	44/293	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8PRW6R	GO:0004022	8/293	alcohol dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
EOG8PRW6R	GO:0016404	4/293	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	molecular_function	"Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141]
EOG8PRW6R	GO:0003939	1/293	L-iditol 2-dehydrogenase activity	molecular_function	"Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14]
EOG8PRW6R	GO:0006066	1/293	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG8BS01B	GO:0005215	139/496	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8BS01B	GO:0005622	138/496	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8BS01B	GO:0016787	14/496	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8BS01B	GO:0005811	1/496	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8B014Z	GO:0016020	27/111	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8B014Z	GO:0046873	27/111	metal ion transmembrane transporter activity	molecular_function	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]
EOG8J13R9	GO:0000166	23/89	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8J13R9	GO:0003676	22/89	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8J13R9	GO:0003729	1/89	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8B014N	GO:0022008	1/92	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8B014B	GO:0005887	1/105	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8B014B	GO:0046331	1/105	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG89W4VX	GO:0004984	10/20	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG89W4VX	GO:0016021	10/20	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89W4VX	GO:0004930	10/20	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG89W4VX	GO:0005549	10/20	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG89W4VX	GO:0005886	8/20	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG89W4VX	GO:0050911	1/20	detection of chemical stimulus involved in sensory perception of smell	biological_process	"The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8B0140	GO:0005506	10/60	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8B0140	GO:0006633	10/60	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8B0140	GO:0016491	10/60	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8B0140	GO:0016021	9/60	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J13RV	GO:0008234	23/47	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8J13RV	GO:0007616	1/47	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8J13RV	GO:0004869	1/47	cysteine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb]
EOG8J13RV	GO:0007614	1/47	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8J13RV	GO:0010951	1/47	negative regulation of endopeptidase activity	biological_process	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG8X0Q73	GO:0016021	23/72	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X0Q73	GO:0005267	23/72	potassium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG86T5HW	GO:0005681	11/34	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG86T5HW	GO:0000398	11/34	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG86T5HW	GO:0019013	2/34	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG86T5HW	GO:0003723	1/34	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG86T5HW	GO:0071011	1/34	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG86T5HW	GO:0005634	1/34	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86T5HW	GO:0071013	1/34	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG86T5HW	GO:0030532	1/34	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8XD679	GO:0006412	25/85	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8XD679	GO:0005840	25/85	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8XD679	GO:0003735	25/85	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8XD679	GO:0000022	1/85	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8XD679	GO:0051298	1/85	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8XD679	GO:0007052	1/85	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8XD679	GO:0022008	1/85	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG89W4XH	GO:0016740	1/16	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG89W4XH	GO:0016021	1/16	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87Q0PC	GO:0016021	1/8	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87Q0PC	GO:0007155	1/8	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG87H851	GO:0001522	25/83	pseudouridine synthesis	biological_process	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]
EOG87H851	GO:0009982	25/83	pseudouridine synthase activity	molecular_function	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]
EOG87H851	GO:0003723	25/83	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG87H851	GO:0008033	24/83	tRNA processing	biological_process	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]
EOG87H851	GO:0016829	1/83	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8284H1	GO:0005509	25/85	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8284H1	GO:0032440	2/85	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG89W4XP	GO:0003777	3/15	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG89W4XP	GO:0007018	3/15	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG89W4XP	GO:0005871	3/15	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG89W4XP	GO:0005524	3/15	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG89W4XP	GO:0005874	3/15	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8284H3	GO:0003700	6/29	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8284H3	GO:0005634	6/29	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8284H3	GO:0043565	6/29	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8284H3	GO:0006950	3/29	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8284H3	GO:0005576	1/29	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG80KBG7	GO:0006412	26/88	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG80KBG7	GO:0005840	26/88	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG80KBG7	GO:0003735	26/88	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG80KBG7	GO:0007052	1/88	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG80KBG7	GO:0000022	1/88	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG80KBG7	GO:0046872	1/88	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80KBG9	GO:0003676	5/20	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80KBG9	GO:0008270	4/20	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80KBG9	GO:0015074	1/20	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8QVFTV	GO:0005634	10/97	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8QVFTV	GO:0003700	10/97	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8QVFTV	GO:0003677	1/97	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8QVFTV	GO:0000122	1/97	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8QVFTV	GO:0006355	1/97	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8QVFTV	GO:0006351	1/97	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8QVFTV	GO:0046982	1/97	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG87Q0N8	GO:0017176	2/74	phosphatidylinositol N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]
EOG87Q0N8	GO:0016757	1/74	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG87Q0N9	GO:0003700	23/108	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG87Q0N9	GO:0043565	23/108	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG87Q0N9	GO:0005634	21/108	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87Q0N9	GO:0046983	1/108	protein dimerization activity	molecular_function	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]
EOG87Q0N9	GO:0003677	1/108	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG87Q0N9	GO:0040040	1/108	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG87Q0N9	GO:0006351	1/108	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG87Q0N9	GO:0007611	1/108	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG87Q0N9	GO:0007623	1/108	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG87Q0N9	GO:0045944	1/108	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG87Q0N9	GO:0045187	1/108	regulation of circadian sleep/wake cycle, sleep	biological_process	"Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981]
EOG87Q0N9	GO:2000253	1/108	positive regulation of feeding behavior	biological_process	"Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol]
EOG87Q0N9	GO:0072375	1/108	medium-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster)." [GOC:sart, PMID:14659098, PMID:7923375]
EOG87Q0N9	GO:0007528	1/108	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG87Q0N9	GO:0045475	1/108	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG87Q0N9	GO:0007616	1/108	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG87Q0N9	GO:0006355	1/108	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG87Q0N9	GO:0030431	1/108	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG87Q0N9	GO:0007622	1/108	rhythmic behavior	biological_process	"The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr]
EOG8MPM68	GO:0005549	4/54	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG84F8S6	GO:0009231	22/67	riboflavin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
EOG84F8S6	GO:0008531	22/67	riboflavin kinase activity	molecular_function	"Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+)." [EC:2.7.1.26, RHEA:14360]
EOG84F8S6	GO:0016779	1/67	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG84F8S6	GO:0009398	1/67	FMN biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [CHEBI:17621, GOC:ai]
EOG84F8S6	GO:0005524	1/67	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG84F8S6	GO:0005737	1/67	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84F8S6	GO:0046872	1/67	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85HVHB	GO:0003676	1/63	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85HVHB	GO:0046872	1/63	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG87Q0NX	GO:0003700	2/18	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG87Q0NX	GO:0005634	2/18	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87Q0NW	GO:0006457	25/72	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG87Q0NW	GO:0016272	25/72	prefoldin complex	cellular_component	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]
EOG83FKDB	GO:0003735	25/80	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG83FKDB	GO:0006412	25/80	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG83FKDB	GO:0005840	24/80	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG83FKDB	GO:0005763	1/80	mitochondrial small ribosomal subunit	cellular_component	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
EOG8BVVBZ	GO:0003676	2/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XH2GQ	GO:0042302	1098/2997	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8XH2GQ	GO:0031012	32/2997	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8XH2GQ	GO:0040003	31/2997	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8XH2GQ	GO:0008010	31/2997	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8XH2GQ	GO:0022008	2/2997	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8XH2GQ	GO:0008011	2/2997	structural constituent of pupal chitin-based cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8XH2GQ	GO:0032504	1/2997	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8XH2GQ	GO:0048058	1/2997	compound eye corneal lens development	biological_process	"The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells." [GOC:jid]
EOG8XH2GQ	GO:0005615	1/2997	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8XH2GQ	GO:0005212	1/2997	structural constituent of eye lens	molecular_function	"The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah]
EOG8XH2GQ	GO:0005576	1/2997	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8XH2GQ	GO:0005509	1/2997	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8XH2GQ	GO:0007601	1/2997	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8XH2GQ	GO:0003824	1/2997	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8XH2GQ	GO:0005811	1/2997	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG89W4X1	GO:0016021	70/141	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89W4X1	GO:0006886	41/141	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG89W4X1	GO:0005744	41/141	mitochondrial inner membrane presequence translocase complex	cellular_component	"The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659]
EOG89W4X1	GO:0015450	37/141	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	molecular_function	"Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729]
EOG89W4X1	GO:0008566	4/141	mitochondrial protein-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex." [EC:3.6.3.51]
EOG89W4X1	GO:0005739	1/141	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG89W4X1	GO:0006626	1/141	protein targeting to mitochondrion	biological_process	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]
EOG8DBWTW	GO:0016021	122/391	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DBWTW	GO:0022857	118/391	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8DBWTW	GO:0055085	3/391	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8DBWTW	GO:0005215	2/391	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8DBWTW	GO:0007390	1/391	germ-band shortening	biological_process	"The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138]
EOG8DBWTW	GO:0008643	1/391	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8DBWTW	GO:0015695	1/391	organic cation transport	biological_process	"The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai]
EOG8DBWTW	GO:0030307	1/391	positive regulation of cell growth	biological_process	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8DBWTW	GO:0015101	1/391	organic cation transmembrane transporter activity	molecular_function	"Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8DBWTW	GO:0040018	1/391	positive regulation of multicellular organism growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8DBWTW	GO:0006915	1/391	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8DBWTW	GO:0006811	1/391	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8DBWTW	GO:0032440	1/391	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8DBWTT	GO:0017150	25/88	tRNA dihydrouridine synthase activity	molecular_function	"Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710]
EOG8DBWTT	GO:0050660	25/88	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG854CCG	GO:0005643	29/97	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG854CCG	GO:0006913	29/97	nucleocytoplasmic transport	biological_process	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]
EOG854CCG	GO:0017056	29/97	structural constituent of nuclear pore	molecular_function	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex." [GOC:mah]
EOG854CCG	GO:0003824	1/97	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG854CCG	GO:0005635	1/97	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG8TXF7N	GO:0016021	1/76	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TXF7Q	GO:0004129	29/141	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8TXF7Q	GO:0005739	28/141	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8TXF7Q	GO:0008340	1/141	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8TXF7Q	GO:0022008	1/141	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG822D10	GO:0004298	41/111	threonine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG822D10	GO:0005839	41/111	proteasome core complex	cellular_component	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]
EOG822D10	GO:0051603	40/111	proteolysis involved in cellular protein catabolic process	biological_process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]
EOG822D10	GO:0005634	38/111	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG822D10	GO:0005737	38/111	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG822D10	GO:0006974	1/111	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG822D10	GO:0032504	1/111	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG822D10	GO:0009987	1/111	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG822D10	GO:0005515	1/111	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG822D10	GO:0043161	1/111	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG80CKXC	GO:0008270	28/92	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80CKXC	GO:0003676	21/92	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80CKXC	GO:0005634	1/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80CKXC	GO:0016874	1/92	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8TXF7W	GO:0006914	49/150	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG8TXF7W	GO:0005776	2/150	autophagosome	cellular_component	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]
EOG8TXF7W	GO:0016236	2/150	macroautophagy	biological_process	"The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure.  Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464]
EOG8TXF7W	GO:0008340	1/150	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8TXF7W	GO:0031396	1/150	regulation of protein ubiquitination	biological_process	"Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]
EOG8TXF7W	GO:0044753	1/150	amphisome	cellular_component	"An autophagosome formed upon fusion between autophagosomes and endosomes." [GOC:autophagy, GOC:sart, PMID:19008921, PMID:9705327]
EOG8TXF7W	GO:0010506	1/150	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8FR366	GO:0007165	22/95	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8FR366	GO:0005622	21/95	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8FR366	GO:0030042	1/95	actin filament depolymerization	biological_process	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]
EOG8FR366	GO:0045179	1/95	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8FR366	GO:0005100	1/95	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8FR366	GO:0005515	1/95	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FR366	GO:0015629	1/95	actin cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
EOG8FR366	GO:0032855	1/95	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8FR366	GO:0034259	1/95	negative regulation of GTPase activity	biological_process	"Any process that stops or reduces the rate of GTP hydrolysis by a GTPase." [GO_REF:0000058, GOC:mah, GOC:rb, GOC:TermGenie, PMID:16143306, PMID:24335649]
EOG8GQSJW	GO:0005615	39/119	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8GQSJW	GO:0008233	5/119	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8GQSJW	GO:0016740	5/119	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8GQSJW	GO:0048149	1/119	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8GQSJW	GO:0035011	1/119	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG8GQSJW	GO:0009611	1/119	response to wounding	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators]
EOG8GQSJW	GO:0008063	1/119	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8GQSJW	GO:0005576	1/119	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8GQSJW	GO:0010951	1/119	negative regulation of endopeptidase activity	biological_process	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG8GQSJW	GO:0004857	1/119	enzyme inhibitor activity	molecular_function	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai]
EOG8GQSJW	GO:0002213	1/119	defense response to insect	biological_process	"A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add]
EOG8GQSJW	GO:0000155	1/119	phosphorelay sensor kinase activity	molecular_function	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
EOG8GQSJW	GO:0009950	1/119	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8GQSJW	GO:0045861	1/119	negative regulation of proteolysis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
EOG8GQSJW	GO:0035006	1/119	melanization defense response	biological_process	"The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809]
EOG8GQSJW	GO:0035009	1/119	negative regulation of melanization defense response	biological_process	"Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection." [GOC:bf, PMID:12408809]
EOG8GQSJW	GO:0004867	1/119	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG8GQSJW	GO:0016020	1/119	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8GQSJW	GO:0050832	1/119	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8F4VR3	GO:0004386	8/71	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8F4VR3	GO:0005524	6/71	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8F4VR3	GO:0046872	5/71	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8F4VR3	GO:0017111	4/71	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8F4VR3	GO:0003677	1/71	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CVJP6	GO:0016758	34/154	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG81VNHK	GO:0005634	1/143	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RBT15	GO:0004616	27/92	phosphogluconate dehydrogenase (decarboxylating) activity	molecular_function	"Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44]
EOG8RBT15	GO:0006098	27/92	pentose-phosphate shunt	biological_process	"The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]
EOG8RBT15	GO:0008442	24/92	3-hydroxyisobutyrate dehydrogenase activity	molecular_function	"Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+." [EC:1.1.1.31]
EOG8RBT15	GO:0051287	21/92	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8RBT15	GO:0006573	18/92	valine metabolic process	biological_process	"The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." [GOC:ai]
EOG8RBT15	GO:0050662	4/92	coenzyme binding	molecular_function	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
EOG8RBT15	GO:0016616	2/92	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8RBT15	GO:0005739	1/92	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8RBT15	GO:0005811	1/92	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8RBT15	GO:0006574	1/92	valine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid." [GOC:ai]
EOG81VNH1	GO:0016021	1/46	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81VNH6	GO:0016286	30/107	small conductance calcium-activated potassium channel activity	molecular_function	"Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754]
EOG81VNH6	GO:0016021	30/107	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81VNH6	GO:0005886	1/107	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG81VNH6	GO:0043025	1/107	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG81VNH6	GO:0006813	1/107	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG81VNH6	GO:0009881	1/107	photoreceptor activity	molecular_function	"The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators]
EOG81VNH6	GO:0007165	1/107	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG81VNH6	GO:0071805	1/107	potassium ion transmembrane transport	biological_process	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
EOG81VNH6	GO:0005516	1/107	calmodulin binding	molecular_function	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
EOG81VNH6	GO:0016057	1/107	regulation of membrane potential in photoreceptor cell	biological_process	"Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb]
EOG82FVZ7	GO:0003755	26/72	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG82FVZ7	GO:0006457	26/72	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG82FVZ7	GO:0017176	2/72	phosphatidylinositol N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]
EOG82FVZ7	GO:0016021	2/72	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82FVZ7	GO:0006506	2/72	GPI anchor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
EOG82FVZ7	GO:0071011	1/72	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG82FVZ7	GO:0016853	1/72	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG82FVZ7	GO:0071013	1/72	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG82FVZ7	GO:0000398	1/72	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG80CKX6	GO:0016021	222/694	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80CKX6	GO:0003333	7/694	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG80CKX6	GO:0015171	7/694	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG80CKX6	GO:0040007	2/694	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG80CKX6	GO:0044719	1/694	regulation of imaginal disc-derived wing size	biological_process	"Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
EOG80CKX6	GO:0022008	1/694	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG80CKX7	GO:0007165	26/89	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG80CKX7	GO:0005622	26/89	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG80CKX7	GO:0005515	1/89	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG80CKX7	GO:0005096	1/89	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG80CKX7	GO:0017160	1/89	Ral GTPase binding	molecular_function	"Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG80CKX7	GO:0007275	1/89	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG80CKX7	GO:0006898	1/89	receptor-mediated endocytosis	biological_process	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
EOG80CKX7	GO:0046578	1/89	regulation of Ras protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
EOG8Q2GWW	GO:0032994	1/143	protein-lipid complex	cellular_component	"A macromolecular complex containing separate protein and lipid molecules.  Separate in this context means not covalently bound to each other." [GOC:mah]
EOG8Q2GWW	GO:0006869	1/143	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG8Q2GWW	GO:0006642	1/143	triglyceride mobilization	biological_process	"The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625]
EOG8Q2GWW	GO:0005737	1/143	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Q2GWW	GO:0010898	1/143	positive regulation of triglyceride catabolic process	biological_process	"Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb]
EOG8Q2GWW	GO:0005811	1/143	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8Q2GWW	GO:0034389	1/143	lipid particle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201]
EOG8Q2GWW	GO:1990044	1/143	protein localization to lipid particle	biological_process	"A process in which a protein is transported to, or maintained in, a location on or within a lipid particle." [GOC:sart, PMID:22505614]
EOG8Q2GWW	GO:0022008	1/143	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8Q2GWW	GO:0019915	1/143	lipid storage	biological_process	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]
EOG8Q2GWW	GO:0010883	1/143	regulation of lipid storage	biological_process	"Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
EOG8FR36F	GO:0016301	1/92	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG84QWGG	GO:0003677	13/47	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84QWGG	GO:0003676	4/47	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84QWGG	GO:0046872	2/47	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84QWGK	GO:0042302	90/953	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG84QWGK	GO:0032784	4/953	regulation of DNA-templated transcription, elongation	biological_process	"Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]
EOG84QWGK	GO:0031012	4/953	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG84QWGK	GO:0006357	4/953	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG84QWGK	GO:0008010	3/953	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG84QWGK	GO:0040003	3/953	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG84QWGK	GO:0005576	2/953	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG84QWGK	GO:0003677	2/953	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84QWGK	GO:0008061	2/953	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG84QWGK	GO:0006334	1/953	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG84QWGK	GO:0022008	1/953	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84QWGK	GO:0003676	1/953	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84QWGK	GO:0030023	1/953	extracellular matrix constituent conferring elasticity	molecular_function	"A component of the extracellular matrix that enables the matrix to recoil after transient stretching." [GOC:mah, ISBN:0815316194]
EOG84QWGK	GO:0005737	1/953	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84QWGK	GO:0000786	1/953	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG84QWGK	GO:0016874	1/953	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG84QWGK	GO:0018149	1/953	peptide cross-linking	biological_process	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]
EOG84QWGK	GO:0005201	1/953	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG84QWGK	GO:0005634	1/953	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84QWGK	GO:0006030	1/953	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG84QWGK	GO:0032992	1/953	protein-carbohydrate complex	cellular_component	"A macromolecular complex containing separate protein and carbohydrate molecules.  Separate in this context means not covalently bound to each other." [GOC:mah]
EOG866Z1C	GO:0008270	26/120	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG866Z1C	GO:0048813	1/120	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG866Z1C	GO:0007517	1/120	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG866Z1C	GO:0046872	1/120	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG866Z1C	GO:0006909	1/120	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8CG2Q4	GO:0008270	25/84	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CG2Q4	GO:0016021	1/84	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QFZV3	GO:0005975	201/525	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8QFZV3	GO:0043169	199/525	cation binding	molecular_function	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]
EOG8QFZV3	GO:0003824	188/525	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8QFZV3	GO:0032450	12/525	maltose alpha-glucosidase activity	molecular_function	"Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141]
EOG8QFZV3	GO:0016740	1/525	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8QFZV3	GO:0003677	1/525	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8VHNNQ	GO:0007264	1/35	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8VHNNQ	GO:0005525	1/35	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8TB6RT	GO:0097372	28/97	NAD-dependent histone deacetylase activity (H3-K18 specific)	molecular_function	"Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein." [EC:3.5.1.17, GOC:sp, PMID:22722849, RHEA:24551]
EOG8TB6RT	GO:0006355	28/97	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8TB6RT	GO:0005634	28/97	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TB6RT	GO:0046969	28/97	NAD-dependent histone deacetylase activity (H3-K9 specific)	molecular_function	"Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [EC:3.5.1.17, RHEA:24551]
EOG8TB6RT	GO:0006351	28/97	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8TB6RT	GO:0046970	28/97	NAD-dependent histone deacetylase activity (H4-K16 specific)	molecular_function	"Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [EC:3.5.1.17, GOC:vw, RHEA:24551]
EOG8TB6RT	GO:0032041	28/97	NAD-dependent histone deacetylase activity (H3-K14 specific)	molecular_function	"Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [EC:3.5.1.17, RHEA:24551]
EOG8TB6RT	GO:0004407	3/97	histone deacetylase activity	molecular_function	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.98, PMID:9893272]
EOG8TB6RT	GO:0035098	1/97	ESC/E(Z) complex	cellular_component	"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]
EOG8TB6RT	GO:0048477	1/97	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8TB6RT	GO:0016458	1/97	gene silencing	biological_process	"Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb]
EOG8TB6RT	GO:0007350	1/97	blastoderm segmentation	biological_process	"The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8TB6RT	GO:0008134	1/97	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8TB6RT	GO:0048813	1/97	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8TB6RT	GO:0045892	1/97	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8TB6RT	GO:0003714	1/97	transcription corepressor activity	molecular_function	"Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8TB6RT	GO:0070983	1/97	dendrite guidance	biological_process	"The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
EOG8TB6RT	GO:0000118	1/97	histone deacetylase complex	cellular_component	"A protein complex that possesses histone deacetylase activity." [GOC:mah]
EOG8TB6RT	GO:0005737	1/97	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8TB6RT	GO:0031523	1/97	Myb complex	cellular_component	"A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624]
EOG8TB6RT	GO:0007517	1/97	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8TB6RT	GO:0000785	1/97	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG8TB6RT	GO:0070822	1/97	Sin3-type complex	cellular_component	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]
EOG8TB6RT	GO:0008340	1/97	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8TB6RT	GO:0006099	1/97	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8TB6RT	GO:0017053	1/97	transcriptional repressor complex	cellular_component	"A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah]
EOG8TB6RT	GO:0000122	1/97	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8TB6RT	GO:0016575	1/97	histone deacetylation	biological_process	"The modification of histones by removal of acetyl groups." [GOC:ai]
EOG8TB6RT	GO:0006342	1/97	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG8TB6RT	GO:0022904	1/97	respiratory electron transport chain	biological_process	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]
EOG8TB6RT	GO:0005515	1/97	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8TB6RT	GO:0016787	1/97	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8TB6RT	GO:0005705	1/97	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG8TB6RT	GO:0022008	1/97	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8TB6RT	GO:0016568	1/97	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG8TB6RT	GO:0016581	1/97	NuRD complex	cellular_component	"An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569]
EOG8TB6RT	GO:2001229	1/97	negative regulation of response to gamma radiation	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation." [GOC:obol]
EOG8TB6RT	GO:0005700	1/97	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8TB6RT	GO:0016580	1/97	Sin3 complex	cellular_component	"A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins." [PMID:10589671, PMID:11743021, PMID:12865422]
EOG8TB6RT	GO:0050771	1/97	negative regulation of axonogenesis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis." [GOC:ai]
EOG83JFMQ	GO:0035556	27/78	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG83JFMQ	GO:0016020	25/78	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG83JFMQ	GO:0015031	2/78	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG83JFMQ	GO:0005789	2/78	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG83JFMQ	GO:0006888	2/78	ER to Golgi vesicle-mediated transport	biological_process	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]
EOG83JFMQ	GO:0016021	2/78	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83JFMQ	GO:0007275	1/78	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG83JFMQ	GO:0007310	1/78	oocyte dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG83JFMQ	GO:0009952	1/78	anterior/posterior pattern specification	biological_process	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG83JFMQ	GO:0046843	1/78	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG83JFMQ	GO:0007314	1/78	oocyte anterior/posterior axis specification	biological_process	"Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG83JFMQ	GO:0008314	1/78	gurken signaling pathway	biological_process	"The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to the ligand Gurken." [GOC:bf, PMID:23972992]
EOG83JFMQ	GO:0030722	1/78	establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification	biological_process	"The directed movement of the nucleus to a specific location within the cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte. In the insect oocyte, for example, the nucleus is repositioned to a dorso-anterior position." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb]
EOG83JFMQ	GO:0016192	1/78	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG83JFMQ	GO:0009953	1/78	dorsal/ventral pattern formation	biological_process	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG83JFMQ	GO:0008298	1/78	intracellular mRNA localization	biological_process	"Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai]
EOG83JFMQ	GO:0045450	1/78	bicoid mRNA localization	biological_process	"Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators]
EOG83JFMQ	GO:0005515	1/78	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG83JFMQ	GO:0045451	1/78	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG83JFMQ	GO:0007350	1/78	blastoderm segmentation	biological_process	"The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8FFGG3	GO:0007165	110/271	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8FFGG3	GO:0016021	58/271	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FFGG3	GO:0000281	2/271	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8FFGG3	GO:0045087	2/271	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8FFGG3	GO:0006967	2/271	positive regulation of antifungal peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah]
EOG8FFGG3	GO:0008063	2/271	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8FFGG3	GO:0004721	2/271	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8FFGG3	GO:0009620	1/271	response to fungus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
EOG8FFGG3	GO:0009880	1/271	embryonic pattern specification	biological_process	"The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
EOG8FFGG3	GO:0007352	1/271	zygotic specification of dorsal/ventral axis	biological_process	"The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf]
EOG8FFGG3	GO:0005737	1/271	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8FFGG3	GO:0016201	1/271	synaptic target inhibition	biological_process	"The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]
EOG8FFGG3	GO:0019732	1/271	antifungal humoral response	biological_process	"An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8FFGG3	GO:0019730	1/271	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG8FFGG3	GO:0015026	1/271	coreceptor activity	molecular_function	"Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators]
EOG8FFGG3	GO:0019901	1/271	protein kinase binding	molecular_function	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]
EOG8FFGG3	GO:0003676	1/271	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FFGG3	GO:0051536	1/271	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8FFGG3	GO:0050832	1/271	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8FFGG3	GO:0004888	1/271	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8FFGG3	GO:0043234	1/271	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8FFGG3	GO:0045610	1/271	regulation of hemocyte differentiation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG8FFGG3	GO:0070976	1/271	TIR domain binding	molecular_function	"Interacting selectively and non-covalently with a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]
EOG8FFGG3	GO:0009950	1/271	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8FFGG3	GO:0007416	1/271	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG8FFGG3	GO:0035172	1/271	hemocyte proliferation	biological_process	"The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG8FFGG3	GO:0019955	1/271	cytokine binding	molecular_function	"Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471]
EOG8FFGG3	GO:0007155	1/271	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8FFGG3	GO:0007507	1/271	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8FFGG3	GO:0005769	1/271	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG8FFGG3	GO:0006963	1/271	positive regulation of antibacterial peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475]
EOG8FFGG3	GO:0005515	1/271	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FFGG3	GO:0002807	1/271	positive regulation of antimicrobial peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
EOG8FFGG3	GO:0009897	1/271	external side of plasma membrane	cellular_component	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]
EOG8FFGG3	GO:0042802	1/271	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG8FFGG3	GO:0005121	1/271	Toll binding	molecular_function	"Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb]
EOG8FFGG3	GO:0050830	1/271	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG8FFGG3	GO:0006952	1/271	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8FFGG3	GO:0030097	1/271	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG8FFGG3	GO:0005886	1/271	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8FFGG3	GO:0009617	1/271	response to bacterium	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]
EOG8FFGG3	GO:0008270	1/271	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FFGG3	GO:0002121	1/271	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8FFGG3	GO:0006955	1/271	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG86DPGH	GO:0005856	22/147	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG86DPGH	GO:0005089	18/147	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG86DPGH	GO:0019898	13/147	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG86DPGH	GO:0005737	13/147	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86DPGH	GO:0008092	1/147	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8T4G89	GO:0005524	26/94	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8T4G89	GO:0006457	25/94	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8T4G89	GO:0005737	25/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8T4G89	GO:0005875	1/94	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8T4G89	GO:0007052	1/94	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8T4G89	GO:0031122	1/94	cytoplasmic microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
EOG8T4G89	GO:0044267	1/94	cellular protein metabolic process	biological_process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]
EOG8T4G89	GO:0016887	1/94	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8T4G89	GO:0022008	1/94	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG80VZ5C	GO:0010468	1/84	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8K6JJ1	GO:0046872	6/37	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8T4G8H	GO:0017022	1/89	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8NKF9R	GO:0003676	1/81	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NKF9R	GO:0008270	1/81	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8HB12K	GO:0003676	5/387	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HB12K	GO:0003723	1/387	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8HB12K	GO:0003964	1/387	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8HB12K	GO:0004842	1/387	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8T4G8V	GO:0018095	38/135	protein polyglutamylation	biological_process	"The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid." [RESID:AA0202]
EOG8T4G8V	GO:0004835	3/135	tubulin-tyrosine ligase activity	molecular_function	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]
EOG8T4G8V	GO:0042060	1/135	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8T4G8V	GO:0022008	1/135	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8HB12C	GO:0005700	1/145	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8HB12C	GO:0044666	1/145	MLL3/4 complex	cellular_component	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]
EOG8HB12C	GO:0071557	1/145	histone H3-K27 demethylation	biological_process	"The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone." [GOC:sp, PMID:20023638]
EOG8HB12C	GO:0045746	1/145	negative regulation of Notch signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8HB12C	GO:1902465	1/145	negative regulation of histone H3-K27 trimethylation	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745]
EOG8HB12C	GO:0061086	1/145	negative regulation of histone H3-K27 methylation	biological_process	"Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb]
EOG8HB12C	GO:0042060	1/145	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8HB12C	GO:0045893	1/145	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8HB12C	GO:0045498	1/145	sex comb development	biological_process	"The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk]
EOG8HB12C	GO:0005705	1/145	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG8HB12C	GO:1990248	1/145	regulation of transcription from RNA polymerase II promoter in response to DNA damage	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:15660129]
EOG8HB12C	GO:0008168	1/145	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8HB12C	GO:0008285	1/145	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8HB12C	GO:0071390	1/145	cellular response to ecdysone	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah]
EOG8HB12C	GO:0035078	1/145	induction of programmed cell death by ecdysone	biological_process	"Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death." [GOC:bf]
EOG8HB12C	GO:0005515	1/145	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8HB12C	GO:0005634	1/145	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HB12C	GO:0016577	1/145	histone demethylation	biological_process	"The modification of histones by removal of methyl groups." [GOC:ai]
EOG8HB12C	GO:0010508	1/145	positive regulation of autophagy	biological_process	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8HB12C	GO:0001047	1/145	core promoter binding	molecular_function	"Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH]
EOG8HB12C	GO:0071480	1/145	cellular response to gamma radiation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah]
EOG8HB12C	GO:0051568	1/145	histone H3-K4 methylation	biological_process	"The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai]
EOG8HB12C	GO:0035072	1/145	ecdysone-mediated induction of salivary gland cell autophagic cell death	biological_process	"Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis." [GOC:bf]
EOG8W10T3	GO:0004222	1/49	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8Q87C2	GO:0006457	49/131	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8Q87C2	GO:0009408	1/131	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8Q87C2	GO:0005875	1/131	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8Q87C2	GO:0005737	1/131	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8QFZVS	GO:0005814	1/86	centriole	cellular_component	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
EOG8QFZVS	GO:0007099	1/86	centriole replication	biological_process	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194]
EOG8H1D99	GO:0004518	1/250	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8H1D99	GO:0004812	1/250	aminoacyl-tRNA ligase activity	molecular_function	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
EOG8H1D99	GO:0003677	1/250	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG866Z14	GO:0005886	2/23	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG866Z14	GO:0005509	2/23	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG866Z14	GO:0007156	2/23	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG866Z14	GO:0016021	2/23	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WSZTV	GO:0022008	1/75	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8WSZTV	GO:0005515	1/75	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8J13QM	GO:0016226	25/78	iron-sulfur cluster assembly	biological_process	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]
EOG8J13QM	GO:0008199	25/78	ferric iron binding	molecular_function	"Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai]
EOG8J13QM	GO:0005739	24/78	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8J13QM	GO:0004322	24/78	ferroxidase activity	molecular_function	"Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1]
EOG8J13QM	GO:0006879	1/78	cellular iron ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah]
EOG8J13QM	GO:0051881	1/78	regulation of mitochondrial membrane potential	biological_process	"Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai]
EOG8J13QM	GO:0019896	1/78	axon transport of mitochondrion	biological_process	"The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai]
EOG8J13QM	GO:0042542	1/78	response to hydrogen peroxide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]
EOG8J13QM	GO:0006783	1/78	heme biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl]
EOG8J13QM	GO:0045823	1/78	positive regulation of heart contraction	biological_process	"Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators]
EOG8J13QM	GO:0034986	1/78	iron chaperone activity	molecular_function	"Assists in the delivery of iron ions to target proteins or compartments." [GOC:BHF, GOC:vk]
EOG8J13QM	GO:0006811	1/78	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG876NFV	GO:0016881	23/88	acid-amino acid ligase activity	molecular_function	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
EOG876NFV	GO:0004842	3/88	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG876NFV	GO:0051299	1/88	centrosome separation	biological_process	"The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai]
EOG876NFV	GO:0051297	1/88	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG876NFV	GO:0043518	1/88	negative regulation of DNA damage response, signal transduction by p53 class mediator	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]
EOG876NFV	GO:0005737	1/88	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG876NFV	GO:0019904	1/88	protein domain specific binding	molecular_function	"Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators]
EOG876NFV	GO:0007052	1/88	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG876NFV	GO:0006281	1/88	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG876NFV	GO:1902166	1/88	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541]
EOG876NFV	GO:0002039	1/88	p53 binding	molecular_function	"Interacting selectively and non-covalently with one of the p53 family of proteins." [GOC:hjd]
EOG876NFV	GO:0042787	1/88	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological_process	"The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]
EOG876NFV	GO:0005524	1/88	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG876NFV	GO:0000422	1/88	mitophagy	biological_process	"The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]
EOG876NFV	GO:0032436	1/88	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	biological_process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]
EOG876NFV	GO:0032456	1/88	endocytic recycling	biological_process	"The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635]
EOG876NFV	GO:0005634	1/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG876NFT	GO:0003676	52/239	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG876NFT	GO:0046872	1/239	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG876NFT	GO:0005634	1/239	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG876NFT	GO:0003677	1/239	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG876NFP	GO:0005509	2/29	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG876NFN	GO:0006364	22/90	rRNA processing	biological_process	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
EOG85TG3J	GO:0046872	4/71	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG876NFH	GO:0004527	3/56	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8J13QS	GO:0016020	24/86	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8J13QS	GO:0016021	2/86	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J13QR	GO:0003677	3/96	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8J13QR	GO:0008080	2/96	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG8NCPT8	GO:0015018	43/138	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135]
EOG8NCPT8	GO:0016020	41/138	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NCPT8	GO:0030166	2/138	proteoglycan biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]
EOG8NCPT8	GO:0006688	2/138	glycosphingolipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators]
EOG8NCPT8	GO:0016021	2/138	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NCPT8	GO:0046987	2/138	N-acetyllactosamine beta-1,3-glucuronosyltransferase activity	molecular_function	"Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)." [GOC:bf, PMID:12511570]
EOG8NCPT8	GO:0046872	2/138	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NCPT8	GO:0046988	2/138	asioloorosomucoid beta-1,3-glucuronosyltransferase activity	molecular_function	"Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid." [GOC:bf, PMID:12511570]
EOG8NCPT8	GO:0000139	2/138	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8NCPT8	GO:0009101	2/138	glycoprotein biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]
EOG8NCPT8	GO:0046989	2/138	galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity	molecular_function	"Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids." [GOC:bf, PMID:12511570]
EOG8NCPT8	GO:0006486	2/138	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8NCPT8	GO:0007422	1/138	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8X3KG1	GO:0043565	75/346	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8X3KG1	GO:0008270	75/346	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X3KG1	GO:0003700	74/346	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8X3KG1	GO:0005634	6/346	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X3KG1	GO:0006351	4/346	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8X3KG1	GO:0003707	3/346	steroid hormone receptor activity	molecular_function	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
EOG8X3KG1	GO:0006366	2/346	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8X3KG1	GO:0000981	2/346	RNA polymerase II transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
EOG8X3KG1	GO:0006357	1/346	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8X3KG1	GO:0001103	1/346	RNA polymerase II repressing transcription factor binding	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription." [GOC:txnOH]
EOG8X3KG1	GO:0030154	1/346	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8X3KG1	GO:0046982	1/346	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8X3KG1	GO:0005515	1/346	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8X3KG1	GO:0000122	1/346	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8X3KG1	GO:0061320	1/346	pericardial nephrocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]
EOG8X3KG1	GO:0060047	1/346	heart contraction	biological_process	"The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph]
EOG8X3KG1	GO:0007507	1/346	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8X3KG1	GO:0035050	1/346	embryonic heart tube development	biological_process	"The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
EOG8X3KG1	GO:0045944	1/346	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8X3KG1	GO:0001085	1/346	RNA polymerase II transcription factor binding	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II." [GOC:txnOH]
EOG8X3KG1	GO:0045893	1/346	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8X3KG1	GO:0009888	1/346	tissue development	biological_process	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]
EOG8X3KG1	GO:0035051	1/346	cardiocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf]
EOG8X3KG1	GO:0007398	1/346	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG8X3KG1	GO:0007389	1/346	pattern specification process	biological_process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
EOG8X3KG1	GO:0007350	1/346	blastoderm segmentation	biological_process	"The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8X3KG1	GO:0045892	1/346	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8X3KG1	GO:0048542	1/346	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG8X3KG1	GO:0022416	1/346	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8X3KG1	GO:0007510	1/346	cardioblast cell fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG8X3KG1	GO:0000983	1/346	transcription factor activity, RNA polymerase II core promoter sequence-specific	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
EOG8X3KG1	GO:0008407	1/346	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG8X3KG1	GO:0002805	1/346	regulation of antimicrobial peptide biosynthetic process	biological_process	"Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
EOG8X3KG1	GO:0009887	1/346	organ morphogenesis	biological_process	"Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]
EOG8X3KG1	GO:0007391	1/346	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8X3KG1	GO:0007179	1/346	transforming growth factor beta receptor signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
EOG8X3KG1	GO:0042440	1/346	pigment metabolic process	biological_process	"The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732]
EOG8X3KG1	GO:0008045	1/346	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8X3KG1	GO:0010002	1/346	cardioblast differentiation	biological_process	"The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG8KSS1K	GO:0003676	2/189	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KSS1K	GO:0015074	1/189	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG89GNXP	GO:0000387	24/85	spliceosomal snRNP assembly	biological_process	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG89GNXP	GO:0005681	24/85	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG89GNXP	GO:0000245	5/85	spliceosomal complex assembly	biological_process	"The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]
EOG89GNXP	GO:0034730	1/85	SmD-containing SMN-Sm protein complex	cellular_component	"An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex." [PMID:12975319, PMID:17401408]
EOG89GNXP	GO:0008344	1/85	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG89GNXP	GO:0007629	1/85	flight behavior	biological_process	"The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
EOG89GNXP	GO:0071254	1/85	cytoplasmic U snRNP body	cellular_component	"A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295]
EOG89GNXP	GO:0034718	1/85	SMN-Gemin2 complex	cellular_component	"A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex." [GOC:mah, PMID:17640873]
EOG8ZGRST	GO:0045454	33/123	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8ZGRST	GO:0009055	33/123	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8ZGRST	GO:0015035	33/123	protein disulfide oxidoreductase activity	molecular_function	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]
EOG8ZGRST	GO:0046872	1/123	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89GNXV	GO:0003677	14/121	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG89GNXV	GO:0003899	14/121	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG89GNXV	GO:0006351	14/121	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8KSS18	GO:0005509	2/63	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8NCPTT	GO:0003676	13/210	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NCPTT	GO:0003677	8/210	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NCPTT	GO:0003964	1/210	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8NCPTT	GO:0003723	1/210	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8HQH0J	GO:0003964	1/49	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8ZGRSJ	GO:0018342	27/88	protein prenylation	biological_process	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]
EOG8ZGRSJ	GO:0008318	21/88	protein prenyltransferase activity	molecular_function	"Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah]
EOG8ZGRSJ	GO:0004663	6/88	Rab geranylgeranyltransferase activity	molecular_function	"Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375]
EOG8ZGRSJ	GO:0008360	1/88	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8ZGRSJ	GO:0022008	1/88	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8ZGRSJ	GO:0007155	1/88	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8ZGRSJ	GO:0008270	1/88	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X3KGX	GO:0016021	26/90	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X3KGZ	GO:0008484	2/12	sulfuric ester hydrolase activity	molecular_function	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]
EOG8ZGRT9	GO:0019013	1/92	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8ZGRT9	GO:0030529	1/92	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8ZGRT9	GO:0016905	1/92	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG8KD92J	GO:0003824	2/167	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8KD92J	GO:0019898	1/167	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8KD92J	GO:0007561	1/167	imaginal disc eversion	biological_process	"The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317]
EOG85TG33	GO:0016021	49/151	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85TG33	GO:0006810	39/151	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG85TG33	GO:0006839	10/151	mitochondrial transport	biological_process	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]
EOG85TG33	GO:0031966	10/151	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG85TG33	GO:0005811	1/151	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG85TG33	GO:0005739	1/151	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG870X09	GO:0003676	1/73	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BP3TS	GO:0016020	21/71	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8B0150	GO:0047057	2/89	vitamin-K-epoxide reductase (warfarin-sensitive) activity	molecular_function	"Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.1, MetaCyc:1.1.4.1-RXN]
EOG8QZB2Z	GO:0005739	3/87	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8QZB2Z	GO:0032543	2/87	mitochondrial translation	biological_process	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]
EOG8QZB2Z	GO:0070681	2/87	glutaminyl-tRNAGln biosynthesis via transamidation	biological_process	"A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921]
EOG8QZB2Z	GO:0030956	2/87	glutamyl-tRNA(Gln) amidotransferase complex	cellular_component	"A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg]
EOG8QZB2Z	GO:0006450	2/87	regulation of translational fidelity	biological_process	"Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]
EOG8QZB2Z	GO:0003887	2/87	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8QZB2Z	GO:0050567	2/87	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	molecular_function	"Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN]
EOG8QZB2Z	GO:0005524	2/87	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QZB2Z	GO:0006264	1/87	mitochondrial DNA replication	biological_process	"The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai]
EOG8QZB2Z	GO:0005515	1/87	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QZB2Z	GO:0000002	1/87	mitochondrial genome maintenance	biological_process	"The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw]
EOG8QZB2Z	GO:0005760	1/87	gamma DNA polymerase complex	cellular_component	"A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093]
EOG8QZB2Z	GO:0006261	1/87	DNA-dependent DNA replication	biological_process	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]
EOG8QZB2Z	GO:0004812	1/87	aminoacyl-tRNA ligase activity	molecular_function	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
EOG8QZB2Z	GO:0007005	1/87	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8BP3TH	GO:0004190	2/20	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG869TB8	GO:0022008	1/80	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8BS026	GO:0007156	1/35	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8BS026	GO:0005509	1/35	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8BS026	GO:0005886	1/35	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8STVJT	GO:0006810	1/58	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8STVJT	GO:0005622	1/58	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8STVJT	GO:0051028	1/58	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8STVJT	GO:0005634	1/58	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8QRKHV	GO:0008484	24/109	sulfuric ester hydrolase activity	molecular_function	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]
EOG8QRKHV	GO:0008449	2/109	N-acetylglucosamine-6-sulfatase activity	molecular_function	"Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14]
EOG8QRKHV	GO:0005795	1/109	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG8QRKHV	GO:0008045	1/109	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8QRKHV	GO:0016201	1/109	synaptic target inhibition	biological_process	"The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]
EOG8QRKHV	GO:0005783	1/109	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8QRKHV	GO:0045879	1/109	negative regulation of smoothened signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG8QRKHV	GO:0030111	1/109	regulation of Wnt signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]
EOG8QRKHV	GO:0017015	1/109	regulation of transforming growth factor beta receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah]
EOG8QRKHV	GO:0046872	1/109	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QRKHV	GO:0009986	1/109	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8QRKHV	GO:0045880	1/109	positive regulation of smoothened signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG8QRKHV	GO:0042059	1/109	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8XD660	GO:0016787	32/178	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8XD660	GO:0006044	28/178	N-acetylglucosamine metabolic process	biological_process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
EOG8XD660	GO:0004342	28/178	glucosamine-6-phosphate deaminase activity	molecular_function	"Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+)." [EC:3.5.99.6, RHEA:12175]
EOG8XD660	GO:0005975	27/178	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8XD660	GO:0006043	4/178	glucosamine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732]
EOG8XD660	GO:0005737	4/178	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XD660	GO:0006091	4/178	generation of precursor metabolites and energy	biological_process	"The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]
EOG8XD660	GO:0051301	2/178	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8XD660	GO:0016021	1/178	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XD660	GO:0004527	1/178	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8XD660	GO:0046872	1/178	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83FKCR	GO:0016787	21/85	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG83FKCR	GO:0052846	3/85	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity	molecular_function	"Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+." [MetaCyc:RXN-10965, PMID:10827188, PMID:11502751]
EOG83FKCR	GO:0052843	3/85	inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity	molecular_function	"Catalysis of the reaction: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+." [MetaCyc:RXN-10977, PMID:10827188, PMID:11502751]
EOG83FKCR	GO:0052848	3/85	inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity	molecular_function	"Catalysis of the reaction: 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + H+." [MetaCyc:RXN-10976, PMID:10827188, PMID:11502751]
EOG83FKCR	GO:0008486	3/85	diphosphoinositol-polyphosphate diphosphatase activity	molecular_function	"Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate." [EC:3.6.1.52]
EOG83FKCR	GO:0052844	3/85	inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity	molecular_function	"Catalysis of the reaction: inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+." [MetaCyc:RXN-10978, PMID:10827188, PMID:11502751]
EOG83FKCR	GO:0052847	3/85	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity	molecular_function	"Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+." [MetaCyc:RXN-10975, PMID:10827188, PMID:11502751]
EOG83FKCR	GO:0052840	3/85	inositol diphosphate tetrakisphosphate diphosphatase activity	molecular_function	"Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate." [MetaCyc:RXN-10963, PMID:10827188, PMID:11502751]
EOG83FKCR	GO:0052845	3/85	inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity	molecular_function	"Catalysis of the reaction: inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+." [MetaCyc:RXN-10964, PMID:10827188, PMID:11502751]
EOG83FKCR	GO:0009117	1/85	nucleotide metabolic process	biological_process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]
EOG83FKCR	GO:0005737	1/85	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83FKCR	GO:0043647	1/85	inositol phosphate metabolic process	biological_process	"The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, GOC:jl]
EOG83FKCR	GO:0005634	1/85	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XD66J	GO:0016021	27/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XD66J	GO:0055085	26/91	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8XD66J	GO:0005743	6/91	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8XD66J	GO:0006810	1/91	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8XD66J	GO:0050829	1/91	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8XD66J	GO:0045089	1/91	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8TMTJ4	GO:0005901	9/42	caveola	cellular_component	"A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include any of the minute pits or incuppings of the cell membrane formed during pinocytosis. Such caveolae may be pinched off to form free vesicles within the cytoplasm." [GOC:mah, ISBN:0721662544, PMID:16645198]
EOG8TMTJ4	GO:0000139	9/42	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8TMTJ4	GO:0005794	2/42	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8TMTJ4	GO:0005886	2/42	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG87H867	GO:0003723	6/322	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG87H867	GO:0003964	6/322	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8XH2F4	GO:0016021	22/77	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XH2F4	GO:0004930	20/77	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8XH2F4	GO:0007186	1/77	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8XH2F4	GO:0008188	1/77	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8XH2F4	GO:0004983	1/77	neuropeptide Y receptor activity	molecular_function	"Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
EOG8XH2F4	GO:0007218	1/77	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8ZKN1X	GO:0006807	72/199	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG8ZKN1X	GO:0016811	72/199	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]
EOG8ZKN1X	GO:0004435	2/199	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8ZKN1X	GO:0035556	2/199	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8ZKN1X	GO:0006629	2/199	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8ZKN1X	GO:0071110	1/199	histone biotinylation	biological_process	"The modification of a histone by the addition of a biotinyl group." [GOC:rph, PMID:14613969, PMID:19019041]
EOG8ZKN1X	GO:0019898	1/199	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8ZKN1X	GO:0016787	1/199	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8ZKN1X	GO:0009408	1/199	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8ZKN1X	GO:0017159	1/199	pantetheine hydrolase activity	molecular_function	"Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine." [EC:3.5.1.92, RHEA:13448]
EOG8ZKN1X	GO:0018054	1/199	peptidyl-lysine biotinylation	biological_process	"The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117]
EOG89GNWT	GO:0016779	1/11	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG89GNWT	GO:0003924	1/11	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG89GNWT	GO:0005525	1/11	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG89GNWT	GO:0005622	1/11	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG89GNWT	GO:0003746	1/11	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG8XPSVT	GO:0004222	3/45	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG84F8R3	GO:0016888	24/83	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	molecular_function	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
EOG84F8R3	GO:0005737	1/83	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84F8R3	GO:0006309	1/83	apoptotic DNA fragmentation	biological_process	"The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520]
EOG84F8R3	GO:0004536	1/83	deoxyribonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684]
EOG84F8R3	GO:0005634	1/83	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88D38W	GO:0016788	294/950	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG88D38W	GO:0016042	262/950	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG88D38W	GO:0006629	148/950	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG88D38W	GO:0004806	8/950	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG88D38W	GO:0005615	5/950	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG88D38W	GO:0032504	5/950	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG88D38W	GO:0016298	4/950	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG88D38W	GO:0030246	1/950	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG88D38W	GO:0016787	1/950	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG88D38W	GO:0003676	1/950	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88D38W	GO:0007586	1/950	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG88D38W	GO:0042632	1/950	cholesterol homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]
EOG88D38W	GO:0006886	1/950	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG88D38W	GO:0048812	1/950	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG88D38W	GO:0016192	1/950	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG88D38W	GO:0005576	1/950	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG88D38W	GO:0030132	1/950	clathrin coat of coated pit	cellular_component	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]
EOG88D38W	GO:0030130	1/950	clathrin coat of trans-Golgi network vesicle	cellular_component	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]
EOG88D38W	GO:0005198	1/950	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG88D38W	GO:0031410	1/950	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG88D38W	GO:0070328	1/950	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG88D38W	GO:0004771	1/950	sterol esterase activity	molecular_function	"Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13]
EOG822D0C	GO:0008270	56/152	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG822D0C	GO:0016491	51/152	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG822D0C	GO:0003939	5/152	L-iditol 2-dehydrogenase activity	molecular_function	"Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14]
EOG8W6RC2	GO:0005622	2/21	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8W6RC2	GO:0005085	2/21	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8W6RC2	GO:0007264	2/21	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8BK7KT	GO:0008615	5/32	pyridoxine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds." [GOC:ai]
EOG8BK7KT	GO:0004733	5/32	pyridoxamine-phosphate oxidase activity	molecular_function	"Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide." [EC:1.4.3.5]
EOG8BK7KT	GO:0010181	5/32	FMN binding	molecular_function	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]
EOG822D0T	GO:0008270	23/84	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG822D0T	GO:0046872	3/84	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG822D0T	GO:0005634	1/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG822D0T	GO:0030182	1/84	neuron differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
EOG822D0T	GO:0022008	1/84	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8616HZ	GO:0007155	51/345	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8616HZ	GO:0005524	32/345	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8616HZ	GO:0004672	17/345	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8616HZ	GO:0004713	14/345	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8616HZ	GO:0004714	7/345	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8616HZ	GO:0004715	1/345	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8616HZ	GO:0007169	1/345	transmembrane receptor protein tyrosine kinase signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
EOG8616HZ	GO:0006468	1/345	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8616HZ	GO:0018108	1/345	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG8616HZ	GO:0016020	1/345	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CNT6C	GO:0003964	574/3445	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8CNT6C	GO:0003723	549/3445	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CNT6C	GO:0008270	159/3445	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CNT6C	GO:0003676	89/3445	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CNT6C	GO:0004523	26/3445	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8CNT6C	GO:0005198	8/3445	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8CNT6C	GO:0005882	8/3445	intermediate filament	cellular_component	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
EOG8CNT6C	GO:0004519	5/3445	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8CNT6C	GO:0003677	5/3445	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CNT6C	GO:0046872	4/3445	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CNT6C	GO:0015074	4/3445	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8CNT6C	GO:0016021	3/3445	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CNT6C	GO:0004871	2/3445	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8CNT6C	GO:0000166	1/3445	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8CNT6C	GO:0006310	1/3445	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8CNT6C	GO:0004555	1/3445	alpha,alpha-trehalase activity	molecular_function	"Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28]
EOG8CNT6C	GO:0016874	1/3445	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8CNT6C	GO:0005991	1/3445	trehalose metabolic process	biological_process	"The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]
EOG8CNT6C	GO:0016881	1/3445	acid-amino acid ligase activity	molecular_function	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
EOG8CNT6C	GO:0016020	1/3445	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CNT6C	GO:0005549	1/3445	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8CNT6C	GO:0005622	1/3445	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8CNT6C	GO:0005215	1/3445	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8CNT6C	GO:0080019	1/3445	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8CNT6C	GO:0003887	1/3445	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8CNT6C	GO:0016787	1/3445	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8CNT6C	GO:0022857	1/3445	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8CNT6C	GO:0004984	1/3445	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8VMHZ7	GO:0016021	18/82	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VMHZ7	GO:0016020	6/82	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8VMHZ7	GO:0035208	1/82	positive regulation of hemocyte proliferation	biological_process	"Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG84TRQB	GO:0003735	26/92	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG84TRQB	GO:0005840	26/92	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG84TRQB	GO:0006412	26/92	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG84TRQB	GO:0019843	26/92	rRNA binding	molecular_function	"Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl]
EOG84TRQB	GO:0007052	1/92	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG84TRQB	GO:0000022	1/92	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG84TRQB	GO:0051298	1/92	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG85XBBC	GO:0003824	4/53	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG84F8RS	GO:0000339	28/84	RNA cap binding	molecular_function	"Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule." [GOC:krc]
EOG84F8RS	GO:0005846	28/84	nuclear cap binding complex	cellular_component	"A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export." [PMID:16043498]
EOG84F8RS	GO:0045292	28/84	mRNA cis splicing, via spliceosome	biological_process	"The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, http://calspace.ucsd.edu/origins/Glossary/C.htm, ISBN:0879695897]
EOG84F8RS	GO:0000166	28/84	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG84F8RS	GO:0005634	17/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84F8RS	GO:0006370	17/84	7-methylguanosine mRNA capping	biological_process	"Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685]
EOG84F8RS	GO:0031047	16/84	gene silencing by RNA	biological_process	"Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054]
EOG84F8RS	GO:0000398	1/84	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG84F8RS	GO:0071013	1/84	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG84F8RS	GO:0005681	1/84	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG84F8RS	GO:0003729	1/84	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG84F8RS	GO:0016246	1/84	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG84F8RS	GO:0045071	1/84	negative regulation of viral genome replication	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication." [GOC:go_curators]
EOG84F8RS	GO:0035195	1/84	gene silencing by miRNA	biological_process	"Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortgening and subsequent degredation of the mRNA." [PMID:14744438, PMID:15066275, PMID:15066283, PMID:23209154]
EOG84F8RS	GO:0005875	1/84	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG84F8RS	GO:0005515	1/84	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG84F8RS	GO:0031053	1/84	primary miRNA processing	biological_process	"Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354]
EOG84F8RS	GO:0071011	1/84	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG84F8RS	GO:0030422	1/84	production of siRNA involved in RNA interference	biological_process	"Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674]
EOG8CVJQ1	GO:0003677	1/63	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84TRQR	GO:0070613	1/82	regulation of protein processing	biological_process	"Any process that modulates the frequency, rate or extent of protein processing, any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein." [GOC:mah]
EOG84TRQR	GO:0007311	1/82	maternal specification of dorsal/ventral axis, oocyte, germ-line encoded	biological_process	"Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG84TRQR	GO:0009951	1/82	polarity specification of dorsal/ventral axis	biological_process	"Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators]
EOG84TRQR	GO:0050708	1/82	regulation of protein secretion	biological_process	"Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]
EOG84TRQR	GO:0005783	1/82	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8RR8Z9	GO:0016021	18/72	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88974K	GO:0003676	1/30	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8T4G9X	GO:0005737	26/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8T4G9X	GO:0046872	24/89	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8T4G9X	GO:0048103	1/89	somatic stem cell division	biological_process	"The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089]
EOG8T4G9X	GO:0048477	1/89	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8T4G9X	GO:0035162	1/89	embryonic hemopoiesis	biological_process	"The stages of blood cell formation that take place within the embryo." [GOC:bf]
EOG8T4G9X	GO:0005634	1/89	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8T4G9X	GO:0003677	1/89	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8T4G9X	GO:0008283	1/89	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8GQSKS	GO:0008270	24/96	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GQSKS	GO:0004176	19/96	ATP-dependent peptidase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah]
EOG8F4VS5	GO:0046872	24/87	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8F4VS5	GO:0003676	7/87	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8F4VS5	GO:0005634	1/87	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CG2PV	GO:0006355	26/177	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8CG2PV	GO:0044237	19/177	cellular metabolic process	biological_process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
EOG8CG2PV	GO:0003743	5/177	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8CG2PV	GO:0005737	1/177	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CG2PV	GO:0071456	1/177	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG8CG2PV	GO:0005085	1/177	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8CG2PV	GO:0005829	1/177	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8CG2PV	GO:0000398	1/177	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8CG2PV	GO:0071013	1/177	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8CG2PV	GO:0016853	1/177	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8CG2PV	GO:0022008	1/177	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8CG2PV	GO:0006446	1/177	regulation of translational initiation	biological_process	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG8CG2PV	GO:0043087	1/177	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8CG2PV	GO:0005851	1/177	eukaryotic translation initiation factor 2B complex	cellular_component	"A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375]
EOG8CG2PV	GO:0046523	1/177	S-methyl-5-thioribose-1-phosphate isomerase activity	molecular_function	"Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate." [EC:5.3.1.23, RHEA:19992]
EOG8CG2PV	GO:0071011	1/177	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8CG2PV	GO:0006413	1/177	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG8CJXX7	GO:0008270	20/102	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CJXX7	GO:0046872	9/102	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CJXX7	GO:0007476	1/102	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8CJXX7	GO:0008407	1/102	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG8CJXX7	GO:0048749	1/102	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8CJXX7	GO:0005737	1/102	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CJXX7	GO:0002164	1/102	larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088]
EOG8CJXX7	GO:0005515	1/102	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8CJXX7	GO:0003677	1/102	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG82NMFR	GO:0005576	22/76	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG82NMFR	GO:0006953	22/76	acute-phase response	biological_process	"An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals." [ISBN:0198506732]
EOG82NMFM	GO:0005249	2/25	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG82NMFM	GO:0008076	2/25	voltage-gated potassium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
EOG8XKXN8	GO:0030726	1/139	male germline ring canal formation	biological_process	"Formation of the intercellular bridges that connect the germ-line cells of a male cyst." [ISBN:0879694238]
EOG8XKXN8	GO:0007112	1/139	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG8XKXN8	GO:0008017	1/139	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8XKXN8	GO:0007067	1/139	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8XKXN8	GO:0048477	1/139	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8XKXN8	GO:0070938	1/139	contractile ring	cellular_component	"A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles." [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889]
EOG8XKXN8	GO:0031106	1/139	septin ring organization	biological_process	"Control of the formation, spatial distribution, and breakdown of the septin ring." [GOC:mah]
EOG8XKXN8	GO:0008356	1/139	asymmetric cell division	biological_process	"The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
EOG8XKXN8	GO:0007349	1/139	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG8XKXN8	GO:0000281	1/139	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8XKXN8	GO:0005634	1/139	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XKXN8	GO:0003676	1/139	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XKXN8	GO:0005826	1/139	actomyosin contractile ring	cellular_component	"A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, ISBN:0805319409, ISBN:0815316194]
EOG8XKXN8	GO:0017022	1/139	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8XKXN8	GO:0051297	1/139	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8XKXN8	GO:0000915	1/139	actomyosin contractile ring assembly	biological_process	"The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
EOG8XKXN8	GO:0005737	1/139	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XKXN8	GO:0007126	1/139	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8XKXN8	GO:0051533	1/139	positive regulation of NFAT protein import into nucleus	biological_process	"Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai]
EOG8XKXN8	GO:0007279	1/139	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8XKXN8	GO:0000910	1/139	cytokinesis	biological_process	"The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle]
EOG8XKXN8	GO:0043063	1/139	intercellular bridge organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another." [GOC:jid]
EOG8XKXN8	GO:0007009	1/139	plasma membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8XKXN8	GO:0045172	1/139	germline ring canal	cellular_component	"Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801]
EOG8XKXN8	GO:0005515	1/139	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8XKXN8	GO:0035323	1/139	male germline ring canal	cellular_component	"An intercellular bridge that connects the germline cells of a male cyst." [PMID:9635420]
EOG8XKXN8	GO:0045035	1/139	sensory organ precursor cell division	biological_process	"The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597]
EOG8XKXN8	GO:0022008	1/139	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8XKXN8	GO:0046872	1/139	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XKXN8	GO:0032189	1/139	maintenance of actomyosin contractile ring localization	biological_process	"Any process in which an actomyosin contractile ring is maintained in a location and prevented from moving elsewhere." [GOC:mah]
EOG8XKXN8	GO:0008104	1/139	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8XKXN8	GO:0003779	1/139	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8XKXN8	GO:0007423	1/139	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8TXF61	GO:0003676	8/33	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8TXF61	GO:0003964	1/33	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8TXF61	GO:0008270	1/33	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TXF61	GO:0004518	1/33	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8TXF61	GO:0003723	1/33	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8TXF61	GO:0003677	1/33	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG82NMFK	GO:0043565	15/62	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG82NMFK	GO:0005634	15/62	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82NMFD	GO:0048137	1/93	spermatocyte division	biological_process	"The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238]
EOG82NMFD	GO:0007283	1/93	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG82NMFD	GO:0007031	1/93	peroxisome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
EOG82NMFD	GO:0042760	1/93	very long-chain fatty acid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:go_curators]
EOG8F4VSQ	GO:0008413	11/30	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	molecular_function	"Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate = 8-oxo-7,8-dihydroguanosine phosphate + diphosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription." [PMID:15878881]
EOG8F4VSQ	GO:0006281	11/30	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG84QWFB	GO:0016021	15/70	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84QWFB	GO:0022857	13/70	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG84QWFB	GO:0055085	2/70	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG84QWFB	GO:0005215	2/70	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG82NMF1	GO:0006457	36/136	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG82NMF1	GO:0046872	34/136	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82NMF1	GO:0009408	31/136	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG82NMF1	GO:0005524	31/136	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82NMF1	GO:0022008	1/136	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG82NMF0	GO:0046872	1/76	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GJ24T	GO:0006412	24/88	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8GJ24T	GO:0005840	24/88	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8GJ24T	GO:0003735	24/88	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8GJ24T	GO:0004553	1/88	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8GJ24T	GO:0040008	1/88	regulation of growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]
EOG8GJ24T	GO:0005739	1/88	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8GJ24T	GO:0005975	1/88	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8GJ24T	GO:0005763	1/88	mitochondrial small ribosomal subunit	cellular_component	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
EOG8F4VSG	GO:0016491	199/611	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8F4VSG	GO:0047886	2/611	farnesol dehydrogenase activity	molecular_function	"Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH." [EC:1.1.1.216, RHEA:14700]
EOG8F4VSG	GO:0004316	1/611	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
EOG8F4VSG	GO:0016063	1/611	rhodopsin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
EOG8F4VSG	GO:0022008	1/611	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84QWFZ	GO:0003677	36/163	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8R52GT	GO:0005643	27/93	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG8R52GT	GO:0016973	27/93	poly(A)+ mRNA export from nucleus	biological_process	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]
EOG8R52GT	GO:0015031	1/93	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8R52GT	GO:0005739	1/93	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8CJXXM	GO:0006457	5/17	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8CJXXM	GO:0003755	5/17	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8CJXXM	GO:0006412	1/17	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8CJXXM	GO:0005840	1/17	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8CJXXM	GO:0003735	1/17	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8TXF6Z	GO:0006030	11/39	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8TXF6Z	GO:0005576	11/39	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8TXF6Z	GO:0008061	11/39	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8XKXNP	GO:0003676	1/23	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8F20HJ	GO:0005506	142/475	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8F20HJ	GO:0020037	142/475	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8F20HJ	GO:0016705	139/475	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8F20HJ	GO:0004497	138/475	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8F20HJ	GO:0005789	5/475	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8F20HJ	GO:0070330	1/475	aromatase activity	molecular_function	"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
EOG8F20HJ	GO:0033777	1/475	lithocholate 6beta-hydroxylase activity	molecular_function	"Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.13.94, RHEA:18860]
EOG8F20HJ	GO:0050591	1/475	quinine 3-monooxygenase activity	molecular_function	"Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152]
EOG8F20HJ	GO:0033780	1/475	taurochenodeoxycholate 6alpha-hydroxylase activity	molecular_function	"Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O." [EC:1.14.13.97]
EOG8F20HJ	GO:0035220	1/475	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8PK4NQ	GO:0005044	22/94	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8PK4NQ	GO:0004252	21/94	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8PK4NQ	GO:0016020	20/94	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8PK4NQ	GO:0016021	2/94	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PK4NQ	GO:0006508	1/94	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8RR8ZT	GO:0051539	23/91	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8RR8ZT	GO:0016020	23/91	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RR8ZT	GO:0016651	21/91	oxidoreductase activity, acting on NAD(P)H	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8RR8ZT	GO:0003954	2/91	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8RR8ZT	GO:0005739	1/91	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8F20HC	GO:0048749	1/76	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8F20HC	GO:0008134	1/76	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8F20HG	GO:0004367	25/107	glycerol-3-phosphate dehydrogenase [NAD+] activity	molecular_function	"Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+." [EC:1.1.1.8, EC:1.1.1.94]
EOG8F20HG	GO:0009331	25/107	glycerol-3-phosphate dehydrogenase complex	cellular_component	"An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3]
EOG8F20HG	GO:0051287	24/107	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8F20HG	GO:0046168	24/107	glycerol-3-phosphate catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]
EOG8F20HG	GO:0005975	24/107	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8F20HG	GO:0006650	2/107	glycerophospholipid metabolic process	biological_process	"The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]
EOG8F20HG	GO:0005811	1/107	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8F20HG	GO:0006072	1/107	glycerol-3-phosphate metabolic process	biological_process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]
EOG8F20HG	GO:0030018	1/107	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8F20HG	GO:0031430	1/107	M band	cellular_component	"The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194]
EOG8F20HG	GO:0050662	1/107	coenzyme binding	molecular_function	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
