GO:0004984	olfactory receptor activity	Gains
GO:0005549	odorant binding	Gains
GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0003677	DNA binding	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0038023	signaling receptor activity	Gains
GO:0008527	taste receptor activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0003676	nucleic acid binding	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0004803	transposase activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0060089	molecular transducer activity	Gains
GO:0004872	receptor activity	Gains
GO:0048019	receptor antagonist activity	Gains
GO:0030547	receptor inhibitor activity	Gains
GO:0003680	AT DNA binding	Gains
GO:0004736	pyruvate carboxylase activity	Gains
GO:0005249	voltage-gated potassium channel activity	Gains
GO:0000155	phosphorelay sensor kinase activity	Gains
GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
GO:0004673	protein histidine kinase activity	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0004075	biotin carboxylase activity	Gains
GO:0048038	quinone binding	Gains
GO:0005154	epidermal growth factor receptor binding	Gains
GO:0043015	gamma-tubulin binding	Gains
GO:1990837	sequence-specific double-stranded DNA binding	Gains
GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Gains
GO:0061135	endopeptidase regulator activity	Gains
GO:0042802	identical protein binding	Gains
GO:0003690	double-stranded DNA binding	Gains
GO:0045182	translation regulator activity	Gains
GO:0004165	dodecenoyl-CoA delta-isomerase activity	Gains
GO:0019201	nucleotide kinase activity	Gains
GO:0005267	potassium channel activity	Gains
GO:0015035	protein disulfide oxidoreductase activity	Gains
GO:0004089	carbonate dehydratase activity	Gains
GO:0001098	basal transcription machinery binding	Gains
GO:0001099	basal RNA polymerase II transcription machinery binding	Gains
GO:0016755	transferase activity, transferring amino-acyl groups	Gains
GO:0004385	guanylate kinase activity	Gains
GO:0070851	growth factor receptor binding	Gains
GO:0004519	endonuclease activity	Gains
GO:0005244	voltage-gated ion channel activity	Gains
GO:0022832	voltage-gated channel activity	Gains
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Gains
GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Gains
GO:0015002	heme-copper terminal oxidase activity	Gains
GO:0016675	oxidoreductase activity, acting on a heme group of donors	Gains
GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Gains
GO:0004129	cytochrome-c oxidase activity	Gains
GO:0004175	endopeptidase activity	Gains
GO:1901363	heterocyclic compound binding	Gains
GO:0004872	receptor activity	Losses
GO:0060089	molecular transducer activity	Losses
GO:0099600	transmembrane receptor activity	Losses
GO:0008061	chitin binding	Losses
GO:0016801	hydrolase activity, acting on ether bonds	Losses
GO:0004888	transmembrane signaling receptor activity	Losses
GO:0038023	signaling receptor activity	Losses
GO:0005549	odorant binding	Losses
GO:0016803	ether hydrolase activity	Losses
GO:0004930	G-protein coupled receptor activity	Losses
GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
GO:0033961	cis-stilbene-oxide hydrolase activity	Losses
GO:0008236	serine-type peptidase activity	Losses
GO:0004252	serine-type endopeptidase activity	Losses
GO:0017171	serine hydrolase activity	Losses
GO:0005501	retinoid binding	Losses
GO:0099094	ligand-gated cation channel activity	Losses
GO:0004871	signal transducer activity	Losses
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
GO:0019840	isoprenoid binding	Losses
GO:0032450	maltose alpha-glucosidase activity	Losses
GO:0003990	acetylcholinesterase activity	Losses
GO:0090599	alpha-glucosidase activity	Losses
GO:0008233	peptidase activity	Losses
GO:0004497	monooxygenase activity	Losses
GO:0022834	ligand-gated channel activity	Losses
GO:0015276	ligand-gated ion channel activity	Losses
