GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0046914	transition metal ion binding	Gains
GO:0004175	endopeptidase activity	Gains
GO:0008233	peptidase activity	Gains
GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
GO:0008270	zinc ion binding	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0046872	metal ion binding	Gains
GO:0004298	threonine-type endopeptidase activity	Gains
GO:0070003	threonine-type peptidase activity	Gains
GO:0043169	cation binding	Gains
GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
GO:0004521	endoribonuclease activity	Gains
GO:0004842	ubiquitin-protein transferase activity	Gains
GO:0004519	endonuclease activity	Gains
GO:0005198	structural molecule activity	Gains
GO:0019787	ubiquitin-like protein transferase activity	Gains
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
GO:0046920	alpha-(1->3)-fucosyltransferase activity	Gains
GO:0004890	GABA-A receptor activity	Gains
GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Gains
GO:0004867	serine-type endopeptidase inhibitor activity	Gains
GO:0031418	L-ascorbic acid binding	Gains
GO:0031545	peptidyl-proline 4-dioxygenase activity	Gains
GO:0019798	procollagen-proline dioxygenase activity	Gains
GO:0004656	procollagen-proline 4-dioxygenase activity	Gains
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Gains
GO:0004866	endopeptidase inhibitor activity	Gains
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Gains
GO:0048029	monosaccharide binding	Gains
GO:0005506	iron ion binding	Gains
GO:0031543	peptidyl-proline dioxygenase activity	Gains
GO:0003990	acetylcholinesterase activity	Gains
GO:0061135	endopeptidase regulator activity	Gains
GO:0140096	catalytic activity, acting on a protein	Gains
GO:0005549	odorant binding	Gains
GO:0038023	signaling receptor activity	Gains
GO:0003723	RNA binding	Gains
GO:0001103	RNA polymerase II repressing transcription factor binding	Gains
GO:0004540	ribonuclease activity	Gains
GO:0019842	vitamin binding	Gains
GO:0003676	nucleic acid binding	Gains
GO:0030246	carbohydrate binding	Gains
GO:0031406	carboxylic acid binding	Gains
GO:0043177	organic acid binding	Gains
GO:0004104	cholinesterase activity	Gains
GO:0051213	dioxygenase activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0030414	peptidase inhibitor activity	Gains
GO:0004176	ATP-dependent peptidase activity	Gains
GO:0004687	myosin light chain kinase activity	Gains
GO:0047915	ganglioside galactosyltransferase activity	Gains
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Gains
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Gains
GO:0016881	acid-amino acid ligase activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0004518	nuclease activity	Gains
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
GO:0004872	receptor activity	Gains
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
GO:0004705	JUN kinase activity	Losses
GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
GO:0050591	quinine 3-monooxygenase activity	Losses
GO:0016909	SAP kinase activity	Losses
GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Losses
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	Losses
GO:0016174	NAD(P)H oxidase activity	Losses
GO:0004971	AMPA glutamate receptor activity	Losses
GO:0004806	triglyceride lipase activity	Losses
GO:0004707	MAP kinase activity	Losses
GO:0004602	glutathione peroxidase activity	Losses
GO:0015276	ligand-gated ion channel activity	Losses
GO:0022834	ligand-gated channel activity	Losses
GO:0004869	cysteine-type endopeptidase inhibitor activity	Losses
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
GO:0070330	aromatase activity	Losses
GO:0016491	oxidoreductase activity	Losses
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
GO:0004601	peroxidase activity	Losses
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Losses
GO:0003837	beta-ureidopropionase activity	Losses
GO:0004796	thromboxane-A synthase activity	Losses
GO:0047696	beta-adrenergic receptor kinase activity	Losses
GO:0004747	ribokinase activity	Losses
GO:0018833	DDT-dehydrochlorinase activity	Losses
GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity	Losses
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
GO:0070611	histone methyltransferase activity (H3-R2 specific)	Losses
GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
GO:0008048	calcium sensitive guanylate cyclase activator activity	Losses
GO:0004097	catechol oxidase activity	Losses
GO:0010851	cyclase regulator activity	Losses
GO:0010853	cyclase activator activity	Losses
GO:0004014	adenosylmethionine decarboxylase activity	Losses
GO:0042165	neurotransmitter binding	Losses
GO:0042166	acetylcholine binding	Losses
GO:0008331	high voltage-gated calcium channel activity	Losses
GO:0008420	CTD phosphatase activity	Losses
GO:0030250	guanylate cyclase activator activity	Losses
GO:0030249	guanylate cyclase regulator activity	Losses
GO:0036263	L-DOPA monooxygenase activity	Losses
GO:0036264	dopamine monooxygenase activity	Losses
GO:0005436	sodium:phosphate symporter activity	Losses
GO:0004499	N,N-dimethylaniline monooxygenase activity	Losses
GO:0070410	co-SMAD binding	Losses
GO:0003867	4-aminobutyrate transaminase activity	Losses
GO:0008559	xenobiotic transmembrane transporting ATPase activity	Losses
GO:0042910	xenobiotic transmembrane transporter activity	Losses
GO:0022836	gated channel activity	Losses
GO:0005549	odorant binding	Losses
GO:0003993	acid phosphatase activity	Losses
GO:0016615	malate dehydrogenase activity	Losses
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
GO:0004705	JUN kinase activity	Extinctions
GO:0016909	SAP kinase activity	Extinctions
GO:0004707	MAP kinase activity	Extinctions
GO:0008061	chitin binding	Extinctions
GO:0003837	beta-ureidopropionase activity	Extinctions
GO:0047696	beta-adrenergic receptor kinase activity	Extinctions
GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity	Extinctions
GO:0070611	histone methyltransferase activity (H3-R2 specific)	Extinctions
GO:0004014	adenosylmethionine decarboxylase activity	Extinctions
GO:0008420	CTD phosphatase activity	Extinctions
GO:0003867	4-aminobutyrate transaminase activity	Extinctions
GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity	Extinctions
GO:0008026	ATP-dependent helicase activity	Extinctions
GO:0070035	purine NTP-dependent helicase activity	Extinctions
GO:0016992	lipoate synthase activity	Extinctions
GO:0070283	radical SAM enzyme activity	Extinctions
GO:0016979	lipoate-protein ligase activity	Extinctions
GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Extinctions
GO:0046923	ER retention sequence binding	Extinctions
GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity	Extinctions
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Extinctions
GO:0000702	oxidized base lesion DNA N-glycosylase activity	Extinctions
GO:0061731	ribonucleoside-diphosphate reductase activity	Extinctions
GO:0030331	estrogen receptor binding	Extinctions
GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	Extinctions
GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Extinctions
GO:0004478	methionine adenosyltransferase activity	Extinctions
GO:0004446	inositol-hexakisphosphate phosphatase activity	Extinctions
GO:0004806	triglyceride lipase activity	Extinctions
GO:0005057	signal transducer activity, downstream of receptor	Extinctions
GO:0008301	DNA binding, bending	Extinctions
GO:0019104	DNA N-glycosylase activity	Extinctions
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	Extinctions
GO:0016277	[myelin basic protein]-arginine N-methyltransferase activity	Extinctions
GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	Extinctions
GO:0004035	alkaline phosphatase activity	Extinctions
GO:0005549	odorant binding	Extinctions