EOG8F20HG	GO:0006641	1/107	triglyceride metabolic process	biological_process	"The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732]
EOG8F20HG	GO:0007629	1/107	flight behavior	biological_process	"The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
EOG8PK4NZ	GO:0016746	34/94	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8PK4NZ	GO:0004102	5/94	choline O-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA." [EC:2.3.1.6, RHEA:18824]
EOG8PK4NZ	GO:0004092	2/94	carnitine O-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA." [EC:2.3.1.7, RHEA:21139]
EOG8PK4NZ	GO:0005777	2/94	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8PK4NZ	GO:0006635	1/94	fatty acid beta-oxidation	biological_process	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]
EOG8W6RB6	GO:0046872	28/91	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8W6RB6	GO:0004053	28/91	arginase activity	molecular_function	"Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea." [EC:3.5.3.1]
EOG8W6RB6	GO:0006525	28/91	arginine metabolic process	biological_process	"The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators]
EOG8F20HQ	GO:0008270	9/89	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FN71M	GO:0005694	1/86	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8FN71M	GO:0005813	1/86	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8FN71M	GO:0005739	1/86	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8FN71M	GO:0006979	1/86	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8X6FPQ	GO:0006464	47/145	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG8X6FPQ	GO:0005524	6/145	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X6FPQ	GO:0004835	3/145	tubulin-tyrosine ligase activity	molecular_function	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]
EOG8X6FPQ	GO:0016874	3/145	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8HQH1W	GO:0019428	8/37	allantoin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:go_curators]
EOG8VHNMM	GO:0005886	12/67	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8VHNMM	GO:0005509	12/67	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8VHNMM	GO:0007156	12/67	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8VHNMM	GO:0016021	12/67	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87WR3Z	GO:0004364	77/178	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG87WR3Z	GO:0005737	76/178	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87WR3Z	GO:0016782	4/178	transferase activity, transferring sulfur-containing groups	molecular_function	"Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG87WR3Z	GO:0045174	4/178	glutathione dehydrogenase (ascorbate) activity	molecular_function	"Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [EC:1.8.5.1, RHEA:24427]
EOG87WR3Z	GO:0006749	4/178	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG87WR3Z	GO:0042803	1/178	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG87WR3Z	GO:0055114	1/178	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG87WR3Z	GO:0045454	1/178	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG87WR3Z	GO:0050829	1/178	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG87WR3Z	GO:0009055	1/178	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG87WR3Z	GO:0006726	1/178	eye pigment biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
EOG87WR3Z	GO:0045824	1/178	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG87WR3Z	GO:0004734	1/178	pyrimidodiazepine synthase activity	molecular_function	"Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1]
EOG87WR3Z	GO:0006728	1/178	pteridine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732]
EOG8KD91D	GO:0016020	8/65	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8KD91D	GO:0005524	8/65	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KD91D	GO:0016887	8/65	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8Q87B6	GO:0003676	81/261	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q87B6	GO:0046872	68/261	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Q87B6	GO:0008270	14/261	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q87B6	GO:0005634	5/261	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Q87B6	GO:0005198	1/261	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8Q87B6	GO:0019953	1/261	sexual reproduction	biological_process	"A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny." [GOC:jl, http://en.wikipedia.org/wiki/Sexual_reproduction, ISBN:0387520546]
EOG8Q87B6	GO:0030141	1/261	secretory granule	cellular_component	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732]
EOG8Q87B6	GO:0005576	1/261	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG87WR3R	GO:0006275	38/107	regulation of DNA replication	biological_process	"Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]
EOG87WR3R	GO:0003677	38/107	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG87WR3R	GO:0030337	38/107	DNA polymerase processivity factor activity	molecular_function	"An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it." [GOC:mah, PMID:7903401, PMID:8087839]
EOG87WR3R	GO:0043626	38/107	PCNA complex	cellular_component	"A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation." [GOC:jl, PMID:12829735]
EOG87WR3R	GO:0005634	38/107	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87WR3R	GO:0006260	37/107	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG87WR3R	GO:0006298	2/107	mismatch repair	biological_process	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
EOG87WR3R	GO:0005875	1/107	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG87WR3R	GO:0006272	1/107	leading strand elongation	biological_process	"The synthesis of DNA from a template strand in the 5' to 3' direction; leading strand elongation is continuous as it proceeds in the same direction as the replication fork." [ISBN:071673706X, ISBN:0815316194]
EOG87WR3R	GO:0007052	1/107	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG87WR3R	GO:0006289	1/107	nucleotide-excision repair	biological_process	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]
EOG87WR3R	GO:0022008	1/107	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG87WR3R	GO:0007307	1/107	eggshell chorion gene amplification	biological_process	"Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771]
EOG87WR3R	GO:0006261	1/107	DNA-dependent DNA replication	biological_process	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]
EOG87WR3R	GO:0019730	1/107	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG8KD91J	GO:0000166	25/87	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8KD91J	GO:0003676	24/87	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KD91J	GO:0003729	1/87	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8KD91J	GO:0022008	1/87	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG87WR3G	GO:0044262	26/110	cellular carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
EOG87WR3G	GO:0004459	25/110	L-lactate dehydrogenase activity	molecular_function	"Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27, RHEA:23447]
EOG87WR3G	GO:0006096	24/110	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG87WR3G	GO:0005737	23/110	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87WR3G	GO:0006810	1/110	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG87WR3G	GO:0016021	1/110	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87WR3G	GO:0016616	1/110	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG87WR3F	GO:0016021	23/84	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87WR3F	GO:0004659	23/84	prenyltransferase activity	molecular_function	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]
EOG87WR3F	GO:0009234	17/84	menaquinone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
EOG87WR3F	GO:0016020	1/84	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG87WR3F	GO:0031966	1/84	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG87WR3F	GO:0005739	1/84	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG825886	GO:0046331	1/87	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG825885	GO:0005634	1/317	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG825885	GO:0005576	1/317	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG825885	GO:0003743	1/317	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG825885	GO:0050830	1/317	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG825885	GO:0032504	1/317	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG825885	GO:0002759	1/317	regulation of antimicrobial humoral response	biological_process	"Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]
EOG825885	GO:0050829	1/317	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG825885	GO:0005615	1/317	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8642VD	GO:0006334	10/35	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8642VD	GO:0003677	10/35	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8642VD	GO:0000786	10/35	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8642VD	GO:0005634	10/35	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG825881	GO:0003964	2/105	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG825881	GO:0003723	2/105	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG81VNGP	GO:0007165	36/216	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG81VNGP	GO:0004623	3/216	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG81VNGP	GO:0016651	1/216	oxidoreductase activity, acting on NAD(P)H	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG81VNGP	GO:0005886	1/216	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG81VNGP	GO:0007016	1/216	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG81VNGP	GO:0045169	1/216	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG81VNGP	GO:0045170	1/216	spectrosome	cellular_component	"A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf]
EOG81VNGP	GO:0008092	1/216	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG81VNGP	GO:0022900	1/216	electron transport chain	biological_process	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport]
EOG87WR37	GO:0009058	25/89	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG87WR37	GO:0016779	22/89	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG87WR37	GO:0004475	3/89	mannose-1-phosphate guanylyltransferase activity	molecular_function	"Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose." [EC:2.7.7.13, RHEA:15232]
EOG81VNGW	GO:0003824	17/89	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG81VNGW	GO:0016705	1/89	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG81VNGW	GO:0020037	1/89	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG81VNGW	GO:0005506	1/89	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG81VNGW	GO:0004619	1/89	phosphoglycerate mutase activity	molecular_function	"Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1]
EOG81VNGW	GO:0003677	1/89	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GMXD2	GO:0000398	25/86	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8GMXD2	GO:0005681	24/86	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8GMXD2	GO:0007052	1/86	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8GMXD2	GO:0071013	1/86	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8GMXD2	GO:0005634	1/86	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GMXD2	GO:0003723	1/86	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8GMXD2	GO:0071011	1/86	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8KD916	GO:0019028	6/25	viral capsid	cellular_component	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
EOG8KD916	GO:0005198	6/25	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8KD916	GO:0005524	1/25	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KD916	GO:0006298	1/25	mismatch repair	biological_process	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
EOG8KD916	GO:0030983	1/25	mismatched DNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]
EOG8Z91DD	GO:0030176	10/31	integral component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
EOG8Z91DD	GO:0009059	10/31	macromolecule biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah]
EOG8Q87BK	GO:0005524	58/185	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8Q87BK	GO:0003677	33/185	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Q87BK	GO:0004386	33/185	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8Q87BK	GO:0003676	6/185	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q87BK	GO:0017111	3/185	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8Q87BK	GO:0005634	2/185	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Q87BK	GO:0016740	2/185	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8Q87BK	GO:0034454	1/185	microtubule anchoring at centrosome	biological_process	"Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah]
EOG8Q87BK	GO:0006355	1/185	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Q87BK	GO:0007143	1/185	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8Q87BK	GO:0005509	1/185	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8Q87BK	GO:0006353	1/185	DNA-templated transcription, termination	biological_process	"The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161]
EOG8Q87BK	GO:0016021	1/185	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Q87BK	GO:0008094	1/185	DNA-dependent ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl]
EOG8Q87BK	GO:0000381	1/185	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8Q87BK	GO:0007156	1/185	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8Q87BK	GO:0007283	1/185	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8Q87BK	GO:0005737	1/185	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Q87BK	GO:0006200	1/185	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8ZW7V4	GO:0016772	2/9	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8MD0DV	GO:0004222	27/147	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8MD0DV	GO:0008270	19/147	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MD0DV	GO:0004190	1/147	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8WSZR4	GO:0003676	24/91	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WSZR4	GO:0004523	22/91	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8WSZR4	GO:0005524	1/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WSZR4	GO:0003723	1/91	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8WSZR4	GO:0003964	1/91	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8WSZR4	GO:0004386	1/91	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG89CSPN	GO:0005524	25/92	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG89CSPN	GO:0004674	22/92	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG89CSPN	GO:0007165	20/92	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG89CSPN	GO:0004672	3/92	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG89CSPN	GO:0019732	1/92	antifungal humoral response	biological_process	"An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG89CSPN	GO:0008063	1/92	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG89CSPN	GO:0048262	1/92	determination of dorsal/ventral asymmetry	biological_process	"Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis." [GOC:jid]
EOG89CSPN	GO:0035172	1/92	hemocyte proliferation	biological_process	"The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG89CSPN	GO:0019904	1/92	protein domain specific binding	molecular_function	"Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators]
EOG89CSPN	GO:0009620	1/92	response to fungus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
EOG89CSPN	GO:0007352	1/92	zygotic specification of dorsal/ventral axis	biological_process	"The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf]
EOG89CSPN	GO:0005737	1/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG89CSPN	GO:0030162	1/92	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG89CSPN	GO:0045087	1/92	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG89CSPN	GO:0030097	1/92	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG89CSPN	GO:0006952	1/92	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG89CSPN	GO:0005886	1/92	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG89CSPN	GO:0009950	1/92	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG89CSPN	GO:0004709	1/92	MAP kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
EOG89CSPN	GO:0006915	1/92	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG89CSPN	GO:0046777	1/92	protein autophosphorylation	biological_process	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
EOG89CSPN	GO:0006468	1/92	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG89CSPN	GO:0005515	1/92	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG89CSPQ	GO:0003676	21/102	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K6JKF	GO:0016757	24/90	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8K6JKF	GO:0004581	2/90	dolichyl-phosphate beta-glucosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate." [EC:2.4.1.117]
EOG8K6JKF	GO:0010004	1/90	gastrulation involving germ band extension	biological_process	"A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8K6JKF	GO:0007029	1/90	endoplasmic reticulum organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
EOG8K6JKF	GO:0006487	1/90	protein N-linked glycosylation	biological_process	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]
EOG8K6JKF	GO:0009953	1/90	dorsal/ventral pattern formation	biological_process	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8K6JKF	GO:0040003	1/90	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8K6JKF	GO:0000124	1/90	SAGA complex	cellular_component	"A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012]
EOG8K6JKF	GO:0005789	1/90	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8K6JKF	GO:0007379	1/90	segment specification	biological_process	"The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8K6JKF	GO:0019991	1/90	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG8K6JKF	GO:0007509	1/90	mesoderm migration involved in gastrulation	biological_process	"The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism." [GOC:isa_complete, GOC:sat]
EOG8K6JKF	GO:0007009	1/90	plasma membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8K6JKF	GO:0005783	1/90	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8K6JKF	GO:0007030	1/90	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8K6JKF	GO:0016021	1/90	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8K6JKF	GO:0006493	1/90	protein O-linked glycosylation	biological_process	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]
EOG8K6JKF	GO:0003712	1/90	transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8K6JKF	GO:0009880	1/90	embryonic pattern specification	biological_process	"The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
EOG8FN711	GO:0008270	47/130	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FN711	GO:0004126	46/130	cytidine deaminase activity	molecular_function	"Catalysis of the reaction: cytidine + H2O = uridine + NH3." [EC:3.5.4.5]
EOG8FN711	GO:0016787	1/130	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8FN6Z7	GO:0003676	19/196	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WWV2P	GO:0006412	29/99	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8WWV2P	GO:0003735	29/99	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8WWV2P	GO:0005840	27/99	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8WWV2P	GO:0022627	2/99	cytosolic small ribosomal subunit	cellular_component	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]
EOG8WWV2P	GO:0006407	2/99	rRNA export from nucleus	biological_process	"The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins." [GOC:ma, GOC:mah]
EOG8WWV2P	GO:0035220	1/99	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8XD65B	GO:0005524	64/182	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8XD65B	GO:0006096	62/182	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8XD65B	GO:0004396	40/182	hexokinase activity	molecular_function	"Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1]
EOG8XD65B	GO:0016773	24/182	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8XD65B	GO:0016301	23/182	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8XD65B	GO:0008865	3/182	fructokinase activity	molecular_function	"Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate." [EC:2.7.1.4]
EOG8XD65B	GO:0051156	3/182	glucose 6-phosphate metabolic process	biological_process	"The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]
EOG8XD65B	GO:0046835	3/182	carbohydrate phosphorylation	biological_process	"The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732]
EOG8XD65B	GO:0001678	3/182	cellular glucose homeostasis	biological_process	"A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8XD65B	GO:0005829	3/182	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8XD65B	GO:0019158	3/182	mannokinase activity	molecular_function	"Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate." [EC:2.7.1.7]
EOG8XD65B	GO:0004340	3/182	glucokinase activity	molecular_function	"Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate." [EC:2.7.1.2]
EOG8XD65B	GO:0005975	3/182	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8XD65B	GO:0019318	1/182	hexose metabolic process	biological_process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
EOG8XD65B	GO:0060361	1/182	flight	biological_process	"Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph]
EOG8XD65B	GO:0046331	1/182	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8SJ7WT	GO:0006509	4/16	membrane protein ectodomain proteolysis	biological_process	"The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/]
EOG8SJ7WT	GO:0007219	4/16	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8SJ7WT	GO:0004222	4/16	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8SJ7WT	GO:0008270	3/16	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SJ7WW	GO:0046580	1/95	negative regulation of Ras protein signal transduction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
EOG8P8HZT	GO:0016844	38/131	strictosidine synthase activity	molecular_function	"Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine." [EC:4.3.3.2, RHEA:15016]
EOG8P8HZT	GO:0009058	37/131	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG8P8HZT	GO:0005811	1/131	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8P8HZT	GO:0009986	1/131	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8P8HZT	GO:0004872	1/131	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG85TG25	GO:0015936	27/102	coenzyme A metabolic process	biological_process	"The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
EOG85TG25	GO:0004420	27/102	hydroxymethylglutaryl-CoA reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH." [EC:1.1.1.34, RHEA:15992]
EOG85TG25	GO:0016021	26/102	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85TG25	GO:0008299	23/102	isoprenoid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
EOG85TG25	GO:0050661	23/102	NADP binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]
EOG85TG25	GO:0005789	19/102	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG85TG25	GO:0050662	4/102	coenzyme binding	molecular_function	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
EOG85TG25	GO:0007280	1/102	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG85TG25	GO:0035050	1/102	embryonic heart tube development	biological_process	"The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
EOG85TG25	GO:0008354	1/102	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG85TG25	GO:0007626	1/102	locomotory behavior	biological_process	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
EOG85TG25	GO:0005622	1/102	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG85TG25	GO:0018990	1/102	ecdysis, chitin-based cuticle	biological_process	"The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG85TG25	GO:0008406	1/102	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG85TG25	GO:0035232	1/102	germ cell attraction	biological_process	"The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target." [PMID:12885551]
EOG8J13P1	GO:0008021	22/123	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8J13P1	GO:0005215	22/123	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8J13P1	GO:0016020	22/123	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8J13P1	GO:0006886	8/123	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8J13P1	GO:0046872	1/123	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8J13P1	GO:0035005	1/123	1-phosphatidylinositol-4-phosphate 3-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.154, RHEA:18376]
EOG8P8HZN	GO:0004594	27/128	pantothenate kinase activity	molecular_function	"Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33]
EOG8P8HZN	GO:0005524	27/128	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8P8HZN	GO:0015937	27/128	coenzyme A biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
EOG8P8HZN	GO:0048870	6/128	cell motility	biological_process	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]
EOG8P8HZN	GO:0031514	6/128	motile cilium	cellular_component	"A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998]
EOG8P8HZN	GO:0070328	1/128	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG8P8HZN	GO:0007059	1/128	chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
EOG8P8HZN	GO:0045475	1/128	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8P8HZN	GO:0006979	1/128	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8P8HZN	GO:0005886	1/128	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8P8HZN	GO:0048477	1/128	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8P8HZN	GO:0071480	1/128	cellular response to gamma radiation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah]
EOG8P8HZN	GO:0040011	1/128	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG8P8HZN	GO:0005819	1/128	spindle	cellular_component	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
EOG8P8HZN	GO:0016310	1/128	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG8P8HZN	GO:0007067	1/128	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8P8HZN	GO:0007126	1/128	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8P8HZN	GO:0007283	1/128	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8P8HZN	GO:0005737	1/128	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8P8HZN	GO:0061024	1/128	membrane organization	biological_process	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]
EOG8P8HZN	GO:0007476	1/128	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8SJ7WB	GO:0007264	24/87	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8SJ7WB	GO:0005525	24/87	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8SJ7WB	GO:0005622	23/87	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8SJ7WB	GO:0007030	1/87	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8SJ7WB	GO:0060628	1/87	regulation of ER to Golgi vesicle-mediated transport	biological_process	"Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:dph, GOC:tb]
EOG8SJ7WB	GO:0005515	1/87	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8SJ7WB	GO:0016197	1/87	endosomal transport	biological_process	"The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]
EOG8SJ7WB	GO:0000042	1/87	protein targeting to Golgi	biological_process	"The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah]
EOG8SJ7WB	GO:0048488	1/87	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8SJ7WB	GO:0033227	1/87	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8SJ7WB	GO:0005794	1/87	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8SJ7WB	GO:0019904	1/87	protein domain specific binding	molecular_function	"Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators]
EOG8SJ7WB	GO:0090158	1/87	endoplasmic reticulum membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8SJ7WB	GO:0005802	1/87	trans-Golgi network	cellular_component	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]
EOG8SJ7WB	GO:0070861	1/87	regulation of protein exit from endoplasmic reticulum	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah]
EOG8SJ7WB	GO:0030334	1/87	regulation of cell migration	biological_process	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]
EOG8SJ7WB	GO:0007269	1/87	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG870X14	GO:0016705	4/17	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG870X14	GO:0020037	4/17	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG870X14	GO:0005506	4/17	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG876NGV	GO:0016021	1/25	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8P8HZ6	GO:0008270	17/83	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8P8HZ6	GO:0003676	16/83	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8P8HZ6	GO:0000389	1/83	mRNA 3'-splice site recognition	biological_process	"Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome." [GOC:krc, ISBN:0879695897]
EOG8P8HZ6	GO:0005681	1/83	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8P8HZ6	GO:0000398	1/83	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8P8HZ6	GO:0007052	1/83	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8P8HZ6	GO:0030628	1/83	pre-mRNA 3'-splice site binding	molecular_function	"Interacting selectively and non-covalently with the pre-mRNA 3' splice site sequence." [GOC:jl]
EOG8P8HZ6	GO:0016607	1/83	nuclear speck	cellular_component	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]
EOG8P8HZ3	GO:0046355	41/115	mannan catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732]
EOG8P8HZ3	GO:0004567	41/115	beta-mannosidase activity	molecular_function	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides." [EC:3.2.1.25]
EOG8P8HZ3	GO:0004553	1/115	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8P8HZ3	GO:0005975	1/115	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG85TG2B	GO:0003676	3/25	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85TG2B	GO:0046872	2/25	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85TG2B	GO:0005634	1/25	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85TG2B	GO:0008270	1/25	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8J13PZ	GO:0016021	4/33	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FN6ZR	GO:0005634	26/114	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FN6ZR	GO:0003700	26/114	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8FN6ZR	GO:0000976	20/114	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8FN6ZR	GO:0043565	5/114	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8FN6ZR	GO:0002807	1/114	positive regulation of antimicrobial peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
EOG8FN6ZR	GO:0007487	1/114	analia development	biological_process	"The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu]
EOG8FN6ZR	GO:0007442	1/114	hindgut morphogenesis	biological_process	"The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
EOG8FN6ZR	GO:0007350	1/114	blastoderm segmentation	biological_process	"The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8FN6ZR	GO:0007379	1/114	segment specification	biological_process	"The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8FN6ZR	GO:0004000	1/114	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8FN6ZR	GO:0007377	1/114	germ-band extension	biological_process	"Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:08795694238]
EOG8FN6ZR	GO:0010004	1/114	gastrulation involving germ band extension	biological_process	"A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8FN6ZR	GO:0000977	1/114	RNA polymerase II regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
EOG8FN6ZR	GO:0045893	1/114	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8FN6ZR	GO:0006351	1/114	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8FN6ZR	GO:0005737	1/114	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8FN6ZR	GO:0035215	1/114	genital disc development	biological_process	"Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318]
EOG8FN6ZR	GO:0035224	1/114	genital disc anterior/posterior pattern formation	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318]
EOG8FN6ZR	GO:0007443	1/114	Malpighian tubule morphogenesis	biological_process	"The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089]
EOG8FN6ZR	GO:0009948	1/114	anterior/posterior axis specification	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8FN6ZR	GO:0045944	1/114	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8FN6ZR	GO:0008284	1/114	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG80CM0M	GO:0005634	24/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80CM0M	GO:0006396	24/88	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG80CM0M	GO:0030529	4/88	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG80CM0M	GO:0019013	4/88	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG80CM0M	GO:0030532	1/88	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG80CM0M	GO:0000398	1/88	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG80CM0M	GO:0071013	1/88	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG80CM0M	GO:0007052	1/88	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG80CM0M	GO:0071011	1/88	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG80CM0M	GO:0003723	1/88	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG80CM0M	GO:0005681	1/88	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8BS031	GO:0007018	1/42	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8BS031	GO:0003777	1/42	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG86T5JQ	GO:0004803	2/6	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG86T5JQ	GO:0006313	2/6	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG86T5JQ	GO:0015074	2/6	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG86T5JQ	GO:0003677	2/6	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80CM0B	GO:0006351	21/84	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG80CM0B	GO:0003899	20/84	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG80CM0B	GO:0003677	20/84	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80CM0B	GO:0006383	1/84	transcription from RNA polymerase III promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH]
EOG80CM0B	GO:0005736	1/84	DNA-directed RNA polymerase I complex	cellular_component	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG80CM0B	GO:0005666	1/84	DNA-directed RNA polymerase III complex	cellular_component	"RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG80CM0B	GO:0005875	1/84	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG80CM0B	GO:0006360	1/84	transcription from RNA polymerase I promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
EOG8WWV27	GO:0006811	2/34	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8WWV27	GO:0016021	2/34	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FN6ZB	GO:0008270	33/186	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FN6ZB	GO:0003700	32/186	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8FN6ZB	GO:0005634	32/186	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FN6ZB	GO:0043565	31/186	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8FN6ZB	GO:0016740	2/186	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8FN6ZB	GO:0003677	2/186	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FN6ZB	GO:0000977	1/186	RNA polymerase II regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
EOG8FN6ZB	GO:0035218	1/186	leg disc development	biological_process	"Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
EOG8FN6ZB	GO:0007517	1/186	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8FN6ZB	GO:0007450	1/186	dorsal/ventral pattern formation, imaginal disc	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238]
EOG8FN6ZB	GO:0007399	1/186	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8FN6ZB	GO:0045165	1/186	cell fate commitment	biological_process	"The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
EOG8FN6ZB	GO:0007526	1/186	larval somatic muscle development	biological_process	"The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG8FN6ZB	GO:0007559	1/186	histolysis	biological_process	"The breakdown of tissues; usually, if not always, accompanied by cell death, followed by the complete dissolution of dead tissue." [GOC:dph, GOC:ma]
EOG8FN6ZB	GO:0045944	1/186	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8FN6ZB	GO:0007476	1/186	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8FN6ZB	GO:0007479	1/186	leg disc proximal/distal pattern formation	biological_process	"The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf]
EOG8FN6ZB	GO:0048190	1/186	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8FN6ZB	GO:0006351	1/186	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8FN6ZB	GO:0007411	1/186	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8FN6ZB	GO:0036011	1/186	imaginal disc-derived leg segmentation	biological_process	"Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf]
EOG8FN6ZB	GO:0007451	1/186	dorsal/ventral lineage restriction, imaginal disc	biological_process	"Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402]
EOG8J3ZZK	GO:0005737	28/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8J3ZZK	GO:0006695	28/90	cholesterol biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai]
EOG8J3ZZK	GO:0004631	28/90	phosphomevalonate kinase activity	molecular_function	"Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+)." [EC:2.7.4.2, RHEA:16344]
EOG8J3ZZK	GO:0008299	1/90	isoprenoid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
EOG8J3ZZK	GO:0005524	1/90	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8J3ZZK	GO:0019287	1/90	isopentenyl diphosphate biosynthetic process, mevalonate pathway	biological_process	"The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922]
EOG89PDCN	GO:0004970	1/37	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG89PDCN	GO:0005234	1/37	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG89PDCN	GO:0016020	1/37	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8FBM7S	GO:0016021	21/80	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QRKK3	GO:0005643	26/94	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG8QRKK3	GO:0006606	1/94	protein import into nucleus	biological_process	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]
EOG8QRKK3	GO:0006605	1/94	protein targeting	biological_process	"The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]
EOG8QRKK3	GO:0005487	1/94	nucleocytoplasmic transporter activity	molecular_function	"Enables the directed movement of substances between the nucleus and the cytoplasm of a cell." [GOC:ai]
EOG8QRKK3	GO:0006607	1/94	NLS-bearing protein import into nucleus	biological_process	"The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai]
EOG8QRKK3	GO:0051028	1/94	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8QRKK3	GO:0006913	1/94	nucleocytoplasmic transport	biological_process	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]
EOG85MQK4	GO:0008270	25/108	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG85MQK4	GO:0030163	25/108	protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]
EOG85MQK4	GO:0004842	22/108	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG85MQK4	GO:0016874	2/108	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG834ZP5	GO:0008270	17/81	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG834ZP5	GO:0003676	17/81	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG834ZP5	GO:0005634	17/81	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG834ZP5	GO:0071011	1/81	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG834ZP5	GO:0030532	1/81	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG834ZP5	GO:0005686	1/81	U2 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U2." [GOC:krc, GOC:mah]
EOG834ZP5	GO:0000398	1/81	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG85HVDH	GO:0016021	20/101	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85HVDH	GO:0005267	20/101	potassium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG85HVDH	GO:0046331	1/101	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG84F8QP	GO:0004771	1/89	sterol esterase activity	molecular_function	"Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13]
EOG84F8QP	GO:0031117	1/89	positive regulation of microtubule depolymerization	biological_process	"Any process that activates or increases the frequency, rate or extent of microtubule depolymerization." [GOC:mah]
EOG84F8QP	GO:0007291	1/89	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG84F8QP	GO:0007286	1/89	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG84F8QP	GO:0005930	1/89	axoneme	cellular_component	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]
EOG84F8QP	GO:0004806	1/89	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG84F8QW	GO:0000228	25/90	nuclear chromosome	cellular_component	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
EOG84F8QW	GO:0006338	24/90	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG84F8QW	GO:0007474	1/90	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG84F8QW	GO:0007517	1/90	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG84F8QW	GO:0008587	1/90	imaginal disc-derived wing margin morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG84F8QW	GO:0006357	1/90	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG84F8QW	GO:0044772	1/90	mitotic cell cycle phase transition	biological_process	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]
EOG84F8QW	GO:0048813	1/90	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG84F8QW	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG84F8QW	GO:0005634	1/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84F8QW	GO:0008544	1/90	epidermis development	biological_process	"The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]
EOG84F8QW	GO:0043044	1/90	ATP-dependent chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors." [GOC:jl, PMID:12042764]
EOG84F8QW	GO:0008285	1/90	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG84F8QW	GO:0006337	1/90	nucleosome disassembly	biological_process	"The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG84F8QW	GO:0070983	1/90	dendrite guidance	biological_process	"The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
EOG84F8QW	GO:0070984	1/90	SET domain binding	molecular_function	"Interacting selectively and non-covalently with a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation." [GOC:sart, Pfam:PF00856, PMID:12575990]
EOG84F8QW	GO:0035060	1/90	brahma complex	cellular_component	"A SWI/SNF-type complex that contains the ATPase product of the Drosophila brahma gene, or an ortholog thereof." [GOC:bf, PMID:10809665, PMID:12482982]
EOG84F8QW	GO:0008586	1/90	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG84F8QW	GO:0045893	1/90	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG84F8QW	GO:0006281	1/90	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG84TRPH	GO:0005975	41/141	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG84TRPH	GO:0016757	39/141	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG84TRPH	GO:0008344	1/141	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG84TRPH	GO:0033842	1/141	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244]
EOG84TRPH	GO:0005794	1/141	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG84TRPH	GO:0007528	1/141	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG84TRPH	GO:0009247	1/141	glycolipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators]
EOG84TRPH	GO:0003945	1/141	N-acetyllactosamine synthase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90]
EOG84TRPH	GO:0008376	1/141	acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]
EOG84TRPH	GO:0006044	1/141	N-acetylglucosamine metabolic process	biological_process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
EOG8B2WBZ	GO:0006487	24/82	protein N-linked glycosylation	biological_process	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]
EOG8B2WBZ	GO:0016020	24/82	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8B2WBZ	GO:0003830	24/82	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144]
EOG8B2WBV	GO:0003824	5/146	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8B2WBV	GO:0016787	2/146	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8B2WBV	GO:0005789	1/146	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8B2WBV	GO:0030433	1/146	ER-associated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]
EOG8B2WBV	GO:0006950	1/146	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8B2WBV	GO:0033961	1/146	cis-stilbene-oxide hydrolase activity	molecular_function	"Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9]
EOG8B2WBV	GO:0008233	1/146	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8B2WBV	GO:0016021	1/146	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8B2WBV	GO:0006515	1/146	misfolded or incompletely synthesized protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]
EOG84F8QM	GO:0005975	94/390	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG84F8QM	GO:0004553	93/390	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG84F8QM	GO:0008422	1/390	beta-glucosidase activity	molecular_function	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21]
EOG84F8QM	GO:0008970	1/390	phosphatidylcholine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32]
EOG84F8QM	GO:0052740	1/390	1-acyl-2-lysophosphatidylserine acylhydrolase activity	molecular_function	"Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32]
EOG84F8QM	GO:0052739	1/390	phosphatidylserine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG:R04034]
EOG85HVDV	GO:0006355	7/46	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85HVDV	GO:0050909	1/46	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG85HVDV	GO:0005886	1/46	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG85HVDV	GO:0016021	1/46	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG834ZN4	GO:0005615	3/311	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG834ZN9	GO:0005737	25/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG834ZN9	GO:0003743	25/86	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG834ZN9	GO:0000340	1/86	RNA 7-methylguanosine cap binding	molecular_function	"Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc]
EOG834ZN9	GO:0007476	1/86	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG834ZN9	GO:0022008	1/86	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG834ZN9	GO:0017148	1/86	negative regulation of translation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG834ZN9	GO:0002121	1/86	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG834ZN9	GO:0005515	1/86	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG834ZN9	GO:0030371	1/86	translation repressor activity	molecular_function	"Antagonizes ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai, GOC:clt]
EOG834ZN8	GO:0004298	29/92	threonine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG834ZN8	GO:0019773	28/92	proteasome core complex, alpha-subunit complex	cellular_component	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]
EOG834ZN8	GO:0005634	28/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG834ZN8	GO:0006511	27/92	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG834ZN8	GO:0005737	27/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG834ZN8	GO:0005839	2/92	proteasome core complex	cellular_component	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]
EOG834ZN8	GO:0001673	1/92	male germ cell nucleus	cellular_component	"The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu]
EOG834ZN8	GO:0051603	1/92	proteolysis involved in cellular protein catabolic process	biological_process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]
EOG834ZN8	GO:0043161	1/92	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG834ZN8	GO:0007052	1/92	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG834ZN8	GO:0008283	1/92	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG834ZN8	GO:0005875	1/92	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG834ZN8	GO:0016021	1/92	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG834ZN8	GO:0005515	1/92	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG834ZN8	GO:0000022	1/92	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8JMB3S	GO:0003987	25/104	acetate-CoA ligase activity	molecular_function	"Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [EC:6.2.1.1]
EOG8JMB3S	GO:0016208	23/104	AMP binding	molecular_function	"Interacting selectively and non-covalently with AMP, adenosine monophosphate." [GOC:go_curators]
EOG8JMB3S	GO:0019427	23/104	acetyl-CoA biosynthetic process from acetate	biological_process	"The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate." [MetaCyc:ACETATEUTIL-PWY]
EOG8JMB3S	GO:0003824	3/104	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8JMB3S	GO:0005737	1/104	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8JMB3S	GO:0005524	1/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8JMB3S	GO:0048149	1/104	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG83R62C	GO:0003677	25/78	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG83R62C	GO:0003682	24/78	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG83R62C	GO:0005634	23/78	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83R62C	GO:0008270	21/78	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83R62C	GO:0006338	1/78	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG83R62C	GO:0006355	1/78	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG83R62C	GO:0000124	1/78	SAGA complex	cellular_component	"A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012]
EOG83R62C	GO:0035066	1/78	positive regulation of histone acetylation	biological_process	"Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]
EOG83R62C	GO:0005700	1/78	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG83R62C	GO:0043966	1/78	histone H3 acetylation	biological_process	"The modification of histone H3 by the addition of an acetyl group." [GOC:jl]
EOG83R62C	GO:0006351	1/78	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG83R62C	GO:0005515	1/78	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG83R62C	GO:0035222	1/78	wing disc pattern formation	biological_process	"The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf]
EOG83R62C	GO:0007412	1/78	axon target recognition	biological_process	"The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437]
EOG8JMB3N	GO:0003682	24/95	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8JMB3N	GO:0003677	3/95	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8JMB3N	GO:0018024	2/95	histone-lysine N-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]
EOG8JMB3N	GO:0016571	1/95	histone methylation	biological_process	"The modification of histones by addition of methyl groups." [GOC:ai]
EOG8JMB3N	GO:0000790	1/95	nuclear chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130]
EOG8JMB3N	GO:0051567	1/95	histone H3-K9 methylation	biological_process	"The modification of histone H3 by addition of a methyl group to lysine at position 9 of the histone." [GOC:ai]
EOG8JMB3N	GO:0035097	1/95	histone methyltransferase complex	cellular_component	"A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf]
EOG8JMB3N	GO:0022008	1/95	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8JMB3N	GO:0046976	1/95	histone methyltransferase activity (H3-K27 specific)	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group onto lysine at position 27 of the histone H3 protein." [GOC:ai]
EOG8JMB3N	GO:0006351	1/95	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8JMB3N	GO:0007411	1/95	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8JMB3N	GO:0042054	1/95	histone methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue." [EC:2.1.1.43]
EOG8JMB3N	GO:0016458	1/95	gene silencing	biological_process	"Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb]
EOG8JMB3N	GO:0007517	1/95	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8JMB3N	GO:0035098	1/95	ESC/E(Z) complex	cellular_component	"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]
EOG8JMB3N	GO:0005634	1/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8JMB3N	GO:0046974	1/95	histone methyltransferase activity (H3-K9 specific)	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein." [GOC:ai]
EOG8JMB3N	GO:0045892	1/95	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8JMB3N	GO:0048813	1/95	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8JMB3N	GO:0005515	1/95	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8JMB3N	GO:0035186	1/95	syncytial blastoderm mitotic cell cycle	biological_process	"Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238]
EOG8JMB3N	GO:0006723	1/95	cuticle hydrocarbon biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai]
EOG8JMB3N	GO:0070734	1/95	histone H3-K27 methylation	biological_process	"The modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:mah]
EOG8JMB3N	GO:0003700	1/95	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8B2WB9	GO:0005886	1/136	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8B2WB9	GO:0007411	1/136	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8B2WB9	GO:0007156	1/136	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8B2WB9	GO:0016338	1/136	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	biological_process	"The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb]
EOG8B2WB9	GO:0008038	1/136	neuron recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators]
EOG8B2WB9	GO:0050839	1/136	cell adhesion molecule binding	molecular_function	"Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai]
EOG8B2WB9	GO:0031225	1/136	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG86X1R7	GO:0004518	13/37	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG86X1R7	GO:0003677	13/37	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86X1R7	GO:0008270	7/37	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG86X1R5	GO:0061177	1/88	type Is terminal bouton	cellular_component	"Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons." [GOC:dph, GOC:mc]
EOG86X1R5	GO:0061176	1/88	type Ib terminal bouton	cellular_component	"Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons." [GOC:dph, GOC:mc]
EOG86X1R5	GO:0016191	1/88	synaptic vesicle uncoating	biological_process	"The removal of the protein coat on a synaptic vesicle." [GOC:curators, PMID:10099709]
EOG86X1R5	GO:0016192	1/88	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG86X1R5	GO:0003677	1/88	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86X1R5	GO:0043195	1/88	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG86X1R5	GO:0006457	1/88	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG86X1R5	GO:0016079	1/88	synaptic vesicle exocytosis	biological_process	"Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
EOG86X1R5	GO:0001964	1/88	startle response	biological_process	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
EOG86X1R5	GO:0006887	1/88	exocytosis	biological_process	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
EOG86X1R5	GO:0048854	1/88	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG86X1R5	GO:0031987	1/88	locomotion involved in locomotory behavior	biological_process	"Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
EOG86X1R5	GO:0008021	1/88	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG86X1R5	GO:0005886	1/88	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG86X1R5	GO:0007269	1/88	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG86X1R2	GO:0005840	4/87	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG86X1R2	GO:0003735	1/87	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG86X1R2	GO:0005762	1/87	mitochondrial large ribosomal subunit	cellular_component	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
EOG86X1R2	GO:0006412	1/87	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG83FKBN	GO:0005097	41/106	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG83FKBN	GO:0006451	1/106	translational readthrough	biological_process	"The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:jsg, PMID:11179232]
EOG8QRKKC	GO:0070402	1/7	NADPH binding	molecular_function	"Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
EOG8QRKKC	GO:0009089	1/7	lysine biosynthetic process via diaminopimelate	biological_process	"The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators]
EOG8QRKKC	GO:0008839	1/7	4-hydroxy-tetrahydrodipicolinate reductase	molecular_function	"Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+." [EC:1.17.1.8]
EOG8MKQW2	GO:0003676	3/252	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MKQW2	GO:0000166	3/252	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8MKQW2	GO:0003677	2/252	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8MKQW2	GO:0006360	1/252	transcription from RNA polymerase I promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
EOG8MKQW2	GO:0042302	1/252	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8MKQW2	GO:0005201	1/252	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG8MKQW2	GO:0031012	1/252	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8MKQW2	GO:0000226	1/252	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8MKQW2	GO:0007304	1/252	chorion-containing eggshell formation	biological_process	"The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8MKQW2	GO:0016787	1/252	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8MKQW2	GO:0022008	1/252	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8MKQW2	GO:0005736	1/252	DNA-directed RNA polymerase I complex	cellular_component	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8MKQW2	GO:0042600	1/252	chorion	cellular_component	"A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
EOG8MKQW2	GO:0005874	1/252	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8QRKKZ	GO:0008138	24/91	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG8QRKKZ	GO:0006470	24/91	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG83FKBQ	GO:0051001	1/88	negative regulation of nitric-oxide synthase activity	biological_process	"Any process that stops or reduces the activity of the enzyme nitric-oxide synthase." [GOC:ai]
EOG83FKBQ	GO:0071013	1/88	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG83FKBQ	GO:0005634	1/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83FKBQ	GO:0000398	1/88	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG83FKBQ	GO:0043086	1/88	negative regulation of catalytic activity	biological_process	"Any process that stops or reduces the activity of an enzyme." [GOC:jl, GOC:tb]
EOG83FKBQ	GO:0005737	1/88	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Z38V7	GO:0005874	21/70	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8Z38V7	GO:0000226	21/70	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8Z38V7	GO:0005875	1/70	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8Z38V7	GO:0008017	1/70	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8Z38V7	GO:0007017	1/70	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG84XN0N	GO:0016301	1/87	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG84XMZQ	GO:0005549	69/258	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8NGK1D	GO:0008270	118/444	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NGK1D	GO:0008237	118/444	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8NGK1D	GO:0004177	19/444	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG8NGK1D	GO:0033227	1/444	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8NGK1D	GO:0004463	1/444	leukotriene-A4 hydrolase activity	molecular_function	"Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4)." [EC:3.3.2.6, RHEA:22327]
EOG8NGK1D	GO:0006508	1/444	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8NGK1G	GO:0004725	25/171	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8NGK1G	GO:0050254	2/171	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8NGK1G	GO:0001700	1/171	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8NGK1G	GO:0005001	1/171	transmembrane receptor protein tyrosine phosphatase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8NGK1G	GO:0008201	1/171	heparin binding	molecular_function	"Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]
EOG8NGK1G	GO:0048675	1/171	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG8NGK1G	GO:0005925	1/171	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8NGK1G	GO:0005515	1/171	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8NGK1G	GO:0005875	1/171	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8NGK1G	GO:0016021	1/171	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NGK1G	GO:0007412	1/171	axon target recognition	biological_process	"The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437]
EOG8NGK1G	GO:0048841	1/171	regulation of axon extension involved in axon guidance	biological_process	"Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]
EOG8NGK1G	GO:0007399	1/171	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8NGK1G	GO:0035335	1/171	peptidyl-tyrosine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
EOG8NGK1G	GO:0030424	1/171	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8NGK1G	GO:0032093	1/171	SAM domain binding	molecular_function	"Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230]
EOG8NGK1G	GO:0005886	1/171	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8NGK1G	GO:0048477	1/171	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8NGK1G	GO:0007155	1/171	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8NGK1G	GO:0008045	1/171	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8NGK1G	GO:0045467	1/171	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8NGK1G	GO:0007411	1/171	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8NGK1G	GO:0051124	1/171	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8NGK1G	GO:0008594	1/171	photoreceptor cell morphogenesis	biological_process	"The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
EOG8NGK1G	GO:0008360	1/171	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8NGK1G	GO:0016162	1/171	cellulose 1,4-beta-cellobiosidase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91]
EOG8NGK1G	GO:0031290	1/171	retinal ganglion cell axon guidance	biological_process	"The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs]
EOG8NGK1G	GO:0006470	1/171	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG83N9T4	GO:0016021	3/33	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83N9T4	GO:0005886	3/33	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG83N9T4	GO:0050909	3/33	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8QJV2V	GO:0008146	160/572	sulfotransferase activity	molecular_function	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]
EOG8QJV2V	GO:0004027	62/572	alcohol sulfotransferase activity	molecular_function	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2]
EOG8QJV2V	GO:0004304	10/572	estrone sulfotransferase activity	molecular_function	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4]
EOG8QJV2V	GO:0005829	3/572	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8QJV2V	GO:0051923	3/572	sulfation	biological_process	"The addition of a sulfate group to a molecule." [http://www.onelook.com]
EOG8QJV2V	GO:0006805	2/572	xenobiotic metabolic process	biological_process	"The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2]
EOG8QJV2V	GO:0004062	1/572	aryl sulfotransferase activity	molecular_function	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1]
EOG8QJV2Z	GO:0007606	16/1207	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8QJV2Z	GO:0005515	9/1207	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QJV2Z	GO:0016021	3/1207	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QJV2Z	GO:0008039	1/1207	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8QJV2Z	GO:0050914	1/1207	sensory perception of salty taste	biological_process	"The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8QJV2Z	GO:0002115	1/1207	store-operated calcium entry	biological_process	"A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991]
EOG8QJV2Z	GO:0035199	1/1207	salt aversion	biological_process	"The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf]
EOG8QJV2Z	GO:0048149	1/1207	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8QJV2Z	GO:0005886	1/1207	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8QNQD0	GO:0003677	21/117	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8QNQD0	GO:0003676	2/117	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QNQD0	GO:0003964	1/117	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8QNQD0	GO:0003723	1/117	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8X9B0N	GO:0003676	2/429	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X9B0N	GO:0003899	1/429	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8X9B0N	GO:0003677	1/429	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X9B0N	GO:0006351	1/429	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8X9B0N	GO:0031012	1/429	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8X9B0N	GO:0004222	1/429	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8X9B0N	GO:0008270	1/429	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8F4VRB	GO:0004970	27/163	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8F4VRB	GO:0005234	27/163	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8F4VRB	GO:0016020	20/163	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8F4VRB	GO:0016021	9/163	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F4VRB	GO:0005215	8/163	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8F4VRB	GO:0015276	2/163	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8F4VRB	GO:0036081	2/163	extracellular ammonia-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
EOG8F4VRB	GO:0034220	2/163	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8F4VRB	GO:0009593	2/163	detection of chemical stimulus	biological_process	"The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
EOG8QNQD6	GO:0004190	4/578	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8QNQD6	GO:0003676	3/578	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QNQD6	GO:0003964	1/578	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8QNQD6	GO:0008270	1/578	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8QNQD6	GO:0003723	1/578	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8QNQD6	GO:0015074	1/578	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8KWN70	GO:0042765	12/59	GPI-anchor transamidase complex	cellular_component	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]
EOG8KWN70	GO:0016255	12/59	attachment of GPI anchor to protein	biological_process	"A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595]
EOG8GJ23Z	GO:0006506	64/125	GPI anchor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
EOG8GJ23Z	GO:0005789	64/125	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8GJ23Z	GO:0016740	63/125	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8GJ23Z	GO:0004672	1/125	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8GJ23Z	GO:0005634	1/125	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GJ23Z	GO:0008484	1/125	sulfuric ester hydrolase activity	molecular_function	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]
EOG8GJ23Z	GO:0003746	1/125	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG8GJ23Z	GO:0005524	1/125	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8GJ23Z	GO:0005853	1/125	eukaryotic translation elongation factor 1 complex	cellular_component	"A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950]
EOG8M0HGC	GO:0016021	35/133	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M0HGC	GO:0005000	29/133	vasopressin receptor activity	molecular_function	"Combining with vasopressin to initiate a change in cell activity." [GOC:ai]
EOG8M0HGC	GO:0004930	6/133	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8M0HGC	GO:0018990	1/133	ecdysis, chitin-based cuticle	biological_process	"The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8M0HGC	GO:0007186	1/133	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8M0HGC	GO:0008188	1/133	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8M0HGC	GO:0007218	1/133	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8M0HGC	GO:0005887	1/133	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82FVXZ	GO:0007279	1/76	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG82FVXZ	GO:0016480	1/76	negative regulation of transcription from RNA polymerase III promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter." [GOC:go_curators]
EOG82FVXZ	GO:0005938	1/76	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG82FVXZ	GO:0005643	1/76	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG82FVXZ	GO:0007278	1/76	pole cell fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
EOG82FVXZ	GO:0007315	1/76	pole plasm assembly	biological_process	"Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG82FVXZ	GO:0034399	1/76	nuclear periphery	cellular_component	"The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah]
EOG82FVXZ	GO:0005634	1/76	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82FVXZ	GO:0045892	1/76	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8577P8	GO:0016881	37/106	acid-amino acid ligase activity	molecular_function	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
EOG8577P8	GO:0004842	7/106	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8577P8	GO:0005524	1/106	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8577P8	GO:0005515	1/106	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8577P8	GO:0022008	1/106	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG808QNR	GO:0005856	8/68	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8GJ237	GO:0016021	48/257	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GJ237	GO:0003917	24/257	DNA topoisomerase type I activity	molecular_function	"Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]
EOG8GJ237	GO:0003677	24/257	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GJ237	GO:0006265	24/257	DNA topological change	biological_process	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]
EOG8GJ237	GO:0005694	23/257	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8GJ237	GO:0008270	22/257	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GJ237	GO:0042246	1/257	tissue regeneration	biological_process	"The regrowth of lost or destroyed tissues." [GOC:curators]
EOG8GJ237	GO:0006909	1/257	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8GJ237	GO:0005739	1/257	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8GJ237	GO:0005634	1/257	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GJ237	GO:0003916	1/257	DNA topoisomerase activity	molecular_function	"Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192]
EOG8GJ237	GO:0005524	1/257	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8GJ237	GO:0050829	1/257	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GJ237	GO:0004185	1/257	serine-type carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8GJ237	GO:0000002	1/257	mitochondrial genome maintenance	biological_process	"The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw]
EOG8GJ237	GO:0048589	1/257	developmental growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]
EOG8GJ237	GO:0005215	1/257	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8GJ237	GO:0035010	1/257	encapsulation of foreign target	biological_process	"Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920]
EOG8GJ237	GO:0000724	1/257	double-strand break repair via homologous recombination	biological_process	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]
EOG8F20K1	GO:0051028	1/51	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8F20K1	GO:0005634	1/51	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XWJBR	GO:0005509	25/91	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8XWJBR	GO:0007156	20/91	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8XWJBR	GO:0016021	19/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XWJBR	GO:0005576	1/91	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8XWJBR	GO:0045211	1/91	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8XWJBR	GO:0005887	1/91	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XWJBR	GO:0016339	1/91	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
EOG83N9TJ	GO:0005506	404/1184	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG83N9TJ	GO:0020037	404/1184	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG83N9TJ	GO:0016705	391/1184	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG83N9TJ	GO:0004497	374/1184	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG83N9TJ	GO:0005789	17/1184	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG83N9TJ	GO:0070330	6/1184	aromatase activity	molecular_function	"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
EOG83N9TJ	GO:0052869	6/1184	arachidonic acid omega-hydroxylase activity	molecular_function	"Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid." [KEGG:R07041]
EOG83N9TJ	GO:0018685	6/1184	alkane 1-monooxygenase activity	molecular_function	"Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3]
EOG83N9TJ	GO:0016539	3/1184	intein-mediated protein splicing	biological_process	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]
EOG83N9TJ	GO:0007165	2/1184	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG83N9TJ	GO:0005622	2/1184	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG83N9TJ	GO:0007618	1/1184	mating	biological_process	"The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546]
EOG83N9TJ	GO:0005201	1/1184	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG83N9TJ	GO:0005581	1/1184	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG83N9TJ	GO:0050051	1/1184	leukotriene-B4 20-monooxygenase activity	molecular_function	"Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN]
EOG83N9TJ	GO:0052871	1/1184	alpha-tocopherol omega-hydroxylase activity	molecular_function	"Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003]
EOG83N9TJ	GO:0006629	1/1184	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG83N9TJ	GO:0005737	1/1184	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83N9TJ	GO:0005811	1/1184	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8Z38VB	GO:0016020	41/234	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Z38VB	GO:0008654	41/234	phospholipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8Z38VB	GO:0003841	41/234	1-acylglycerol-3-phosphate O-acyltransferase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51, GOC:ab]
EOG8Z38VB	GO:0016746	6/234	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8Z38VB	GO:0048149	1/234	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8XPSWP	GO:0005634	16/60	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XPSWP	GO:0043565	16/60	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8XPSWP	GO:0003700	16/60	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z38VJ	GO:0005524	42/109	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8Z38VJ	GO:0017111	38/109	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8Z38VJ	GO:0015031	2/109	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8Z38VJ	GO:0005737	2/109	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Z38VJ	GO:0006200	2/109	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8Z38VJ	GO:0007269	2/109	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8Z38VJ	GO:0046872	2/109	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z38VJ	GO:0007274	2/109	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8Z38VJ	GO:0016082	2/109	synaptic vesicle priming	biological_process	"The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342]
EOG8Z38VJ	GO:0016887	2/109	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8Z38VJ	GO:0031629	1/109	synaptic vesicle fusion to presynaptic membrane	biological_process	"Fusion of the membrane of a synaptic vesicle with its target presynaptic membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [ISBN:0071120009]
EOG8Z38VJ	GO:0043195	1/109	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG8Z38VJ	GO:0008233	1/109	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8Z38VJ	GO:0008582	1/109	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8Z38VJ	GO:0016192	1/109	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8Z38VJ	GO:0032403	1/109	protein complex binding	molecular_function	"Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:mah]
EOG8Z38VJ	GO:0035540	1/109	positive regulation of SNARE complex disassembly	biological_process	"Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
EOG8Z38VJ	GO:0051260	1/109	protein homooligomerization	biological_process	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
EOG8Z38VJ	GO:0007430	1/109	terminal branching, open tracheal system	biological_process	"Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG8Z38VJ	GO:0048172	1/109	regulation of short-term neuronal synaptic plasticity	biological_process	"A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290]
EOG8Z38VJ	GO:0007030	1/109	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8Z38VJ	GO:0006909	1/109	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8Z38VJ	GO:0034214	1/109	protein hexamerization	biological_process	"The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits." [GOC:ecd]
EOG8Z38VJ	GO:0060439	1/109	trachea morphogenesis	biological_process	"The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG84XN03	GO:0015016	2/25	[heparan sulfate]-glucosamine N-sulfotransferase activity	molecular_function	"Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine." [EC:2.8.2.8]
EOG84XN03	GO:0016787	2/25	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG82NMG9	GO:0005509	105/381	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG82NMG9	GO:0043565	1/381	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG82NMG9	GO:0032440	1/381	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG82NMG9	GO:0003700	1/381	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z653R	GO:0016192	26/83	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8Z653R	GO:0016020	25/83	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Z653R	GO:0006886	9/83	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8Z653R	GO:0005484	1/83	SNAP receptor activity	molecular_function	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
EOG8Z653R	GO:0035088	1/83	establishment or maintenance of apical/basal cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483]
EOG8Z653R	GO:0007269	1/83	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8Z653R	GO:0005769	1/83	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG8Z653R	GO:0008285	1/83	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8Z653R	GO:0045807	1/83	positive regulation of endocytosis	biological_process	"Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators]
EOG8Z653R	GO:0035073	1/83	pupariation	biological_process	"The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
EOG8Z653R	GO:0005515	1/83	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8Z653R	GO:0035264	1/83	multicellular organism growth	biological_process	"The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb]
EOG8Z653R	GO:0034058	1/83	endosomal vesicle fusion	biological_process	"The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]
EOG8Z653R	GO:0016081	1/83	synaptic vesicle docking	biological_process	"The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342]
EOG8Z653R	GO:0005886	1/83	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8Z653R	GO:0048227	1/83	plasma membrane to endosome transport	biological_process	"Transport of a vesicle from the plasma membrane to the endosome." [GOC:jid]
EOG8QFZTB	GO:0048278	26/92	vesicle docking	biological_process	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]
EOG8QFZTB	GO:0005737	26/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8QFZTB	GO:0006887	26/92	exocytosis	biological_process	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
EOG82JR7S	GO:0032542	28/62	sulfiredoxin activity	molecular_function	"Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R." [EC:1.8.98.2, PMID:16102934]
EOG82JR7S	GO:0005524	26/62	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82VBZ1	GO:0003964	6/161	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG82VBZ1	GO:0003676	6/161	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82VBZ1	GO:0003723	6/161	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG82VBZ1	GO:0008270	4/161	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG82VBZ1	GO:0015074	3/161	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG82VBZ1	GO:0004190	2/161	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8D55FK	GO:0005615	3/466	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8D55FK	GO:0032504	3/466	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8D55FK	GO:0008233	2/466	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8D55FK	GO:0046692	1/466	sperm competition	biological_process	"Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514]
EOG8D55FK	GO:0030414	1/466	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8D55FK	GO:0030162	1/466	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8D55FK	GO:0010951	1/466	negative regulation of endopeptidase activity	biological_process	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG8D55FK	GO:0010466	1/466	negative regulation of peptidase activity	biological_process	"Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG8D55FK	GO:0004867	1/466	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG8D55FK	GO:0007610	1/466	behavior	biological_process	"The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
EOG8D55FK	GO:0045861	1/466	negative regulation of proteolysis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
EOG82VBZ5	GO:0005509	2/118	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG82VBZ5	GO:0005875	1/118	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG82VBZ5	GO:0031532	1/118	actin cytoskeleton reorganization	biological_process	"A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]
EOG82VBZ5	GO:0045179	1/118	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG82VBZ5	GO:0048471	1/118	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG82VBZ5	GO:0007017	1/118	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG82VBZ5	GO:0000915	1/118	actomyosin contractile ring assembly	biological_process	"The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
EOG82VBZ5	GO:0048190	1/118	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG82VBZ5	GO:0007476	1/118	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG82VBZ5	GO:0016360	1/118	sensory organ precursor cell fate determination	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
EOG82VBZ5	GO:0008017	1/118	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG82VBZ5	GO:0005813	1/118	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8QFZTV	GO:0003824	25/119	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8QFZTV	GO:0005509	25/119	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8QFZTV	GO:0008936	3/119	nicotinamidase activity	molecular_function	"Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3." [EC:3.5.1.19]
EOG8QFZTV	GO:0003735	1/119	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8QFZTV	GO:0043524	1/119	negative regulation of neuron apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
EOG8QFZTV	GO:0008340	1/119	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8QFZTV	GO:0005840	1/119	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8QFZTV	GO:0006979	1/119	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8QFZTV	GO:0006412	1/119	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8C8B6H	GO:0005524	25/87	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8C8B6H	GO:0016887	23/87	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8C8B6H	GO:0015439	2/87	heme-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [EC:3.6.3.41]
EOG8C8B6H	GO:0015417	1/87	polyamine-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)." [EC:3.6.3.31]
EOG8H48HH	GO:0009235	4/153	cobalamin metabolic process	biological_process	"The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators]
EOG8H48HH	GO:0005739	4/153	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8H48HH	GO:0048488	1/153	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8H48HH	GO:0030036	1/153	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG89CSQQ	GO:0007155	18/47	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG89CSQQ	GO:0042246	18/47	tissue regeneration	biological_process	"The regrowth of lost or destroyed tissues." [GOC:curators]
EOG89CSQQ	GO:0016021	18/47	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89CSQQ	GO:0016491	1/47	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG89CSQQ	GO:0046331	1/47	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8W6RCD	GO:0031083	1/51	BLOC-1 complex	cellular_component	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]
EOG8W6RCH	GO:0003735	24/77	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8W6RCH	GO:0000166	24/77	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8W6RCH	GO:0006412	24/77	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8W6RCH	GO:0005840	23/77	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8W6RCH	GO:0005739	1/77	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8W6RCH	GO:0005762	1/77	mitochondrial large ribosomal subunit	cellular_component	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
EOG8HX7FQ	GO:0008092	1/100	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8HX7FQ	GO:0001654	1/100	eye development	biological_process	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
EOG8HX7FQ	GO:0042052	1/100	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8HX7FQ	GO:0016013	1/100	syntrophin complex	cellular_component	"A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [http://www.dmd.nl/DGC.html#syn]
EOG8HX7FQ	GO:0008582	1/100	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8W10V5	GO:0043565	31/186	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8W10V5	GO:0003700	31/186	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8W10V5	GO:0005634	31/186	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8W10V5	GO:0003677	7/186	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8W10V5	GO:0045944	1/186	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8W10V5	GO:0007480	1/186	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8W10V5	GO:0007383	1/186	specification of segmental identity, antennal segment	biological_process	"The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
EOG8W10V5	GO:0045664	1/186	regulation of neuron differentiation	biological_process	"Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
EOG8W10V5	GO:0007476	1/186	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8W10V5	GO:0007479	1/186	leg disc proximal/distal pattern formation	biological_process	"The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf]
EOG8W10V5	GO:0001752	1/186	compound eye photoreceptor fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
EOG8W10V5	GO:0001654	1/186	eye development	biological_process	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
EOG8W10V5	GO:0007380	1/186	specification of segmental identity, head	biological_process	"The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
EOG8W10V5	GO:0007525	1/186	somatic muscle development	biological_process	"The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
EOG8W10V5	GO:0034504	1/186	protein localization to nucleus	biological_process	"A process in which a protein is transported to, or maintained in, a location within the nucleus." [GOC:ecd]
EOG8W10V5	GO:0007422	1/186	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8W10V5	GO:0006357	1/186	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8W10V5	GO:0003705	1/186	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG8W10V5	GO:0006366	1/186	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8W10V5	GO:0048749	1/186	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8W10V5	GO:0005515	1/186	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8W10V5	GO:0007432	1/186	salivary gland boundary specification	biological_process	"Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957]
EOG8W10V5	GO:0000060	1/186	protein import into nucleus, translocation	biological_process	"A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope." [GOC:curators, ISBN:0198506732, PMID:14570049, PMID:9126736]
EOG8W10V5	GO:0035282	1/186	segmentation	biological_process	"The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689]
EOG8W10V5	GO:0005737	1/186	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8W10V5	GO:0009954	1/186	proximal/distal pattern formation	biological_process	"The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:isa_complete]
EOG8W10V5	GO:0042659	1/186	regulation of cell fate specification	biological_process	"Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators]
EOG8W10V5	GO:0006355	1/186	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8W10V5	GO:0048735	1/186	haltere morphogenesis	biological_process	"The process in which the anatomical structures of a haltere are generated and organized." [GOC:jid, GOC:rc]
EOG8W10V5	GO:0005667	1/186	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8W10V5	GO:0010092	1/186	specification of organ identity	biological_process	"The regionalization process in which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
EOG8W10V5	GO:0008134	1/186	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8W10V5	GO:0007420	1/186	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG8W10V0	GO:0005975	167/551	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8W10V0	GO:0006032	166/551	chitin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8W10V0	GO:0004568	166/551	chitinase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
EOG8W10V0	GO:0008061	105/551	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8W10V0	GO:0005576	104/551	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8W10V0	GO:0006030	4/551	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8W10V0	GO:0016021	3/551	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W10V0	GO:0004553	3/551	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8W10V0	GO:0005615	2/551	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8W10V0	GO:0000272	2/551	polysaccharide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:go_curators]
EOG82JR79	GO:0003700	24/73	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG82JR79	GO:0043565	24/73	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG82JR79	GO:0005634	22/73	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82JR79	GO:0007275	14/73	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG82JR79	GO:0001748	1/73	optic lobe placode development	biological_process	"The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833]
EOG82JR79	GO:0004000	1/73	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG82NMGR	GO:0005739	21/66	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG82NMGR	GO:0004129	21/66	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8D55F0	GO:0005634	25/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D55F0	GO:0007049	25/88	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG8D55F0	GO:0006281	25/88	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8D55F0	GO:0017111	2/88	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8D55F0	GO:0005524	2/88	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG808QR3	GO:0005874	1/45	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG808QR3	GO:0007021	1/45	tubulin complex assembly	biological_process	"The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah]
EOG82586Z	GO:0005524	24/86	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82586Z	GO:0008026	24/86	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG82586Z	GO:0003676	22/86	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82586Z	GO:0003677	2/86	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG82586Z	GO:0006281	2/86	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG82586Z	GO:0009951	1/86	polarity specification of dorsal/ventral axis	biological_process	"Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators]
EOG82586Z	GO:0030717	1/86	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG82586Z	GO:0007294	1/86	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG82586Z	GO:0009949	1/86	polarity specification of anterior/posterior axis	biological_process	"Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators]
EOG82586Z	GO:0006417	1/86	regulation of translation	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG82586Z	GO:0016321	1/86	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG82586Z	GO:0004386	1/86	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG82586Z	GO:0008152	1/86	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG82586Z	GO:0048477	1/86	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG82586Z	GO:0008298	1/86	intracellular mRNA localization	biological_process	"Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai]
EOG82586Z	GO:0009994	1/86	oocyte differentiation	biological_process	"The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu]
EOG80P6PH	GO:0006897	23/89	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG80P6PH	GO:0016020	22/89	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG80P6PH	GO:0030125	1/89	clathrin vesicle coat	cellular_component	"A clathrin coat found on a vesicle." [GOC:mah]
EOG80P6PH	GO:0005905	1/89	coated pit	cellular_component	"A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]
EOG80P6PH	GO:0015031	1/89	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG89PDCG	GO:0003676	100/519	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89PDCG	GO:0046872	76/519	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89PDCG	GO:0008270	20/519	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG89PDCG	GO:0005634	20/519	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG89PDCG	GO:0015074	4/519	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG89PDCG	GO:0045931	1/519	positive regulation of mitotic cell cycle	biological_process	"Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG89PDCG	GO:0006357	1/519	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG89PDCG	GO:0030178	1/519	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG89PDCG	GO:0007476	1/519	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG89PDCG	GO:0046331	1/519	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG89PDCG	GO:0031935	1/519	regulation of chromatin silencing	biological_process	"Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah]
EOG89PDCG	GO:0007155	1/519	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG89PDCG	GO:0045892	1/519	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG80P6PC	GO:0004030	37/289	aldehyde dehydrogenase [NAD(P)+] activity	molecular_function	"Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5]
EOG80P6PC	GO:0006081	36/289	cellular aldehyde metabolic process	biological_process	"The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732]
EOG80P6PC	GO:0005975	28/289	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG80P6PC	GO:0005840	26/289	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG80P6PC	GO:0006412	26/289	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG80P6PC	GO:0003735	26/289	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG80P6PC	GO:0016773	26/289	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG80P6PC	GO:0016301	22/289	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG80P6PC	GO:0004370	2/289	glycerol kinase activity	molecular_function	"Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21647]
EOG80P6PC	GO:0005811	1/289	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG80P6PC	GO:0000022	1/289	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG80P6PC	GO:0007052	1/289	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG80P6PC	GO:0007264	1/289	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG80P6PC	GO:0016491	1/289	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG80P6PC	GO:0005525	1/289	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG80P6PC	GO:0005622	1/289	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG80P6PC	GO:0016020	1/289	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG80P6PD	GO:0008289	3/54	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG8DNHMJ	GO:0005634	6/24	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8DNHMJ	GO:0043565	6/24	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8DNHMJ	GO:0003700	6/24	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8DNHMJ	GO:0004000	1/24	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG82RGNG	GO:0016746	2/166	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG82RGNG	GO:0050832	1/166	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG82RGNG	GO:0007527	1/166	adult somatic muscle development	biological_process	"The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG82RGNG	GO:0072686	1/166	mitotic spindle	cellular_component	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
EOG8G7FCS	GO:0050909	12/64	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8G7FCS	GO:0005886	12/64	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8G7FCS	GO:0016021	12/64	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G7FCR	GO:0005975	35/112	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8G7FCR	GO:0004553	34/112	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8G7FCR	GO:0032450	1/112	maltose alpha-glucosidase activity	molecular_function	"Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141]
EOG8G7FCF	GO:0003700	24/83	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8G7FCF	GO:0008270	24/83	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8G7FCF	GO:0005634	24/83	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81C99X	GO:0005975	20/89	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG81C99X	GO:0004415	20/89	hyalurononglucosaminidase activity	molecular_function	"Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35]
EOG81C99X	GO:0006952	16/89	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8J9QCX	GO:0005525	26/90	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8J9QCX	GO:0003924	25/90	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8J9QCX	GO:0003746	23/90	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG8J9QCX	GO:0005739	14/90	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8J9QCX	GO:0070125	14/90	mitochondrial translational elongation	biological_process	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah]
