GO:0003700	DNA binding transcription factor activity	Gains
GO:0140110	transcription regulator activity	Gains
GO:0019992	diacylglycerol binding	Gains
GO:0004372	glycine hydroxymethyltransferase activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0090079	translation regulator activity, nucleic acid binding	Gains
GO:0000900	translation repressor activity, nucleic acid binding	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0016832	aldehyde-lyase activity	Gains
GO:0004872	receptor activity	Gains
GO:0030371	translation repressor activity	Gains
GO:0038023	signaling receptor activity	Gains
GO:0045182	translation regulator activity	Gains
GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	Gains
GO:0003730	mRNA 3'-UTR binding	Gains
GO:0043565	sequence-specific DNA binding	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0004550	nucleoside diphosphate kinase activity	Gains
GO:0008270	zinc ion binding	Gains
GO:0046914	transition metal ion binding	Gains
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0004935	adrenergic receptor activity	Gains
GO:0004359	glutaminase activity	Gains
GO:0047325	inositol tetrakisphosphate 1-kinase activity	Gains
GO:0005275	amine transmembrane transporter activity	Gains
GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Gains
GO:0052725	inositol-1,3,4-trisphosphate 6-kinase activity	Gains
GO:0052726	inositol-1,3,4-trisphosphate 5-kinase activity	Gains
GO:0035368	selenocysteine insertion sequence binding	Gains
GO:0052852	very-long-chain-(S)-2-hydroxy-acid oxidase activity	Gains
GO:0052853	long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity	Gains
GO:0052854	medium-chain-(S)-2-hydroxy-acid oxidase activity	Gains
GO:0018271	biotin-protein ligase activity	Gains
GO:0051011	microtubule minus-end binding	Gains
GO:0051018	protein kinase A binding	Gains
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	Gains
GO:0033192	calmodulin-dependent protein phosphatase activity	Gains
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	Gains
GO:0004735	pyrroline-5-carboxylate reductase activity	Gains
GO:0003973	(S)-2-hydroxy-acid oxidase activity	Gains
GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Gains
GO:0008999	ribosomal-protein-alanine N-acetyltransferase activity	Gains
GO:0035226	glutamate-cysteine ligase catalytic subunit binding	Gains
GO:0072586	DNA topoisomerase (ATP-hydrolyzing) regulator activity	Gains
GO:0072587	DNA topoisomerase (ATP-hydrolyzing) activator activity	Gains
GO:0005009	insulin-activated receptor activity	Gains
GO:0033878	hormone-sensitive lipase activity	Gains
GO:0051425	PTB domain binding	Gains
GO:0034185	apolipoprotein binding	Gains
GO:0031151	histone methyltransferase activity (H3-K79 specific)	Gains
GO:0097109	neuroligin family protein binding	Gains
GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity	Gains
GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	Gains
GO:0005368	taurine transmembrane transporter activity	Gains
GO:0005369	taurine:sodium symporter activity	Gains
GO:0043560	insulin receptor substrate binding	Gains
GO:0004019	adenylosuccinate synthase activity	Gains
GO:0043559	insulin binding	Gains
GO:0005463	UDP-N-acetylgalactosamine transmembrane transporter activity	Gains
GO:0005430	synaptic vesicle amine transmembrane transporter activity	Gains
GO:0008117	sphinganine-1-phosphate aldolase activity	Gains
GO:0032454	histone demethylase activity (H3-K9 specific)	Gains
GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0008061	chitin binding	Losses
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Losses
GO:0030247	polysaccharide binding	Losses
GO:0001871	pattern binding	Losses
GO:0008121	ubiquinol-cytochrome-c reductase activity	Losses
GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Losses
GO:0004984	olfactory receptor activity	Losses
GO:0008010	structural constituent of chitin-based larval cuticle	Losses
GO:0005549	odorant binding	Losses
GO:0009055	electron transfer activity	Losses
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0015078	hydrogen ion transmembrane transporter activity	Losses
GO:0016491	oxidoreductase activity	Losses
GO:0005214	structural constituent of chitin-based cuticle	Losses
GO:0008233	peptidase activity	Losses
GO:0038187	pattern recognition receptor activity	Losses
GO:0008329	signaling pattern recognition receptor activity	Losses
GO:0003954	NADH dehydrogenase activity	Losses
GO:0004175	endopeptidase activity	Losses
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Losses
GO:0005215	transporter activity	Losses
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0008376	acetylgalactosaminyltransferase activity	Losses
GO:0019104	DNA N-glycosylase activity	Losses
GO:0004738	pyruvate dehydrogenase activity	Losses
GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	Losses
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	Losses
GO:0016860	intramolecular oxidoreductase activity	Losses
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Losses
GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
GO:0060089	molecular transducer activity	Losses
GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
GO:0003735	structural constituent of ribosome	Losses
GO:0008081	phosphoric diester hydrolase activity	Losses
GO:0022857	transmembrane transporter activity	Losses
GO:0004983	neuropeptide Y receptor activity	Losses
GO:0042834	peptidoglycan binding	Losses
GO:0004619	phosphoglycerate mutase activity	Losses
GO:0031409	pigment binding	Losses
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Losses
GO:0008137	NADH dehydrogenase (ubiquinone) activity	Losses
GO:0050136	NADH dehydrogenase (quinone) activity	Losses
GO:0004872	receptor activity	Losses
GO:0042302	structural constituent of cuticle	Losses
GO:0038024	cargo receptor activity	Losses
GO:0015035	protein disulfide oxidoreductase activity	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0004190	aspartic-type endopeptidase activity	Losses
GO:0070001	aspartic-type peptidase activity	Losses
GO:0070330	aromatase activity	Losses
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Losses
GO:0005201	extracellular matrix structural constituent	Losses
GO:0003723	RNA binding	Losses
GO:0001158	enhancer sequence-specific DNA binding	Losses
GO:0035326	enhancer binding	Losses
GO:0016651	oxidoreductase activity, acting on NAD(P)H	Losses
GO:0008061	chitin binding	Extinctions
GO:0003954	NADH dehydrogenase activity	Extinctions
GO:0004984	olfactory receptor activity	Extinctions
GO:0005549	odorant binding	Extinctions
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Extinctions
GO:0008137	NADH dehydrogenase (ubiquinone) activity	Extinctions
GO:0050136	NADH dehydrogenase (quinone) activity	Extinctions
GO:0016651	oxidoreductase activity, acting on NAD(P)H	Extinctions
GO:0004983	neuropeptide Y receptor activity	Extinctions
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Extinctions
GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
GO:0015035	protein disulfide oxidoreductase activity	Extinctions
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Extinctions
GO:0003735	structural constituent of ribosome	Extinctions
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Extinctions
GO:0015036	disulfide oxidoreductase activity	Extinctions
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Extinctions
GO:0034512	box C/D snoRNA binding	Extinctions
GO:0008725	DNA-3-methyladenine glycosylase activity	Extinctions
GO:0043916	DNA-7-methylguanine glycosylase activity	Extinctions
GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	Extinctions
GO:0004170	dUTP diphosphatase activity	Extinctions
GO:0042284	sphingolipid delta-4 desaturase activity	Extinctions
GO:0052821	DNA-7-methyladenine glycosylase activity	Extinctions
GO:0052822	DNA-3-methylguanine glycosylase activity	Extinctions
GO:0005545	1-phosphatidylinositol binding	Extinctions
GO:0001735	prenylcysteine oxidase activity	Extinctions
GO:0004581	dolichyl-phosphate beta-glucosyltransferase activity	Extinctions
GO:0004512	inositol-3-phosphate synthase activity	Extinctions
GO:0046976	histone methyltransferase activity (H3-K27 specific)	Extinctions
GO:0005041	low-density lipoprotein receptor activity	Extinctions
GO:0003905	alkylbase DNA N-glycosylase activity	Extinctions
GO:0008903	hydroxypyruvate isomerase activity	Extinctions
GO:0035755	cardiolipin hydrolase activity	Extinctions
GO:0043733	DNA-3-methylbase glycosylase activity	Extinctions
GO:0042071	leucokinin receptor activity	Extinctions
GO:0004060	arylamine N-acetyltransferase activity	Extinctions
GO:0004059	aralkylamine N-acetyltransferase activity	Extinctions
GO:0004994	somatostatin receptor activity	Extinctions
GO:0016872	intramolecular lyase activity	Extinctions
GO:0004985	opioid receptor activity	Extinctions
GO:0034722	gamma-glutamyl-peptidase activity	Extinctions
GO:0019153	protein-disulfide reductase (glutathione) activity	Extinctions
GO:0004576	oligosaccharyl transferase activity	Extinctions
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	Extinctions
GO:0008121	ubiquinol-cytochrome-c reductase activity	Extinctions
GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Extinctions