GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0005549	odorant binding	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0038023	signaling receptor activity	Gains
GO:0004872	receptor activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0008527	taste receptor activity	Gains
GO:0022834	ligand-gated channel activity	Gains
GO:0015276	ligand-gated ion channel activity	Gains
GO:0038187	pattern recognition receptor activity	Gains
GO:0008329	signaling pattern recognition receptor activity	Gains
GO:0005216	ion channel activity	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0015267	channel activity	Gains
GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
GO:0022836	gated channel activity	Gains
GO:0004971	AMPA glutamate receptor activity	Gains
GO:0004866	endopeptidase inhibitor activity	Gains
GO:0070330	aromatase activity	Gains
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
GO:0036081	extracellular ammonia-gated ion channel activity	Gains
GO:0017171	serine hydrolase activity	Gains
GO:0099094	ligand-gated cation channel activity	Gains
GO:0005506	iron ion binding	Gains
GO:0008236	serine-type peptidase activity	Gains
GO:0030414	peptidase inhibitor activity	Gains
GO:0004252	serine-type endopeptidase activity	Gains
GO:0005230	extracellular ligand-gated ion channel activity	Gains
GO:0061135	endopeptidase regulator activity	Gains
GO:0001085	RNA polymerase II transcription factor binding	Gains
GO:0003677	DNA binding	Gains
GO:0022824	transmitter-gated ion channel activity	Gains
GO:0022835	transmitter-gated channel activity	Gains
GO:0004970	ionotropic glutamate receptor activity	Gains
GO:0004707	MAP kinase activity	Gains
GO:0004867	serine-type endopeptidase inhibitor activity	Gains
GO:0046914	transition metal ion binding	Gains
GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
GO:0030246	carbohydrate binding	Gains
GO:0030594	neurotransmitter receptor activity	Gains
GO:0004144	diacylglycerol O-acyltransferase activity	Gains
GO:0004736	pyruvate carboxylase activity	Gains
GO:0004989	octopamine receptor activity	Gains
GO:0043169	cation binding	Gains
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
GO:0046872	metal ion binding	Gains
GO:0008066	glutamate receptor activity	Gains
GO:0015645	fatty acid ligase activity	Gains
GO:0004467	long-chain fatty acid-CoA ligase activity	Gains
GO:0001871	pattern binding	Gains
GO:0030247	polysaccharide binding	Gains
GO:0004518	nuclease activity	Gains
GO:0018685	alkane 1-monooxygenase activity	Gains
GO:0008521	acetyl-CoA transporter activity	Gains
GO:1990050	phosphatidic acid transporter activity	Gains
GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters	Gains
GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	Gains
GO:0001872	(1->3)-beta-D-glucan binding	Gains
GO:0016848	carbon-halide lyase activity	Gains
GO:0003939	L-iditol 2-dehydrogenase activity	Gains
GO:0004644	phosphoribosylglycinamide formyltransferase activity	Gains
GO:0001607	neuromedin U receptor activity	Gains
GO:0001092	TFIIA-class transcription factor binding	Gains
GO:0008455	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Gains
GO:0004415	hyalurononglucosaminidase activity	Gains
GO:0042277	peptide binding	Losses
GO:0033218	amide binding	Losses
GO:0008613	diuretic hormone activity	Losses
GO:0017046	peptide hormone binding	Losses
GO:0005509	calcium ion binding	Losses
GO:0005184	neuropeptide hormone activity	Losses
GO:0004872	receptor activity	Losses
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Losses
GO:0019894	kinesin binding	Losses
GO:0019199	transmembrane receptor protein kinase activity	Losses
GO:0098772	molecular function regulator	Losses
GO:0005179	hormone activity	Losses
GO:0016835	carbon-oxygen lyase activity	Losses
GO:0060089	molecular transducer activity	Losses
GO:0004888	transmembrane signaling receptor activity	Losses
GO:0004620	phospholipase activity	Losses
GO:0016788	hydrolase activity, acting on ester bonds	Losses
GO:0099600	transmembrane receptor activity	Losses
GO:0032947	protein complex scaffold activity	Losses
GO:0008252	nucleotidase activity	Losses
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0004623	phospholipase A2 activity	Losses
GO:0004089	carbonate dehydratase activity	Losses
GO:0038023	signaling receptor activity	Losses
GO:0042578	phosphoric ester hydrolase activity	Losses
GO:0016836	hydro-lyase activity	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0004767	sphingomyelin phosphodiesterase activity	Losses
GO:0048018	receptor ligand activity	Losses