EOG8J9QCX	GO:0006184	14/90	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8J9QCX	GO:0005622	9/90	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8J9QCX	GO:0005634	1/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8J9QCX	GO:0004781	1/90	sulfate adenylyltransferase (ATP) activity	molecular_function	"Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4]
EOG8G7FCN	GO:0008430	1/29	selenium binding	molecular_function	"Interacting selectively and non-covalently with selenium (Se)." [GOC:ai]
EOG8J9QCT	GO:0004252	24/91	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8J9QCT	GO:0003824	1/91	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8J9QCT	GO:0006508	1/91	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8NCPVV	GO:0005743	30/183	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8NCPVV	GO:0004129	30/183	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8NCPVV	GO:0016020	5/183	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NCPVV	GO:0016192	4/183	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8NCPVV	GO:0006886	3/183	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8NCPVV	GO:0046872	2/183	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NCPVV	GO:0005938	1/183	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8NCPVV	GO:0031594	1/183	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8NCPVV	GO:0003676	1/183	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NCPVV	GO:0045787	1/183	positive regulation of cell cycle	biological_process	"Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators]
EOG8NCPVV	GO:0007274	1/183	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8NCPVV	GO:0005739	1/183	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8NCPVV	GO:0007528	1/183	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8NCPVV	GO:0005811	1/183	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8NCPVV	GO:0005484	1/183	SNAP receptor activity	molecular_function	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
EOG8MSGF3	GO:0005634	26/91	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8MSGF3	GO:0032786	26/91	positive regulation of DNA-templated transcription, elongation	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]
EOG8MSGF3	GO:0008270	26/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MSGF3	GO:0006351	25/91	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8MSGF3	GO:0003746	4/91	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG8MSGF3	GO:0008023	1/91	transcription elongation factor complex	cellular_component	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]
EOG8MSGF3	GO:0032785	1/91	negative regulation of DNA-templated transcription, elongation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]
EOG8MSGF3	GO:0000122	1/91	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8MSGF3	GO:0006368	1/91	transcription elongation from RNA polymerase II promoter	biological_process	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
EOG8MSGF3	GO:0005703	1/91	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG8MSGF3	GO:0046982	1/91	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8MSGF3	GO:0005705	1/91	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG8MSGF3	GO:0045944	1/91	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG82RGNM	GO:0019781	1/95	NEDD8 activating enzyme activity	molecular_function	"Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade." [PMID:12646924]
EOG82RGNM	GO:0005737	1/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82RGNM	GO:0000338	1/95	protein deneddylation	biological_process	"The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]
EOG82RGNM	GO:0007095	1/95	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG82RGNM	GO:0050821	1/95	protein stabilization	biological_process	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]
EOG82RGNM	GO:0051726	1/95	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG82RGNM	GO:0022008	1/95	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG82RGNM	GO:0008180	1/95	COP9 signalosome	cellular_component	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]
EOG82RGNM	GO:0048477	1/95	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG82RGNM	GO:0046331	1/95	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG82RGNM	GO:0000502	1/95	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG87WR2Z	GO:0008270	24/92	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87WR2Z	GO:0006511	24/92	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG87WR2Z	GO:0004221	3/92	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG87WR2Z	GO:0071011	1/92	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG87WR2Z	GO:0000398	1/92	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG87WR2Z	GO:0008233	1/92	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8DNHM6	GO:0003725	25/130	double-stranded RNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]
EOG8DNHM6	GO:0008270	20/130	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DNHM6	GO:0003899	20/130	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8DNHM6	GO:0006351	20/130	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8DNHM6	GO:0003677	17/130	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DNHM6	GO:0005634	15/130	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8DNHM6	GO:0003676	2/130	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DNHM6	GO:0003700	1/130	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8JQ6DR	GO:0008284	1/84	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG8JQ6DR	GO:0007000	1/84	nucleolus organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah]
EOG8JQ6DR	GO:0005730	1/84	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8JQ6DR	GO:0035214	1/84	eye-antennal disc development	biological_process	"Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8JQ6DR	GO:0045572	1/84	positive regulation of imaginal disc growth	biological_process	"Any process that activates or increases the frequency, rate or extent of imaginal disc growth." [GOC:go_curators]
EOG8JQ6DR	GO:0043066	1/84	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8JQ6DR	GO:0030307	1/84	positive regulation of cell growth	biological_process	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8QZB0S	GO:0016021	30/103	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QZB0S	GO:0035556	30/103	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8QZB0S	GO:0000166	29/103	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8QZB0S	GO:0009190	27/103	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG8QZB0S	GO:0016849	27/103	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG8QZB0S	GO:0004016	3/103	adenylate cyclase activity	molecular_function	"Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]
EOG8QZB0S	GO:0040015	1/103	negative regulation of multicellular organism growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG8QZB0S	GO:0042594	1/103	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8QZB0S	GO:0006171	1/103	cAMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]
EOG8QZB0S	GO:0002165	1/103	instar larval or pupal development	biological_process	"The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
EOG8QZB0S	GO:0046872	1/103	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QZB0S	GO:0005524	1/103	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CZDVT	GO:0005654	25/93	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG8CZDVT	GO:0005730	25/93	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8CZDVT	GO:0043021	23/93	ribonucleoprotein complex binding	molecular_function	"Interacting selectively and non-covalently with any complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]
EOG8CZDVT	GO:0000466	23/93	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	biological_process	"Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
EOG8CZDVT	GO:0000463	23/93	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	biological_process	"Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
EOG8CZDVT	GO:0030687	23/93	preribosome, large subunit precursor	cellular_component	"A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516]
EOG8CZDVT	GO:0006364	2/93	rRNA processing	biological_process	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
EOG8CZDVT	GO:0004402	1/93	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8CZDVT	GO:0022008	1/93	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8CZDVT	GO:0035206	1/93	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8XKXPH	GO:0016020	142/797	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XKXPH	GO:0005515	4/797	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8XKXPH	GO:0015031	1/797	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8XKXPH	GO:0046331	1/797	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8XKXPH	GO:0005789	1/797	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8XKXPH	GO:0016021	1/797	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88KTR1	GO:0005524	23/92	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88KTR1	GO:0004674	23/92	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG88KTR1	GO:0001745	1/92	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG88KTR1	GO:0007291	1/92	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG88KTR1	GO:0006470	1/92	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG88KTR1	GO:0005795	1/92	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG88KTR1	GO:0004672	1/92	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG88KTR1	GO:0016314	1/92	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	molecular_function	"Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67]
EOG88KTR1	GO:0008138	1/92	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG88KTR1	GO:0016191	1/92	synaptic vesicle uncoating	biological_process	"The removal of the protein coat on a synaptic vesicle." [GOC:curators, PMID:10099709]
EOG88KTR1	GO:0007219	1/92	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG88KTR1	GO:0006468	1/92	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG88KTR2	GO:0035859	1/89	Seh1-associated complex	cellular_component	"A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883, PMID:23974112]
EOG88KTR2	GO:0004402	1/89	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8PCD69	GO:0008270	29/157	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PCD69	GO:0003677	2/157	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8PCD69	GO:0001047	1/157	core promoter binding	molecular_function	"Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH]
EOG8PCD69	GO:0006338	1/157	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG8PCD69	GO:0005704	1/157	polytene chromosome band	cellular_component	"A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342]
EOG8PCD69	GO:0032440	1/157	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8PCD69	GO:0035102	1/157	PRC1 complex	cellular_component	"A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979]
EOG8PCD69	GO:0005725	1/157	intercalary heterochromatin	cellular_component	"Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245]
EOG8PCD69	GO:0006342	1/157	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG8PCD69	GO:0005634	1/157	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PCD69	GO:0007411	1/157	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8PCD69	GO:0035186	1/157	syncytial blastoderm mitotic cell cycle	biological_process	"Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238]
EOG8QRKJV	GO:0071011	1/82	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8QRKJV	GO:0000398	1/82	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8PRW50	GO:0005245	1/281	voltage-gated calcium channel activity	molecular_function	"Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
EOG8PRW50	GO:0045886	1/281	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8PRW50	GO:0048488	1/281	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8PRW50	GO:0019233	1/281	sensory perception of pain	biological_process	"The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [http://www.onelook.com/]
EOG8PRW50	GO:0045202	1/281	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8PRW50	GO:0048786	1/281	presynaptic active zone	cellular_component	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
EOG8PRW50	GO:0007528	1/281	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8PRW50	GO:0070588	1/281	calcium ion transmembrane transport	biological_process	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8PRW50	GO:0007274	1/281	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8PRW52	GO:0005089	16/67	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8PRW52	GO:0035556	11/67	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8PRW52	GO:0005524	4/67	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8PRW52	GO:0004674	2/67	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8PRW52	GO:0004713	1/67	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8PRW52	GO:0004672	1/67	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8PRW52	GO:0004683	1/67	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG8XH2DT	GO:0016021	4/42	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PRW55	GO:0003676	6/83	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8PRW56	GO:0003743	21/87	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8PRW56	GO:0006417	1/87	regulation of translation	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8577MX	GO:0016021	75/289	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8577MX	GO:0006486	74/289	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8577MX	GO:0005794	73/289	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8577MX	GO:0046872	72/289	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8577MX	GO:0016757	70/289	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8577MX	GO:0004653	9/289	polypeptide N-acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595]
EOG8577MX	GO:0000139	3/289	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8577MX	GO:0005795	2/289	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG8577MX	GO:0009312	2/289	oligosaccharide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]
EOG8577MX	GO:0006493	1/289	protein O-linked glycosylation	biological_process	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]
EOG8577MX	GO:0033628	1/289	regulation of cell adhesion mediated by integrin	biological_process	"Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add]
EOG8577MX	GO:0070278	1/289	extracellular matrix constituent secretion	biological_process	"The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah]
EOG8577MX	GO:0031589	1/289	cell-substrate adhesion	biological_process	"The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf]
EOG8577MX	GO:0032504	1/289	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8577MX	GO:0008376	1/289	acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]
EOG8577MX	GO:0016266	1/289	O-glycan processing	biological_process	"The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure." [GOC:mah, GOC:pr, PMID:10580130]
EOG8PCD6Q	GO:0004842	23/96	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8QRKJ0	GO:0008270	49/217	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8QRKJ0	GO:0016740	1/217	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8577MP	GO:0006511	26/94	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8577MP	GO:0008234	18/94	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8577MP	GO:0008233	3/94	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8577MP	GO:0016579	1/94	protein deubiquitination	biological_process	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]
EOG8577MP	GO:0004221	1/94	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG88KTRR	GO:0000502	4/87	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG88KTRR	GO:0008541	1/87	proteasome regulatory particle, lid subcomplex	cellular_component	"The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb]
EOG88KTRR	GO:0043161	1/87	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG88KTRR	GO:0005838	1/87	proteasome regulatory particle	cellular_component	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]
EOG88KTRR	GO:0005515	1/87	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG88KTRR	GO:0006508	1/87	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8PRW5Q	GO:0006351	25/83	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8PRW5Q	GO:0003899	24/83	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8PRW5Q	GO:0003677	18/83	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8PRW5Q	GO:0005703	1/83	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG8PRW5Q	GO:0034605	1/83	cellular response to heat	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]
EOG8PRW5Q	GO:0006366	1/83	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8PRW5Q	GO:0005737	1/83	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8PRW5Q	GO:0005875	1/83	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8PRW5Q	GO:0005665	1/83	DNA-directed RNA polymerase II, core complex	cellular_component	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8PRW5Q	GO:0005634	1/83	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PCD6H	GO:0000049	30/94	tRNA binding	molecular_function	"Interacting selectively and non-covalently with transfer RNA." [GOC:ai]
EOG8PCD6H	GO:0005737	30/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8PCD6H	GO:0005524	30/94	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8PCD6H	GO:0004826	25/94	phenylalanine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]
EOG8PCD6H	GO:0006432	25/94	phenylalanyl-tRNA aminoacylation	biological_process	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8PCD6H	GO:0004812	5/94	aminoacyl-tRNA ligase activity	molecular_function	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
EOG8PCD6H	GO:0043039	3/94	tRNA aminoacylation	biological_process	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]
EOG8PCD6H	GO:0006418	2/94	tRNA aminoacylation for protein translation	biological_process	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]
EOG8C5G07	GO:0004252	2199/5565	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8C5G07	GO:0006508	98/5565	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8C5G07	GO:0005615	18/5565	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8C5G07	GO:0005576	17/5565	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8C5G07	GO:0007586	11/5565	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG8C5G07	GO:0004175	8/5565	endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8C5G07	GO:0016021	6/5565	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C5G07	GO:0016787	5/5565	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8C5G07	GO:0016301	5/5565	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8C5G07	GO:0008236	5/5565	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8C5G07	GO:0045087	4/5565	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8C5G07	GO:0006629	4/5565	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8C5G07	GO:0006952	3/5565	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8C5G07	GO:0045752	3/5565	positive regulation of Toll signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8C5G07	GO:0050830	3/5565	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG8C5G07	GO:0008063	3/5565	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8C5G07	GO:0008233	3/5565	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8C5G07	GO:0005829	3/5565	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8C5G07	GO:0008889	3/5565	glycerophosphodiester phosphodiesterase activity	molecular_function	"Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]
EOG8C5G07	GO:0006071	3/5565	glycerol metabolic process	biological_process	"The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]
EOG8C5G07	GO:0050832	3/5565	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8C5G07	GO:0022008	2/5565	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8C5G07	GO:0050829	2/5565	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8C5G07	GO:0009950	2/5565	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8C5G07	GO:0035006	2/5565	melanization defense response	biological_process	"The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809]
EOG8C5G07	GO:0007311	2/5565	maternal specification of dorsal/ventral axis, oocyte, germ-line encoded	biological_process	"Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8C5G07	GO:0031638	2/5565	zymogen activation	biological_process	"The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd]
EOG8C5G07	GO:0008270	1/5565	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8C5G07	GO:0006964	1/5565	positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
EOG8C5G07	GO:0005515	1/5565	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8C5G07	GO:0005622	1/5565	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8C5G07	GO:0004435	1/5565	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8C5G07	GO:0048812	1/5565	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8C5G07	GO:0008592	1/5565	regulation of Toll signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8C5G07	GO:0006967	1/5565	positive regulation of antifungal peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah]
EOG8C5G07	GO:0003964	1/5565	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8C5G07	GO:0035008	1/5565	positive regulation of melanization defense response	biological_process	"Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf]
EOG8C5G07	GO:0035007	1/5565	regulation of melanization defense response	biological_process	"Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf]
EOG8C5G07	GO:0035556	1/5565	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8C5G07	GO:0003723	1/5565	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8C5G07	GO:0005581	1/5565	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8C5G07	GO:0004930	1/5565	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8C5G07	GO:0006909	1/5565	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8C5G07	GO:0004180	1/5565	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8C5G07	GO:0006959	1/5565	humoral immune response	biological_process	"An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]
EOG8C5G07	GO:0004471	1/5565	malate dehydrogenase (decarboxylating) (NAD+) activity	molecular_function	"Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39]
EOG8C5G07	GO:0016485	1/5565	protein processing	biological_process	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]
EOG8C5G07	GO:0003677	1/5565	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8C5G07	GO:0051287	1/5565	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8C5G07	GO:0042060	1/5565	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG81ZHS3	GO:0003723	25/88	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG81ZHS3	GO:0009982	25/88	pseudouridine synthase activity	molecular_function	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]
EOG81ZHS3	GO:0001522	25/88	pseudouridine synthesis	biological_process	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]
EOG81ZHS3	GO:0008033	22/88	tRNA processing	biological_process	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]
EOG81ZHS3	GO:0016829	1/88	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8C5G03	GO:0003779	2/344	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8C5G03	GO:0006936	1/344	muscle contraction	biological_process	"A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]
EOG8C5G03	GO:0051015	1/344	actin filament binding	molecular_function	"Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]
EOG8C5G03	GO:0048477	1/344	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8C5G03	GO:0007507	1/344	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8C5G03	GO:0030017	1/344	sarcomere	cellular_component	"The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]
EOG8C5G03	GO:0010591	1/344	regulation of lamellipodium assembly	biological_process	"Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG8C5G03	GO:0070865	1/344	investment cone	cellular_component	"A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization." [GOC:sart, PMID:15829565, PMID:9550716]
EOG8C5G03	GO:0045451	1/344	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8C5G03	GO:0007315	1/344	pole plasm assembly	biological_process	"Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8C5G03	GO:0048813	1/344	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG81ZHS9	GO:0033557	16/86	Slx1-Slx4 complex	cellular_component	"A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377]
EOG81ZHS9	GO:0006281	16/86	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG81ZHS9	GO:0006310	16/86	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG81ZHS9	GO:0017108	16/86	5'-flap endonuclease activity	molecular_function	"Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254]
EOG81ZHS9	GO:0046872	14/86	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81ZHS9	GO:0005515	1/86	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG81ZHS9	GO:0007095	1/86	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG81ZHS9	GO:0008270	1/86	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8S4RZ7	GO:0046872	2/11	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8S4RZ7	GO:0003676	1/11	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85XBD5	GO:0005509	62/282	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG85XBD5	GO:0048190	1/282	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG85XBD5	GO:0048812	1/282	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8QVFS0	GO:0000166	27/89	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8QVFS0	GO:0003676	26/89	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QVFS0	GO:0008152	1/89	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8QVFS0	GO:0004386	1/89	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8QVFS0	GO:0003729	1/89	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8B2WC4	GO:0003964	1/24	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8B2WC4	GO:0003676	1/24	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8B2WC4	GO:0003723	1/24	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8B2WC9	GO:0008270	24/84	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8B2WC9	GO:0005634	23/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8B2WC9	GO:0030496	1/84	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG8B2WC9	GO:0005730	1/84	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8B2WC9	GO:0000775	1/84	chromosome, centromeric region	cellular_component	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
EOG8J3ZZQ	GO:0005856	25/85	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8J3ZZQ	GO:0030833	25/85	regulation of actin filament polymerization	biological_process	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG8J3ZZQ	GO:0030027	1/85	lamellipodium	cellular_component	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]
EOG8J3ZZQ	GO:0003779	1/85	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8J3ZZQ	GO:0005515	1/85	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8J3ZZQ	GO:0006909	1/85	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8J3ZZQ	GO:0000902	1/85	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG87M4CW	GO:0008270	37/166	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87M4CW	GO:0016491	33/166	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG87M4CW	GO:0003960	3/166	NADPH:quinone reductase activity	molecular_function	"Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5]
EOG87M4CW	GO:0047522	1/166	15-oxoprostaglandin 13-oxidase activity	molecular_function	"Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, KEGG:R04556, KEGG:R04557, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN]
EOG87M4CW	GO:0036132	1/166	13-prostaglandin reductase activity	molecular_function	"Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin." [EC:1.3.1.48, GOC:mw, KEGG:R04556, KEGG:R04557, PMID:17449869]
EOG88SK74	GO:0000398	1/92	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG88SK74	GO:0071013	1/92	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG88SK74	GO:0004402	1/92	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG88SK74	GO:0005681	1/92	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG88SK74	GO:0071011	1/92	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8616JB	GO:0022857	20/63	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8616JB	GO:0016021	20/63	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VMHXJ	GO:0020037	88/334	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8VMHXJ	GO:0046872	70/334	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8VMHXJ	GO:0009703	3/334	nitrate reductase (NADH) activity	molecular_function	"Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+." [EC:1.7.1.1]
EOG8VMHXJ	GO:0045610	1/334	regulation of hemocyte differentiation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG8VMHXJ	GO:0005789	1/334	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8VMHXJ	GO:0055114	1/334	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8VMHXJ	GO:0003723	1/334	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8VMHXJ	GO:0016021	1/334	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VMHXJ	GO:0035206	1/334	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8VMHXJ	GO:0005811	1/334	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG88SK79	GO:0005524	27/87	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88SK79	GO:0015991	26/87	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG88SK79	GO:0016820	26/87	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	molecular_function	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]
EOG88SK79	GO:0046034	25/87	ATP metabolic process	biological_process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]
EOG88SK79	GO:0033180	23/87	proton-transporting V-type ATPase, V1 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG88SK79	GO:0033178	2/87	proton-transporting two-sector ATPase complex, catalytic domain	cellular_component	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056]
EOG88SK79	GO:0007035	1/87	vacuolar acidification	biological_process	"Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid]
EOG88SK79	GO:0048471	1/87	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG88SK79	GO:0005903	1/87	brush border	cellular_component	"Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194]
EOG88SK79	GO:0033181	1/87	plasma membrane proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
EOG88SK79	GO:0000221	1/87	vacuolar proton-transporting V-type ATPase, V1 domain	cellular_component	"The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG88SK79	GO:0005886	1/87	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG88SK79	GO:0005769	1/87	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG8616JJ	GO:0007076	3/75	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8616JJ	GO:0000796	3/75	condensin complex	cellular_component	"A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
EOG8616JJ	GO:0005874	1/75	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8616JJ	GO:0000226	1/75	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8XWJCZ	GO:0003824	18/88	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8XWJCZ	GO:0016740	3/88	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8XWJCZ	GO:0004663	2/88	Rab geranylgeranyltransferase activity	molecular_function	"Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375]
EOG8XWJCZ	GO:0008152	1/88	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8XWJCZ	GO:0004662	1/88	CAAX-protein geranylgeranyltransferase activity	molecular_function	"Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375]
EOG8XWJCZ	GO:0004661	1/88	protein geranylgeranyltransferase activity	molecular_function	"Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375]
EOG8XWJCZ	GO:0022008	1/88	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8XWJCZ	GO:0035050	1/88	embryonic heart tube development	biological_process	"The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
EOG8616JW	GO:0016491	19/97	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8VMHXZ	GO:0003723	26/80	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8VMHXZ	GO:0008270	26/80	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VMHXZ	GO:0006378	1/80	mRNA polyadenylation	biological_process	"The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]
EOG8VMHXZ	GO:0007314	1/80	oocyte anterior/posterior axis specification	biological_process	"Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8VMHXZ	GO:0042078	1/80	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG8VMHXZ	GO:0008354	1/80	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8VMHXZ	GO:0017148	1/80	negative regulation of translation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8VMHXZ	GO:0045495	1/80	pole plasm	cellular_component	"Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380]
EOG8VMHXZ	GO:0007283	1/80	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8VMHXZ	GO:0030718	1/80	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8VMHXZ	GO:0007281	1/80	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8VMHXZ	GO:0035282	1/80	segmentation	biological_process	"The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689]
EOG8VMHXZ	GO:0008595	1/80	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8VMHXZ	GO:0016321	1/80	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8VMHXZ	GO:0048477	1/80	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8VMHXZ	GO:0043066	1/80	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8VMHXZ	GO:0007280	1/80	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG8VMHXZ	GO:0048134	1/80	germ-line cyst formation	biological_process	"Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920]
EOG8VMHXZ	GO:0045892	1/80	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8VMHXZ	GO:0048813	1/80	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8VMHXZ	GO:0005515	1/80	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VMHXZ	GO:0001709	1/80	cell fate determination	biological_process	"A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
EOG8XWJC5	GO:0000932	1/90	cytoplasmic mRNA processing body	cellular_component	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603]
EOG8XWJC5	GO:0005875	1/90	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8XWJC5	GO:0006402	1/90	mRNA catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]
EOG8XWJC5	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG83XXMT	GO:0003676	3/277	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83XXMT	GO:0015074	2/277	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG83XXMT	GO:0003678	1/277	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG83XXMT	GO:0000723	1/277	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG83XXMT	GO:0006281	1/277	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG83N9W7	GO:0008073	18/76	ornithine decarboxylase inhibitor activity	molecular_function	"The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase." [GOC:jl]
EOG83N9W7	GO:0007275	1/76	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8616J9	GO:0003677	11/71	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8616J9	GO:0004518	10/71	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8616J9	GO:0004527	1/71	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG86X1SG	GO:0017176	5/27	phosphatidylinositol N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]
EOG8QNQC4	GO:0006811	2/32	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8QNQC4	GO:0005921	2/32	gap junction	cellular_component	"A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181]
EOG8QNQC4	GO:0016021	1/32	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QVFSR	GO:0003677	27/92	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8B2WCM	GO:0005524	27/183	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8B2WCM	GO:0004363	27/183	glutathione synthase activity	molecular_function	"Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate." [EC:6.3.2.3, RHEA:13560]
EOG8B2WCM	GO:0006974	2/183	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8B2WCM	GO:0071722	2/183	detoxification of arsenic-containing substance	biological_process	"Any process that reduces or removes the toxicity of compounds containing arsenic, including arsenates, arsenites, and arsenides. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of arsenic or arsenic-containing compounds." [GOC:kmv, PMID:11313333, PMID:20221439]
EOG80S2VH	GO:0005198	26/94	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG80S2VH	GO:0006886	26/94	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG80S2VH	GO:0016192	26/94	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG80S2VH	GO:0030126	23/94	COPI vesicle coat	cellular_component	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]
EOG80S2VH	GO:0030117	3/94	membrane coat	cellular_component	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]
EOG80S2VH	GO:0007112	1/94	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG80S2VH	GO:0016905	1/94	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG80S2VH	GO:0004402	1/94	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG80S2VH	GO:0010883	1/94	regulation of lipid storage	biological_process	"Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
EOG80S2VH	GO:0000902	1/94	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG80S2VH	GO:0006909	1/94	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG80S2VH	GO:0048812	1/94	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG80GG71	GO:0003676	20/947	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80GG71	GO:0008270	20/947	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80GG71	GO:0003677	3/947	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80GG71	GO:0005634	3/947	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80GG71	GO:0004190	2/947	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG80GG71	GO:0003964	2/947	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG80GG71	GO:0003723	2/947	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG80GG71	GO:0000786	1/947	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG80GG71	GO:0015074	1/947	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG80GG71	GO:0004812	1/947	aminoacyl-tRNA ligase activity	molecular_function	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
EOG80GG71	GO:0006334	1/947	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8KH591	GO:0031011	19/81	Ino80 complex	cellular_component	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820]
EOG8KH591	GO:0008270	1/81	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KH591	GO:0003676	1/81	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG883GM7	GO:0008137	27/76	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG883GM7	GO:0005739	22/76	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG883GM7	GO:0006120	5/76	mitochondrial electron transport, NADH to ubiquinone	biological_process	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363]
EOG883GM7	GO:0005747	5/76	mitochondrial respiratory chain complex I	cellular_component	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]
EOG8TTK0Q	GO:0008270	24/79	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TTK0Q	GO:0003677	2/79	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TTK0Q	GO:0005634	2/79	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TTK0Q	GO:0007005	1/79	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8TTK0Q	GO:0006470	1/79	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8TTK0Q	GO:0048565	1/79	digestive tract development	biological_process	"The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators]
EOG8TTK0Q	GO:0005886	1/79	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8TTK0Q	GO:0035335	1/79	peptidyl-tyrosine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
EOG8TTK0Q	GO:0051046	1/79	regulation of secretion	biological_process	"Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
EOG8TTK0Q	GO:0030382	1/79	sperm mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144]
EOG8TTK0Q	GO:0005737	1/79	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8TTK0Q	GO:0004725	1/79	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8TTK0D	GO:0003676	1/28	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82NMDD	GO:0050807	15/87	regulation of synapse organization	biological_process	"Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]
EOG82NMDD	GO:0016567	15/87	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG82NMDD	GO:0016049	15/87	cell growth	biological_process	"The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]
EOG82NMDD	GO:0030955	2/87	potassium ion binding	molecular_function	"Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah]
EOG82NMDD	GO:0000287	2/87	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG82NMDD	GO:0004743	2/87	pyruvate kinase activity	molecular_function	"Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40]
EOG82NMDD	GO:0006096	2/87	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG82NMDD	GO:0003779	1/87	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG82NMDD	GO:0048812	1/87	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG82NMD4	GO:0045177	1/151	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG82NMD4	GO:0030424	1/151	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG82NMD4	GO:0005938	1/151	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG82NMD4	GO:0035316	1/151	non-sensory hair organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis." [GOC:mtg_sensu, PMID:11064425]
EOG82NMD4	GO:0035317	1/151	imaginal disc-derived wing hair organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853]
EOG82NMD4	GO:0045860	1/151	positive regulation of protein kinase activity	biological_process	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
EOG82NMD4	GO:0044297	1/151	cell body	cellular_component	"The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]
EOG82NMD4	GO:0005515	1/151	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG82NMD4	GO:0048800	1/151	antennal morphogenesis	biological_process	"The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid]
EOG82NMD4	GO:0030425	1/151	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG82NMD4	GO:0050773	1/151	regulation of dendrite development	biological_process	"Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai]
EOG82NMD4	GO:0008407	1/151	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG82NMD4	GO:0007476	1/151	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG82NMD4	GO:0048601	1/151	oocyte morphogenesis	biological_process	"The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators]
EOG82NMD4	GO:0042052	1/151	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG82NMD4	GO:0005737	1/151	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82NMD4	GO:0070593	1/151	dendrite self-avoidance	biological_process	"The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551]
EOG82NMD4	GO:0048814	1/151	regulation of dendrite morphogenesis	biological_process	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG82NMD4	GO:0045893	1/151	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82NMD4	GO:0006351	1/151	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8F20JC	GO:0016021	27/81	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F20JC	GO:0005789	1/81	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8F20JC	GO:0046331	1/81	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8F20JC	GO:0045169	1/81	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG869T97	GO:0006412	24/81	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG869T97	GO:0003735	24/81	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG869T97	GO:0005840	23/81	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG869T97	GO:0005763	1/81	mitochondrial small ribosomal subunit	cellular_component	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
EOG8KH59F	GO:0042052	1/98	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8KH59F	GO:0031468	1/98	nuclear envelope reassembly	biological_process	"The reformation of the nuclear envelope following its breakdown in the context of a normal process." [GOC:mah]
EOG8W6RD1	GO:0003676	26/237	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W6RD1	GO:0008270	25/237	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8W6RD1	GO:0003677	1/237	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8W6RD1	GO:0004523	1/237	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8W6RD1	GO:0003964	1/237	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8W6RD1	GO:0003723	1/237	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8GQSM3	GO:0005524	25/84	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8GQSM3	GO:0016773	24/84	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8GQSM3	GO:0004849	24/84	uridine kinase activity	molecular_function	"Catalysis of the reaction: ATP + uridine = ADP + UMP." [EC:2.7.1.48]
EOG8GQSM3	GO:0016301	1/84	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8GQSM3	GO:0044211	1/84	CTP salvage	biological_process	"Any process which produces cytidine 5'-triphosphate (CTP) from derivatives of it, without de novo synthesis." [GOC:ecd, GOC:jl, PMID:10501935]
EOG8GQSM3	GO:0044206	1/84	UMP salvage	biological_process	"Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis." [GOC:ecd, PMID:15096496]
EOG8GQSM3	GO:0006909	1/84	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG89626T	GO:0003824	6/118	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG89626T	GO:0016787	3/118	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG89626T	GO:0052689	1/118	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG89626T	GO:0005811	1/118	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG89626T	GO:0008152	1/118	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG89626T	GO:0004177	1/118	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG89626S	GO:0006555	20/85	methionine metabolic process	biological_process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
EOG89626S	GO:0035999	20/85	tetrahydrofolate interconversion	biological_process	"The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999, UniPathway:UPA00193]
EOG89626S	GO:0004489	20/85	methylenetetrahydrofolate reductase (NAD(P)H) activity	molecular_function	"Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20]
EOG8FFGGV	GO:0005739	1/77	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8FFGGV	GO:0006390	1/77	transcription from mitochondrial promoter	biological_process	"The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl]
EOG8NCPWD	GO:0005747	21/73	mitochondrial respiratory chain complex I	cellular_component	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]
EOG8NCPWD	GO:0048244	1/73	phytanoyl-CoA dioxygenase activity	molecular_function	"Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate." [EC:1.14.11.18, RHEA:16068]
EOG8RZ1F9	GO:0022008	1/86	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8PK4R6	GO:0005509	1/26	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8RZ1F6	GO:0051301	3/96	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8RZ1F6	GO:0007067	1/96	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8RZ1F6	GO:0003755	1/96	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8RZ1F6	GO:0000278	1/96	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8RZ1F6	GO:0022008	1/96	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8RZ1F6	GO:0030071	1/96	regulation of mitotic metaphase/anaphase transition	biological_process	"Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle." [GOC:mah]
EOG8RZ1F6	GO:0090302	1/96	APC-Cdc20 complex activity	molecular_function	"A ubiquitin-protein ligase activity that increases the rate or extent of the metaphase to anaphase transition of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
EOG8RZ1F6	GO:0006457	1/96	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8RZ1F6	GO:0045842	1/96	positive regulation of mitotic metaphase/anaphase transition	biological_process	"Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
EOG82JR65	GO:0000166	25/85	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG82JR65	GO:0046872	25/85	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82JR65	GO:0003723	24/85	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG82JR65	GO:0000398	1/85	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG82JR65	GO:0071013	1/85	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG82JR65	GO:0005634	1/85	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82JR65	GO:0003729	1/85	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG82JR65	GO:0071011	1/85	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG82JR65	GO:0000381	1/85	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8CG2R8	GO:0003676	293/3952	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CG2R8	GO:0015074	167/3952	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8CG2R8	GO:0008270	165/3952	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CG2R8	GO:0003723	66/3952	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CG2R8	GO:0003964	66/3952	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8CG2R8	GO:0004190	48/3952	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8CG2R8	GO:0005634	3/3952	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CG2R8	GO:0005509	3/3952	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8CG2R8	GO:0003677	3/3952	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CG2R8	GO:0016021	2/3952	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CG2R8	GO:0007166	2/3952	cell surface receptor signaling pathway	biological_process	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
EOG8CG2R8	GO:0004842	2/3952	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8CG2R8	GO:0023051	2/3952	regulation of signaling	biological_process	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
EOG8CG2R8	GO:0046872	2/3952	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CG2R8	GO:0004871	2/3952	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8CG2R8	GO:0003700	1/3952	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8CG2R8	GO:0016620	1/3952	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG8CG2R8	GO:0004527	1/3952	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8CG2R8	GO:0005524	1/3952	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CG2R8	GO:0055085	1/3952	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8CG2R8	GO:0043565	1/3952	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8CG2R8	GO:0004518	1/3952	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8CG2R8	GO:0004672	1/3952	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8CG2R8	GO:0004725	1/3952	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8CG2R8	GO:0005840	1/3952	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8CG2R8	GO:0006412	1/3952	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8CG2R8	GO:0022857	1/3952	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8CG2R8	GO:0019031	1/3952	viral envelope	cellular_component	"The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope]
EOG8CG2R8	GO:0003735	1/3952	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8CG2R8	GO:0016491	1/3952	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8CG2R8	GO:0005975	1/3952	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8HMMQC	GO:0004871	1/83	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8HMMQC	GO:0046331	1/83	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8HMMQC	GO:0008587	1/83	imaginal disc-derived wing margin morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG8HMMQC	GO:0048749	1/83	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8HMMQC	GO:0016318	1/83	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG8HMMQC	GO:0005770	1/83	late endosome	cellular_component	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
EOG8HMMQC	GO:0007460	1/83	R8 cell fate commitment	biological_process	"The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883]
EOG8HMMQC	GO:0005576	1/83	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8HMMQC	GO:0007219	1/83	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8HMMQC	GO:0016321	1/83	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8HMMQC	GO:0045468	1/83	regulation of R8 cell spacing in compound eye	biological_process	"Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc." [GOC:dph, GOC:tb, PMID:11880339]
EOG8HMMQC	GO:0097305	1/83	response to alcohol	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [CHEBI:30879, GOC:pr]
EOG8STVK9	GO:0001522	25/81	pseudouridine synthesis	biological_process	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]
EOG8STVK9	GO:0042254	25/81	ribosome biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
EOG8STVK9	GO:0005524	4/81	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8STVK9	GO:0004672	3/81	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8STVK9	GO:0006364	1/81	rRNA processing	biological_process	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
EOG8STVK9	GO:0004674	1/81	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8STVK9	GO:0005732	1/81	small nucleolar ribonucleoprotein complex	cellular_component	"A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8STVK9	GO:0003723	1/81	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8STVK9	GO:0022008	1/81	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8STVK9	GO:0005576	1/81	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8STVK9	GO:0005634	1/81	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8STVK9	GO:0016772	1/81	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8BVV99	GO:0046872	1/19	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HMMQG	GO:0046872	2/95	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CG2RX	GO:0005737	1/83	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CG2RX	GO:0022008	1/83	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8S1WPX	GO:0046872	2/20	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z91FN	GO:0008270	1/15	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8H48KQ	GO:0003682	1/15	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8BK7JK	GO:0005669	31/96	transcription factor TFIID complex	cellular_component	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]
EOG8BK7JK	GO:0006367	31/96	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG8BK7JK	GO:0003743	4/96	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8BK7JK	GO:0051123	1/96	RNA polymerase II transcriptional preinitiation complex assembly	biological_process	"The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:10882737, PMID:15020047]
EOG8BK7JK	GO:0003700	1/96	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8BK7JK	GO:0005634	1/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BK7JK	GO:0006355	1/96	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8HTC6W	GO:0000398	1/83	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8HTC6W	GO:0046854	1/83	phosphatidylinositol phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]
EOG8HTC6W	GO:0071011	1/83	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8HTC6V	GO:0016021	121/277	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HTC6V	GO:0032580	121/277	Golgi cisterna membrane	cellular_component	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]
EOG8HTC6V	GO:0006486	121/277	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8HTC6V	GO:0008417	116/277	fucosyltransferase activity	molecular_function	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
EOG8HTC6V	GO:0017060	3/277	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	molecular_function	"Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.65]
EOG8HTC6V	GO:0018392	3/277	glycoprotein 3-alpha-L-fucosyltransferase activity	molecular_function	"Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H(+)." [EC:2.4.1.214, RHEA:24447]
EOG8HTC6V	GO:0005797	1/277	Golgi medial cisterna	cellular_component	"The middle Golgi cisterna (or cisternae)." [ISBN:0815316194]
EOG8HTC6V	GO:0033932	1/277	1,3-alpha-L-fucosidase activity	molecular_function	"Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins." [EC:3.2.1.111]
EOG8HTC6V	GO:0046920	1/277	alpha-(1->3)-fucosyltransferase activity	molecular_function	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]
EOG8HTC6V	GO:0007399	1/277	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8HTC6V	GO:0036071	1/277	N-glycan fucosylation	biological_process	"The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains." [CHEBI:59520, GOC:sart, PMID:19948734]
EOG8BK7JN	GO:0003723	22/84	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8BK7JN	GO:0003735	11/84	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8BK7JN	GO:0006412	11/84	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8BK7JN	GO:0015934	10/84	large ribosomal subunit	cellular_component	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]
EOG8BK7JN	GO:0005739	10/84	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8BK7JN	GO:0005840	3/84	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8BK7JN	GO:0005762	1/84	mitochondrial large ribosomal subunit	cellular_component	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
EOG8BK7JN	GO:0006672	1/84	ceramide metabolic process	biological_process	"The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684]
EOG8BK7JN	GO:0016811	1/84	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]
EOG8BK7JN	GO:0016021	1/84	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89CSRP	GO:0005886	1/14	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG89CSRP	GO:0005578	1/14	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG89CSRP	GO:0031225	1/14	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG8BK7JB	GO:0003824	3/83	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8J3ZX0	GO:0005525	26/89	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8J3ZX0	GO:0003924	25/89	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8J3ZX0	GO:0050829	1/89	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8J3ZX0	GO:0045089	1/89	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8J3ZX0	GO:0004781	1/89	sulfate adenylyltransferase (ATP) activity	molecular_function	"Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4]
EOG8J3ZX0	GO:0005634	1/89	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8J3ZX0	GO:0003746	1/89	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG8J3ZX0	GO:0005737	1/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8MSGG0	GO:0005783	19/48	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8FN6XX	GO:0016773	1/87	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8FN6XX	GO:0022008	1/87	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8PCD7G	GO:0004535	2/102	poly(A)-specific ribonuclease activity	molecular_function	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]
EOG8PCD7G	GO:0048477	1/102	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8PCD7G	GO:0000289	1/102	nuclear-transcribed mRNA poly(A) tail shortening	biological_process	"Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc]
EOG8PCD7G	GO:0030014	1/102	CCR4-NOT complex	cellular_component	"The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins." [GOC:sart, PMID:11113136]
EOG8PCD7G	GO:0017148	1/102	negative regulation of translation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8PCD7G	GO:0006402	1/102	mRNA catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]
EOG8PCD7G	GO:0048132	1/102	female germ-line stem cell asymmetric division	biological_process	"The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu]
EOG8PCD7G	GO:0016020	1/102	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8PCD7G	GO:0005737	1/102	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG81NX2H	GO:0003677	2/69	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81NX2H	GO:0003676	2/69	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88D386	GO:0016021	1/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88D386	GO:0005524	1/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88D386	GO:0042626	1/91	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG80041M	GO:0004950	1/11	chemokine receptor activity	molecular_function	"Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, http://en.wikipedia.org/wiki/Chemokine, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823]
EOG80041M	GO:0006935	1/11	chemotaxis	biological_process	"The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732]
EOG80041M	GO:0016021	1/11	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HTC81	GO:0003676	1/11	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HTC81	GO:0046872	1/11	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8S7N5H	GO:0007264	24/80	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8S7N5H	GO:0005622	24/80	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8S7N5H	GO:0005525	24/80	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8S7N5H	GO:0003924	1/80	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8S7N5H	GO:0022008	1/80	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8S7N5H	GO:0016197	1/80	endosomal transport	biological_process	"The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]
EOG8S7N5H	GO:0006184	1/80	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8S7N5H	GO:0048488	1/80	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8S7N5H	GO:0007269	1/80	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8DJNCD	GO:0003743	25/78	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8DJNCD	GO:0000922	1/78	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8DJNCD	GO:0005815	1/78	microtubule organizing center	cellular_component	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416]
EOG8DJNCD	GO:0000226	1/78	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8J3ZXS	GO:0016012	24/91	sarcoglycan complex	cellular_component	"A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609]
EOG8J3ZXS	GO:0005509	16/91	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8577N6	GO:0005852	25/85	eukaryotic translation initiation factor 3 complex	cellular_component	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]
EOG8577N6	GO:0003743	25/85	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8577N6	GO:0016282	23/85	eukaryotic 43S preinitiation complex	cellular_component	"A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049]
EOG8577N6	GO:0001731	23/85	formation of translation preinitiation complex	biological_process	"The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd]
EOG8577N6	GO:0033290	23/85	eukaryotic 48S preinitiation complex	cellular_component	"A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049]
EOG8577N6	GO:0006413	1/85	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG8577N6	GO:0045747	1/85	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8577N6	GO:0022008	1/85	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8577N6	GO:0005829	1/85	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8577N0	GO:0003887	25/85	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8577N0	GO:0003677	25/85	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8577N0	GO:0005634	15/85	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8577N0	GO:0005635	1/85	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG8577N0	GO:0046982	1/85	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8577N0	GO:0006261	1/85	DNA-dependent DNA replication	biological_process	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]
EOG8577N0	GO:0006270	1/85	DNA replication initiation	biological_process	"The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194]
EOG8577N0	GO:0005658	1/85	alpha DNA polymerase:primase complex	cellular_component	"A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402]
EOG8DBWX0	GO:0003723	15/68	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG85MQM7	GO:0005057	25/93	receptor signaling protein activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf]
EOG85MQM7	GO:0005524	25/93	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG85MQM7	GO:0004674	25/93	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG85MQM7	GO:0046872	24/93	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85MQM7	GO:0008284	1/93	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG85MQM7	GO:0008069	1/93	dorsal/ventral axis specification, ovarian follicular epithelium	biological_process	"Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb]
EOG85MQM7	GO:0007476	1/93	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG85MQM7	GO:0009267	1/93	cellular response to starvation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]
EOG85MQM7	GO:0007173	1/93	epidermal growth factor receptor signaling pathway	biological_process	"A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933]
EOG85MQM7	GO:0046534	1/93	positive regulation of photoreceptor cell differentiation	biological_process	"Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
EOG85MQM7	GO:0008293	1/93	torso signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
EOG85MQM7	GO:0008586	1/93	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG85MQM7	GO:0007283	1/93	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG85MQM7	GO:0035309	1/93	wing and notum subfield formation	biological_process	"The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999]
EOG85MQM7	GO:0051726	1/93	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG85MQM7	GO:0004715	1/93	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG85MQM7	GO:0007362	1/93	terminal region determination	biological_process	"Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG85MQM7	GO:0030097	1/93	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG85MQM7	GO:0016772	1/93	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG85MQM7	GO:0046777	1/93	protein autophosphorylation	biological_process	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
EOG85MQM7	GO:0016242	1/93	negative regulation of macroautophagy	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]
EOG85MQM7	GO:0005515	1/93	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG85MQM7	GO:0007369	1/93	gastrulation	biological_process	"A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]
EOG85MQM7	GO:2001234	1/93	negative regulation of apoptotic signaling pathway	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]
EOG85MQM7	GO:0007298	1/93	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG85MQM7	GO:0002168	1/93	instar larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG85MQM7	GO:0007472	1/93	wing disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG85MQM7	GO:0007552	1/93	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG85MQM7	GO:0007428	1/93	primary branching, open tracheal system	biological_process	"Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG85MQM7	GO:0040014	1/93	regulation of multicellular organism growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG85MQM7	GO:0042386	1/93	hemocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723]
EOG85MQM7	GO:0035171	1/93	lamellocyte differentiation	biological_process	"The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104]
EOG85MQM7	GO:0007165	1/93	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8B2WDC	GO:0003677	3/350	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8B2WDC	GO:0004518	2/350	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8B2WDC	GO:0016747	1/350	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8B2WDC	GO:0004527	1/350	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8ZSCHK	GO:0050661	87/284	NADP binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]
EOG8ZSCHK	GO:0004499	87/284	N,N-dimethylaniline monooxygenase activity	molecular_function	"Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8]
EOG8ZSCHK	GO:0050660	87/284	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8ZSCHK	GO:0005789	9/284	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8ZSCHK	GO:0005829	2/284	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8ZSCHK	GO:0004497	2/284	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8ZSCHK	GO:0005739	2/284	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8ZSCHK	GO:0043231	2/284	intracellular membrane-bounded organelle	cellular_component	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
EOG8ZSCHK	GO:0016021	1/284	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZSCHK	GO:0016042	1/284	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8ZSCHK	GO:0045454	1/284	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8ZSCHK	GO:0003847	1/284	1-alkyl-2-acetylglycerophosphocholine esterase activity	molecular_function	"Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]
EOG8ZSCHT	GO:0008270	19/78	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VDSFV	GO:0046872	3/37	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QZB10	GO:0005549	4/130	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8QZB10	GO:0016021	4/130	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QZB10	GO:0004984	4/130	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8QZB10	GO:0004930	3/130	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8QZB10	GO:0016020	1/130	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QZB10	GO:0008527	1/130	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8QZB10	GO:0005886	1/130	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8ZSCHP	GO:0003676	128/391	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZSCHP	GO:0005634	126/391	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZSCHP	GO:0008270	126/391	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZSCHP	GO:0046872	28/391	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZSCHP	GO:0005739	24/391	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8ZSCHP	GO:0003677	23/391	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8ZSCHP	GO:0005840	3/391	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8ZSCHP	GO:0007349	1/391	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG8ZSCHP	GO:0045143	1/391	homologous chromosome segregation	biological_process	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194]
EOG8ZSCHP	GO:0007143	1/391	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8ZSCHP	GO:0007279	1/391	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8ZSCHP	GO:0006366	1/391	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8ZSCHP	GO:0006357	1/391	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8ZSCHP	GO:0007343	1/391	egg activation	biological_process	"The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751]
EOG8ZSCHP	GO:0000987	1/391	core promoter proximal region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8ZSCHP	GO:0045944	1/391	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG851H70	GO:0003677	26/83	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG851H70	GO:0005665	26/83	DNA-directed RNA polymerase II, core complex	cellular_component	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG851H70	GO:0003899	26/83	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG851H70	GO:0006351	25/83	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG851H70	GO:0007095	1/83	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG851H70	GO:0006360	1/83	transcription from RNA polymerase I promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
EOG851H70	GO:0006366	1/83	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG851H70	GO:0006383	1/83	transcription from RNA polymerase III promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH]
EOG851H70	GO:0005736	1/83	DNA-directed RNA polymerase I complex	cellular_component	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG851H70	GO:0005666	1/83	DNA-directed RNA polymerase III complex	cellular_component	"RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8CZDW8	GO:0005524	45/139	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CZDW8	GO:0008568	43/139	microtubule-severing ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766]
EOG8CZDW8	GO:0051013	43/139	microtubule severing	biological_process	"The process in which a microtubule is broken down into smaller segments." [GOC:ai, PMID:14657234]
EOG8CZDW8	GO:0005813	41/139	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8CZDW8	GO:0030496	41/139	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG8CZDW8	GO:0000922	41/139	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8CZDW8	GO:0005874	41/139	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8CZDW8	GO:0007126	41/139	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8CZDW8	GO:0005737	39/139	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CZDW8	GO:0008017	2/139	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8CZDW8	GO:0008352	2/139	katanin complex	cellular_component	"A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766]
EOG8CZDW8	GO:0007017	2/139	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8CZDW8	GO:0017111	1/139	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8CZDW8	GO:0031252	1/139	cell leading edge	cellular_component	"The area of a motile cell closest to the direction of movement." [GOC:pg]
EOG8CZDW8	GO:0005694	1/139	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8CZDW8	GO:0016358	1/139	dendrite development	biological_process	"The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8CZDW8	GO:0005938	1/139	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8CZDW8	GO:0070462	1/139	plus-end specific microtubule depolymerization	biological_process	"The removal of tubulin heterodimers from the plus end of a microtubule." [GOC:krc, PMID:16906145, PMID:16906148]
EOG8CZDW8	GO:0000070	1/139	mitotic sister chromatid segregation	biological_process	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
EOG8CZDW8	GO:0022416	1/139	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8CZDW8	GO:0005875	1/139	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8CZDW8	GO:0035220	1/139	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8CZDW8	GO:0050775	1/139	positive regulation of dendrite morphogenesis	biological_process	"Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG8CZDW8	GO:0017022	1/139	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8CZDW8	GO:0007019	1/139	microtubule depolymerization	biological_process	"The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194]
EOG8CZDW8	GO:0006200	1/139	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8CZDW8	GO:0031122	1/139	cytoplasmic microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
EOG8CZDW8	GO:0016322	1/139	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG8CZDW8	GO:0030336	1/139	negative regulation of cell migration	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]
EOG8CZDW8	GO:0008582	1/139	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG80S2WC	GO:0006629	148/439	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG80S2WC	GO:0005576	148/439	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG80S2WC	GO:0008970	88/439	phosphatidylcholine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32]
EOG80S2WC	GO:0016787	52/439	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG80S2WC	GO:0052739	12/439	phosphatidylserine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG:R04034]
EOG80S2WC	GO:0052740	12/439	1-acyl-2-lysophosphatidylserine acylhydrolase activity	molecular_function	"Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32]
EOG80S2WC	GO:0004806	11/439	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG80S2WC	GO:0003824	3/439	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG80S2WC	GO:0003676	1/439	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80S2WC	GO:0008270	1/439	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80S2WC	GO:0022008	1/439	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8C5G1W	GO:0006122	23/67	mitochondrial electron transport, ubiquinol to cytochrome c	biological_process	"The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]
EOG8C5G1W	GO:0005750	23/67	mitochondrial respiratory chain complex III	cellular_component	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684]
EOG8C5G1W	GO:0007286	1/67	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG8C5G1W	GO:0008121	1/67	ubiquinol-cytochrome-c reductase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]
EOG851H7K	GO:0008270	31/275	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG851H7K	GO:0003676	5/275	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG851H7K	GO:0003677	2/275	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG851H7K	GO:0016021	1/275	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG851H7K	GO:0015074	1/275	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG851H7K	GO:0005634	1/275	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG851H7K	GO:0004803	1/275	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG851H7K	GO:0004518	1/275	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG851H7K	GO:0055085	1/275	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG851H7K	GO:0006313	1/275	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG8CZDWC	GO:0003676	14/55	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CZDWC	GO:0046872	14/55	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CZDWC	GO:0048813	1/55	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8CZDWC	GO:0007411	1/55	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8CZDWC	GO:0048666	1/55	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8CZDWM	GO:0005234	18/66	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8CZDWM	GO:0004970	17/66	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8CZDWM	GO:0016020	15/66	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CZDWM	GO:0016021	3/66	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CZDWM	GO:0034220	1/66	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8CZDWM	GO:0036081	1/66	extracellular ammonia-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
EOG8CZDWM	GO:0071683	1/66	sensory dendrite	cellular_component	"A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron." [GOC:dos, GOC:kmv, GOC:mah]
EOG8CZDWM	GO:0015276	1/66	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8CZDWM	GO:0043235	1/66	receptor complex	cellular_component	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]
EOG8CZDWM	GO:0071229	1/66	cellular response to acid chemical	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:mah, http://en.wikipedia.org/wiki/Acid]
EOG8CZDWM	GO:0050907	1/66	detection of chemical stimulus involved in sensory perception	biological_process	"The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
EOG8VDSF4	GO:0035162	1/80	embryonic hemopoiesis	biological_process	"The stages of blood cell formation that take place within the embryo." [GOC:bf]
EOG8VDSF4	GO:0005769	1/80	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG8VDSF4	GO:0046425	1/80	regulation of JAK-STAT cascade	biological_process	"Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf]
EOG8VDSF4	GO:0005764	1/80	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8VDSF4	GO:0016021	1/80	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VDSF4	GO:0055037	1/80	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG8VDSF4	GO:0048542	1/80	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG8VDSF4	GO:0035167	1/80	larval lymph gland hemopoiesis	biological_process	"The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385]
EOG8VDSF4	GO:0005794	1/80	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8VDSF4	GO:0031410	1/80	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG8C5G1B	GO:0031083	1/56	BLOC-1 complex	cellular_component	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]
EOG8C5G1B	GO:0005515	1/56	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8C5G1B	GO:0008057	1/56	eye pigment granule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295]
EOG88SK86	GO:0004452	24/88	isopentenyl-diphosphate delta-isomerase activity	molecular_function	"Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate." [EC:5.3.3.2, RHEA:23287]
EOG88SK86	GO:0008299	24/88	isoprenoid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
EOG88SK86	GO:0016787	24/88	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8HDW8G	GO:0005737	27/96	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HDW8G	GO:0046654	27/96	tetrahydrofolate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]
EOG8HDW8G	GO:0003934	27/96	GTP cyclohydrolase I activity	molecular_function	"Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate." [EC:3.5.4.16]
EOG8HDW8G	GO:0043095	1/96	regulation of GTP cyclohydrolase I activity	biological_process	"Any process that modulates the activity of the enzyme GTP cyclohydrolase I." [GOC:jl]
EOG8HDW8G	GO:0009880	1/96	embryonic pattern specification	biological_process	"The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
EOG8HDW8G	GO:0006728	1/96	pteridine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732]
EOG8HDW8G	GO:0060308	1/96	GTP cyclohydrolase I regulator activity	molecular_function	"Modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate." [GOC:dph, GOC:tb]
EOG8HDW8G	GO:0035185	1/96	preblastoderm mitotic cell cycle	biological_process	"The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238]
EOG8HDW8G	GO:0005525	1/96	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8HDW8G	GO:0008363	1/96	larval chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG8HDW8G	GO:0035998	1/96	7,8-dihydroneopterin 3'-triphosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate." [CHEBI:18372, GOC:yaf, UniPathway:UPA00848]
EOG8HDW8G	GO:0048067	1/96	cuticle pigmentation	biological_process	"Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
EOG8HDW8G	GO:0046872	1/96	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HDW8G	GO:2000274	1/96	regulation of epithelial cell migration, open tracheal system	biological_process	"Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system." [GOC:obol]
EOG8HDW8G	GO:0048072	1/96	compound eye pigmentation	biological_process	"Establishment of a pattern of pigment in the compound eye." [GOC:jid]
EOG8HDW8G	GO:0006729	1/96	tetrahydrobiopterin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, GOC:go_curators, ISBN:0198506732]
EOG8QZB1Z	GO:0042302	27/131	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8ZSCH9	GO:0051536	25/90	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8ZSCH9	GO:0008080	23/90	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG8ZSCH9	GO:0004402	2/90	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8ZSCH9	GO:0016407	1/90	acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]
EOG8ZSCH9	GO:2000289	1/90	regulation of photoreceptor cell axon guidance	biological_process	"Any process that modulates the frequency, rate or extent of photoreceptor cell axon guidance." [GOC:mah]
EOG8ZSCH9	GO:0018394	1/90	peptidyl-lysine acetylation	biological_process	"The acetylation of peptidyl-lysine." [GOC:mah]
EOG8ZSCH9	GO:0006357	1/90	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8ZSCH9	GO:0008607	1/90	phosphorylase kinase regulator activity	molecular_function	"Modulation of the activity of the enzyme phosphorylase kinase." [EC:2.7.11.19]
EOG8ZSCH9	GO:0045202	1/90	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8ZSCH9	GO:0030431	1/90	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8ZSCH9	GO:0006351	1/90	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8ZSCH9	GO:0050808	1/90	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG8ZSCH9	GO:0051124	1/90	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8ZSCH9	GO:0005737	1/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZSCH9	GO:0008023	1/90	transcription elongation factor complex	cellular_component	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]
EOG8ZSCH9	GO:0045859	1/90	regulation of protein kinase activity	biological_process	"Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
EOG8ZSCH9	GO:0003824	1/90	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8ZSCH9	GO:0048789	1/90	cytoskeletal matrix organization at active zone	biological_process	"The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane." [GOC:dh, GOC:ef, GOC:jid, PMID:12812759]
EOG8ZSCH9	GO:0046872	1/90	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZSCH9	GO:0007626	1/90	locomotory behavior	biological_process	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
EOG85MQMN	GO:0070461	22/90	SAGA-type complex	cellular_component	"A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [GOC:mah, PMID:10637607, PMID:17337012]
EOG85MQMN	GO:0005634	2/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85MQMN	GO:0000124	2/90	SAGA complex	cellular_component	"A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012]
EOG8M3CQ8	GO:0004402	2/84	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG85MQMD	GO:0003676	21/89	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85MQMD	GO:0000213	21/89	tRNA-intron endonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9]
EOG85MQMD	GO:0006388	21/89	tRNA splicing, via endonucleolytic cleavage and ligation	biological_process	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]
EOG837TXR	GO:0003735	27/103	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG837TXR	GO:0006412	27/103	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG837TXR	GO:0005840	26/103	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG837TXR	GO:0005763	1/103	mitochondrial small ribosomal subunit	cellular_component	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
EOG837TXH	GO:0005576	6/76	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG837TXH	GO:0008061	6/76	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG837TXH	GO:0006030	6/76	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG837TXH	GO:0005201	1/76	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG837TXH	GO:0031012	1/76	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG837TXH	GO:0005581	1/76	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG85MQMR	GO:0003854	25/64	3-beta-hydroxy-delta5-steroid dehydrogenase activity	molecular_function	"Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]
EOG85MQMR	GO:0006694	25/64	steroid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]
EOG85MQMR	GO:0008460	15/64	dTDP-glucose 4,6-dehydratase activity	molecular_function	"Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O." [EC:4.2.1.46, RHEA:17224]
EOG85MQMR	GO:0009225	15/64	nucleotide-sugar metabolic process	biological_process	"The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]
EOG85MQMR	GO:0004769	3/64	steroid delta-isomerase activity	molecular_function	"Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid." [EC:5.3.3.1]
EOG85MQMR	GO:0050662	1/64	coenzyme binding	molecular_function	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
EOG85MQMR	GO:0045552	1/64	dihydrokaempferol 4-reductase activity	molecular_function	"Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+." [EC:1.1.1.219]
EOG85MQMR	GO:0044237	1/64	cellular metabolic process	biological_process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
EOG8N8TKW	GO:0005975	11/82	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8N8TKW	GO:0004553	10/82	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8N8TKW	GO:0004563	1/82	beta-N-acetylhexosaminidase activity	molecular_function	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]
EOG8616K8	GO:0016021	29/137	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8616K8	GO:0055085	28/137	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8616K8	GO:0015293	1/137	symporter activity	molecular_function	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
EOG8616K8	GO:0006816	1/137	calcium ion transport	biological_process	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8616K8	GO:0008273	1/137	calcium, potassium:sodium antiporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1]
EOG8616K8	GO:0035725	1/137	sodium ion transmembrane transport	biological_process	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
EOG8616K8	GO:0006814	1/137	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8616K8	GO:0048749	1/137	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8616K8	GO:0048812	1/137	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8616K3	GO:0005737	26/108	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8616K3	GO:0016149	26/108	translation release factor activity, codon specific	molecular_function	"A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684]
EOG8616K3	GO:0003747	1/108	translation release factor activity	molecular_function	"Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]
EOG8M3CPK	GO:0003678	9/67	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8M3CPK	GO:0000723	9/67	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8M3CPK	GO:0006281	9/67	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8M3CPK	GO:0004386	3/67	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8M3CPK	GO:0005524	3/67	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8M3CPK	GO:0003676	1/67	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M3CPK	GO:0006511	1/67	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8XKXMX	GO:0046872	22/110	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XKXMX	GO:0016491	17/110	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8XKXMX	GO:0005739	4/110	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8XKXMX	GO:0047988	4/110	hydroxyacid-oxoacid transhydrogenase activity	molecular_function	"Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate." [EC:1.1.99.24, MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN]
EOG8XKXMX	GO:0015993	4/110	molecular hydrogen transport	biological_process	"The directed movement of molecular hydrogen (H2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
EOG8XKXMX	GO:0050093	1/110	methanol dehydrogenase activity	molecular_function	"Catalysis of the reaction: methanol + NAD(+) = formaldehyde + H(+) + NADH." [EC:1.1.1.244, RHEA:19404]
EOG81RS7S	GO:0005524	51/178	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG81RS7S	GO:0016021	47/178	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81RS7S	GO:0004672	47/178	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG81RS7S	GO:0035556	46/178	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG81RS7S	GO:0004383	42/178	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG81RS7S	GO:0016849	4/178	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG81RS7S	GO:0009190	4/178	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG81RS7S	GO:0016772	2/178	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG81RS7S	GO:0004709	1/178	MAP kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
EOG81RS7S	GO:0004715	1/178	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG81RS7Z	GO:0016740	46/887	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG81RS7Z	GO:0004364	41/887	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG81RS7Z	GO:0006749	24/887	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG81RS7Z	GO:0018833	4/887	DDT-dehydrochlorinase activity	molecular_function	"Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)." [EC:4.5.1.1, RHEA:19220]
EOG81RS7Z	GO:0005515	2/887	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG81RS7Z	GO:0005576	2/887	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG81RS7Z	GO:0004602	2/887	glutathione peroxidase activity	molecular_function	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9]
EOG81RS7Z	GO:0009408	1/887	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG81RS7Z	GO:0055114	1/887	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG81RS7Z	GO:0022008	1/887	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG81RS7Z	GO:0008152	1/887	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG81NX1M	GO:0008270	22/81	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81NX1M	GO:0009056	22/81	catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]
EOG81NX1M	GO:0016788	14/81	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG80GG6X	GO:0005615	2/61	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8WWTZS	GO:0030036	25/93	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8WWTZS	GO:0042273	25/93	ribosomal large subunit biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]
EOG8WWTZS	GO:0000055	25/93	ribosomal large subunit export from nucleus	biological_process	"The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah]
EOG8WWTZS	GO:0005730	1/93	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8WWTZS	GO:0046854	1/93	phosphatidylinositol phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]
EOG8WWTZS	GO:0015031	1/93	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8WWTZS	GO:0022008	1/93	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8DJN99	GO:0005524	1/16	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8DJN99	GO:0003824	1/16	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8DJN99	GO:0046872	1/16	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DJN99	GO:0006807	1/16	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG80GG6J	GO:0042048	1/84	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG80GG67	GO:0006950	2/58	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG80GG67	GO:0046872	1/58	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80GG67	GO:0020037	1/58	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG80GG63	GO:0005254	42/136	chloride channel activity	molecular_function	"Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG80GG63	GO:0034707	42/136	chloride channel complex	cellular_component	"An ion channel complex through which chloride ions pass." [GOC:mah]
EOG80GG63	GO:1902476	2/136	chloride transmembrane transport	biological_process	"The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw]
EOG80GG63	GO:0005886	2/136	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80GG63	GO:0016319	1/136	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG80GG63	GO:0016021	1/136	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80GG63	GO:0006909	1/136	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG80GG63	GO:0002121	1/136	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8DJN9D	GO:0004176	33/104	ATP-dependent peptidase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah]
EOG8DJN9D	GO:0005524	33/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8DJN9D	GO:0004252	33/104	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8DJN9D	GO:0006515	27/104	misfolded or incompletely synthesized protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]
EOG8DJN9D	GO:0090296	24/104	regulation of mitochondrial DNA replication	biological_process	"Any process that modulates the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb]
EOG8DJN9D	GO:0070407	24/104	oxidation-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein." [GOC:mah]
EOG8DJN9D	GO:0005759	24/104	mitochondrial matrix	cellular_component	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]
EOG8DJN9D	GO:0051131	24/104	chaperone-mediated protein complex assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai]
EOG8DJN9D	GO:0043565	24/104	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8DJN9D	GO:0034599	24/104	cellular response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
EOG8DJN9D	GO:0030163	6/104	protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]
EOG8DJN9D	GO:0005739	1/104	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8DJN9D	GO:0007005	1/104	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8QNQBP	GO:0005581	1/64	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8R267T	GO:0003676	3/40	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8R267T	GO:0008270	2/40	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8R267T	GO:0005634	2/40	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8R267T	GO:0046872	1/40	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QNQBH	GO:0006284	27/87	base-excision repair	biological_process	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]
EOG8QNQBH	GO:0003677	27/87	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8QNQBH	GO:0051539	26/87	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8QNQBH	GO:0003824	18/87	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8QNQBH	GO:0003906	7/87	DNA-(apurinic or apyrimidinic site) lyase activity	molecular_function	"Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18]
EOG8QNQBH	GO:0004519	2/87	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8QNQBH	GO:0006974	1/87	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8Q5C3R	GO:0016021	6/41	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Q5C3R	GO:0006810	6/41	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8Q5C3T	GO:0005524	27/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8Q5C3T	GO:0006420	26/91	arginyl-tRNA aminoacylation	biological_process	"The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8Q5C3T	GO:0004814	26/91	arginine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19]
EOG8Q5C3T	GO:0006418	1/91	tRNA aminoacylation for protein translation	biological_process	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]
EOG8Q5C3T	GO:0004812	1/91	aminoacyl-tRNA ligase activity	molecular_function	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
EOG8R267Z	GO:0004725	5/42	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8R267Z	GO:0008138	5/42	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG8R267Z	GO:0007165	2/42	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8R267Z	GO:0016491	1/42	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8R267Z	GO:0005622	1/42	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8616KS	GO:0030170	25/130	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8616KS	GO:0003824	25/130	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8616KS	GO:0030151	25/130	molybdenum ion binding	molecular_function	"Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai]
EOG83N9VJ	GO:0030150	25/83	protein import into mitochondrial matrix	biological_process	"The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]
EOG83N9VJ	GO:0005744	25/83	mitochondrial inner membrane presequence translocase complex	cellular_component	"The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659]
EOG83N9VJ	GO:0008566	2/83	mitochondrial protein-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex." [EC:3.6.3.51]
