GO:0003676	nucleic acid binding	Gains
GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:1901363	heterocyclic compound binding	Gains
GO:0097159	organic cyclic compound binding	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0003723	RNA binding	Gains
GO:0005488	binding	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0003677	DNA binding	Gains
GO:0046914	transition metal ion binding	Gains
GO:0008270	zinc ion binding	Gains
GO:0005198	structural molecule activity	Gains
GO:0046872	metal ion binding	Gains
GO:0043169	cation binding	Gains
GO:0046523	S-methyl-5-thioribose-1-phosphate isomerase activity	Gains
GO:0003774	motor activity	Gains
GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Gains
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Gains
GO:0097747	RNA polymerase activity	Gains
GO:0003777	microtubule motor activity	Gains
GO:0034062	5'-3' RNA polymerase activity	Gains
GO:0004482	mRNA (guanine-N7-)-methyltransferase activity	Gains
GO:0003696	satellite DNA binding	Gains
GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
GO:0005201	extracellular matrix structural constituent	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0003887	DNA-directed DNA polymerase activity	Gains
GO:0035251	UDP-glucosyltransferase activity	Gains
GO:0004500	dopamine beta-monooxygenase activity	Gains
GO:0034450	ubiquitin-ubiquitin ligase activity	Gains
GO:0061659	ubiquitin-like protein ligase activity	Gains
GO:0061630	ubiquitin protein ligase activity	Gains
GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	Gains
GO:0019203	carbohydrate phosphatase activity	Gains
GO:0004563	beta-N-acetylhexosaminidase activity	Gains
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0005216	ion channel activity	Losses
GO:0022838	substrate-specific channel activity	Losses
GO:0004984	olfactory receptor activity	Losses
GO:0015267	channel activity	Losses
GO:0022803	passive transmembrane transporter activity	Losses
GO:0005549	odorant binding	Losses
GO:0005261	cation channel activity	Losses
GO:0015075	ion transmembrane transporter activity	Losses
GO:0022857	transmembrane transporter activity	Losses
GO:0022843	voltage-gated cation channel activity	Losses
GO:0022836	gated channel activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0005262	calcium channel activity	Losses
GO:0072509	divalent inorganic cation transmembrane transporter activity	Losses
GO:0022891	substrate-specific transmembrane transporter activity	Losses
GO:0046873	metal ion transmembrane transporter activity	Losses
GO:0008081	phosphoric diester hydrolase activity	Losses
GO:0005215	transporter activity	Losses
GO:0016788	hydrolase activity, acting on ester bonds	Losses
GO:0052745	inositol phosphate phosphatase activity	Losses
GO:0016209	antioxidant activity	Losses
GO:0008934	inositol monophosphate 1-phosphatase activity	Losses
GO:0008445	D-aspartate oxidase activity	Losses
GO:0043874	acireductone synthase activity	Losses
GO:0018685	alkane 1-monooxygenase activity	Losses
GO:0046423	allene-oxide cyclase activity	Losses
GO:0050824	water binding	Losses
GO:0050825	ice binding	Losses
GO:0003884	D-amino-acid oxidase activity	Losses
GO:0052832	inositol monophosphate 3-phosphatase activity	Losses
GO:0052833	inositol monophosphate 4-phosphatase activity	Losses
GO:0052834	inositol monophosphate phosphatase activity	Losses
GO:0047396	glycosylphosphatidylinositol diacylglycerol-lyase activity	Losses
GO:0015922	aspartate oxidase activity	Losses
GO:0019789	SUMO transferase activity	Losses
GO:0030553	cGMP binding	Losses
GO:0005244	voltage-gated ion channel activity	Losses
GO:0022832	voltage-gated channel activity	Losses
GO:0008509	anion transmembrane transporter activity	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0004620	phospholipase activity	Losses
GO:0005506	iron ion binding	Losses
GO:0022890	inorganic cation transmembrane transporter activity	Losses
GO:0016298	lipase activity	Losses
GO:0015276	ligand-gated ion channel activity	Losses
GO:0022834	ligand-gated channel activity	Losses
GO:0022892	substrate-specific transporter activity	Losses
GO:0030246	carbohydrate binding	Losses
GO:0004518	nuclease activity	Losses