GO:0016298	lipase activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0008878	glucose-1-phosphate adenylyltransferase activity	Losses
GO:0016157	sucrose synthase activity	Losses
GO:0035013	myosuppressin receptor activity	Losses
GO:0001222	transcription corepressor binding	Losses
GO:0001226	RNA polymerase II transcription corepressor binding	Losses
GO:0033164	glycolipid 6-alpha-mannosyltransferase activity	Losses
GO:0051425	PTB domain binding	Losses
GO:0008073	ornithine decarboxylase inhibitor activity	Losses
GO:0071861	tachykinin receptor binding	Losses
GO:0004642	phosphoribosylformylglycinamidine synthase activity	Losses
GO:0008929	methylglyoxal synthase activity	Losses
GO:0061778	intracellular chloride channel activity	Losses
GO:0005009	insulin-activated receptor activity	Losses
GO:0043560	insulin receptor substrate binding	Losses
GO:0043559	insulin binding	Losses
GO:0042979	ornithine decarboxylase regulator activity	Losses
GO:0004099	chitin deacetylase activity	Losses
GO:0031370	eukaryotic initiation factor 4G binding	Losses
GO:0047964	glyoxylate reductase activity	Losses
GO:0031473	myosin III binding	Losses
GO:0016034	maleylacetoacetate isomerase activity	Losses
GO:0008196	vitellogenin receptor activity	Losses
GO:0004376	glycolipid mannosyltransferase activity	Losses
GO:0004378	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity	Losses
GO:0015277	kainate selective glutamate receptor activity	Losses
GO:0042165	neurotransmitter binding	Losses
GO:0042166	acetylcholine binding	Losses
GO:0050518	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity	Losses
GO:0030267	glyoxylate reductase (NADP) activity	Losses
GO:0005229	intracellular calcium activated chloride channel activity	Losses
GO:0016499	orexin receptor activity	Losses
GO:0004153	dihydropterin deaminase activity	Losses
GO:0071855	neuropeptide receptor binding	Losses
GO:0015171	amino acid transmembrane transporter activity	Losses
GO:0030234	enzyme regulator activity	Losses
GO:0030545	receptor regulator activity	Losses
GO:0017022	myosin binding	Losses
GO:0038024	cargo receptor activity	Losses
GO:0008081	phosphoric diester hydrolase activity	Losses
GO:0042562	hormone binding	Losses
GO:0004857	enzyme inhibitor activity	Losses
GO:0004871	signal transducer activity	Losses
GO:0052689	carboxylic ester hydrolase activity	Losses
GO:0005184	neuropeptide hormone activity	Extinctions
GO:0008613	diuretic hormone activity	Extinctions
GO:0005179	hormone activity	Extinctions
GO:0019894	kinesin binding	Extinctions
GO:0098772	molecular function regulator	Extinctions
GO:0004623	phospholipase A2 activity	Extinctions
GO:0032947	protein complex scaffold activity	Extinctions
GO:0048018	receptor ligand activity	Extinctions
GO:0052689	carboxylic ester hydrolase activity	Extinctions
GO:0030545	receptor regulator activity	Extinctions
GO:0017022	myosin binding	Extinctions
GO:0004857	enzyme inhibitor activity	Extinctions
GO:0016835	carbon-oxygen lyase activity	Extinctions
GO:0071855	neuropeptide receptor binding	Extinctions
GO:0016788	hydrolase activity, acting on ester bonds	Extinctions
GO:0008878	glucose-1-phosphate adenylyltransferase activity	Extinctions
GO:0016157	sucrose synthase activity	Extinctions
GO:0033164	glycolipid 6-alpha-mannosyltransferase activity	Extinctions
GO:0051425	PTB domain binding	Extinctions
GO:0008073	ornithine decarboxylase inhibitor activity	Extinctions
GO:0071861	tachykinin receptor binding	Extinctions
GO:0004642	phosphoribosylformylglycinamidine synthase activity	Extinctions
GO:0008929	methylglyoxal synthase activity	Extinctions
GO:0005009	insulin-activated receptor activity	Extinctions
GO:0043560	insulin receptor substrate binding	Extinctions
GO:0043559	insulin binding	Extinctions
GO:0042979	ornithine decarboxylase regulator activity	Extinctions
GO:0031370	eukaryotic initiation factor 4G binding	Extinctions
GO:0031473	myosin III binding	Extinctions
GO:0016034	maleylacetoacetate isomerase activity	Extinctions
GO:0008196	vitellogenin receptor activity	Extinctions
GO:0004376	glycolipid mannosyltransferase activity	Extinctions
GO:0004378	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity	Extinctions
GO:0050518	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity	Extinctions
GO:0004153	dihydropterin deaminase activity	Extinctions
GO:0001664	G-protein coupled receptor binding	Extinctions
GO:0042826	histone deacetylase binding	Extinctions
GO:0005096	GTPase activator activity	Extinctions
GO:0016307	phosphatidylinositol phosphate kinase activity	Extinctions