EOG8KD921	GO:0016021	48/108	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KD921	GO:0030054	47/108	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8KD921	GO:0045202	47/108	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8KD921	GO:0005230	47/108	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8KD921	GO:0005886	47/108	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8KD921	GO:0006811	2/108	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8KD921	GO:0006909	1/108	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8KD921	GO:0016020	1/108	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG84BDHV	GO:0016021	2/31	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NGK38	GO:0003676	1/15	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NGK38	GO:0004672	1/15	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8NGK38	GO:0005524	1/15	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82VBX0	GO:0000166	26/74	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG82VBX0	GO:0003676	26/74	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG808QPN	GO:0005524	15/77	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG808QPN	GO:0006298	15/77	mismatch repair	biological_process	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
EOG808QPN	GO:0030983	15/77	mismatched DNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]
EOG8TTK15	GO:0003677	28/194	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TTK15	GO:0004518	28/194	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8TTK15	GO:0005634	7/194	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TTK15	GO:0016568	7/194	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG82VBX6	GO:0003735	26/94	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG82VBX6	GO:0005840	26/94	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG82VBX6	GO:0006412	26/94	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG82VBX6	GO:0003723	23/94	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG82VBX6	GO:0019843	2/94	rRNA binding	molecular_function	"Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl]
EOG82VBX6	GO:0051298	1/94	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG82VBX6	GO:0051297	1/94	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG82VBX6	GO:0000022	1/94	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG82VBX6	GO:0007052	1/94	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG86Q99B	GO:0005576	3/19	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8D55DV	GO:0003743	29/83	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8D55DV	GO:0006417	2/83	regulation of translation	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8D55DV	GO:0071456	1/83	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG81RS9W	GO:0003700	3/37	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG81RS9W	GO:0003677	3/37	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG82JR5H	GO:0016020	86/342	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82JR5H	GO:0008236	85/342	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG82JR5H	GO:0006508	7/342	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG82JR5H	GO:0008239	2/342	dipeptidyl-peptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]
EOG82JR5H	GO:0016491	1/342	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG82JR5H	GO:0005576	1/342	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG808QPW	GO:0003677	4/11	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG808QPW	GO:0005634	4/11	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8M3CQZ	GO:0018024	2/29	histone-lysine N-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]
EOG8M3CQZ	GO:0000062	1/29	fatty-acyl-CoA binding	molecular_function	"Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732]
EOG81RS9B	GO:0016787	10/56	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8BVV8X	GO:0003950	1/78	NAD+ ADP-ribosyltransferase activity	molecular_function	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]
EOG8BVV8X	GO:0016798	1/78	hydrolase activity, acting on glycosyl bonds	molecular_function	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]
EOG808QPQ	GO:0005634	25/87	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG808QPQ	GO:0007549	2/87	dosage compensation	biological_process	"Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes." [GOC:ems, ISBN:0140512888, PMID:11498577]
EOG808QPQ	GO:0003682	2/87	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG808QPQ	GO:0006351	2/87	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG808QPQ	GO:0000805	2/87	X chromosome	cellular_component	"The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, ISBN:0582227089]
EOG808QPQ	GO:0016568	2/87	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG808QPQ	GO:0035206	1/87	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG808QPQ	GO:0009047	1/87	dosage compensation by hyperactivation of X chromosome	biological_process	"Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577]
EOG808QPQ	GO:0016456	1/87	X chromosome located dosage compensation complex, transcription activating	cellular_component	"An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster." [GOC:ma, GOC:mtg_sensu]
EOG808QPQ	GO:0003729	1/87	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG808QPQ	GO:0035064	1/87	methylated histone binding	molecular_function	"Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf, PMID:14585615]
EOG808QPQ	GO:0031936	1/87	negative regulation of chromatin silencing	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah]
EOG808QPQ	GO:0006355	1/87	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8HTC7D	GO:0003723	26/76	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8HTC7D	GO:0000178	25/76	exosome (RNase complex)	cellular_component	"Complex of 3'-5' exoribonucleases." [PMID:10465791]
EOG8HTC7D	GO:0004527	5/76	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8HTC7D	GO:0005652	1/76	nuclear lamina	cellular_component	"The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363]
EOG8HTC7D	GO:0000176	1/76	nuclear exosome (RNase complex)	cellular_component	"Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]
EOG8HTC7D	GO:0010468	1/76	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8HTC7D	GO:0005737	1/76	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HTC7G	GO:0016021	29/90	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HTC7G	GO:0043066	14/90	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8HTC7G	GO:0006915	1/90	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8HTC7G	GO:0009267	1/90	cellular response to starvation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]
EOG8HTC7G	GO:0005789	1/90	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8HTC7G	GO:0035071	1/90	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8HTC7G	GO:0060702	1/90	negative regulation of endoribonuclease activity	biological_process	"Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb]
EOG8HTC7G	GO:0060548	1/90	negative regulation of cell death	biological_process	"Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]
EOG8HTC7G	GO:0010507	1/90	negative regulation of autophagy	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8HTC7G	GO:0006986	1/90	response to unfolded protein	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl]
EOG8HTC7T	GO:0006275	26/107	regulation of DNA replication	biological_process	"Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]
EOG8HTC7T	GO:0007348	1/107	regulation of syncytial blastoderm mitotic cell cycle	biological_process	"A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8HTC7T	GO:0007307	1/107	eggshell chorion gene amplification	biological_process	"Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771]
EOG8HTC7T	GO:0007113	1/107	endomitotic cell cycle	biological_process	"A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm]
EOG8HTC7T	GO:0005634	1/107	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HTC7T	GO:0042059	1/107	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8HTC7T	GO:0008156	1/107	negative regulation of DNA replication	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators]
EOG8BK7MJ	GO:0005852	26/88	eukaryotic translation initiation factor 3 complex	cellular_component	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]
EOG8BK7MJ	GO:0003743	26/88	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8BK7MJ	GO:0006446	22/88	regulation of translational initiation	biological_process	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG8BK7MJ	GO:0001731	22/88	formation of translation preinitiation complex	biological_process	"The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd]
EOG8BK7MJ	GO:0016282	22/88	eukaryotic 43S preinitiation complex	cellular_component	"A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049]
EOG8BK7MJ	GO:0033290	22/88	eukaryotic 48S preinitiation complex	cellular_component	"A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049]
EOG8BK7MJ	GO:0022008	1/88	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8BK7MJ	GO:0006413	1/88	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG8BK7MJ	GO:0005515	1/88	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG86HJT3	GO:0045454	38/103	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG86HJT3	GO:0009055	38/103	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG86HJT3	GO:0015035	38/103	protein disulfide oxidoreductase activity	molecular_function	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]
EOG86HJT3	GO:0022008	1/103	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8HTC77	GO:0003676	1/99	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KH58R	GO:0004725	18/82	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8KH58R	GO:0050254	2/82	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8KH58R	GO:0005777	1/82	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8DV81C	GO:0016740	2/140	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8D55D8	GO:0005509	33/145	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8D55D8	GO:0007229	4/145	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG8D55D8	GO:0016301	2/145	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8D55D8	GO:0004721	1/145	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8D55D8	GO:0055074	1/145	calcium ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]
EOG8D55D8	GO:0007602	1/145	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG8RFP88	GO:0003700	20/70	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8RFP88	GO:0043565	20/70	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8RFP88	GO:0005634	19/70	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RFP88	GO:0006351	19/70	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8RFP88	GO:0007389	1/70	pattern specification process	biological_process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
EOG8RFP88	GO:0009888	1/70	tissue development	biological_process	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]
EOG8RFP88	GO:0008301	1/70	DNA binding, bending	molecular_function	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]
EOG8RZ1G2	GO:0016021	1/87	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8642S4	GO:0003824	64/235	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8642S4	GO:0047747	4/235	cholate-CoA ligase activity	molecular_function	"Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA." [EC:6.2.1.7, MetaCyc:CHOLATE--COA-LIGASE-RXN]
EOG8642S4	GO:0016874	1/235	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8642S4	GO:0005886	1/235	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8642S4	GO:0015909	1/235	long-chain fatty acid transport	biological_process	"The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ai]
EOG8642S4	GO:0070328	1/235	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG8642S4	GO:0005324	1/235	long-chain fatty acid transporter activity	molecular_function	"Enables the directed movement of long-chain fatty acids into, out of or within a cell, or between cells. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, ISBN:0198506732]
EOG82VBXB	GO:0005549	1/102	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8BVV87	GO:0004842	25/91	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8BVV87	GO:0008270	25/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V9X72	GO:0008270	41/538	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V9X72	GO:0003676	38/538	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V9X72	GO:0003964	3/538	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8V9X72	GO:0003723	3/538	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8V9X72	GO:0006811	1/538	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8V9X72	GO:0005921	1/538	gap junction	cellular_component	"A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181]
EOG8S1WQ0	GO:0046872	4/35	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8S1WQ7	GO:0003676	1/20	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8S1WQ7	GO:0015074	1/20	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8S1WQ5	GO:0003723	27/94	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8S1WQ5	GO:0005634	27/94	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8S1WQ5	GO:0005737	27/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8S1WQ5	GO:0006397	26/94	mRNA processing	biological_process	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]
EOG8S1WQ5	GO:0071254	1/94	cytoplasmic U snRNP body	cellular_component	"A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295]
EOG8S1WQ5	GO:0017145	1/94	stem cell division	biological_process	"The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089]
EOG8S1WQ5	GO:0031674	1/94	I band	cellular_component	"A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131]
EOG8S1WQ5	GO:0000387	1/94	spliceosomal snRNP assembly	biological_process	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8S1WQ5	GO:0051276	1/94	chromosome organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8S1WQ5	GO:0031594	1/94	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8S1WQ5	GO:0097113	1/94	AMPA glutamate receptor clustering	biological_process	"The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane." [GOC:BHF, GOC:pr, GOC:sjp, PMID:12796785]
EOG8S1WQ5	GO:0030240	1/94	skeletal muscle thin filament assembly	biological_process	"The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle]
EOG8S1WQ5	GO:0007274	1/94	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8S1WQ5	GO:0060079	1/94	excitatory postsynaptic potential	biological_process	"A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dph, GOC:ef]
EOG8S1WQ5	GO:0007528	1/94	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8S1WQ5	GO:0035154	1/94	terminal cell fate specification, open tracheal system	biological_process	"The process in which a cell in an open tracheal system becomes capable of differentiating autonomously into a terminal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Terminal cells send long and bifurcated hollow branches toward target tissues to allow oxygen exchange." [GOC:mtg_sensu, PMID:10684581, PMID:11063940]
EOG8S1WQ5	GO:0009790	1/94	embryo development	biological_process	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
EOG8S1WQ5	GO:0048601	1/94	oocyte morphogenesis	biological_process	"The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators]
EOG8S1WQ5	GO:0051393	1/94	alpha-actinin binding	molecular_function	"Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats." [PMID:10984498, PMID:11699871, PMID:15014165]
EOG8S1WQ5	GO:0048863	1/94	stem cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]
EOG8S1WQ5	GO:0005681	1/94	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8S1WQ5	GO:0000398	1/94	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8S1WQ5	GO:0045175	1/94	basal protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf]
EOG8S1WQ5	GO:1990194	1/94	cytoplasmic U snRNP body assembly	biological_process	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic U snRNP body." [PMID:19464282]
EOG8S1WQ5	GO:0072089	1/94	stem cell proliferation	biological_process	"The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
EOG8S1WQ5	GO:0033962	1/94	cytoplasmic mRNA processing body assembly	biological_process	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074]
EOG8S1WQ5	GO:0034718	1/94	SMN-Gemin2 complex	cellular_component	"A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex." [GOC:mah, PMID:17640873]
EOG8S1WQ5	GO:0005515	1/94	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8S1WQ5	GO:0022618	1/94	ribonucleoprotein complex assembly	biological_process	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]
EOG8S1WQ5	GO:0034730	1/94	SmD-containing SMN-Sm protein complex	cellular_component	"An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex." [PMID:12975319, PMID:17401408]
EOG8S1WQ5	GO:0042802	1/94	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG8S1WQ5	GO:0008345	1/94	larval locomotory behavior	biological_process	"Locomotory behavior in a larval (immature) organism." [GOC:ai]
EOG8S1WQ5	GO:0015030	1/94	Cajal body	cellular_component	"A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]
EOG8S1WQ5	GO:0097504	1/94	Gemini of coiled bodies	cellular_component	"Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA)." [GOC:pr, http://en.wikipedia.org/wiki/Cell_nucleus#Cajal_bodies_and_gems, PMID:11031238, PMID:9683623]
EOG8S1WQ5	GO:0072553	1/94	terminal button organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:BHF, GOC:mah]
EOG8S1WQ5	GO:0030018	1/94	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8S1WQ5	GO:0002164	1/94	larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088]
EOG8S1WQ5	GO:0007417	1/94	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8S1WQ5	GO:0032224	1/94	positive regulation of synaptic transmission, cholinergic	biological_process	"Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
EOG8DJNBT	GO:0051017	1/89	actin filament bundle assembly	biological_process	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
EOG8DJNBT	GO:0030715	1/89	oocyte growth in germarium-derived egg chamber	biological_process	"The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8DJNBT	GO:0008407	1/89	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG8DJNBT	GO:0046843	1/89	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8DJNBT	GO:0015630	1/89	microtubule cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]
EOG8DJNBT	GO:0006403	1/89	RNA localization	biological_process	"A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai]
EOG8DJNBT	GO:0051663	1/89	oocyte nucleus localization involved in oocyte dorsal/ventral axis specification	biological_process	"The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte." [GOC:ai, GOC:dph, GOC:mtg_sensu, GOC:tb]
EOG8DJNBT	GO:0030720	1/89	oocyte localization involved in germarium-derived egg chamber formation	biological_process	"Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356]
EOG8DJNBT	GO:0016325	1/89	oocyte microtubule cytoskeleton organization	biological_process	"Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]
EOG8DJNBV	GO:0055114	4/35	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8DJNBQ	GO:0045944	6/44	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8DJNBQ	GO:0016607	6/44	nuclear speck	cellular_component	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]
EOG8DJNBQ	GO:0003713	6/44	transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8DJNBQ	GO:0007219	6/44	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG896277	GO:0008138	26/87	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG896277	GO:0004725	25/87	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG896277	GO:0006470	2/87	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG896277	GO:0006655	1/87	phosphatidylglycerol biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [ISBN:0198506732]
EOG896277	GO:0005743	1/87	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG896277	GO:0004439	1/87	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36, RHEA:22767]
EOG896277	GO:0046855	1/87	inositol phosphate dephosphorylation	biological_process	"The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]
EOG896277	GO:0006200	1/87	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG896277	GO:0022008	1/87	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG896277	GO:0008962	1/87	phosphatidylglycerophosphatase activity	molecular_function	"Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate." [EC:3.1.3.27]
EOG82C0RV	GO:0006412	2/70	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG82C0RV	GO:0005762	2/70	mitochondrial large ribosomal subunit	cellular_component	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
EOG82C0RV	GO:0005840	2/70	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG82C0RV	GO:0003735	2/70	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8VHNN6	GO:0046496	25/94	nicotinamide nucleotide metabolic process	biological_process	"The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732]
EOG8VHNN6	GO:0005524	25/94	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VHNN6	GO:0047453	25/94	ATP-dependent NAD(P)H-hydrate dehydratase activity	molecular_function	"Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H(+) + NADH + phosphate." [EC:4.2.1.93, RHEA:19020]
EOG84N16G	GO:0005328	263/840	neurotransmitter:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
EOG84N16G	GO:0016021	251/840	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84N16G	GO:0003333	12/840	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG84N16G	GO:0005887	12/840	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84N16G	GO:0042940	11/840	D-amino acid transport	biological_process	"The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
EOG84N16G	GO:0042943	11/840	D-amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
EOG84N16G	GO:0005283	11/840	sodium:amino acid symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai]
EOG84N16G	GO:0015804	11/840	neutral amino acid transport	biological_process	"The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84N16G	GO:0015175	11/840	neutral amino acid transmembrane transporter activity	molecular_function	"Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG84N16G	GO:0006814	11/840	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84N16G	GO:0005326	7/840	neurotransmitter transporter activity	molecular_function	"Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732]
EOG84N16G	GO:0006836	7/840	neurotransmitter transport	biological_process	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]
EOG84N16G	GO:0005886	2/840	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG84N16G	GO:0019811	1/840	cocaine binding	molecular_function	"Interacting selectively and non-covalently with cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis." [GOC:jl, ISBN:0198506732]
EOG84N16G	GO:0015872	1/840	dopamine transport	biological_process	"The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
EOG84N16G	GO:0015222	1/840	serotonin transmembrane transporter activity	molecular_function	"Enables the transfer of serotonin from one side of the membrane to the other. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
EOG84N16G	GO:0004181	1/840	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG84N16G	GO:0015179	1/840	L-amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
EOG84N16G	GO:0030431	1/840	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG84N16G	GO:0042745	1/840	circadian sleep/wake cycle	biological_process	"The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com]
EOG84N16G	GO:0043679	1/840	axon terminus	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl]
EOG84N16G	GO:0015807	1/840	L-amino acid transport	biological_process	"The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah]
EOG84N16G	GO:0006909	1/840	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG84N16G	GO:0010226	1/840	response to lithium ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:tb]
EOG84N16G	GO:1902475	1/840	L-alpha-amino acid transmembrane transport	biological_process	"The directed movement of L-alpha-amino acid across a membrane." [GOC:kmv, GOC:TermGenie, PMID:14668347]
EOG84N16G	GO:0005416	1/840	cation:amino acid symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai]
EOG84N16G	GO:0046872	1/840	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84N16G	GO:0005261	1/840	cation channel activity	molecular_function	"Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG84N16G	GO:0030424	1/840	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG84N16G	GO:0008270	1/840	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84N16G	GO:0015844	1/840	monoamine transport	biological_process	"The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:25375, GOC:mah]
EOG84N16G	GO:0051610	1/840	serotonin uptake	biological_process	"The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
EOG84N16G	GO:0006837	1/840	serotonin transport	biological_process	"The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
EOG84N16G	GO:0008504	1/840	monoamine transmembrane transporter activity	molecular_function	"Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other." [CHEBI:25375, GOC:mah]
EOG84N16G	GO:0005329	1/840	dopamine transmembrane transporter activity	molecular_function	"Enables the transfer of dopamine from one side of the membrane to the other. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
EOG84N16G	GO:0007632	1/840	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG82C0RB	GO:0003676	26/100	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82C0RB	GO:0004527	25/100	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG84N16D	GO:0016021	26/116	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84N16D	GO:0001607	18/116	neuromedin U receptor activity	molecular_function	"Combining with neuromedin U to initiate a change in cell activity." [GOC:ai]
EOG84N16D	GO:0004930	8/116	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG84N16D	GO:0007218	2/116	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG84N16D	GO:0007589	1/116	body fluid secretion	biological_process	"The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb]
EOG84N16D	GO:0071465	1/116	cellular response to desiccation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:mah]
EOG84N16D	GO:0050254	1/116	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG84N16D	GO:0016323	1/116	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG84N16D	GO:0003723	1/116	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG84N16D	GO:0008188	1/116	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG84N16D	GO:0007186	1/116	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG84N16D	GO:0051928	1/116	positive regulation of calcium ion transport	biological_process	"Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84N16D	GO:0003964	1/116	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8SN44K	GO:0005700	1/82	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8SN44K	GO:0005737	1/82	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SN44K	GO:0048812	1/82	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8SN44K	GO:0005634	1/82	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RBT14	GO:0005737	2/106	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RBT14	GO:0046843	2/106	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8RBT14	GO:0006967	1/106	positive regulation of antifungal peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah]
EOG8RBT14	GO:0009620	1/106	response to fungus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
EOG8RBT14	GO:0008063	1/106	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8RBT14	GO:0007275	1/106	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8RBT14	GO:0006974	1/106	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8RBT14	GO:0019730	1/106	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG8RBT14	GO:0019732	1/106	antifungal humoral response	biological_process	"An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8RBT14	GO:0006909	1/106	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8RBT14	GO:0008134	1/106	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8RBT14	GO:0005515	1/106	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8RBT14	GO:0009950	1/106	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8RBT14	GO:0006955	1/106	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8RBT14	GO:0007399	1/106	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8RBT14	GO:0031594	1/106	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8RBT14	GO:0045087	1/106	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8RBT14	GO:0048477	1/106	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8RBT14	GO:0006952	1/106	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8RBT14	GO:0042994	1/106	cytoplasmic sequestering of transcription factor	biological_process	"The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl]
EOG8RBT14	GO:0030097	1/106	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG8RBT14	GO:0004623	1/106	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG89627W	GO:0008033	5/68	tRNA processing	biological_process	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]
EOG89627W	GO:0005524	5/68	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG89627W	GO:0016740	1/68	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG82C0R0	GO:0016020	30/92	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RBT1M	GO:0005634	84/201	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RBT1M	GO:0006351	83/201	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8RBT1M	GO:0003677	79/201	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RBT1M	GO:0006355	79/201	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8RBT1M	GO:0003700	5/201	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8RBT1M	GO:0048749	5/201	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8RBT1M	GO:0043565	5/201	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8RBT1M	GO:0007219	4/201	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8RBT1M	GO:0000122	4/201	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8RBT1M	GO:0005515	2/201	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8RBT1M	GO:0008134	2/201	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8RBT1M	GO:0030154	2/201	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8RBT1M	GO:0007399	2/201	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8RBT1M	GO:0048666	1/201	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8RBT1M	GO:0002052	1/201	positive regulation of neuroblast proliferation	biological_process	"Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph]
EOG8RBT1M	GO:2001020	1/201	regulation of response to DNA damage stimulus	biological_process	"Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
EOG8RBT1M	GO:0001964	1/201	startle response	biological_process	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
EOG8RBT1M	GO:0048190	1/201	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8RBT1M	GO:0045466	1/201	R7 cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339]
EOG8RBT1M	GO:0001078	1/201	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
EOG8RBT1M	GO:0048813	1/201	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8RBT1M	GO:0048052	1/201	R1/R6 cell differentiation	biological_process	"The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid]
EOG8RBT1M	GO:0031987	1/201	locomotion involved in locomotory behavior	biological_process	"Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
EOG8RBT1M	GO:0048854	1/201	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG84N169	GO:0005524	27/90	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG84N169	GO:0006457	27/90	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG84N169	GO:0005737	26/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84N169	GO:0000285	1/90	1-phosphatidylinositol-3-phosphate 5-kinase activity	molecular_function	"Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13612]
EOG84N169	GO:0042623	1/90	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG84N169	GO:0060439	1/90	trachea morphogenesis	biological_process	"The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG84N169	GO:0005832	1/90	chaperonin-containing T-complex	cellular_component	"A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267]
EOG84N169	GO:0007430	1/90	terminal branching, open tracheal system	biological_process	"Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG84N169	GO:0006200	1/90	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG84N169	GO:0007052	1/90	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG84N169	GO:0005875	1/90	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG89627C	GO:0022008	1/85	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG89627C	GO:0000022	1/85	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8JHFW3	GO:0016491	83/244	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8JHFW3	GO:0046592	2/244	polyamine oxidase activity	molecular_function	"Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380]
EOG8JHFW3	GO:0046872	1/244	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8JHFW3	GO:0050232	1/244	putrescine oxidase activity	molecular_function	"Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2." [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN]
EOG8JHFW3	GO:0005615	1/244	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8JHFW3	GO:0003676	1/244	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JHFW1	GO:0046872	18/79	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8JHFW1	GO:0003796	1/79	lysozyme activity	molecular_function	"Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17]
EOG8JHFW1	GO:0010629	1/79	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8JHFW1	GO:0042826	1/79	histone deacetylase binding	molecular_function	"Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl]
EOG8JHFW1	GO:0016706	1/79	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG8JHFW1	GO:0031418	1/79	L-ascorbic acid binding	molecular_function	"Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]
EOG8JHFW1	GO:0005506	1/79	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8JHFW1	GO:0005737	1/79	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG88GZHW	GO:0046872	20/86	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG88GZHW	GO:0005634	3/86	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88GZHW	GO:0003676	2/86	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88GZHW	GO:0008017	1/86	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG88GZHW	GO:0035191	1/86	nuclear axial expansion	biological_process	"The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex." [PMID:8314839]
EOG88GZHW	GO:0005813	1/86	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG88GZHW	GO:0006355	1/86	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG88GZHW	GO:0005704	1/86	polytene chromosome band	cellular_component	"A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342]
EOG88GZHW	GO:0003682	1/86	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG88GZHW	GO:0005515	1/86	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG88GZHW	GO:0005875	1/86	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG88GZHW	GO:0031208	1/86	POZ domain binding	molecular_function	"Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847]
EOG88GZHW	GO:0005874	1/86	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG88GZHW	GO:0090202	1/86	gene looping	biological_process	"The formation and maintenance of DNA loops that juxtapose sequentially separated regions of RNA polymerase II-transcribed genes." [GOC:dph, GOC:rb, GOC:tb, PMID:19923429, PMID:19933150]
EOG88GZHW	GO:0016568	1/86	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG88GZHW	GO:0005737	1/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG88GZHW	GO:0007017	1/86	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG88GZHW	GO:0005700	1/86	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG88GZHW	GO:0006351	1/86	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG88GZHW	GO:0051493	1/86	regulation of cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
EOG88GZHW	GO:0043035	1/86	chromatin insulator sequence binding	molecular_function	"Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795]
EOG88GZHW	GO:0003677	1/86	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8ZW7SH	GO:0008270	1/86	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG88GZHM	GO:0003676	8/57	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88GZHM	GO:0005524	1/57	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88GZHM	GO:0004386	1/57	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG88GZHJ	GO:0046872	26/118	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG88GZHJ	GO:0003676	26/118	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG800400	GO:0046331	2/92	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG800400	GO:0006816	2/92	calcium ion transport	biological_process	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG800400	GO:0005262	2/92	calcium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG800400	GO:0005764	2/92	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG800400	GO:0044130	2/92	negative regulation of growth of symbiont in host	biological_process	"Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
EOG800400	GO:0006914	2/92	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG800400	GO:0006874	2/92	cellular calcium ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah]
EOG800400	GO:0032008	2/92	positive regulation of TOR signaling	biological_process	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG800400	GO:0070588	2/92	calcium ion transmembrane transport	biological_process	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG800400	GO:0005765	2/92	lysosomal membrane	cellular_component	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]
EOG800400	GO:0000046	2/92	autophagosome maturation	biological_process	"The process in which autophagosomes, double-membraned vacuoles containing cytoplasmic material fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [GOC:autophagy, GOC:lf, PMID:11099404, PMID:16874026, PMID:17534139]
EOG800400	GO:0031902	2/92	late endosome membrane	cellular_component	"The lipid bilayer surrounding a late endosome." [GOC:pz]
EOG8KSRZV	GO:0000502	4/102	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG8KSRZV	GO:0009987	1/102	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8KSRZV	GO:0006508	1/102	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8KSRZV	GO:0005838	1/102	proteasome regulatory particle	cellular_component	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]
EOG8KSRZV	GO:0008541	1/102	proteasome regulatory particle, lid subcomplex	cellular_component	"The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb]
EOG8KSRZV	GO:0022008	1/102	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8KSRZV	GO:0043161	1/102	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG85B3X1	GO:0006355	25/86	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85B3X1	GO:0005634	25/86	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85B3X1	GO:0003743	2/86	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG85B3X1	GO:0043486	1/86	histone exchange	biological_process	"The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]
EOG85B3X1	GO:0035267	1/86	NuA4 histone acetyltransferase complex	cellular_component	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]
EOG85B3X1	GO:0000123	1/86	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG85B3X1	GO:0016573	1/86	histone acetylation	biological_process	"The modification of a histone by the addition of an acetyl group." [GOC:ai]
EOG85B3X1	GO:0006367	1/86	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG85B3X1	GO:0005669	1/86	transcription factor TFIID complex	cellular_component	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]
EOG8C5G2F	GO:0000276	3/75	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	cellular_component	"All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056]
EOG8C5G2F	GO:0015986	3/75	ATP synthesis coupled proton transport	biological_process	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]
EOG8C5G2F	GO:0015078	3/75	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG8C5G2F	GO:0046872	2/75	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8C5G2F	GO:0008270	1/75	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8C5G2F	GO:0003676	1/75	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85MQNQ	GO:0005737	27/98	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG85MQNQ	GO:0016021	1/98	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85MQNQ	GO:0008360	1/98	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG85MQNP	GO:0032981	25/83	mitochondrial respiratory chain complex I assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]
EOG837TWH	GO:0006633	21/66	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG837TWH	GO:0070469	1/66	respiratory chain	cellular_component	"The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684]
EOG837TWH	GO:0031177	1/66	phosphopantetheine binding	molecular_function	"Interacting selectively and non-covalently with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah, GOC:vw]
EOG837TWH	GO:0005739	1/66	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG837TWH	GO:0006120	1/66	mitochondrial electron transport, NADH to ubiquinone	biological_process	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363]
EOG837TWH	GO:0000036	1/66	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process	molecular_function	"Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis." [CHEBI:22221, GOC:jl, GOC:vw]
EOG8THZ77	GO:0006633	5/92	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG837TWN	GO:0005737	1/84	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG837TWN	GO:0043281	1/84	regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis." [GOC:jl, GOC:mtg_apoptosis]
EOG8THZ7H	GO:0005524	51/170	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8THZ7H	GO:0005737	49/170	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8THZ7H	GO:0017111	47/170	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8THZ7H	GO:0030163	47/170	protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]
EOG8THZ7H	GO:0008233	8/170	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8THZ7H	GO:0008568	3/170	microtubule-severing ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766]
EOG8THZ7H	GO:0008540	2/170	proteasome regulatory particle, base subcomplex	cellular_component	"The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb]
EOG8THZ7H	GO:0005838	2/170	proteasome regulatory particle	cellular_component	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]
EOG8THZ7H	GO:0006508	2/170	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8THZ7H	GO:0043161	2/170	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG8THZ7H	GO:0006974	2/170	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8THZ7H	GO:0005634	1/170	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8THZ7H	GO:0001673	1/170	male germ cell nucleus	cellular_component	"The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu]
EOG8THZ7H	GO:0042026	1/170	protein refolding	biological_process	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]
EOG8THZ7H	GO:0000022	1/170	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8THZ7H	GO:0007052	1/170	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8THZ7H	GO:0008283	1/170	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8THZ7H	GO:0000502	1/170	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG8THZ7H	GO:0009987	1/170	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG81NX2C	GO:0016021	25/89	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81NX2C	GO:0004671	25/89	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester." [EC:2.1.1.100]
EOG81NX2C	GO:0005783	24/89	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG85MQN9	GO:0004252	1/10	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG85MQN9	GO:0016021	1/10	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GB9P4	GO:0006334	304/573	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8GB9P4	GO:0000786	304/573	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8GB9P4	GO:0003677	304/573	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GB9P4	GO:0005634	303/573	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GB9P4	GO:0005515	23/573	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8GB9P4	GO:0008360	2/573	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8GB9P4	GO:0007140	2/573	male meiosis	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
EOG8GB9P4	GO:0005700	2/573	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8GB9P4	GO:0007155	2/573	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8GB9P4	GO:0003747	1/573	translation release factor activity	molecular_function	"Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]
EOG8X0Q8F	GO:0016459	3/36	myosin complex	cellular_component	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
EOG8X0Q8F	GO:0005524	3/36	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X0Q8F	GO:0003774	3/36	motor activity	molecular_function	"Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
EOG8S4RX5	GO:0004252	53/134	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8S4RX5	GO:0005576	2/134	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8S4RX5	GO:0003824	1/134	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8S4RX5	GO:0006508	1/134	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG822D2Q	GO:0016192	1/81	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG822D2Q	GO:0005484	1/81	SNAP receptor activity	molecular_function	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
EOG822D2Q	GO:0022008	1/81	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8CNT65	GO:0030246	46/162	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG851H67	GO:0007264	25/81	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG851H67	GO:0005525	25/81	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG851H67	GO:0005622	24/81	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG851H67	GO:0048149	1/81	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG851H67	GO:0007269	1/81	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG851H67	GO:0005769	1/81	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG851H67	GO:0005794	1/81	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG851H67	GO:0005829	1/81	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG851H67	GO:0015031	1/81	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG851H67	GO:0003956	1/81	NAD(P)+-protein-arginine ADP-ribosyltransferase activity	molecular_function	"Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [EC:2.4.2.31]
EOG851H67	GO:0007283	1/81	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG851H67	GO:0030036	1/81	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG851H67	GO:0016197	1/81	endosomal transport	biological_process	"The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]
EOG851H67	GO:0007112	1/81	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG851H67	GO:0048488	1/81	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG851H67	GO:0006184	1/81	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG851H67	GO:0005886	1/81	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG851H67	GO:0007520	1/81	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG851H67	GO:0006471	1/81	protein ADP-ribosylation	biological_process	"The transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:pr, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295]
EOG851H67	GO:0055037	1/81	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG851H67	GO:0003924	1/81	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG834ZMJ	GO:0005737	16/81	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG834ZMJ	GO:0005524	16/81	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG834ZMJ	GO:0005856	15/81	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG834ZMJ	GO:0007010	1/81	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG834ZMJ	GO:0019896	1/81	axon transport of mitochondrion	biological_process	"The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai]
EOG834ZMJ	GO:0005884	1/81	actin filament	cellular_component	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]
EOG834ZMJ	GO:0008090	1/81	retrograde axon cargo transport	biological_process	"The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194]
EOG834ZMJ	GO:0005200	1/81	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG834ZMJ	GO:0005875	1/81	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG834ZMJ	GO:0007067	1/81	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG834ZMJ	GO:0008089	1/81	anterograde axon cargo transport	biological_process	"The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194]
EOG80S2X7	GO:0003677	4/29	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80S2X7	GO:0004518	4/29	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG80S2X7	GO:0008270	2/29	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8S1WNT	GO:0016021	13/53	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S1WNT	GO:0005230	7/53	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8S1WNT	GO:0030054	6/53	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8S1WNT	GO:0045211	6/53	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8S1WNT	GO:0004889	6/53	acetylcholine-activated cation-selective channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]
EOG8S1WND	GO:0030554	26/95	adenyl nucleotide binding	molecular_function	"Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732]
EOG8S1WND	GO:0006177	23/95	GMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732]
EOG8S1WND	GO:0003938	23/95	IMP dehydrogenase activity	molecular_function	"Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205]
EOG8S1WND	GO:0046872	23/95	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8S1WND	GO:0005737	21/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8S1WND	GO:0016491	2/95	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8S1WND	GO:0007411	1/95	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8S1WND	GO:0003824	1/95	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8S1WND	GO:0006909	1/95	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8S1WND	GO:0055114	1/95	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8S1WND	GO:0048477	1/95	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8K0T2M	GO:0003997	51/180	acyl-CoA oxidase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6]
EOG8K0T2M	GO:0005777	51/180	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8K0T2M	GO:0003995	51/180	acyl-CoA dehydrogenase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]
EOG8K0T2M	GO:0006635	48/180	fatty acid beta-oxidation	biological_process	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]
EOG8K0T2M	GO:0050660	48/180	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8K0T2M	GO:0006631	3/180	fatty acid metabolic process	biological_process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]
EOG8K0T2M	GO:0004970	1/180	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8K0T2M	GO:0005234	1/180	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8K0T2M	GO:0016020	1/180	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8K0T2M	GO:0006909	1/180	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8S1WNH	GO:0006890	2/89	retrograde vesicle-mediated transport, Golgi to ER	biological_process	"The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524]
EOG8S1WNH	GO:0005198	2/89	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8S1WNH	GO:0042384	1/89	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8VDSG8	GO:0003676	13/68	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VDSG8	GO:0008270	13/68	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RJJJ4	GO:0000381	1/51	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8FBM8G	GO:0046872	24/133	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8FBM8G	GO:0007476	1/133	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8FBM8G	GO:0009790	1/133	embryo development	biological_process	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
EOG8FBM8G	GO:0000381	1/133	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8FBM8G	GO:0003676	1/133	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FBM8G	GO:0003677	1/133	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FBM8G	GO:0001751	1/133	compound eye photoreceptor cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
EOG8FBM8G	GO:0007601	1/133	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8FBM8G	GO:0007525	1/133	somatic muscle development	biological_process	"The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
EOG8FBM8G	GO:0048471	1/133	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8FBM8G	GO:0046716	1/133	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG8FBM8G	GO:0005737	1/133	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8FBM8G	GO:0042052	1/133	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8FBM8G	GO:0007422	1/133	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8FBM8G	GO:0006915	1/133	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8FBM8G	GO:0007517	1/133	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8FBM8G	GO:0045924	1/133	regulation of female receptivity	biological_process	"Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8FBM8G	GO:0005634	1/133	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FBM8G	GO:0010468	1/133	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8WM7B5	GO:0005576	2/27	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8JDKNN	GO:0005576	1/126	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8JDKNN	GO:0008592	1/126	regulation of Toll signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8JDKNN	GO:0009620	1/126	response to fungus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
EOG8JDKNN	GO:0008045	1/126	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8JDKNN	GO:0006967	1/126	positive regulation of antifungal peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah]
EOG8JDKNN	GO:0008083	1/126	growth factor activity	molecular_function	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]
EOG8JDKNN	GO:0000578	1/126	embryonic axis specification	biological_process	"The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb]
EOG8JDKNN	GO:0019732	1/126	antifungal humoral response	biological_process	"An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8JDKNN	GO:0031640	1/126	killing of cells of other organism	biological_process	"Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add]
EOG8JDKNN	GO:0005615	1/126	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8JDKNN	GO:0031334	1/126	positive regulation of protein complex assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]
EOG8JDKNN	GO:0005125	1/126	cytokine activity	molecular_function	"Functions to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471]
EOG8JDKNN	GO:0007310	1/126	oocyte dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8JDKNN	GO:0008063	1/126	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8JDKNN	GO:0007311	1/126	maternal specification of dorsal/ventral axis, oocyte, germ-line encoded	biological_process	"Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8JDKNN	GO:0043234	1/126	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8JDKNN	GO:0050830	1/126	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG8JDKNN	GO:0005121	1/126	Toll binding	molecular_function	"Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb]
EOG8JDKNN	GO:0016015	1/126	morphogen activity	molecular_function	"Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient." [GOC:go_curators]
EOG8JDKNN	GO:0050832	1/126	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8JDKNN	GO:0045087	1/126	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8JDKNN	GO:0042803	1/126	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8JDKNN	GO:0006965	1/126	positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475]
EOG8JDKNN	GO:0006952	1/126	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8JDKNN	GO:0009953	1/126	dorsal/ventral pattern formation	biological_process	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8JDKNN	GO:0006955	1/126	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8JDKNN	GO:0009950	1/126	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8MKQX1	GO:0005524	53/167	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8MKQX1	GO:0004674	46/167	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8MKQX1	GO:0008353	6/167	RNA polymerase II carboxy-terminal domain kinase activity	molecular_function	"Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah]
EOG8MKQX1	GO:0051301	4/167	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8MKQX1	GO:0004672	3/167	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8MKQX1	GO:0009987	2/167	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8MKQX1	GO:0007067	2/167	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8MKQX1	GO:0000082	2/167	G1/S transition of mitotic cell cycle	biological_process	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]
EOG8MKQX1	GO:0000086	2/167	G2/M transition of mitotic cell cycle	biological_process	"The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle]
EOG8MKQX1	GO:0004693	2/167	cyclin-dependent protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]
EOG8MKQX1	GO:0006468	2/167	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8MKQX1	GO:0005875	2/167	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8MKQX1	GO:0005515	2/167	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8MKQX1	GO:0004713	1/167	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8MKQX1	GO:0022008	1/167	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8MKQX1	GO:0048142	1/167	germarium-derived cystoblast division	biological_process	"The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu, PMID:11131529]
EOG8MKQX1	GO:0032880	1/167	regulation of protein localization	biological_process	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]
EOG8MKQX1	GO:0044818	1/167	mitotic G2/M transition checkpoint	biological_process	"A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
EOG8MKQX1	GO:0006974	1/167	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8MKQX1	GO:0008315	1/167	meiotic G2/MI transition	biological_process	"The cell cycle process in which a cell progresses from meiotic prophase to metaphase I." [PMID:15088480]
EOG8MKQX1	GO:0007141	1/167	male meiosis I	biological_process	"A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah]
EOG8MKQX1	GO:0007283	1/167	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8MKQX1	GO:0007095	1/167	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8MKQX1	GO:0007259	1/167	JAK-STAT cascade	biological_process	"Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028]
EOG8MKQX1	GO:0007140	1/167	male meiosis	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
EOG8MKQX1	GO:0000278	1/167	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8MKQX1	GO:0055059	1/167	asymmetric neuroblast division	biological_process	"The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
EOG8MKQX1	GO:0007284	1/167	spermatogonial cell division	biological_process	"The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes)." [GOC:bf, GOC:pr, ISBN:0879694238]
EOG8MKQX1	GO:0005634	1/167	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RJJJF	GO:0000166	5/19	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8RJJJF	GO:0003676	5/19	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RV56H	GO:0005215	33/156	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8RV56H	GO:0016021	31/156	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RV56H	GO:0016020	3/156	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RV56H	GO:0005886	1/156	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8RV56H	GO:0055085	1/156	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8RV56H	GO:0007399	1/156	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8RV56H	GO:0006812	1/156	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8RV56H	GO:0007398	1/156	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG8RV56H	GO:0016337	1/156	single organismal cell-cell adhesion	biological_process	"The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb]
EOG8RV56H	GO:0007498	1/156	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8RV56H	GO:0015267	1/156	channel activity	molecular_function	"Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-]
EOG8RV56H	GO:0031410	1/156	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG8RV56H	GO:0005912	1/156	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8RV56H	GO:0046331	1/156	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8RV56H	GO:0044719	1/156	regulation of imaginal disc-derived wing size	biological_process	"Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
EOG8RV56H	GO:0030707	1/156	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8RV56H	GO:0007219	1/156	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8RV56H	GO:0005261	1/156	cation channel activity	molecular_function	"Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8RV56J	GO:0004527	5/83	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8RV56J	GO:0000176	1/83	nuclear exosome (RNase complex)	cellular_component	"Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]
EOG8RV56J	GO:0035327	1/83	transcriptionally active chromatin	cellular_component	"The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872]
EOG8RV56J	GO:0010468	1/83	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8RV56J	GO:0005652	1/83	nuclear lamina	cellular_component	"The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363]
EOG8RV56J	GO:0009022	1/83	tRNA nucleotidyltransferase activity	molecular_function	"Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate." [EC:2.7.7.56]
EOG8RV56J	GO:0005737	1/83	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RV56G	GO:0005634	1/66	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RV56G	GO:0004674	1/66	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8RV56G	GO:0043565	1/66	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8RV56G	GO:0005524	1/66	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8RV56G	GO:0003700	1/66	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8PZMP5	GO:0090207	1/83	regulation of triglyceride metabolic process	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb]
EOG8PZMP5	GO:0046890	1/83	regulation of lipid biosynthetic process	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
EOG8PZMP5	GO:0005783	1/83	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8PZMP5	GO:0042594	1/83	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8PZMP5	GO:0016042	1/83	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8PZMP5	GO:0016021	1/83	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PZMP5	GO:0010883	1/83	regulation of lipid storage	biological_process	"Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
EOG8PZMP5	GO:0046339	1/83	diacylglycerol metabolic process	biological_process	"The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [CHEBI:18035, GOC:curators]
EOG8PZMP5	GO:0005789	1/83	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8PZMP5	GO:0046473	1/83	phosphatidic acid metabolic process	biological_process	"The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732]
EOG8RV56C	GO:0045196	1/89	establishment or maintenance of neuroblast polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083]
EOG8RV56C	GO:0005515	1/89	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8RV56C	GO:0035003	1/89	subapical complex	cellular_component	"The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938]
EOG8RV56C	GO:0045179	1/89	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8RV56C	GO:0045186	1/89	zonula adherens assembly	biological_process	"Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf]
EOG8RV56C	GO:0006909	1/89	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8RV56C	GO:0045176	1/89	apical protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf]
EOG8RV56C	GO:0045197	1/89	establishment or maintenance of epithelial cell apical/basal polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]
EOG8RV56C	GO:0005938	1/89	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8RV56C	GO:0055059	1/89	asymmetric neuroblast division	biological_process	"The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
EOG8RV56C	GO:0016332	1/89	establishment or maintenance of polarity of embryonic epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah]
EOG8RV56C	GO:0006469	1/89	negative regulation of protein kinase activity	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
EOG8RV56C	GO:0060446	1/89	branching involved in open tracheal system development	biological_process	"The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph]
EOG8RV56C	GO:0001738	1/89	morphogenesis of a polarized epithelium	biological_process	"The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]
EOG8RV56C	GO:0007416	1/89	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG8RV56C	GO:0007155	1/89	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8RV56C	GO:0010592	1/89	positive regulation of lamellipodium assembly	biological_process	"Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG8RV56C	GO:0007309	1/89	oocyte axis specification	biological_process	"The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8RV56C	GO:0007298	1/89	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8RV56C	GO:0016324	1/89	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8RV56C	GO:0051491	1/89	positive regulation of filopodium assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG8RV56C	GO:0008360	1/89	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8RV56C	GO:0045200	1/89	establishment of neuroblast polarity	biological_process	"The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]
EOG8S1WN2	GO:0007015	2/68	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8S1WN2	GO:0016477	2/68	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG8S1WN2	GO:0007155	2/68	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8JDKPC	GO:0046872	4/31	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8JDKPC	GO:0003676	3/31	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89KJ6W	GO:0030036	9/39	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG89KJ6W	GO:0005856	9/39	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG80GG5K	GO:0016787	32/103	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG80GG5K	GO:0003948	11/103	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	molecular_function	"Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)." [EC:3.5.1.26, RHEA:11547]
EOG80GG5K	GO:0006517	8/103	protein deglycosylation	biological_process	"The removal of sugar residues from a glycosylated protein." [GOC:mah]
EOG80GG5K	GO:0008233	8/103	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG80GG5K	GO:0005764	8/103	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8GB9PD	GO:0005634	1/64	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GB9PD	GO:0000786	1/64	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8GB9PD	GO:0003677	1/64	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GB9PD	GO:0006334	1/64	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8SBHD0	GO:0006810	21/76	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8SBHD0	GO:0005622	21/76	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8SBHD0	GO:0008526	1/76	phosphatidylinositol transporter activity	molecular_function	"Enables the directed movement of phosphatidylinositol into, out of or within a cell, or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:ai, ISBN:0198506732]
EOG8SBHD0	GO:0005737	1/76	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SBHD0	GO:0008289	1/76	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG8SBHD0	GO:0015914	1/76	phospholipid transport	biological_process	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]
EOG8SBHD0	GO:0007165	1/76	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG80GG5R	GO:0003824	22/111	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG80GG5R	GO:0004739	4/111	pyruvate dehydrogenase (acetyl-transferring) activity	molecular_function	"Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1]
EOG80GG5R	GO:0005875	1/111	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG80GG5R	GO:0031122	1/111	cytoplasmic microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
EOG80GG5R	GO:0005739	1/111	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG80GG5R	GO:0005811	1/111	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8K3PBX	GO:0004871	4/42	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8K3PBX	GO:0004842	4/42	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8K3PBX	GO:0005634	4/42	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8K3PBX	GO:0005509	4/42	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8K3PBX	GO:0007166	4/42	cell surface receptor signaling pathway	biological_process	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
EOG8K3PBX	GO:0023051	4/42	regulation of signaling	biological_process	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
EOG8M3CQ9	GO:0009966	31/93	regulation of signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]
EOG8M3CQ9	GO:0022008	1/93	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8K3PBV	GO:0003723	24/85	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8K3PBV	GO:0005737	24/85	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8K3PBV	GO:0003824	24/85	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8K3PBV	GO:0006355	24/85	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8M3CQ7	GO:0000166	20/79	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8M3CQ7	GO:0003723	13/79	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8M3CQ7	GO:0006396	13/79	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8M3CQ7	GO:0005634	13/79	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8M3CQ7	GO:0030529	13/79	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8M3CQ7	GO:0019013	2/79	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8M3CQ4	GO:0003964	10/341	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8M3CQ4	GO:0003723	9/341	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8M3CQ4	GO:0005198	3/341	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8M3CQ4	GO:0005882	3/341	intermediate filament	cellular_component	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
EOG8M3CQ4	GO:0015074	2/341	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8M3CQ4	GO:0003677	2/341	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8M3CQ4	GO:0003676	2/341	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M3CQ4	GO:0007155	1/341	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8M3CQ4	GO:0009007	1/341	site-specific DNA-methyltransferase (adenine-specific) activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72]
EOG8M3CQ4	GO:0046872	1/341	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8M3CQ4	GO:0006310	1/341	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8M3CQ4	GO:0008168	1/341	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8K3PBS	GO:0016740	5/476	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8K3PBS	GO:0016021	5/476	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8K3PBS	GO:0003676	1/476	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K3PBS	GO:0008270	1/476	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8K3PBD	GO:0005840	22/91	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8K3PBD	GO:0007052	1/91	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8K3PBD	GO:0000022	1/91	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8K3PBD	GO:0051298	1/91	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8K3PBD	GO:0003723	1/91	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8K3PBD	GO:0035073	1/91	pupariation	biological_process	"The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
EOG8K3PBD	GO:0003735	1/91	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8GF5X5	GO:0003676	4/38	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GF5X5	GO:0008270	4/38	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GF5X2	GO:0019028	2/54	viral capsid	cellular_component	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
EOG8GF5X2	GO:0005198	2/54	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8QJV1Z	GO:0007155	24/111	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8QJV1Z	GO:0006030	20/111	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8QJV1Z	GO:0005576	20/111	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8QJV1Z	GO:0008061	20/111	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8QJV1Z	GO:0042060	1/111	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8QJV1Z	GO:0047712	1/111	Cypridina-luciferin 2-monooxygenase activity	molecular_function	"Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light." [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN]
EOG8QJV1Z	GO:0042381	1/111	hemolymph coagulation	biological_process	"Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949]
EOG8QJV1Z	GO:0042803	1/111	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8QJV1Z	GO:0003676	1/111	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QJV1Z	GO:0007599	1/111	hemostasis	biological_process	"The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732]
EOG8QJV1Z	GO:0008270	1/111	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8HMMS1	GO:0005634	1/15	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HMMS1	GO:0003700	1/15	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8RZ1D2	GO:0003677	5/86	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RZ1D2	GO:0005634	5/86	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GF5XB	GO:0003676	4/39	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GF5XB	GO:0046872	4/39	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8J13Q7	GO:0020037	23/84	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8J13Q7	GO:0005576	2/84	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8J13Q7	GO:0032440	1/84	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8M3CQJ	GO:0007498	1/145	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG81NX2V	GO:0006351	9/45	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG81NX2V	GO:0005634	9/45	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81NX2V	GO:0003677	9/45	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81NX2V	GO:0005667	9/45	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG81NX2V	GO:0003700	9/45	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG89361X	GO:0016787	1/21	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8SBHDJ	GO:0004385	24/92	guanylate kinase activity	molecular_function	"Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8]
EOG8SBHDJ	GO:0006163	24/92	purine nucleotide metabolic process	biological_process	"The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
EOG8SBHDJ	GO:0017111	2/92	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8SBHDJ	GO:0005524	2/92	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SBHDG	GO:0016028	1/76	rhabdomere	cellular_component	"The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774]
EOG8TTJZD	GO:0016021	1/90	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TTJZD	GO:0030246	1/90	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8TTJZD	GO:0008039	1/90	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8TTJZD	GO:0050832	1/90	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG883GKV	GO:0003677	1/93	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RNDQ5	GO:0008270	2/29	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RNDQ5	GO:0003676	2/29	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RNDQ5	GO:0006511	1/29	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8ZPHB4	GO:0005840	6/73	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8ZPHB4	GO:0005763	1/73	mitochondrial small ribosomal subunit	cellular_component	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
EOG8ZPHB4	GO:0003735	1/73	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8ZPHB4	GO:0006412	1/73	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8RNDQ6	GO:0016491	31/111	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8RNDQ6	GO:0004745	2/111	retinol dehydrogenase activity	molecular_function	"Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [EC:1.1.1.105]
EOG8RNDQ6	GO:0004022	1/111	alcohol dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
EOG8RBT0G	GO:0009072	27/84	aromatic amino acid family metabolic process	biological_process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]
EOG8RBT0G	GO:0003868	27/84	4-hydroxyphenylpyruvate dioxygenase activity	molecular_function	"Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27]
EOG8RBT0G	GO:0046872	22/84	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RBT0G	GO:0004462	1/84	lactoylglutathione lyase activity	molecular_function	"Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19072]
EOG880M9T	GO:0003676	8/38	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG880M9T	GO:0046872	2/38	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG880M9T	GO:0003677	1/38	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X3KJF	GO:0016301	1/15	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8KPWSH	GO:0007059	2/176	chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
EOG8KPWSH	GO:0005515	1/176	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8PK4P6	GO:0046872	24/117	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8PK4P6	GO:0003743	1/117	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8PK4P6	GO:0006413	1/117	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG8PK4P5	GO:0016021	1/40	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81RS89	GO:0055085	250/817	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG81RS89	GO:0005215	250/817	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG81RS89	GO:0016021	249/817	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81RS89	GO:0016020	2/817	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG81RS89	GO:0006814	1/817	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG81RS89	GO:0051780	1/817	behavioral response to nutrient	biological_process	"Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus." [GOC:ai]
EOG81RS89	GO:0008343	1/817	adult feeding behavior	biological_process	"Feeding behavior in a fully developed and mature organism." [GOC:mah]
EOG81RS89	GO:0016323	1/817	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG81RS89	GO:0015293	1/817	symporter activity	molecular_function	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
EOG81RS89	GO:0007156	1/817	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG81RS89	GO:0005509	1/817	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8RZ1D5	GO:0060271	7/94	cilium morphogenesis	biological_process	"A process that is carried out at the cellular level and in which the structure of a cilium is organized." [GOC:BHF, GOC:dph]
EOG8RZ1D5	GO:0005930	7/94	axoneme	cellular_component	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]
EOG8RZ1D5	GO:0045502	7/94	dynein binding	molecular_function	"Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules." [GOC:bf]
EOG8RZ1D5	GO:0007268	1/94	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8RZ1D8	GO:0003676	55/523	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RZ1D8	GO:0016301	3/523	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8RZ1D8	GO:0046872	2/523	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RZ1D8	GO:0005524	1/523	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8RZ1D8	GO:0004743	1/523	pyruvate kinase activity	molecular_function	"Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40]
EOG8RZ1D8	GO:0000287	1/523	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8RZ1D8	GO:0003723	1/523	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RZ1D8	GO:0008270	1/523	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RZ1D8	GO:0006096	1/523	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8RZ1D8	GO:0030955	1/523	potassium ion binding	molecular_function	"Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah]
EOG8RZ1D8	GO:0004672	1/523	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8RZ1D8	GO:0003964	1/523	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG808QQ0	GO:0016020	51/173	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG808QQ0	GO:0008324	51/173	cation transmembrane transporter activity	molecular_function	"Enables the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
EOG808QQ0	GO:0003677	5/173	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG808QQ0	GO:0006281	5/173	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG808QQ2	GO:0005634	27/106	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG808QQ2	GO:0003677	27/106	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG808QQ2	GO:0003700	1/106	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG808QQ2	GO:0008049	1/106	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG808QQ2	GO:0048813	1/106	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG808QQ2	GO:0045924	1/106	regulation of female receptivity	biological_process	"Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:go_curators, GOC:tb]
EOG808QQ2	GO:0000122	1/106	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG808QQ2	GO:0007517	1/106	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG808QQ2	GO:0070491	1/106	repressing transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH]
EOG808QQ2	GO:0048477	1/106	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG808QQ2	GO:0007435	1/106	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG808QQ2	GO:0000976	1/106	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG808QQ2	GO:0007411	1/106	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG808QQ2	GO:0006351	1/106	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG808QQ2	GO:0045893	1/106	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG808QQ2	GO:0009880	1/106	embryonic pattern specification	biological_process	"The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
EOG808QQ2	GO:0009952	1/106	anterior/posterior pattern specification	biological_process	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG808QQ2	GO:0042063	1/106	gliogenesis	biological_process	"The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid]
EOG808QQ2	GO:0007431	1/106	salivary gland development	biological_process	"The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044]
EOG808QQ3	GO:0006099	28/94	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG808QQ3	GO:0004149	28/94	dihydrolipoyllysine-residue succinyltransferase activity	molecular_function	"Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61]
EOG808QQ3	GO:0045252	28/94	oxoglutarate dehydrogenase complex	cellular_component	"A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [MetaCyc:CPLX66-42, PMID:10848975]
EOG808QQ3	GO:0005811	1/94	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG808QQ3	GO:0004742	1/94	dihydrolipoyllysine-residue acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12]
EOG808QQ3	GO:0016746	1/94	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG808QQ3	GO:0005875	1/94	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8ZW7RX	GO:0016021	44/122	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZW7RX	GO:0006810	39/122	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8ZW7RX	GO:0055085	4/122	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8ZW7RX	GO:0006310	2/122	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8ZW7RX	GO:0015074	2/122	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8ZW7RX	GO:0003677	2/122	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8ZW7RX	GO:0035435	1/122	phosphate ion transmembrane transport	biological_process	"The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
EOG8ZW7RX	GO:0015114	1/122	phosphate ion transmembrane transporter activity	molecular_function	"Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai]
EOG8ZW7RX	GO:0005811	1/122	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8ZW7RX	GO:0048190	1/122	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8ZW7RX	GO:0006817	1/122	phosphate ion transport	biological_process	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8ZW7RX	GO:0005743	1/122	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG86Q981	GO:0008081	10/74	phosphoric diester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]
EOG86Q981	GO:0003824	10/74	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG86Q981	GO:0046872	10/74	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG86Q981	GO:0008168	5/74	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG86Q981	GO:0042594	1/74	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG86Q981	GO:0008893	1/74	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	molecular_function	"Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate." [EC:3.1.7.2]
EOG86Q981	GO:0016787	1/74	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG86Q981	GO:0015971	1/74	guanosine tetraphosphate catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai]
EOG86Q981	GO:0008728	1/74	GTP diphosphokinase activity	molecular_function	"Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate." [EC:2.7.6.5]
EOG81RS8Z	GO:0008270	23/84	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RZ1DV	GO:0003677	10/252	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RZ1DV	GO:0015074	5/252	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8RZ1DV	GO:0006310	5/252	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8RZ1DV	GO:0003676	1/252	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RZ1DV	GO:0003723	1/252	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RZ1DV	GO:0003964	1/252	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8642RT	GO:0006260	29/114	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8642RT	GO:0005524	28/114	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8642RT	GO:0005971	28/114	ribonucleoside-diphosphate reductase complex	cellular_component	"An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor." [BRENDA:1.17.4.1]
EOG8642RT	GO:0004748	28/114	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	molecular_function	"Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1]
EOG8642RT	GO:0051539	1/114	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8642RT	GO:0016992	1/114	lipoate synthase activity	molecular_function	"Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl." [EC:2.8.1.8, PMID:18307109]
EOG8642RT	GO:0055114	1/114	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8642RT	GO:0006919	1/114	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
EOG8642RT	GO:0042246	1/114	tissue regeneration	biological_process	"The regrowth of lost or destroyed tissues." [GOC:curators]
EOG8642RT	GO:0009263	1/114	deoxyribonucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
EOG8RZ1DX	GO:0006633	132/423	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8RZ1DX	GO:0016021	132/423	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RZ1DX	GO:0016717	92/423	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]
EOG8RZ1DX	GO:0004768	40/423	stearoyl-CoA 9-desaturase activity	molecular_function	"Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1]
EOG8RZ1DX	GO:0005783	36/423	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8RZ1DX	GO:0005506	35/423	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8RZ1DX	GO:0060179	1/423	male mating behavior	biological_process	"The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb]
EOG8RZ1DX	GO:0042811	1/423	pheromone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]
EOG8RZ1DX	GO:0004984	1/423	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8RZ1DX	GO:0010506	1/423	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8RZ1DX	GO:0007619	1/423	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG8RZ1DX	GO:0005811	1/423	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8RZ1DX	GO:0048047	1/423	mating behavior, sex discrimination	biological_process	"The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700]
EOG8RZ1DX	GO:0042810	1/423	pheromone metabolic process	biological_process	"The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]
EOG8RZ1DX	GO:0042593	1/423	glucose homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]
EOG8RZ1DX	GO:0070328	1/423	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG8RZ1DX	GO:0000281	1/423	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8RZ1DX	GO:0006909	1/423	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8RZ1DX	GO:0031410	1/423	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG8RZ1DX	GO:0019216	1/423	regulation of lipid metabolic process	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
EOG8RZ1DX	GO:0005549	1/423	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8RZ1DX	GO:0009744	1/423	response to sucrose	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl]
EOG8RZ1DX	GO:0006723	1/423	cuticle hydrocarbon biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai]
EOG81RS8T	GO:0050660	24/79	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG81RS8T	GO:0017150	24/79	tRNA dihydrouridine synthase activity	molecular_function	"Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710]
EOG8ZW7R8	GO:0015095	1/94	magnesium ion transmembrane transporter activity	molecular_function	"Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:dgf]
EOG8ZW7R8	GO:0071011	1/94	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8ZW7R8	GO:0016020	1/94	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8ZW7R8	GO:0005685	1/94	U1 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U1." [GOC:krc, GOC:mah]
EOG8ZW7R8	GO:0000398	1/94	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8ZPHBR	GO:0035299	21/82	inositol pentakisphosphate 2-kinase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H(+)." [EC:2.7.1.158, RHEA:20316]
EOG8ZPHBR	GO:0005524	21/82	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZPHBR	GO:0032958	1/82	inositol phosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, CHEBI:25448, GOC:mah]
EOG8KPWS4	GO:0016021	32/146	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KPWS4	GO:0055085	19/146	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8KPWS4	GO:0006839	10/146	mitochondrial transport	biological_process	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]
EOG8KPWS4	GO:0031966	10/146	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG8KPWS4	GO:0006810	3/146	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8KPWS4	GO:0005743	1/146	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8KPWS4	GO:0007605	1/146	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8KPWS4	GO:0019222	1/146	regulation of metabolic process	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
EOG8KPWS4	GO:0005215	1/146	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8RBT07	GO:0005737	1/83	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RBT07	GO:0030718	1/83	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8RBT07	GO:0007126	1/83	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8RBT07	GO:0007141	1/83	male meiosis I	biological_process	"A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah]
EOG8RBT07	GO:0048137	1/83	spermatocyte division	biological_process	"The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238]
EOG8RBT07	GO:0007283	1/83	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8RBT07	GO:0046872	1/83	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RBT07	GO:0001745	1/83	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8RBT07	GO:0051301	1/83	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8RBT07	GO:0008315	1/83	meiotic G2/MI transition	biological_process	"The cell cycle process in which a cell progresses from meiotic prophase to metaphase I." [PMID:15088480]
EOG8RBT07	GO:0004519	1/83	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8RBT07	GO:0048132	1/83	female germ-line stem cell asymmetric division	biological_process	"The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu]
EOG8RBT07	GO:0005634	1/83	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RBT07	GO:0000212	1/83	meiotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah]
EOG8RBT07	GO:0051078	1/83	meiotic nuclear envelope disassembly	biological_process	"The cell cycle process in which the controlled breakdown of the nuclear envelope during meiotic cell division occurs." [GOC:bf]
EOG8RBT07	GO:0007140	1/83	male meiosis	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
EOG8RBT07	GO:0007067	1/83	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8RNDQC	GO:0016021	30/176	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RNDQC	GO:0006633	28/176	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8RNDQC	GO:0016740	28/176	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8RNDQC	GO:0016491	26/176	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8RNDQC	GO:0009922	2/176	fatty acid elongase activity	molecular_function	"Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb]
EOG8RNDQC	GO:0030497	2/176	fatty acid elongation	biological_process	"The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094]
EOG8RNDQC	GO:0070524	2/176	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	molecular_function	"Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146]
EOG8RNDQC	GO:0042759	1/176	long-chain fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:go_curators]
EOG8RNDQC	GO:0042811	1/176	pheromone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]
EOG8RNDQC	GO:0018454	1/176	acetoacetyl-CoA reductase activity	molecular_function	"Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36]
EOG8RNDQC	GO:0019368	1/176	fatty acid elongation, unsaturated fatty acid	biological_process	"Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah]
EOG8RNDQC	GO:0004316	1/176	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
EOG8N333F	GO:0030170	53/186	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8N333F	GO:0009058	51/186	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG8N333F	GO:0006520	51/186	cellular amino acid metabolic process	biological_process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]
EOG8N333F	GO:0080130	37/186	L-phenylalanine:2-oxoglutarate aminotransferase activity	molecular_function	"Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate." [GOC:pmn_curators, PMID:18394996]
EOG8N333F	GO:0004069	37/186	L-aspartate:2-oxoglutarate aminotransferase activity	molecular_function	"Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1]
EOG8N333F	GO:0008483	16/186	transaminase activity	molecular_function	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]
EOG8N333F	GO:0006537	2/186	glutamate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
EOG8N333F	GO:0000178	2/186	exosome (RNase complex)	cellular_component	"Complex of 3'-5' exoribonucleases." [PMID:10465791]
EOG8N333F	GO:0003723	2/186	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8N333F	GO:0007416	1/186	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG8N333F	GO:0045213	1/186	neurotransmitter receptor metabolic process	biological_process	"The chemical reactions and pathways involving neurotransmitter receptors." [GOC:go_curators]
EOG8N333F	GO:0005777	1/186	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8N333F	GO:0005811	1/186	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8N333F	GO:0005739	1/186	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8N333F	GO:0007476	1/186	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8G1PX8	GO:0004747	35/98	ribokinase activity	molecular_function	"Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [EC:2.7.1.15]
EOG8G1PX8	GO:0006014	35/98	D-ribose metabolic process	biological_process	"The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732]
EOG8G1PX8	GO:0003676	1/98	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8G1PX8	GO:0016829	1/98	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8G1PX8	GO:0055085	1/98	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8G1PX8	GO:0016021	1/98	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G1PX8	GO:0000166	1/98	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8TF30K	GO:0005634	29/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TF30K	GO:0005667	29/96	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8TF30K	GO:0007179	29/96	transforming growth factor beta receptor signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
EOG8TF30K	GO:0006351	28/96	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8TF30K	GO:0003700	28/96	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8TF30K	GO:0045887	1/96	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8TF30K	GO:0000980	1/96	RNA polymerase II distal enhancer sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH]
EOG8TF30K	GO:0001745	1/96	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8TF30K	GO:0001102	1/96	RNA polymerase II activating transcription factor binding	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription." [GOC:txnOH]
EOG8TF30K	GO:0042078	1/96	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG8TF30K	GO:0007488	1/96	histoblast morphogenesis	biological_process	"The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238]
EOG8TF30K	GO:0007391	1/96	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8TF30K	GO:0045705	1/96	negative regulation of salivary gland boundary specification	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb]
EOG8TF30K	GO:0030718	1/96	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8TF30K	GO:0005737	1/96	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8TF30K	GO:0035290	1/96	trunk segmentation	biological_process	"Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402]
EOG8TF30K	GO:0006366	1/96	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8TF30K	GO:0003705	1/96	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG8TF30K	GO:0043565	1/96	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8TF30K	GO:0006357	1/96	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8TF30K	GO:0048100	1/96	wing disc anterior/posterior pattern formation	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing." [GOC:jid, PMID:10625531]
EOG8TF30K	GO:0010629	1/96	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8TF30K	GO:0045595	1/96	regulation of cell differentiation	biological_process	"Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]