GO:0015103	inorganic anion transmembrane transporter activity	Losses
GO:0016491	oxidoreductase activity	Losses
GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
GO:0043754	dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity	Losses
GO:0005385	zinc ion transmembrane transporter activity	Losses
GO:0004950	chemokine receptor activity	Losses
GO:0016530	metallochaperone activity	Losses
GO:0004930	G-protein coupled receptor activity	Losses
GO:0004364	glutathione transferase activity	Losses
GO:0005245	voltage-gated calcium channel activity	Losses
GO:0140102	catalytic activity, acting on a rRNA	Losses
GO:0008649	rRNA methyltransferase activity	Losses
GO:0099600	transmembrane receptor activity	Losses
GO:0008324	cation transmembrane transporter activity	Losses
GO:0140097	catalytic activity, acting on DNA	Losses
GO:0099094	ligand-gated cation channel activity	Losses
GO:0015085	calcium ion transmembrane transporter activity	Losses
GO:0004190	aspartic-type endopeptidase activity	Losses
GO:0070001	aspartic-type peptidase activity	Losses
GO:0004692	cGMP-dependent protein kinase activity	Losses
GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Losses
GO:0004368	glycerol-3-phosphate dehydrogenase activity	Losses
GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Losses
GO:0005217	intracellular ligand-gated ion channel activity	Losses
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	Losses
GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Losses
GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Losses
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	Losses
GO:0004784	superoxide dismutase activity	Losses
GO:0004896	cytokine receptor activity	Losses
GO:0030551	cyclic nucleotide binding	Losses
GO:0005230	extracellular ligand-gated ion channel activity	Losses
GO:0016860	intramolecular oxidoreductase activity	Losses
GO:0015079	potassium ion transmembrane transporter activity	Losses
GO:0004767	sphingomyelin phosphodiesterase activity	Losses
GO:0016853	isomerase activity	Losses
GO:0043225	ATPase-coupled anion transmembrane transporter activity	Losses
GO:0005267	potassium channel activity	Losses
GO:0005272	sodium channel activity	Losses
GO:0005549	odorant binding	Extinctions
GO:0004984	olfactory receptor activity	Extinctions
GO:0008445	D-aspartate oxidase activity	Extinctions
GO:0050824	water binding	Extinctions
GO:0050825	ice binding	Extinctions
GO:0003884	D-amino-acid oxidase activity	Extinctions
GO:0015922	aspartate oxidase activity	Extinctions
GO:0019789	SUMO transferase activity	Extinctions
GO:0140102	catalytic activity, acting on a rRNA	Extinctions
GO:0008649	rRNA methyltransferase activity	Extinctions
GO:0043754	dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity	Extinctions
GO:0005385	zinc ion transmembrane transporter activity	Extinctions
GO:0016530	metallochaperone activity	Extinctions
GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Extinctions
GO:0004368	glycerol-3-phosphate dehydrogenase activity	Extinctions
GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Extinctions
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	Extinctions
GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Extinctions
GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Extinctions
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	Extinctions
GO:0004784	superoxide dismutase activity	Extinctions
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0008081	phosphoric diester hydrolase activity	Extinctions
GO:0016835	carbon-oxygen lyase activity	Extinctions
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	Extinctions
GO:0004322	ferroxidase activity	Extinctions
GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	Extinctions
GO:0008859	exoribonuclease II activity	Extinctions
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	Extinctions
GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity	Extinctions
GO:0004551	nucleotide diphosphatase activity	Extinctions
GO:0016836	hydro-lyase activity	Extinctions
GO:0016433	rRNA (adenine) methyltransferase activity	Extinctions
GO:0032266	phosphatidylinositol-3-phosphate binding	Extinctions