GO:0005549	odorant binding	Gains
GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0004518	nuclease activity	Gains
GO:0005242	inward rectifier potassium channel activity	Gains
GO:0015276	ligand-gated ion channel activity	Gains
GO:0022834	ligand-gated channel activity	Gains
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
GO:0022857	transmembrane transporter activity	Gains
GO:0004521	endoribonuclease activity	Gains
GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
GO:0050591	quinine 3-monooxygenase activity	Gains
GO:0004555	alpha,alpha-trehalase activity	Gains
GO:0015927	trehalase activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0099094	ligand-gated cation channel activity	Gains
GO:0008527	taste receptor activity	Gains
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
GO:0005216	ion channel activity	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0005215	transporter activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0015267	channel activity	Gains
GO:0004540	ribonuclease activity	Gains
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
GO:0009055	electron transfer activity	Gains
GO:0022891	substrate-specific transmembrane transporter activity	Gains
GO:0004519	endonuclease activity	Gains
GO:0005249	voltage-gated potassium channel activity	Gains
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Gains
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Gains
GO:0005024	transforming growth factor beta-activated receptor activity	Gains
GO:0004872	receptor activity	Gains
GO:0004527	exonuclease activity	Gains
GO:0005267	potassium channel activity	Gains
GO:0005261	cation channel activity	Gains
GO:0022836	gated channel activity	Gains
GO:0004869	cysteine-type endopeptidase inhibitor activity	Gains
GO:0015179	L-amino acid transmembrane transporter activity	Gains
GO:0005337	nucleoside transmembrane transporter activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0009982	pseudouridine synthase activity	Gains
GO:0015075	ion transmembrane transporter activity	Gains
GO:0070330	aromatase activity	Gains
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
GO:0003990	acetylcholinesterase activity	Gains
GO:0004602	glutathione peroxidase activity	Gains
GO:0004806	triglyceride lipase activity	Gains
GO:0022892	substrate-specific transporter activity	Gains
GO:0046914	transition metal ion binding	Gains
GO:0008324	cation transmembrane transporter activity	Gains
GO:0005506	iron ion binding	Gains
GO:0015280	ligand-gated sodium channel activity	Gains
GO:0004356	glutamate-ammonia ligase activity	Gains
GO:0004359	glutaminase activity	Gains
GO:0015222	serotonin transmembrane transporter activity	Gains
GO:0010314	phosphatidylinositol-5-phosphate binding	Gains
GO:0005436	sodium:phosphate symporter activity	Gains
GO:0004301	epoxide hydrolase activity	Gains
GO:0008251	tRNA-specific adenosine deaminase activity	Gains
GO:0050112	inositol 2-dehydrogenase activity	Gains
GO:0047522	15-oxoprostaglandin 13-oxidase activity	Gains
GO:0018833	DDT-dehydrochlorinase activity	Gains
GO:0046987	N-acetyllactosamine beta-1,3-glucuronosyltransferase activity	Gains
GO:0046988	asioloorosomucoid beta-1,3-glucuronosyltransferase activity	Gains
GO:0046989	galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity	Gains
GO:0050291	sphingosine N-acyltransferase activity	Gains
GO:0005225	volume-sensitive anion channel activity	Gains
GO:0042943	D-amino acid transmembrane transporter activity	Gains
GO:0004791	thioredoxin-disulfide reductase activity	Gains
GO:0004796	thromboxane-A synthase activity	Gains
GO:0016211	ammonia ligase activity	Gains
GO:0045735	nutrient reservoir activity	Gains
GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Gains
GO:0070379	high mobility group box 1 binding	Gains
GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Gains
GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	Gains
GO:0044736	acid-sensing ion channel activity	Gains
GO:0005550	pheromone binding	Gains
GO:0004566	beta-glucuronidase activity	Gains
GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity	Gains
GO:0003919	FMN adenylyltransferase activity	Gains
GO:0004651	polynucleotide 5'-phosphatase activity	Gains
GO:0008084	imaginal disc growth factor receptor binding	Gains
GO:0072320	volume-sensitive chloride channel activity	Gains
GO:0004604	phosphoadenylyl-sulfate reductase (thioredoxin) activity	Gains
GO:0050093	methanol dehydrogenase activity	Gains