EOG8TF30K	GO:0005515	1/96	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8TF30K	GO:0061353	1/96	BMP signaling pathway involved in Malpighian tubule cell chemotaxis	biological_process	"A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the directed movement of a Malpighian tubule cell toward a stimulus, thereby contributing to the shaping of the tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG8TF30K	GO:2000134	1/96	negative regulation of G1/S transition of mitotic cell cycle	biological_process	"Any cell cycle regulatory process that prevents the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]
EOG8TF30K	GO:0007507	1/96	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8TF30K	GO:0035019	1/96	somatic stem cell population maintenance	biological_process	"Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089]
EOG8TF30K	GO:0007476	1/96	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8TF30K	GO:0007480	1/96	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8TF30K	GO:0007424	1/96	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8TF30K	GO:0046872	1/96	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TF30K	GO:0045944	1/96	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8TF30K	GO:0030707	1/96	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8TF30K	GO:0001105	1/96	RNA polymerase II transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8TF30K	GO:0008586	1/96	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG8TF30K	GO:0000976	1/96	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8TF30P	GO:0005524	74/266	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8TF30P	GO:0016021	72/266	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TF30P	GO:0005024	59/266	transforming growth factor beta-activated receptor activity	molecular_function	"Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]
EOG8TF30P	GO:0004702	9/266	receptor signaling protein serine/threonine kinase activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah]
EOG8TF30P	GO:0004675	9/266	transmembrane receptor protein serine/threonine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30]
EOG8TF30P	GO:0004672	3/266	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8TF30P	GO:0007179	3/266	transforming growth factor beta receptor signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
EOG8TF30P	GO:0006468	3/266	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8TF30P	GO:0004674	3/266	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8TF30P	GO:0007476	3/266	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8TF30P	GO:0005025	3/266	transforming growth factor beta receptor activity, type I	molecular_function	"Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals." [GOC:mah, Reactome:REACT_6945.1]
EOG8TF30P	GO:0042078	2/266	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG8TF30P	GO:0007448	2/266	anterior/posterior pattern specification, imaginal disc	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238]
EOG8TF30P	GO:0008101	2/266	decapentaplegic signaling pathway	biological_process	"A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:sart, PMID:17428827]
EOG8TF30P	GO:0045887	2/266	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8TF30P	GO:0030707	2/266	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8TF30P	GO:0007304	2/266	chorion-containing eggshell formation	biological_process	"The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8TF30P	GO:0009953	2/266	dorsal/ventral pattern formation	biological_process	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8TF30P	GO:0030509	2/266	BMP signaling pathway	biological_process	"A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PR:000000034]
EOG8TF30P	GO:0005515	2/266	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8TF30P	GO:0001745	2/266	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8TF30P	GO:0030718	2/266	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8TF30P	GO:0005886	2/266	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8TF30P	GO:0010862	1/266	positive regulation of pathway-restricted SMAD protein phosphorylation	biological_process	"Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph, GOC:tb]
EOG8TF30P	GO:0050431	1/266	transforming growth factor beta binding	molecular_function	"Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types." [ISBN:0198506732]
EOG8TF30P	GO:0045824	1/266	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG8TF30P	GO:0045705	1/266	negative regulation of salivary gland boundary specification	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb]
EOG8TF30P	GO:0007488	1/266	histoblast morphogenesis	biological_process	"The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238]
EOG8TF30P	GO:0007391	1/266	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8TF30P	GO:0030514	1/266	negative regulation of BMP signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators]
EOG8TF30P	GO:0008358	1/266	maternal determination of anterior/posterior axis, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8TF30P	GO:0001763	1/266	morphogenesis of a branching structure	biological_process	"The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544]
EOG8TF30P	GO:0007165	1/266	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8TF30P	GO:0035215	1/266	genital disc development	biological_process	"Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318]
EOG8TF30P	GO:0016361	1/266	activin receptor activity, type I	molecular_function	"Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals." [GOC:mah, PMID:8622651]
EOG8TF30P	GO:0048179	1/266	activin receptor complex	cellular_component	"A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed." [PMID:8307945, PMID:8622651]
EOG8TF30P	GO:0040018	1/266	positive regulation of multicellular organism growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8TF30P	GO:0030513	1/266	positive regulation of BMP signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators]
EOG8TF30P	GO:0045927	1/266	positive regulation of growth	biological_process	"Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
EOG8TF30P	GO:0007346	1/266	regulation of mitotic cell cycle	biological_process	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8TF30P	GO:0008582	1/266	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8TF30P	GO:0030512	1/266	negative regulation of transforming growth factor beta receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway." [GOC:mah]
EOG8TF30P	GO:0007181	1/266	transforming growth factor beta receptor complex assembly	biological_process	"The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex." [GOC:jl, Reactome:REACT_7425, Wikipedia:TGF_beta_signaling_pathway]
EOG8TF30P	GO:0010629	1/266	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8TF30P	GO:0005887	1/266	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TF30P	GO:0046845	1/266	branched duct epithelial cell fate determination, open tracheal system	biological_process	"Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581]
EOG8TF30P	GO:0007455	1/266	eye-antennal disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8TF30P	GO:0007411	1/266	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8TF30P	GO:0048666	1/266	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8TF30P	GO:0004703	1/266	G-protein coupled receptor kinase activity	molecular_function	"Catalysis of the reaction: ATP + G-protein coupled receptor = ADP + G-protein coupled receptor phosphate." [GOC:dph]
EOG8TF30P	GO:0048185	1/266	activin binding	molecular_function	"Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits." [GOC:jid, GOC:mah]
EOG8TF30P	GO:0007300	1/266	ovarian nurse cell to oocyte transport	biological_process	"Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8TF30P	GO:0032924	1/266	activin receptor signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:rl, GOC:signaling]
EOG8TF30P	GO:0007015	1/266	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8TF30P	GO:0050829	1/266	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8TF30P	GO:0048477	1/266	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8TF30P	GO:0061327	1/266	anterior Malpighian tubule development	biological_process	"The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG8TF30P	GO:0009411	1/266	response to UV	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]
EOG8TF30P	GO:0048813	1/266	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8TF30P	GO:0007274	1/266	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8TF30P	GO:0090254	1/266	cell elongation involved in imaginal disc-derived wing morphogenesis	biological_process	"The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8TF30P	GO:0007507	1/266	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8TF30P	GO:0007424	1/266	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8TF30P	GO:0005769	1/266	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG8TF30P	GO:0048636	1/266	positive regulation of muscle organ development	biological_process	"Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators]
EOG8TF30P	GO:0035222	1/266	wing disc pattern formation	biological_process	"The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf]
EOG8TF30P	GO:0005771	1/266	multivesicular body	cellular_component	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]
EOG8TF30P	GO:0022407	1/266	regulation of cell-cell adhesion	biological_process	"Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete]
EOG8TF30P	GO:0006357	1/266	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8TF30P	GO:0048100	1/266	wing disc anterior/posterior pattern formation	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing." [GOC:jid, PMID:10625531]
EOG8TF30P	GO:0045570	1/266	regulation of imaginal disc growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators]
EOG8TF30P	GO:0016319	1/266	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8TF30P	GO:0016477	1/266	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG8TF30P	GO:0045595	1/266	regulation of cell differentiation	biological_process	"Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]
EOG8TF30P	GO:0007405	1/266	neuroblast proliferation	biological_process	"The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart]
EOG80ZTCF	GO:0003676	49/794	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80ZTCF	GO:0003887	26/794	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG80ZTCF	GO:0000166	26/794	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG80ZTCF	GO:0046872	20/794	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80ZTCF	GO:0008408	11/794	3'-5' exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]
EOG80ZTCF	GO:0003677	11/794	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80ZTCF	GO:0009103	1/794	lipopolysaccharide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai, GOC:mr]
EOG80ZTCF	GO:0006353	1/794	DNA-templated transcription, termination	biological_process	"The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161]
EOG80ZTCN	GO:0004843	35/93	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG80ZTCN	GO:0005622	34/93	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG80ZTCN	GO:0006511	34/93	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG80ZTCN	GO:0008242	30/93	omega peptidase activity	molecular_function	"Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-]
EOG80ZTCN	GO:0004221	3/93	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG80ZTCN	GO:0043161	1/93	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG80ZTCN	GO:0005838	1/93	proteasome regulatory particle	cellular_component	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]
EOG80ZTCN	GO:0022008	1/93	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG80ZTCQ	GO:0003678	1/149	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG80ZTCQ	GO:0000723	1/149	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG80ZTCQ	GO:0006281	1/149	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG80ZTCQ	GO:0003676	1/149	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80ZTCQ	GO:0003723	1/149	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG80ZTCQ	GO:0003964	1/149	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG80ZTCS	GO:0016021	2/73	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PZMMK	GO:0004970	24/96	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8PZMMK	GO:0005234	24/96	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8PZMMK	GO:0030054	23/96	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8PZMMK	GO:0016021	23/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PZMMK	GO:0045211	23/96	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8PZMMK	GO:0071683	1/96	sensory dendrite	cellular_component	"A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron." [GOC:dos, GOC:kmv, GOC:mah]
EOG8PZMMK	GO:0034220	1/96	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8PZMMK	GO:0008328	1/96	ionotropic glutamate receptor complex	cellular_component	"A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
EOG8PZMMK	GO:0035249	1/96	synaptic transmission, glutamatergic	biological_process	"The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv]
EOG8PZMMK	GO:0016020	1/96	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8PZMMK	GO:0005929	1/96	cilium	cellular_component	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:kmv, GOC:vw, ISBN:0198547684]
EOG8PZMMK	GO:0007608	1/96	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8PZMMK	GO:0015276	1/96	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8PZMMK	GO:0050907	1/96	detection of chemical stimulus involved in sensory perception	biological_process	"The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
EOG8PZMMK	GO:0035235	1/96	ionotropic glutamate receptor signaling pathway	biological_process	"A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732]
EOG8Z919W	GO:0006887	3/98	exocytosis	biological_process	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
EOG8Z919W	GO:0005737	3/98	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Z919W	GO:0048278	3/98	vesicle docking	biological_process	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]
EOG8Z919W	GO:0000139	1/98	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8Z919W	GO:0015031	1/98	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8Z919V	GO:0008241	93/395	peptidyl-dipeptidase activity	molecular_function	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]
EOG8Z919V	GO:0016020	92/395	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Z919V	GO:0008237	91/395	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8Z919V	GO:0004180	14/395	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8Z919V	GO:0005615	2/395	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8Z919V	GO:0016491	2/395	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8Z919V	GO:0006508	2/395	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8Z919V	GO:0045938	1/395	positive regulation of circadian sleep/wake cycle, sleep	biological_process	"Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators]
EOG8Z919V	GO:0007289	1/395	spermatid nucleus differentiation	biological_process	"The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah]
EOG8Z919V	GO:0009609	1/395	response to symbiotic bacterium	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism." [GOC:hb, ISBN:0198506732]
EOG8Z919V	GO:0005576	1/395	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Z919V	GO:0046872	1/395	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z919V	GO:0004222	1/395	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8Z919V	GO:0007291	1/395	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8Z919V	GO:0007507	1/395	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8Z919V	GO:0003700	1/395	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z919V	GO:0016021	1/395	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z919V	GO:0005634	1/395	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z919V	GO:0005515	1/395	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8Z919V	GO:0030431	1/395	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8Z919V	GO:0007552	1/395	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG8Z919V	GO:0008270	1/395	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Z919V	GO:0043565	1/395	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8X0Q90	GO:0000398	1/73	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8X0Q90	GO:0030529	1/73	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8X0Q90	GO:0005515	1/73	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8X0Q90	GO:0019013	1/73	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8X0Q90	GO:0030532	1/73	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8X0Q90	GO:0005688	1/73	U6 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U6." [GOC:krc, GOC:mah]
EOG8X0Q90	GO:0005681	1/73	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8Z919X	GO:0008270	22/86	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Z919X	GO:0016787	22/86	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8Z919X	GO:0003824	2/86	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8MWBNK	GO:0016788	2/98	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG8MWBNK	GO:0003678	1/98	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8MWBNK	GO:0000723	1/98	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8MWBNK	GO:0006281	1/98	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8S1WNQ	GO:0046872	2/54	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DFS31	GO:0046872	23/98	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DFS31	GO:0045570	1/98	regulation of imaginal disc growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators]
EOG8DFS31	GO:0003714	1/98	transcription corepressor activity	molecular_function	"Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8DFS31	GO:0007476	1/98	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8DFS31	GO:0006886	1/98	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8DFS31	GO:0008345	1/98	larval locomotory behavior	biological_process	"Locomotory behavior in a larval (immature) organism." [GOC:ai]
EOG8DFS31	GO:0090389	1/98	phagosome-lysosome fusion involved in apoptotic cell clearance	biological_process	"The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb]
EOG8DFS31	GO:0048190	1/98	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8DFS31	GO:0005547	1/98	phosphatidylinositol-3,4,5-trisphosphate binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl]
EOG8DFS31	GO:0045335	1/98	phagocytic vesicle	cellular_component	"A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]
EOG8DFS31	GO:0007412	1/98	axon target recognition	biological_process	"The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437]
EOG8DFS31	GO:0007411	1/98	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8DFS31	GO:0000122	1/98	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8DFS31	GO:0045879	1/98	negative regulation of smoothened signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG8DFS31	GO:0005634	1/98	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SN45Q	GO:0004386	1/6	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8SN45Q	GO:0005524	1/6	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8J9QDC	GO:0016972	54/120	thiol oxidase activity	molecular_function	"Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O." [EC:1.8.3.2]
EOG8J9QDC	GO:0045454	51/120	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8J9QDC	GO:0005615	3/120	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8J9QDC	GO:0032504	3/120	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8J9QDC	GO:0016853	2/120	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8J9QDC	GO:0005576	1/120	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8J9QDC	GO:0046872	1/120	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8J9QDC	GO:0016491	1/120	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8X99XP	GO:0005975	74/237	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8X99XP	GO:0004563	73/237	beta-N-acetylhexosaminidase activity	molecular_function	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]
EOG8X99XP	GO:0016231	3/237	beta-N-acetylglucosaminidase activity	molecular_function	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN]
EOG8X99XP	GO:0005886	3/237	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8X99XP	GO:0003700	1/237	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8X99XP	GO:0007420	1/237	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG8X99XP	GO:0005634	1/237	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X99XP	GO:0016021	1/237	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X99XP	GO:0006491	1/237	N-glycan processing	biological_process	"The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198]
EOG8X99XP	GO:0005770	1/237	late endosome	cellular_component	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
EOG8X99XP	GO:0005615	1/237	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8X99XP	GO:0044130	1/237	negative regulation of growth of symbiont in host	biological_process	"Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
EOG8X99XP	GO:0032504	1/237	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8X99XP	GO:0043565	1/237	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8X99XQ	GO:0032007	22/81	negative regulation of TOR signaling	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8X99XQ	GO:0048011	22/81	neurotrophin TRK receptor signaling pathway	biological_process	"A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:ceb, GOC:jc, GOC:signaling, PMID:12065629, Wikipedia:Trk_receptor]
EOG8X99XQ	GO:0030178	1/81	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8X99XQ	GO:0048749	1/81	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8X99XQ	GO:0035214	1/81	eye-antennal disc development	biological_process	"Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8X99XQ	GO:0045570	1/81	regulation of imaginal disc growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators]
EOG8X99XQ	GO:0046329	1/81	negative regulation of JNK cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8X99XQ	GO:0038202	1/81	TORC1 signaling	biological_process	"A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]
EOG8X99XQ	GO:0007219	1/81	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8X99XQ	GO:0043069	1/81	negative regulation of programmed cell death	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
EOG8X99XQ	GO:0005737	1/81	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8G1PXN	GO:0008270	6/48	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8G1PXN	GO:0003676	4/48	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8G1PXN	GO:0016874	2/48	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8G7FD8	GO:0006351	23/90	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8G7FD8	GO:0005634	23/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8G7FD8	GO:0003700	23/90	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8G7FD8	GO:0043565	22/90	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8G7FD8	GO:0008301	1/90	DNA binding, bending	molecular_function	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]
EOG8G7FD8	GO:0031571	1/90	mitotic G1 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8G7FD8	GO:0035050	1/90	embryonic heart tube development	biological_process	"The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
EOG8G7FD8	GO:0007389	1/90	pattern specification process	biological_process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
EOG8G7FD8	GO:0000976	1/90	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8G7FD8	GO:0071456	1/90	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG8G7FD8	GO:0006909	1/90	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8G7FD8	GO:0051302	1/90	regulation of cell division	biological_process	"Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators]
EOG8G7FD8	GO:0009888	1/90	tissue development	biological_process	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]
EOG8SN45G	GO:0003682	14/229	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8SN45G	GO:0006915	3/229	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8SN45G	GO:0005634	3/229	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SN45G	GO:0003677	3/229	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8SN45G	GO:0008270	1/229	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84N171	GO:0004799	31/106	thymidylate synthase activity	molecular_function	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate." [EC:2.1.1.45, RHEA:12107]
EOG84N171	GO:0006231	31/106	dTMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732]
EOG84N171	GO:0022008	1/106	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84N171	GO:0006235	1/106	dTTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate." [ISBN:0198506732]
EOG8SN45J	GO:0005856	2/19	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8SN45J	GO:0005737	1/19	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SN45J	GO:0019898	1/19	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8G7FD5	GO:0016021	54/201	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G7FD5	GO:0005242	54/201	inward rectifier potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398]
EOG8G7FD5	GO:0004672	2/201	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8G7FD5	GO:0042391	2/201	regulation of membrane potential	biological_process	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
EOG8G7FD5	GO:0071805	2/201	potassium ion transmembrane transport	biological_process	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
EOG8G7FD5	GO:0035220	2/201	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8G7FD5	GO:0005524	2/201	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8G7FD5	GO:0006813	2/201	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8G7FD5	GO:0045475	1/201	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8G7FD5	GO:0048812	1/201	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8G7FD5	GO:0090099	1/201	negative regulation of decapentaplegic signaling pathway	biological_process	"Any process that decreases the frequency, rate, or extent of the decapentaplegic signaling pathway. The decapentaplegic signaling pathway is the series of molecular signals generated as a consequence of the signal decapentaplegic binding to one of its physiological receptors." [GOC:dph, GOC:tb]
EOG80P6NF	GO:0016021	97/327	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6NF	GO:0004995	41/327	tachykinin receptor activity	molecular_function	"Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:7639617, Wikipedia:Tachykinin]
EOG80P6NF	GO:0005886	40/327	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80P6NF	GO:0004983	35/327	neuropeptide Y receptor activity	molecular_function	"Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
EOG80P6NF	GO:0006935	33/327	chemotaxis	biological_process	"The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732]
EOG80P6NF	GO:0004950	33/327	chemokine receptor activity	molecular_function	"Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, http://en.wikipedia.org/wiki/Chemokine, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823]
EOG80P6NF	GO:0004930	13/327	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG80P6NF	GO:0050254	8/327	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG80P6NF	GO:0007186	3/327	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG80P6NF	GO:0008188	3/327	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG80P6NF	GO:0007218	3/327	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG80P6NF	GO:0007217	2/327	tachykinin receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor." [GOC:mah, PMID:14723970]
EOG80P6NF	GO:0005887	2/327	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6NF	GO:0050911	1/327	detection of chemical stimulus involved in sensory perception of smell	biological_process	"The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG80P6NF	GO:0050805	1/327	negative regulation of synaptic transmission	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
EOG80P6NF	GO:0042048	1/327	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG80P6NF	GO:0007166	1/327	cell surface receptor signaling pathway	biological_process	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
EOG80P6NF	GO:0004715	1/327	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG80P6NF	GO:0001653	1/327	peptide receptor activity	molecular_function	"Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl]
EOG80P6NF	GO:0002121	1/327	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8W3W32	GO:0005777	23/92	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG83JFKT	GO:0006139	19/56	nucleobase-containing compound metabolic process	biological_process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
EOG83JFKT	GO:0019205	19/56	nucleobase-containing compound kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]
EOG83JFKT	GO:0005524	19/56	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG83XXHD	GO:0005452	24/93	inorganic anion exchanger activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah]
EOG83XXHD	GO:0016021	24/93	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83XXHB	GO:0004222	43/148	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG83XXHB	GO:0008237	15/148	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG83XXHB	GO:0007229	1/148	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG8M0HHB	GO:0005524	28/92	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8M0HHB	GO:0019201	25/92	nucleotide kinase activity	molecular_function	"Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732]
EOG8M0HHB	GO:0016776	25/92	phosphotransferase activity, phosphate group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl]
EOG8M0HHB	GO:0004017	2/92	adenylate kinase activity	molecular_function	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]
EOG8M0HHB	GO:0009041	1/92	uridylate kinase activity	molecular_function	"Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators]
EOG8M0HHB	GO:0004127	1/92	cytidylate kinase activity	molecular_function	"Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.14]
EOG89KJ5Q	GO:0016020	4/89	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG89KJ5Q	GO:0016772	4/89	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG89KJ5Q	GO:0004168	3/89	dolichol kinase activity	molecular_function	"Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate." [EC:2.7.1.108]
EOG89KJ5Q	GO:0016021	2/89	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M0HHN	GO:0046872	23/140	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8M0HHN	GO:0005524	12/140	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8M0HHN	GO:0008094	12/140	DNA-dependent ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl]
EOG8M0HHN	GO:0003677	10/140	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8M0HHN	GO:0006259	10/140	DNA metabolic process	biological_process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]
EOG8M0HHN	GO:0003684	2/140	damaged DNA binding	molecular_function	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
EOG8M0HHN	GO:0006281	2/140	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG870WXQ	GO:0052655	26/94	L-valine transaminase activity	molecular_function	"Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN]
EOG870WXQ	GO:0052654	26/94	L-leucine transaminase activity	molecular_function	"Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN]
EOG870WXQ	GO:0052656	26/94	L-isoleucine transaminase activity	molecular_function	"Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN]
EOG870WXQ	GO:0009082	25/94	branched-chain amino acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [CHEBI:22918, GOC:ai]
EOG870WXQ	GO:0009081	1/94	branched-chain amino acid metabolic process	biological_process	"The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [CHEBI:22918, GOC:ai]
EOG870WXQ	GO:0016021	1/94	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89KJ5G	GO:0016021	22/76	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89KJ5G	GO:0016811	21/76	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]
EOG89KJ5G	GO:0006672	21/76	ceramide metabolic process	biological_process	"The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684]
EOG89KJ5G	GO:0017040	1/76	ceramidase activity	molecular_function	"Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23]
EOG89KJ5G	GO:0005783	1/76	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG89KJ5G	GO:0019216	1/76	regulation of lipid metabolic process	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
EOG89KJ5G	GO:0006665	1/76	sphingolipid metabolic process	biological_process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]
EOG89KJ5G	GO:0046514	1/76	ceramide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]
EOG89KJ5G	GO:0007420	1/76	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG870WXK	GO:0004197	1/57	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG870WXK	GO:0005515	1/57	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG870WXK	GO:0015459	1/57	potassium channel regulator activity	molecular_function	"Modulates the activity of a potassium channel." [GOC:mah]
EOG8JDKQV	GO:0005249	6/63	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8JDKQV	GO:0008076	6/63	voltage-gated potassium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
EOG8VDSDD	GO:0005634	3/82	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VDSDD	GO:0006355	2/82	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8VDSDD	GO:0006351	2/82	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8VDSDD	GO:0006357	1/82	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8VDSDD	GO:0046425	1/82	regulation of JAK-STAT cascade	biological_process	"Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf]
EOG8VDSDD	GO:0016592	1/82	mediator complex	cellular_component	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
EOG8VDSDD	GO:0005515	1/82	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VDSDD	GO:0001104	1/82	RNA polymerase II transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8VDSDD	GO:0006367	1/82	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG8GTNVM	GO:0016020	8/43	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8GTNVM	GO:0007264	8/43	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8GTNVM	GO:0005525	8/43	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8GTNVM	GO:0006184	8/43	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8GTNVM	GO:0004767	2/43	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG851H5H	GO:0008270	15/61	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZSCJ3	GO:0016021	3/26	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M0HH2	GO:0003676	7/156	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M0HH7	GO:0003677	18/140	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8M0HH7	GO:0015074	16/140	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8M0HH7	GO:0006310	16/140	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8M0HH7	GO:0008270	3/140	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8M0HH7	GO:0005634	2/140	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8M0HH7	GO:0003964	2/140	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8M0HH7	GO:0051607	2/140	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG8M0HH7	GO:0005739	2/140	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8M0HH7	GO:0004871	2/140	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8M0HH7	GO:0003723	2/140	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8M0HH7	GO:0005975	1/140	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8M0HH7	GO:0016616	1/140	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8M0HH7	GO:0003676	1/140	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M0HH4	GO:0030246	43/188	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG851H5W	GO:0003899	25/78	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG851H5W	GO:0003723	24/78	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG851H5W	GO:0006351	24/78	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG851H5W	GO:0000291	1/78	nuclear-transcribed mRNA catabolic process, exonucleolytic	biological_process	"The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc]
EOG851H5W	GO:0045948	1/78	positive regulation of translational initiation	biological_process	"Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG851H5W	GO:0006366	1/78	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG851H5W	GO:0003697	1/78	single-stranded DNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174]
EOG851H5W	GO:0003727	1/78	single-stranded RNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl]
EOG851H5W	GO:0006367	1/78	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG851H5W	GO:0060213	1/78	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	biological_process	"Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]
EOG851H5W	GO:0031369	1/78	translation initiation factor binding	molecular_function	"Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]
EOG851H5W	GO:0000932	1/78	cytoplasmic mRNA processing body	cellular_component	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603]
EOG851H5W	GO:0005665	1/78	DNA-directed RNA polymerase II, core complex	cellular_component	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG851H5W	GO:0005515	1/78	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8GTNVS	GO:0005509	17/50	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8GTNVS	GO:0005576	1/50	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8GTNVS	GO:0006749	1/50	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG8GTNVS	GO:0004364	1/50	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG83XXJQ	GO:0005525	25/88	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG83XXJQ	GO:0007264	25/88	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG83XXJQ	GO:0015031	25/88	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG83XXJQ	GO:0048803	1/88	imaginal disc-derived male genitalia morphogenesis	biological_process	"The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu]
EOG83XXJQ	GO:0005811	1/88	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG83XXJQ	GO:0007298	1/88	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG83XXJQ	GO:0016321	1/88	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG83XXJQ	GO:0006325	1/88	chromatin organization	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
EOG83XXJQ	GO:0008285	1/88	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG83XXJQ	GO:0048813	1/88	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG83XXJQ	GO:0003924	1/88	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG83XXJQ	GO:0016189	1/88	synaptic vesicle to endosome fusion	biological_process	"Fusion of a synaptic vesicle with the membrane of an endosome." [GOC:curators, PMID:10099709]
EOG83XXJQ	GO:0046664	1/88	dorsal closure, amnioserosa morphology change	biological_process	"The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138]
EOG83XXJQ	GO:0007349	1/88	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG83XXJQ	GO:0048227	1/88	plasma membrane to endosome transport	biological_process	"Transport of a vesicle from the plasma membrane to the endosome." [GOC:jid]
EOG83XXJQ	GO:0048477	1/88	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG83XXJQ	GO:0045202	1/88	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG83XXJQ	GO:0007067	1/88	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG83XXJQ	GO:0004767	1/88	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG83XXJQ	GO:0030100	1/88	regulation of endocytosis	biological_process	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]
EOG83XXJQ	GO:0005769	1/88	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG83XXJQ	GO:0007409	1/88	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG83XXJQ	GO:0035220	1/88	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG83XXJQ	GO:0007220	1/88	Notch receptor processing	biological_process	"The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]
EOG83XXJQ	GO:0035088	1/88	establishment or maintenance of apical/basal cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483]
EOG83XXJQ	GO:0034058	1/88	endosomal vesicle fusion	biological_process	"The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]
EOG83XXJQ	GO:0016348	1/88	imaginal disc-derived leg joint morphogenesis	biological_process	"The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG83XXJQ	GO:0005515	1/88	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG83XXJQ	GO:0006897	1/88	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG83XXJQ	GO:0043025	1/88	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG83XXJQ	GO:0048488	1/88	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG83XXJQ	GO:0050803	1/88	regulation of synapse structure or activity	biological_process	"Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]
EOG83XXJQ	GO:0006184	1/88	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8GTNVW	GO:0005615	233/444	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8GTNVW	GO:0010951	13/444	negative regulation of endopeptidase activity	biological_process	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0004867	13/444	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG8GTNVW	GO:0016740	13/444	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8GTNVW	GO:0030162	12/444	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8GTNVW	GO:0045861	10/444	negative regulation of proteolysis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
EOG8GTNVW	GO:0008233	8/444	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8GTNVW	GO:0032504	7/444	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8GTNVW	GO:0000155	6/444	phosphorelay sensor kinase activity	molecular_function	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
EOG8GTNVW	GO:0016020	6/444	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8GTNVW	GO:0019732	1/444	antifungal humoral response	biological_process	"An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8GTNVW	GO:0008063	1/444	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8GTNVW	GO:0002784	1/444	regulation of antimicrobial peptide production	biological_process	"Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
EOG8GTNVW	GO:0003677	1/444	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GTNVW	GO:0005576	1/444	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8GTNVW	GO:0006281	1/444	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8GTNVW	GO:0050829	1/444	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GTNVW	GO:0060570	1/444	negative regulation of peptide hormone processing	biological_process	"Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0006955	1/444	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8GTNVW	GO:0004869	1/444	cysteine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0010955	1/444	negative regulation of protein processing	biological_process	"Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]
EOG8GTNVW	GO:0042562	1/444	hormone binding	molecular_function	"Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
EOG8GTNVW	GO:0045751	1/444	negative regulation of Toll signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8GTNVW	GO:0050832	1/444	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8Z38X5	GO:0005549	5/46	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG83JFK9	GO:0006544	28/99	glycine metabolic process	biological_process	"The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators]
EOG83JFK9	GO:0006563	28/99	L-serine metabolic process	biological_process	"The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg]
EOG83JFK9	GO:0030170	28/99	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG83JFK9	GO:0004372	28/99	glycine hydroxymethyltransferase activity	molecular_function	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1]
EOG83JFK9	GO:0035999	25/99	tetrahydrofolate interconversion	biological_process	"The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999, UniPathway:UPA00193]
EOG83JFK9	GO:0008168	7/99	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG83JFK9	GO:0048149	1/99	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG837TVT	GO:0003676	21/93	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG837TVT	GO:0071011	1/93	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG837TVT	GO:0000398	1/93	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG837TVT	GO:0005634	1/93	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG837TVT	GO:0030529	1/93	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG837TVT	GO:0019013	1/93	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG83JFK7	GO:0008589	1/92	regulation of smoothened signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG83JFK7	GO:0008039	1/92	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG83JFK7	GO:0007224	1/92	smoothened signaling pathway	biological_process	"A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
EOG83JFK7	GO:0005515	1/92	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG83JFK7	GO:0005578	1/92	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG83JFK7	GO:0005576	1/92	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG83JFK7	GO:0045880	1/92	positive regulation of smoothened signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG83JFK7	GO:0050821	1/92	protein stabilization	biological_process	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]
EOG83XXH8	GO:0017112	1/79	Rab guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG83XXH8	GO:0032313	1/79	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG83XXH8	GO:0035011	1/79	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG83XXH8	GO:0032483	1/79	regulation of Rab protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]
EOG8FBM93	GO:0046331	1/118	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8FBM94	GO:0016597	11/116	amino acid binding	molecular_function	"Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]
EOG8FBM94	GO:0008152	8/116	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8FBM94	GO:0004794	6/116	L-threonine ammonia-lyase activity	molecular_function	"Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [EC:4.3.1.19]
EOG8FBM94	GO:0006567	4/116	threonine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
EOG8FBM94	GO:0003824	1/116	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8FBM95	GO:0003777	1/86	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8FBM95	GO:0007018	1/86	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8FBM95	GO:0030286	1/86	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8VQD49	GO:0005506	28/85	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8VQD49	GO:0051536	27/85	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8VQD49	GO:0016226	27/85	iron-sulfur cluster assembly	biological_process	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]
EOG8VQD49	GO:0005737	14/85	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8VQD49	GO:0005739	13/85	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8VQD49	GO:0008026	8/85	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8VQD49	GO:0005524	8/85	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VQD49	GO:0003676	8/85	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8616M6	GO:0008270	4/65	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8616M6	GO:0003676	3/65	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8616M6	GO:0003723	1/65	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8616M6	GO:0003964	1/65	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8VQD44	GO:0020037	27/145	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8VQD44	GO:0005506	27/145	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8VQD44	GO:0016705	25/145	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8VQD44	GO:0051205	23/145	protein insertion into membrane	biological_process	"The process that results in the incorporation of a protein into a biological membrane.  Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]
EOG8VQD44	GO:0016021	23/145	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VQD44	GO:0004497	22/145	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8VQD44	GO:0005576	2/145	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8VQD44	GO:0008061	2/145	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8VQD44	GO:0006030	2/145	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8VQD44	GO:0008386	2/145	cholesterol monooxygenase (side-chain-cleaving) activity	molecular_function	"Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6]
EOG8VQD44	GO:0005272	1/145	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8VQD44	GO:0042768	1/145	ecdysteroid 2-hydroxylase activity	molecular_function	"Catalysis of the hydroxylation of an ecdysteroid at carbon position 2." [PMID:12177427]
EOG8VQD44	GO:0031966	1/145	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG8VQD44	GO:0007391	1/145	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8VQD44	GO:0007417	1/145	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8VQD44	GO:0008045	1/145	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8VQD44	GO:0006697	1/145	ecdysone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732]
EOG8VQD44	GO:0007494	1/145	midgut development	biological_process	"The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
EOG8VQD44	GO:0008258	1/145	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8VQD44	GO:0005739	1/145	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG87M4DC	GO:0016787	24/73	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG87M4DC	GO:0051726	1/73	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8TQPQV	GO:0016021	21/79	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG886BTX	GO:0016905	1/151	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG886BTX	GO:0004550	1/151	nucleoside diphosphate kinase activity	molecular_function	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]
EOG886BTX	GO:0006241	1/151	CTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]
EOG886BTX	GO:0006228	1/151	UTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732]
EOG886BTX	GO:0006183	1/151	GTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG886BTX	GO:0005524	1/151	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG886BTX	GO:0010506	1/151	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG89360G	GO:0003676	70/406	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89360G	GO:0005634	11/406	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG89360G	GO:0003700	9/406	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG89360G	GO:0003707	9/406	steroid hormone receptor activity	molecular_function	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
EOG89360G	GO:0006351	8/406	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG89360G	GO:0046872	3/406	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89360G	GO:0003964	2/406	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG89360G	GO:0003723	2/406	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG89360G	GO:0005506	1/406	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG89360G	GO:0042981	1/406	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG89360G	GO:0003677	1/406	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG89360G	GO:0008270	1/406	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG89360G	GO:0019058	1/406	viral life cycle	biological_process	"A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]
EOG89360G	GO:0005622	1/406	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG89360G	GO:0006886	1/406	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8B5RMS	GO:0006629	30/110	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8B5RMS	GO:0005576	30/110	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8B5RMS	GO:0016787	25/110	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8B5RMS	GO:0003824	4/110	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8B5RMS	GO:0006909	1/110	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8B5RMS	GO:0016491	1/110	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8B5RMS	GO:0004806	1/110	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG883GJZ	GO:0016021	1/188	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG883GJZ	GO:0006909	1/188	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG83V28K	GO:0022008	1/89	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG83V28K	GO:0005634	1/89	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG89360P	GO:0016021	60/147	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PVRD3	GO:0097056	22/75	selenocysteinyl-tRNA(Sec) biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA[Ser]Sec kinase; lastly, selenium is swapped for the phosphate on the serine." [CHEBI:13166, GOC:yaf, PMID:15317934, UniPathway:UPA00906]
EOG8PVRD3	GO:0016785	22/75	transferase activity, transferring selenium-containing groups	molecular_function	"Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8PVRD3	GO:0030170	21/75	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8PVRD3	GO:0016012	1/75	sarcoglycan complex	cellular_component	"A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609]
EOG8XD66F	GO:0009396	56/195	folic acid-containing compound biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai]
EOG8XD66F	GO:0004488	51/195	methylenetetrahydrofolate dehydrogenase (NADP+) activity	molecular_function	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH." [EC:1.5.1.5, RHEA:22815]
EOG8XD66F	GO:0005524	28/195	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8XD66F	GO:0004329	28/195	formate-tetrahydrofolate ligase activity	molecular_function	"Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [EC:6.3.4.3]
EOG8XD66F	GO:0004477	3/195	methenyltetrahydrofolate cyclohydrolase activity	molecular_function	"Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate." [EC:3.5.4.9]
EOG8XD66F	GO:0000287	2/195	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8XD66F	GO:0006730	2/195	one-carbon metabolic process	biological_process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
EOG8XD66F	GO:0004487	2/195	methylenetetrahydrofolate dehydrogenase (NAD+) activity	molecular_function	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH." [EC:1.5.1.15, RHEA:22895]
EOG8XD66F	GO:0046653	1/195	tetrahydrofolate metabolic process	biological_process	"The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]
EOG8XD66F	GO:0006164	1/195	purine nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
EOG8XD66F	GO:0009086	1/195	methionine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
EOG8XD66F	GO:0000105	1/195	histidine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]
EOG8XD66F	GO:0008652	1/195	cellular amino acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732]
EOG8XD66F	GO:0005739	1/195	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8XD66F	GO:0016746	1/195	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8XD66F	GO:0035999	1/195	tetrahydrofolate interconversion	biological_process	"The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999, UniPathway:UPA00193]
EOG8XD66F	GO:0005829	1/195	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8XD66F	GO:0019509	1/195	L-methionine biosynthetic process from methylthioadenosine	biological_process	"The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361]
EOG8XD66F	GO:0005737	1/195	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XD66F	GO:0042301	1/195	phosphate ion binding	molecular_function	"Interacting selectively and non-covalently with phosphate." [GOC:jl]
EOG8XD66F	GO:0005811	1/195	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8XD66F	GO:0043874	1/195	acireductone synthase activity	molecular_function	"Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate." [EC:3.1.3.77]
EOG8F4VV2	GO:0005737	1/27	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8F4VV2	GO:0018149	1/27	peptide cross-linking	biological_process	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]
EOG893605	GO:0006355	25/99	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG893605	GO:0006289	25/99	nucleotide-excision repair	biological_process	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]
EOG893605	GO:0000439	25/99	core TFIIH complex	cellular_component	"The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015]
EOG893605	GO:0006366	1/99	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG893605	GO:0009411	1/99	response to UV	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]
EOG893605	GO:0005634	1/99	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG893605	GO:0001113	1/99	transcriptional open complex formation at RNA polymerase II promoter	biological_process	"Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161]
EOG893605	GO:0005675	1/99	holo TFIIH complex	cellular_component	"A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of  the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]
EOG893605	GO:0006367	1/99	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG893605	GO:0001111	1/99	promoter clearance from RNA polymerase II promoter	biological_process	"Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047]
EOG893605	GO:0003743	1/99	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG87SVVM	GO:0005524	25/86	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87SVVM	GO:0017111	25/86	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG87SVVM	GO:0000808	24/86	origin recognition complex	cellular_component	"A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh]
EOG87SVVM	GO:0005634	24/86	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87SVVM	GO:0006260	24/86	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG87SVVM	GO:0003682	16/86	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG87SVVM	GO:0022008	1/86	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG87SVVM	GO:0006277	1/86	DNA amplification	biological_process	"The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment." [ISBN:0721601464]
EOG87SVVM	GO:0003677	1/86	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG87SVVM	GO:0006270	1/86	DNA replication initiation	biological_process	"The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194]
EOG87SVVM	GO:0008283	1/86	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG87SVVM	GO:0005664	1/86	nuclear origin of replication recognition complex	cellular_component	"A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh]
EOG8M3CR2	GO:0051726	1/67	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8M3CR2	GO:0051349	1/67	positive regulation of lyase activity	biological_process	"Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai]
EOG8K0T3J	GO:0005198	24/92	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8K0T3J	GO:0006890	24/92	retrograde vesicle-mediated transport, Golgi to ER	biological_process	"The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524]
EOG8K0T3J	GO:0005875	1/92	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8K0T3J	GO:0030126	1/92	COPI vesicle coat	cellular_component	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]
EOG8K0T3J	GO:0019028	1/92	viral capsid	cellular_component	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
EOG8VQD4V	GO:0016020	23/77	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8VQD4V	GO:0048812	1/77	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8VQD4V	GO:0005764	1/77	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8VQD4F	GO:0004017	27/86	adenylate kinase activity	molecular_function	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]
EOG8VQD4F	GO:0005524	27/86	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VQD4F	GO:0006172	26/86	ADP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate." [GOC:ai]
EOG8VQD4F	GO:0005829	15/86	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8VQD4F	GO:0005758	15/86	mitochondrial intermembrane space	cellular_component	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]
EOG8VQD4F	GO:0005739	12/86	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8VQD4F	GO:0046899	2/86	nucleoside triphosphate adenylate kinase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP." [EC:2.7.4.10]
EOG8VQD4F	GO:0022008	1/86	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8VQD4F	GO:0005811	1/86	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8VQD4F	GO:0046939	1/86	nucleotide phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]
EOG87M4D4	GO:0007067	3/39	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG87M4D4	GO:0000775	3/39	chromosome, centromeric region	cellular_component	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
EOG87M4D5	GO:0000502	6/113	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG87M4D5	GO:0043248	1/113	proteasome assembly	biological_process	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]
EOG87M4D5	GO:0032436	1/113	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	biological_process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]
EOG87M4D5	GO:0005737	1/113	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87M4D5	GO:0008584	1/113	male gonad development	biological_process	"The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure." [GOC:jid]
EOG87M4D5	GO:0005515	1/113	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG87M4D5	GO:0070864	1/113	sperm individualization complex	cellular_component	"A macromolecular complex that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst." [GOC:sart, PMID:10588662, PMID:9550716]
EOG87M4D5	GO:0007140	1/113	male meiosis	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
EOG87M4D5	GO:0006974	1/113	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8HMMR1	GO:0016021	5/39	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HMMR1	GO:0004930	4/39	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8323DN	GO:0016021	2/83	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8323DN	GO:0004563	1/83	beta-N-acetylhexosaminidase activity	molecular_function	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]
EOG8QNQ95	GO:0004672	5/42	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8QNQ95	GO:0033867	1/42	Fas-activated serine/threonine kinase activity	molecular_function	"Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein." [EC:2.7.11.8]
EOG8H1DBH	GO:0006511	68/146	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8H1DBH	GO:0016301	5/146	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8H1DBH	GO:0022008	2/146	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8H1DBH	GO:0005515	2/146	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8H1DBH	GO:0016874	2/146	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8H1DBH	GO:0046627	1/146	negative regulation of insulin receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8H1DBH	GO:0007095	1/146	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8H1DBH	GO:0004842	1/146	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8H1DBH	GO:0016322	1/146	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG8H1DBH	GO:0051298	1/146	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8H1DBH	GO:0010824	1/146	regulation of centrosome duplication	biological_process	"Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]
EOG8H1DBH	GO:0005875	1/146	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8H1DBH	GO:0030261	1/146	chromosome condensation	biological_process	"The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8H1DBH	GO:0042023	1/146	DNA endoreduplication	biological_process	"Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw]
EOG8H1DBH	GO:0005813	1/146	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8H1DBH	GO:0031647	1/146	regulation of protein stability	biological_process	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]
EOG8H1DBH	GO:0045931	1/146	positive regulation of mitotic cell cycle	biological_process	"Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8H1DBH	GO:0007067	1/146	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8H1DBH	GO:0019005	1/146	SCF ubiquitin ligase complex	cellular_component	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
EOG8H1DBH	GO:0005819	1/146	spindle	cellular_component	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
EOG8ZCWKM	GO:0005768	1/122	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG8ZCWKM	GO:0051020	1/122	GTPase binding	molecular_function	"Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]
EOG8ZCWKM	GO:0005737	1/122	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZCWKM	GO:0005667	1/122	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8ZCWKM	GO:0048471	1/122	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8ZCWKM	GO:0005515	1/122	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8ZCWKM	GO:0005634	1/122	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZCWKM	GO:0035210	1/122	prepupal development	biological_process	"The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects that undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation." [GOC:mtg_sensu, http://sdb.bio.purdue.edu/fly/aimain/1adult.htm]
EOG8ZCWKM	GO:0001578	1/122	microtubule bundle formation	biological_process	"A process that results in a parallel arrangement of microtubules." [GOC:dph]
EOG8ZCWKM	GO:0034314	1/122	Arp2/3 complex-mediated actin nucleation	biological_process	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]
EOG8ZCWKM	GO:0051017	1/122	actin filament bundle assembly	biological_process	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
EOG8ZCWKM	GO:0035277	1/122	spiracle morphogenesis, open tracheal system	biological_process	"The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268]
EOG8ZCWKM	GO:0048477	1/122	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8ZCWKM	GO:0051764	1/122	actin crosslink formation	biological_process	"The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes." [GOC:ai]
EOG8323DZ	GO:0022008	1/105	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8323DZ	GO:0009306	1/105	protein secretion	biological_process	"The controlled release of proteins from a cell." [GOC:ai]
EOG8323DZ	GO:0005789	1/105	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8323DZ	GO:0006890	1/105	retrograde vesicle-mediated transport, Golgi to ER	biological_process	"The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524]
EOG8323DZ	GO:0005783	1/105	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8323DZ	GO:0005484	1/105	SNAP receptor activity	molecular_function	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
EOG8323DZ	GO:0007030	1/105	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8323DZ	GO:0016021	1/105	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CC6GT	GO:0008242	10/51	omega peptidase activity	molecular_function	"Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-]
EOG8CC6GT	GO:0003676	1/51	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CC6GT	GO:0008270	1/51	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RNDPW	GO:0004749	25/85	ribose phosphate diphosphokinase activity	molecular_function	"Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+)." [EC:2.7.6.1, RHEA:15612]
EOG8RNDPW	GO:0009165	25/85	nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]
EOG8RNDPW	GO:0000287	25/85	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8RNDPW	GO:0016301	4/85	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8N332X	GO:0000398	26/107	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8N332X	GO:0046540	26/107	U4/U6 x U5 tri-snRNP complex	cellular_component	"A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins." [GOC:krc, GOC:pr, PMID:11867543]
EOG8N332X	GO:0019013	3/107	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8N332X	GO:0030532	1/107	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8N332X	GO:0005634	1/107	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8N332X	GO:0005681	1/107	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8N332X	GO:0071011	1/107	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8N332X	GO:0031935	1/107	regulation of chromatin silencing	biological_process	"Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah]
EOG82FW0K	GO:0016740	9/186	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG82FW0K	GO:0004364	2/186	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG82FW0K	GO:0005811	1/186	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG82FW0K	GO:0050220	1/186	prostaglandin-E synthase activity	molecular_function	"Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)." [EC:5.3.99.3, RHEA:12896]
EOG8RNDPF	GO:0005634	1/99	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RNDPF	GO:0005720	1/99	nuclear heterochromatin	cellular_component	"A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732]
EOG8KM1JB	GO:0048488	26/87	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8KM1JB	GO:0005262	26/87	calcium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8KM1JB	GO:0030285	26/87	integral component of synaptic vesicle membrane	cellular_component	"The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KM1JB	GO:0046530	11/87	photoreceptor cell differentiation	biological_process	"The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732]
EOG8KM1JB	GO:0030054	11/87	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8KM1JB	GO:0044214	1/87	spanning component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:ecd]
EOG8KM1JB	GO:0042802	1/87	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG8KM1JB	GO:0042981	1/87	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8KM1JB	GO:0016021	1/87	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PK4QS	GO:0008270	1/72	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KM1J7	GO:0030414	16/65	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8KM1J7	GO:0008233	1/65	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8KM1J1	GO:0016651	1/89	oxidoreductase activity, acting on NAD(P)H	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8KM1J1	GO:0005737	1/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8KM1J1	GO:0005739	1/89	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8KM1J1	GO:0005634	1/89	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8KM1J1	GO:0005515	1/89	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KM1J1	GO:0051341	1/89	regulation of oxidoreductase activity	biological_process	"Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-, GOC:ai]
EOG8KM1J1	GO:0055114	1/89	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8KM1J1	GO:0045087	1/89	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8RNDP9	GO:0007076	28/105	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8RNDP9	GO:0000796	28/105	condensin complex	cellular_component	"A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
EOG8RNDP9	GO:0005524	24/105	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8RNDP9	GO:0006310	21/105	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8RNDP9	GO:0006281	21/105	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8RNDP9	GO:0005634	19/105	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RNDP9	GO:0016491	1/105	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8RNDP9	GO:0022008	1/105	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8RNDP9	GO:0000785	1/105	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG8RNDP9	GO:0007067	1/105	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8RNDP9	GO:0005875	1/105	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8RNDP9	GO:0007052	1/105	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8RNDP9	GO:0005737	1/105	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8W6R92	GO:0003684	19/72	damaged DNA binding	molecular_function	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
EOG8W6R92	GO:0003887	19/72	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8W6R92	GO:0006281	18/72	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8W6R92	GO:0019985	1/72	translesion synthesis	biological_process	"The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, PMID:10535901]
EOG8W6R92	GO:0006261	1/72	DNA-dependent DNA replication	biological_process	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]
EOG8M947F	GO:0005975	32/195	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8M947F	GO:0004553	32/195	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8M947F	GO:0045088	1/195	regulation of innate immune response	biological_process	"Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8M947F	GO:0032491	1/195	detection of molecule of fungal origin	biological_process	"The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal." [GOC:mah, GOC:rl]
EOG8M947F	GO:0009986	1/195	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8M947F	GO:0002758	1/195	innate immune response-activating signal transduction	biological_process	"The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8M947F	GO:0045087	1/195	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8M947F	GO:0002221	1/195	pattern recognition receptor signaling pathway	biological_process	"Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
EOG8M947F	GO:0051607	1/195	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG8M947F	GO:0008329	1/195	signaling pattern recognition receptor activity	molecular_function	"Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity." [GOC:ar, PMID:12507420, PMID:12925128, PMID:14523544, Wikipedia:Pattern_recognition_receptor]
EOG8M947F	GO:0001872	1/195	(1->3)-beta-D-glucan binding	molecular_function	"Interacting selectively and non-covalently with (1->3)-beta-D-glucans." [PMID:14707091]
EOG8M947F	GO:0009620	1/195	response to fungus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
EOG8M947F	GO:0005576	1/195	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8PK4Q1	GO:0003676	4/37	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8PK4Q1	GO:0008270	4/37	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PK4Q1	GO:0005634	4/37	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PK4Q1	GO:0046872	1/37	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80GG4P	GO:0005234	33/99	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG80GG4P	GO:0004970	32/99	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG80GG4P	GO:0016021	31/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80GG4P	GO:0030054	26/99	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG80GG4P	GO:0045211	26/99	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG80GG4P	GO:0016020	2/99	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG80GG4P	GO:0072375	1/99	medium-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster)." [GOC:sart, PMID:14659098, PMID:7923375]
EOG80GG4P	GO:0007616	1/99	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG80GG4P	GO:0035249	1/99	synaptic transmission, glutamatergic	biological_process	"The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv]
EOG80GG4P	GO:0004972	1/99	NMDA glutamate receptor activity	molecular_function	"An ionotropic glutamate receptor activity that exhibits slow gating by glutamate, acts by opening a nonselective cation channel, and can be activated by L-aspartate." [GOC:mah, PMID:10049997]
EOG80GG4P	GO:0003723	1/99	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG80GG4P	GO:0017146	1/99	NMDA selective glutamate receptor complex	cellular_component	"An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
EOG80GG4P	GO:0003964	1/99	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG80GG4P	GO:0008328	1/99	ionotropic glutamate receptor complex	cellular_component	"A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
EOG80GG4P	GO:0050975	1/99	sensory perception of touch	biological_process	"The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]
EOG80GG4P	GO:0034220	1/99	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG80GG4P	GO:0030425	1/99	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG80GG4P	GO:0035235	1/99	ionotropic glutamate receptor signaling pathway	biological_process	"A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732]
EOG8WDGSR	GO:0005622	7/98	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8WDGSR	GO:0005215	7/98	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8WDGSR	GO:0005501	1/98	retinoid binding	molecular_function	"Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732]
EOG8WDGSR	GO:0007602	1/98	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG8WDGSR	GO:0016063	1/98	rhodopsin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
EOG83R61D	GO:0016021	17/75	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83R61D	GO:0007015	1/75	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG83R61D	GO:0015629	1/75	actin cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
EOG83R61D	GO:0008335	1/75	female germline ring canal stabilization	biological_process	"Maintenance of the structural integrity of the ring canals connecting the female germline cyst." [GOC:curators]
EOG83R61D	GO:0005635	1/75	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG83R61D	GO:0040011	1/75	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG83R61D	GO:0060361	1/75	flight	biological_process	"Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph]
EOG83R61D	GO:0051640	1/75	organelle localization	biological_process	"Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]
EOG83R61D	GO:0016477	1/75	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG83R61D	GO:0007498	1/75	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG83R61D	GO:0007303	1/75	cytoplasmic transport, nurse cell to oocyte	biological_process	"The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238]
EOG83R61D	GO:0040023	1/75	establishment of nucleus localization	biological_process	"The directed movement of the nucleus to a specific location within a cell." [GOC:ai]
EOG83R61D	GO:0031965	1/75	nuclear membrane	cellular_component	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
EOG83R61D	GO:0008092	1/75	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG83R61D	GO:0007519	1/75	skeletal muscle tissue development	biological_process	"The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
EOG83R61D	GO:0003779	1/75	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG83R61D	GO:0007523	1/75	larval visceral muscle development	biological_process	"The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid]
EOG83R61D	GO:0030018	1/75	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG83R61D	GO:0048471	1/75	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG83R61D	GO:0005737	1/75	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZCWK4	GO:0016491	23/90	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8ZCWK4	GO:0047061	1/90	glucose-fructose oxidoreductase activity	molecular_function	"Catalysis of the reaction: D-fructose + D-glucose = D-glucitol + D-glucono-1,5-lactone." [EC:1.1.99.28, RHEA:20640]
EOG8QNQ9T	GO:0005524	53/164	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QNQ9T	GO:0004674	24/164	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8QNQ9T	GO:0005978	24/164	glycogen biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]
EOG8QNQ9T	GO:0005964	24/164	phosphorylase kinase complex	cellular_component	"An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a." [EC:2.7.11.19]
EOG8QNQ9T	GO:0004689	24/164	phosphorylase kinase activity	molecular_function	"Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a." [EC:2.7.11.19]
EOG8QNQ9T	GO:0004672	4/164	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8QNQ9T	GO:0008353	3/164	RNA polymerase II carboxy-terminal domain kinase activity	molecular_function	"Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah]
EOG8QNQ9T	GO:0006468	2/164	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8QNQ9T	GO:0007067	1/164	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8QNQ9T	GO:0032806	1/164	carboxy-terminal domain protein kinase complex	cellular_component	"A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683]
EOG8QNQ9T	GO:0006366	1/164	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8QNQ9T	GO:0004693	1/164	cyclin-dependent protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]
EOG8QNQ9T	GO:0006007	1/164	glucose catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai]
EOG8QNQ9T	GO:0012501	1/164	programmed cell death	biological_process	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]
EOG8QNQ9T	GO:2001141	1/164	regulation of RNA biosynthetic process	biological_process	"Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph]
EOG8QNQ9T	GO:0006367	1/164	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG8QNQ9T	GO:0001111	1/164	promoter clearance from RNA polymerase II promoter	biological_process	"Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047]
EOG8QNQ9T	GO:0005634	1/164	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8QNQ9T	GO:0048598	1/164	embryonic morphogenesis	biological_process	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]
EOG8QNQ9T	GO:0000079	1/164	regulation of cyclin-dependent protein serine/threonine kinase activity	biological_process	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]
EOG8QNQ9T	GO:0005737	1/164	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8QNQ9T	GO:0005675	1/164	holo TFIIH complex	cellular_component	"A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of  the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]
EOG8CC6G3	GO:0005975	65/184	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8CC6G3	GO:0004553	59/184	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8CC6G3	GO:0008456	6/184	alpha-N-acetylgalactosaminidase activity	molecular_function	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides." [EC:3.2.1.49]
EOG8CC6G3	GO:0016139	2/184	glycoside catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]
EOG8CC6G3	GO:0009311	2/184	oligosaccharide metabolic process	biological_process	"The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]
EOG8CC6G3	GO:0005737	2/184	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CC6G3	GO:0046477	2/184	glycosylceramide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai]
EOG8CC6G3	GO:0004557	2/184	alpha-galactosidase activity	molecular_function	"Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase." [EC:3.2.1.22]
EOG8CC6G3	GO:0052692	1/184	raffinose alpha-galactosidase activity	molecular_function	"Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose." [MetaCyc:RXN-11502]
EOG8MWBMX	GO:0005622	143/592	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8MWBMX	GO:0005215	143/592	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8MWBMX	GO:0022008	1/592	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8MWBMX	GO:0016787	1/592	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8N06WZ	GO:0016998	21/74	cell wall macromolecule catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators]
EOG88GZJM	GO:0015074	16/52	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG88GZJM	GO:0003676	16/52	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88GZJM	GO:0005634	2/52	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GMXC8	GO:0008168	23/79	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8GMXC8	GO:0042742	1/79	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8GMXC8	GO:0019843	1/79	rRNA binding	molecular_function	"Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl]
EOG8GMXC8	GO:0005730	1/79	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8GMXC8	GO:0022008	1/79	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8GMXC8	GO:0031167	1/79	rRNA methylation	biological_process	"The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah]
EOG8GMXC8	GO:0070037	1/79	rRNA (pseudouridine) methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule." [GOC:imk, GOC:mah]
EOG8909Q4	GO:0005089	2/26	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8909Q3	GO:0004984	23/76	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8909Q3	GO:0005549	23/76	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8909Q3	GO:0004930	18/76	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8909Q3	GO:0016021	18/76	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8909Q3	GO:0005886	12/76	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8909Q3	GO:0016020	5/76	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8N06WF	GO:0008430	23/64	selenium binding	molecular_function	"Interacting selectively and non-covalently with selenium (Se)." [GOC:ai]
EOG8N06WF	GO:0045454	23/64	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8DRCV3	GO:0003676	3/252	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DRCV3	GO:0015074	3/252	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8DRCV3	GO:0003723	2/252	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8DRCV3	GO:0008270	2/252	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DRCV3	GO:0003964	2/252	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8DRCV3	GO:0004190	1/252	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG85QKVN	GO:0003700	23/93	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG85QKVN	GO:0043565	22/93	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG85QKVN	GO:0005991	1/93	trehalose metabolic process	biological_process	"The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]
EOG85QKVN	GO:0035074	1/93	pupation	biological_process	"The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238]
EOG85QKVN	GO:0042594	1/93	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG85QKVN	GO:0000980	1/93	RNA polymerase II distal enhancer sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH]
EOG85QKVN	GO:0035073	1/93	pupariation	biological_process	"The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
EOG85QKVN	GO:0006355	1/93	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85QKVN	GO:0007591	1/93	molting cycle, chitin-based cuticle	biological_process	"The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu]
EOG85QKVN	GO:0001105	1/93	RNA polymerase II transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG85QKVN	GO:0006641	1/93	triglyceride metabolic process	biological_process	"The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732]
EOG85QKVN	GO:0001102	1/93	RNA polymerase II activating transcription factor binding	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription." [GOC:txnOH]
EOG85QKVN	GO:0007552	1/93	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG85QKVN	GO:0046982	1/93	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG85QKVN	GO:0045944	1/93	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8KPWR7	GO:0005524	26/100	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KPWR7	GO:0004674	25/100	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8KPWR7	GO:0007165	16/100	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8KPWR7	GO:0005840	3/100	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8KPWR7	GO:0040018	1/100	positive regulation of multicellular organism growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8KPWR7	GO:0007584	1/100	response to nutrient	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators]
EOG8KPWR7	GO:0005874	1/100	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8KPWR7	GO:0006974	1/100	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8KPWR7	GO:0045927	1/100	positive regulation of growth	biological_process	"Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
EOG8KPWR7	GO:0005829	1/100	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8KPWR7	GO:0051124	1/100	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8KPWR7	GO:0008361	1/100	regulation of cell size	biological_process	"Any process that modulates the size of a cell." [GOC:go_curators]
EOG8KPWR7	GO:0048786	1/100	presynaptic active zone	cellular_component	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
EOG8KPWR7	GO:0046622	1/100	positive regulation of organ growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
EOG8KPWR7	GO:0016239	1/100	positive regulation of macroautophagy	biological_process	"Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464]
EOG8KPWR7	GO:0008340	1/100	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8KPWR7	GO:0004711	1/100	ribosomal protein S6 kinase activity	molecular_function	"Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608]
EOG8KPWR7	GO:0005515	1/100	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KPWR7	GO:0030307	1/100	positive regulation of cell growth	biological_process	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8KPWR7	GO:0030536	1/100	larval feeding behavior	biological_process	"Feeding behavior in a larval (immature) organism." [GOC:mah]
EOG8KPWR7	GO:0006468	1/100	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8KPWR7	GO:0000226	1/100	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8KPWR7	GO:0045793	1/100	positive regulation of cell size	biological_process	"Any process that increases cell size." [GOC:go_curators]
EOG8KPWR7	GO:0007411	1/100	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8KPWR7	GO:0040007	1/100	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG8KPWR7	GO:0010508	1/100	positive regulation of autophagy	biological_process	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8KPWR7	GO:0048477	1/100	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8KPWR7	GO:0007015	1/100	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8KPWR7	GO:0004697	1/100	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG8KPWR7	GO:0006909	1/100	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8KPWR7	GO:2001023	1/100	regulation of response to drug	biological_process	"Any process that modulates the frequency, rate or extent of response to drug." [GOC:obol]
EOG8KPWR7	GO:0048813	1/100	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG85QKVG	GO:0005840	31/100	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG85QKVG	GO:0003735	31/100	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG85QKVG	GO:0006412	31/100	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG85QKVG	GO:0007052	1/100	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG85QKVG	GO:0051298	1/100	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG85QKVG	GO:0000022	1/100	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG85QKVG	GO:0051297	1/100	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG883GMP	GO:0016272	25/84	prefoldin complex	cellular_component	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]
EOG883GMP	GO:0006457	25/84	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8SN42X	GO:0003824	27/204	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8SN42X	GO:0004802	3/204	transketolase activity	molecular_function	"Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [EC:2.2.1.1, GOC:fmc]
EOG8SN42X	GO:0005875	2/204	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8SN42X	GO:0031122	2/204	cytoplasmic microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
EOG8SN42X	GO:0090063	1/204	positive regulation of microtubule nucleation	biological_process	"Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
EOG8SN42X	GO:0000922	1/204	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8SN42X	GO:0005515	1/204	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8SN42X	GO:0005813	1/204	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8SN42X	GO:0007067	1/204	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8SN42X	GO:0007029	1/204	endoplasmic reticulum organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
EOG8SN42X	GO:0008017	1/204	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8SN42X	GO:0007143	1/204	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8SN42X	GO:0048477	1/204	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8SN42X	GO:0035371	1/204	microtubule plus-end	cellular_component	"The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]
EOG8SN42X	GO:0045450	1/204	bicoid mRNA localization	biological_process	"Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators]
EOG8SN42X	GO:0031935	1/204	regulation of chromatin silencing	biological_process	"Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah]
EOG8SN42X	GO:0007344	1/204	pronuclear fusion	biological_process	"The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X]
EOG8SN42X	GO:0016325	1/204	oocyte microtubule cytoskeleton organization	biological_process	"Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]
EOG8SN42X	GO:0005811	1/204	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8SN42X	GO:0007017	1/204	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8SN42X	GO:0000022	1/204	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8SN42X	GO:0007411	1/204	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8SN42X	GO:0015631	1/204	tubulin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]
EOG85QKVQ	GO:0046872	25/88	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85QKVQ	GO:0003677	19/88	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG85QKVQ	GO:0048813	1/88	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8KPWRP	GO:0055085	23/91	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8KPWRP	GO:0016021	23/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KPWRP	GO:0005215	16/91	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8KPWRP	GO:0005886	1/91	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8KPWRP	GO:0048477	1/91	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8KPWRV	GO:0030968	1/84	endoplasmic reticulum unfolded protein response	biological_process	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]
EOG8KPWRV	GO:0005875	1/84	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8V720G	GO:0003735	20/65	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8V720G	GO:0005840	20/65	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8V720G	GO:0006412	20/65	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8V720G	GO:0007052	1/65	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8V720G	GO:0000022	1/65	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG85QKV7	GO:0030246	32/98	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG85QKV7	GO:0046872	1/98	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85QKV7	GO:0008039	1/98	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG85QKV7	GO:0016936	1/98	galactoside binding	molecular_function	"Interacting selectively and non-covalently with any glycoside in which the sugar group is galactose." [CHEBI:24163, GOC:jl, ISBN:0198506732]
EOG85QKV7	GO:0005829	1/98	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8V720H	GO:0003677	17/146	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8V720H	GO:0006313	14/146	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG8V720H	GO:0015074	14/146	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8V720H	GO:0004803	14/146	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG8V720H	GO:0007476	1/146	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8V720H	GO:0002121	1/146	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8N06W4	GO:0004190	1/18	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8N06W4	GO:0008270	1/18	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8N06W4	GO:0003676	1/18	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8N06W0	GO:0016788	36/152	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG8N06W0	GO:0090502	1/152	RNA phosphodiester bond hydrolysis, endonucleolytic	biological_process	"The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
EOG8N06W0	GO:0046872	1/152	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8N06W0	GO:0003723	1/152	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8N06W0	GO:0006955	1/152	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8N06W0	GO:0030247	1/152	polysaccharide binding	molecular_function	"Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah]
EOG8N06W0	GO:0005576	1/152	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8N06W0	GO:0005044	1/152	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8N06W0	GO:0008233	1/152	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8N06W0	GO:0004521	1/152	endoribonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG88GZJ7	GO:0003676	1/365	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88GZJ7	GO:0003677	1/365	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG88GZJ7	GO:0003899	1/365	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG88GZJ7	GO:0006351	1/365	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8CZDZX	GO:0003677	17/2665	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CZDZX	GO:0015074	6/2665	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8CZDZX	GO:0004803	6/2665	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG8CZDZX	GO:0006313	6/2665	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG8CZDZX	GO:0006355	3/2665	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8CZDZX	GO:0003676	3/2665	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CZDZX	GO:0016021	1/2665	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CZDZX	GO:0015171	1/2665	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8CZDZX	GO:0046872	1/2665	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CZDZX	GO:0008270	1/2665	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DFS2Z	GO:0008270	23/86	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DFS2Z	GO:0016567	1/86	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8DFS2Z	GO:0016197	1/86	endosomal transport	biological_process	"The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]
EOG8DFS2Z	GO:0005768	1/86	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG8DFS2Z	GO:0004842	1/86	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8CZDZF	GO:0043565	33/120	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8CZDZF	GO:0005634	33/120	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CZDZF	GO:0006351	32/120	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8CZDZF	GO:0003700	32/120	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8CZDZF	GO:0008301	1/120	DNA binding, bending	molecular_function	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]
EOG8CZDZF	GO:0006366	1/120	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8CZDZF	GO:0003705	1/120	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG8CZDZF	GO:0007389	1/120	pattern specification process	biological_process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
EOG8CZDZF	GO:0048806	1/120	genitalia development	biological_process	"The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid]
EOG8CZDZF	GO:0000122	1/120	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8CZDZF	GO:0008134	1/120	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8CZDZF	GO:0009888	1/120	tissue development	biological_process	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]
EOG8CZDZF	GO:0005667	1/120	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8CZDZF	GO:0051090	1/120	regulation of sequence-specific DNA binding transcription factor activity	biological_process	"Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]
