GO:0000156 phosphorelay response regulator activity Gains GO:0048037 cofactor binding Gains GO:0030170 pyridoxal phosphate binding Gains GO:0070279 vitamin B6 binding Gains GO:0019842 vitamin binding Gains GO:0016614 oxidoreductase activity, acting on CH-OH group of donors Gains GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Gains GO:0051539 4 iron, 4 sulfur cluster binding Gains GO:0016829 lyase activity Gains GO:0046906 tetrapyrrole binding Gains GO:0016491 oxidoreductase activity Gains GO:0016783 sulfurtransferase activity Gains GO:0016774 phosphotransferase activity, carboxyl group as acceptor Gains GO:0020037 heme binding Gains GO:0050662 coenzyme binding Gains GO:0097159 organic cyclic compound binding Gains GO:1901363 heterocyclic compound binding Gains GO:0003824 catalytic activity Gains GO:0004871 signal transducer activity Gains GO:0005549 odorant binding Gains GO:0005201 extracellular matrix structural constituent Gains GO:0008113 peptide-methionine (S)-S-oxide reductase activity Gains GO:0008460 dTDP-glucose 4,6-dehydratase activity Gains GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity Gains GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity Gains GO:0052739 phosphatidylserine 1-acylhydrolase activity Gains GO:0042083 5,10-methylenetetrahydrofolate-dependent methyltransferase activity Gains GO:0031419 cobalamin binding Gains GO:0005550 pheromone binding Gains GO:0008970 phosphatidylcholine 1-acylhydrolase activity Gains GO:0004497 monooxygenase activity Gains GO:0004930 G-protein coupled receptor activity Gains GO:0030246 carbohydrate binding Gains GO:0016782 transferase activity, transferring sulfur-containing groups Gains GO:0036094 small molecule binding Gains GO:0043168 anion binding Gains GO:0008762 UDP-N-acetylmuramate dehydrogenase activity Gains GO:0008061 chitin binding Gains GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Gains GO:0004673 protein histidine kinase activity Gains GO:0004312 fatty acid synthase activity Gains GO:0019202 amino acid kinase activity Gains GO:0008172 S-methyltransferase activity Gains GO:0005506 iron ion binding Gains GO:0008483 transaminase activity Gains GO:0016769 transferase activity, transferring nitrogenous groups Gains GO:0004812 aminoacyl-tRNA ligase activity Gains GO:0008171 O-methyltransferase activity Gains GO:0016835 carbon-oxygen lyase activity Gains GO:0016775 phosphotransferase activity, nitrogenous group as acceptor Gains GO:0016854 racemase and epimerase activity Gains GO:0016453 C-acetyltransferase activity Gains GO:0016842 amidine-lyase activity Gains GO:0016838 carbon-oxygen lyase activity, acting on phosphates Gains GO:0033743 peptide-methionine (R)-S-oxide reductase activity Gains GO:0016500 protein-hormone receptor activity Gains GO:0008658 penicillin binding Gains GO:0051287 NAD binding Gains GO:0140101 catalytic activity, acting on a tRNA Gains GO:0016798 hydrolase activity, acting on glycosyl bonds Gains GO:0097367 carbohydrate derivative binding Gains GO:0003964 RNA-directed DNA polymerase activity Losses GO:0046914 transition metal ion binding Losses GO:0034061 DNA polymerase activity Losses GO:0008812 choline dehydrogenase activity Losses GO:0004344 glucose dehydrogenase activity Losses GO:0008270 zinc ion binding Losses GO:0016531 copper chaperone activity Losses GO:0140097 catalytic activity, acting on DNA Losses GO:0035250 UDP-galactosyltransferase activity Losses GO:0004526 ribonuclease P activity Losses GO:0008234 cysteine-type peptidase activity Losses GO:0004540 ribonuclease activity Losses GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters Losses GO:0046592 polyamine oxidase activity Losses GO:0016530 metallochaperone activity Losses GO:0022857 transmembrane transporter activity Losses GO:0046872 metal ion binding Losses GO:0005215 transporter activity Losses GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters Losses GO:0016779 nucleotidyltransferase activity Losses GO:0008378 galactosyltransferase activity Losses GO:0004198 calcium-dependent cysteine-type endopeptidase activity Losses GO:0043169 cation binding Losses GO:0004519 endonuclease activity Losses GO:0004190 aspartic-type endopeptidase activity Losses GO:0070001 aspartic-type peptidase activity Losses GO:0008188 neuropeptide receptor activity Losses GO:0004518 nuclease activity Losses GO:0004521 endoribonuclease activity Losses GO:0004549 tRNA-specific ribonuclease activity Losses GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed Losses GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor Losses GO:0016015 morphogen activity Losses GO:0008061 chitin binding Losses GO:0008528 G-protein coupled peptide receptor activity Losses GO:0022892 substrate-specific transporter activity Losses GO:0005507 copper ion binding Losses GO:0016772 transferase activity, transferring phosphorus-containing groups Losses GO:0001653 peptide receptor activity Losses GO:0016790 thiolester hydrolase activity Losses GO:0140103 catalytic activity, acting on a glycoprotein Losses GO:0022891 substrate-specific transmembrane transporter activity Losses GO:0004784 superoxide dismutase activity Losses GO:0016721 oxidoreductase activity, acting on superoxide radicals as acceptor Losses GO:0140104 molecular carrier activity Losses GO:0045296 cadherin binding Losses GO:0016531 copper chaperone activity Extinctions GO:0004526 ribonuclease P activity Extinctions GO:0016530 metallochaperone activity Extinctions GO:0034061 DNA polymerase activity Extinctions GO:0004549 tRNA-specific ribonuclease activity Extinctions GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters Extinctions GO:0003964 RNA-directed DNA polymerase activity Extinctions GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed Extinctions GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters Extinctions GO:0046914 transition metal ion binding Extinctions GO:0008061 chitin binding Extinctions GO:0140104 molecular carrier activity Extinctions GO:0016779 nucleotidyltransferase activity Extinctions GO:0008270 zinc ion binding Extinctions GO:0140097 catalytic activity, acting on DNA Extinctions GO:0004540 ribonuclease activity Extinctions GO:0008568 microtubule-severing ATPase activity Extinctions GO:0016499 orexin receptor activity Extinctions GO:0019784 NEDD8-specific protease activity Extinctions GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity Extinctions GO:0034452 dynactin binding Extinctions GO:0005125 cytokine activity Extinctions GO:0010385 double-stranded methylated DNA binding Extinctions GO:0016532 superoxide dismutase copper chaperone activity Extinctions GO:0072586 DNA topoisomerase (ATP-hydrolyzing) regulator activity Extinctions GO:0072587 DNA topoisomerase (ATP-hydrolyzing) activator activity Extinctions GO:0004666 prostaglandin-endoperoxide synthase activity Extinctions GO:0008084 imaginal disc growth factor receptor binding Extinctions GO:0030586 [methionine synthase] reductase activity Extinctions GO:0004371 glycerone kinase activity Extinctions GO:0016722 oxidoreductase activity, oxidizing metal ions Extinctions GO:1990939 ATP-dependent microtubule motor activity Extinctions