GO:0008936	nicotinamidase activity	Gains
GO:0070742	C2H2 zinc finger domain binding	Gains
GO:0036132	13-prostaglandin reductase activity	Gains
GO:0004061	arylformamidase activity	Gains
GO:0015175	neutral amino acid transmembrane transporter activity	Gains
GO:0005329	dopamine transmembrane transporter activity	Gains
GO:0019811	cocaine binding	Gains
GO:0004362	glutathione-disulfide reductase activity	Gains
GO:0016209	antioxidant activity	Gains
GO:0022843	voltage-gated cation channel activity	Gains
GO:0016491	oxidoreductase activity	Gains
GO:0004104	cholinesterase activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0003676	nucleic acid binding	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0140097	catalytic activity, acting on DNA	Losses
GO:0004190	aspartic-type endopeptidase activity	Losses
GO:0070001	aspartic-type peptidase activity	Losses
GO:0003677	DNA binding	Losses
GO:1901363	heterocyclic compound binding	Losses
GO:0097159	organic cyclic compound binding	Losses
GO:0008270	zinc ion binding	Losses
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
GO:0008233	peptidase activity	Losses
GO:0046914	transition metal ion binding	Losses
GO:0004175	endopeptidase activity	Losses
GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
GO:0022890	inorganic cation transmembrane transporter activity	Losses
GO:0008336	gamma-butyrobetaine dioxygenase activity	Losses
GO:0008324	cation transmembrane transporter activity	Losses
GO:0015079	potassium ion transmembrane transporter activity	Losses
GO:0005244	voltage-gated ion channel activity	Losses
GO:0022832	voltage-gated channel activity	Losses
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Losses
GO:0005158	insulin receptor binding	Losses
GO:0005251	delayed rectifier potassium channel activity	Losses
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	Losses
GO:0015075	ion transmembrane transporter activity	Losses
GO:0004518	nuclease activity	Losses
GO:0004129	cytochrome-c oxidase activity	Losses
GO:0004112	cyclic-nucleotide phosphodiesterase activity	Losses
GO:0015002	heme-copper terminal oxidase activity	Losses
GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
GO:0015078	hydrogen ion transmembrane transporter activity	Losses
GO:0005488	binding	Losses
GO:0022857	transmembrane transporter activity	Losses
GO:0004736	pyruvate carboxylase activity	Losses
GO:0022821	potassium ion antiporter activity	Losses
GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
GO:0005267	potassium channel activity	Losses
GO:0046872	metal ion binding	Losses
GO:0015291	secondary active transmembrane transporter activity	Losses
GO:0004519	endonuclease activity	Losses
GO:0043169	cation binding	Losses
GO:0022891	substrate-specific transmembrane transporter activity	Losses
GO:0005452	inorganic anion exchanger activity	Losses
GO:0008241	peptidyl-dipeptidase activity	Losses
GO:0022843	voltage-gated cation channel activity	Losses
GO:0005249	voltage-gated potassium channel activity	Losses
GO:0022804	active transmembrane transporter activity	Losses
GO:0070279	vitamin B6 binding	Losses
GO:0030170	pyridoxal phosphate binding	Losses
GO:0034062	5'-3' RNA polymerase activity	Losses
GO:0097747	RNA polymerase activity	Losses
GO:0003707	steroid hormone receptor activity	Losses
GO:0003676	nucleic acid binding	Extinctions
GO:0034061	DNA polymerase activity	Extinctions
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0008336	gamma-butyrobetaine dioxygenase activity	Extinctions
GO:0016779	nucleotidyltransferase activity	Extinctions
GO:0003677	DNA binding	Extinctions
GO:1901363	heterocyclic compound binding	Extinctions
GO:0097159	organic cyclic compound binding	Extinctions
GO:0005452	inorganic anion exchanger activity	Extinctions
GO:0140097	catalytic activity, acting on DNA	Extinctions
GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating) activity	Extinctions
GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	Extinctions
GO:0005159	insulin-like growth factor receptor binding	Extinctions
GO:0018580	nitronate monooxygenase activity	Extinctions
GO:0004846	urate oxidase activity	Extinctions
GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Extinctions
GO:0018478	malonate-semialdehyde dehydrogenase (acetylating) activity	Extinctions
GO:0050353	trimethyllysine dioxygenase activity	Extinctions
GO:0015291	secondary active transmembrane transporter activity	Extinctions