EOG8CZDZF	GO:0003690	1/120	double-stranded DNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh]
EOG851H4X	GO:0016021	117/291	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG851H4X	GO:0007155	117/291	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG851H4X	GO:0048102	2/291	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG851H4X	GO:0005044	2/291	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG851H4X	GO:0016063	2/291	rhodopsin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
EOG851H4X	GO:0007602	2/291	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG851H4X	GO:0035071	2/291	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG851H4X	GO:0006898	2/291	receptor-mediated endocytosis	biological_process	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
EOG851H4X	GO:0002433	1/291	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	biological_process	"An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, GOC:mtg_15nov05, ISBN:0781735149]
EOG851H4X	GO:0006909	1/291	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG851H4X	GO:0006911	1/291	phagocytosis, engulfment	biological_process	"The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149]
EOG851H4X	GO:0006915	1/291	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG851H4X	GO:0006955	1/291	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG851H4X	GO:0046867	1/291	carotenoid transport	biological_process	"The directed movement of carotenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:ai]
EOG851H4X	GO:0016116	1/291	carotenoid metabolic process	biological_process	"The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684]
EOG851H4X	GO:0042116	1/291	macrophage activation	biological_process	"A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:14506301]
EOG851H4X	GO:0005886	1/291	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG851H4X	GO:0050764	1/291	regulation of phagocytosis	biological_process	"Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai]
EOG851H4X	GO:0004872	1/291	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG851H4X	GO:0043052	1/291	thermotaxis	biological_process	"The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
EOG851H4X	GO:0005764	1/291	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG85B3Z6	GO:0019789	31/81	SUMO transferase activity	molecular_function	"Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages." [GOC:rn, PMID:11031248, PMID:11265250]
EOG85B3Z6	GO:0000724	31/81	double-strand break repair via homologous recombination	biological_process	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]
EOG85B3Z6	GO:0030915	31/81	Smc5-Smc6 complex	cellular_component	"A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739]
EOG85B3Z6	GO:0008270	1/81	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GTNWV	GO:0000166	4/29	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8GTNWV	GO:0003676	4/29	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8PZMMN	GO:0005089	1/15	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8TF313	GO:0005089	8/48	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8TF313	GO:0046872	8/48	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG88KTV9	GO:0016301	1/63	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8TF316	GO:0009058	25/90	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG8TF316	GO:0016740	25/90	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8TF316	GO:0050821	1/90	protein stabilization	biological_process	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]
EOG8TF316	GO:0005739	1/90	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8TF316	GO:0005737	1/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8TF316	GO:0005743	1/90	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG80ZTCT	GO:0016787	26/181	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG80ZTCT	GO:0052689	3/181	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG80ZTCT	GO:0008152	1/181	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG80ZTCT	GO:0005737	1/181	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8G7FGB	GO:0005634	1/14	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8G7FGB	GO:0003700	1/14	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8G7FGB	GO:0006260	1/14	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8QRKN0	GO:0017183	1/64	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	biological_process	"The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380, RESID:AA0040]
EOG8QRKN0	GO:0046872	1/64	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TF31V	GO:0035091	25/85	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG8TF31V	GO:0060070	1/85	canonical Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488]
EOG8TF31V	GO:0061359	1/85	regulation of Wnt signaling pathway by Wnt protein secretion	biological_process	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signaling pathway by the controlled release of a Wnt protein from a cell." [GOC:bf, GOC:jl, PMID:19223472]
EOG8TF31V	GO:0006909	1/85	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8TF31V	GO:0005769	1/85	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG8TF31V	GO:0061355	1/85	Wnt protein secretion	biological_process	"The controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
EOG8TF31V	GO:0090263	1/85	positive regulation of canonical Wnt signaling pathway	biological_process	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]
EOG8TF31V	GO:0061357	1/85	positive regulation of Wnt protein secretion	biological_process	"Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
EOG8TF31V	GO:0030904	1/85	retromer complex	cellular_component	"A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35." [GOC:bf, PMID:26220253, PMID:9700157]
EOG8TF31V	GO:0006886	1/85	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8TF31V	GO:0035220	1/85	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8TF31V	GO:0050821	1/85	protein stabilization	biological_process	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]
EOG8TF31W	GO:0006412	20/79	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8TF31W	GO:0005840	3/79	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8TF31W	GO:0003723	1/79	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8TF31W	GO:0005763	1/79	mitochondrial small ribosomal subunit	cellular_component	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
EOG8TF31W	GO:0003735	1/79	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8TF31W	GO:0022627	1/79	cytosolic small ribosomal subunit	cellular_component	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]
EOG85F03H	GO:0030170	119/445	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG85F03H	GO:0006520	119/445	cellular amino acid metabolic process	biological_process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]
EOG85F03H	GO:0016831	110/445	carboxy-lyase activity	molecular_function	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]
EOG85F03H	GO:0004058	9/445	aromatic-L-amino-acid decarboxylase activity	molecular_function	"Catalysis of the reaction: L-amino acid + H+ = R-H + CO2." [EC:4.1.1.28]
EOG85F03H	GO:0016491	6/445	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG85F03H	GO:0006584	2/445	catecholamine metabolic process	biological_process	"The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0042302	2/445	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG85F03H	GO:0043052	2/445	thermotaxis	biological_process	"The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
EOG85F03H	GO:0040003	2/445	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG85F03H	GO:0004837	2/445	tyrosine decarboxylase activity	molecular_function	"Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25]
EOG85F03H	GO:0042423	2/445	catecholamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0007611	1/445	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG85F03H	GO:0048066	1/445	developmental pigmentation	biological_process	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
EOG85F03H	GO:0035220	1/445	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG85F03H	GO:0007626	1/445	locomotory behavior	biological_process	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
EOG85F03H	GO:0007619	1/445	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG85F03H	GO:0046592	1/445	polyamine oxidase activity	molecular_function	"Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380]
EOG85F03H	GO:0048148	1/445	behavioral response to cocaine	biological_process	"Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid]
EOG85F03H	GO:0048082	1/445	regulation of adult chitin-containing cuticle pigmentation	biological_process	"Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
EOG85F03H	GO:0048085	1/445	adult chitin-containing cuticle pigmentation	biological_process	"Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
EOG85F03H	GO:0007615	1/445	anesthesia-resistant memory	biological_process	"The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531]
EOG85F03H	GO:0006587	1/445	serotonin biosynthetic process from tryptophan	biological_process	"The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0048149	1/445	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG85F03H	GO:0009611	1/445	response to wounding	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators]
EOG85F03H	GO:0040040	1/445	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG85F03H	GO:0018991	1/445	oviposition	biological_process	"The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems]
EOG85F03H	GO:0019239	1/445	deaminase activity	molecular_function	"Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl]
EOG85F03H	GO:0040007	1/445	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG85F03H	GO:0008062	1/445	eclosion rhythm	biological_process	"The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043]
EOG85F03H	GO:0004398	1/445	histidine decarboxylase activity	molecular_function	"Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22]
EOG85F03H	GO:0006585	1/445	dopamine biosynthetic process from tyrosine	biological_process	"The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine." [GOC:bf, GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0007616	1/445	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG80ZTBK	GO:0016021	19/62	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80ZTBK	GO:0016757	1/62	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG80ZTBZ	GO:0022857	17/42	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG80ZTBZ	GO:0016021	17/42	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80S2Z3	GO:0016021	1/11	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8284GQ	GO:0005509	26/84	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8284GQ	GO:0004623	26/84	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG8284GQ	GO:0016042	26/84	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8284GQ	GO:0005576	20/84	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8284GQ	GO:0006644	20/84	phospholipid metabolic process	biological_process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8284GQ	GO:0004252	1/84	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8284GR	GO:0046872	22/79	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8284GR	GO:0004655	22/79	porphobilinogen synthase activity	molecular_function	"Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen." [EC:4.2.1.24, RHEA:24067]
EOG8284GR	GO:0006779	19/79	porphyrin-containing compound biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732]
EOG8284GR	GO:0033014	3/79	tetrapyrrole biosynthetic process	biological_process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah]
EOG8GJ255	GO:0033897	31/97	ribonuclease T2 activity	molecular_function	"Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.1]
EOG8GJ255	GO:0003723	31/97	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8GJ255	GO:0032504	1/97	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8GJ255	GO:0090501	1/97	RNA phosphodiester bond hydrolysis	biological_process	"The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
EOG8GJ255	GO:0006401	1/97	RNA catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]
EOG8GJ255	GO:0004540	1/97	ribonuclease activity	molecular_function	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]
EOG8GJ255	GO:0005615	1/97	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8284GX	GO:0000398	24/85	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8284GX	GO:0000166	24/85	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8284GX	GO:0017069	23/85	snRNA binding	molecular_function	"Interacting selectively and non-covalently with a small nuclear RNA (snRNA)." [GOC:mah]
EOG8284GX	GO:0030529	6/85	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8284GX	GO:0019013	5/85	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8284GX	GO:0003729	1/85	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8284GX	GO:0008380	1/85	RNA splicing	biological_process	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]
EOG8284GX	GO:0000381	1/85	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8284GX	GO:0097158	1/85	pre-mRNA intronic pyrimidine-rich binding	molecular_function	"Interacting selectively and non-covalently with a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624, PMID:16777844]
EOG8284GX	GO:0030619	1/85	U1 snRNA binding	molecular_function	"Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA)." [GOC:mah]
EOG8284GX	GO:0005685	1/85	U1 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U1." [GOC:krc, GOC:mah]
EOG8284GX	GO:0007539	1/85	primary sex determination, soma	biological_process	"The transmission of information about sexual status from the initial, general, determination to signals specific to the soma." [GOC:ems]
EOG8284GX	GO:0071013	1/85	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8284GX	GO:0008266	1/85	poly(U) RNA binding	molecular_function	"Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule." [GOC:mah]
EOG8284GX	GO:0030532	1/85	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8284GX	GO:0048477	1/85	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8284GX	GO:0005686	1/85	U2 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U2." [GOC:krc, GOC:mah]
EOG8284GX	GO:0071011	1/85	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8284GX	GO:0035614	1/85	snRNA stem-loop binding	molecular_function	"Interacting selectively and non-covalently with a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544]
EOG8284GX	GO:0019099	1/85	female germ-line sex determination	biological_process	"The determination of sex and sexual phenotype in a female organism's germ line." [GOC:mah]
EOG8284GX	GO:0005515	1/85	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8284GX	GO:0005634	1/85	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8284GX	GO:0030620	1/85	U2 snRNA binding	molecular_function	"Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA)." [GOC:jl]
EOG8284GX	GO:0043234	1/85	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8284GX	GO:0042802	1/85	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG847J7N	GO:0003677	22/137	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG847J7N	GO:0003676	20/137	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG847J7N	GO:0010628	1/137	positive regulation of gene expression	biological_process	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG847J7N	GO:0008270	1/137	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG847J7N	GO:2000495	1/137	regulation of cell proliferation involved in compound eye morphogenesis	biological_process	"Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]
EOG847J7N	GO:0051726	1/137	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG847J7N	GO:0042023	1/137	DNA endoreduplication	biological_process	"Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw]
EOG847J7N	GO:0006355	1/137	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG847J7N	GO:0048749	1/137	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG847J7N	GO:0006366	1/137	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG847J7N	GO:0006357	1/137	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG847J7N	GO:0005667	1/137	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG847J7N	GO:0051123	1/137	RNA polymerase II transcriptional preinitiation complex assembly	biological_process	"The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:10882737, PMID:15020047]
EOG847J7N	GO:0042981	1/137	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG847J7N	GO:0003700	1/137	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG847J7N	GO:0022416	1/137	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG847J7N	GO:0005634	1/137	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG847J7N	GO:0048813	1/137	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG847J7N	GO:2000278	1/137	regulation of DNA biosynthetic process	biological_process	"Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]
EOG847J7N	GO:0001745	1/137	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG847J7N	GO:0004222	1/137	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG847J7N	GO:0022008	1/137	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG847J7N	GO:0045035	1/137	sensory organ precursor cell division	biological_process	"The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597]
EOG847J7N	GO:0006260	1/137	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG847J7N	GO:0006264	1/137	mitochondrial DNA replication	biological_process	"The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai]
EOG847J7N	GO:0005700	1/137	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG847J7N	GO:0000976	1/137	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG847J7N	GO:0031012	1/137	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG847J7N	GO:0045893	1/137	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG847J7N	GO:0007052	1/137	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8F7R22	GO:0090175	1/84	regulation of establishment of planar polarity	biological_process	"Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8VQD5G	GO:0005875	23/96	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8VQD5G	GO:0007017	23/96	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8VQD5G	GO:0042623	1/96	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8VQD5G	GO:0030286	1/96	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8VQD5G	GO:0006200	1/96	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8VQD5G	GO:0007018	1/96	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8KH59C	GO:0003676	3/88	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KH59C	GO:0000712	1/88	resolution of meiotic recombination intermediates	biological_process	"The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]
EOG8KH59C	GO:0043234	1/88	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8KH59C	GO:0005515	1/88	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KH59C	GO:0003697	1/88	single-stranded DNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174]
EOG8NZX7M	GO:0016055	26/120	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG8NZX7M	GO:0072091	1/120	regulation of stem cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
EOG8NZX7M	GO:0005667	1/120	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8NZX7M	GO:0005875	1/120	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8NZX7M	GO:0045892	1/120	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8NZX7M	GO:0005515	1/120	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8NZX7M	GO:0060070	1/120	canonical Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488]
EOG8NZX7M	GO:0005634	1/120	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NZX7M	GO:0044212	1/120	transcription regulatory region DNA binding	molecular_function	"Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836]
EOG8NZX7M	GO:0008013	1/120	beta-catenin binding	molecular_function	"Interacting selectively and non-covalently with the beta subunit of the catenin complex." [GOC:bf]
EOG8NZX7M	GO:0010628	1/120	positive regulation of gene expression	biological_process	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8NZX7M	GO:0070491	1/120	repressing transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH]
EOG8NZX7M	GO:0043565	1/120	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NZX7M	GO:0030178	1/120	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8NZX7M	GO:0006366	1/120	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8NZX7M	GO:0003705	1/120	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG8NZX7M	GO:0006355	1/120	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8NZX7M	GO:0045610	1/120	regulation of hemocyte differentiation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG8NZX7M	GO:0007435	1/120	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8NZX7M	GO:0009880	1/120	embryonic pattern specification	biological_process	"The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
EOG8NZX7M	GO:0019900	1/120	kinase binding	molecular_function	"Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]
EOG8NZX7M	GO:0045893	1/120	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8NZX7M	GO:0030111	1/120	regulation of Wnt signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]
EOG8NZX7M	GO:0045944	1/120	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8NZX7M	GO:0035277	1/120	spiracle morphogenesis, open tracheal system	biological_process	"The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268]
EOG8NZX7M	GO:0007500	1/120	mesodermal cell fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437]
EOG8NZX7M	GO:0007476	1/120	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8NZX7M	GO:0007507	1/120	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8NZX7M	GO:0007367	1/120	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG8616N8	GO:0003676	7/1106	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8616N8	GO:0003677	3/1106	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8616N8	GO:0008270	3/1106	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8616N8	GO:0003964	2/1106	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8616N8	GO:0015074	2/1106	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8616N8	GO:0003723	2/1106	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8616N8	GO:0004190	1/1106	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8616N8	GO:0008237	1/1106	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8K0T47	GO:0008270	5/119	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8K0T47	GO:0003676	5/119	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K0T47	GO:0004190	2/119	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG80S2ZK	GO:0046872	3/16	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8284G8	GO:0016021	294/728	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8284G8	GO:0055085	283/728	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8284G8	GO:0005215	14/728	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8284G8	GO:0015114	10/728	phosphate ion transmembrane transporter activity	molecular_function	"Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai]
EOG8284G8	GO:0005886	2/728	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8284G8	GO:0006814	2/728	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8284G8	GO:0015293	2/728	symporter activity	molecular_function	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
EOG8284G8	GO:0005314	1/728	high-affinity glutamate transmembrane transporter activity	molecular_function	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.3.10.5]
EOG8284G8	GO:0015321	1/728	sodium-dependent phosphate transmembrane transporter activity	molecular_function	"Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions." [GOC:jl]
EOG8284G8	GO:0051938	1/728	L-glutamate import	biological_process	"The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah]
EOG8284G8	GO:0048190	1/728	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8284G8	GO:0006541	1/728	glutamine metabolic process	biological_process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
EOG8284G8	GO:0035725	1/728	sodium ion transmembrane transport	biological_process	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
EOG8284G8	GO:0001666	1/728	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG8284G8	GO:0007005	1/728	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8284G8	GO:0035435	1/728	phosphate ion transmembrane transport	biological_process	"The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
EOG8284G8	GO:0044341	1/728	sodium-dependent phosphate transport	biological_process	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl]
EOG8284G8	GO:0005436	1/728	sodium:phosphate symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai]
EOG8284G8	GO:0004930	1/728	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8M946W	GO:0004721	1/93	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8M946W	GO:0003012	1/93	muscle system process	biological_process	"A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio]
EOG8WDGRM	GO:0003735	47/309	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8WDGRM	GO:0005840	47/309	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8WDGRM	GO:0006412	47/309	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8WDGRM	GO:0005875	4/309	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8WDGRM	GO:0005634	4/309	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WDGRM	GO:0005829	3/309	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8WDGRM	GO:0003950	3/309	NAD+ ADP-ribosyltransferase activity	molecular_function	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]
EOG8WDGRM	GO:0009987	2/309	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8WDGRM	GO:0022008	1/309	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8WDGRM	GO:0046872	1/309	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WDGRM	GO:2000242	1/309	negative regulation of reproductive process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah]
EOG8WDGRM	GO:0051438	1/309	regulation of ubiquitin-protein transferase activity	biological_process	"Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb]
EOG8WDGRM	GO:0010992	1/309	ubiquitin homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell." [GOC:BHF, GOC:dph, GOC:tb]
EOG8WDGRM	GO:0031386	1/309	protein tag	molecular_function	"Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question." [GOC:go_curators]
EOG8WDGRM	GO:0006464	1/309	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG8WDGRM	GO:0045116	1/309	protein neddylation	biological_process	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]
EOG8WDGRM	GO:0048812	1/309	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8WDGRM	GO:0008283	1/309	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8WDGRM	GO:0007141	1/309	male meiosis I	biological_process	"A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah]
EOG8WDGRM	GO:0048515	1/309	spermatid differentiation	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid]
EOG8WDGRM	GO:0030431	1/309	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8WDGRM	GO:0031647	1/309	regulation of protein stability	biological_process	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]
EOG8WDGRM	GO:0006511	1/309	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8WDGRM	GO:0030162	1/309	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8WDGRM	GO:0008589	1/309	regulation of smoothened signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG8WDGRM	GO:0022625	1/309	cytosolic large ribosomal subunit	cellular_component	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]
EOG8WDGRM	GO:0006909	1/309	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8WDGRM	GO:0008340	1/309	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG841ST9	GO:0016020	1/16	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG841ST9	GO:0051781	1/16	positive regulation of cell division	biological_process	"Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai]
EOG81K1V8	GO:0005634	1/22	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81K1V8	GO:0043565	1/22	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG81K1V8	GO:0003700	1/22	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG83R62Q	GO:0003676	55/341	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83R62Q	GO:0005622	1/341	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG83R62Q	GO:0008270	1/341	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83R62Q	GO:0046872	1/341	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83R62Q	GO:0003964	1/341	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG83R62Q	GO:0003723	1/341	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG83R62Q	GO:0042981	1/341	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8V9X5W	GO:0004527	2/82	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8V9X5W	GO:0005737	1/82	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8V9X5W	GO:0000176	1/82	nuclear exosome (RNase complex)	cellular_component	"Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]
EOG8V9X5W	GO:0010468	1/82	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8V9X5S	GO:0005787	26/156	signal peptidase complex	cellular_component	"A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509]
EOG8V9X5S	GO:0006465	26/156	signal peptide processing	biological_process	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]
EOG8V9X5S	GO:0008233	26/156	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8V9X5S	GO:0016021	26/156	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V9X5S	GO:0003824	20/156	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8V9X5S	GO:0004300	1/156	enoyl-CoA hydratase activity	molecular_function	"Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.17]
EOG8V9X5S	GO:0005875	1/156	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8V9X5S	GO:0009631	1/156	cold acclimation	biological_process	"Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr]
EOG8V9X5S	GO:0004490	1/156	methylglutaconyl-CoA hydratase activity	molecular_function	"Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O." [EC:4.2.1.18, RHEA:21539]
EOG8V9X5J	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V9X5J	GO:0006633	1/5	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8V9X5J	GO:0016717	1/5	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]
EOG8V9X5D	GO:0003676	7/41	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M0HGK	GO:0016021	26/94	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M0HGK	GO:0001745	1/94	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8M0HGK	GO:0006096	1/94	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8M0HGK	GO:0005886	1/94	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8M0HGK	GO:0048477	1/94	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8M0HGK	GO:0004743	1/94	pyruvate kinase activity	molecular_function	"Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40]
EOG8M0HGK	GO:0000287	1/94	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8M0HGK	GO:0030955	1/94	potassium ion binding	molecular_function	"Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah]
EOG8M0HGK	GO:0046956	1/94	positive phototaxis	biological_process	"The directed movement of a cell or organism towards a source of light." [GOC:ai]
EOG8M3CSV	GO:0016021	3/25	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83R628	GO:0003676	26/225	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83R628	GO:0005634	1/225	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83R628	GO:0046872	1/225	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8M0HGM	GO:0005509	28/92	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8M0HGM	GO:0005703	1/92	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG8M0HGM	GO:0032440	1/92	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8M0HGM	GO:0006325	1/92	chromatin organization	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
EOG8M0HGM	GO:0005737	1/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8M0HGM	GO:0009047	1/92	dosage compensation by hyperactivation of X chromosome	biological_process	"Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577]
EOG8M0HGM	GO:0005700	1/92	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8M0HGM	GO:0045893	1/92	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8M0HGM	GO:0005634	1/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8M0HGM	GO:0006265	1/92	DNA topological change	biological_process	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]
EOG873S6H	GO:0004719	11/52	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77]
EOG81K1VN	GO:0003676	2/52	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG81K1VN	GO:0000502	1/52	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG8HX7FR	GO:0016020	23/75	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HX7FR	GO:0007264	23/75	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8HX7FR	GO:0006184	23/75	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8HX7FR	GO:0005525	23/75	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8HX7FR	GO:0004767	1/75	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8HX7FR	GO:0005622	1/75	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8TTJXV	GO:0006886	21/93	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8TTJXV	GO:0005634	20/93	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TTJXV	GO:0030621	1/93	U4 snRNA binding	molecular_function	"Interacting selectively and non-covalently with the U4 small nuclear RNA (U4 snRNA)." [GOC:jl]
EOG8TTJXV	GO:0015030	1/93	Cajal body	cellular_component	"A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]
EOG8TTJXV	GO:0030620	1/93	U2 snRNA binding	molecular_function	"Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA)." [GOC:jl]
EOG8TTJXV	GO:0045465	1/93	R8 cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor." [PMID:11880339]
EOG8TTJXV	GO:0005515	1/93	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8TTJXV	GO:0042675	1/93	compound eye cone cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu]
EOG8TTJXV	GO:0016318	1/93	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG8TTJXV	GO:0007474	1/93	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG8TTJXV	GO:0035311	1/93	wing cell fate specification	biological_process	"The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment." [PMID:10860999]
EOG8TTJXV	GO:0048749	1/93	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8TTJXV	GO:0005938	1/93	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8TTJXV	GO:0048471	1/93	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8TTJXV	GO:0006608	1/93	snRNP protein import into nucleus	biological_process	"The directed movement of a small nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai]
EOG8TTJXV	GO:0006606	1/93	protein import into nucleus	biological_process	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]
EOG8TTJXV	GO:0005737	1/93	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8TTJXV	GO:0008586	1/93	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG8TTJXV	GO:0042052	1/93	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8TTJXV	GO:0007173	1/93	epidermal growth factor receptor signaling pathway	biological_process	"A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933]
EOG8TTJXV	GO:0030619	1/93	U1 snRNA binding	molecular_function	"Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA)." [GOC:mah]
EOG8TTJXV	GO:0008283	1/93	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8TTJXV	GO:0000189	1/93	MAPK import into nucleus	biological_process	"The directed movement of a MAP kinase to the nucleus upon activation." [PMID:9561267]
EOG8TTJXV	GO:0016203	1/93	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8TTJXV	GO:0043524	1/93	negative regulation of neuron apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
EOG8TTJXV	GO:0007169	1/93	transmembrane receptor protein tyrosine kinase signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
EOG8TTJXV	GO:0030576	1/93	Cajal body organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238]
EOG8TTJXV	GO:0007476	1/93	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8TTJXV	GO:0046331	1/93	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG83FK9M	GO:0008270	74/433	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83FK9M	GO:0009058	72/433	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG83FK9M	GO:0016491	46/433	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG83FK9M	GO:0016747	38/433	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG83FK9M	GO:0016788	37/433	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG83FK9M	GO:0004313	36/433	[acyl-carrier-protein] S-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38]
EOG83FK9M	GO:0004315	35/433	3-oxoacyl-[acyl-carrier-protein] synthase activity	molecular_function	"Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.41]
EOG83FK9M	GO:0004319	35/433	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	molecular_function	"Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10]
EOG83FK9M	GO:0016295	35/433	myristoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14, MetaCyc:RXN-10727]
EOG83FK9M	GO:0004320	35/433	oleoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14]
EOG83FK9M	GO:0016296	35/433	palmitoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14, MetaCyc:RXN-9549]
EOG83FK9M	GO:0004316	35/433	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
EOG83FK9M	GO:0004314	35/433	[acyl-carrier-protein] S-malonyltransferase activity	molecular_function	"Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39]
EOG83FK9M	GO:0004317	35/433	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.61]
EOG83FK9M	GO:0016740	23/433	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG83FK9M	GO:0004312	19/433	fatty acid synthase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85]
EOG83FK9M	GO:0047451	3/433	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [EC:4.2.1.59, MetaCyc:4.2.1.59-RXN]
EOG83FK9M	GO:0003960	2/433	NADPH:quinone reductase activity	molecular_function	"Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5]
EOG83FK9M	GO:0005811	2/433	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG83FK9M	GO:0050111	1/433	mycocerosate synthase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + 7n H(+) + n methylmalonyl-CoA + 2n NADPH = n CO(2) + n CoA + n H(2)O + multi-methyl-branched acyl-CoA + 2n NADP(+)." [EC:2.3.1.111, RHEA:10591]
EOG841STZ	GO:0004843	1/73	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG841STZ	GO:0003964	1/73	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG841STZ	GO:0006511	1/73	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8TQPRX	GO:0016787	1/20	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG82FW10	GO:0003954	1/72	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8X3KHJ	GO:0008270	126/815	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X3KHJ	GO:0003676	118/815	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X3KHJ	GO:0003964	12/815	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8X3KHJ	GO:0003723	12/815	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8X3KHJ	GO:0003677	1/815	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X3KHJ	GO:0016192	1/815	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8X3KHJ	GO:0015074	1/815	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8X3KHJ	GO:0016020	1/815	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82Z749	GO:0000166	4/62	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG82Z749	GO:0003676	4/62	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82Z749	GO:0016779	1/62	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG82Z749	GO:0046872	1/62	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82Z749	GO:0008270	1/62	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SR0BQ	GO:0008233	1/47	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8SBHC1	GO:0005524	29/90	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SBHC1	GO:0004814	29/90	arginine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19]
EOG8SBHC1	GO:0006420	29/90	arginyl-tRNA aminoacylation	biological_process	"The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8SBHC1	GO:0005737	26/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RZ1HJ	GO:0000166	3/17	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8RZ1HJ	GO:0003676	2/17	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CRPF7	GO:0042254	22/83	ribosome biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
EOG8CRPF7	GO:0003723	2/83	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CRPF7	GO:0005737	1/83	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CRPF7	GO:0016042	1/83	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8CRPF7	GO:0042273	1/83	ribosomal large subunit biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]
EOG8CRPF7	GO:0005634	1/83	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CRPF7	GO:0003847	1/83	1-alkyl-2-acetylglycerophosphocholine esterase activity	molecular_function	"Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]
EOG8CRPF7	GO:0006364	1/83	rRNA processing	biological_process	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
EOG8CRPF7	GO:0005622	1/83	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8CRPF7	GO:0005525	1/83	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8GMXBH	GO:0006370	31/135	7-methylguanosine mRNA capping	biological_process	"Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685]
EOG8GMXBH	GO:0004484	31/135	mRNA guanylyltransferase activity	molecular_function	"Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50]
EOG8GMXBH	GO:0008138	28/135	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG8GMXBH	GO:0004725	27/135	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8GMXBH	GO:0004651	23/135	polynucleotide 5'-phosphatase activity	molecular_function	"Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33]
EOG8GMXBH	GO:0005634	23/135	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GMXBH	GO:0004527	1/135	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8GMXBH	GO:0010181	1/135	FMN binding	molecular_function	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]
EOG8GMXBH	GO:0003676	1/135	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GMXBH	GO:0051539	1/135	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8GMXBH	GO:0008137	1/135	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8GMXBH	GO:0016491	1/135	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8GMXBH	GO:0006470	1/135	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8BGCCB	GO:0000122	5/35	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8BGCCB	GO:0016567	5/35	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8BGCCB	GO:0008270	4/35	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BGCCB	GO:0043066	2/35	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8BGCCB	GO:0071157	2/35	negative regulation of cell cycle arrest	biological_process	"Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases." [GOC:mah]
EOG8BGCCB	GO:0016874	2/35	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8BGCCB	GO:0005634	2/35	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BGCCB	GO:0003676	1/35	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GMXB7	GO:0005524	24/85	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8GMXB7	GO:0008026	24/85	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8GMXB7	GO:0003723	21/85	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8GMXB7	GO:0003676	3/85	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GMXB7	GO:0008152	1/85	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8GMXB7	GO:0004386	1/85	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8GMXB0	GO:0008233	12/66	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8CC6FD	GO:0006355	25/87	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8CC6FD	GO:0005634	24/87	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CC6FD	GO:0032783	1/87	ELL-EAF complex	cellular_component	"A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae." [PMID:17150956]
EOG8CC6FD	GO:0005674	1/87	transcription factor TFIIF complex	cellular_component	"A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077]
EOG8CC6FD	GO:0005669	1/87	transcription factor TFIID complex	cellular_component	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]
EOG8CC6FD	GO:0006367	1/87	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG8HX7G8	GO:0006281	13/83	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8HX7G8	GO:0000781	13/83	chromosome, telomeric region	cellular_component	"The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh]
EOG8HX7G8	GO:0007126	13/83	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8HX7G8	GO:0045003	1/83	double-strand break repair via synthesis-dependent strand annealing	biological_process	"SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855]
EOG8HX7G8	GO:0007095	1/83	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8HX7G8	GO:0000723	1/83	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8HX7G8	GO:0008630	1/83	intrinsic apoptotic signaling pathway in response to DNA damage	biological_process	"A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]
EOG8HX7G8	GO:0006974	1/83	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8HX7G8	GO:0016233	1/83	telomere capping	biological_process	"A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055]
EOG8HX7G8	GO:0042770	1/83	signal transduction in response to DNA damage	biological_process	"A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators]
EOG8HX7G8	GO:0051276	1/83	chromosome organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8CRPFM	GO:0016021	17/50	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CRPFM	GO:0007155	17/50	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8CRPFM	GO:0050896	2/50	response to stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
EOG8CRPFM	GO:0007608	2/50	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8CRPFM	GO:0005886	2/50	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG82Z74B	GO:0005524	24/82	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82Z74B	GO:0004674	21/82	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG82Z74B	GO:0046872	16/82	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82Z74B	GO:0035556	16/82	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG82Z74B	GO:0004697	3/82	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG82Z74B	GO:0004672	1/82	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG82Z74B	GO:0006468	1/82	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG88D3B2	GO:0005840	2/80	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG88D3B2	GO:0042254	1/80	ribosome biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
EOG88D3B2	GO:0005730	1/80	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8Q87DB	GO:0016021	27/84	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Q87DB	GO:0006810	26/84	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8Q87DB	GO:0030133	1/84	transport vesicle	cellular_component	"Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]
EOG8Q87DB	GO:0005215	1/84	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8Q87DB	GO:0061357	1/84	positive regulation of Wnt protein secretion	biological_process	"Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
EOG8Q87DB	GO:0048042	1/84	regulation of post-mating oviposition	biological_process	"Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb, PMID:11932766]
EOG8Q87DB	GO:0022008	1/84	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8Q87DB	GO:0048193	1/84	Golgi vesicle transport	biological_process	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG8Q87DB	GO:0000003	1/84	reproduction	biological_process	"The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732]
EOG8Q87DC	GO:0040007	9/56	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG8Q87DC	GO:0005576	3/56	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Z654D	GO:0005198	28/93	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8Z654D	GO:0030130	28/93	clathrin coat of trans-Golgi network vesicle	cellular_component	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]
EOG8Z654D	GO:0030132	28/93	clathrin coat of coated pit	cellular_component	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]
EOG8Z654D	GO:0006886	28/93	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8Z654D	GO:0016192	27/93	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8Z654D	GO:0030136	1/93	clathrin-coated vesicle	cellular_component	"A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]
EOG8Z654D	GO:0030125	1/93	clathrin vesicle coat	cellular_component	"A clathrin coat found on a vesicle." [GOC:mah]
EOG8Z654D	GO:0016183	1/93	synaptic vesicle coating	biological_process	"A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:curators, PMID:10099709]
EOG8Z654D	GO:0008021	1/93	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8Z654D	GO:0030135	1/93	coated vesicle	cellular_component	"Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]
EOG8Z654D	GO:0005905	1/93	coated pit	cellular_component	"A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]
EOG8Z654D	GO:0007269	1/93	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8Z654D	GO:0072583	1/93	clathrin-mediated endocytosis	biological_process	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]
EOG8ZCWJX	GO:0005975	67/249	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8ZCWJX	GO:0004370	42/249	glycerol kinase activity	molecular_function	"Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21647]
EOG8ZCWJX	GO:0006072	39/249	glycerol-3-phosphate metabolic process	biological_process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]
EOG8ZCWJX	GO:0016773	25/249	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8ZCWJX	GO:0016301	22/249	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8ZCWJX	GO:0046167	2/249	glycerol-3-phosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]
EOG8KM1KN	GO:0005840	3/72	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8ZCWJR	GO:0003756	25/91	protein disulfide isomerase activity	molecular_function	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1]
EOG8ZCWJR	GO:0016671	25/91	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]
EOG8ZCWJR	GO:0005783	25/91	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8ZCWJR	GO:0005789	1/91	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8ZCWJR	GO:0051085	1/91	chaperone mediated protein folding requiring cofactor	biological_process	"The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb]
EOG8ZCWJR	GO:0016491	1/91	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8RNDS4	GO:0005634	23/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RNDS4	GO:0003700	22/92	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8RNDS4	GO:0000976	16/92	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8RNDS4	GO:0043565	7/92	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8RNDS4	GO:0007417	1/92	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8RNDS4	GO:0003677	1/92	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RNDS4	GO:0000122	1/92	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8RNDS4	GO:0030182	1/92	neuron differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
EOG8RNDS4	GO:0006366	1/92	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8RNDS4	GO:0003705	1/92	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG8RNDS4	GO:0010629	1/92	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8RNDS4	GO:0045944	1/92	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8RNDS4	GO:0070491	1/92	repressing transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH]
EOG8G1PZ0	GO:0016881	44/171	acid-amino acid ligase activity	molecular_function	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
EOG8G1PZ0	GO:0004842	6/171	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8G1PZ0	GO:0005524	2/171	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8G1PZ0	GO:0048477	1/171	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8G1PZ0	GO:0051276	1/171	chromosome organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8G1PZ0	GO:0007140	1/171	male meiosis	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
EOG8G1PZ0	GO:0007067	1/171	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8G1PZ0	GO:0006511	1/171	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8G1PZ0	GO:0031647	1/171	regulation of protein stability	biological_process	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]
EOG8G1PZ0	GO:0005515	1/171	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8G1PZ0	GO:0005875	1/171	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8G1PZ0	GO:0016567	1/171	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8G1PZ0	GO:0045676	1/171	regulation of R7 cell differentiation	biological_process	"Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators]
EOG8G1PZ0	GO:0048132	1/171	female germ-line stem cell asymmetric division	biological_process	"The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu]
EOG8G1PZ0	GO:0007286	1/171	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG8G1PZ0	GO:0001745	1/171	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8G1PZ0	GO:0019915	1/171	lipid storage	biological_process	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]
EOG8G1PZ0	GO:0022008	1/171	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8G1PZ0	GO:0030718	1/171	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8G1PZ0	GO:0001751	1/171	compound eye photoreceptor cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
EOG8G1PZ0	GO:0016322	1/171	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG8G1PZ0	GO:0008054	1/171	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation	biological_process	"The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions via the negative regulation of a cyclin-dependent kinase." [GOC:mah, PMID:15840442]
EOG8G1PZ1	GO:0015074	13/60	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8G1PZ1	GO:0003676	13/60	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8G1PZ1	GO:0005634	2/60	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8G1PZ8	GO:0046854	27/181	phosphatidylinositol phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]
EOG8G1PZ8	GO:0016881	27/181	acid-amino acid ligase activity	molecular_function	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
EOG8G1PZ8	GO:0052833	3/181	inositol monophosphate 4-phosphatase activity	molecular_function	"Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25]
EOG8G1PZ8	GO:0052832	3/181	inositol monophosphate 3-phosphatase activity	molecular_function	"Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25]
EOG8G1PZ8	GO:0008934	3/181	inositol monophosphate 1-phosphatase activity	molecular_function	"Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25]
EOG8G1PZ8	GO:0046872	2/181	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8G1PZ8	GO:0006021	2/181	inositol biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, ISBN:0198547684]
EOG8G1PZ8	GO:0006661	2/181	phosphatidylinositol biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [CHEBI:28874, ISBN:0198506732]
EOG8G1PZ8	GO:0005737	2/181	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8G1PZ8	GO:0006796	2/181	phosphate-containing compound metabolic process	biological_process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]
EOG8G1PZ8	GO:0007165	2/181	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8G1PZ8	GO:0004842	2/181	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8G1PZ8	GO:0016021	2/181	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G1PZ8	GO:0016311	2/181	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG8G7FFM	GO:0005634	384/651	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8G7FFM	GO:0000786	384/651	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8G7FFM	GO:0003677	384/651	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8G7FFM	GO:0006334	384/651	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8G7FFM	GO:0005811	50/651	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8G7FFM	GO:0051298	17/651	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8G7FFM	GO:0006281	1/651	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8G7FFM	GO:0005701	1/651	polytene chromosome chromocenter	cellular_component	"A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012]
EOG8G7FFM	GO:0071168	1/651	protein localization to chromatin	biological_process	"Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah]
EOG8G7FFM	GO:0005700	1/651	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8G7FFM	GO:0006974	1/651	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8G7FFM	GO:0005694	1/651	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8G7FFM	GO:0007275	1/651	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8J9QF3	GO:0046872	29/105	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8J9QF3	GO:0003677	23/105	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8J9QF3	GO:0006357	1/105	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8J9QF3	GO:0043565	1/105	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8J9QF3	GO:0009792	1/105	embryo development ending in birth or egg hatching	biological_process	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
EOG8J9QF3	GO:0006351	1/105	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8J9QF3	GO:0045893	1/105	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8J9QF3	GO:0005634	1/105	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8J9QF3	GO:0050776	1/105	regulation of immune response	biological_process	"Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
EOG8J9QF3	GO:0005700	1/105	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8J9QF3	GO:0003700	1/105	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8G7FFX	GO:0003676	4/30	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8D81KT	GO:0004725	23/95	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8D81KT	GO:0016805	5/95	dipeptidase activity	molecular_function	"Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com]
EOG8D81KT	GO:0031225	5/95	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG8D81KT	GO:0046872	5/95	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8D81KT	GO:0008239	4/95	dipeptidyl-peptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]
EOG8D81KT	GO:0008235	4/95	metalloexopeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]
EOG8D81KT	GO:0050254	2/95	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8D81KT	GO:0035335	1/95	peptidyl-tyrosine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
EOG8D81KT	GO:0008237	1/95	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8D81KT	GO:0006470	1/95	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8N06V7	GO:0003676	9/45	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8N06V7	GO:0015074	8/45	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8N06V7	GO:0003964	5/45	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8N06V7	GO:0003723	5/45	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8N06V7	GO:0008270	3/45	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8N06V7	GO:0004190	2/45	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8N06V7	GO:0003677	1/45	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8N06V7	GO:0006310	1/45	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8N06VG	GO:0005622	23/87	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8N06VG	GO:0005856	1/87	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8N06VG	GO:0005546	1/87	phosphatidylinositol-4,5-bisphosphate binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]
EOG8N06VG	GO:0051015	1/87	actin filament binding	molecular_function	"Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]
EOG8N06VG	GO:0005547	1/87	phosphatidylinositol-3,4,5-trisphosphate binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl]
EOG8N06VG	GO:0005737	1/87	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8N06VG	GO:0022416	1/87	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8N06VG	GO:0001786	1/87	phosphatidylserine binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]
EOG8N06VG	GO:0016301	1/87	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8N06VG	GO:0003779	1/87	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8CG2R2	GO:0006355	1/30	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8J9QFX	GO:0016021	25/86	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J9QFX	GO:0048489	1/86	synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr]
EOG8J9QFX	GO:0016079	1/86	synaptic vesicle exocytosis	biological_process	"Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
EOG8J9QFX	GO:0022008	1/86	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG85TG4K	GO:0007018	1/87	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG85TG4K	GO:0006200	1/87	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG85TG4K	GO:0048813	1/87	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG85TG4K	GO:0016319	1/87	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG85TG4K	GO:0042623	1/87	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG85TG4K	GO:0005875	1/87	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG85TG4K	GO:0030286	1/87	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8SN43D	GO:0016021	1/18	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G7FF9	GO:0005525	3/35	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8G7FF9	GO:0007264	3/35	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8RV55T	GO:0003723	17/88	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RV55T	GO:0006397	17/88	mRNA processing	biological_process	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]
EOG8RV55T	GO:0005737	17/88	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RV55T	GO:0005634	17/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RV55T	GO:0016747	1/88	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8RV55T	GO:0046331	1/88	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG86HJRG	GO:0018342	27/91	protein prenylation	biological_process	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]
EOG86HJRG	GO:0008318	24/91	protein prenyltransferase activity	molecular_function	"Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah]
EOG86HJRG	GO:0004660	3/91	protein farnesyltransferase activity	molecular_function	"Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate." [EC:2.5.1.58, PMID:8621375]
EOG86HJRG	GO:0004662	1/91	CAAX-protein geranylgeranyltransferase activity	molecular_function	"Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375]
EOG86HJRK	GO:0008137	24/84	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8RV55Z	GO:0004497	3/49	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8RV55Z	GO:0016705	3/49	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8RV55Z	GO:0020037	3/49	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8RV55Z	GO:0005506	3/49	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG86HJRS	GO:0019318	76/195	hexose metabolic process	biological_process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
EOG86HJRS	GO:0030246	76/195	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG86HJRS	GO:0004034	60/195	aldose 1-epimerase activity	molecular_function	"Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3]
EOG86HJRS	GO:0016853	16/195	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG86HJRS	GO:0005576	1/195	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG85HVBX	GO:0016301	2/83	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG85HVBX	GO:0016905	1/83	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG85HVBX	GO:0008270	1/83	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83XXJM	GO:0016021	12/54	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83XXJM	GO:0004930	7/54	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG83XXJM	GO:0004983	5/54	neuropeptide Y receptor activity	molecular_function	"Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
EOG83XXJM	GO:0050254	2/54	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8BGC9V	GO:0005509	12/43	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8BGC9V	GO:0004623	12/43	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG8BGC9V	GO:0016042	12/43	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8BGC9V	GO:0005576	11/43	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8BGC9V	GO:0006644	11/43	phospholipid metabolic process	biological_process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG83XXJC	GO:0016740	3/372	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG83XXJC	GO:0005634	1/372	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83XXJC	GO:0008168	1/372	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG83XXJC	GO:0008270	1/372	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83XXJC	GO:0022008	1/372	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG83XXJC	GO:0005737	1/372	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8VX4NB	GO:0043565	25/89	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8VX4NB	GO:0005634	25/89	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VX4NB	GO:0003700	25/89	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8VX4NB	GO:0035071	1/89	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8VX4NB	GO:0060322	1/89	head development	biological_process	"The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph]
EOG8VX4NB	GO:0042803	1/89	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8VX4NB	GO:0046982	1/89	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8VX4NB	GO:0045944	1/89	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8VX4NB	GO:0048102	1/89	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG870WZN	GO:0005524	52/162	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG870WZN	GO:0016226	48/162	iron-sulfur cluster assembly	biological_process	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]
EOG870WZN	GO:0051539	48/162	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG870WZN	GO:0046872	48/162	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG870WZN	GO:0005737	33/162	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG870WZN	GO:0005829	15/162	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG870WZN	GO:0051536	15/162	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG870WZN	GO:0017111	11/162	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8VX4NG	GO:0016021	42/115	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VX4NG	GO:0006810	31/115	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8VX4NG	GO:0055085	10/115	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8VX4NG	GO:0006909	1/115	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8VX4NG	GO:0035002	1/115	liquid clearance, open tracheal system	biological_process	"The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352]
EOG8VX4NG	GO:0003382	1/115	epithelial cell morphogenesis	biological_process	"The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8VX4NG	GO:0005743	1/115	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8S4RWS	GO:0006909	1/76	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8S4RWV	GO:0008137	17/92	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8S4RWV	GO:0042773	3/92	ATP synthesis coupled electron transport	biological_process	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363]
EOG8S4RWV	GO:0016020	1/92	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8S4RWV	GO:0004129	1/92	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8S4RWV	GO:0016021	1/92	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S4RWV	GO:0008080	1/92	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG8S4RWV	GO:0005743	1/92	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8S4RWV	GO:0070469	1/92	respiratory chain	cellular_component	"The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684]
EOG8S4RWV	GO:0005507	1/92	copper ion binding	molecular_function	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]
EOG8GTNTH	GO:0046872	1/33	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GTNTH	GO:0008270	1/33	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GTNTH	GO:0005634	1/33	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GTNTH	GO:0019867	1/33	outer membrane	cellular_component	"The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators]
EOG8BGC99	GO:0006030	26/102	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8BGC99	GO:0005576	26/102	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8BGC99	GO:0008061	26/102	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8BGC99	GO:0031012	1/102	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8BGC99	GO:0005201	1/102	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG8FXTPX	GO:0005525	83/290	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8FXTPX	GO:0007264	81/290	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8FXTPX	GO:0005622	81/290	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8FXTPX	GO:0016020	77/290	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8FXTPX	GO:0005886	5/290	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8FXTPX	GO:0004767	4/290	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8FXTPX	GO:0031532	4/290	actin cytoskeleton reorganization	biological_process	"A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]
EOG8FXTPX	GO:0005912	4/290	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8FXTPX	GO:0035099	4/290	hemocyte migration	biological_process	"The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551]
EOG8FXTPX	GO:0007391	4/290	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8FXTPX	GO:0090303	4/290	positive regulation of wound healing	biological_process	"Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF]
EOG8FXTPX	GO:0007254	4/290	JNK cascade	biological_process	"An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974]
EOG8FXTPX	GO:0007275	3/290	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8FXTPX	GO:0050770	3/290	regulation of axonogenesis	biological_process	"Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]
EOG8FXTPX	GO:0007394	3/290	dorsal closure, elongation of leading edge cells	biological_process	"The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138]
EOG8FXTPX	GO:0051017	3/290	actin filament bundle assembly	biological_process	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
EOG8FXTPX	GO:0006184	3/290	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8FXTPX	GO:0006909	3/290	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8FXTPX	GO:0008258	3/290	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8FXTPX	GO:0003924	3/290	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8FXTPX	GO:0045185	3/290	maintenance of protein location	biological_process	"Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf]
EOG8FXTPX	GO:0035011	3/290	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG8FXTPX	GO:0030032	3/290	lamellipodium assembly	biological_process	"Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194]
EOG8FXTPX	GO:0007390	3/290	germ-band shortening	biological_process	"The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138]
EOG8FXTPX	GO:0005515	3/290	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FXTPX	GO:0046843	3/290	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8FXTPX	GO:0035010	3/290	encapsulation of foreign target	biological_process	"Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920]
EOG8FXTPX	GO:0007435	3/290	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8FXTPX	GO:0045860	3/290	positive regulation of protein kinase activity	biological_process	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
EOG8FXTPX	GO:0006974	2/290	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8FXTPX	GO:0007424	2/290	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8FXTPX	GO:0050975	2/290	sensory perception of touch	biological_process	"The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]
EOG8FXTPX	GO:0002009	2/290	morphogenesis of an epithelium	biological_process	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
EOG8FXTPX	GO:0008045	2/290	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8FXTPX	GO:0007411	2/290	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8FXTPX	GO:0007015	2/290	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8FXTPX	GO:0007520	2/290	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG8FXTPX	GO:0002433	2/290	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	biological_process	"An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, GOC:mtg_15nov05, ISBN:0781735149]
EOG8FXTPX	GO:0031175	2/290	neuron projection development	biological_process	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]
EOG8FXTPX	GO:0007426	2/290	tracheal outgrowth, open tracheal system	biological_process	"The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8FXTPX	GO:0048813	2/290	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8FXTPX	GO:0030707	2/290	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8FXTPX	GO:0042067	2/290	establishment of ommatidial planar polarity	biological_process	"The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
EOG8FXTPX	GO:0030036	2/290	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8FXTPX	GO:0016203	2/290	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8FXTPX	GO:0051491	2/290	positive regulation of filopodium assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG8FXTPX	GO:0000902	2/290	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8FXTPX	GO:0016028	2/290	rhabdomere	cellular_component	"The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774]
EOG8FXTPX	GO:0097206	2/290	nephrocyte filtration	biological_process	"The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929]
EOG8FXTPX	GO:0032794	2/290	GTPase activating protein binding	molecular_function	"Interacting selectively and non-covalently with a GTPase activating protein." [GOC:nln]
EOG8FXTPX	GO:0030866	2/290	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8FXTPX	GO:0034334	2/290	adherens junction maintenance	biological_process	"The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah]
EOG8FXTPX	GO:0007266	2/290	Rho protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf]
EOG8FXTPX	GO:0007516	1/290	hemocyte development	biological_process	"The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG8FXTPX	GO:0016199	1/290	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG8FXTPX	GO:0007017	1/290	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8FXTPX	GO:0010592	1/290	positive regulation of lamellipodium assembly	biological_process	"Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG8FXTPX	GO:0051450	1/290	myoblast proliferation	biological_process	"The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle]
EOG8FXTPX	GO:0051963	1/290	regulation of synapse assembly	biological_process	"Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
EOG8FXTPX	GO:0007413	1/290	axonal fasciculation	biological_process	"The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh]
EOG8FXTPX	GO:0007617	1/290	mating behavior	biological_process	"The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph]
EOG8FXTPX	GO:0030041	1/290	actin filament polymerization	biological_process	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG8FXTPX	GO:0005829	1/290	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8FXTPX	GO:0060446	1/290	branching involved in open tracheal system development	biological_process	"The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph]
EOG8FXTPX	GO:0045177	1/290	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8FXTPX	GO:0051726	1/290	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8FXTPX	GO:0035320	1/290	imaginal disc-derived wing hair site selection	biological_process	"Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally." [GOC:mtg_transport, ISBN:0815340729, PMID:8947551]
EOG8FXTPX	GO:0008347	1/290	glial cell migration	biological_process	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
EOG8FXTPX	GO:0007422	1/290	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8FXTPX	GO:0007396	1/290	suture of dorsal opening	biological_process	"Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138]
EOG8FXTPX	GO:0010593	1/290	negative regulation of lamellipodium assembly	biological_process	"Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG8FXTPX	GO:0005938	1/290	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8FXTPX	GO:0071907	1/290	determination of digestive tract left/right asymmetry	biological_process	"Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:cvs]
EOG8FXTPX	GO:0048615	1/290	embryonic anterior midgut (ectodermal) morphogenesis	biological_process	"The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc]
EOG8FXTPX	GO:0042742	1/290	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8FXTPX	GO:0045200	1/290	establishment of neuroblast polarity	biological_process	"The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]
EOG8FXTPX	GO:0010883	1/290	regulation of lipid storage	biological_process	"Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
EOG8FXTPX	GO:0008360	1/290	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8FXTPX	GO:0048747	1/290	muscle fiber development	biological_process	"The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
EOG8FXTPX	GO:0007631	1/290	feeding behavior	biological_process	"Behavior associated with the intake of food." [GOC:mah]
EOG8FXTPX	GO:0030011	1/290	maintenance of cell polarity	biological_process	"The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8FXTPX	GO:0002118	1/290	aggressive behavior	biological_process	"A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd]
EOG8FXTPX	GO:0030031	1/290	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG8FXTPX	GO:0007286	1/290	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG8FXTPX	GO:0046331	1/290	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8FXTPX	GO:0019897	1/290	extrinsic component of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]
EOG8FXTPX	GO:0048477	1/290	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8FXTPX	GO:0045610	1/290	regulation of hemocyte differentiation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG8FXTPX	GO:0071902	1/290	positive regulation of protein serine/threonine kinase activity	biological_process	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]
EOG8FXTPX	GO:0007274	1/290	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8FXTPX	GO:0007419	1/290	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8FXTPX	GO:0048675	1/290	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG8FXTPX	GO:0030426	1/290	growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194]
EOG8FXTPX	GO:0007409	1/290	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8FXTPX	GO:0008078	1/290	mesodermal cell migration	biological_process	"The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047]
EOG8FXTPX	GO:0030833	1/290	regulation of actin filament polymerization	biological_process	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG8FXTPX	GO:0035318	1/290	imaginal disc-derived wing hair outgrowth	biological_process	"Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair." [GOC:mtg_sensu, PMID:11064425, PMID:8947551]
EOG8FXTPX	GO:0008582	1/290	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8FXTPX	GO:0035212	1/290	cell competition in a multicellular organism	biological_process	"Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286]
EOG8FXTPX	GO:0030424	1/290	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8FXTPX	GO:0016335	1/290	morphogenesis of larval imaginal disc epithelium	biological_process	"The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl]
EOG8FXTPX	GO:0001737	1/290	establishment of imaginal disc-derived wing hair orientation	biological_process	"Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]
EOG8FXTPX	GO:0045216	1/290	cell-cell junction organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8FXTPX	GO:0051301	1/290	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8FXTPX	GO:0007298	1/290	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8FXTPX	GO:0042052	1/290	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8FXTPX	GO:0007179	1/290	transforming growth factor beta receptor signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
EOG8FXTPX	GO:0048814	1/290	regulation of dendrite morphogenesis	biological_process	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG8FXTPX	GO:0005737	1/290	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8FXTPX	GO:0050807	1/290	regulation of synapse organization	biological_process	"Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]
EOG8FXTPX	GO:0008283	1/290	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8FXTPX	GO:0042060	1/290	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8FXTPX	GO:0007164	1/290	establishment of tissue polarity	biological_process	"Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid]
EOG8FXTPX	GO:0046664	1/290	dorsal closure, amnioserosa morphology change	biological_process	"The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138]
EOG8FXTPX	GO:0007010	1/290	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8FXTPX	GO:0007349	1/290	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG8FXTPX	GO:0005634	1/290	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG873S75	GO:0043154	2/86	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG873S75	GO:0043027	2/86	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	molecular_function	"Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]
EOG873S75	GO:0005737	2/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG873S75	GO:0035071	1/86	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG873S75	GO:0048102	1/86	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8RJJG5	GO:0005886	49/215	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8RJJG5	GO:0016021	49/215	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RJJG5	GO:0050909	49/215	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8RJJG5	GO:0003031	2/215	detection of carbon dioxide	biological_process	"The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
EOG8RJJG5	GO:0007608	2/215	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8RJJG5	GO:0050912	2/215	detection of chemical stimulus involved in sensory perception of taste	biological_process	"The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8RJJG5	GO:0010037	2/215	response to carbon dioxide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:sm]
EOG8RJJG5	GO:0008527	2/215	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8RJJG5	GO:0007610	2/215	behavior	biological_process	"The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
EOG8RJJG5	GO:0043025	1/215	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8RJJG5	GO:0030425	1/215	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8RJJG5	GO:0008340	1/215	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8DFS3D	GO:0008270	22/84	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DFS3D	GO:0019706	22/84	protein-cysteine S-palmitoyltransferase activity	molecular_function	"Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule." [EC:2.3.1.225, GOC:ai, GOC:pr]
EOG8DFS3D	GO:0016021	22/84	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DFS3D	GO:0016491	1/84	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8DFS3D	GO:0005794	1/84	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8DFS3D	GO:0018345	1/84	protein palmitoylation	biological_process	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]
EOG8GTNTX	GO:0004298	40/99	threonine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8GTNTX	GO:0005839	40/99	proteasome core complex	cellular_component	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]
EOG8GTNTX	GO:0051603	39/99	proteolysis involved in cellular protein catabolic process	biological_process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]
EOG8GTNTX	GO:0005634	39/99	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GTNTX	GO:0005737	39/99	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8GTNTX	GO:0051297	1/99	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8GTNTX	GO:0022008	1/99	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8GTNTX	GO:0000022	1/99	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8GTNTX	GO:0008283	1/99	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8GTNTX	GO:0007052	1/99	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8GTNTX	GO:0043161	1/99	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG8RJJG8	GO:0046872	5/16	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RJJG8	GO:0003676	4/16	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RJJG8	GO:0015074	1/16	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8RJJG8	GO:0003677	1/16	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RJJG8	GO:0006310	1/16	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG83XXJ1	GO:0016787	15/58	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG83XXJ1	GO:0007632	1/58	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG83XXJ1	GO:0008103	1/58	oocyte microtubule cytoskeleton polarization	biological_process	"Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042]
EOG83XXJ1	GO:0007315	1/58	pole plasm assembly	biological_process	"Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG83XXJ1	GO:0007616	1/58	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG83XXJ1	GO:0048477	1/58	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG83XXJ1	GO:0007279	1/58	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG83XXJ1	GO:0007277	1/58	pole cell development	biological_process	"The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jid]
EOG83XXJ1	GO:0043488	1/58	regulation of mRNA stability	biological_process	"Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl]
EOG83XXJ1	GO:0046011	1/58	regulation of oskar mRNA translation	biological_process	"Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512]
EOG83XXJ1	GO:0040040	1/58	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG83XXJ1	GO:0019094	1/58	pole plasm mRNA localization	biological_process	"Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
EOG83XXJ1	GO:0007359	1/58	posterior abdomen determination	biological_process	"The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG83XXJ1	GO:0008595	1/58	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG83XXJ1	GO:0043186	1/58	P granule	cellular_component	"A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
EOG83XXJ1	GO:0007281	1/58	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG83XXJ1	GO:0030719	1/58	P granule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367]
EOG83XXJ1	GO:0007314	1/58	oocyte anterior/posterior axis specification	biological_process	"Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG83XXJ1	GO:0045727	1/58	positive regulation of translation	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb]
EOG83XXJ1	GO:0007318	1/58	pole plasm protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
EOG83XXJ1	GO:0008542	1/58	visual learning	biological_process	"Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue." [GOC:jid, ISBN:0582227089]
EOG83XXJ1	GO:0045495	1/58	pole plasm	cellular_component	"Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380]
EOG83XXJ1	GO:0007275	1/58	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8HHRKW	GO:0005576	2/101	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8HHRKW	GO:0008233	2/101	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8HHRKW	GO:0005215	2/101	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8HHRKW	GO:0048190	1/101	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8HHRKW	GO:0030178	1/101	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG86HJR3	GO:0016020	26/93	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG86HJR3	GO:0005315	26/93	inorganic phosphate transmembrane transporter activity	molecular_function	"Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
EOG86HJR3	GO:0006817	25/93	phosphate ion transport	biological_process	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG86HJR3	GO:0044341	1/93	sodium-dependent phosphate transport	biological_process	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl]
EOG86HJR3	GO:0015321	1/93	sodium-dependent phosphate transmembrane transporter activity	molecular_function	"Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions." [GOC:jl]
EOG873S7G	GO:0003700	25/86	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG873S7G	GO:0043565	25/86	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG873S7G	GO:0046983	1/86	protein dimerization activity	molecular_function	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]
EOG8R7XR3	GO:0055085	46/146	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8R7XR3	GO:0016021	46/146	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG898XGP	GO:0008201	1/22	heparin binding	molecular_function	"Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]
EOG898XGP	GO:0046914	1/22	transition metal ion binding	molecular_function	"Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]
EOG847J80	GO:0000166	8/70	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG847J80	GO:0003676	7/70	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V45NQ	GO:0006457	68/221	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8V45NQ	GO:0005524	68/221	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8V45NQ	GO:0006950	67/221	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8V45NQ	GO:0005737	7/221	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8V45NQ	GO:0005811	2/221	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8V45NQ	GO:0005515	2/221	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8V45NQ	GO:0019094	1/221	pole plasm mRNA localization	biological_process	"Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
EOG8V45NQ	GO:0007283	1/221	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8V45NQ	GO:0007052	1/221	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8V45NQ	GO:0008595	1/221	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8V45NQ	GO:0048471	1/221	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8V45NQ	GO:0008293	1/221	torso signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
EOG8V45NQ	GO:0008285	1/221	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8V45NQ	GO:0009408	1/221	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8V45NQ	GO:0005615	1/221	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8V45NQ	GO:0008360	1/221	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8V45NQ	GO:0005705	1/221	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG8V45NQ	GO:0045187	1/221	regulation of circadian sleep/wake cycle, sleep	biological_process	"Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981]
EOG8V45NQ	GO:0009631	1/221	cold acclimation	biological_process	"Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr]
EOG8V45NQ	GO:0061031	1/221	endodermal digestive tract morphogenesis	biological_process	"The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm." [GOC:dph, GOC:yaf]
EOG8V45NQ	GO:0051082	1/221	unfolded protein binding	molecular_function	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]
EOG8V45NQ	GO:0048477	1/221	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8V45NQ	GO:0007015	1/221	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8V45NQ	GO:0005813	1/221	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8V45NQ	GO:0010529	1/221	negative regulation of transposition	biological_process	"Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]
EOG8V45NQ	GO:0007494	1/221	midgut development	biological_process	"The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
EOG8V45NQ	GO:0007098	1/221	centrosome cycle	biological_process	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]
EOG898XGG	GO:0006888	24/78	ER to Golgi vesicle-mediated transport	biological_process	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]
EOG898XGG	GO:0016021	24/78	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG898XGG	GO:0000139	24/78	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG898XGG	GO:0005801	24/78	cis-Golgi network	cellular_component	"The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]
EOG898XGG	GO:0015031	22/78	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG898XGG	GO:0016192	1/78	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG898XGG	GO:0000138	1/78	Golgi trans cisterna	cellular_component	"The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194]
EOG898XGG	GO:0005484	1/78	SNAP receptor activity	molecular_function	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
EOG898XGG	GO:0006891	1/78	intra-Golgi vesicle-mediated transport	biological_process	"The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]
EOG8M67XJ	GO:0006511	31/101	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8M67XJ	GO:0031461	30/101	cullin-RING ubiquitin ligase complex	cellular_component	"Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063]
EOG8M67XJ	GO:0007281	1/101	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8M67XJ	GO:0007528	1/101	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8M67XJ	GO:0008582	1/101	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8M67XJ	GO:0007293	1/101	germarium-derived egg chamber formation	biological_process	"Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8M67XJ	GO:0051726	1/101	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8M67XJ	GO:0016360	1/101	sensory organ precursor cell fate determination	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
EOG8M67XJ	GO:0007295	1/101	growth of a germarium-derived egg chamber	biological_process	"Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8M67XJ	GO:0008285	1/101	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8M67XJ	GO:0031466	1/101	Cul5-RING ubiquitin ligase complex	cellular_component	"A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]
EOG8M67XK	GO:0005198	1/50	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8M67XK	GO:0006890	1/50	retrograde vesicle-mediated transport, Golgi to ER	biological_process	"The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524]
EOG8JDKMV	GO:0008063	1/90	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8JDKMV	GO:0005121	1/90	Toll binding	molecular_function	"Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb]
EOG8JDKMV	GO:0005576	1/90	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG886BVT	GO:0007274	1/81	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG886BVT	GO:0031083	1/81	BLOC-1 complex	cellular_component	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]
EOG886BVT	GO:0005515	1/81	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG886BVT	GO:0008057	1/81	eye pigment granule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295]
EOG8SBHCW	GO:0016301	1/55	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG886BVW	GO:0005509	25/87	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG886BVW	GO:0032440	1/87	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG886BVW	GO:0007498	1/87	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG886BVW	GO:0005886	1/87	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG886BVW	GO:0005927	1/87	muscle tendon junction	cellular_component	"A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007]
EOG8SBHCD	GO:0016757	26/102	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8SBHCD	GO:0046872	1/102	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8SBHCD	GO:0003676	1/102	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG81G5MC	GO:0006850	25/97	mitochondrial pyruvate transport	biological_process	"The directed movement of pyruvate, 2-oxopropanoate, into, out of or within a mitochondrion." [GOC:ai]
EOG81G5MC	GO:0005743	24/97	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG81G5MC	GO:0006090	1/97	pyruvate metabolic process	biological_process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]
EOG81G5MC	GO:0005739	1/97	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG81G5MC	GO:0050833	1/97	pyruvate transmembrane transporter activity	molecular_function	"Enables the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other." [GOC:ai]
EOG81G5MC	GO:1901475	1/97	pyruvate transmembrane transport	biological_process	"The directed movement of pyruvate across a membrane." [GOC:TermGenie]
EOG81G5MC	GO:0031305	1/97	integral component of mitochondrial inner membrane	cellular_component	"The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
EOG85XB9M	GO:0005634	50/177	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85XB9M	GO:0003707	49/177	steroid hormone receptor activity	molecular_function	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
EOG85XB9M	GO:0008270	44/177	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG85XB9M	GO:0043565	42/177	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG85XB9M	GO:0006351	26/177	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG85XB9M	GO:0003700	26/177	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG85XB9M	GO:0004879	24/177	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	molecular_function	"Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH]
EOG85XB9M	GO:0003677	8/177	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG85XB9M	GO:0042803	2/177	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG85XB9M	GO:0030522	2/177	intracellular receptor signaling pathway	biological_process	"Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah]
EOG85XB9M	GO:0046982	2/177	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG85XB9M	GO:0005515	2/177	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG85XB9M	GO:0008289	1/177	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG85XB9M	GO:0007465	1/177	R7 cell fate commitment	biological_process	"The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883]
EOG85XB9M	GO:0048813	1/177	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG85XB9M	GO:0045892	1/177	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85XB9M	GO:0007419	1/177	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG85XB9M	GO:0071390	1/177	cellular response to ecdysone	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah]
EOG85XB9M	GO:0007510	1/177	cardioblast cell fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG85XB9M	GO:0042331	1/177	phototaxis	biological_process	"The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981]
EOG85XB9M	GO:0005500	1/177	juvenile hormone binding	molecular_function	"Interacting selectively and non-covalently with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732]