GO:0004027	alcohol sulfotransferase activity	Losses
GO:0004997	thyrotropin-releasing hormone receptor activity	Losses
GO:0033932	1,3-alpha-L-fucosidase activity	Losses
GO:0004946	bombesin receptor activity	Losses
GO:0008477	purine nucleosidase activity	Losses
GO:0008160	protein tyrosine phosphatase activator activity	Losses
GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity	Losses
GO:0004371	glycerone kinase activity	Losses
GO:0004321	fatty-acyl-CoA synthase activity	Losses
GO:0004304	estrone sulfotransferase activity	Losses
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Losses
GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Losses
GO:0051721	protein phosphatase 2A binding	Losses
GO:0004167	dopachrome isomerase activity	Losses
GO:0042654	ecdysis-triggering hormone receptor activity	Losses
GO:0047522	15-oxoprostaglandin 13-oxidase activity	Losses
GO:0046920	alpha-(1->3)-fucosyltransferase activity	Losses
GO:0008836	diaminopimelate decarboxylase activity	Losses
GO:0004100	chitin synthase activity	Losses
GO:0019211	phosphatase activator activity	Losses
GO:0061542	3-demethylubiquinone-n 3-O-methyltransferase activity	Losses
GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity	Losses
GO:0016918	retinal binding	Losses
GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
GO:0042947	glucoside transmembrane transporter activity	Losses
GO:0015280	ligand-gated sodium channel activity	Losses
GO:0004556	alpha-amylase activity	Losses
GO:0004586	ornithine decarboxylase activity	Losses
GO:0072542	protein phosphatase activator activity	Losses
GO:0004517	nitric-oxide synthase activity	Losses
GO:0052852	very-long-chain-(S)-2-hydroxy-acid oxidase activity	Losses
GO:0052853	long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity	Losses
GO:0052854	medium-chain-(S)-2-hydroxy-acid oxidase activity	Losses
GO:0003973	(S)-2-hydroxy-acid oxidase activity	Losses
GO:0044736	acid-sensing ion channel activity	Losses
GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Losses
GO:0016499	orexin receptor activity	Losses
GO:0036132	13-prostaglandin reductase activity	Losses
GO:0016160	amylase activity	Losses
GO:0010420	polyprenyldihydroxybenzoate methyltransferase activity	Losses
GO:0015574	trehalose transmembrane transporter activity	Losses
GO:0004062	aryl sulfotransferase activity	Losses
GO:0030247	polysaccharide binding	Losses
GO:0004104	cholinesterase activity	Losses
GO:0008559	xenobiotic transmembrane transporting ATPase activity	Losses
GO:0042910	xenobiotic transmembrane transporter activity	Losses
GO:0001871	pattern binding	Losses
GO:0004175	endopeptidase activity	Losses
GO:0015926	glucosidase activity	Losses
GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
GO:0010181	FMN binding	Losses
GO:0005549	odorant binding	Extinctions
GO:0008061	chitin binding	Extinctions
GO:0004930	G-protein coupled receptor activity	Extinctions
GO:0099600	transmembrane receptor activity	Extinctions
GO:0008236	serine-type peptidase activity	Extinctions
GO:0017171	serine hydrolase activity	Extinctions
GO:0004252	serine-type endopeptidase activity	Extinctions
GO:0004888	transmembrane signaling receptor activity	Extinctions
GO:0004872	receptor activity	Extinctions
GO:0008477	purine nucleosidase activity	Extinctions
GO:0008160	protein tyrosine phosphatase activator activity	Extinctions
GO:0004371	glycerone kinase activity	Extinctions
GO:0051721	protein phosphatase 2A binding	Extinctions
GO:0047522	15-oxoprostaglandin 13-oxidase activity	Extinctions
GO:0019211	phosphatase activator activity	Extinctions
GO:0072542	protein phosphatase activator activity	Extinctions
GO:0036132	13-prostaglandin reductase activity	Extinctions
GO:0060089	molecular transducer activity	Extinctions
GO:0038023	signaling receptor activity	Extinctions
GO:0016084	myostimulatory hormone activity	Extinctions
GO:0004862	cAMP-dependent protein kinase inhibitor activity	Extinctions