EOG85XB9M	GO:0045596	1/177	negative regulation of cell differentiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]
EOG85XB9M	GO:0001078	1/177	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
EOG85XB9M	GO:0048666	1/177	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG85XB9M	GO:0007601	1/177	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG85XB9M	GO:0035076	1/177	ecdysone receptor-mediated signaling pathway	biological_process	"The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf]
EOG85XB9M	GO:0007503	1/177	fat body development	biological_process	"The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089]
EOG85XB9M	GO:0005737	1/177	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG85XB9M	GO:0004884	1/177	ecdysteroid hormone receptor activity	molecular_function	"Combining with an ecdysteroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:1653701]
EOG85XB9M	GO:0007298	1/177	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG85XB9M	GO:0007281	1/177	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG85XB9M	GO:0040034	1/177	regulation of development, heterochronic	biological_process	"Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909]
EOG85XB9M	GO:0007464	1/177	R3/R4 cell fate commitment	biological_process	"The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
EOG85XB9M	GO:0000166	1/177	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG85XB9M	GO:0007517	1/177	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG85XB9M	GO:0061331	1/177	epithelial cell proliferation involved in Malpighian tubule morphogenesis	biological_process	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG85XB9M	GO:0008230	1/177	ecdysone receptor holocomplex	cellular_component	"A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980]
EOG85XB9M	GO:0042562	1/177	hormone binding	molecular_function	"Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
EOG85XB9M	GO:0000122	1/177	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG85XB9M	GO:0016319	1/177	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG85XB9M	GO:0007270	1/177	neuron-neuron synaptic transmission	biological_process	"The process of communication from a neuron to another neuron across a synapse." [GOC:add, GOC:jl, MeSH:D009435]
EOG85XB9M	GO:0035075	1/177	response to ecdysone	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf]
EOG85XB9M	GO:0035073	1/177	pupariation	biological_process	"The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
EOG85XB9M	GO:0007462	1/177	R1/R6 cell fate commitment	biological_process	"The process in which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
EOG85XB9M	GO:0007507	1/177	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG85XB9M	GO:0021782	1/177	glial cell development	biological_process	"The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG85XB9M	GO:0045944	1/177	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG85XB9M	GO:0046530	1/177	photoreceptor cell differentiation	biological_process	"The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732]
EOG85XB9M	GO:0030425	1/177	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG85XB9M	GO:0008232	1/177	activator ecdysone receptor complex	cellular_component	"A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes." [PMID:10488333]
EOG85XB9M	GO:0045893	1/177	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85XB9M	GO:0004872	1/177	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG85XB9M	GO:0016322	1/177	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG85XB9M	GO:0001752	1/177	compound eye photoreceptor fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
EOG85XB9M	GO:0005700	1/177	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG85XB9M	GO:0000976	1/177	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8284FJ	GO:0016020	22/160	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8284FJ	GO:0015269	22/160	calcium-activated potassium channel activity	molecular_function	"Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]
EOG8284FJ	GO:0006813	2/160	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8284FJ	GO:0005515	1/160	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8284FJ	GO:0071805	1/160	potassium ion transmembrane transport	biological_process	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
EOG8284FJ	GO:0008076	1/160	voltage-gated potassium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
EOG8284FJ	GO:0043005	1/160	neuron projection	cellular_component	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
EOG8284FJ	GO:0060072	1/160	large conductance calcium-activated potassium channel activity	molecular_function	"Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729, PMID:17115074]
EOG8284FJ	GO:0045433	1/160	male courtship behavior, veined wing generated song production	biological_process	"The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
EOG8284FJ	GO:0048512	1/160	circadian behavior	biological_process	"The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr]
EOG8284FJ	GO:0043025	1/160	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8284FJ	GO:0005249	1/160	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8284FJ	GO:0007623	1/160	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG8284FJ	GO:0005886	1/160	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8284FJ	GO:0042493	1/160	response to drug	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl]
EOG85XB9G	GO:0016772	29/60	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG85XB9T	GO:0003676	25/93	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85XB9T	GO:0003725	1/93	double-stranded RNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]
EOG8R7XRN	GO:0016021	104/311	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8R7XRN	GO:0015171	103/311	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8R7XRN	GO:0003333	3/311	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG8R7XRN	GO:0006865	1/311	amino acid transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8R7XRN	GO:0006629	1/311	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8R7XRN	GO:0015326	1/311	basic amino acid transmembrane transporter activity	molecular_function	"Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8R7XRN	GO:0000398	1/311	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8R7XRN	GO:0050829	1/311	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8R7XRN	GO:0045824	1/311	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG8R7XRN	GO:0071011	1/311	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8R7XRN	GO:0040007	1/311	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG8R7XRN	GO:0006812	1/311	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG873S76	GO:0005840	26/91	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG873S76	GO:0003735	26/91	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG873S76	GO:0006412	26/91	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG847J8V	GO:0044237	22/163	cellular metabolic process	biological_process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
EOG847J8V	GO:0006412	16/163	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG847J8V	GO:0005840	16/163	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG847J8V	GO:0003735	16/163	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG847J8V	GO:0003743	3/163	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG847J8V	GO:0005829	1/163	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG847J8V	GO:0045947	1/163	negative regulation of translational initiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG847J8V	GO:0005737	1/163	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG847J8V	GO:0005085	1/163	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG847J8V	GO:0006413	1/163	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG847J8V	GO:0005851	1/163	eukaryotic translation initiation factor 2B complex	cellular_component	"A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375]
EOG847J8V	GO:0022008	1/163	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG847J8V	GO:0006446	1/163	regulation of translational initiation	biological_process	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG847J8V	GO:0043087	1/163	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8R7XRC	GO:0005524	49/160	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8R7XRC	GO:0004674	46/160	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8R7XRC	GO:0004672	2/160	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8R7XRC	GO:0004708	2/160	MAP kinase kinase activity	molecular_function	"Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate." [ISBN:0198547684]
EOG8R7XRC	GO:0004702	2/160	receptor signaling protein serine/threonine kinase activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah]
EOG8R7XRC	GO:0048082	2/160	regulation of adult chitin-containing cuticle pigmentation	biological_process	"Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
EOG8R7XRC	GO:0006468	2/160	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8R7XRC	GO:0007257	1/160	activation of JUN kinase activity	biological_process	"The initiation of the activity of the inactive enzyme JUN kinase (JNK)." [GOC:bf]
EOG8R7XRC	GO:0040018	1/160	positive regulation of multicellular organism growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8R7XRC	GO:0023014	1/160	signal transduction by protein phosphorylation	biological_process	"A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling]
EOG8R7XRC	GO:0000187	1/160	activation of MAPK activity	biological_process	"The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267]
EOG8R7XRC	GO:0007314	1/160	oocyte anterior/posterior axis specification	biological_process	"Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8R7XRC	GO:0045793	1/160	positive regulation of cell size	biological_process	"Any process that increases cell size." [GOC:go_curators]
EOG8R7XRC	GO:0005737	1/160	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8R7XRC	GO:0007309	1/160	oocyte axis specification	biological_process	"The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8R7XRC	GO:0000165	1/160	MAPK cascade	biological_process	"An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267]
EOG8R7XRC	GO:0048666	1/160	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8R7XRC	GO:0002385	1/160	mucosal immune response	biological_process	"An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
EOG8R7XRC	GO:0048812	1/160	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8R7XRC	GO:0030424	1/160	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8R7XRC	GO:0001934	1/160	positive regulation of protein phosphorylation	biological_process	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
EOG8R7XRC	GO:0004697	1/160	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG8R7XRC	GO:0046330	1/160	positive regulation of JNK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8R7XRC	GO:0031435	1/160	mitogen-activated protein kinase kinase kinase binding	molecular_function	"Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase." [GOC:bf]
EOG8R7XRC	GO:0008545	1/160	JUN kinase kinase activity	molecular_function	"Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549]
EOG8CRPGB	GO:0004792	13/104	thiosulfate sulfurtransferase activity	molecular_function	"Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate." [EC:2.8.1.1, RHEA:16884]
EOG8CRPGB	GO:0006950	2/104	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG87SVTT	GO:0008270	1/39	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X6FQM	GO:0051920	68/238	peroxiredoxin activity	molecular_function	"Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." [EC:1.11.1.15]
EOG8X6FQM	GO:0016209	57/238	antioxidant activity	molecular_function	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
EOG8X6FQM	GO:0004601	11/238	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG8X6FQM	GO:0042744	3/238	hydrogen peroxide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]
EOG8X6FQM	GO:0008379	3/238	thioredoxin peroxidase activity	molecular_function	"Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O." [MetaCyc:RXN0-267]
EOG8X6FQM	GO:0045454	2/238	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8X6FQM	GO:0006974	2/238	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8X6FQM	GO:0005829	2/238	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8X6FQM	GO:0005515	2/238	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8X6FQM	GO:0008340	2/238	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8X6FQM	GO:0008354	1/238	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8X6FQM	GO:0005576	1/238	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8X6FQM	GO:0007281	1/238	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8X6FQM	GO:0007155	1/238	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8X6FQM	GO:0043066	1/238	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8X6FQM	GO:0005875	1/238	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8X6FQM	GO:0042594	1/238	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8X6FQM	GO:0005783	1/238	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8X6FQM	GO:0006979	1/238	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8X6FQM	GO:0006909	1/238	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8X6FQM	GO:0005739	1/238	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8X6FQM	GO:0097190	1/238	apoptotic signaling pathway	biological_process	"A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]
EOG8HMMT0	GO:0008076	53/210	voltage-gated potassium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
EOG8HMMT0	GO:0005249	52/210	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8HMMT0	GO:0051260	48/210	protein homooligomerization	biological_process	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
EOG8HMMT0	GO:0005251	2/210	delayed rectifier potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]
EOG8HMMT0	GO:0004114	2/210	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular_function	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]
EOG8HMMT0	GO:0030431	1/210	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8HMMT0	GO:0046872	1/210	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HMMT0	GO:0006813	1/210	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8HMMT0	GO:0005886	1/210	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8X6FQH	GO:0005525	26/85	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8X6FQH	GO:0007264	26/85	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8X6FQH	GO:0015031	24/85	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8X6FQH	GO:0003924	1/85	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8X6FQH	GO:0004767	1/85	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8X6FQH	GO:0006184	1/85	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8X6FQH	GO:0043025	1/85	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8X6FQH	GO:0005770	1/85	late endosome	cellular_component	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
EOG8X6FQH	GO:0045202	1/85	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG82Z75F	GO:0005634	39/99	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82Z75F	GO:0016787	3/99	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG82Z75F	GO:0006379	1/99	mRNA cleavage	biological_process	"Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah]
EOG82Z75F	GO:0005847	1/99	mRNA cleavage and polyadenylation specificity factor complex	cellular_component	"A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727]
EOG82Z75F	GO:0008270	1/99	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG82Z75F	GO:0006378	1/99	mRNA polyadenylation	biological_process	"The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]
EOG8J6V54	GO:0016787	37/138	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8J6V54	GO:0052689	2/138	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG8J6V54	GO:0003990	1/138	acetylcholinesterase activity	molecular_function	"Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
EOG8DZ4B2	GO:0006412	26/93	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8DZ4B2	GO:0005840	26/93	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8DZ4B2	GO:0003735	26/93	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8DZ4B2	GO:0007052	1/93	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8DZ4B2	GO:0000022	1/93	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8DZ4B2	GO:0051298	1/93	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8CRPGZ	GO:0003677	4/233	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CRPGZ	GO:0006351	1/233	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8CRPGZ	GO:0003899	1/233	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8CRPGZ	GO:0003676	1/233	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82Z75G	GO:0004479	18/81	methionyl-tRNA formyltransferase activity	molecular_function	"Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9]
EOG82Z75G	GO:0016742	6/81	hydroxymethyl-, formyl- and related transferase activity	molecular_function	"Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2, GOC:mah]
EOG82Z75G	GO:0009058	6/81	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG82Z75G	GO:0016021	1/81	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82Z75G	GO:0004930	1/81	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG87SVTN	GO:0000922	32/97	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG87SVTN	GO:0000226	31/97	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG87SVTN	GO:0005815	31/97	microtubule organizing center	cellular_component	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416]
EOG87SVTN	GO:0008274	1/97	gamma-tubulin ring complex	cellular_component	"A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule." [GOC:clt, PMID:12134075]
EOG87SVTN	GO:0051298	1/97	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG87SVTN	GO:0051297	1/97	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG87SVTN	GO:0045450	1/97	bicoid mRNA localization	biological_process	"Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators]
EOG87SVTN	GO:0007112	1/97	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG87SVTN	GO:0043015	1/97	gamma-tubulin binding	molecular_function	"Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin." [GOC:jl]
EOG87SVTN	GO:0005813	1/97	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG87SVTN	GO:0007067	1/97	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG87SVTN	GO:0007052	1/97	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG87SVTN	GO:0007058	1/97	spindle assembly involved in female meiosis II	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah]
EOG8DZ4B8	GO:0008270	45/102	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DZ4B8	GO:0016874	2/102	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8DZ4B8	GO:0016322	1/102	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG8DZ4B8	GO:0016567	1/102	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8DZ4B8	GO:0005737	1/102	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8DZ4B8	GO:0007224	1/102	smoothened signaling pathway	biological_process	"A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
EOG8DZ4B8	GO:0008283	1/102	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8DZ4B8	GO:0005634	1/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8DZ4B8	GO:0004842	1/102	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8DZ4B8	GO:0019005	1/102	SCF ubiquitin ligase complex	cellular_component	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
EOG8DZ4B8	GO:0022008	1/102	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8DZ4B8	GO:0019915	1/102	lipid storage	biological_process	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]
EOG8DZ4B8	GO:0030178	1/102	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8DZ4B8	GO:0006508	1/102	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8GB9M8	GO:0016192	24/97	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8GB9M8	GO:0006886	24/97	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8GB9M8	GO:0030131	23/97	clathrin adaptor complex	cellular_component	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]
EOG8GB9M8	GO:0005802	2/97	trans-Golgi network	cellular_component	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]
EOG8GB9M8	GO:0048471	1/97	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8GB9M8	GO:0005737	1/97	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8GB9M8	GO:0032050	1/97	clathrin heavy chain binding	molecular_function	"Interacting selectively and non-covalently with a clathrin heavy chain." [GOC:mah]
EOG8GB9M8	GO:0008565	1/97	protein transporter activity	molecular_function	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
EOG8GB9M8	GO:0005829	1/97	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8GB9M8	GO:0005515	1/97	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8GB9M8	GO:0030136	1/97	clathrin-coated vesicle	cellular_component	"A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]
EOG8GB9M8	GO:0006892	1/97	post-Golgi vesicle-mediated transport	biological_process	"The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah]
EOG8N334P	GO:0045596	5/97	negative regulation of cell differentiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]
EOG8N334P	GO:0008293	2/97	torso signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
EOG8N334P	GO:0005576	1/97	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8N334P	GO:0005122	1/97	torso binding	molecular_function	"Interacting selectively and non-covalently with the torso (tor) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:2927509]
EOG8N334P	GO:0018445	1/97	prothoracicotrophic hormone activity	molecular_function	"The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects." [GOC:mah, PMID:3301403]
EOG8N334P	GO:0008595	1/97	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8N334P	GO:0008358	1/97	maternal determination of anterior/posterior axis, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8N334P	GO:0007362	1/97	terminal region determination	biological_process	"Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8N334P	GO:0046957	1/97	negative phototaxis	biological_process	"The directed movement of a cell or organism away from a source of light." [GOC:ai]
EOG8N334P	GO:0043196	1/97	varicosity	cellular_component	"Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln]
EOG8N334P	GO:0007552	1/97	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG8N334P	GO:0044060	1/97	regulation of endocrine process	biological_process	"Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [GOC:jl]
EOG8N334P	GO:0005179	1/97	hormone activity	molecular_function	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]
EOG8GB9M4	GO:0016021	7/105	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XSP61	GO:0003676	3/275	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XSP61	GO:0003677	2/275	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XSP61	GO:0015074	2/275	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8XSP61	GO:0003887	1/275	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8XSP61	GO:0000166	1/275	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8HDW9M	GO:0015991	26/84	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8HDW9M	GO:0046961	26/84	proton-transporting ATPase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]
EOG8HDW9M	GO:0033180	25/84	proton-transporting V-type ATPase, V1 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG8HDW9M	GO:0033181	1/84	plasma membrane proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
EOG8HDW9M	GO:0005886	1/84	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8HDW9M	GO:0000221	1/84	vacuolar proton-transporting V-type ATPase, V1 domain	cellular_component	"The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG8ZCWMT	GO:0008137	37/99	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8ZCWMT	GO:0042773	37/99	ATP synthesis coupled electron transport	biological_process	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363]
EOG8ZCWMT	GO:0005743	37/99	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8C2KS3	GO:0015986	37/111	ATP synthesis coupled proton transport	biological_process	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]
EOG8C2KS3	GO:0000276	37/111	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	cellular_component	"All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056]
EOG8C2KS3	GO:0015078	36/111	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG8C2KS3	GO:0016787	2/111	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8C2KS3	GO:0006909	1/111	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8C2KS3	GO:0046933	1/111	proton-transporting ATP synthase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]
EOG8C2KS3	GO:0005811	1/111	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8ZCWMQ	GO:0000723	130/891	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8ZCWMQ	GO:0006281	130/891	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8ZCWMQ	GO:0003678	130/891	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8ZCWMQ	GO:0005524	46/891	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZCWMQ	GO:0004386	20/891	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8ZCWMQ	GO:0003676	5/891	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZCWMQ	GO:0005634	2/891	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZCWMQ	GO:0003677	2/891	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8ZCWMQ	GO:0008234	1/891	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8ZCWMQ	GO:0006508	1/891	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8ZCWMQ	GO:0008270	1/891	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZCWMQ	GO:0046872	1/891	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GB9MZ	GO:0050660	281/974	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8GB9MZ	GO:0008812	249/974	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG8GB9MZ	GO:0006066	249/974	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG8GB9MZ	GO:0016614	32/974	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8GB9MZ	GO:0004198	12/974	calcium-dependent cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]
EOG8GB9MZ	GO:0005622	12/974	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8GB9MZ	GO:0004344	11/974	glucose dehydrogenase activity	molecular_function	"Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10]
EOG8GB9MZ	GO:0005509	10/974	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8GB9MZ	GO:0016491	9/974	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8GB9MZ	GO:0045455	9/974	ecdysteroid metabolic process	biological_process	"The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732]
EOG8GB9MZ	GO:0008270	1/974	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GB9MZ	GO:0006915	1/974	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8GB9MZ	GO:0042600	1/974	chorion	cellular_component	"A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
EOG8GB9MZ	GO:0004190	1/974	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8GB9MZ	GO:0003676	1/974	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GB9MZ	GO:0004197	1/974	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8GB9MZ	GO:0046331	1/974	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8GB9MZ	GO:0015074	1/974	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8GB9MV	GO:0005337	31/96	nucleoside transmembrane transporter activity	molecular_function	"Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai]
EOG8GB9MV	GO:0016021	31/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GB9MV	GO:0007268	1/96	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8GB9MV	GO:0008306	1/96	associative learning	biological_process	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
EOG8GB9MV	GO:0005886	1/96	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8GB9MV	GO:0090281	1/96	negative regulation of calcium ion import	biological_process	"Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF]
EOG8GF5WN	GO:0016021	29/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GF5WN	GO:0008565	29/96	protein transporter activity	molecular_function	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
EOG8SXQVH	GO:0016021	8/54	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SXQVH	GO:0004930	8/54	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8SXQVH	GO:0007218	1/54	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8SXQVH	GO:0050254	1/54	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG82Z754	GO:0008080	23/81	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG82Z754	GO:0007059	1/81	chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
EOG82Z754	GO:0010485	1/81	H4 histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4." [EC:2.3.1.48]
EOG82Z754	GO:0004596	1/81	peptide alpha-N-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [EC:2.3.1.88, GOC:mah]
EOG82Z754	GO:0017196	1/81	N-terminal peptidyl-methionine acetylation	biological_process	"The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049]
EOG82Z754	GO:0005737	1/81	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82Z754	GO:0004402	1/81	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG82Z754	GO:0043967	1/81	histone H4 acetylation	biological_process	"The modification of histone H4 by the addition of an acetyl group." [GOC:jl]
EOG8SXQVF	GO:0010181	21/88	FMN binding	molecular_function	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]
EOG8SXQVF	GO:0016491	21/88	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8SXQVF	GO:0004842	1/88	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8SXQVF	GO:0008134	1/88	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8SXQVF	GO:0006749	1/88	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG8SXQVF	GO:0071797	1/88	LUBAC complex	cellular_component	"A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex." [GOC:sp, PMID:17006537, PMID:19136968, PMID:21455180]
EOG8SXQVF	GO:0003840	1/88	gamma-glutamyltransferase activity	molecular_function	"Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2]
EOG8DZ4BK	GO:0000166	32/91	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8DZ4BK	GO:0003676	30/91	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DZ4BK	GO:0003729	2/91	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8X6FQ4	GO:0008355	1/83	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8X6FQ4	GO:0071011	1/83	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8X6FQ4	GO:0000398	1/83	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8X6FQ4	GO:0071013	1/83	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8CJZ0B	GO:0016020	1/22	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CJZ0B	GO:0005024	1/22	transforming growth factor beta-activated receptor activity	molecular_function	"Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]
EOG88D3C5	GO:0016021	2/13	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8P2SHG	GO:0000123	25/100	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG8P2SHG	GO:0005634	1/100	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8P2SHG	GO:0007095	1/100	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8P2SHG	GO:0004427	1/100	inorganic diphosphatase activity	molecular_function	"Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate." [EC:3.6.1.1, RHEA:24579]
EOG8P2SHG	GO:0022008	1/100	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8P2SHG	GO:0044545	1/100	NSL complex	cellular_component	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852]
EOG8KPWT0	GO:0010826	24/79	negative regulation of centrosome duplication	biological_process	"Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]
EOG8KPWT0	GO:0042384	24/79	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8KPWT0	GO:0036038	24/79	TCTN-B9D complex	cellular_component	"A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins." [GOC:sp, PMID:21725307, PMID:22179047]
EOG8KPWT0	GO:0051726	1/79	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG85QKTM	GO:0004356	51/151	glutamate-ammonia ligase activity	molecular_function	"Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.2, RHEA:16172]
EOG85QKTM	GO:0006542	49/151	glutamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
EOG85QKTM	GO:0005524	44/151	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG85QKTM	GO:0006807	2/151	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG85QKTM	GO:0006541	1/151	glutamine metabolic process	biological_process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
EOG85QKTM	GO:0006538	1/151	glutamate catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
EOG85QKTM	GO:0007005	1/151	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG85QKTM	GO:0005737	1/151	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG85QKTM	GO:0045213	1/151	neurotransmitter receptor metabolic process	biological_process	"The chemical reactions and pathways involving neurotransmitter receptors." [GOC:go_curators]
EOG85QKTM	GO:0005811	1/151	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG85QKTM	GO:0005739	1/151	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG85QKTM	GO:0007416	1/151	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG8KM1H8	GO:0046872	1/17	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85QKTZ	GO:0005634	24/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85QKTZ	GO:0043565	23/84	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG85QKTZ	GO:0003700	23/84	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG85QKTZ	GO:0045944	1/84	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG85QKTZ	GO:0007507	1/84	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG85QKTZ	GO:0007522	1/84	visceral muscle development	biological_process	"The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators]
EOG85QKTZ	GO:0000976	1/84	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG85QKTZ	GO:0001710	1/84	mesodermal cell fate commitment	biological_process	"The cell differentiation process that results in commitment of a cell to become part of the mesoderm." [GOC:go_curators, ISBN:0878932437]
EOG85QKTZ	GO:0003677	1/84	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG85QKTZ	GO:0007501	1/84	mesodermal cell fate specification	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
EOG85QKTZ	GO:0007494	1/84	midgut development	biological_process	"The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
EOG85QKTZ	GO:0003705	1/84	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG85QKTZ	GO:0006366	1/84	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG85QKTZ	GO:0006357	1/84	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG85QKTZ	GO:0004000	1/84	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG85QKTZ	GO:0007498	1/84	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG83BQ33	GO:0004177	167/275	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG83BQ33	GO:0005737	163/275	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83BQ33	GO:0030145	163/275	manganese ion binding	molecular_function	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
EOG83BQ33	GO:0008235	163/275	metalloexopeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]
EOG83BQ33	GO:0005622	4/275	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG83BQ33	GO:0005615	1/275	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG83BQ33	GO:0003676	1/275	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83BQ33	GO:0032504	1/275	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG83BQ33	GO:0016319	1/275	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG83BQ33	GO:0016706	1/275	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG83BQ33	GO:0007498	1/275	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG83BQ33	GO:0015074	1/275	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG85QKT4	GO:0005319	22/91	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG85QKT4	GO:0042157	1/91	lipoprotein metabolic process	biological_process	"The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732]
EOG85QKT4	GO:0015914	1/91	phospholipid transport	biological_process	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]
EOG85QKT4	GO:0035149	1/91	lumen formation, open tracheal system	biological_process	"Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
EOG85QKT4	GO:0048813	1/91	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG85QKT4	GO:0008525	1/91	phosphatidylcholine transporter activity	molecular_function	"Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732]
EOG85QKT4	GO:0005811	1/91	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG85QKT4	GO:0008039	1/91	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8MGVQB	GO:0005615	1/22	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8KM1HQ	GO:0003743	25/88	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8KM1HQ	GO:0022008	1/88	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8KM1HQ	GO:0006413	1/88	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG8KM1HQ	GO:0005525	1/88	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8KM1HQ	GO:0005829	1/88	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8HDW9D	GO:0008362	1/102	chitin-based embryonic cuticle biosynthetic process	biological_process	"Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232]
EOG8HDW9D	GO:0045177	1/102	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8HDW9D	GO:0008039	1/102	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8HDW9D	GO:0007475	1/102	apposition of dorsal and ventral imaginal disc-derived wing surfaces	biological_process	"The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu]
EOG8HDW9D	GO:0040005	1/102	chitin-based cuticle attachment to epithelium	biological_process	"Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8KM1HT	GO:0006096	47/135	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8KM1HT	GO:0004739	47/135	pyruvate dehydrogenase (acetyl-transferring) activity	molecular_function	"Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1]
EOG8KM1HT	GO:0043231	46/135	intracellular membrane-bounded organelle	cellular_component	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
EOG8KM1HT	GO:0016624	3/135	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]
EOG8KM1HT	GO:0005739	1/135	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG88D3CN	GO:0003676	8/343	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88D3CN	GO:0008270	6/343	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG88D3CN	GO:0004190	5/343	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG88D3CN	GO:0015074	2/343	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG88D3CN	GO:0003677	1/343	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG88D3CN	GO:0006351	1/343	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG88D3CN	GO:0005634	1/343	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88D3CN	GO:0003964	1/343	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG88D3CN	GO:0003723	1/343	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG87DCZV	GO:0006919	6/32	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
EOG87DCZV	GO:0005739	6/32	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG87DCZV	GO:0005840	1/32	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG87DCZN	GO:0005328	1/14	neurotransmitter:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
EOG87DCZN	GO:0016021	1/14	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JQ6BG	GO:0016021	23/284	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JQ6BG	GO:0005216	21/284	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8JQ6BG	GO:0005249	4/284	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8JQ6BG	GO:0006812	2/284	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8JQ6BG	GO:0004692	2/284	cGMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
EOG8JQ6BG	GO:0005887	2/284	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JQ6BG	GO:0019935	2/284	cyclic-nucleotide-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
EOG8JQ6BG	GO:0042391	2/284	regulation of membrane potential	biological_process	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
EOG8JQ6BG	GO:0005221	2/284	intracellular cyclic nucleotide activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG8JQ6BG	GO:0071805	2/284	potassium ion transmembrane transport	biological_process	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
EOG8JQ6BG	GO:0017071	2/284	intracellular cyclic nucleotide activated cation channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah]
EOG8JQ6BG	GO:0005223	1/284	intracellular cGMP activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG8JQ6BG	GO:0005222	1/284	intracellular cAMP activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG8JQ6BG	GO:0030553	1/284	cGMP binding	molecular_function	"Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai]
EOG8JQ6BG	GO:0007603	1/284	phototransduction, visible light	biological_process	"The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
EOG8JQ6BK	GO:0003824	242/458	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8JQ6BK	GO:0032504	4/458	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8JQ6BK	GO:0005615	3/458	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8JQ6BK	GO:0055085	2/458	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8JQ6BK	GO:0016021	2/458	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8909SF	GO:0003700	2/13	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8909SF	GO:0005634	2/13	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FXTNJ	GO:0046856	12/78	phosphatidylinositol dephosphorylation	biological_process	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]
EOG8FXTNJ	GO:0004439	2/78	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36, RHEA:22767]
EOG8FXTNJ	GO:0046030	1/78	inositol trisphosphate phosphatase activity	molecular_function	"Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate." [GOC:bf]
EOG8FXTNJ	GO:0016311	1/78	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG8K9DTF	GO:0043565	33/151	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8K9DTF	GO:0008270	33/151	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8K9DTF	GO:0005634	33/151	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8K9DTF	GO:0003700	33/151	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8K9DTF	GO:0006355	1/151	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8K9DTF	GO:0048749	1/151	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8K9DTF	GO:0007444	1/151	imaginal disc development	biological_process	"The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238]
EOG8K9DTF	GO:0006351	1/151	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8K9DTF	GO:0010468	1/151	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8K9DTC	GO:0003824	2/7	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8K9DTC	GO:0030170	2/7	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8FXTND	GO:0046872	5/104	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8FXTND	GO:0004842	1/104	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8FXTND	GO:0000151	1/104	ubiquitin ligase complex	cellular_component	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
EOG8XSP6B	GO:0003676	57/550	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XSP6B	GO:0008270	55/550	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XSP6B	GO:0003723	11/550	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8XSP6B	GO:0003964	11/550	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8XSP6B	GO:0004190	5/550	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8XSP6B	GO:0005882	4/550	intermediate filament	cellular_component	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
EOG8XSP6B	GO:0005198	4/550	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8XSP6B	GO:0006355	1/550	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8XSP6B	GO:0016787	1/550	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8XSP6B	GO:0015074	1/550	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8XSP6B	GO:0005634	1/550	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88KTT6	GO:0016787	2/83	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG88KTT6	GO:0006629	2/83	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG88KTT6	GO:0005576	2/83	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG88KTT6	GO:0048812	1/83	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8TXF6D	GO:0006807	29/98	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG8TXF6D	GO:0016810	27/98	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
EOG8TXF6D	GO:0003837	3/98	beta-ureidopropionase activity	molecular_function	"Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6]
EOG8TXF6D	GO:0006208	1/98	pyrimidine nucleobase catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [CHEBI:26432, GOC:go_curators]
EOG8TXF6D	GO:0006207	1/98	'de novo' pyrimidine nucleobase biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]
EOG8BZQJ4	GO:0016787	1/83	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8DZ49Z	GO:0003676	6/41	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BZQJC	GO:0016021	21/71	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BZQJC	GO:0005524	1/71	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8BZQJC	GO:0015416	1/71	organic phosphonate transmembrane-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:3.6.3.28]
EOG8BZQJC	GO:0005829	1/71	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8F4VSZ	GO:0045454	14/94	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG85F05D	GO:0004364	32/318	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG85F05D	GO:0016740	19/318	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG85F05D	GO:0004667	6/318	prostaglandin-D synthase activity	molecular_function	"Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2)." [EC:5.3.99.2, RHEA:10603]
EOG85F05D	GO:0008152	1/318	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG85F05D	GO:0006749	1/318	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG85F05D	GO:0055114	1/318	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG85F05D	GO:0004602	1/318	glutathione peroxidase activity	molecular_function	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9]
EOG8DZ49F	GO:0015018	29/89	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135]
EOG8DZ49F	GO:0016020	28/89	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8DZ49F	GO:0015020	1/89	glucuronosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17]
EOG8DZ49F	GO:0046872	1/89	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DZ49F	GO:0006486	1/89	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8DZ49F	GO:0030206	1/89	chondroitin sulfate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732]
EOG8DZ49F	GO:0000139	1/89	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8DZ49F	GO:0015012	1/89	heparan sulfate proteoglycan biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210]
EOG8DZ49F	GO:0030166	1/89	proteoglycan biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]
EOG8DZ49F	GO:0016021	1/89	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C2KSF	GO:0008137	1/80	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8C2KSF	GO:0003954	1/80	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8PCD8W	GO:0005576	1/82	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8PCD8W	GO:0019991	1/82	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG8PCD8W	GO:0046658	1/82	anchored component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG8PCD8W	GO:0035152	1/82	regulation of tube architecture, open tracheal system	biological_process	"Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584]
EOG8K9DT5	GO:0008033	26/77	tRNA processing	biological_process	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]
EOG8K9DT5	GO:0004540	26/77	ribonuclease activity	molecular_function	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]
EOG8K9DT5	GO:0004497	1/77	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8K9DT5	GO:0005506	1/77	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8K9DT5	GO:0030677	1/77	ribonuclease P complex	cellular_component	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]
EOG8K9DT5	GO:0022008	1/77	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8K9DT5	GO:0016705	1/77	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8K9DT5	GO:0020037	1/77	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8GXJ45	GO:0016301	1/58	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8GXJ45	GO:0080019	1/58	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8Q5C4Z	GO:0008270	29/245	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q5C4Z	GO:0003676	26/245	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q5C4Z	GO:0003964	4/245	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8Q5C4Z	GO:0003723	4/245	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8G4K4R	GO:0016534	28/115	cyclin-dependent protein kinase 5 activator activity	molecular_function	"Binds to and increases the activity of cyclin-dependent protein kinase 5." [GOC:mah]
EOG8G4K4R	GO:0016533	28/115	cyclin-dependent protein kinase 5 holoenzyme complex	cellular_component	"A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits." [PMID:15689152]
EOG8G4K4R	GO:0016301	6/115	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8G4K4R	GO:0007409	1/115	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8G4K4R	GO:0004693	1/115	cyclin-dependent protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]
EOG8G4K4R	GO:0043025	1/115	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8G4K4R	GO:0035011	1/115	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG8G4K4R	GO:0030426	1/115	growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194]
EOG8G4K4R	GO:0030424	1/115	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8G4K4R	GO:0030425	1/115	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8G4K4R	GO:0070059	1/115	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	biological_process	"A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708]
EOG8G4K4R	GO:0008045	1/115	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8G4K4R	GO:0008344	1/115	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG8G4K4R	GO:0071902	1/115	positive regulation of protein serine/threonine kinase activity	biological_process	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]
EOG8G4K4R	GO:0008340	1/115	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG85HVC6	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VX4M3	GO:0022008	1/82	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8VX4M3	GO:0004462	1/82	lactoylglutathione lyase activity	molecular_function	"Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19072]
EOG8VX4M3	GO:0016829	1/82	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8VX4M0	GO:0008270	76/1021	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VX4M0	GO:0003676	72/1021	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VX4M0	GO:0003964	70/1021	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8VX4M0	GO:0015074	70/1021	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8VX4M0	GO:0003723	69/1021	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8VX4M0	GO:0005198	14/1021	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8VX4M0	GO:0005882	14/1021	intermediate filament	cellular_component	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
EOG8VX4M0	GO:0004190	10/1021	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8VX4M0	GO:0003677	4/1021	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8VX4M0	GO:0005634	2/1021	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Q5C4N	GO:0016021	25/100	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Q5C4N	GO:0015385	24/100	sodium:proton antiporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-]
EOG8Q5C4N	GO:0006885	24/100	regulation of pH	biological_process	"Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8Q5C4N	GO:0015299	1/100	solute:proton antiporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]
EOG8Q5C4N	GO:0048471	1/100	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG88SK91	GO:0016226	22/78	iron-sulfur cluster assembly	biological_process	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]
EOG88SK91	GO:0005506	22/78	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG88SK91	GO:0051536	22/78	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG87M4DJ	GO:0005198	11/55	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8Q5C4D	GO:0016787	28/88	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8Q5C4D	GO:0046872	1/88	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8R7XSQ	GO:0008473	1/48	ornithine cyclodeaminase activity	molecular_function	"Catalysis of the reaction: L-ornithine = L-proline + NH(4)(+)." [EC:4.3.1.12, RHEA:24371]
EOG8VQD3T	GO:0016758	24/79	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8VQD3T	GO:0005789	24/79	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8VQD3T	GO:0006486	1/79	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8VQD3T	GO:0016021	1/79	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZPH92	GO:0004775	39/108	succinate-CoA ligase (ADP-forming) activity	molecular_function	"Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [EC:6.2.1.5]
EOG8ZPH92	GO:0003878	39/108	ATP citrate synthase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA." [EC:2.3.3.8, RHEA:21163]
EOG8ZPH92	GO:0048037	38/108	cofactor binding	molecular_function	"Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]
EOG8ZPH92	GO:0004776	4/108	succinate-CoA ligase (GDP-forming) activity	molecular_function	"Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate." [EC:6.2.1.4]
EOG8ZPH92	GO:0006099	1/108	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8ZPH92	GO:0016020	1/108	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8ZPH92	GO:0005739	1/108	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8ZPH92	GO:0005525	1/108	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8ZPH92	GO:0046331	1/108	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8ZPH92	GO:0022008	1/108	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8F7R03	GO:0000166	26/124	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8F7R03	GO:0005634	24/124	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8F7R03	GO:0003723	23/124	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8F7R03	GO:0006397	23/124	mRNA processing	biological_process	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]
EOG8F7R03	GO:0003676	2/124	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8F7R03	GO:0032440	2/124	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8F7R03	GO:0008587	1/124	imaginal disc-derived wing margin morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG8F7R03	GO:0007319	1/124	negative regulation of oskar mRNA translation	biological_process	"Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems]
EOG8F7R03	GO:0008103	1/124	oocyte microtubule cytoskeleton polarization	biological_process	"Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042]
EOG8F7R03	GO:0003729	1/124	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8F7R03	GO:0007291	1/124	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8F7R03	GO:0006974	1/124	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8F7R03	GO:0007286	1/124	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG8F7R03	GO:0030529	1/124	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8F7R03	GO:0003730	1/124	mRNA 3'-UTR binding	molecular_function	"Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah]
EOG8F7R03	GO:0008187	1/124	poly-pyrimidine tract binding	molecular_function	"Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule." [GOC:jl]
EOG8F7R03	GO:0008586	1/124	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG8F7R03	GO:0005737	1/124	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8F7R03	GO:2001020	1/124	regulation of response to DNA damage stimulus	biological_process	"Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
EOG8F7R03	GO:0000900	1/124	translation repressor activity, nucleic acid binding	molecular_function	"Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw]
EOG8F7R03	GO:0000398	1/124	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG847J9W	GO:0043565	5/19	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG847J9W	GO:0005634	5/19	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8F7R00	GO:0016021	23/89	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F7R00	GO:0005886	15/89	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8F7R00	GO:0048477	15/89	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8F7R00	GO:0007283	15/89	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8F7R00	GO:0044332	1/89	Wnt signaling pathway involved in dorsal/ventral axis specification	biological_process	"The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the establishment, maintenance and elaboration of the dorsal/ventral axis." [GOC:jl, GOC:yaf]
EOG8F7R00	GO:0042813	1/89	Wnt-activated receptor activity	molecular_function	"Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators]
EOG8F7R00	GO:0007285	1/89	primary spermatocyte growth	biological_process	"The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jid, ISBN:0879694238]
EOG8F7R00	GO:0060070	1/89	canonical Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488]
EOG8F7R00	GO:0017147	1/89	Wnt-protein binding	molecular_function	"Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]
EOG8F7R09	GO:0002028	2/137	regulation of sodium ion transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph]
EOG8F7R09	GO:0017080	2/137	sodium channel regulator activity	molecular_function	"Modulates the activity of a sodium channel." [GOC:mah]
EOG8F7R09	GO:0016021	2/137	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZPH9G	GO:0019901	1/73	protein kinase binding	molecular_function	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]
EOG8ZPH9G	GO:0046872	1/73	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8R7XS5	GO:0005509	27/91	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8R7XS5	GO:0016174	1/91	NAD(P)H oxidase activity	molecular_function	"Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide." [EC:1.6.3.1]
EOG8ZPH9P	GO:0016021	24/82	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZPH9P	GO:0016560	24/82	protein import into peroxisome matrix, docking	biological_process	"The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane." [PMID:11687502, PMID:11988772, PMID:14754507]
EOG8ZPH9P	GO:0005777	24/82	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8ZPH9P	GO:0048137	1/82	spermatocyte division	biological_process	"The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238]
EOG8ZPH9P	GO:0007031	1/82	peroxisome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
EOG8ZPH9W	GO:0005524	2/20	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZPH9W	GO:0016887	2/20	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8BGC8T	GO:0005975	2/213	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8BGC8T	GO:0004553	2/213	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8BGC8T	GO:0007300	1/213	ovarian nurse cell to oocyte transport	biological_process	"Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8BGC8T	GO:0035324	1/213	female germline ring canal	cellular_component	"An intercellular bridge that connects the germline cells of a female cyst." [PMID:9635420]
EOG8BGC8T	GO:0030717	1/213	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG8BGC8T	GO:0005737	1/213	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8BGC8T	GO:0030036	1/213	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8BGC8T	GO:0007297	1/213	ovarian follicle cell migration	biological_process	"The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8BGC8T	GO:0035183	1/213	female germline ring canal inner rim	cellular_component	"A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins." [PMID:10556087, PMID:7925006, PMID:9093858]
EOG8BGC8T	GO:0003779	1/213	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8BGC8T	GO:0030723	1/213	ovarian fusome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]
EOG8BGC8T	GO:0005856	1/213	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8BGC8T	GO:0048477	1/213	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8BGC8T	GO:0007349	1/213	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG8BGC8T	GO:0045172	1/213	germline ring canal	cellular_component	"Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801]
EOG8BGC8T	GO:0007301	1/213	female germline ring canal formation	biological_process	"Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238]
EOG8VX4MX	GO:0006183	26/82	GTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8VX4MX	GO:0005524	26/82	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VX4MX	GO:0006228	26/82	UTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732]
EOG8VX4MX	GO:0004550	26/82	nucleoside diphosphate kinase activity	molecular_function	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]
EOG8VX4MX	GO:0006241	26/82	CTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]
EOG85HVCW	GO:0003723	1/25	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG85HVCW	GO:0003964	1/25	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG85HVCW	GO:0008270	1/25	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q5C47	GO:0003964	34/377	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8Q5C47	GO:0003723	27/377	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8Q5C47	GO:0046872	14/377	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Q5C47	GO:0003677	7/377	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Q5C47	GO:0008270	3/377	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q5C47	GO:0003676	2/377	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q5C47	GO:0006355	2/377	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Q5C47	GO:0004519	1/377	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG85HVCR	GO:0004252	60/114	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG85HVCR	GO:0006508	2/114	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG85HVCR	GO:0006281	1/114	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG85HVCR	GO:0005634	1/114	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VX4MN	GO:0003682	4/48	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG81G5J6	GO:0008233	1/86	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8VX4MK	GO:0003743	28/84	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8VX4MK	GO:0004089	1/84	carbonate dehydratase activity	molecular_function	"Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1]
EOG8RJJFT	GO:0016021	16/63	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RJJFT	GO:0022891	15/63	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8RJJFT	GO:0008643	5/63	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8RJJFT	GO:0003964	1/63	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8RJJFT	GO:0046872	1/63	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RJJFT	GO:0003723	1/63	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RJJFT	GO:0022857	1/63	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG85HVCG	GO:0003676	24/78	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85HVCG	GO:0008168	24/78	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8WDGTG	GO:0006974	1/83	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8WDGTK	GO:0005198	5/216	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8WDGTK	GO:0019028	5/216	viral capsid	cellular_component	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
EOG8WDGTH	GO:0042302	31/105	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8WDGTH	GO:0031012	1/105	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8WDGTH	GO:0008010	1/105	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8WDGTH	GO:0040003	1/105	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8XPSXS	GO:0006457	31/96	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8XPSXS	GO:0000774	31/96	adenyl-nucleotide exchange factor activity	molecular_function	"Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd]
EOG8XPSXS	GO:0005759	28/96	mitochondrial matrix	cellular_component	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]
EOG8XPSXS	GO:0016853	1/96	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8XPSXS	GO:0004750	1/96	ribulose-phosphate 3-epimerase activity	molecular_function	"Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.1, RHEA:13680]
EOG8XPSXS	GO:0022008	1/96	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8C2KRT	GO:0003993	96/479	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG8C2KRT	GO:0006909	1/479	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG81K1T5	GO:0051287	73/226	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG81K1T5	GO:0016616	67/226	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG81K1T5	GO:0030267	4/226	glyoxylate reductase (NADP) activity	molecular_function	"Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [EC:1.1.1.79]
EOG81K1T5	GO:0047964	2/226	glyoxylate reductase activity	molecular_function	"Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH." [EC:1.1.1.26, MetaCyc:GLYCOLATE-REDUCTASE-RXN]
EOG81K1T5	GO:0004617	1/226	phosphoglycerate dehydrogenase activity	molecular_function	"Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95]
EOG81K1T5	GO:0005576	1/226	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG81K1T5	GO:0048037	1/226	cofactor binding	molecular_function	"Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]
EOG81K1T5	GO:0003676	1/226	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NS5SQ	GO:0030414	2/5	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8NS5SQ	GO:0008233	1/5	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG880MBX	GO:0046872	3/27	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG880MBV	GO:0016772	28/93	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG880MBV	GO:0004305	3/93	ethanolamine kinase activity	molecular_function	"Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine." [EC:2.7.1.82, RHEA:13072]
EOG880MBV	GO:0016319	1/93	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG880MBV	GO:0008306	1/93	associative learning	biological_process	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
EOG880MBV	GO:0007420	1/93	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG880MBV	GO:0016301	1/93	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG880MBV	GO:0046337	1/93	phosphatidylethanolamine metabolic process	biological_process	"The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [CHEBI:16038, GOC:curators, ISBN:0198506732]
EOG880MBV	GO:0046959	1/93	habituation	biological_process	"A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089]
EOG880MBV	GO:0007616	1/93	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG880MBV	GO:0009612	1/93	response to mechanical stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]
EOG880MBV	GO:0001666	1/93	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG880MBV	GO:0004103	1/93	choline kinase activity	molecular_function	"Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+)." [EC:2.7.1.32, RHEA:12840]
EOG880MBV	GO:0005524	1/93	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG880MBV	GO:0055059	1/93	asymmetric neuroblast division	biological_process	"The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
EOG880MBV	GO:0016310	1/93	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG880MBV	GO:0006646	1/93	phosphatidylethanolamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732]
EOG880MBV	GO:0007638	1/93	mechanosensory behavior	biological_process	"Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators]
EOG880MBV	GO:0005737	1/93	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG880MBV	GO:0006657	1/93	CDP-choline pathway	biological_process	"The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [ISBN:0471331309, MetaCyc:PWY3O-450]
EOG81K1T9	GO:0003677	16/116	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81K1T9	GO:0006355	10/116	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG81K1T9	GO:0006351	9/116	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG81K1T9	GO:0051493	9/116	regulation of cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
EOG81K1T9	GO:0007366	9/116	periodic partitioning by pair rule gene	biological_process	"Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG81K1T9	GO:0032368	9/116	regulation of lipid transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG81K1T9	GO:0008361	9/116	regulation of cell size	biological_process	"Any process that modulates the size of a cell." [GOC:go_curators]
EOG81K1T9	GO:0042051	9/116	compound eye photoreceptor development	biological_process	"The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
EOG81K1T9	GO:0003700	9/116	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG81K1T9	GO:0005634	9/116	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81K1T9	GO:0007365	1/116	periodic partitioning	biological_process	"The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma]
EOG81K1T9	GO:0007611	1/116	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG81K1T9	GO:0048190	1/116	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG81K1T9	GO:0000915	1/116	actomyosin contractile ring assembly	biological_process	"The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
EOG81K1T9	GO:0032783	1/116	ELL-EAF complex	cellular_component	"A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae." [PMID:17150956]
EOG81K1T9	GO:0007379	1/116	segment specification	biological_process	"The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG81K1T9	GO:0042048	1/116	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG880MBM	GO:0006869	2/90	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG880MBM	GO:0016740	1/90	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG880MBC	GO:0055085	30/107	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG880MBC	GO:0005215	30/107	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG880MBC	GO:0016021	29/107	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG880MBC	GO:0016020	1/107	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG81K1TV	GO:0015918	4/343	sterol transport	biological_process	"The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]
EOG81K1TV	GO:0001530	1/343	lipopolysaccharide binding	molecular_function	"Interacting selectively and non-covalently with lipopolysaccharide." [PMID:11079463]
EOG81K1TV	GO:0030882	1/343	lipid antigen binding	molecular_function	"Interacting selectively and non-covalently with a lipid antigen." [PMID:14500461]
EOG81K1TV	GO:0008270	1/343	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81K1TV	GO:0022008	1/343	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG81K1TV	GO:0005615	1/343	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG81K1TV	GO:0070891	1/343	lipoteichoic acid binding	molecular_function	"Interacting selectively and non-covalently with lipoteichoic acid." [GOC:add, PMID:14665680]
EOG81K1TV	GO:0061057	1/343	peptidoglycan recognition protein signaling pathway	biological_process	"A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280]
EOG81K1TV	GO:0042834	1/343	peptidoglycan binding	molecular_function	"Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226]
EOG8NS5S1	GO:0006012	38/146	galactose metabolic process	biological_process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]
EOG8NS5S1	GO:0003978	38/146	UDP-glucose 4-epimerase activity	molecular_function	"Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2]
EOG8NS5S1	GO:0050662	38/146	coenzyme binding	molecular_function	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
EOG8NS5S1	GO:0044237	38/146	cellular metabolic process	biological_process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
EOG8NS5S1	GO:0003974	1/146	UDP-N-acetylglucosamine 4-epimerase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7]
EOG880MB7	GO:0003676	14/75	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG880MB7	GO:0003964	1/75	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG880MB7	GO:0003723	1/75	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG81K1TZ	GO:0016740	9/88	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG81K1TZ	GO:0006633	9/88	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG81K1TZ	GO:0016021	9/88	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84QWH1	GO:0007476	1/83	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8WHC1B	GO:0008270	2/68	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WHC1B	GO:0032440	1/68	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8WHC1D	GO:0070403	19/59	NAD+ binding	molecular_function	"Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
EOG8WHC1D	GO:0005654	1/59	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG8WHC1D	GO:0006355	1/59	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8WHC1D	GO:0042981	1/59	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8WHC1D	GO:0017136	1/59	NAD-dependent histone deacetylase activity	molecular_function	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone." [EC:3.5.1.17, RHEA:24551]
EOG8WHC1D	GO:0004407	1/59	histone deacetylase activity	molecular_function	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.98, PMID:9893272]
EOG8WHC1D	GO:0008340	1/59	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8WHC1D	GO:0008134	1/59	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8WHC1D	GO:0005634	1/59	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WHC1D	GO:0016575	1/59	histone deacetylation	biological_process	"The modification of histones by removal of acetyl groups." [GOC:ai]
EOG8WHC1D	GO:0006342	1/59	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG8WHC1D	GO:2000253	1/59	positive regulation of feeding behavior	biological_process	"Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol]
EOG8WHC1D	GO:0046872	1/59	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WHC1D	GO:0048149	1/59	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8WHC1D	GO:0005737	1/59	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WHC1D	GO:0035065	1/59	regulation of histone acetylation	biological_process	"Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]
EOG8WHC1D	GO:0006351	1/59	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8VT8F4	GO:0001895	1/60	retina homeostasis	biological_process	"A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178]
EOG8VT8F4	GO:0007603	1/60	phototransduction, visible light	biological_process	"The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
EOG8VT8F4	GO:0072321	1/60	chaperone-mediated protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, mediated by chaperone molecules that bind to the transported proteins." [GOC:mah, PMID:20378773]
EOG8VT8F4	GO:0090314	1/60	positive regulation of protein targeting to membrane	biological_process	"Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]
EOG8VT8F4	GO:0016063	1/60	rhodopsin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
EOG8VT8F4	GO:0071482	1/60	cellular response to light stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]
EOG8VT8F4	GO:0097038	1/60	perinuclear endoplasmic reticulum	cellular_component	"The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]
EOG80CKWZ	GO:0031418	25/105	L-ascorbic acid binding	molecular_function	"Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]
EOG80CKWZ	GO:0005506	25/105	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG80CKWZ	GO:0016706	23/105	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG80CKWZ	GO:0008475	2/105	procollagen-lysine 5-dioxygenase activity	molecular_function	"Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4]
EOG80CKWZ	GO:0005581	2/105	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG80CKWZ	GO:0005615	1/105	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG80CKWZ	GO:0007295	1/105	growth of a germarium-derived egg chamber	biological_process	"Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG80CKWZ	GO:0005783	1/105	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG80CKWZ	GO:0048471	1/105	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG841SV9	GO:0046933	30/88	proton-transporting ATP synthase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]
EOG841SV9	GO:0046961	30/88	proton-transporting ATPase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]
EOG841SV9	GO:0000275	30/88	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	cellular_component	"The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056]
EOG841SV9	GO:0015986	30/88	ATP synthesis coupled proton transport	biological_process	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]
EOG841SV9	GO:0008553	2/88	hydrogen-exporting ATPase activity, phosphorylative mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle." [EC:3.6.3.6]
EOG841SV9	GO:0005515	1/88	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG841SV9	GO:0006979	1/88	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG841SV9	GO:0008340	1/88	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG841SV9	GO:0046331	1/88	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8XPSX2	GO:0003676	1/17	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XPSX2	GO:0008270	1/17	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8C2KR3	GO:0016021	1/80	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C2KR5	GO:0005524	33/100	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8C2KR5	GO:0004674	30/100	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8C2KR5	GO:0016301	3/100	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8C2KR5	GO:0060252	1/100	positive regulation of glial cell proliferation	biological_process	"Any process that activates or increases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb]
EOG8C2KR5	GO:0022008	1/100	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG844P1Q	GO:0005509	23/81	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG844P1Q	GO:0048812	1/81	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8FXTQZ	GO:0006412	28/97	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8FXTQZ	GO:0003735	28/97	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8FXTQZ	GO:0005840	28/97	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8FXTQZ	GO:0000022	1/97	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8FXTQZ	GO:0007052	1/97	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8MGVPP	GO:0005576	1/172	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8MGVPP	GO:0006355	1/172	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8MGVPP	GO:0043565	1/172	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8MGVPJ	GO:0003676	23/88	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MGVPJ	GO:0004527	20/88	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8MGVPJ	GO:0008859	1/88	exoribonuclease II activity	molecular_function	"Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684]
EOG8TTJZM	GO:0046872	2/28	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8JQ6CW	GO:0015031	72/218	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8JQ6CW	GO:0005525	72/218	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8JQ6CW	GO:0007264	72/218	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8JQ6CW	GO:0004767	4/218	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8JQ6CW	GO:0043025	2/218	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8JQ6CW	GO:0005515	1/218	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8JQ6CW	GO:0006897	1/218	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8JQ6CW	GO:0045202	1/218	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8909RT	GO:0016021	10/69	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8909RT	GO:0004930	10/69	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG89628N	GO:0016055	2/10	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG89628N	GO:0007275	2/10	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8JQ6CX	GO:0003677	5/35	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8909RR	GO:0007076	49/148	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8909RR	GO:0000796	49/148	condensin complex	cellular_component	"A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
EOG8909RR	GO:0072587	1/148	DNA topoisomerase (ATP-hydrolyzing) activator activity	molecular_function	"Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah]
EOG8909RR	GO:0000793	1/148	condensed chromosome	cellular_component	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]
EOG8909RR	GO:0007052	1/148	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8909RR	GO:0002009	1/148	morphogenesis of an epithelium	biological_process	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
EOG8909RR	GO:0022008	1/148	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8909RR	GO:0000775	1/148	chromosome, centromeric region	cellular_component	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
EOG8909RR	GO:0051306	1/148	mitotic sister chromatid separation	biological_process	"The process in which sister chromatids are physically detached from each other during mitosis." [GOC:ai]
EOG8909RR	GO:0007443	1/148	Malpighian tubule morphogenesis	biological_process	"The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089]
EOG8909RR	GO:0007424	1/148	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8909RR	GO:0048567	1/148	ectodermal digestive tract morphogenesis	biological_process	"The process in which the anatomical structures of the ectodermal digestive tract are generated and organized. The ectodermal digestive tract includes those portions of the digestive tract that are derived from ectoderm." [GOC:jid]
EOG8909RR	GO:0000070	1/148	mitotic sister chromatid segregation	biological_process	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
EOG8909RR	GO:0008258	1/148	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8909RR	GO:0006099	1/148	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8909RR	GO:0000785	1/148	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG8909RR	GO:0007422	1/148	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8909RR	GO:2000373	1/148	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	biological_process	"Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah]
EOG8X6FP4	GO:0005524	23/101	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X6FP4	GO:0007018	23/101	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8X6FP4	GO:0003777	23/101	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8X6FP4	GO:0005871	22/101	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8X6FP4	GO:0005874	21/101	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8X6FP4	GO:0000278	1/101	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8X6FP4	GO:0007067	1/101	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8X6FP4	GO:0007140	1/101	male meiosis	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
EOG8X6FP4	GO:0051233	1/101	spindle midzone	cellular_component	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
EOG8X6FP4	GO:0005875	1/101	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8X6FP4	GO:0000922	1/101	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8X6FP4	GO:0000212	1/101	meiotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah]
EOG8X6FP4	GO:0040016	1/101	embryonic cleavage	biological_process	"The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300]
EOG8X6FP4	GO:0005737	1/101	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8X6FP4	GO:0016321	1/101	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8X6FP4	GO:0007052	1/101	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8X6FP4	GO:0005876	1/101	spindle microtubule	cellular_component	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]
EOG8X6FP4	GO:0008152	1/101	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8X6FP4	GO:0051257	1/101	meiotic spindle midzone assembly	biological_process	"The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis." [GOC:ai, GOC:expert_rg, GOC:tb]
EOG8909RH	GO:0004721	12/112	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8909RH	GO:0006470	12/112	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8909RH	GO:0005741	12/112	mitochondrial outer membrane	cellular_component	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
EOG8909RH	GO:0016021	9/112	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8909RH	GO:0090141	2/112	positive regulation of mitochondrial fission	biological_process	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8909RH	GO:0005739	1/112	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8909RH	GO:0010821	1/112	regulation of mitochondrion organization	biological_process	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]
EOG8909RH	GO:0071902	1/112	positive regulation of protein serine/threonine kinase activity	biological_process	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]
EOG8909RH	GO:0035970	1/112	peptidyl-threonine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine." [GOC:bf]
EOG8909RH	GO:0004619	1/112	phosphoglycerate mutase activity	molecular_function	"Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1]
EOG8909RH	GO:0043539	1/112	protein serine/threonine kinase activator activity	molecular_function	"Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators]
EOG8909RH	GO:0072347	1/112	response to anesthetic	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart]
EOG8909RH	GO:0005515	1/112	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8909RH	GO:0019900	1/112	kinase binding	molecular_function	"Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]
EOG8909RH	GO:0009408	1/112	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8CRPDG	GO:0004809	26/89	tRNA (guanine-N2-)-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32]
EOG8CRPDG	GO:0003723	25/89	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CRPDG	GO:0046872	1/89	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CRPDG	GO:0000049	1/89	tRNA binding	molecular_function	"Interacting selectively and non-covalently with transfer RNA." [GOC:ai]
EOG8CRPDC	GO:0006486	31/95	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8CRPDC	GO:0016021	31/95	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CRPDC	GO:0005794	30/95	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8CRPDC	GO:0008378	22/95	galactosyltransferase activity	molecular_function	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]
EOG8CRPDC	GO:0047915	9/95	ganglioside galactosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine." [EC:2.4.1.62, MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN]
EOG8CRPDC	GO:0001744	1/95	optic lobe placode formation	biological_process	"Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833]
EOG8CRPDC	GO:0030707	1/95	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8CRPDC	GO:0042248	1/95	maintenance of polarity of follicular epithelium	biological_process	"The maintenance of an established polarized follicular epithelial sheet." [GOC:bf]
EOG8CRPDC	GO:0005576	1/95	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8CRPDC	GO:0046981	1/95	beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids." [GOC:bf, PMID:12130631, PMID:12130651]
EOG8CRPDC	GO:0007219	1/95	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8CRPDC	GO:0016333	1/95	morphogenesis of follicular epithelium	biological_process	"The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl]
EOG8CRPDC	GO:0005795	1/95	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG8CRPDC	GO:0007298	1/95	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8CRPDC	GO:0008375	1/95	acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]
EOG8CRPDC	GO:0000139	1/95	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8CRPDC	GO:0048477	1/95	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8CRPDC	GO:0007293	1/95	germarium-derived egg chamber formation	biological_process	"Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8CRPDC	GO:0007299	1/95	ovarian follicle cell-cell adhesion	biological_process	"The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12642496]
EOG8CRPDC	GO:0006688	1/95	glycosphingolipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators]
EOG8CRPDJ	GO:0003676	26/107	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CRPDJ	GO:0000166	26/107	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8CRPDJ	GO:0005848	1/107	mRNA cleavage stimulating factor complex	cellular_component	"A protein complex required for mRNA cleavage but not for poly(A) addition." [GOC:mah, PMID:10357856]
EOG8CRPDJ	GO:0022008	1/107	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8CRPDJ	GO:0016491	1/107	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8CRPDJ	GO:0003729	1/107	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8CRPDJ	GO:0006379	1/107	mRNA cleavage	biological_process	"Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah]
EOG8CRPDJ	GO:0016301	1/107	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8CRPDJ	GO:0010181	1/107	FMN binding	molecular_function	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]
EOG8CRPDW	GO:0003867	29/99	4-aminobutyrate transaminase activity	molecular_function	"Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [EC:2.6.1.19, GOC:mah]
EOG8CRPDW	GO:0009448	29/99	gamma-aminobutyric acid metabolic process	biological_process	"The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732]
EOG8CRPDW	GO:0030170	29/99	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8NZX8J	GO:0016491	3/183	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8NZX8J	GO:0005737	2/183	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8NZX8J	GO:0018149	2/183	peptide cross-linking	biological_process	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]
EOG8GJ24K	GO:0016021	4/39	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GJ24K	GO:0005267	4/39	potassium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG82Z76D	GO:0005743	51/132	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG82Z76D	GO:0006850	51/132	mitochondrial pyruvate transport	biological_process	"The directed movement of pyruvate, 2-oxopropanoate, into, out of or within a mitochondrion." [GOC:ai]
EOG8FXTQ5	GO:0005525	42/125	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8FXTQ5	GO:0007264	42/125	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8FXTQ5	GO:0015031	37/125	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8FXTQ5	GO:0045202	2/125	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8FXTQ5	GO:0055037	2/125	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG8FXTQ5	GO:0004767	2/125	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8FXTQ5	GO:0006184	1/125	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8FXTQ5	GO:0005769	1/125	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG8FXTQ5	GO:0007422	1/125	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8FXTQ5	GO:0036313	1/125	phosphatidylinositol 3-kinase catalytic subunit binding	molecular_function	"Interacting selectively and non-covalently with the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [GOC:bf, PMID:17475214]
EOG8FXTQ5	GO:0003924	1/125	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8FXTQ5	GO:0005515	1/125	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FXTQ5	GO:0030866	1/125	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8FXTQ9	GO:0003677	343/539	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FXTQ9	GO:0000786	343/539	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8FXTQ9	GO:0005634	343/539	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FXTQ9	GO:0006334	343/539	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8FXTQ9	GO:0005811	111/539	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8FXTQ9	GO:0005515	23/539	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8MGVP1	GO:0008440	27/89	inositol-1,4,5-trisphosphate 3-kinase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11023]
EOG8MGVP1	GO:0052723	2/89	inositol hexakisphosphate 1-kinase activity	molecular_function	"Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179]
EOG8MGVP1	GO:0000832	2/89	inositol hexakisphosphate 5-kinase activity	molecular_function	"Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate." [MetaCyc:2.7.1.152-RXN]
EOG8MGVP1	GO:0052724	2/89	inositol hexakisphosphate 3-kinase activity	molecular_function	"Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179]
EOG8FJBS3	GO:0003676	72/1100	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FJBS3	GO:0003964	71/1100	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8FJBS3	GO:0004523	69/1100	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8FJBS3	GO:0003723	34/1100	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8FJBS3	GO:0008270	8/1100	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FJBS3	GO:0004519	1/1100	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8FJBS3	GO:0004842	1/1100	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8WQ3JX	GO:0016539	1/38	intein-mediated protein splicing	biological_process	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]
EOG8BZQKM	GO:0003964	7/71	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8BZQKM	GO:0004519	6/71	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8BZQKM	GO:0003723	2/71	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8ZGRVG	GO:0016021	4/28	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87WR5K	GO:0004672	3/17	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG87WR5K	GO:0005524	3/17	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8C8B7H	GO:0008270	55/132	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8C8B7H	GO:0016874	2/132	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8Z0DN2	GO:0008191	21/77	metalloendopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]
EOG8Z0DN2	GO:0005576	21/77	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Z0DN2	GO:0035202	1/77	tracheal pit formation in open tracheal system	biological_process	"Formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940, PMID:11992723, PMID:14570584]
EOG8Z0DN2	GO:0042331	1/77	phototaxis	biological_process	"The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981]
EOG8Z0DN2	GO:0007155	1/77	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8Z0DN2	GO:0010951	1/77	negative regulation of endopeptidase activity	biological_process	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG8Z0DN2	GO:0007426	1/77	tracheal outgrowth, open tracheal system	biological_process	"The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8Z0DN2	GO:0048526	1/77	imaginal disc-derived wing expansion	biological_process	"The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing." [GOC:mtg_sensu, GOC:rc]
EOG8Z0DN2	GO:0030425	1/77	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8Z0DN2	GO:0007472	1/77	wing disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8Z0DN2	GO:0046872	1/77	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z0DN2	GO:0071711	1/77	basement membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah]
EOG8Z0DN2	GO:0060232	1/77	delamination	biological_process	"The process of negative regulation of cell adhesion that results in a cell or sheet of cells splitting off from an existing epithelial sheet." [GOC:dph, PMID:16962574, PMID:18343170]
EOG84J50F	GO:0005838	38/102	proteasome regulatory particle	cellular_component	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]
EOG84J50F	GO:0006508	37/102	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG84J50F	GO:0006511	2/102	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG84J50F	GO:0022008	1/102	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84J50F	GO:0008541	1/102	proteasome regulatory particle, lid subcomplex	cellular_component	"The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb]
EOG84J50F	GO:0000502	1/102	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG84J50F	GO:0009987	1/102	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG84J50F	GO:0043161	1/102	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG84J50F	GO:0000022	1/102	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG84J50F	GO:0007052	1/102	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG84J50F	GO:0008283	1/102	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG82586Q	GO:0017150	26/88	tRNA dihydrouridine synthase activity	molecular_function	"Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710]
EOG82586Q	GO:0050660	26/88	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG82586Q	GO:0046872	24/88	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82586Q	GO:0000922	1/88	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG82586Q	GO:0000226	1/88	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG82586Q	GO:0005815	1/88	microtubule organizing center	cellular_component	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416]
EOG85B3WX	GO:0003677	5/70	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG85B3WX	GO:0003682	5/70	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG84J501	GO:0010468	1/82	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG84J501	GO:0000176	1/82	nuclear exosome (RNase complex)	cellular_component	"Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]
EOG84J501	GO:0005737	1/82	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82RGNK	GO:0006355	5/212	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82RGNK	GO:0006200	3/212	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG82RGNK	GO:0007018	3/212	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG82RGNK	GO:0042623	3/212	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG82RGNK	GO:0030286	2/212	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG82RGNK	GO:0005875	2/212	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG82RGNK	GO:0007605	1/212	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8Z0DNP	GO:0016020	2/25	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Z0DNP	GO:0006886	2/25	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8Z0DNP	GO:0016192	2/25	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG82RGNS	GO:0004729	24/89	oxygen-dependent protoporphyrinogen oxidase activity	molecular_function	"Catalysis of the reaction: 3 O(2) + protoporphyrinogen IX = 3 H(2)O(2) + protoporphyrin IX." [EC:1.3.3.4, RHEA:25579]
EOG82RGNS	GO:0006779	24/89	porphyrin-containing compound biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732]
EOG82RGNQ	GO:0004096	47/133	catalase activity	molecular_function	"Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6]
EOG82RGNQ	GO:0020037	47/133	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG82RGNQ	GO:0046872	40/133	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82RGNQ	GO:0006979	26/133	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG82RGNQ	GO:0042744	21/133	hydrogen peroxide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]
EOG82RGNQ	GO:0007568	1/133	aging	biological_process	"A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death (GO:0016265) and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators]
EOG82RGNQ	GO:0042542	1/133	response to hydrogen peroxide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]
EOG82RGNQ	GO:0016209	1/133	antioxidant activity	molecular_function	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
EOG82RGNQ	GO:0005777	1/133	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG82RGNQ	GO:0035206	1/133	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG82RGNQ	GO:0008340	1/133	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8WM785	GO:0005856	5/44	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG82VC04	GO:0005634	3/9	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82VC04	GO:0008270	3/9	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG82VC04	GO:0003676	1/9	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82RGNT	GO:0016740	1/73	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG82RGNT	GO:0004597	1/73	peptide-aspartate beta-dioxygenase activity	molecular_function	"Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2." [EC:1.14.11.16]
EOG88PQ3D	GO:0008234	1/6	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8N5ZC2	GO:0044237	20/89	cellular metabolic process	biological_process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
EOG8N5ZC2	GO:0003824	20/89	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8N5ZC2	GO:0050662	20/89	coenzyme binding	molecular_function	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
EOG8ZGRV0	GO:0003713	3/104	transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8ZGRV0	GO:0046975	3/104	histone methyltransferase activity (H3-K36 specific)	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein." [GOC:ai]
EOG8ZGRV0	GO:0046331	1/104	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8ZGRV0	GO:0030785	1/104	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine." [EC:2.1.1.127]
EOG815JVW	GO:0016788	11/57	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG815JVW	GO:0003676	1/57	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JHFZH	GO:0015992	32/111	proton transport	biological_process	"The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
EOG8JHFZH	GO:0016820	32/111	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	molecular_function	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]
EOG8JHFZH	GO:0016471	31/111	vacuolar proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG8JHFZH	GO:0001700	1/111	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8JHFZH	GO:0015991	1/111	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8JHFZH	GO:0033181	1/111	plasma membrane proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
EOG8JHFZH	GO:0000221	1/111	vacuolar proton-transporting V-type ATPase, V1 domain	cellular_component	"The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG8H74TZ	GO:0016772	1/10	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG86HJTF	GO:0006952	1/21	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG86HJTC	GO:0008270	6/40	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG86HJTC	GO:0003676	6/40	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8T7BHV	GO:0045454	28/86	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8T7BHV	GO:0015035	26/86	protein disulfide oxidoreductase activity	molecular_function	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]
EOG8T7BHV	GO:0006662	26/86	glycerol ether metabolic process	biological_process	"The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732]
EOG8T7BHV	GO:0005783	25/86	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8T7BHV	GO:0003756	25/86	protein disulfide isomerase activity	molecular_function	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1]
EOG8T7BHV	GO:0019511	1/86	peptidyl-proline hydroxylation	biological_process	"The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline." [GOC:mah]
EOG8T7BHV	GO:0034976	1/86	response to endoplasmic reticulum stress	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]
EOG8T7BHV	GO:0060187	1/86	cell pole	cellular_component	"Either of two different areas at opposite ends of an axis of a cell." [GOC:dph]
EOG8T7BHV	GO:0070732	1/86	spindle envelope	cellular_component	"An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase." [GOC:mah, GOC:sart, PMID:19417004, PMID:6428889]
EOG8T7BHV	GO:0005635	1/86	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG8T7BHV	GO:1902175	1/86	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]
EOG8T7BHV	GO:0045169	1/86	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG8T7BHV	GO:0043025	1/86	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8T7BHV	GO:0048471	1/86	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8T7BHV	GO:0005737	1/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8T7BHV	GO:0005811	1/86	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8T7BHV	GO:0005788	1/86	endoplasmic reticulum lumen	cellular_component	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]
EOG8T7BHV	GO:0006457	1/86	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8T7BHV	GO:0016853	1/86	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8T7BHV	GO:0016757	1/86	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8T7BHV	GO:0005615	1/86	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8T7BHV	GO:0005791	1/86	rough endoplasmic reticulum	cellular_component	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]
EOG8T7BHV	GO:0004579	1/86	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	molecular_function	"Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119]
EOG8THZ80	GO:0016787	3/145	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8THZ80	GO:0016791	3/145	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG8THZ80	GO:0016311	2/145	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG8T7BHH	GO:0016740	1/90	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8T7BHH	GO:0005737	1/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8T7BHN	GO:0004767	45/153	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8T7BHN	GO:0006685	45/153	sphingomyelin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732]
EOG8T7BHN	GO:0016787	2/153	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8BCH22	GO:0016758	383/1077	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8BCH22	GO:0030259	14/1077	lipid glycosylation	biological_process	"Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah]
EOG8BCH22	GO:0015020	13/1077	glucuronosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17]
EOG8BCH22	GO:0030246	12/1077	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8BCH22	GO:0016999	11/1077	antibiotic metabolic process	biological_process	"The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2]
EOG8BCH22	GO:0016740	3/1077	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8BCH22	GO:0004181	1/1077	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG8BCH22	GO:0008168	1/1077	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8BCH22	GO:0003851	1/1077	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45]
EOG8BCH22	GO:0008270	1/1077	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BCH22	GO:0003676	1/1077	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BCH22	GO:0002121	1/1077	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG88D384	GO:0016021	10/53	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88D384	GO:0007156	10/53	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG88D384	GO:0005509	10/53	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG88D384	GO:0005886	10/53	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG88D384	GO:0004022	1/53	alcohol dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
EOG89S8N3	GO:0070389	2/85	chaperone cofactor-dependent protein refolding	biological_process	"The process of assisting in the restoration of the biological activity of an unfolded or misfolded protein, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:mah, GOC:rb]
EOG89S8N3	GO:0005737	2/85	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG89S8N3	GO:0030544	2/85	Hsp70 protein binding	molecular_function	"Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size." [ISBN:0198506732]
EOG89S8N3	GO:0043234	2/85	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG89S8N3	GO:0006950	1/85	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8V19DR	GO:0004222	23/91	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8V19DR	GO:0008270	21/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V19DR	GO:0008237	1/91	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8V19DR	GO:0006509	1/91	membrane protein ectodomain proteolysis	biological_process	"The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/]
EOG8V19DR	GO:0016021	1/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D81MW	GO:0008080	22/171	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG88SK8F	GO:0046872	1/73	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8SFCNZ	GO:0007297	1/73	ovarian follicle cell migration	biological_process	"The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8SFCNZ	GO:0016324	1/73	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8SFCNZ	GO:0005886	1/73	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8SFCNZ	GO:0007605	1/73	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8SFCNZ	GO:0035324	1/73	female germline ring canal	cellular_component	"An intercellular bridge that connects the germline cells of a female cyst." [PMID:9635420]
EOG8SFCNZ	GO:0007293	1/73	germarium-derived egg chamber formation	biological_process	"Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG89S8NR	GO:0008076	1/27	voltage-gated potassium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
EOG89S8NR	GO:0005249	1/27	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG88SK87	GO:0007052	1/92	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG88SK87	GO:0070822	1/92	Sin3-type complex	cellular_component	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]
EOG8F7R11	GO:0016021	3/229	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F7R11	GO:0006909	3/229	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8F7R11	GO:0042742	2/229	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8F7R11	GO:0005886	1/229	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8F7R11	GO:0006910	1/229	phagocytosis, recognition	biological_process	"The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149]
EOG8F7R11	GO:0046331	1/229	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8F7R11	GO:0009986	1/229	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8F7R11	GO:0005615	1/229	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8F7R11	GO:0006898	1/229	receptor-mediated endocytosis	biological_process	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
EOG8F7R11	GO:0005044	1/229	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8F7R11	GO:0008233	1/229	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8F7R11	GO:0042834	1/229	peptidoglycan binding	molecular_function	"Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226]
EOG8F7R16	GO:0022904	3/48	respiratory electron transport chain	biological_process	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]
EOG8F7R16	GO:0009055	3/48	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8F7R16	GO:0016491	3/48	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8F7R16	GO:0016020	2/48	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8F7R16	GO:0016021	1/48	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F7R16	GO:0007283	1/48	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8F7R16	GO:0005743	1/48	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8F7R16	GO:0070469	1/48	respiratory chain	cellular_component	"The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684]
EOG8F7R16	GO:0046872	1/48	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8BCH2D	GO:0005524	24/99	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8BCH2D	GO:0016874	21/99	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8BCH2D	GO:0046872	18/99	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8BCH2D	GO:0004775	3/99	succinate-CoA ligase (ADP-forming) activity	molecular_function	"Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [EC:6.2.1.5]
EOG8BCH2D	GO:0007052	1/99	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8BCH2D	GO:0005875	1/99	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8BCH2D	GO:0005813	1/99	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8BCH2D	GO:0010824	1/99	regulation of centrosome duplication	biological_process	"Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]
EOG8THZ8Q	GO:0005509	37/100	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8THZ8Q	GO:0005955	2/100	calcineurin complex	cellular_component	"A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [ISBN:019859951]
EOG8THZ8Q	GO:0008597	2/100	calcium-dependent protein serine/threonine phosphatase regulator activity	molecular_function	"Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase." [EC:3.1.3.16, GOC:ai]
EOG8THZ8Q	GO:0005516	2/100	calmodulin binding	molecular_function	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
EOG8THZ8Q	GO:0030431	2/100	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8THZ8Q	GO:0016192	2/100	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8THZ8Q	GO:0050790	2/100	regulation of catalytic activity	biological_process	"Any process that modulates the activity of an enzyme." [GOC:ai]
EOG8THZ8Q	GO:0007269	2/100	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8THZ8Q	GO:0006470	2/100	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8THZ8Q	GO:0008021	2/100	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8THZ8Q	GO:0045214	1/100	sarcomere organization	biological_process	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
EOG8THZ8Q	GO:0005515	1/100	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8THZ8Q	GO:0051533	1/100	positive regulation of NFAT protein import into nucleus	biological_process	"Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai]
EOG8THZ8Q	GO:0007126	1/100	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8THZ8Q	GO:0030241	1/100	skeletal muscle myosin thick filament assembly	biological_process	"The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle]
EOG8THZ8Q	GO:0032440	1/100	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG86HJT4	GO:0007399	1/75	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG86HJT5	GO:0003700	35/127	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG86HJT5	GO:0005634	35/127	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86HJT5	GO:0043565	26/127	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG86HJT5	GO:0000060	3/127	protein import into nucleus, translocation	biological_process	"A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope." [GOC:curators, ISBN:0198506732, PMID:14570049, PMID:9126736]
EOG86HJT5	GO:0001654	3/127	eye development	biological_process	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
EOG86HJT5	GO:0003677	3/127	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86HJT5	GO:0007422	3/127	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG86HJT5	GO:0006357	3/127	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG86HJT5	GO:0005667	3/127	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG86HJT5	GO:0006351	2/127	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG86HJT5	GO:0007432	1/127	salivary gland boundary specification	biological_process	"Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957]
EOG86HJT5	GO:0045944	1/127	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG86HJT5	GO:0007479	1/127	leg disc proximal/distal pattern formation	biological_process	"The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf]
EOG86HJT5	GO:0004801	1/127	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	molecular_function	"Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [EC:2.2.1.2]
EOG86HJT5	GO:0003713	1/127	transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG86HJT5	GO:0005737	1/127	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86HJT5	GO:0007525	1/127	somatic muscle development	biological_process	"The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
EOG86HJT5	GO:0007438	1/127	oenocyte development	biological_process	"The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397]
EOG86HJT5	GO:0046982	1/127	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG86HJT5	GO:0003705	1/127	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG86HJT5	GO:0006366	1/127	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG86HJT5	GO:0042659	1/127	regulation of cell fate specification	biological_process	"Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators]
EOG86HJT5	GO:0033613	1/127	activating transcription factor binding	molecular_function	"Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription." [GOC:mah, GOC:txnOH]
EOG86HJT5	GO:0008134	1/127	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG86HJT5	GO:0005515	1/127	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG86HJT5	GO:0007420	1/127	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG8ZPH81	GO:0009072	28/106	aromatic amino acid family metabolic process	biological_process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]
EOG8ZPH81	GO:0004334	28/106	fumarylacetoacetase activity	molecular_function	"Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+)." [EC:3.7.1.2, RHEA:10247]
EOG8ZPH81	GO:0003723	5/106	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8ZPH81	GO:0008173	5/106	RNA methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]
EOG8ZPH81	GO:0006396	5/106	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8V71Z5	GO:0003677	25/92	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8V71Z5	GO:0003899	25/92	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8V71Z5	GO:0005634	24/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8V71Z5	GO:0006351	24/92	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8V71Z5	GO:0006360	1/92	transcription from RNA polymerase I promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
EOG8V71Z5	GO:0005736	1/92	DNA-directed RNA polymerase I complex	cellular_component	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8BCH2V	GO:0005875	2/138	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8BCH2V	GO:0030951	1/138	establishment or maintenance of microtubule cytoskeleton polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah]
EOG8BCH2V	GO:0008017	1/138	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8BCH2V	GO:0051225	1/138	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG8BCH2V	GO:0040001	1/138	establishment of mitotic spindle localization	biological_process	"The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai]
EOG8BCH2V	GO:0005515	1/138	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8BCH2V	GO:0007059	1/138	chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
EOG8BCH2V	GO:0007626	1/138	locomotory behavior	biological_process	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
EOG8BCH2V	GO:0000226	1/138	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8BCH2V	GO:0007605	1/138	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8BCH2V	GO:0005874	1/138	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8BCH2V	GO:0017022	1/138	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8BCH2V	GO:0007629	1/138	flight behavior	biological_process	"The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
EOG8BCH2V	GO:0035011	1/138	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG8BCH2V	GO:0007017	1/138	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8BCH2V	GO:0005737	1/138	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8BCH2V	GO:0000022	1/138	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8BCH2V	GO:0007423	1/138	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8BCH2V	GO:0042060	1/138	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8BCH2V	GO:0007052	1/138	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8BCH2V	GO:0030589	1/138	pseudocleavage involved in syncytial blastoderm formation	biological_process	"Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8R7XT1	GO:0035556	18/60	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8RFP7Z	GO:0008270	6/57	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RFP7Z	GO:0016491	5/57	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8RFP7Z	GO:0003960	1/57	NADPH:quinone reductase activity	molecular_function	"Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5]
EOG8WHC0K	GO:0005814	1/87	centriole	cellular_component	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
EOG8WHC0K	GO:0035044	1/87	sperm aster formation	biological_process	"Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei." [GOC:bf, ISBN:0879694238]
EOG8WHC0K	GO:0030953	1/87	astral microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles." [GOC:mah]
EOG8WHC0K	GO:0005813	1/87	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8WHC0K	GO:0000242	1/87	pericentriolar material	cellular_component	"A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]
EOG8WHC0K	GO:0051297	1/87	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8WHC0K	GO:0007052	1/87	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8V45PK	GO:0003676	1/38	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8R2696	GO:0006334	23/75	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8R2696	GO:0005634	23/75	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80P6Q1	GO:0016021	2/83	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JWXTK	GO:0006310	11/62	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8JWXTK	GO:0003676	11/62	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JWXTK	GO:0008026	11/62	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8JWXTK	GO:0005524	11/62	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8R52HG	GO:0004014	28/92	adenosylmethionine decarboxylase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2)." [EC:4.1.1.50, RHEA:15984]
EOG8R52HG	GO:0006597	28/92	spermine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [CHEBI:15746, GOC:curators]
EOG8R52HG	GO:0008295	28/92	spermidine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732]
EOG8R52HG	GO:0006557	19/92	S-adenosylmethioninamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE]
EOG8R52HG	GO:0050829	1/92	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG81G5K0	GO:0003676	3/19	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V19G8	GO:0048060	1/82	negative gravitaxis	biological_process	"The directed movement of a motile cell or organism away from the source of gravity." [GOC:jid]
EOG8V19G8	GO:0070286	1/82	axonemal dynein complex assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:mah, PMID:19052621]
EOG8V19G8	GO:0035253	1/82	ciliary rootlet	cellular_component	"A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [GOC:cilia, PMID:12427867]
EOG8V19G8	GO:0031514	1/82	motile cilium	cellular_component	"A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998]
EOG8V19G8	GO:0003341	1/82	cilium movement	biological_process	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]
EOG8V19G8	GO:0044297	1/82	cell body	cellular_component	"The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]
EOG8V19G8	GO:0097542	1/82	ciliary tip	cellular_component	"Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction." [GOC:cilia, PMID:23970417]
EOG8JWXTR	GO:0016021	26/87	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JWXTR	GO:0003333	1/87	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG8JWXTR	GO:0007632	1/87	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG8JWXTR	GO:0015171	1/87	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8HHRGX	GO:0005549	9/94	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8HHRGX	GO:0004984	9/94	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8HHRGX	GO:0016021	6/94	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HHRGX	GO:0004930	6/94	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8HHRGX	GO:0016020	3/94	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HHRGX	GO:0005886	2/94	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8BP3SK	GO:0031227	1/88	intrinsic component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
EOG8BP3SK	GO:0006505	1/88	GPI anchor metabolic process	biological_process	"The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732]
EOG8BP3SK	GO:0006506	1/88	GPI anchor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
EOG8BP3SK	GO:0000139	1/88	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8BP3SK	GO:0016788	1/88	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG8BP3SK	GO:0016021	1/88	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HHRGV	GO:0005525	23/89	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8HHRGV	GO:0007275	1/89	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8HHRGV	GO:0040018	1/89	positive regulation of multicellular organism growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8HHRGV	GO:0006184	1/89	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8HHRGV	GO:0046626	1/89	regulation of insulin receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8HHRGV	GO:0005737	1/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HHRGV	GO:0042254	1/89	ribosome biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
EOG8HHRGV	GO:0005783	1/89	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8HHRGV	GO:0051168	1/89	nuclear export	biological_process	"The directed movement of substances out of the nucleus." [GOC:ai]
EOG8HHRGV	GO:0015030	1/89	Cajal body	cellular_component	"A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]
EOG8HHRGV	GO:0003924	1/89	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8HHRGV	GO:0015031	1/89	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8HHRGV	GO:0030307	1/89	positive regulation of cell growth	biological_process	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8PP0XD	GO:0008270	29/100	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PP0XD	GO:0005622	28/100	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8PP0XD	GO:0048666	1/100	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8PP0XD	GO:0005634	1/100	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PP0XD	GO:0007411	1/100	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8PP0XD	GO:0048813	1/100	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8PP0XD	GO:0003682	1/100	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8PP0XD	GO:0006325	1/100	chromatin organization	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
EOG8PP0XD	GO:0007422	1/100	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8PP0XD	GO:0004402	1/100	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8PP0XD	GO:0003676	1/100	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80KBCM	GO:0035556	30/108	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG80KBCM	GO:0004435	25/108	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG80KBCM	GO:0004871	24/108	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG80KBCM	GO:0005509	20/108	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG80KBCM	GO:0006629	18/108	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG80KBCM	GO:0009395	11/108	phospholipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG80KBCM	GO:0008081	4/108	phosphoric diester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]
EOG80KBCM	GO:0030307	1/108	positive regulation of cell growth	biological_process	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG80KBCM	GO:0007298	1/108	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG80KBCM	GO:0032868	1/108	response to insulin	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]
EOG80KBCM	GO:0032065	1/108	cortical protein anchoring	biological_process	"A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw]
EOG80KBCM	GO:0005938	1/108	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG80KBCM	GO:0045596	1/108	negative regulation of cell differentiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]
EOG80KBCM	GO:0042059	1/108	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG80KBCM	GO:0005543	1/108	phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8HHRGB	GO:0007018	1/126	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8HHRGB	GO:0006200	1/126	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8HHRGB	GO:0042623	1/126	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8HHRGB	GO:0030286	1/126	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8R52H1	GO:0005524	5/39	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8R52H1	GO:0003777	5/39	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8R52H1	GO:0005871	5/39	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8R52H1	GO:0007018	5/39	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8R52H1	GO:0005874	4/39	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG873S59	GO:0003824	14/96	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG873S52	GO:0050660	110/344	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG873S52	GO:0009055	107/344	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG873S52	GO:0051537	105/344	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG873S52	GO:0016614	104/344	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG873S52	GO:0005506	90/344	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG873S52	GO:0046872	23/344	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG873S52	GO:0016491	9/344	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG873S52	GO:0008762	6/344	UDP-N-acetylmuramate dehydrogenase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158]
EOG873S52	GO:0051536	2/344	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG873S52	GO:0018492	1/344	carbon-monoxide dehydrogenase (acceptor) activity	molecular_function	"Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.99.2]
EOG873S52	GO:0007155	1/344	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG873S52	GO:0016020	1/344	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG873S56	GO:0005891	3/30	voltage-gated calcium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]
EOG873S56	GO:0005245	3/30	voltage-gated calcium channel activity	molecular_function	"Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
EOG8J6V71	GO:0071011	1/119	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8J6V71	GO:0008380	1/119	RNA splicing	biological_process	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]
EOG8J6V71	GO:0000398	1/119	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8J6V71	GO:0071013	1/119	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG86Q97P	GO:0016021	129/334	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86Q97P	GO:0004672	1/334	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG86Q97P	GO:0005524	1/334	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG86Q97P	GO:0045169	1/334	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG8NZX77	GO:0015074	206/1674	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8NZX77	GO:0003964	173/1674	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8NZX77	GO:0003723	170/1674	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8NZX77	GO:0003676	151/1674	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NZX77	GO:0008270	67/1674	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NZX77	GO:0004190	64/1674	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8NZX77	GO:0004523	2/1674	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8NZX77	GO:0003677	2/1674	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NZX77	GO:0003899	1/1674	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8NZX77	GO:0043565	1/1674	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NZX77	GO:0005634	1/1674	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NZX77	GO:0003700	1/1674	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NZX77	GO:0004519	1/1674	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8NZX77	GO:0046872	1/1674	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NZX77	GO:0019048	1/1674	modulation by virus of host morphology or physiology	biological_process	"The process in which a virus effects a change in the structure or processes of its host organism." [GOC:bf, GOC:jl, ISBN:0781718325, UniProtKB-KW:KW-0945]
EOG8NZX77	GO:0019031	1/1674	viral envelope	cellular_component	"The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope]
EOG8NZX77	GO:0006351	1/1674	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8NZX77	GO:0008233	1/1674	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8GJ25J	GO:0006888	25/68	ER to Golgi vesicle-mediated transport	biological_process	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]
EOG8GJ25J	GO:0005622	25/68	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG86Q97N	GO:0016021	3/36	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86Q97N	GO:0019646	3/36	aerobic electron transport chain	biological_process	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport]
EOG86Q97N	GO:0004129	3/36	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG86Q97N	GO:0005739	2/36	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG86Q97N	GO:0005743	1/36	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8DV838	GO:0051726	1/61	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG87SVVB	GO:0038032	24/89	termination of G-protein coupled receptor signaling pathway	biological_process	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]
EOG87SVVB	GO:0016301	3/89	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8XSP45	GO:0016787	21/89	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8XSP45	GO:0045134	2/89	uridine-diphosphatase activity	molecular_function	"Catalysis of the reaction: UDP + H2O = UMP + phosphate." [EC:3.6.1.6]
EOG8XSP45	GO:0008152	1/89	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8XSP45	GO:0004382	1/89	guanosine-diphosphatase activity	molecular_function	"Catalysis of the reaction: GDP + H2O = GMP + phosphate." [EC:3.6.1.42, PMID:2989286]
EOG8XSP45	GO:0005737	1/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XSP45	GO:0017111	1/89	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG80S2WJ	GO:0016491	161/516	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG80S2WJ	GO:0004032	11/516	alditol:NADP+ 1-oxidoreductase activity	molecular_function	"Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21]
EOG80S2WJ	GO:0035220	1/516	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG80S2WJ	GO:0047006	1/516	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	molecular_function	"Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone." [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN]
EOG80S2WJ	GO:0016319	1/516	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG80S2WJ	GO:0008106	1/516	alcohol dehydrogenase (NADP+) activity	molecular_function	"Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2]
EOG80S2WJ	GO:0022416	1/516	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG87SVV0	GO:0006886	26/96	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG87SVV0	GO:0045335	26/96	phagocytic vesicle	cellular_component	"A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]
EOG87SVV0	GO:0005547	26/96	phosphatidylinositol-3,4,5-trisphosphate binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl]
EOG87SVV0	GO:0090389	26/96	phagosome-lysosome fusion involved in apoptotic cell clearance	biological_process	"The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb]
EOG87SVV0	GO:0007067	16/96	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG87SVV0	GO:0005886	1/96	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG87SVV0	GO:0005789	1/96	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG87SVV0	GO:0016023	1/96	cytoplasmic membrane-bounded vesicle	cellular_component	"A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
EOG87SVV0	GO:0016758	1/96	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG87SVV0	GO:0005768	1/96	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG87SVV0	GO:0071456	1/96	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG87SVV0	GO:0000045	1/96	autophagosome assembly	biological_process	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]
EOG87SVV0	GO:0035091	1/96	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG8C2KQR	GO:0052689	3/95	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG8C2KQR	GO:0007155	1/95	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8C2KQR	GO:0016021	1/95	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C2KQR	GO:0007413	1/95	axonal fasciculation	biological_process	"The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh]
EOG8C2KQR	GO:0007417	1/95	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8C2KQR	GO:0007411	1/95	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8C2KQR	GO:0016323	1/95	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG8C2KQR	GO:0007409	1/95	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8C2KQR	GO:0005886	1/95	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG86Q973	GO:0005737	25/105	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86Q973	GO:0008152	5/105	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG86Q973	GO:0016020	5/105	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG86Q973	GO:0042171	5/105	lysophosphatidic acid acyltransferase activity	molecular_function	"Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [GOC:ab, PMID:16369050]
EOG86Q973	GO:0050803	5/105	regulation of synapse structure or activity	biological_process	"Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]
EOG86Q973	GO:0048488	5/105	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG86Q973	GO:0005829	1/105	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG86Q973	GO:0016746	1/105	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG86Q973	GO:0007269	1/105	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG86Q973	GO:0005543	1/105	phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG86Q973	GO:0097320	1/105	membrane tubulation	biological_process	"A modification in a plasma membrane resulting in formation of a tubular invagination." [GOC:BHF, PMID:15252009, PMID:20730103]
EOG8XWJDF	GO:0003700	2/40	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8XWJDF	GO:0005634	2/40	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XWJDF	GO:0043565	2/40	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG880MCR	GO:0015629	33/101	actin cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
EOG880MCR	GO:0030042	33/101	actin filament depolymerization	biological_process	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]
EOG880MCR	GO:0003779	2/101	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG880MCR	GO:0001745	1/101	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG880MCR	GO:0022008	1/101	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG880MCR	GO:0042067	1/101	establishment of ommatidial planar polarity	biological_process	"The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
EOG880MCR	GO:0005622	1/101	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG880MCR	GO:0007409	1/101	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG880MCR	GO:0005737	1/101	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG880MCR	GO:0000915	1/101	actomyosin contractile ring assembly	biological_process	"The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
EOG880MCR	GO:0042052	1/101	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG880MCR	GO:0007298	1/101	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG880MCR	GO:0030041	1/101	actin filament polymerization	biological_process	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG880MCR	GO:0036011	1/101	imaginal disc-derived leg segmentation	biological_process	"Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf]
EOG880MCR	GO:0008585	1/101	female gonad development	biological_process	"The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb]
EOG880MCR	GO:0000902	1/101	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG880MCR	GO:0001737	1/101	establishment of imaginal disc-derived wing hair orientation	biological_process	"Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]
EOG880MCR	GO:0048749	1/101	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG880MCR	GO:0007015	1/101	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG880MCR	GO:0001736	1/101	establishment of planar polarity	biological_process	"Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
EOG880MCR	GO:0010591	1/101	regulation of lamellipodium assembly	biological_process	"Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG880MCR	GO:0016363	1/101	nuclear matrix	cellular_component	"The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]
EOG880MCR	GO:0016319	1/101	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG880MCR	GO:0000281	1/101	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG880MCR	GO:0005875	1/101	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG88WFHG	GO:0003735	24/65	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG88WFHG	GO:0006412	24/65	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG88WFHG	GO:0005840	23/65	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG88WFHG	GO:0005763	1/65	mitochondrial small ribosomal subunit	cellular_component	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
EOG8NZX7T	GO:0006184	18/60	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8NZX7T	GO:0005525	18/60	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8NZX7T	GO:0016020	18/60	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NZX7T	GO:0007264	18/60	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8NZX7T	GO:0004767	1/60	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG880MCN	GO:0005840	1/44	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8NS5RG	GO:0004503	2/265	monophenol monooxygenase activity	molecular_function	"Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1, GOC:bf, GOC:sart, PMID:4965136]
EOG8NS5RG	GO:0008045	1/265	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8NS5RG	GO:0016201	1/265	synaptic target inhibition	biological_process	"The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]
EOG8NS5RG	GO:0005811	1/265	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8NS5RG	GO:0046872	1/265	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NS5RG	GO:0005616	1/265	larval serum protein complex	cellular_component	"A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, PMID:6781759]
EOG8NS5RG	GO:0045735	1/265	nutrient reservoir activity	molecular_function	"Functions in the storage of nutritious substrates." [GOC:ai]
EOG8NS5RG	GO:0016491	1/265	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8SXQTS	GO:0003824	1/86	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8XWJDW	GO:0003677	15/33	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8WQ3GT	GO:0004831	27/100	tyrosine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.1, RHEA:10223]
EOG8WQ3GT	GO:0005524	27/100	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WQ3GT	GO:0006437	26/100	tyrosyl-tRNA aminoacylation	biological_process	"The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8WQ3GT	GO:0005737	26/100	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WQ3GT	GO:0000049	25/100	tRNA binding	molecular_function	"Interacting selectively and non-covalently with transfer RNA." [GOC:ai]
EOG8WQ3GT	GO:0006418	1/100	tRNA aminoacylation for protein translation	biological_process	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]
EOG8WQ3GQ	GO:0004619	4/17	phosphoglycerate mutase activity	molecular_function	"Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1]
EOG8WQ3GQ	GO:0030145	4/17	manganese ion binding	molecular_function	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
EOG8WQ3GQ	GO:0006007	4/17	glucose catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai]
EOG8WQ3GQ	GO:0005737	4/17	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WQ3GR	GO:0005634	25/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WQ3GR	GO:0006470	25/84	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8WQ3GR	GO:0005737	25/84	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WQ3GR	GO:0004721	24/84	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8WQ3GR	GO:0046872	23/84	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WQ3GR	GO:0004722	1/84	protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
EOG8WQ3GR	GO:0000278	1/84	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8SR0BG	GO:0006144	21/57	purine nucleobase metabolic process	biological_process	"The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [CHEBI:26386, GOC:go_curators]
EOG8SR0BG	GO:0005777	21/57	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8SR0BG	GO:0004846	21/57	urate oxidase activity	molecular_function	"Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide." [EC:1.7.3.3]
EOG8SR0BG	GO:0019628	21/57	urate catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine." [ISBN:0198506732]
EOG8SR0BG	GO:0019428	1/57	allantoin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:go_curators]
EOG8QZB1F	GO:0003899	26/112	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8QZB1F	GO:0006351	25/112	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8QZB1F	GO:0003677	12/112	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8QZB1F	GO:0005875	1/112	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8QZB1F	GO:0006383	1/112	transcription from RNA polymerase III promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH]
EOG8QZB1F	GO:0006360	1/112	transcription from RNA polymerase I promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
EOG8P2SG7	GO:0005267	23/95	potassium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8P2SG7	GO:0016021	23/95	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S7N57	GO:0016559	21/64	peroxisome fission	biological_process	"The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507]
EOG8S7N57	GO:0005779	21/64	integral component of peroxisomal membrane	cellular_component	"The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah]
EOG8S7N57	GO:0007031	1/64	peroxisome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
EOG88PQ0C	GO:0016597	1/60	amino acid binding	molecular_function	"Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]
EOG88PQ0C	GO:0008152	1/60	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8SR0BR	GO:0008476	26/92	protein-tyrosine sulfotransferase activity	molecular_function	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20]
EOG8SR0BR	GO:0006478	26/92	peptidyl-tyrosine sulfation	biological_process	"The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine." [RESID:AA0172]
EOG8SR0BR	GO:0016021	1/92	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SR0BR	GO:0000139	1/92	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8SR0BR	GO:0009306	1/92	protein secretion	biological_process	"The controlled release of proteins from a cell." [GOC:ai]
EOG8SR0BR	GO:0005794	1/92	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG844P06	GO:0016021	81/188	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG844P06	GO:0005524	81/188	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG844P06	GO:0042626	77/188	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG844P06	GO:0008559	6/188	xenobiotic-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44]
EOG844P06	GO:0031427	4/188	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG844P06	GO:0005886	4/188	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG844P06	GO:0055085	4/188	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG844P06	GO:0015440	2/188	peptide-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [EC:3.6.3.43]
EOG844P06	GO:0006855	2/188	drug transmembrane transport	biological_process	"The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:ai, GOC:bf]
EOG844P06	GO:0015238	1/188	drug transmembrane transporter activity	molecular_function	"Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [ISBN:0198506732]
EOG844P06	GO:0060857	1/188	establishment of glial blood-brain barrier	biological_process	"Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
EOG844P06	GO:0008354	1/188	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG844P06	GO:0042908	1/188	xenobiotic transport	biological_process	"The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
EOG844P06	GO:0001666	1/188	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG844P06	GO:0005919	1/188	pleated septate junction	cellular_component	"A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298]
EOG844P06	GO:0015562	1/188	efflux transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG844P06	GO:0043190	1/188	ATP-binding cassette (ABC) transporter complex	cellular_component	"A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107]
EOG844P06	GO:0005887	1/188	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FXTP3	GO:0016021	19/50	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG889719	GO:0005524	280/803	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG889719	GO:0016021	278/803	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG889719	GO:0042626	272/803	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG889719	GO:0008559	6/803	xenobiotic-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44]
EOG889719	GO:0032440	5/803	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG889719	GO:0003676	2/803	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG889719	GO:0016887	2/803	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG889719	GO:0008270	2/803	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG889719	GO:0042060	1/803	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG889719	GO:0000776	1/803	kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG889719	GO:0048190	1/803	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG889719	GO:0006200	1/803	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG889719	GO:0034508	1/803	centromere complex assembly	biological_process	"The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw]
EOG889719	GO:0046688	1/803	response to copper ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai]
EOG889719	GO:0034059	1/803	response to anoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:kmv]
EOG889719	GO:0046331	1/803	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG889719	GO:0007275	1/803	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG889719	GO:0010043	1/803	response to zinc ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm]
EOG889719	GO:0031427	1/803	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG889719	GO:0001666	1/803	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG889719	GO:0043492	1/803	ATPase activity, coupled to movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance." [GOC:jl]
EOG8003ZF	GO:0005737	73/266	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8003ZF	GO:0008565	73/266	protein transporter activity	molecular_function	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
EOG8003ZF	GO:0005634	73/266	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8003ZF	GO:0006606	72/266	protein import into nucleus	biological_process	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]
EOG8003ZF	GO:0017022	1/266	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8003ZF	GO:0007291	1/266	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8003ZF	GO:0051298	1/266	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8003ZF	GO:0042332	1/266	gravitaxis	biological_process	"The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
EOG8003ZF	GO:0005811	1/266	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8003ZF	GO:0007283	1/266	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8003ZF	GO:0051533	1/266	positive regulation of NFAT protein import into nucleus	biological_process	"Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai]
EOG8003ZF	GO:0007095	1/266	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8003ZF	GO:0009411	1/266	response to UV	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]
EOG8003ZF	GO:0006607	1/266	NLS-bearing protein import into nucleus	biological_process	"The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai]
EOG8003ZF	GO:0005875	1/266	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8003ZF	GO:0048542	1/266	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG8003ZF	GO:0007301	1/266	female germline ring canal formation	biological_process	"Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238]
EOG8FJBR5	GO:0008270	1/185	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FJBR5	GO:0003677	1/185	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8P5NQQ	GO:0006470	39/111	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8P5NQQ	GO:0004722	39/111	protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
EOG8P5NQQ	GO:0046872	39/111	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8P5NQQ	GO:0003824	1/111	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8P5NQR	GO:0016021	28/92	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8P5NQR	GO:0016020	1/92	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8P5NQR	GO:0008654	1/92	phospholipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8P5NQR	GO:0071617	1/92	lysophospholipid acyltransferase activity	molecular_function	"Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk]
EOG8P5NQR	GO:0007009	1/92	plasma membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8P5NQR	GO:0047184	1/92	1-acylglycerophosphocholine O-acyltransferase activity	molecular_function	"Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN]
EOG8P5NQR	GO:0030258	1/92	lipid modification	biological_process	"The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]
EOG8P5NQR	GO:0008354	1/92	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8P5NQR	GO:0007291	1/92	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8B8MT2	GO:0000226	28/96	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8B8MT2	GO:0005874	27/96	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8B8MT2	GO:0016787	24/96	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8B8MT2	GO:0060052	1/96	neurofilament cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins." [GOC:dph]
EOG8B8MT2	GO:0048749	1/96	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8B8MT2	GO:0008017	1/96	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8B8MT2	GO:0007399	1/96	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8B8MT2	GO:0015630	1/96	microtubule cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]
EOG8B8MT2	GO:0005515	1/96	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8B8MT2	GO:0048813	1/96	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8B8MT2	GO:0008088	1/96	axon cargo transport	biological_process	"The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194]
EOG8B8MT2	GO:0005875	1/96	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8B8MT2	GO:0008355	1/96	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8B8MT2	GO:0007528	1/96	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8B8MT2	GO:0007409	1/96	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8B8MT2	GO:0043524	1/96	negative regulation of neuron apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
EOG8B8MT2	GO:0019900	1/96	kinase binding	molecular_function	"Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]
EOG8B8MT2	GO:0008582	1/96	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8B8MT2	GO:0005737	1/96	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8B8MT2	GO:0007017	1/96	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG88971K	GO:0017153	33/151	sodium:dicarboxylate symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]
EOG88971K	GO:0016020	32/151	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG88971K	GO:0015183	1/151	L-aspartate transmembrane transporter activity	molecular_function	"Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
EOG88971K	GO:0005313	1/151	L-glutamate transmembrane transporter activity	molecular_function	"Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG88971K	GO:0005886	1/151	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG88971K	GO:0015501	1/151	glutamate:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1]
EOG88971K	GO:0007268	1/151	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG88971K	GO:0015810	1/151	aspartate transport	biological_process	"The directed movement of aspartate, the anion of aspartic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
EOG88971K	GO:0016021	1/151	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88971K	GO:0043195	1/151	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG88971K	GO:0015813	1/151	L-glutamate transport	biological_process	"The directed movement of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:dph, GOC:tb]
EOG88971K	GO:0008345	1/151	larval locomotory behavior	biological_process	"Locomotory behavior in a larval (immature) organism." [GOC:ai]
EOG88971K	GO:0043005	1/151	neuron projection	cellular_component	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
EOG88971K	GO:0014853	1/151	regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction	biological_process	"Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:ef, GOC:mtg_muscle]
EOG88971K	GO:0008340	1/151	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8FJBRF	GO:0042302	572/1336	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8FJBRF	GO:0040003	37/1336	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8FJBRF	GO:0008010	37/1336	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8FJBRF	GO:0031012	37/1336	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8FJBRF	GO:0005576	13/1336	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8FJBRF	GO:0008363	8/1336	larval chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG8FJBRF	GO:0005215	7/1336	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8FJBRF	GO:0008011	2/1336	structural constituent of pupal chitin-based cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8FJBRF	GO:0005615	1/1336	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8FJBRF	GO:0032504	1/1336	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8FJBRF	GO:0042381	1/1336	hemolymph coagulation	biological_process	"Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949]
EOG8FJBRN	GO:0009987	1/86	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8FJBRN	GO:0046331	1/86	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8P5NQ9	GO:0006281	2/37	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8P5NQ9	GO:0000723	2/37	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8P5NQ9	GO:0003678	2/37	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8P5NQ9	GO:0004386	1/37	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8P5NQ9	GO:0004519	1/37	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8P5NQ0	GO:0007611	1/94	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG8P5NQ0	GO:0005794	1/94	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8P5NQ0	GO:0008355	1/94	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8P5NQ0	GO:0046907	1/94	intracellular transport	biological_process	"The directed movement of substances within a cell." [GOC:ai]
EOG8P5NQ0	GO:0005737	1/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8P5NQ0	GO:0007616	1/94	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8FXTPM	GO:0003824	23/90	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8FXTPM	GO:0004300	3/90	enoyl-CoA hydratase activity	molecular_function	"Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.17]
EOG8FXTPM	GO:0005811	1/90	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8FXTPM	GO:0005875	1/90	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8SR09W	GO:0005634	27/143	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SR09W	GO:0043704	1/143	photoreceptor cell fate specification	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu]
EOG8SR09W	GO:0016319	1/143	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8SR09W	GO:0005515	1/143	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8SR09W	GO:0007483	1/143	genital disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238]
EOG8SR09W	GO:0042051	1/143	compound eye photoreceptor development	biological_process	"The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
EOG8SR09W	GO:0035263	1/143	genital disc sexually dimorphic development	biological_process	"The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781]
EOG8SR09W	GO:0010629	1/143	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8SR09W	GO:0048749	1/143	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8SR09W	GO:0030182	1/143	neuron differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
EOG8SR09W	GO:0007411	1/143	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8SR09W	GO:0006351	1/143	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8SR09W	GO:0007479	1/143	leg disc proximal/distal pattern formation	biological_process	"The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf]
EOG8SR09W	GO:0035215	1/143	genital disc development	biological_process	"Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318]
EOG8SR09W	GO:0035211	1/143	spermathecum morphogenesis	biological_process	"The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097]
EOG8SR09W	GO:0048098	1/143	antennal joint development	biological_process	"The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments." [GOC:jid]
EOG8P5NQ5	GO:0006097	1/99	glyoxylate cycle	biological_process	"A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732]
EOG8P5NQ5	GO:0004474	1/99	malate synthase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+)." [EC:2.3.3.9, RHEA:18184]
EOG8S7N5C	GO:0008080	23/84	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG8S7N5C	GO:0004596	2/84	peptide alpha-N-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [EC:2.3.1.88, GOC:mah]
EOG8S7N5C	GO:0031248	1/84	protein acetyltransferase complex	cellular_component	"A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf]
EOG8S7N5C	GO:0048477	1/84	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8S7N5C	GO:0022008	1/84	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8P2SGC	GO:0046961	2/85	proton-transporting ATPase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]
EOG8P2SGC	GO:0015991	2/85	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8P2SGC	GO:0000221	2/85	vacuolar proton-transporting V-type ATPase, V1 domain	cellular_component	"The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG8P2SGC	GO:0046716	1/85	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG8P2SGC	GO:0042052	1/85	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8P2SGC	GO:1901216	1/85	positive regulation of neuron death	biological_process	"Any process that activates or increases the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]
EOG8P2SGC	GO:0006099	1/85	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8Z0DM5	GO:0046872	27/94	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z0DM5	GO:0070084	25/94	protein initiator methionine removal	biological_process	"The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein." [GOC:imk, GOC:mah]
EOG8Z0DM5	GO:0070006	25/94	metalloaminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8Z0DM5	GO:0005737	25/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Z0DM5	GO:0004177	4/94	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG8Z0DM5	GO:0008235	3/94	metalloexopeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]
EOG8Z0DM5	GO:0016787	1/94	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8C5G1G	GO:0006099	37/104	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8C5G1G	GO:0000104	37/104	succinate dehydrogenase activity	molecular_function	"Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor." [EC:1.3.99.1, GOC:kd]
EOG8C5G1G	GO:0045281	36/104	succinate dehydrogenase complex	cellular_component	"A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones." [GOC:kd, InterPro:IPR000701]
EOG8C5G1G	GO:0009055	26/104	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8C5G1G	GO:0016627	3/104	oxidoreductase activity, acting on the CH-CH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8C5G1G	GO:0006979	1/104	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8C5G1G	GO:0008340	1/104	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8C5G1G	GO:0016020	1/104	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8C5G1G	GO:0006121	1/104	mitochondrial electron transport, succinate to ubiquinone	biological_process	"The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II." [ISBN:0716731363]
EOG88PQ06	GO:0006071	57/142	glycerol metabolic process	biological_process	"The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]
EOG88PQ06	GO:0008889	57/142	glycerophosphodiester phosphodiesterase activity	molecular_function	"Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]
EOG88PQ06	GO:0006629	57/142	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG88PQ06	GO:2001070	51/142	starch binding	molecular_function	"Interacting selectively and non-covalently with starch." [GOC:mengo_curators]
EOG88PQ06	GO:0003676	2/142	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88PQ06	GO:0005615	1/142	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG88PQ06	GO:0046872	1/142	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG88PQ06	GO:0017022	1/142	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG88PQ06	GO:0032504	1/142	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG81C9CD	GO:0003746	4/87	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG81C9CD	GO:0005875	1/87	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG81C9CD	GO:0005515	1/87	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG81C9CD	GO:0070449	1/87	elongin complex	cellular_component	"A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits." [PMID:12676794]
EOG81C9CD	GO:0004045	1/87	aminoacyl-tRNA hydrolase activity	molecular_function	"Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]
EOG81C9CD	GO:0007474	1/87	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG8Z0DM8	GO:0050567	22/104	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	molecular_function	"Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN]
EOG8Z0DM8	GO:0005524	22/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8Z0DM8	GO:0030956	22/104	glutamyl-tRNA(Gln) amidotransferase complex	cellular_component	"A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg]
EOG8Z0DM8	GO:0032543	22/104	mitochondrial translation	biological_process	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]
EOG8Z0DM8	GO:0070681	22/104	glutaminyl-tRNAGln biosynthesis via transamidation	biological_process	"A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921]
EOG8Z0DM8	GO:0005739	22/104	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8Z0DM8	GO:0016884	8/104	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	molecular_function	"Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532]
EOG8Z0DM8	GO:0016740	1/104	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8TB6V2	GO:0000166	25/106	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8TB6V2	GO:0003676	24/106	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8TB6V2	GO:0005634	1/106	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TB6V2	GO:0005849	1/106	mRNA cleavage factor complex	cellular_component	"Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856]
EOG8TB6V2	GO:0000381	1/106	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8TB6V2	GO:0006379	1/106	mRNA cleavage	biological_process	"Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah]
EOG8TB6V2	GO:0003729	1/106	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8P2SGS	GO:0016021	6/204	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8P2SGS	GO:0055085	5/204	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8P2SGS	GO:0005886	1/204	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8P2SGS	GO:0003009	1/204	skeletal muscle contraction	biological_process	"A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle]
EOG89CSRT	GO:0016021	21/71	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88D39Z	GO:0006744	32/131	ubiquinone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]
EOG88D39Z	GO:0008425	32/131	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	molecular_function	"Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048]
EOG88D39Z	GO:0008689	2/131	3-demethylubiquinone-9 3-O-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9." [GOC:dph]
EOG88D39Z	GO:0008757	1/131	S-adenosylmethionine-dependent methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]
EOG88D39Z	GO:0006470	1/131	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG88D39Z	GO:0017017	1/131	MAP kinase tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]
EOG88D39Z	GO:0030798	1/131	trans-aconitate 2-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972]
EOG88D39Z	GO:0042060	1/131	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG88D39Z	GO:0004395	1/131	hexaprenyldihydroxybenzoate methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [EC:2.1.1.114]
EOG8K9DVG	GO:0042073	1/100	intraciliary transport	biological_process	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374]
EOG8K9DVG	GO:0000922	1/100	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8K9DVG	GO:0005875	1/100	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8K9DVG	GO:0005515	1/100	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8K9DVG	GO:0000242	1/100	pericentriolar material	cellular_component	"A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]
EOG8K9DVG	GO:0007279	1/100	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8K9DVG	GO:0005813	1/100	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8K9DVG	GO:0008017	1/100	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8K9DVG	GO:0000235	1/100	astral microtubule	cellular_component	"Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194]
EOG8K9DVG	GO:0007143	1/100	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8K9DVG	GO:0007067	1/100	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8K9DVG	GO:0007097	1/100	nuclear migration	biological_process	"The directed movement of the nucleus." [GOC:ai]
EOG8K9DVG	GO:0007344	1/100	pronuclear fusion	biological_process	"The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X]
EOG8K9DVG	GO:0008104	1/100	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8K9DVG	GO:0005876	1/100	spindle microtubule	cellular_component	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]
EOG8K9DVG	GO:0007052	1/100	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8K9DVG	GO:0007026	1/100	negative regulation of microtubule depolymerization	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]
EOG8K9DVG	GO:0000226	1/100	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8K9DVG	GO:0035046	1/100	pronuclear migration	biological_process	"The directed movement of the male and female pronuclei towards each other prior to their fusion." [GOC:bf, PMID:9199363]
EOG88D39P	GO:0005737	28/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG88D39P	GO:0005094	28/89	Rho GDP-dissociation inhibitor activity	molecular_function	"Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding." [GOC:mah]
EOG8K9DVH	GO:0016746	1/16	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8K9DVH	GO:0004102	1/16	choline O-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA." [EC:2.3.1.6, RHEA:18824]
EOG8K9DVT	GO:0030529	1/42	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8K9DVT	GO:0019013	1/42	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG87WR48	GO:0003676	2/23	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GTNSR	GO:0007165	95/374	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8GTNSR	GO:0016021	55/374	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GTNSR	GO:0004721	6/374	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8GTNSR	GO:0046790	1/374	virion binding	molecular_function	"Interacting selectively and non-covalently with a virion, either by binding to components of the capsid or the viral envelope." [GOC:ai]
EOG8GTNSR	GO:0002227	1/374	innate immune response in mucosa	biological_process	"Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105]
EOG8GTNSR	GO:0006952	1/374	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8GTNSR	GO:0005886	1/374	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8GTNSR	GO:0006955	1/374	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8GTNSR	GO:0002752	1/374	cell surface pattern recognition receptor signaling pathway	biological_process	"Any series of molecular signals generated as a consequence of a cell surface pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
EOG8GTNSR	GO:0010508	1/374	positive regulation of autophagy	biological_process	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8GTNSR	GO:0019731	1/374	antibacterial humoral response	biological_process	"An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8GTNSR	GO:0048598	1/374	embryonic morphogenesis	biological_process	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]
EOG8GTNSR	GO:0009653	1/374	anatomical structure morphogenesis	biological_process	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]
EOG8GTNSR	GO:0004888	1/374	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8GTNSR	GO:0008329	1/374	signaling pattern recognition receptor activity	molecular_function	"Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity." [GOC:ar, PMID:12507420, PMID:12925128, PMID:14523544, Wikipedia:Pattern_recognition_receptor]
EOG8GTNSR	GO:0009897	1/374	external side of plasma membrane	cellular_component	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]
EOG8GTNSR	GO:0060049	1/374	regulation of protein glycosylation	biological_process	"Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr]
EOG8GTNSR	GO:0048935	1/374	peripheral nervous system neuron development	biological_process	"The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh]
EOG8GTNSR	GO:0007275	1/374	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8GTNSR	GO:0050688	1/374	regulation of defense response to virus	biological_process	"Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai]
EOG8GTNSR	GO:0051607	1/374	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG8GTNSR	GO:0007155	1/374	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8GTNSR	GO:0005737	1/374	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WM799	GO:0005840	2/87	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8WM799	GO:0005762	1/87	mitochondrial large ribosomal subunit	cellular_component	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
EOG8WM799	GO:0006412	1/87	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8WM799	GO:0003735	1/87	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8WM799	GO:0016020	1/87	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG825879	GO:0006412	14/77	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG825879	GO:0003735	14/77	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG825879	GO:0005840	13/77	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG825879	GO:0003723	12/77	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG825879	GO:0005763	1/77	mitochondrial small ribosomal subunit	cellular_component	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
EOG8BCH3F	GO:0003700	27/104	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8BCH3F	GO:0005634	26/104	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BCH3F	GO:0000976	19/104	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8BCH3F	GO:0043565	8/104	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8BCH3F	GO:0007411	1/104	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8BCH3F	GO:0004000	1/104	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8BCH3F	GO:0048663	1/104	neuron fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph]
EOG8BZQHM	GO:0016042	1/103	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8BZQHM	GO:0005576	1/103	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8BZQHM	GO:0046843	1/103	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8BZQHM	GO:0002121	1/103	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8BZQHM	GO:0016787	1/103	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8BZQHM	GO:0007444	1/103	imaginal disc development	biological_process	"The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238]
EOG8BZQHH	GO:0004867	3/66	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG8HHRH8	GO:0003677	25/89	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8HHRH8	GO:0006260	24/89	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8HHRH8	GO:0017111	16/89	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8HHRH8	GO:0000166	15/89	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8HHRH8	GO:0022008	1/89	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8HHRH8	GO:0003887	1/89	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8HHRH8	GO:0005524	1/89	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8HHRH8	GO:0005875	1/89	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8FXTNG	GO:0003676	1/106	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8J9QD1	GO:0005524	114/470	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8J9QD1	GO:0003676	87/470	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8J9QD1	GO:0008026	87/470	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8J9QD1	GO:0004674	25/470	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8J9QD1	GO:0005875	3/470	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8J9QD1	GO:0005634	3/470	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8J9QD1	GO:0004712	3/470	protein serine/threonine/tyrosine kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]
EOG8J9QD1	GO:0004672	2/470	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8J9QD1	GO:0003724	2/470	RNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah]
EOG8J9QD1	GO:0000381	2/470	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8J9QD1	GO:0016779	2/470	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG8J9QD1	GO:0008152	2/470	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8J9QD1	GO:0009306	1/470	protein secretion	biological_process	"The controlled release of proteins from a cell." [GOC:ai]
EOG8J9QD1	GO:0007399	1/470	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8J9QD1	GO:0071011	1/470	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8J9QD1	GO:0048477	1/470	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8J9QD1	GO:0009882	1/470	blue light photoreceptor activity	molecular_function	"The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb]
EOG8J9QD1	GO:0005783	1/470	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8J9QD1	GO:0007350	1/470	blastoderm segmentation	biological_process	"The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8J9QD1	GO:0019730	1/470	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG8J9QD1	GO:0007548	1/470	sex differentiation	biological_process	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]
EOG8J9QD1	GO:0030717	1/470	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG8J9QD1	GO:0005737	1/470	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8J9QD1	GO:0007601	1/470	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8J9QD1	GO:0000398	1/470	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8J9QD1	GO:0042051	1/470	compound eye photoreceptor development	biological_process	"The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
EOG8J9QD1	GO:0048749	1/470	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8J9QD1	GO:0048854	1/470	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG8J9QD1	GO:0035071	1/470	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8J9QD1	GO:0031987	1/470	locomotion involved in locomotory behavior	biological_process	"Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
EOG8J9QD1	GO:0048102	1/470	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8J9QD1	GO:0006468	1/470	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8J9QD1	GO:0046777	1/470	protein autophosphorylation	biological_process	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
EOG8J9QD1	GO:0005515	1/470	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8J9QD1	GO:0005703	1/470	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG8J9QD1	GO:0004713	1/470	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8J9QD1	GO:0003729	1/470	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8J9QD1	GO:0016246	1/470	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG8J9QD1	GO:0022008	1/470	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8J9QD1	GO:2000255	1/470	negative regulation of male germ cell proliferation	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation." [GOC:obol]
EOG8J9QD1	GO:0005700	1/470	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8J9QD1	GO:0006417	1/470	regulation of translation	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8J9QD1	GO:0001964	1/470	startle response	biological_process	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
EOG8J9QD1	GO:0004386	1/470	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8J9QD1	GO:0071949	1/470	FAD binding	molecular_function	"Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]
EOG8J9QD1	GO:0071013	1/470	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8J9QD1	GO:0005829	1/470	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8BCH36	GO:0003676	34/97	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BCH36	GO:0004523	31/97	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8BCH36	GO:0000287	9/97	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8BCH36	GO:0090502	1/97	RNA phosphodiester bond hydrolysis, endonucleolytic	biological_process	"The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
EOG8N5ZDH	GO:0004386	1/7	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8N5ZDH	GO:0004519	1/7	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG85B3VX	GO:0003723	4/181	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG85B3VX	GO:0007275	3/181	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG85B3VX	GO:0003676	3/181	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85B3VX	GO:0005737	1/181	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG85B3VX	GO:0007317	1/181	regulation of pole plasm oskar mRNA localization	biological_process	"Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb]
EOG85B3VX	GO:0008595	1/181	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG85B3VX	GO:0001700	1/181	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG85B3VX	GO:0007300	1/181	ovarian nurse cell to oocyte transport	biological_process	"Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG85B3VX	GO:0000398	1/181	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG85B3VX	GO:0045451	1/181	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG85B3VX	GO:0007283	1/181	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG85B3VX	GO:0000932	1/181	cytoplasmic mRNA processing body	cellular_component	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603]
EOG85B3VX	GO:0071011	1/181	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG85B3VX	GO:0046331	1/181	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG85B3VX	GO:0045450	1/181	bicoid mRNA localization	biological_process	"Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators]
EOG83BQ3T	GO:0005215	6/86	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG83BQ3T	GO:0016020	4/86	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG83BQ3T	GO:0016021	2/86	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85B3VT	GO:0016620	25/91	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG85B3VT	GO:0004029	3/91	aldehyde dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]
EOG80ZTFM	GO:0007409	1/126	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG80ZTFM	GO:0022008	1/126	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG82587R	GO:0006457	26/86	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG82587R	GO:0003755	1/86	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG84J51M	GO:0005739	19/59	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8VX4K3	GO:0005524	51/166	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VX4K3	GO:0016887	50/166	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8VX4K3	GO:0015438	1/166	teichoic-acid-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)." [EC:3.6.3.40]
EOG8VX4K3	GO:0015408	1/166	ferric-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [EC:3.6.3.30]
EOG879HNK	GO:0016020	12/75	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG879HNK	GO:0003824	9/75	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG879HNK	GO:0016787	3/75	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8JMB6B	GO:0003676	2/20	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JMB6B	GO:0015074	2/20	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG854CDK	GO:0005024	3/40	transforming growth factor beta-activated receptor activity	molecular_function	"Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]
EOG854CDK	GO:0016020	3/40	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG879HNP	GO:0008241	1/87	peptidyl-dipeptidase activity	molecular_function	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]
EOG879HNP	GO:0016020	1/87	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG879HNP	GO:0008237	1/87	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG80KBDB	GO:0016746	22/105	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG80KBDB	GO:0004095	3/105	carnitine O-palmitoyltransferase activity	molecular_function	"Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21]
EOG80KBDB	GO:0003993	1/105	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG80KBDB	GO:0006979	1/105	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG80KBDB	GO:0010038	1/105	response to metal ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]
EOG80KBDB	GO:0042594	1/105	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG805VF4	GO:0055085	23/108	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG805VF4	GO:0016021	23/108	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V71WJ	GO:0016491	25/79	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8V71WJ	GO:0006546	24/79	glycine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]
EOG8V71WJ	GO:0005737	24/79	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8V71WJ	GO:0004047	24/79	aminomethyltransferase activity	molecular_function	"Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10]
EOG8V71WJ	GO:0016787	1/79	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG805VF1	GO:0016021	26/103	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG805VF1	GO:0000287	26/103	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG805VF1	GO:0004012	26/103	phospholipid-translocating ATPase activity	molecular_function	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684]
EOG805VF1	GO:0005524	26/103	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG805VF1	GO:0019829	24/103	cation-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]
EOG805VF1	GO:0005388	1/103	calcium-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8]
EOG805VF0	GO:0016021	70/329	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG805VF0	GO:0022857	41/329	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG805VF0	GO:0055085	29/329	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG805VF0	GO:0005215	13/329	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG805VF0	GO:0008643	1/329	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG805VF3	GO:0005634	6/60	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG805VF3	GO:0008270	6/60	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG805VF3	GO:0003700	6/60	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG805VF3	GO:0003964	1/60	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG805VF3	GO:0003723	1/60	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8JT2NH	GO:0003677	1/10	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8JT2NH	GO:0008270	1/10	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V71WD	GO:0035253	23/104	ciliary rootlet	cellular_component	"A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [GOC:cilia, PMID:12427867]
EOG8V71WD	GO:0051297	23/104	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8V71WD	GO:0032440	1/104	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8W3W41	GO:0003735	21/63	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8W3W41	GO:0005840	21/63	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8W3W41	GO:0006412	21/63	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8DBWXS	GO:0022008	1/101	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8NW22Z	GO:0016021	69/289	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NW22Z	GO:0004930	45/289	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8NW22Z	GO:0004935	13/289	adrenergic receptor activity	molecular_function	"Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274]
EOG8NW22Z	GO:0005886	11/289	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8NW22Z	GO:0004993	7/289	serotonin receptor activity	molecular_function	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai]
EOG8NW22Z	GO:0043565	4/289	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NW22Z	GO:0004715	4/289	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8NW22Z	GO:0003700	4/289	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NW22Z	GO:0007186	3/289	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8NW22Z	GO:0010579	3/289	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	biological_process	"Any process that increases the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G-protein coupled receptor signaling pathway." [GOC:dph, GOC:signaling, GOC:tb]
EOG8NW22Z	GO:0008227	3/289	G-protein coupled amine receptor activity	molecular_function	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
EOG8NW22Z	GO:0004989	3/289	octopamine receptor activity	molecular_function	"Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [CHEBI:17134, GOC:ai]
EOG8NW22Z	GO:0005887	3/289	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NW22Z	GO:0007189	3/289	adenylate cyclase-activating G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
EOG8NW22Z	GO:0004977	2/289	melanocortin receptor activity	molecular_function	"Combining with melanocortin to initiate a change in cell activity." [GOC:ai]
EOG8NW22Z	GO:0045886	1/289	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8NW22Z	GO:0007188	1/289	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194]
EOG8NW22Z	GO:0045887	1/289	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG805VFS	GO:0016021	217/605	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG805VFS	GO:0005886	209/605	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG805VFS	GO:0050909	202/605	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG805VFS	GO:0008527	21/605	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG805VFS	GO:0050912	8/605	detection of chemical stimulus involved in sensory perception of taste	biological_process	"The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG805VFS	GO:0004930	3/605	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG805VFS	GO:0030425	2/605	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG805VFS	GO:0004984	2/605	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG805VFS	GO:0017085	2/605	response to insecticide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]
EOG805VFS	GO:0030424	2/605	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG805VFS	GO:0007635	2/605	chemosensory behavior	biological_process	"Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators]
EOG805VFS	GO:0005549	2/605	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG805VFS	GO:0046957	1/605	negative phototaxis	biological_process	"The directed movement of a cell or organism away from a source of light." [GOC:ai]
EOG805VFS	GO:0007631	1/605	feeding behavior	biological_process	"Behavior associated with the intake of food." [GOC:mah]
EOG805VFS	GO:0040040	1/605	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG805VFS	GO:0031000	1/605	response to caffeine	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah]
EOG805VFS	GO:0006955	1/605	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG805VFS	GO:0007602	1/605	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG805VFS	GO:0046982	1/605	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG805VFS	GO:0008049	1/605	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG805VFS	GO:0035006	1/605	melanization defense response	biological_process	"The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809]
EOG805VFS	GO:0042742	1/605	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG805VFS	GO:0044297	1/605	cell body	cellular_component	"The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]
EOG8R2689	GO:0008270	25/78	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8R2689	GO:0003676	4/78	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8G1Q08	GO:0005840	28/84	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8G1Q08	GO:0003735	28/84	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8G1Q08	GO:0006412	28/84	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8G1Q08	GO:0046872	24/84	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8G1Q08	GO:0019843	24/84	rRNA binding	molecular_function	"Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl]
EOG8NW22D	GO:0003676	1/48	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V19GG	GO:0007218	1/73	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8V19GG	GO:0005179	1/73	hormone activity	molecular_function	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]
EOG8V19GG	GO:0045968	1/73	negative regulation of juvenile hormone biosynthetic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators]
EOG8V19GG	GO:0005184	1/73	neuropeptide hormone activity	molecular_function	"The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]
EOG8V19GG	GO:0005102	1/73	receptor binding	molecular_function	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]
EOG8V19GG	GO:0071855	1/73	neuropeptide receptor binding	molecular_function	"Interacting selectively and non-covalently with a neuropeptide receptor." [GOC:kmv, GOC:mah]
EOG8V19GG	GO:0005576	1/73	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8V19GF	GO:0008270	26/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V19GF	GO:0022416	1/91	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8V19GF	GO:0035220	1/91	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG80KBD8	GO:0003676	2/43	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80KBD8	GO:0008270	2/43	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VX4KS	GO:0046872	11/348	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8VX4KS	GO:0005737	1/348	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8VX4KS	GO:0010629	1/348	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8VX4KS	GO:0042826	1/348	histone deacetylase binding	molecular_function	"Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl]
EOG8VX4KS	GO:0005634	1/348	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VX4KB	GO:0016324	1/216	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8VX4KB	GO:0005080	1/216	protein kinase C binding	molecular_function	"Interacting selectively and non-covalently with protein kinase C." [GOC:jl]
EOG8VX4KB	GO:0008594	1/216	photoreceptor cell morphogenesis	biological_process	"The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
EOG8VX4KB	GO:0002009	1/216	morphogenesis of an epithelium	biological_process	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
EOG8VX4KB	GO:0035088	1/216	establishment or maintenance of apical/basal cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483]
EOG8VX4KB	GO:0016333	1/216	morphogenesis of follicular epithelium	biological_process	"The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl]
EOG8VX4KB	GO:0016334	1/216	establishment or maintenance of polarity of follicular epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah]
EOG8VX4KB	GO:0035509	1/216	negative regulation of myosin-light-chain-phosphatase activity	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators]
EOG8VX4KB	GO:0005737	1/216	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8VX4KB	GO:0032033	1/216	myosin II light chain binding	molecular_function	"Interacting selectively and non-covalently with a light chain of a myosin II complex." [GOC:mah]
EOG8VX4KB	GO:0005886	1/216	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8VX4KB	GO:0045176	1/216	apical protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf]
EOG8VX4KB	GO:0005918	1/216	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG8VX4KB	GO:0034332	1/216	adherens junction organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah]
EOG8VX4KB	GO:0001736	1/216	establishment of planar polarity	biological_process	"Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
EOG8VX4KB	GO:0016332	1/216	establishment or maintenance of polarity of embryonic epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah]
EOG8VX4KB	GO:0045494	1/216	photoreceptor cell maintenance	biological_process	"Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]
EOG8VX4KB	GO:0005635	1/216	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG8VX4KB	GO:0007163	1/216	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8VX4KB	GO:0035209	1/216	pupal development	biological_process	"The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis." [GOC:bf, GOC:mtg_sensu]
EOG8VX4KB	GO:0005515	1/216	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VX4KB	GO:0016327	1/216	apicolateral plasma membrane	cellular_component	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
EOG8VX4KB	GO:0035003	1/216	subapical complex	cellular_component	"The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938]
EOG8VX4KB	GO:0005875	1/216	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8VX4KB	GO:0007043	1/216	cell-cell junction assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai]
EOG8VX4KB	GO:0005912	1/216	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8VX4KB	GO:0045179	1/216	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8VX4KB	GO:0034334	1/216	adherens junction maintenance	biological_process	"The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah]
EOG8VX4KB	GO:0045186	1/216	zonula adherens assembly	biological_process	"Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf]