EOG8DV82X	GO:0016020	22/105	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8DV82X	GO:0016021	2/105	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DV82X	GO:0004190	1/105	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8DV82X	GO:0004518	1/105	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8DV82X	GO:0003677	1/105	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XPSZV	GO:0003677	197/409	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XPSZV	GO:0000786	197/409	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8XPSZV	GO:0006334	197/409	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8XPSZV	GO:0005634	196/409	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XPSZV	GO:0032008	25/409	positive regulation of TOR signaling	biological_process	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8XPSZV	GO:0071230	25/409	cellular response to amino acid stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:mah]
EOG8XPSZV	GO:0032439	22/409	endosome localization	biological_process	"Any process in which endosomes are transported to, and/or maintained in, a specific location within the cell." [GOC:ecd]
EOG8XPSZV	GO:0007040	22/409	lysosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]
EOG8XPSZV	GO:0001919	22/409	regulation of receptor recycling	biological_process	"Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add]
EOG8XPSZV	GO:0071986	22/409	Ragulator complex	cellular_component	"A protein complex that contains MAPKSP1 (MP1, Map2k1ip1), ROBLD3 (p14, Mapbpip), C11orf59 (p18), LAMTOR4 and LAMTOR5. The complex is anchored to lipid rafts in late endosome membranes via C11orf59, recruits mTORC1 to lysosomal membranes in amino acid signaling to mTORC1, constitutes a guanine nucleotide exchange factor (GEF) for the Rag GTPases, and is also involved in ERK/MAPK signaling." [GOC:lb, PMID:19177150, PMID:20381137, PMID:22980980]
EOG8XPSZV	GO:0042632	22/409	cholesterol homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]
EOG8XPSZV	GO:0043410	22/409	positive regulation of MAPK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]
EOG8XPSZV	GO:0031902	3/409	late endosome membrane	cellular_component	"The lipid bilayer surrounding a late endosome." [GOC:pz]
EOG8XPSZV	GO:0003964	1/409	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8XPSZV	GO:0003723	1/409	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8XPSZJ	GO:0004129	51/145	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8XPSZJ	GO:0005751	51/145	mitochondrial respiratory chain complex IV	cellular_component	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]
EOG8XPSZJ	GO:0008340	1/145	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8XPSZJ	GO:0005811	1/145	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8XPSZJ	GO:0006123	1/145	mitochondrial electron transport, cytochrome c to oxygen	biological_process	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]
EOG8XPSZJ	GO:0050790	1/145	regulation of catalytic activity	biological_process	"Any process that modulates the activity of an enzyme." [GOC:ai]
EOG8XPSZJ	GO:1902600	1/145	hydrogen ion transmembrane transport	biological_process	"The directed movement of hydrogen ion (proton) across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
EOG8XPSZJ	GO:0030234	1/145	enzyme regulator activity	molecular_function	"Binds to and modulates the activity of an enzyme." [GOC:mah]
EOG8WDGVN	GO:0003677	8/32	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8WDGVN	GO:0003682	4/32	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8DV82M	GO:0006281	5/13	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8DV82M	GO:0003684	5/13	damaged DNA binding	molecular_function	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
EOG8DV82M	GO:0003887	5/13	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8XSP5M	GO:0003676	24/83	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XSP5M	GO:0000213	23/83	tRNA-intron endonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9]
EOG8XSP5M	GO:0006388	18/83	tRNA splicing, via endonucleolytic cleavage and ligation	biological_process	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]
EOG8XSP5M	GO:0000214	5/83	tRNA-intron endonuclease complex	cellular_component	"A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9]
EOG8XSP5M	GO:0000379	5/83	tRNA-type intron splice site recognition and cleavage	biological_process	"RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8GB9NF	GO:0016818	1/94	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	molecular_function	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]
EOG8GB9NF	GO:0042585	1/94	germinal vesicle	cellular_component	"The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, PMID:19019837]
EOG8GB9NF	GO:0005654	1/94	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG8GB9NF	GO:0007143	1/94	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8GB9NF	GO:0046872	1/94	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GB9NF	GO:0000777	1/94	condensed chromosome kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG8GB9NF	GO:0000776	1/94	kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG8GB9NF	GO:0003677	1/94	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GB9NF	GO:0035042	1/94	fertilization, exchange of chromosomal proteins	biological_process	"Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity." [GOC:bf, PMID:11735001]
EOG8GB9NF	GO:0005634	1/94	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GB9NF	GO:0001940	1/94	male pronucleus	cellular_component	"The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732]
EOG8D294Z	GO:0003682	1/24	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8GB9NH	GO:0005975	5/8	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8GB9NH	GO:0016757	3/8	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8GB9NH	GO:0003945	2/8	N-acetyllactosamine synthase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90]
EOG822CZV	GO:0016021	46/145	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG822CZV	GO:0055085	39/145	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG822CZV	GO:0022857	7/145	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG822CZV	GO:0046331	1/145	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG822CZV	GO:0003676	1/145	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG822CZV	GO:0016298	1/145	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG822CZV	GO:0008270	1/145	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG822CZV	GO:0006629	1/145	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8GB9NN	GO:0008270	31/132	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GB9NN	GO:0006352	31/132	DNA-templated transcription, initiation	biological_process	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]
EOG8GB9NN	GO:0045893	23/132	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8GB9NN	GO:0005634	23/132	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GB9NN	GO:0006355	8/132	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8GB9NN	GO:0003743	2/132	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8GB9NN	GO:0005667	1/132	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8GB9NN	GO:0048812	1/132	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8GB9NN	GO:0008134	1/132	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8GB9NN	GO:0006359	1/132	regulation of transcription from RNA polymerase III promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter." [GOC:go_curators]
EOG8GB9NN	GO:0006383	1/132	transcription from RNA polymerase III promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH]
EOG8SXQSB	GO:0005524	1/30	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SXQSB	GO:0004672	1/30	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG879HP9	GO:0004035	127/508	alkaline phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1]
EOG879HP9	GO:0016791	75/508	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG879HP9	GO:0035094	1/508	response to nicotine	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [CHEBI:17688, GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089]
EOG879HP9	GO:0003824	1/508	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG879HP9	GO:0016021	1/508	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG879HP9	GO:0005576	1/508	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG879HP9	GO:0005615	1/508	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG879HP9	GO:0031225	1/508	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG879HP9	GO:0046872	1/508	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG879HP9	GO:0007399	1/508	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG879HP9	GO:0032504	1/508	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG879HP9	GO:0042045	1/508	epithelial fluid transport	biological_process	"The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830]
EOG879HP9	GO:0005886	1/508	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8WQ3HM	GO:0006979	15/20	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8WQ3HM	GO:0020037	15/20	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8WQ3HM	GO:0004601	15/20	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG8WQ3HM	GO:0004666	2/20	prostaglandin-endoperoxide synthase activity	molecular_function	"Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [EC:1.14.99.1]
EOG8WDGSR	GO:0005622	7/98	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8WDGSR	GO:0005215	7/98	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8WDGSR	GO:0005501	1/98	retinoid binding	molecular_function	"Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732]
EOG8WDGSR	GO:0007602	1/98	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG8WDGSR	GO:0016063	1/98	rhodopsin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
EOG854CFB	GO:0003676	9/34	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG854CFB	GO:0003677	1/34	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG854CFB	GO:0005576	1/34	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG88WFG6	GO:0005524	2/90	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SXQSV	GO:0005351	1/4	sugar:proton symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]
EOG8SXQSV	GO:0009401	1/4	phosphoenolpyruvate-dependent sugar phosphotransferase system	biological_process	"The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html]
EOG8SXQSV	GO:0008982	1/4	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	molecular_function	"Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-]
EOG8SXQSV	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SXQSS	GO:0005887	1/78	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SXQSS	GO:0046331	1/78	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8NP9J8	GO:0046872	23/203	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NP9J8	GO:0008270	11/203	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NP9J8	GO:0003676	6/203	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NP9J8	GO:0015074	1/203	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8NP9J8	GO:0005634	1/203	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NP9J8	GO:0003723	1/203	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8NP9J8	GO:0003964	1/203	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG879HPS	GO:0035556	1/10	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8W9MKP	GO:0007156	1/16	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8W9MKP	GO:0016021	1/16	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W9MKP	GO:0005509	1/16	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG870X14	GO:0016705	4/17	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG870X14	GO:0020037	4/17	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG870X14	GO:0005506	4/17	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8NP9JF	GO:0016787	1/91	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG854CF8	GO:0000287	1/6	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG854CF8	GO:0009165	1/6	nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]
EOG854CF8	GO:0009156	1/6	ribonucleoside monophosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
EOG854CF8	GO:0004749	1/6	ribose phosphate diphosphokinase activity	molecular_function	"Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+)." [EC:2.7.6.1, RHEA:15612]
EOG8V45QH	GO:0000166	25/90	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8V45QH	GO:0003676	24/90	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V45QH	GO:0005634	1/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8V45QH	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8V45QH	GO:0003723	1/90	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8V45QH	GO:0048025	1/90	negative regulation of mRNA splicing, via spliceosome	biological_process	"Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]
EOG8V45QH	GO:0071011	1/90	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8V45QH	GO:0019013	1/90	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8V45QH	GO:0016607	1/90	nuclear speck	cellular_component	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]
EOG8V45QH	GO:0007052	1/90	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8V45QH	GO:0000398	1/90	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8V45QH	GO:0071013	1/90	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8V45QH	GO:0005685	1/90	U1 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U1." [GOC:krc, GOC:mah]
EOG8V45QH	GO:0005681	1/90	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8V45QH	GO:0003729	1/90	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8V45QH	GO:0022008	1/90	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8V45QH	GO:0000381	1/90	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8V45QH	GO:0030529	1/90	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8V45QH	GO:0043484	1/90	regulation of RNA splicing	biological_process	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]
EOG8WQ3H2	GO:0003951	25/110	NAD+ kinase activity	molecular_function	"Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632]
EOG8WQ3H2	GO:0019674	25/110	NAD metabolic process	biological_process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]
EOG8WQ3H2	GO:0006741	25/110	NADP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]
EOG8WQ3H2	GO:0042736	1/110	NADH kinase activity	molecular_function	"Catalysis of the reaction: ATP + NADH = ADP + 2 H(+) + NADPH." [EC:2.7.1.86, RHEA:12263]
EOG88WFGP	GO:0007023	23/78	post-chaperonin tubulin folding pathway	biological_process	"Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors." [PMID:10542094]
EOG88WFGP	GO:0000902	22/78	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG88WFGP	GO:0007010	2/78	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG88WFGP	GO:0022008	1/78	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG879HPG	GO:0003676	12/105	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG879HPG	GO:0022008	1/105	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8NP9JX	GO:0046872	14/78	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89362F	GO:0006096	1/2	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG89362F	GO:0004739	1/2	pyruvate dehydrogenase (acetyl-transferring) activity	molecular_function	"Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1]
EOG89362F	GO:0030976	1/2	thiamine pyrophosphate binding	molecular_function	"Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [CHEBI:45931, GOC:mlg]
EOG8DV827	GO:0009987	1/101	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8WDGV7	GO:0042302	184/825	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8WDGV7	GO:0040003	5/825	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8WDGV7	GO:0031012	5/825	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8WDGV7	GO:0008010	5/825	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8WDGV7	GO:0022008	1/825	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8XSP5J	GO:0003700	15/62	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8XSP5J	GO:0005667	15/62	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8XSP5J	GO:0005634	15/62	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XSP5J	GO:0007179	15/62	transforming growth factor beta receptor signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
EOG8XSP5J	GO:0006351	15/62	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8XSP5J	GO:0006355	6/62	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8XSP5J	GO:0005622	6/62	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8XSP5J	GO:0016335	1/62	morphogenesis of larval imaginal disc epithelium	biological_process	"The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl]
EOG8XSP5J	GO:0035556	1/62	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8XSP5J	GO:0030512	1/62	negative regulation of transforming growth factor beta receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway." [GOC:mah]
EOG8XSP5J	GO:0030617	1/62	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity	molecular_function	"A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators." [PMID:9759503]
EOG8XSP5J	GO:0090254	1/62	cell elongation involved in imaginal disc-derived wing morphogenesis	biological_process	"The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8XSP5J	GO:0061353	1/62	BMP signaling pathway involved in Malpighian tubule cell chemotaxis	biological_process	"A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the directed movement of a Malpighian tubule cell toward a stimulus, thereby contributing to the shaping of the tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG8XSP5J	GO:0005515	1/62	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8XSP5J	GO:0016477	1/62	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG8XSP5J	GO:0048635	1/62	negative regulation of muscle organ development	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development." [GOC:go_curators]
EOG8XSP5J	GO:0045886	1/62	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8XSP5J	GO:0031290	1/62	retinal ganglion cell axon guidance	biological_process	"The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs]
EOG8XSP5J	GO:0035214	1/62	eye-antennal disc development	biological_process	"Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8XSP5J	GO:0007476	1/62	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8XSP5J	GO:0007443	1/62	Malpighian tubule morphogenesis	biological_process	"The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089]
EOG8XSP5J	GO:0042325	1/62	regulation of phosphorylation	biological_process	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]
EOG8XSP5J	GO:0008582	1/62	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8XSP5J	GO:0030718	1/62	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8XSP5J	GO:0007488	1/62	histoblast morphogenesis	biological_process	"The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238]
EOG8XSP5J	GO:0007448	1/62	anterior/posterior pattern specification, imaginal disc	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238]
EOG841SX1	GO:0046872	1/2	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81K1RZ	GO:0007264	8/46	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG81K1RZ	GO:0005099	8/46	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG81K1RZ	GO:0005622	8/46	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8D2943	GO:0016787	1/85	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8D2943	GO:0047617	1/85	acyl-CoA hydrolase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate." [EC:3.1.2.20, MetaCyc:ACYL-COA-HYDROLASE-RXN]
EOG8C5FZR	GO:0016021	59/197	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C5FZR	GO:0022857	55/197	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8C5FZR	GO:0055085	4/197	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8C5FZR	GO:0008643	1/197	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8C5FZN	GO:0004672	1/95	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8C5FZN	GO:0005524	1/95	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KM1GS	GO:0005524	24/131	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KM1GS	GO:0004714	22/131	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8KM1GS	GO:0016021	21/131	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KM1GS	GO:0007169	21/131	transmembrane receptor protein tyrosine kinase signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
EOG8KM1GS	GO:0004713	3/131	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8KM1GS	GO:0005886	2/131	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8KM1GS	GO:0007601	2/131	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8KM1GS	GO:0007465	1/131	R7 cell fate commitment	biological_process	"The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883]
EOG8KM1GS	GO:0005887	1/131	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KM1GS	GO:0045678	1/131	positive regulation of R7 cell differentiation	biological_process	"Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8KM1GS	GO:0005515	1/131	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KM1GS	GO:0045464	1/131	R8 cell fate specification	biological_process	"The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [PMID:11880339]
EOG8KM1GS	GO:0006468	1/131	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8KM1GS	GO:0045466	1/131	R7 cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339]
EOG8KM1GS	GO:0042067	1/131	establishment of ommatidial planar polarity	biological_process	"The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
EOG8KM1GS	GO:0018108	1/131	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG8KM1GS	GO:0008293	1/131	torso signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
EOG8KM1GS	GO:0046534	1/131	positive regulation of photoreceptor cell differentiation	biological_process	"Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
EOG8KM1GS	GO:0008595	1/131	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8KM1GS	GO:0045467	1/131	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8T1M38	GO:0016021	25/54	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C5FZF	GO:0006364	1/103	rRNA processing	biological_process	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
EOG8C5FZF	GO:0005730	1/103	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8C5FZF	GO:0030529	1/103	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8C5FZF	GO:0022008	1/103	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG818F3Q	GO:0008080	33/135	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG818F3Q	GO:0016740	3/135	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG818F3Q	GO:0030431	1/135	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG818F3Q	GO:0048066	1/135	developmental pigmentation	biological_process	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
EOG818F3Q	GO:0004060	1/135	arylamine N-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine." [EC:2.3.1.5]
EOG818F3Q	GO:0045187	1/135	regulation of circadian sleep/wake cycle, sleep	biological_process	"Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981]
EOG818F3Q	GO:0042420	1/135	dopamine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
EOG818F3Q	GO:0006584	1/135	catecholamine metabolic process	biological_process	"The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
EOG818F3Q	GO:0042429	1/135	serotonin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
EOG818F3Q	GO:0046334	1/135	octopamine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732]
EOG818F3Q	GO:0004059	1/135	aralkylamine N-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87]
EOG818F3Q	GO:0030187	1/135	melatonin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732]
EOG818F3Q	GO:0005737	1/135	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8C5FZD	GO:0016491	67/285	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8C5FZD	GO:0004503	7/285	monophenol monooxygenase activity	molecular_function	"Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1, GOC:bf, GOC:sart, PMID:4965136]
EOG8C5FZD	GO:0005576	5/285	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8C5FZD	GO:0046872	4/285	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8C5FZD	GO:0042438	3/285	melanin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [CHEBI:25179, GOC:curators]
EOG8C5FZD	GO:0036264	3/285	dopamine monooxygenase activity	molecular_function	"Catalysis of the reaction: dopamine + O2 = ? + H2O. This reaction catalyzes the oxygenation of dopamine to the corresponding o-quinone." [GOC:sart, PMID:22120533]
EOG8C5FZD	GO:0042417	3/285	dopamine metabolic process	biological_process	"The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
EOG8C5FZD	GO:0036263	3/285	L-DOPA monooxygenase activity	molecular_function	"Catalysis of the reaction: L-DOPA + O2 = ? + H2O. This reaction catalyzes the oxygenation of the dopamine precursor L-DOPA, to the corresponding o-quinone." [GOC:sart, PMID:22120533]
EOG8C5FZD	GO:0004097	2/285	catechol oxidase activity	molecular_function	"Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O." [EC:1.10.3.1]
EOG8C5FZD	GO:0006952	1/285	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8C5FZD	GO:0005615	1/285	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8C5FZD	GO:0006583	1/285	melanin biosynthetic process from tyrosine	biological_process	"The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators]
EOG8N8TJQ	GO:0005524	25/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8N8TJQ	GO:0004674	21/104	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8N8TJQ	GO:0004672	3/104	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8N8TJQ	GO:0007528	1/104	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8N8TJQ	GO:0004683	1/104	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG8N8TJQ	GO:0006487	1/104	protein N-linked glycosylation	biological_process	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]
EOG8N8TJQ	GO:0006468	1/104	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8V9X4K	GO:0008237	137/265	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8V9X4K	GO:0008270	137/265	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V9X4K	GO:0004177	13/265	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG8V9X4K	GO:0006508	2/265	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8V9X4K	GO:0004046	1/265	aminoacylase activity	molecular_function	"Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14]
EOG8V9X4K	GO:0009612	1/265	response to mechanical stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]
EOG8V9X4K	GO:0046331	1/265	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8V9X4K	GO:0006909	1/265	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8V9X4K	GO:0042391	1/265	regulation of membrane potential	biological_process	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
EOG8V9X4K	GO:2001020	1/265	regulation of response to DNA damage stimulus	biological_process	"Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
EOG8V9X4K	GO:0007638	1/265	mechanosensory behavior	biological_process	"Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators]
EOG8THZ93	GO:0003824	6/16	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8THZ93	GO:0004300	3/16	enoyl-CoA hydratase activity	molecular_function	"Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.17]
EOG8V9X4J	GO:0008045	1/100	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8GJ262	GO:0030176	6/41	integral component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
EOG8GJ262	GO:0006886	6/41	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8GJ262	GO:0008430	6/41	selenium binding	molecular_function	"Interacting selectively and non-covalently with selenium (Se)." [GOC:ai]
EOG8X6FR2	GO:0016021	18/94	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X6FR2	GO:0004383	1/94	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG87DCWX	GO:0016787	125/753	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG87DCWX	GO:0003990	29/753	acetylcholinesterase activity	molecular_function	"Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
EOG87DCWX	GO:0052689	10/753	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG87DCWX	GO:0004104	5/753	cholinesterase activity	molecular_function	"Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8]
EOG87DCWX	GO:0005576	3/753	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG87DCWX	GO:0005524	1/753	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87DCWX	GO:0006730	1/753	one-carbon metabolic process	biological_process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
EOG87DCWX	GO:0004013	1/753	adenosylhomocysteinase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1]
EOG87DCWX	GO:0003677	1/753	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG87DCWX	GO:0016021	1/753	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87DCWX	GO:0006260	1/753	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8S7N4Q	GO:0008484	81/332	sulfuric ester hydrolase activity	molecular_function	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]
EOG8S7N4Q	GO:0003943	34/332	N-acetylgalactosamine-4-sulfatase activity	molecular_function	"Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12]
EOG8S7N4Q	GO:0008270	1/332	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8S7N4Q	GO:0042742	1/332	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG87DCWC	GO:0005524	24/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87DCWC	GO:0004674	23/98	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG87DCWC	GO:0004712	10/98	protein serine/threonine/tyrosine kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]
EOG87DCWC	GO:0046777	8/98	protein autophosphorylation	biological_process	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
EOG87DCWC	GO:0008355	1/98	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG87DCWC	GO:0006468	1/98	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG87DCWC	GO:2000253	1/98	positive regulation of feeding behavior	biological_process	"Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol]
EOG87DCWC	GO:0007632	1/98	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG87DCWC	GO:0005634	1/98	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87DCWC	GO:0007399	1/98	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG87DCWC	GO:0030154	1/98	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG87DCWC	GO:0004672	1/98	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG87DCWC	GO:0045927	1/98	positive regulation of growth	biological_process	"Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
EOG87DCWC	GO:0035332	1/98	positive regulation of hippo signaling	biological_process	"Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf]
EOG87DCWC	GO:0007623	1/98	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG87DCWC	GO:0007611	1/98	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG812PM6	GO:0004222	25/103	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG812PM6	GO:0008270	25/103	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG812PM6	GO:0031012	24/103	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG812PM6	GO:0005509	22/103	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG812PM6	GO:0007155	1/103	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG812PM6	GO:0042060	1/103	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG812PM6	GO:0005578	1/103	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG812PM6	GO:0006629	1/103	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG812PM6	GO:0002168	1/103	instar larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG812PM6	GO:0071711	1/103	basement membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah]
EOG812PM6	GO:0030425	1/103	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG812PM6	GO:0035159	1/103	regulation of tube length, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
EOG812PM6	GO:0035001	1/103	dorsal trunk growth, open tracheal system	biological_process	"Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system." [GOC:mtg_sensu, ISBN:0879694238]
EOG812PM6	GO:0030198	1/103	extracellular matrix organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]
EOG812PM6	GO:0007424	1/103	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG812PM6	GO:0034769	1/103	basement membrane disassembly	biological_process	"The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221]
EOG812PM6	GO:0016020	1/103	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG812PM6	GO:0048102	1/103	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG812PM6	GO:0042246	1/103	tissue regeneration	biological_process	"The regrowth of lost or destroyed tissues." [GOC:curators]
EOG812PM6	GO:0007561	1/103	imaginal disc eversion	biological_process	"The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317]
EOG812PM6	GO:0007591	1/103	molting cycle, chitin-based cuticle	biological_process	"The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu]
EOG812PM6	GO:0035071	1/103	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG812PM5	GO:0016021	31/92	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG812PM5	GO:0008324	30/92	cation transmembrane transporter activity	molecular_function	"Enables the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
EOG812PM5	GO:0032440	2/92	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG812PM5	GO:0005622	2/92	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG812PM5	GO:0016324	1/92	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG812PM5	GO:0006882	1/92	cellular zinc ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell." [GOC:ai, GOC:mah]
EOG812PM5	GO:0016323	1/92	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG812PM5	GO:0046873	1/92	metal ion transmembrane transporter activity	molecular_function	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]
EOG812PM5	GO:0030001	1/92	metal ion transport	biological_process	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG812PM5	GO:0010043	1/92	response to zinc ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm]
EOG812PM2	GO:0005634	17/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG812PM2	GO:0005737	17/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG812PM2	GO:0070328	1/95	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG812PM2	GO:0009744	1/95	response to sucrose	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl]
EOG812PM2	GO:0006897	1/95	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG812PM2	GO:0016028	1/95	rhabdomere	cellular_component	"The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774]
EOG812PM2	GO:0016059	1/95	deactivation of rhodopsin mediated signaling	biological_process	"The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831]
EOG812PM2	GO:0042593	1/95	glucose homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]
EOG8V9X96	GO:0008270	1/2	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V9X96	GO:0003964	1/2	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8V9X96	GO:0003723	1/2	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG82JR6B	GO:0005509	23/87	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG82JR6B	GO:0005975	7/87	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG82JR6B	GO:0003824	7/87	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG82JR6B	GO:0050829	1/87	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG82JR6B	GO:0032504	1/87	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG82JR6B	GO:0005794	1/87	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG82JR6B	GO:0005615	1/87	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG812PMC	GO:0005267	5/40	potassium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG812PMC	GO:0016021	5/40	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S7N42	GO:0005524	53/187	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8S7N42	GO:0004674	50/187	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8S7N42	GO:0035556	8/187	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8S7N42	GO:0000287	8/187	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8S7N42	GO:0016021	3/187	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S7N42	GO:0005840	3/187	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8S7N42	GO:0006468	2/187	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8S7N42	GO:0005515	2/187	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8S7N42	GO:0004683	2/187	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG8S7N42	GO:0004672	2/187	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8S7N42	GO:0004711	1/187	ribosomal protein S6 kinase activity	molecular_function	"Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608]
EOG8S7N42	GO:0046533	1/187	negative regulation of photoreceptor cell differentiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
EOG8S7N42	GO:0008340	1/187	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8S7N42	GO:0046777	1/187	protein autophosphorylation	biological_process	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
EOG8S7N42	GO:0008306	1/187	associative learning	biological_process	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
EOG8S7N42	GO:0042308	1/187	negative regulation of protein import into nucleus	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl]
EOG8S7N42	GO:0005700	1/187	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8S7N42	GO:0035106	1/187	operant conditioning	biological_process	"Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior." [PMID:14662373]
EOG8S7N42	GO:0018105	1/187	peptidyl-serine phosphorylation	biological_process	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]
EOG8S7N42	GO:0050941	1/187	negative regulation of pigment cell differentiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai]
EOG8S7N42	GO:0016456	1/187	X chromosome located dosage compensation complex, transcription activating	cellular_component	"An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster." [GOC:ma, GOC:mtg_sensu]
EOG8S7N42	GO:0035175	1/187	histone kinase activity (H3-S10 specific)	molecular_function	"Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3." [GOC:bf, PMID:15041176]
EOG8S7N42	GO:0046580	1/187	negative regulation of Ras protein signal transduction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
EOG8S7N42	GO:0031936	1/187	negative regulation of chromatin silencing	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah]
EOG8S7N42	GO:0005703	1/187	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG8S7N42	GO:0005705	1/187	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG8S7N42	GO:0007275	1/187	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8S7N42	GO:0042683	1/187	negative regulation of compound eye cone cell fate specification	biological_process	"Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell." [GOC:mtg_sensu]
EOG8S7N42	GO:0007528	1/187	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8S7N42	GO:0004697	1/187	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG8S7N42	GO:0045475	1/187	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8S7N42	GO:0007474	1/187	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG8S7N42	GO:0043987	1/187	histone H3-S10 phosphorylation	biological_process	"The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone." [GOC:jl]
EOG8S7N42	GO:0031594	1/187	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8S7N42	GO:0051276	1/187	chromosome organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8S7N42	GO:0048477	1/187	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8S7N42	GO:0016321	1/187	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8S7N42	GO:0003677	1/187	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8S7N42	GO:0006351	1/187	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8S7N42	GO:0016572	1/187	histone phosphorylation	biological_process	"The modification of histones by addition of phosphate groups." [GOC:ai]
EOG8S7N42	GO:0006325	1/187	chromatin organization	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
EOG8S7N42	GO:0000228	1/187	nuclear chromosome	cellular_component	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
EOG8S7N43	GO:0008270	25/133	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8S7N43	GO:0006351	25/133	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8S7N43	GO:0016817	22/133	hydrolase activity, acting on acid anhydrides	molecular_function	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]
EOG8S7N43	GO:0003676	3/133	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8S7N43	GO:0005634	2/133	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8S7N43	GO:0000381	1/133	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8S7N43	GO:0005515	1/133	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8NKF9Q	GO:0016020	55/747	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NKF9Q	GO:0007157	8/747	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]
EOG8NKF9Q	GO:0005887	3/747	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NKF9Q	GO:0007415	2/747	defasciculation of motor neuron axon	biological_process	"Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh]
EOG8NKF9Q	GO:0007411	2/747	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8NKF9Q	GO:0004252	2/747	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8NKF9Q	GO:0005576	1/747	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8NKF9Q	GO:0005515	1/747	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8NKF9Q	GO:0001746	1/747	Bolwig's organ morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380]
EOG8NKF9Q	GO:0016198	1/747	axon choice point recognition	biological_process	"The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152]
EOG8NKF9Q	GO:0008045	1/747	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8NKF9Q	GO:0016201	1/747	synaptic target inhibition	biological_process	"The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]
EOG8NKF9Q	GO:0031225	1/747	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG8S7N41	GO:0000166	18/85	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8S7N41	GO:0046872	2/85	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8S7N41	GO:0008270	1/85	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CC6JD	GO:0008270	4/52	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CC6JD	GO:0005634	4/52	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CC6JD	GO:0046872	1/52	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CC6JD	GO:0016568	1/52	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG844P35	GO:0072588	26/84	box H/ACA RNP complex	cellular_component	"A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex." [GOC:BHF, GOC:BHF_telomerase, GOC:jbu, GOC:mah, GOC:vw, PMID:17284456, PMID:20227365]
EOG844P35	GO:0001522	26/84	pseudouridine synthesis	biological_process	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]
EOG844P35	GO:0030515	26/84	snoRNA binding	molecular_function	"Interacting selectively and non-covalently with small nucleolar RNA." [GOC:mah]
EOG844P35	GO:0042254	25/84	ribosome biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
EOG844P35	GO:0019013	4/84	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG844P35	GO:0006364	1/84	rRNA processing	biological_process	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
EOG844P35	GO:0005730	1/84	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8ZCWND	GO:0003713	9/57	transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8ZCWND	GO:0006355	9/57	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8ZCWND	GO:0004402	1/57	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG86Q96M	GO:0004114	24/95	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular_function	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]
EOG86Q96M	GO:0000156	13/95	phosphorelay response regulator activity	molecular_function	"Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140]
EOG86Q96M	GO:0004871	8/95	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG86Q96M	GO:0007165	4/95	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG86Q96M	GO:0004115	1/95	3',5'-cyclic-AMP phosphodiesterase activity	molecular_function	"Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate." [GOC:ai]
EOG86Q96M	GO:0007498	1/95	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG86Q96M	GO:0046058	1/95	cAMP metabolic process	biological_process	"The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:go_curators]
EOG86Q96M	GO:0046872	1/95	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG86Q96M	GO:0006355	1/95	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG86Q96N	GO:0008270	2/50	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG86Q96N	GO:0004725	1/50	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8C5FZ6	GO:0005634	27/106	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8C5FZ6	GO:0005096	27/106	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8C5FZ6	GO:0051056	22/106	regulation of small GTPase mediated signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
EOG8C5FZ6	GO:0032320	1/106	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8C5FZ6	GO:0005737	1/106	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8C5FZ7	GO:0016740	12/22	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8C5FZ7	GO:0004319	1/22	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	molecular_function	"Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10]
EOG8C5FZ7	GO:0004317	1/22	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.61]
EOG8C5FZ7	GO:0016295	1/22	myristoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14, MetaCyc:RXN-10727]
EOG8C5FZ7	GO:0003824	1/22	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8C5FZ7	GO:0004320	1/22	oleoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14]
EOG8C5FZ7	GO:0016788	1/22	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG8C5FZ7	GO:0004313	1/22	[acyl-carrier-protein] S-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38]
EOG8C5FZ7	GO:0016296	1/22	palmitoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14, MetaCyc:RXN-9549]
EOG8C5FZ7	GO:0009058	1/22	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG8C5FZ7	GO:0008270	1/22	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8C5FZ7	GO:0016491	1/22	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG818F39	GO:0016021	4/43	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG818F39	GO:0004930	4/43	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG818F39	GO:0007218	1/43	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8XKXMX	GO:0046872	22/110	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XKXMX	GO:0016491	17/110	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8XKXMX	GO:0005739	4/110	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8XKXMX	GO:0047988	4/110	hydroxyacid-oxoacid transhydrogenase activity	molecular_function	"Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate." [EC:1.1.99.24, MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN]
EOG8XKXMX	GO:0015993	4/110	molecular hydrogen transport	biological_process	"The directed movement of molecular hydrogen (H2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
EOG8XKXMX	GO:0050093	1/110	methanol dehydrogenase activity	molecular_function	"Catalysis of the reaction: methanol + NAD(+) = formaldehyde + H(+) + NADH." [EC:1.1.1.244, RHEA:19404]
EOG8FJBQ2	GO:0005524	54/181	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8FJBQ2	GO:0003676	53/181	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FJBQ2	GO:0008026	49/181	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8FJBQ2	GO:0008270	5/181	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FJBQ2	GO:0004386	4/181	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8FJBQ2	GO:0002168	1/181	instar larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8FJBQ2	GO:0007283	1/181	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8FJBQ2	GO:0043186	1/181	P granule	cellular_component	"A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
EOG8FJBQ2	GO:0005811	1/181	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8FJBQ2	GO:0006200	1/181	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8FJBQ2	GO:0005737	1/181	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8FJBQ2	GO:0007286	1/181	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG8FJBQ2	GO:0016246	1/181	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG8FJBQ2	GO:0005875	1/181	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8FJBQ2	GO:0016442	1/181	RISC complex	cellular_component	"A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]
EOG8FJBQ2	GO:0010468	1/181	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8FJBQ2	GO:0000070	1/181	mitotic sister chromatid segregation	biological_process	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
EOG8FJBQ2	GO:0048477	1/181	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8FJBQ2	GO:0004004	1/181	ATP-dependent RNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8FJBQ2	GO:0043025	1/181	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8FJBQ2	GO:0003723	1/181	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8FJBQ1	GO:0017153	25/122	sodium:dicarboxylate symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]
EOG8FJBQ1	GO:0016020	24/122	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8FJBQ1	GO:0015813	1/122	L-glutamate transport	biological_process	"The directed movement of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:dph, GOC:tb]
EOG8FJBQ1	GO:0015734	1/122	taurine transport	biological_process	"The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8FJBQ1	GO:0005369	1/122	taurine:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)." [TC:2.A.22.3.3]
EOG8FJBQ1	GO:0005886	1/122	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8FJBQ1	GO:0015183	1/122	L-aspartate transmembrane transporter activity	molecular_function	"Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
EOG8FJBQ1	GO:0015501	1/122	glutamate:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1]
EOG8FJBQ1	GO:0015810	1/122	aspartate transport	biological_process	"The directed movement of aspartate, the anion of aspartic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
EOG8T1M3R	GO:0004521	39/92	endoribonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8T1M3R	GO:0009303	39/92	rRNA transcription	biological_process	"The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732]
EOG8T1M3R	GO:0016021	1/92	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8T1M3R	GO:0090502	1/92	RNA phosphodiester bond hydrolysis, endonucleolytic	biological_process	"The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
EOG81NX1M	GO:0008270	22/81	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81NX1M	GO:0009056	22/81	catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]
EOG81NX1M	GO:0016788	14/81	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG84J4Z2	GO:0008270	20/123	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84J4Z2	GO:0008237	20/123	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG84J4Z2	GO:0005578	20/123	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG84J4Z2	GO:0008233	4/123	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8ZGRTM	GO:0050839	1/154	cell adhesion molecule binding	molecular_function	"Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai]
EOG8ZGRTM	GO:0031362	1/154	anchored component of external side of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG8ZGRTG	GO:0006511	27/103	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8ZGRTG	GO:0008234	20/103	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8ZGRTG	GO:0016579	11/103	protein deubiquitination	biological_process	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]
EOG8ZGRTG	GO:0004221	11/103	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG8ZGRTG	GO:0035019	11/103	somatic stem cell population maintenance	biological_process	"Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089]
EOG8ZGRTG	GO:0005730	11/103	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8ZGRTG	GO:0030718	11/103	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8ZGRTG	GO:1902459	1/103	positive regulation of stem cell population maintenance	biological_process	"Any process that activates or increases the frequency, rate or extent of stem cell population maintenance." [GOC:hjd, GOC:TermGenie, PMID:22969033]
EOG8ZGRTG	GO:0045824	1/103	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG8ZGRTG	GO:0004843	1/103	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG8ZGRTG	GO:0042981	1/103	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8ZGRTG	GO:0005515	1/103	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8ZGRTG	GO:0005634	1/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZGRTG	GO:0035616	1/103	histone H2B conserved C-terminal lysine deubiquitination	biological_process	"A histone deubiquitination process in which a ubiquitin monomer is removed from a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals." [GOC:bf, GOC:vw, PMID:15657442]
EOG8ZGRTG	GO:0031937	1/103	positive regulation of chromatin silencing	biological_process	"Any process that activates or increases the frequency, rate or extent of chromatin silencing." [GOC:mah]
EOG8VHNQR	GO:0016055	4/42	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG88PQ10	GO:0003677	8/102	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG88PQ10	GO:0003676	2/102	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89CSNX	GO:0006869	21/86	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG89CSNX	GO:0016787	1/86	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG83BQ2W	GO:0005524	24/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG83BQ2W	GO:0006177	24/91	GMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732]
EOG83BQ2W	GO:0016462	24/91	pyrophosphatase activity	molecular_function	"Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, GOC:curators]
EOG83BQ2W	GO:0003922	24/91	GMP synthase (glutamine-hydrolyzing) activity	molecular_function	"Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate." [EC:6.3.5.2]
EOG83BQ2W	GO:0008270	1/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83BQ2W	GO:0035800	1/91	deubiquitinase activator activity	molecular_function	"Increases the activity of deubiquitinase, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences." [GOC:sart, ISBN:0120793709]
EOG83BQ2W	GO:0016578	1/91	histone deubiquitination	biological_process	"The modification of histones by removal of ubiquitin groups." [GOC:ai]
EOG83BQ2W	GO:0043234	1/91	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG83BQ2W	GO:0006529	1/91	asparagine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]
EOG83BQ2W	GO:0003676	1/91	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83BQ2W	GO:2000158	1/91	positive regulation of ubiquitin-specific protease activity	biological_process	"Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity." [GOC:obol]
EOG83BQ2W	GO:0008795	1/91	NAD+ synthase activity	molecular_function	"Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+." [EC:6.3.1.5]
EOG83BQ2W	GO:2000152	1/91	regulation of ubiquitin-specific protease activity	biological_process	"Any process that modulates the frequency, rate or extent of regulation of ubiquitin-specific protease activity (deubiquitinase) activity." [GOC:obol]
EOG83BQ2W	GO:0007411	1/91	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG83BQ2W	GO:0004066	1/91	asparagine synthase (glutamine-hydrolyzing) activity	molecular_function	"Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4]
EOG83BQ2W	GO:0005700	1/91	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG85F05J	GO:0042803	1/93	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG85F05J	GO:0030286	1/93	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG85F05J	GO:0042623	1/93	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG85F05J	GO:0005874	1/93	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG85F05J	GO:0007286	1/93	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG85F05J	GO:0007067	1/93	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG85F05J	GO:0045505	1/93	dynein intermediate chain binding	molecular_function	"Interacting selectively and non-covalently with an intermediate chain of the dynein complex." [GOC:bf]
EOG85F05J	GO:2001019	1/93	positive regulation of retrograde axon cargo transport	biological_process	"Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol]
EOG85F05J	GO:0003774	1/93	motor activity	molecular_function	"Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
EOG85F05J	GO:0006200	1/93	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG85F05J	GO:0007018	1/93	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG85F05J	GO:0008340	1/93	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG85F05J	GO:0005737	1/93	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82RGP3	GO:0031515	28/94	tRNA (m1A) methyltransferase complex	cellular_component	"A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer." [PMID:10779558, PMID:14739239]
EOG82RGP3	GO:0016429	28/94	tRNA (adenine-N1-)-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine." [EC:2.1.1.36]
EOG82RGP3	GO:0046331	1/94	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG89CSNP	GO:0005927	1/92	muscle tendon junction	cellular_component	"A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007]
EOG89CSNP	GO:0048104	1/92	establishment of body hair or bristle planar orientation	biological_process	"Orientation of hairs or sensory bristles that cover the body surface of an adult, such that they all point in a uniform direction along the plane of the epithelium from which they project." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb]
EOG89CSNP	GO:0007476	1/92	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG89CSNP	GO:0016324	1/92	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG82RGP4	GO:0003676	2/32	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82RGP4	GO:0003677	1/32	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8D55C1	GO:0005524	27/90	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8D55C1	GO:0004674	27/90	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8D55C1	GO:0007391	1/90	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8D55C1	GO:0045201	1/90	maintenance of neuroblast polarity	biological_process	"The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]
EOG8D55C1	GO:0007052	1/90	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8D55C1	GO:0005737	1/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8D55C1	GO:0016325	1/90	oocyte microtubule cytoskeleton organization	biological_process	"Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]
EOG8D55C1	GO:0004672	1/90	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8D55C1	GO:0007163	1/90	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8D55C1	GO:0005634	1/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D55C1	GO:0046328	1/90	regulation of JNK cascade	biological_process	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8D55C1	GO:0045451	1/90	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8D55C1	GO:0006468	1/90	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8D55C1	GO:0008340	1/90	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8D55C1	GO:0043065	1/90	positive regulation of apoptotic process	biological_process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8D55C1	GO:0055059	1/90	asymmetric neuroblast division	biological_process	"The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
EOG8D55C1	GO:0030709	1/90	border follicle cell delamination	biological_process	"The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261]
EOG8SR0C4	GO:0046872	59/198	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8SR0C4	GO:0004784	57/198	superoxide dismutase activity	molecular_function	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]
EOG8SR0C4	GO:0005737	11/198	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SR0C4	GO:0006801	4/198	superoxide metabolic process	biological_process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl]
EOG8SR0C4	GO:0055114	4/198	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8SR0C4	GO:0005507	2/198	copper ion binding	molecular_function	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]
EOG8SR0C4	GO:0008270	2/198	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SR0C4	GO:0019430	2/198	removal of superoxide radicals	biological_process	"Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [CHEBI:18421, GOC:jl]
EOG8SR0C4	GO:0006979	2/198	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8SR0C4	GO:0005615	1/198	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8SR0C4	GO:0016209	1/198	antioxidant activity	molecular_function	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
EOG8SR0C4	GO:0005777	1/198	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8SR0C4	GO:0007568	1/198	aging	biological_process	"A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death (GO:0016265) and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators]
EOG8SR0C4	GO:0042803	1/198	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8SR0C4	GO:0008340	1/198	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8SR0C4	GO:0009650	1/198	UV protection	biological_process	"Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml]
EOG8D55C2	GO:0005622	25/109	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8D55C2	GO:0007264	24/109	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8D55C2	GO:0005085	24/109	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8D55C2	GO:0051056	22/109	regulation of small GTPase mediated signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
EOG8D55C2	GO:0005088	1/109	Ras guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8D55C2	GO:0016203	1/109	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8D55C2	GO:0007265	1/109	Ras protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf]
EOG8D55C2	GO:0032317	1/109	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8D55C2	GO:0007525	1/109	somatic muscle development	biological_process	"The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
EOG8D55C2	GO:0032854	1/109	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8D55C2	GO:0045214	1/109	sarcomere organization	biological_process	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
EOG8D55C2	GO:0017034	1/109	Rap guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8SR0C1	GO:0005525	27/168	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8SR0C1	GO:0007264	27/168	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8SR0C1	GO:0015031	24/168	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8SR0C1	GO:0008168	4/168	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8SR0C1	GO:0030798	3/168	trans-aconitate 2-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972]
EOG8SR0C1	GO:0016740	2/168	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8SR0C1	GO:0006184	1/168	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8SR0C1	GO:0006887	1/168	exocytosis	biological_process	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
EOG8SR0C1	GO:0019010	1/168	farnesoic acid O-methyltransferase activity	molecular_function	"Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine." [PMID:12135499]
EOG8SR0C1	GO:0048786	1/168	presynaptic active zone	cellular_component	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
EOG8SR0C1	GO:0045202	1/168	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8SR0C1	GO:0030054	1/168	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8SR0C1	GO:0006718	1/168	juvenile hormone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684]
EOG8SR0C1	GO:0035049	1/168	juvenile hormone acid methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to juvenile hormone acid." [GOC:bf]
EOG8SR0C1	GO:0007186	1/168	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8SR0C1	GO:0008021	1/168	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8SR0C1	GO:0004871	1/168	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8SR0C1	GO:0007269	1/168	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8SR0C1	GO:0005834	1/168	heterotrimeric G-protein complex	cellular_component	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684]
EOG8SR0C1	GO:0048790	1/168	maintenance of presynaptic active zone structure	biological_process	"The process in which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr]
EOG8SR0C1	GO:0004767	1/168	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8SR0C1	GO:0016192	1/168	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8W10SW	GO:0005089	2/15	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8W10SW	GO:0016740	1/15	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG88PQ1Q	GO:0006396	23/91	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG88PQ1Q	GO:0071013	1/91	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG88PQ1Q	GO:0000398	1/91	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG88PQ1Q	GO:0071011	1/91	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8VT8DV	GO:0003964	2/6	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8VT8DV	GO:0003723	2/6	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8SXQSR	GO:0006355	25/100	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8SXQSR	GO:0005634	25/100	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SXQSR	GO:0003682	24/100	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8SXQSR	GO:0016568	22/100	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG8SXQSR	GO:0035041	1/100	sperm chromatin decondensation	biological_process	"Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus." [GOC:bf, PMID:11735001]
EOG8SXQSR	GO:0001673	1/100	male germ cell nucleus	cellular_component	"The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu]
EOG8SXQSR	GO:0006336	1/100	DNA replication-independent nucleosome assembly	biological_process	"The formation of nucleosomes outside the context of DNA replication." [GOC:mah]
EOG8SXQSR	GO:0006338	1/100	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG8SXQSR	GO:0042585	1/100	germinal vesicle	cellular_component	"The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, PMID:19019837]
EOG8SXQSR	GO:0004402	1/100	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8SXQSR	GO:0006351	1/100	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8SXQSR	GO:0035042	1/100	fertilization, exchange of chromosomal proteins	biological_process	"Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity." [GOC:bf, PMID:11735001]
EOG88PQ1C	GO:0035556	22/64	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG88PQ1C	GO:0045454	2/64	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG88PQ1C	GO:0008430	2/64	selenium binding	molecular_function	"Interacting selectively and non-covalently with selenium (Se)." [GOC:ai]
EOG8D55CP	GO:0004721	1/93	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8D55CP	GO:0017020	1/93	myosin phosphatase regulator activity	molecular_function	"Modulation of the activity of the enzyme myosin phosphatase." [EC:3.1.3.16, GOC:ai]
EOG8D55CP	GO:0007476	1/93	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8D55CP	GO:0050790	1/93	regulation of catalytic activity	biological_process	"Any process that modulates the activity of an enzyme." [GOC:ai]
EOG8D55CP	GO:0008157	1/93	protein phosphatase 1 binding	molecular_function	"Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl]
EOG8D55CP	GO:0004622	1/93	lysophospholipase activity	molecular_function	"Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5]
EOG84J4ZX	GO:0046872	52/224	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84J4ZX	GO:0016787	45/224	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG84J4ZX	GO:0004177	13/224	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG84J4ZX	GO:0005829	1/224	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG84J4ZX	GO:0006508	1/224	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG84J4ZX	GO:0022008	1/224	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84J4ZX	GO:0070006	1/224	metalloaminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG84J4ZT	GO:0006909	1/84	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG84J4ZT	GO:0005884	1/84	actin filament	cellular_component	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]
EOG84J4ZT	GO:0005737	1/84	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84J4ZT	GO:0016021	1/84	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84J4ZT	GO:0003779	1/84	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG84J4ZT	GO:0005829	1/84	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG84J4ZT	GO:0030041	1/84	actin filament polymerization	biological_process	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG84J4ZT	GO:0005576	1/84	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG84J4ZT	GO:0046872	1/84	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84J4ZT	GO:0005215	1/84	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG84J4ZS	GO:0031965	2/82	nuclear membrane	cellular_component	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
EOG84J4ZS	GO:0005643	2/82	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG84J4ZS	GO:0015031	2/82	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84J4ZS	GO:0051028	2/82	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84J4ZS	GO:0022008	1/82	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8H74RC	GO:0016021	8/36	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8H74RC	GO:0005524	8/36	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8H74RC	GO:0042626	8/36	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8H74RC	GO:0032440	1/36	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8FTZDB	GO:0005524	24/113	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8FTZDB	GO:0004672	23/113	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8FTZDB	GO:0005089	16/113	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8FTZDB	GO:0045214	1/113	sarcomere organization	biological_process	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
EOG8FTZDB	GO:0031430	1/113	M band	cellular_component	"The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194]
EOG8FTZDB	GO:0016772	1/113	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8FTZDB	GO:0007527	1/113	adult somatic muscle development	biological_process	"The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG805VGT	GO:0031047	1/262	gene silencing by RNA	biological_process	"Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054]
EOG805VGT	GO:0048477	1/262	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG805VGT	GO:0045892	1/262	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG805VGT	GO:0005634	1/262	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FTZDF	GO:0003676	25/108	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FTZDF	GO:0005524	25/108	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8FTZDF	GO:0008026	24/108	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8FTZDF	GO:0006310	24/108	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8FTZDF	GO:0004386	1/108	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8FTZDF	GO:0032508	1/108	DNA duplex unwinding	biological_process	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]
EOG8FTZDF	GO:0005634	1/108	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FTZDF	GO:0003924	1/108	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8FTZDF	GO:0045930	1/108	negative regulation of mitotic cell cycle	biological_process	"Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8FTZDF	GO:0010165	1/108	response to X-ray	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray]
EOG8FTZDF	GO:0045002	1/108	double-strand break repair via single-strand annealing	biological_process	"Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats." [PMID:11606529]
EOG8FTZDF	GO:0017116	1/108	single-stranded DNA-dependent ATP-dependent DNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [EC:3.6.1.3, GOC:jl]
EOG8FTZDF	GO:0005525	1/108	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8FTZDF	GO:0006184	1/108	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8FTZDF	GO:0006974	1/108	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8FTZDD	GO:0000042	20/113	protein targeting to Golgi	biological_process	"The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah]
EOG8FTZDD	GO:0003723	17/113	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8FTZDD	GO:0048193	1/113	Golgi vesicle transport	biological_process	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG8FTZDD	GO:0030306	1/113	ADP-ribosylation factor binding	molecular_function	"Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells." [ISBN:0198506732]
EOG8FTZDD	GO:0000138	1/113	Golgi trans cisterna	cellular_component	"The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194]
EOG8FTZDD	GO:0017137	1/113	Rab GTPase binding	molecular_function	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG8FTZDD	GO:0042803	1/113	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8FTZDD	GO:0032440	1/113	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8V71XC	GO:0004197	26/85	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8V71XC	GO:0042765	19/85	GPI-anchor transamidase complex	cellular_component	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]
EOG8V71XC	GO:0003923	19/85	GPI-anchor transamidase activity	molecular_function	"Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309]
EOG8V71XC	GO:0016255	19/85	attachment of GPI anchor to protein	biological_process	"A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595]
EOG8V71XC	GO:0008270	1/85	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V71XC	GO:0003676	1/85	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8T7BJV	GO:0003676	5/26	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QC3PB	GO:0016787	1/22	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8V71XT	GO:0003755	65/213	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8V71XT	GO:0006457	65/213	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8V71XT	GO:0000166	26/213	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8V71XT	GO:0003723	21/213	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8V71XT	GO:0003676	4/213	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V71XT	GO:0003729	1/213	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8V71XT	GO:0042277	1/213	peptide binding	molecular_function	"Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds." [GOC:jl]
EOG8V71XT	GO:0071013	1/213	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8V71XT	GO:0000398	1/213	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8V71XT	GO:0005829	1/213	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8V71XT	GO:0016853	1/213	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8V71XT	GO:0000413	1/213	protein peptidyl-prolyl isomerization	biological_process	"The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570]
EOG8V71XT	GO:0071011	1/213	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8V71XT	GO:0035071	1/213	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8V71XT	GO:0048102	1/213	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8V71XT	GO:0006909	1/213	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8V71XT	GO:0005515	1/213	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8V71XT	GO:0005875	1/213	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8QC3PX	GO:0030170	1/2	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8QC3PX	GO:0003824	1/2	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG85XBBN	GO:0007264	3/83	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG85XBBN	GO:0005525	3/83	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG85XBBN	GO:0005622	2/83	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8V19FP	GO:0016021	24/98	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V19FP	GO:0005216	23/98	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8V19FP	GO:0070588	1/98	calcium ion transmembrane transport	biological_process	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8V19FP	GO:0001964	1/98	startle response	biological_process	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
EOG8V19FP	GO:0048148	1/98	behavioral response to cocaine	biological_process	"Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid]
EOG8V19FP	GO:0040040	1/98	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG8V19FP	GO:0007605	1/98	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8V19FP	GO:0010996	1/98	response to auditory stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus." [GOC:BHF, GOC:dph, GOC:sl, GOC:tb]
EOG8V19FP	GO:0043052	1/98	thermotaxis	biological_process	"The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
EOG8V19FP	GO:0007608	1/98	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8V19FP	GO:0007629	1/98	flight behavior	biological_process	"The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
EOG8V19FP	GO:0009408	1/98	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8V19FP	GO:0048060	1/98	negative gravitaxis	biological_process	"The directed movement of a motile cell or organism away from the source of gravity." [GOC:jid]
EOG8V19FP	GO:0006816	1/98	calcium ion transport	biological_process	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8V19FP	GO:0005262	1/98	calcium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8V19FS	GO:0016787	15/283	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8V19FS	GO:0050357	6/283	tropinesterase activity	molecular_function	"Catalysis of the reaction: atropine + H(2)O = H(+) + tropate + tropine." [EC:3.1.1.10, RHEA:23307]
EOG8V19FS	GO:0007275	1/283	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8V19FS	GO:0003676	1/283	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V19FS	GO:0017171	1/283	serine hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [Wikipedia:Serine_hydrolase]
EOG8V19FS	GO:0000166	1/283	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8V19FS	GO:0007586	1/283	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG8V19FS	GO:0008152	1/283	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8V19FS	GO:0009636	1/283	response to toxic substance	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr]
EOG8V19FW	GO:0016021	24/84	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V19FW	GO:0004930	24/84	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8V19FW	GO:0005887	1/84	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V19FW	GO:0007216	1/84	G-protein coupled glutamate receptor signaling pathway	biological_process	"A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252]
EOG8V19FW	GO:0008066	1/84	glutamate receptor activity	molecular_function	"Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]
EOG8V19FW	GO:0051966	1/84	regulation of synaptic transmission, glutamatergic	biological_process	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
EOG8V45QS	GO:0007219	2/34	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8V45QS	GO:0016021	2/34	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V45QS	GO:0007275	2/34	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG84J527	GO:0003676	1/17	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V19F8	GO:0005634	12/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZKN28	GO:0008168	24/162	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8ZKN28	GO:0030798	11/162	trans-aconitate 2-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972]
EOG8V19F5	GO:0016021	70/163	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V19F5	GO:0055085	1/163	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8V19F5	GO:0048812	1/163	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8RZ1GB	GO:0008137	2/87	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8RZ1GB	GO:0003954	1/87	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8KPWR3	GO:0016021	25/110	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KPWR3	GO:0004252	24/110	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8KPWR3	GO:0005783	1/110	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8KPWR3	GO:0015031	1/110	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8KPWR3	GO:0008270	1/110	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KPWR3	GO:0010841	1/110	positive regulation of circadian sleep/wake cycle, wakefulness	biological_process	"Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:BHF, GOC:dph, GOC:tb]
EOG8KPWR3	GO:0003676	1/110	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KPWR3	GO:0030431	1/110	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8KPWR3	GO:0042059	1/110	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8KPWR3	GO:0005789	1/110	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8KPWR3	GO:0006508	1/110	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8KPWR3	GO:0042058	1/110	regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG80GG68	GO:0008080	5/55	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG8DJN9B	GO:0005525	27/99	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8DJN9B	GO:0005730	22/99	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8DJN9B	GO:0042254	22/99	ribosome biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
EOG805VG7	GO:0005506	679/2000	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG805VG7	GO:0020037	679/2000	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG805VG7	GO:0016705	629/2000	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG805VG7	GO:0004497	607/2000	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG805VG7	GO:0070330	31/2000	aromatase activity	molecular_function	"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
EOG805VG7	GO:0005789	25/2000	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG805VG7	GO:0050591	15/2000	quinine 3-monooxygenase activity	molecular_function	"Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152]
EOG805VG7	GO:0004796	4/2000	thromboxane-A synthase activity	molecular_function	"Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17140]
EOG805VG7	GO:0031000	2/2000	response to caffeine	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah]
EOG805VG7	GO:0009055	2/2000	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG805VG7	GO:0016712	2/2000	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
EOG805VG7	GO:0017085	2/2000	response to insecticide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]
EOG805VG7	GO:0006697	1/2000	ecdysone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732]
EOG805VG7	GO:0050829	1/2000	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG805VG7	GO:0030178	1/2000	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG805VG7	GO:0017143	1/2000	insecticide metabolic process	biological_process	"The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai]
EOG805VG7	GO:0046701	1/2000	insecticide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai]
EOG805VG7	GO:0022416	1/2000	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG805VG7	GO:0042742	1/2000	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG805VG7	GO:0048252	1/2000	lauric acid metabolic process	biological_process	"The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [CHEBI:30805, GOC:jid]
EOG805VG7	GO:0016020	1/2000	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG805VG7	GO:1901563	1/2000	response to camptothecin	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie]
EOG805VG7	GO:0018685	1/2000	alkane 1-monooxygenase activity	molecular_function	"Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3]
EOG805VG7	GO:0033777	1/2000	lithocholate 6beta-hydroxylase activity	molecular_function	"Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.13.94, RHEA:18860]
EOG805VG7	GO:0002118	1/2000	aggressive behavior	biological_process	"A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd]
EOG805VG7	GO:0046683	1/2000	response to organophosphorus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544]
EOG805VG7	GO:0035220	1/2000	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG805VG7	GO:0048638	1/2000	regulation of developmental growth	biological_process	"Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators]
EOG805VG7	GO:0040040	1/2000	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG805VG7	GO:0046680	1/2000	response to DDT	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544]
EOG805VG7	GO:0046689	1/2000	response to mercury ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai]
EOG8T7BJ6	GO:0006457	9/35	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG86T5FP	GO:0005272	12/78	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG86T5FP	GO:0016021	8/78	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86T5FP	GO:0016020	4/78	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8V71X6	GO:0017183	26/90	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	biological_process	"The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380, RESID:AA0040]
EOG8V71X6	GO:0005737	26/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Z0DP5	GO:0019013	4/87	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8Z0DP5	GO:0030529	4/87	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8Z0DP5	GO:0007067	1/87	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8Z0DP5	GO:0007422	1/87	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8Z0DP5	GO:0007517	1/87	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8Z0DP5	GO:0071011	1/87	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8Z0DP5	GO:0045451	1/87	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8Z0DP5	GO:0048542	1/87	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG8Z0DP5	GO:0005681	1/87	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8Z0DP5	GO:0045495	1/87	pole plasm	cellular_component	"Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380]
EOG8Z0DP5	GO:0030182	1/87	neuron differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
EOG8Z0DP5	GO:0030532	1/87	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8Z0DP5	GO:0007417	1/87	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8Z0DP5	GO:0007052	1/87	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8Z0DP5	GO:0071013	1/87	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8Z0DP5	GO:0000398	1/87	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8FTZFW	GO:0003700	23/88	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8FTZFW	GO:0043565	23/88	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8FTZFW	GO:0005634	4/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FTZFW	GO:0042981	1/88	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8FTZFW	GO:0042803	1/88	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8FTZFW	GO:0035293	1/88	chitin-based larval cuticle pattern formation	biological_process	"The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8FTZFW	GO:0009953	1/88	dorsal/ventral pattern formation	biological_process	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8FTZFW	GO:0003677	1/88	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FTZFW	GO:0045893	1/88	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8FTZFW	GO:0006351	1/88	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8FTZFW	GO:0001158	1/88	enhancer sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH]
EOG8FTZFW	GO:0005700	1/88	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8FTZFW	GO:0007435	1/88	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8FTZFW	GO:0007431	1/88	salivary gland development	biological_process	"The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044]
EOG8FTZFW	GO:0008363	1/88	larval chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG8FTZFW	GO:0045944	1/88	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG86T5FB	GO:0005977	28/109	glycogen metabolic process	biological_process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]
EOG86T5FB	GO:0004553	27/109	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG86T5FB	GO:0016301	5/109	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG86T5FB	GO:0005886	1/109	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8NP9KB	GO:0003677	23/95	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NP9KB	GO:0005666	22/95	DNA-directed RNA polymerase III complex	cellular_component	"RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8NP9KB	GO:0006383	22/95	transcription from RNA polymerase III promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH]
EOG8NP9KB	GO:0003899	22/95	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8NP9KB	GO:0005524	1/95	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8J6V5C	GO:0006799	1/7	polyphosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid." [ISBN:0198506732]
EOG8J6V5C	GO:0009358	1/7	polyphosphate kinase complex	cellular_component	"A protein complex that possesses polyphosphate kinase activity." [GOC:mah]
EOG8J6V5C	GO:0008976	1/7	polyphosphate kinase activity	molecular_function	"Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)." [EC:2.7.4.1]
EOG8J6V5N	GO:0016747	1/8	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8J6V5R	GO:0003676	8/63	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8J6V5R	GO:0015074	7/63	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8J6V5R	GO:0005634	2/63	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WHC2F	GO:0016021	5/15	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C8B6S	GO:0016021	1/60	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J6V5X	GO:0005351	26/88	sugar:proton symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]
EOG8J6V5X	GO:0016021	26/88	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J6V5X	GO:0000139	26/88	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8J6V5X	GO:0015780	24/88	nucleotide-sugar transport	biological_process	"The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]
EOG8J6V5X	GO:0005338	24/88	nucleotide-sugar transmembrane transporter activity	molecular_function	"Enables the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926]
EOG8J6V5X	GO:0005797	1/88	Golgi medial cisterna	cellular_component	"The middle Golgi cisterna (or cisternae)." [ISBN:0815316194]
EOG8J6V5X	GO:0072334	1/88	UDP-galactose transmembrane transport	biological_process	"The directed movement of UDP-galactose across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8J6V5X	GO:0005463	1/88	UDP-N-acetylgalactosamine transmembrane transporter activity	molecular_function	"Catalysis of the transfer of a N-acetylgalactosamine from one side of the membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8J6V5X	GO:0015757	1/88	galactose transport	biological_process	"The directed movement of galactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai]
EOG8J6V5X	GO:0015789	1/88	UDP-N-acetylgalactosamine transport	biological_process	"The directed movement of UDP-N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
EOG8J6V5X	GO:0005459	1/88	UDP-galactose transmembrane transporter activity	molecular_function	"Catalysis of the transfer of a UDP-galactose from one side of the membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8J6V5X	GO:0015785	1/88	UDP-galactose transport	biological_process	"The directed movement of UDP-galactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai]
EOG8B5RKV	GO:0005524	25/87	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8B5RKV	GO:0004674	23/87	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8B5RKV	GO:0004683	2/87	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG8B5RKV	GO:0007155	1/87	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8B5RKV	GO:0004672	1/87	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8B5RKV	GO:0009651	1/87	response to salt stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]
EOG8B5RKV	GO:0046328	1/87	regulation of JNK cascade	biological_process	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8B5RKV	GO:0006468	1/87	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8B5RKV	GO:0008360	1/87	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8B5RKV	GO:0045793	1/87	positive regulation of cell size	biological_process	"Any process that increases cell size." [GOC:go_curators]
EOG8DBWV6	GO:0005576	6/108	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8DBWV6	GO:0040007	2/108	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG8DBWV6	GO:0005200	1/108	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8DBWV6	GO:0007010	1/108	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8DBWV6	GO:0005884	1/108	actin filament	cellular_component	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]
EOG8DBWV6	GO:0005869	1/108	dynactin complex	cellular_component	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]
EOG8B5RKS	GO:0004185	64/157	serine-type carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8JWXVJ	GO:0005525	1/46	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8JWXVJ	GO:0003924	1/46	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8P8J10	GO:0016021	6/12	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8P8J10	GO:0004930	4/12	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8P8J10	GO:0004983	2/12	neuropeptide Y receptor activity	molecular_function	"Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
EOG81K1SC	GO:0005089	22/71	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG81K1SC	GO:0035556	4/71	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG81K1SC	GO:0008360	1/71	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG81K1SC	GO:0035025	1/71	positive regulation of Rho protein signal transduction	biological_process	"Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]
EOG81K1SC	GO:0005634	1/71	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81K1SC	GO:0032319	1/71	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG81K1SC	GO:0051496	1/71	positive regulation of stress fiber assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]
EOG81K1SC	GO:0005737	1/71	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CG2P1	GO:0003682	27/106	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8CG2P1	GO:0005700	1/106	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8CG2P1	GO:0007305	1/106	vitelline membrane formation involved in chorion-containing eggshell formation	biological_process	"Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8CG2P1	GO:0016740	1/106	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8CG2P1	GO:0007306	1/106	eggshell chorion assembly	biological_process	"Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8CG2P1	GO:0031936	1/106	negative regulation of chromatin silencing	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah]
EOG8CG2P1	GO:0007480	1/106	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8CG2P1	GO:0032440	1/106	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8R267X	GO:0004842	23/92	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8R267X	GO:0008270	21/92	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8R267X	GO:0046872	2/92	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8R267X	GO:0045747	1/92	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8R267X	GO:0046331	1/92	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8R267X	GO:0008593	1/92	regulation of Notch signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8R267X	GO:0005829	1/92	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8R267X	GO:0007423	1/92	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8R267X	GO:0005515	1/92	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8R267X	GO:0007219	1/92	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8R267X	GO:0016567	1/92	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8R267X	GO:0005737	1/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8R267X	GO:0045179	1/92	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8R267X	GO:0008104	1/92	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8R267X	GO:0006897	1/92	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8B5RKG	GO:0000166	21/77	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8B5RKG	GO:0003723	20/77	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8B5RKG	GO:0046872	20/77	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8B5RKG	GO:0005634	20/77	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8B5RKG	GO:0003729	1/77	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8B5RKG	GO:0005681	1/77	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8B5RKG	GO:0042060	1/77	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8B5RKG	GO:0000398	1/77	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8MPM42	GO:0045944	1/82	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8MPM42	GO:0007099	1/82	centriole replication	biological_process	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194]
EOG8MPM42	GO:0044545	1/82	NSL complex	cellular_component	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852]
EOG8MPM42	GO:0022008	1/82	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8MPM42	GO:0007095	1/82	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8MPM42	GO:0005634	1/82	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8JMB79	GO:0009058	1/3	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG8JMB79	GO:0016491	1/3	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8R52JX	GO:0016021	4/12	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81K1SR	GO:0008270	44/198	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81K1SR	GO:0043154	1/198	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG81K1SR	GO:0007423	1/198	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG81K1SR	GO:0004842	1/198	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG81K1SR	GO:0003677	1/198	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81K1SR	GO:0007289	1/198	spermatid nucleus differentiation	biological_process	"The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah]
EOG81K1SR	GO:0007283	1/198	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG81K1SR	GO:0019788	1/198	NEDD8 transferase activity	molecular_function	"Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages." [GOC:mah]
EOG81K1SR	GO:0005737	1/198	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG81K1SR	GO:0007298	1/198	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG81K1SR	GO:0051865	1/198	protein autoubiquitination	biological_process	"The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]
EOG81K1SR	GO:0006352	1/198	DNA-templated transcription, initiation	biological_process	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]
EOG81K1SR	GO:0008407	1/198	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG81K1SR	GO:0009987	1/198	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG81K1SR	GO:0007275	1/198	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG81K1SR	GO:0008354	1/198	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG81K1SR	GO:0045035	1/198	sensory organ precursor cell division	biological_process	"The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597]
EOG81K1SR	GO:0048800	1/198	antennal morphogenesis	biological_process	"The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid]
EOG81K1SR	GO:1990001	1/198	inhibition of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process." [GOC:mtg_apoptosis, PMID:11943137]
EOG81K1SR	GO:0005634	1/198	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81K1SR	GO:0005515	1/198	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG81K1SR	GO:0046673	1/198	negative regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG81K1SR	GO:0031398	1/198	positive regulation of protein ubiquitination	biological_process	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]
EOG81K1SR	GO:0016055	1/198	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG81K1SR	GO:0097340	1/198	inhibition of cysteine-type endopeptidase activity	biological_process	"Any process that prevents the activation of an inactive cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:20383739]
EOG81K1SR	GO:0019899	1/198	enzyme binding	molecular_function	"Interacting selectively and non-covalently with any enzyme." [GOC:jl]
EOG81K1SR	GO:0090263	1/198	positive regulation of canonical Wnt signaling pathway	biological_process	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]
EOG81K1SR	GO:0043066	1/198	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG81K1SR	GO:0042787	1/198	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological_process	"The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]
EOG81K1SR	GO:0006915	1/198	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG81K1SR	GO:0004869	1/198	cysteine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb]
EOG8MPM44	GO:0005938	1/87	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8MPM44	GO:0005515	1/87	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8MPM44	GO:0045921	1/87	positive regulation of exocytosis	biological_process	"Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators]
EOG8MPM44	GO:0043234	1/87	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8MPM44	GO:0045177	1/87	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8MPM44	GO:0005737	1/87	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8MPM44	GO:0008017	1/87	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG84TRTW	GO:0003723	2/11	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG84TRTW	GO:0003964	2/11	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8MPM4J	GO:0006355	27/91	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8MPM4J	GO:0000079	27/91	regulation of cyclin-dependent protein serine/threonine kinase activity	biological_process	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]
EOG8MPM4J	GO:0006396	24/91	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8MPM4J	GO:0005634	23/91	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8MPM4J	GO:0022008	1/91	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8Z0DKG	GO:0000139	2/123	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8Z0DKG	GO:0009967	2/123	positive regulation of signal transduction	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]
EOG8Z0DKG	GO:0019901	2/123	protein kinase binding	molecular_function	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]
EOG8Z0DKG	GO:0005078	2/123	MAP-kinase scaffold activity	molecular_function	"The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently." [PMID:12511654, PMID:15213240, PMID:9405336]
EOG8Z0DKG	GO:0008088	2/123	axon cargo transport	biological_process	"The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194]
EOG8Z0DKG	GO:0046328	2/123	regulation of JNK cascade	biological_process	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8Z0DKG	GO:0016192	2/123	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8Z0DKG	GO:0019894	2/123	kinesin binding	molecular_function	"Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]
EOG8Z0DKG	GO:0030140	2/123	trans-Golgi network transport vesicle	cellular_component	"A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah]
EOG8Z0DKG	GO:0016301	1/123	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8DBWVS	GO:0052726	11/51	inositol-1,3,4-trisphosphate 5-kinase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.134]
EOG8DBWVS	GO:0047325	11/51	inositol tetrakisphosphate 1-kinase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.134, MetaCyc:2.7.1.134-RXN]
EOG8DBWVS	GO:0032957	11/51	inositol trisphosphate metabolic process	biological_process	"The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [CHEBI:24540, CHEBI:24848, GOC:mah]
EOG8DBWVS	GO:0052725	11/51	inositol-1,3,4-trisphosphate 6-kinase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.134]
EOG8DBWVS	GO:0000287	11/51	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8DBWVS	GO:0005524	11/51	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8DBWVS	GO:0005622	11/51	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8DBWVR	GO:0004850	58/135	uridine phosphorylase activity	molecular_function	"Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3]
EOG8DBWVR	GO:0005737	56/135	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8DBWVR	GO:0009166	56/135	nucleotide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]
EOG8DBWVR	GO:0009116	44/135	nucleoside metabolic process	biological_process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]
EOG8DBWVR	GO:0044206	15/135	UMP salvage	biological_process	"Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis." [GOC:ecd, PMID:15096496]
EOG8DBWVR	GO:0016763	1/135	transferase activity, transferring pentosyl groups	molecular_function	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8DBWVR	GO:0000123	1/135	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG8DBWVR	GO:0042332	1/135	gravitaxis	biological_process	"The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
EOG8NZXB9	GO:0000151	1/69	ubiquitin ligase complex	cellular_component	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
EOG8NZXB9	GO:0004842	1/69	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8R52J2	GO:0007606	1/87	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8R52J2	GO:0005515	1/87	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8R52J2	GO:0003824	1/87	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG81K1S7	GO:0003834	3/101	beta-carotene 15,15'-monooxygenase activity	molecular_function	"Catalysis of the reaction: beta-carotene + O(2) = 2 retinal." [EC:1.14.99.36, RHEA:10407]
EOG81K1S7	GO:0004497	2/101	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG81K1S7	GO:0007602	1/101	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG81K1S7	GO:0009110	1/101	vitamin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:go_curators, ISBN:0198506732]
EOG81K1S7	GO:0046872	1/101	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81K1S7	GO:0010436	1/101	carotenoid dioxygenase activity	molecular_function	"Catalysis of the oxidative cleavage of carotenoids." [PMID:16459333]
EOG81K1S7	GO:0016119	1/101	carotene metabolic process	biological_process	"The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids." [ISBN:0198547684]
EOG81K1S7	GO:0004744	1/101	retinal isomerase activity	molecular_function	"Catalysis of the reaction: all-trans-retinal = 11-cis-retinal." [RHEA:24127]
EOG81K1S7	GO:0035238	1/101	vitamin A biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals cannot synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids." [PMID:11158606]
EOG81K1S7	GO:0042574	1/101	retinal metabolic process	biological_process	"The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [CHEBI:15035, GOC:curators, ISBN:0198506732]
EOG81K1S7	GO:0016063	1/101	rhodopsin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
EOG81K1S7	GO:0042572	1/101	retinol metabolic process	biological_process	"The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]
EOG8284JH	GO:0004715	1/31	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8909RZ	GO:0003735	27/107	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8909RZ	GO:0005840	27/107	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8909RZ	GO:0006412	27/107	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8909RZ	GO:0000022	2/107	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8909RZ	GO:0007052	2/107	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG83BQ4M	GO:0005085	6/45	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG83BQ4M	GO:0007264	6/45	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8BP3RP	GO:0007165	8/65	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8BP3RP	GO:0005622	8/65	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8KWN9W	GO:0004523	1/13	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8KWN9W	GO:0003676	1/13	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8J6V54	GO:0016787	37/138	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8J6V54	GO:0052689	2/138	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG8J6V54	GO:0003990	1/138	acetylcholinesterase activity	molecular_function	"Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
EOG8PP0ZX	GO:0005739	1/84	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8PP0ZX	GO:0005515	1/84	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG87H83V	GO:0005886	1/19	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG87H83V	GO:0005509	1/19	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG87H83V	GO:0016021	1/19	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87H83V	GO:0007156	1/19	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8C8B65	GO:0080019	1/117	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG87H83Z	GO:0042147	24/97	retrograde transport, endosome to Golgi	biological_process	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]
EOG87H83Z	GO:0007286	1/97	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG87H83Z	GO:0015031	1/97	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG87H83Z	GO:0007291	1/97	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG87H83Z	GO:0006896	1/97	Golgi to vacuole transport	biological_process	"The directed movement of substances from the Golgi to the vacuole." [GOC:ai]
EOG87H83Z	GO:0005794	1/97	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG87H83Z	GO:0005739	1/97	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8CRPCZ	GO:0005097	26/91	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8TTJXW	GO:0042578	30/105	phosphoric ester hydrolase activity	molecular_function	"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]
EOG8NZX96	GO:0009103	15/95	lipopolysaccharide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai, GOC:mr]
EOG8NZX96	GO:0016757	4/95	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8NZX96	GO:0005788	4/95	endoplasmic reticulum lumen	cellular_component	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]
EOG8NZX96	GO:0008475	1/95	procollagen-lysine 5-dioxygenase activity	molecular_function	"Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4]
EOG8NZX96	GO:0005581	1/95	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG80CKZQ	GO:0005524	47/193	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG80CKZQ	GO:0004674	43/193	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG80CKZQ	GO:0004712	5/193	protein serine/threonine/tyrosine kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]
EOG80CKZQ	GO:0004672	5/193	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG80CKZQ	GO:0004713	2/193	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG80CKZQ	GO:0007608	1/193	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG80CKZQ	GO:0009416	1/193	response to light stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
EOG80CKZQ	GO:0042048	1/193	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG80CKZQ	GO:0005829	1/193	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG80CKZQ	GO:0006468	1/193	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG80CKZQ	GO:0016740	1/193	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG80CKZQ	GO:0016772	1/193	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8935Z5	GO:0006260	19/59	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8935Z5	GO:0033557	19/59	Slx1-Slx4 complex	cellular_component	"A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377]
EOG8935Z5	GO:0006281	19/59	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8935Z5	GO:0017108	19/59	5'-flap endonuclease activity	molecular_function	"Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254]
EOG8935Z5	GO:0007131	1/59	reciprocal meiotic recombination	biological_process	"The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]
EOG8935Z5	GO:0043234	1/59	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8935Z5	GO:0000712	1/59	resolution of meiotic recombination intermediates	biological_process	"The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]
EOG8935Z5	GO:0045132	1/59	meiotic chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah]
EOG8935Z5	GO:0008283	1/59	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8935Z5	GO:0005515	1/59	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8935Z5	GO:0007095	1/59	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8VT8C7	GO:0016021	2/95	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80CKZM	GO:0009107	23/135	lipoate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732]
EOG80CKZM	GO:0016415	23/135	octanoyltransferase activity	molecular_function	"Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule." [GOC:ai]
EOG80CKZM	GO:0005739	22/135	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG80CKZM	GO:0033819	22/135	lipoyl(octanoyl) transferase activity	molecular_function	"Catalysis of the reaction: octanoyl-[acyl-carrier protein] + protein = protein N6-(octanoyl)lysine + acyl-carrier protein." [EC:2.3.1.181]
EOG80CKZM	GO:0006464	22/135	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG80CKZM	GO:0008408	18/135	3'-5' exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]
EOG80CKZM	GO:0003676	18/135	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80CKZM	GO:0005634	12/135	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80CKZM	GO:0045950	12/135	negative regulation of mitotic recombination	biological_process	"Any process that inhibits or decreases the rate of DNA recombination during mitosis." [GOC:go_curators, GOC:hjd]
EOG80CKZM	GO:0046872	12/135	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80CKZM	GO:0090305	11/135	nucleic acid phosphodiester bond hydrolysis	biological_process	"The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
EOG80CKZM	GO:0016874	5/135	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG80CKZM	GO:0009249	1/135	protein lipoylation	biological_process	"The addition of a lipoyl group to an amino acid residue in a protein." [GOC:mah]
EOG80CKZM	GO:0000738	1/135	DNA catabolic process, exonucleolytic	biological_process	"The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
EOG80CKZM	GO:0005737	1/135	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG80CKZM	GO:0008310	1/135	single-stranded DNA 3'-5' exodeoxyribonuclease activity	molecular_function	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358]
EOG80CKZM	GO:0008311	1/135	double-stranded DNA 3'-5' exodeoxyribonuclease activity	molecular_function	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah, PMID:22562358]
EOG8VT8C8	GO:0003677	2/79	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8VT8C8	GO:0032133	2/79	chromosome passenger complex	cellular_component	"A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910]
EOG8VT8C8	GO:0008104	1/79	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8VT8C8	GO:0007052	1/79	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8VT8C8	GO:0016572	1/79	histone phosphorylation	biological_process	"The modification of histones by addition of phosphate groups." [GOC:ai]
EOG8VT8C8	GO:0045448	1/79	mitotic cell cycle, embryonic	biological_process	"The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators]
EOG8VT8C8	GO:0000775	1/79	chromosome, centromeric region	cellular_component	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
EOG8VT8C8	GO:0007060	1/79	male meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai]
EOG8VT8C8	GO:0051233	1/79	spindle midzone	cellular_component	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
EOG8VT8C8	GO:0005515	1/79	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VT8C8	GO:0000281	1/79	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8VT8C8	GO:0005634	1/79	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VT8C8	GO:0000785	1/79	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG8VT8C8	GO:0007067	1/79	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8VT8C8	GO:0007112	1/79	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG8VT8C8	GO:0007065	1/79	male meiosis sister chromatid cohesion	biological_process	"The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male." [GOC:ai]
EOG8VT8C8	GO:0005938	1/79	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8H1D8T	GO:0005524	1/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8H1D8T	GO:0004713	1/104	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8H1D8T	GO:0042384	1/104	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8T1M2J	GO:0016788	2/29	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG8T1M2J	GO:0003676	2/29	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8T1M2J	GO:0010529	1/29	negative regulation of transposition	biological_process	"Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]
EOG8T1M2J	GO:0043186	1/29	P granule	cellular_component	"A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
EOG8T1M2J	GO:0030717	1/29	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG88D396	GO:0032440	2/117	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG88D396	GO:0008544	1/117	epidermis development	biological_process	"The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]
EOG88D396	GO:0035317	1/117	imaginal disc-derived wing hair organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853]
EOG88D396	GO:0048477	1/117	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG88D396	GO:0045177	1/117	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG88D396	GO:0030725	1/117	germline ring canal formation	biological_process	"Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts." [ISBN:0879694238]
EOG88D396	GO:0016311	1/117	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG88D396	GO:0007560	1/117	imaginal disc morphogenesis	biological_process	"The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid]
EOG88D396	GO:0017018	1/117	myosin phosphatase activity	molecular_function	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]
EOG88D396	GO:0048675	1/117	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG88D396	GO:0007391	1/117	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG88D396	GO:0045314	1/117	regulation of compound eye photoreceptor development	biological_process	"Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
EOG88D396	GO:0045179	1/117	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG80306F	GO:0005509	24/91	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG80306F	GO:0006898	22/91	receptor-mediated endocytosis	biological_process	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
EOG80306F	GO:0005515	1/91	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG81VNJN	GO:0008270	3/26	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8T1M2X	GO:0003700	22/68	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8T1M2X	GO:0043565	22/68	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8T1M2X	GO:0042803	1/68	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG80306S	GO:0008270	1/116	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80306T	GO:0005234	10/49	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG80306T	GO:0016020	10/49	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG80306T	GO:0004970	10/49	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8D2951	GO:0003677	20/68	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8D2951	GO:0003682	19/68	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8D2951	GO:0008270	6/68	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D2951	GO:0016573	1/68	histone acetylation	biological_process	"The modification of a histone by the addition of an acetyl group." [GOC:ai]
EOG8D2951	GO:0043967	1/68	histone H4 acetylation	biological_process	"The modification of histone H4 by the addition of an acetyl group." [GOC:jl]
EOG8D2951	GO:0000123	1/68	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG8D2951	GO:0006338	1/68	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG8D2951	GO:0004402	1/68	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8D2951	GO:0043966	1/68	histone H3 acetylation	biological_process	"The modification of histone H3 by the addition of an acetyl group." [GOC:jl]
EOG8DV81S	GO:0003676	6/1523	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DV81S	GO:0015074	4/1523	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8DV81S	GO:0003677	3/1523	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DV81S	GO:0008270	2/1523	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DV81S	GO:0003723	2/1523	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8DV81S	GO:0003964	2/1523	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8DV81S	GO:0005524	1/1523	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8DV81S	GO:0008234	1/1523	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8DV81S	GO:0004518	1/1523	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG84TRPD	GO:0003676	1/56	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84TRPD	GO:0008270	1/56	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D295J	GO:0003676	1/33	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8D295H	GO:0004422	3/17	hypoxanthine phosphoribosyltransferase activity	molecular_function	"Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators]
EOG8D295H	GO:0006166	2/17	purine ribonucleoside salvage	biological_process	"Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl]
EOG8D295H	GO:0005737	2/17	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8D295H	GO:0016491	1/17	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8D295H	GO:0005507	1/17	copper ion binding	molecular_function	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]
EOG8D295H	GO:0009116	1/17	nucleoside metabolic process	biological_process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]
EOG8D295H	GO:0016740	1/17	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8D295H	GO:0052657	1/17	guanine phosphoribosyltransferase activity	molecular_function	"Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators]
EOG81VNJ4	GO:0003735	25/96	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG81VNJ4	GO:0015935	25/96	small ribosomal subunit	cellular_component	"The smaller of the two subunits of a ribosome." [GOC:mah]
EOG81VNJ4	GO:0003723	25/96	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG81VNJ4	GO:0006412	24/96	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG81VNJ4	GO:0006974	1/96	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG81VNJ4	GO:0043524	1/96	negative regulation of neuron apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
EOG81VNJ4	GO:0000737	1/96	DNA catabolic process, endonucleolytic	biological_process	"The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
EOG81VNJ4	GO:0006281	1/96	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG81VNJ4	GO:0003906	1/96	DNA-(apurinic or apyrimidinic site) lyase activity	molecular_function	"Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18]
EOG81VNJ4	GO:0005840	1/96	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG81VNJ4	GO:0006810	1/96	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG81VNJ4	GO:0032088	1/96	negative regulation of NF-kappaB transcription factor activity	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb]
EOG81VNJ4	GO:0007067	1/96	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG81VNJ4	GO:0002181	1/96	cytoplasmic translation	biological_process	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]
EOG81VNJ4	GO:0016021	1/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81VNJ4	GO:0005875	1/96	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG81VNJ4	GO:0008534	1/96	oxidized purine nucleobase lesion DNA N-glycosylase activity	molecular_function	"Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296]
EOG81VNJ4	GO:0005634	1/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81VNJ4	GO:0016363	1/96	nuclear matrix	cellular_component	"The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]
EOG80308M	GO:0005634	28/112	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80308M	GO:0003707	25/112	steroid hormone receptor activity	molecular_function	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
EOG80308M	GO:0043565	22/112	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG80308M	GO:0008270	22/112	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80308M	GO:0003700	15/112	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG80308M	GO:0004879	14/112	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	molecular_function	"Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH]
EOG80308M	GO:0006351	14/112	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG80308M	GO:0003677	5/112	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80308M	GO:0048047	1/112	mating behavior, sex discrimination	biological_process	"The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700]
EOG80308M	GO:0007530	1/112	sex determination	biological_process	"Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732]
EOG80308M	GO:0018991	1/112	oviposition	biological_process	"The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems]
EOG80308M	GO:0008049	1/112	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG80308M	GO:0045924	1/112	regulation of female receptivity	biological_process	"Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:go_curators, GOC:tb]
EOG80308M	GO:0000122	1/112	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG80308M	GO:0018993	1/112	somatic sex determination	biological_process	"The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems]
EOG80308M	GO:0030522	1/112	intracellular receptor signaling pathway	biological_process	"Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah]
EOG80308M	GO:0007620	1/112	copulation	biological_process	"The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544]
EOG80308M	GO:0001078	1/112	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
EOG80308M	GO:0007619	1/112	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG80308M	GO:0035206	1/112	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8DV81C	GO:0016740	2/140	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8T1M29	GO:0007059	1/40	chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
EOG8T1M29	GO:0046872	1/40	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8T1M29	GO:0034508	1/40	centromere complex assembly	biological_process	"The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw]
EOG8T1M29	GO:0003676	1/40	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG803061	GO:0006511	31/105	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG803061	GO:0008234	26/105	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG803061	GO:0016579	1/105	protein deubiquitination	biological_process	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]
EOG803061	GO:0035328	1/105	transcriptionally silent chromatin	cellular_component	"The ordered and organized complex of DNA and protein that forms regions of the chromosome that are not being actively transcribed." [GOC:sart, PMID:17965872]
EOG803061	GO:0008233	1/105	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG803061	GO:0005634	1/105	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG803061	GO:0016578	1/105	histone deubiquitination	biological_process	"The modification of histones by removal of ubiquitin groups." [GOC:ai]
EOG803061	GO:0006342	1/105	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG803061	GO:0005700	1/105	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG803061	GO:0043234	1/105	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG803061	GO:0004843	1/105	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG803065	GO:0005525	26/90	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG803065	GO:0003924	26/90	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG803065	GO:0005739	12/90	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG803065	GO:0032543	12/90	mitochondrial translation	biological_process	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]
EOG803065	GO:0032790	12/90	ribosome disassembly	biological_process	"The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk]
EOG803065	GO:0006184	12/90	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG803065	GO:0003746	3/90	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG8HTCB9	GO:0016500	1/2	protein-hormone receptor activity	molecular_function	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]
EOG8HTCB9	GO:0016021	1/2	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8935ZZ	GO:0008234	5/251	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8935ZZ	GO:0015074	1/251	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8935ZZ	GO:0003964	1/251	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8935ZZ	GO:0003723	1/251	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8935ZZ	GO:0003676	1/251	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80CKZ3	GO:0015031	1/84	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG80CKZ3	GO:0008289	1/84	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG80CKZ3	GO:0007399	1/84	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG80CKZ3	GO:0004114	1/84	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular_function	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]
EOG8935ZS	GO:0005634	8/42	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8935ZS	GO:0006260	8/42	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8935ZW	GO:0045454	10/90	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8935ZK	GO:0009186	30/92	deoxyribonucleoside diphosphate metabolic process	biological_process	"The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
EOG8935ZK	GO:0016491	26/92	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8935ZK	GO:0004748	4/92	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	molecular_function	"Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1]
EOG8935ZK	GO:0006260	1/92	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8935ZK	GO:0005737	1/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8935ZK	GO:0006919	1/92	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
EOG8935ZK	GO:0022008	1/92	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8935ZK	GO:0046872	1/92	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XWJFT	GO:0003676	1/13	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8D55BK	GO:0005524	25/102	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8D55BK	GO:0004674	24/102	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8D55BK	GO:0007165	23/102	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8D55BK	GO:0004697	2/102	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG8D55BK	GO:0006468	1/102	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8D55BK	GO:0016301	1/102	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8D55BK	GO:0046777	1/102	protein autophosphorylation	biological_process	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
EOG8D55BK	GO:0030054	1/102	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8D55BK	GO:0090303	1/102	positive regulation of wound healing	biological_process	"Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF]
EOG8D55BK	GO:0005515	1/102	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8D55BK	GO:0005634	1/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D55BK	GO:0016020	1/102	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8D55BK	GO:0032154	1/102	cleavage furrow	cellular_component	"In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409]
EOG8D55BK	GO:0030027	1/102	lamellipodium	cellular_component	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]
EOG8D55BK	GO:0006355	1/102	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8D55BK	GO:0030496	1/102	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG8D55BK	GO:0007472	1/102	wing disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8D55BK	GO:0005856	1/102	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8D55BK	GO:0031532	1/102	actin cytoskeleton reorganization	biological_process	"A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]
EOG8D55BK	GO:0006351	1/102	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8D55BK	GO:0007391	1/102	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8D55BK	GO:0007049	1/102	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG8D55BK	GO:0004672	1/102	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8D55BK	GO:0007155	1/102	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8D55BK	GO:0005737	1/102	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8D55BK	GO:0003676	1/102	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8D55BK	GO:0051301	1/102	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8HDW7R	GO:0009058	6/20	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG8HDW7R	GO:0004397	5/20	histidine ammonia-lyase activity	molecular_function	"Catalysis of the reaction: L-histidine = urocanate + NH3." [EC:4.3.1.3]
EOG8HDW7R	GO:0019556	5/20	histidine catabolic process to glutamate and formamide	biological_process	"The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide." [GOC:go_curators]
EOG8HDW7R	GO:0019557	5/20	histidine catabolic process to glutamate and formate	biological_process	"The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate." [GOC:go_curators]
EOG8HDW7R	GO:0005737	5/20	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HDW7R	GO:0005215	1/20	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8HDW7R	GO:0016021	1/20	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HDW7R	GO:0016841	1/20	ammonia-lyase activity	molecular_function	"Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate." [EC:4.3.-.-, GOC:krc]
EOG8D55BN	GO:0004222	86/312	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8D55BN	GO:0006508	2/312	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8D55BN	GO:0004175	2/312	endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8D55BN	GO:0016021	1/312	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D55BN	GO:0016529	1/312	sarcoplasmic reticulum	cellular_component	"A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage." [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684]
EOG8D55BN	GO:0005615	1/312	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8HDW7V	GO:0007155	26/98	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8HDW7V	GO:0004222	26/98	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8HDW7V	GO:0016020	26/98	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HDW7V	GO:0005737	2/98	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HDW7V	GO:0008406	2/98	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG8HDW7V	GO:0007100	2/98	mitotic centrosome separation	biological_process	"Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194]
EOG8HDW7V	GO:0007052	2/98	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8HDW7V	GO:0008233	2/98	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8HDW7V	GO:0045842	2/98	positive regulation of mitotic metaphase/anaphase transition	biological_process	"Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
EOG8HDW7V	GO:0006338	2/98	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG8HDW7V	GO:0003676	2/98	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HDW7V	GO:0008354	2/98	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8HDW7V	GO:0046872	2/98	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HDW7V	GO:0051298	2/98	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8HDW7V	GO:0007420	2/98	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG8HDW7V	GO:0007076	2/98	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8HDW7V	GO:0008270	2/98	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8HDW7V	GO:0007444	2/98	imaginal disc development	biological_process	"The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238]
EOG8HDW7V	GO:0031252	1/98	cell leading edge	cellular_component	"The area of a motile cell closest to the direction of movement." [GOC:pg]
EOG8PVRDN	GO:0005634	27/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PVRDN	GO:0003700	27/90	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8PVRDN	GO:0043565	27/90	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8PVRDN	GO:0008270	27/90	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PVRDN	GO:0016740	2/90	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8PVRDN	GO:0008045	1/90	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8PVRDN	GO:0051726	1/90	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8PVRDN	GO:0007399	1/90	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8Z91CT	GO:0043565	37/124	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8Z91CT	GO:0003700	37/124	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z91CT	GO:0005634	30/124	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z91CT	GO:0032504	1/124	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8Z91CT	GO:0005615	1/124	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8Z91CT	GO:0030154	1/124	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8Z91CT	GO:0007399	1/124	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8Z91CT	GO:0006351	1/124	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG82VBX2	GO:0007264	37/113	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG82VBX2	GO:0005085	36/113	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG82VBX2	GO:0000166	1/113	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG82VBX2	GO:0046872	1/113	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82VBX2	GO:0003723	1/113	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG82VBX2	GO:0032319	1/113	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG82VBX2	GO:0035023	1/113	regulation of Rho protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]
EOG82VBX2	GO:0005634	1/113	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82VBX2	GO:0005089	1/113	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG82VBX2	GO:0003824	1/113	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG87DCVX	GO:0035556	9/125	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG87DCVX	GO:0008270	1/125	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87DCVX	GO:0003964	1/125	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG87DCVX	GO:0003723	1/125	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG87DCVX	GO:0035859	1/125	Seh1-associated complex	cellular_component	"A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883, PMID:23974112]
EOG80P6ND	GO:0016021	230/726	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6ND	GO:0022891	177/726	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG80P6ND	GO:0022857	38/726	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG80P6ND	GO:0008643	18/726	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG80P6ND	GO:0005886	18/726	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80P6ND	GO:0015771	15/726	trehalose transport	biological_process	"The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai]
EOG80P6ND	GO:0015574	15/726	trehalose transmembrane transporter activity	molecular_function	"Enables the transfer of trehalose from one side of the membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
EOG80P6ND	GO:0032440	8/726	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG80P6ND	GO:0016020	2/726	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG80P6ND	GO:0046427	1/726	positive regulation of JAK-STAT cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG86MF03	GO:0016324	1/64	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG86MF03	GO:0007370	1/64	ventral furrow formation	biological_process	"Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238]
EOG8WSZR4	GO:0003676	24/91	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WSZR4	GO:0004523	22/91	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8WSZR4	GO:0005524	1/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WSZR4	GO:0003723	1/91	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8WSZR4	GO:0003964	1/91	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8WSZR4	GO:0004386	1/91	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG866Z3P	GO:0003796	77/179	lysozyme activity	molecular_function	"Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17]
EOG866Z3P	GO:0005576	1/179	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG866Z3P	GO:0008061	1/179	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG866Z3P	GO:0006030	1/179	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG866Z3P	GO:0032504	1/179	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG866Z3P	GO:0005615	1/179	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8D55BT	GO:0008270	23/93	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D55BT	GO:0005524	22/93	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8D55BT	GO:0004672	21/93	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8D55BT	GO:0006468	1/93	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8D55BT	GO:0016301	1/93	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8D55BT	GO:0004715	1/93	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8D55BT	GO:0004709	1/93	MAP kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
EOG8D55BT	GO:0001737	1/93	establishment of imaginal disc-derived wing hair orientation	biological_process	"Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]
EOG8D55BT	GO:0030496	1/93	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG8D55BT	GO:0005938	1/93	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8D55BT	GO:0032154	1/93	cleavage furrow	cellular_component	"In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409]
EOG8D55BT	GO:0004674	1/93	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8D55BT	GO:0048749	1/93	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8D55BT	GO:0001736	1/93	establishment of planar polarity	biological_process	"Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
EOG8D55BT	GO:0005737	1/93	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8D55BT	GO:0007416	1/93	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG8D55BT	GO:0048812	1/93	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8D55BT	GO:0051124	1/93	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8D55BT	GO:0030036	1/93	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8D55BT	GO:0050770	1/93	regulation of axonogenesis	biological_process	"Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]
EOG8D55BT	GO:0007560	1/93	imaginal disc morphogenesis	biological_process	"The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid]
EOG8D55BT	GO:0005826	1/93	actomyosin contractile ring	cellular_component	"A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, ISBN:0805319409, ISBN:0815316194]
EOG8D55BT	GO:0019901	1/93	protein kinase binding	molecular_function	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]
EOG80VZ3D	GO:0006486	28/99	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG80VZ3D	GO:0003980	28/99	UDP-glucose:glycoprotein glucosyltransferase activity	molecular_function	"Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [GOC:al, PMID:10764828]
EOG80VZ3D	GO:0005635	1/99	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG80VZ3D	GO:0005791	1/99	rough endoplasmic reticulum	cellular_component	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]
EOG80VZ3D	GO:0005783	1/99	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG80VZ3D	GO:0005737	1/99	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG80VZ3D	GO:0097359	1/99	UDP-glucosylation	biological_process	"The covalent attachment of a UDP-glucose residue to a substrate molecule." [GOC:al]
EOG80VZ3D	GO:0005788	1/99	endoplasmic reticulum lumen	cellular_component	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]
EOG80VZ3B	GO:0007155	20/104	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG80VZ3B	GO:0005606	17/104	laminin-1 complex	cellular_component	"A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
EOG80VZ3B	GO:0045995	17/104	regulation of embryonic development	biological_process	"Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators]
EOG80VZ3B	GO:0030334	17/104	regulation of cell migration	biological_process	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]
EOG80VZ3B	GO:0030155	17/104	regulation of cell adhesion	biological_process	"Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah]
EOG80VZ3B	GO:0005604	5/104	basement membrane	cellular_component	"A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]
EOG80VZ3B	GO:0004714	2/104	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG80VZ3B	GO:0001964	1/104	startle response	biological_process	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
EOG80VZ3B	GO:0036062	1/104	presynaptic periactive zone	cellular_component	"A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development." [GOC:sart, PMID:10976048, PMID:18439406]
EOG80VZ3B	GO:0016321	1/104	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG80VZ3B	GO:0007411	1/104	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG80VZ3B	GO:0005605	1/104	basal lamina	cellular_component	"A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix." [ISBN:0198547684]
EOG80VZ3B	GO:0035011	1/104	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG80VZ3B	GO:0045886	1/104	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG80VZ3B	GO:0008021	1/104	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG80VZ3B	GO:0035001	1/104	dorsal trunk growth, open tracheal system	biological_process	"Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system." [GOC:mtg_sensu, ISBN:0879694238]
EOG80VZ3B	GO:0007507	1/104	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG80VZ3B	GO:0007476	1/104	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG80VZ3B	GO:0030054	1/104	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG80VZ3B	GO:0007498	1/104	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG80VZ3B	GO:0030424	1/104	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG80VZ3B	GO:0002121	1/104	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG80VZ3B	GO:0048854	1/104	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG80VZ3B	GO:0031987	1/104	locomotion involved in locomotory behavior	biological_process	"Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
EOG8S1WQM	GO:0005634	12/62	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8S1WQM	GO:0003700	12/62	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z91BM	GO:0005272	54/138	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8Z91BM	GO:0016021	53/138	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z91BM	GO:0051536	2/138	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8Z91BM	GO:0004252	2/138	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8Z91BM	GO:0016020	1/138	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Z91BM	GO:0000439	1/138	core TFIIH complex	cellular_component	"The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015]
EOG8Z91BM	GO:0006289	1/138	nucleotide-excision repair	biological_process	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]
EOG8Z91BM	GO:0006355	1/138	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82VBX8	GO:0005215	5/52	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG82VBX8	GO:0005622	5/52	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG818F46	GO:0008270	1/173	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG818F46	GO:0003682	1/173	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG818F46	GO:0003676	1/173	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG818F41	GO:0005509	8/88	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG88973M	GO:0005874	1/80	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG88973M	GO:0005525	1/80	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG88973M	GO:0004930	1/80	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG88973M	GO:0007017	1/80	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG88973M	GO:0016020	1/80	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8H74S9	GO:0016020	26/100	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8H74S9	GO:0008654	24/100	phospholipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8H74S9	GO:0016780	23/100	phosphotransferase activity, for other substituted phosphate groups	molecular_function	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]
EOG8H74S9	GO:0004142	2/100	diacylglycerol cholinephosphotransferase activity	molecular_function	"Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2]
EOG8H74S9	GO:0004307	1/100	ethanolaminephosphotransferase activity	molecular_function	"Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [EC:2.7.8.1]
EOG8H74S9	GO:0016740	1/100	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG88973C	GO:0008270	24/187	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG88973C	GO:0003676	23/187	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88973C	GO:0005634	2/187	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88973C	GO:0004190	1/187	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG88973C	GO:0016891	1/187	endoribonuclease activity, producing 5'-phosphomonoesters	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
EOG88973C	GO:0003700	1/187	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG88973C	GO:0003677	1/187	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG818F4B	GO:0003677	1/29	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8PRW6H	GO:0042384	1/69	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8HB10R	GO:0007155	28/106	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8HB10R	GO:0005198	28/106	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8HB10R	GO:0015629	28/106	actin cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
EOG8HB10R	GO:0003779	1/106	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8B8MX0	GO:0003899	22/57	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8B8MX0	GO:0003677	22/57	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8B8MX0	GO:0006351	21/57	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8B8MX0	GO:0006366	1/57	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8B8MX0	GO:0005736	1/57	DNA-directed RNA polymerase I complex	cellular_component	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8B8MX0	GO:0006383	1/57	transcription from RNA polymerase III promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH]
EOG8B8MX0	GO:0005666	1/57	DNA-directed RNA polymerase III complex	cellular_component	"RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8B8MX0	GO:0005665	1/57	DNA-directed RNA polymerase II, core complex	cellular_component	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8B8MX0	GO:0006360	1/57	transcription from RNA polymerase I promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
EOG8QVFT8	GO:0006869	21/119	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG8QVFT8	GO:0033868	2/119	Goodpasture-antigen-binding protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein." [EC:2.7.11.9]
EOG8QVFT8	GO:0006886	1/119	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8QVFT8	GO:0005524	1/119	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QVFT8	GO:0007291	1/119	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8QVFT8	GO:0005783	1/119	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8QVFT8	GO:0004672	1/119	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8QVFT8	GO:0005794	1/119	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8QVFT8	GO:0007030	1/119	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8HB10Z	GO:0016740	2/151	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8HB10Z	GO:0010378	1/151	temperature compensation of the circadian clock	biological_process	"The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099]
EOG8HB10Z	GO:0031514	1/151	motile cilium	cellular_component	"A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998]
EOG8HB10Z	GO:0060285	1/151	cilium-dependent cell motility	biological_process	"Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013]
EOG8HB10Z	GO:0005737	1/151	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HB10Z	GO:0045433	1/151	male courtship behavior, veined wing generated song production	biological_process	"The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
EOG8HB10Z	GO:0035082	1/151	axoneme assembly	biological_process	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]
EOG8HB10Z	GO:0030425	1/151	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8HB10Z	GO:0007605	1/151	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8QC3M6	GO:0016021	25/63	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QC3M6	GO:0055085	21/63	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8QC3M6	GO:1902559	4/63	3'-phospho-5'-adenylyl sulfate transmembrane transport	biological_process	"The directed movement of 3'-phospho-5'-adenylyl sulfate across a membrane." [GOC:TermGenie, PMID:24296033]
EOG8QC3M6	GO:0005794	4/63	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8QC3M6	GO:0046963	4/63	3'-phosphoadenosine 5'-phosphosulfate transport	biological_process	"The directed movement of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
EOG8QC3M6	GO:0007275	4/63	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8QC3M6	GO:0000139	4/63	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8QC3M6	GO:0046964	4/63	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	molecular_function	"Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other." [ISBN:0198506732]
EOG8QC3M6	GO:0005783	1/63	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8QC3M6	GO:0015012	1/63	heparan sulfate proteoglycan biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210]
EOG8QC3M6	GO:0000137	1/63	Golgi cis cisterna	cellular_component	"The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194]
EOG8QC3M4	GO:0008270	27/93	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8QC3M4	GO:0006355	26/93	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8QC3M4	GO:0006352	26/93	DNA-templated transcription, initiation	biological_process	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]
EOG8QC3M4	GO:0003743	3/93	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8QC3M4	GO:0005634	2/93	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8QC3M4	GO:0001174	1/93	transcriptional start site selection at RNA polymerase II promoter	biological_process	"Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104]
EOG8QC3M4	GO:0006357	1/93	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8QC3M4	GO:0051101	1/93	regulation of DNA binding	biological_process	"Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb]
EOG8QC3M4	GO:0006367	1/93	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG8QC3M4	GO:0005667	1/93	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8QC3M4	GO:0008134	1/93	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8QC3M4	GO:0005515	1/93	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8WSZRC	GO:0005794	22/85	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8WSZRC	GO:0007030	1/85	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8WSZRC	GO:0048193	1/85	Golgi vesicle transport	biological_process	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG8WSZRC	GO:0005783	1/85	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8WSZRC	GO:0005795	1/85	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG8WSZRC	GO:0032440	1/85	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8WSZRC	GO:0000137	1/85	Golgi cis cisterna	cellular_component	"The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194]
EOG8WSZRC	GO:0017137	1/85	Rab GTPase binding	molecular_function	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG866Z30	GO:0034587	1/86	piRNA metabolic process	biological_process	"The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]
EOG866Z30	GO:0046331	1/86	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG866Z30	GO:0005739	1/86	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG87SVXQ	GO:0006412	22/69	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG87SVXQ	GO:0005840	4/69	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG87SVXQ	GO:0003735	2/69	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG87SVXQ	GO:0005739	2/69	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG87SVXQ	GO:0005762	1/69	mitochondrial large ribosomal subunit	cellular_component	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
EOG876NDT	GO:0003677	8/55	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG876NDT	GO:0006310	2/55	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG876NDT	GO:0015074	2/55	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG876NDT	GO:0003676	1/55	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NKFB8	GO:0004089	104/367	carbonate dehydratase activity	molecular_function	"Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1]
EOG8NKFB8	GO:0006730	100/367	one-carbon metabolic process	biological_process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
EOG8NKFB8	GO:0008270	99/367	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NKFB8	GO:0031233	1/367	intrinsic component of external side of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah]
EOG876NDC	GO:0016787	24/115	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG876NDC	GO:0052689	3/115	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG876NDC	GO:0003990	2/115	acetylcholinesterase activity	molecular_function	"Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
EOG876NDC	GO:0004104	1/115	cholinesterase activity	molecular_function	"Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8]
EOG876NDB	GO:0005524	142/420	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG876NDB	GO:0006950	24/420	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG876NDB	GO:0005875	8/420	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG876NDB	GO:0009408	7/420	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG876NDB	GO:0032440	7/420	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG876NDB	GO:0001666	6/420	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG876NDB	GO:0035080	6/420	heat shock-mediated polytene chromosome puffing	biological_process	"The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus." [GOC:bf, PMID:12543962]
EOG876NDB	GO:0006986	4/420	response to unfolded protein	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl]
EOG876NDB	GO:0005811	3/420	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG876NDB	GO:0005515	2/420	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG876NDB	GO:0031427	2/420	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG876NDB	GO:0016021	1/420	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG876NDB	GO:0031209	1/420	SCAR complex	cellular_component	"A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:pg, PMID:12181570]
EOG876NDB	GO:0042594	1/420	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG876NDB	GO:0005634	1/420	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG876NDB	GO:0006909	1/420	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG876NDB	GO:0007528	1/420	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG876NDB	GO:0007010	1/420	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG876NDB	GO:0030866	1/420	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG876NDB	GO:0007520	1/420	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG876NDB	GO:0000902	1/420	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG876NDB	GO:0048471	1/420	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG876NDB	GO:0030031	1/420	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG876NDB	GO:0008407	1/420	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG876NDB	GO:0008360	1/420	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG876NDB	GO:0008340	1/420	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG876NDB	GO:0001764	1/420	neuron migration	biological_process	"The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]
EOG876NDB	GO:0005886	1/420	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG876NDB	GO:0007417	1/420	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG876NDB	GO:0030036	1/420	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG876NDB	GO:0007409	1/420	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG876NDB	GO:0022008	1/420	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG876NDD	GO:0016021	46/177	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG876NDD	GO:0005886	39/177	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG876NDD	GO:0004948	27/177	calcitonin receptor activity	molecular_function	"Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:21649645]
EOG876NDD	GO:0004930	21/177	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG876NDD	GO:0008188	2/177	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG876NDD	GO:0007186	2/177	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG876NDD	GO:0007218	2/177	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG876NDD	GO:0016020	2/177	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG876NDD	GO:0005887	1/177	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG876NDD	GO:0009755	1/177	hormone-mediated signaling pathway	biological_process	"A series of molecular signals mediated by the detection of a hormone." [GOC:sm]
EOG876NDD	GO:0008036	1/177	diuretic hormone receptor activity	molecular_function	"Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling]
EOG876NDD	GO:0008049	1/177	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG89GNZ9	GO:0046907	15/96	intracellular transport	biological_process	"The directed movement of substances within a cell." [GOC:ai]
EOG89GNZ9	GO:0008258	1/96	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG89GNZ9	GO:0007303	1/96	cytoplasmic transport, nurse cell to oocyte	biological_process	"The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238]
EOG89GNZ9	GO:0048813	1/96	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG89GNZ9	GO:0051489	1/96	regulation of filopodium assembly	biological_process	"Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG89GNZ9	GO:0007010	1/96	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG89GNZ9	GO:0005912	1/96	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG89GNZ9	GO:0010591	1/96	regulation of lamellipodium assembly	biological_process	"Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG89GNZ9	GO:0030027	1/96	lamellipodium	cellular_component	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]
EOG89GNZ9	GO:0007015	1/96	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG89GNZ9	GO:0017124	1/96	SH3 domain binding	molecular_function	"Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]
EOG89GNZ9	GO:0005856	1/96	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG89GNZ9	GO:0035262	1/96	gonad morphogenesis	biological_process	"The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001]
EOG89GNZ9	GO:0007391	1/96	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG89GNZ9	GO:0007411	1/96	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG89GNZ9	GO:0007298	1/96	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG89GNZ9	GO:0032433	1/96	filopodium tip	cellular_component	"The end of a filopodium distal to the body of the cell." [GOC:mah]
EOG89GNZ9	GO:0051491	1/96	positive regulation of filopodium assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG89GNZ9	GO:0008360	1/96	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG89GNZ9	GO:0008064	1/96	regulation of actin polymerization or depolymerization	biological_process	"Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]
EOG89GNZ9	GO:0005911	1/96	cell-cell junction	cellular_component	"A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah]
EOG89GNZ9	GO:0031346	1/96	positive regulation of cell projection organization	biological_process	"Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
EOG89GNZ9	GO:0030335	1/96	positive regulation of cell migration	biological_process	"Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]
EOG89GNZ9	GO:0060288	1/96	formation of a compartment boundary	biological_process	"Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph]
EOG89GNZ9	GO:0005515	1/96	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG89GNZ9	GO:0007390	1/96	germ-band shortening	biological_process	"The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138]
EOG89GNZ9	GO:0048749	1/96	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG89GNZ9	GO:0030424	1/96	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG89GNZ9	GO:0031252	1/96	cell leading edge	cellular_component	"The area of a motile cell closest to the direction of movement." [GOC:pg]
EOG89GNZ9	GO:0007396	1/96	suture of dorsal opening	biological_process	"Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138]
EOG89GNZ9	GO:0030036	1/96	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG89GNZ9	GO:0003779	1/96	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG89GNZ9	GO:0003382	1/96	epithelial cell morphogenesis	biological_process	"The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG89GNZ9	GO:0005829	1/96	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG89GNZ9	GO:0007409	1/96	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG86T5GX	GO:0008137	44/138	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG86T5GX	GO:0048038	43/138	quinone binding	molecular_function	"Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732]
EOG86T5GX	GO:0051539	43/138	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG86T5GX	GO:0046872	43/138	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG86T5GX	GO:0032981	1/138	mitochondrial respiratory chain complex I assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]
EOG86T5GX	GO:0051536	1/138	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG86T5GX	GO:0000302	1/138	response to reactive oxygen species	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc]
EOG86T5GX	GO:0008340	1/138	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8323FR	GO:0003677	7/32	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GXJ29	GO:0004252	23/97	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8GXJ29	GO:0006508	1/97	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8J3ZWT	GO:0004736	27/113	pyruvate carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847]
EOG8J3ZWT	GO:0006094	27/113	gluconeogenesis	biological_process	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]
EOG8J3ZWT	GO:0005524	27/113	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8J3ZWT	GO:0003677	27/113	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8J3ZWT	GO:0004075	27/113	biotin carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]
EOG8J3ZWT	GO:0046872	26/113	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8J3ZWT	GO:0005875	1/113	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8J3ZWT	GO:0016829	1/113	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8J3ZWT	GO:0003824	1/113	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8J3ZWT	GO:0005811	1/113	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG89S8Q2	GO:0008270	13/25	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MSGBZ	GO:0005509	37/188	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8MSGBZ	GO:0016787	4/188	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8MSGBZ	GO:0030170	1/188	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8MSGBZ	GO:0008890	1/188	glycine C-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+)." [EC:2.3.1.29, RHEA:20739]
EOG8MSGBZ	GO:0097206	1/188	nephrocyte filtration	biological_process	"The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929]
EOG8MSGBZ	GO:0005875	1/188	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8MSGBZ	GO:0004714	1/188	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8MSGBZ	GO:0009058	1/188	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG86T5GG	GO:0004252	12/41	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8J3ZWZ	GO:0051960	1/95	regulation of nervous system development	biological_process	"Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
EOG8J3ZWZ	GO:0005515	1/95	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8J3ZWZ	GO:0045179	1/95	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8J3ZWZ	GO:0061382	1/95	Malpighian tubule tip cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells." [GOC:dph, GOC:mtg_kidney_jan10, PMID:7821213]
EOG8J3ZWZ	GO:0008356	1/95	asymmetric cell division	biological_process	"The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
EOG8J3ZWZ	GO:0045176	1/95	apical protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf]
EOG8J3ZWZ	GO:0005938	1/95	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8J3ZWZ	GO:0050829	1/95	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8J3ZWZ	GO:0055059	1/95	asymmetric neuroblast division	biological_process	"The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
EOG8J3ZWZ	GO:0040001	1/95	establishment of mitotic spindle localization	biological_process	"The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai]
EOG8J3ZWZ	GO:0008093	1/95	cytoskeletal adaptor activity	molecular_function	"The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07]
EOG8J3ZWZ	GO:0007422	1/95	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8J3ZWZ	GO:0045177	1/95	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8J3ZWZ	GO:0007400	1/95	neuroblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
EOG8J3ZWZ	GO:0007423	1/95	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8J3ZWZ	GO:0045175	1/95	basal protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf]
EOG8J3ZWZ	GO:0005737	1/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8J3ZWZ	GO:0007525	1/95	somatic muscle development	biological_process	"The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
EOG8J3ZWZ	GO:0045167	1/95	asymmetric protein localization involved in cell fate determination	biological_process	"Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai]
EOG8J3ZWZ	GO:0008104	1/95	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8J3ZWZ	GO:0008105	1/95	asymmetric protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma]
EOG8J3ZWZ	GO:0009786	1/95	regulation of asymmetric cell division	biological_process	"Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr]
EOG8J3ZWZ	GO:0006403	1/95	RNA localization	biological_process	"A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai]
EOG86T5G7	GO:0016491	31/106	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG86T5G7	GO:0004303	2/106	estradiol 17-beta-dehydrogenase activity	molecular_function	"Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62]
EOG8GXJ2F	GO:0008270	25/110	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GXJ2F	GO:0019706	25/110	protein-cysteine S-palmitoyltransferase activity	molecular_function	"Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule." [EC:2.3.1.225, GOC:ai, GOC:pr]
EOG8GXJ2F	GO:0016021	25/110	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GXJ2F	GO:0016491	1/110	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8GXJ2F	GO:0018345	1/110	protein palmitoylation	biological_process	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]
EOG8GXJ2F	GO:0005886	1/110	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8GXJ2H	GO:0007165	1/50	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG876ND9	GO:0003676	2/78	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG876ND9	GO:0015074	2/78	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8WWV1R	GO:0003676	182/2316	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WWV1R	GO:0008270	149/2316	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WWV1R	GO:0003677	110/2316	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8WWV1R	GO:0005634	107/2316	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WWV1R	GO:0015074	83/2316	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8WWV1R	GO:0003964	8/2316	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8WWV1R	GO:0003723	4/2316	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8WWV1R	GO:0004519	4/2316	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8WWV1R	GO:0046872	2/2316	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WWV1R	GO:0004190	1/2316	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8WWV1R	GO:0005524	1/2316	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WWV1R	GO:0008762	1/2316	UDP-N-acetylmuramate dehydrogenase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158]
EOG8WWV1R	GO:0006351	1/2316	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8WWV1R	GO:0050660	1/2316	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8WWV1R	GO:0016043	1/2316	cellular component organization	biological_process	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]
EOG8WWV1R	GO:0016787	1/2316	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8WWV1R	GO:0016491	1/2316	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8FFGHB	GO:0006950	26/583	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8FFGHB	GO:0005212	9/583	structural constituent of eye lens	molecular_function	"The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah]
EOG8FFGHB	GO:0008340	3/583	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8FFGHB	GO:0005875	3/583	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8FFGHB	GO:0010998	2/583	regulation of translational initiation by eIF2 alpha phosphorylation	biological_process	"Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha." [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb]
EOG8FFGHB	GO:0009631	2/583	cold acclimation	biological_process	"Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr]
EOG8FFGHB	GO:0005515	2/583	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FFGHB	GO:0007275	1/583	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8FFGHB	GO:0017022	1/583	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8FFGHB	GO:0042595	1/583	behavioral response to starvation	biological_process	"Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators]
EOG8FFGHB	GO:0009408	1/583	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8FFGHB	GO:0007476	1/583	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8FFGHB	GO:0010506	1/583	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8FFGHB	GO:0003779	1/583	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8FFGHB	GO:0006497	1/583	protein lipidation	biological_process	"The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]
EOG8FFGHB	GO:0001666	1/583	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG8FFGHB	GO:0006979	1/583	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8FFGHB	GO:0031427	1/583	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG8FFGHB	GO:0050832	1/583	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8FFGHB	GO:0042742	1/583	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG83JFP4	GO:0003964	1/6	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG83JFP4	GO:0003723	1/6	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG876ND2	GO:0005524	22/84	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG876ND2	GO:0004383	21/84	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG876ND2	GO:0016021	21/84	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG876ND2	GO:0004672	21/84	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG876ND2	GO:0035556	21/84	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG876ND2	GO:0006351	1/84	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG876ND2	GO:0005634	1/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG876ND2	GO:0003700	1/84	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG876ND2	GO:0043565	1/84	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG876ND2	GO:0008270	1/84	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG876ND2	GO:0004714	1/84	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG876ND2	GO:0003707	1/84	steroid hormone receptor activity	molecular_function	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
EOG876ND6	GO:0005262	69/269	calcium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG876ND6	GO:0016021	63/269	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG876ND6	GO:0016020	5/269	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG876ND6	GO:0005515	3/269	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG876ND6	GO:0006816	3/269	calcium ion transport	biological_process	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG876ND6	GO:0034703	3/269	cation channel complex	cellular_component	"An ion channel complex through which cations pass." [GOC:mah]
EOG876ND6	GO:0050908	3/269	detection of light stimulus involved in visual perception	biological_process	"The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
EOG876ND6	GO:0016028	3/269	rhabdomere	cellular_component	"The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774]
EOG876ND6	GO:0009416	3/269	response to light stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
EOG876ND6	GO:0046982	2/269	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG876ND6	GO:0071454	2/269	cellular response to anoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:mah]
EOG876ND6	GO:0005886	2/269	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG876ND6	GO:0042802	2/269	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG876ND6	GO:0007605	2/269	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG876ND6	GO:0008086	2/269	light-activated voltage-gated calcium channel activity	molecular_function	"Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport]
EOG876ND6	GO:0019722	2/269	calcium-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]
EOG876ND6	GO:0015279	2/269	store-operated calcium channel activity	molecular_function	"A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710]
EOG876ND6	GO:0005261	2/269	cation channel activity	molecular_function	"Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG876ND6	GO:0006812	2/269	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG876ND6	GO:0035997	2/269	rhabdomere microvillus membrane	cellular_component	"The portion of the plasma membrane surrounding a microvillus of a rhabdomere." [GOC:bf, GOC:sart, PMID:14744998]
EOG876ND6	GO:0070588	2/269	calcium ion transmembrane transport	biological_process	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG876ND6	GO:0007603	2/269	phototransduction, visible light	biological_process	"The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
EOG876ND6	GO:0005516	2/269	calmodulin binding	molecular_function	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
EOG876ND6	GO:0016027	2/269	inaD signaling complex	cellular_component	"A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815]
EOG876ND6	GO:0015075	1/269	ion transmembrane transporter activity	molecular_function	"Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
EOG876ND6	GO:0050962	1/269	detection of light stimulus involved in sensory perception	biological_process	"The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." [GOC:ai, GOC:dos]
EOG876ND6	GO:0030425	1/269	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG876ND6	GO:0016787	1/269	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG876ND6	GO:0030246	1/269	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG876ND6	GO:0005622	1/269	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG876ND6	GO:0005874	1/269	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG876ND6	GO:0007608	1/269	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG876ND6	GO:0008104	1/269	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG876ND6	GO:0007589	1/269	body fluid secretion	biological_process	"The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb]
EOG876ND6	GO:0005218	1/269	intracellular ligand-gated calcium channel activity	molecular_function	"Enables the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG876ND6	GO:0030845	1/269	phospholipase C-inhibiting G-protein coupled receptor signaling pathway	biological_process	"A G-protein coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, PMID:8280098]
EOG876ND6	GO:0006811	1/269	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG876ND6	GO:0042803	1/269	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG876ND6	GO:0008355	1/269	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG876ND6	GO:0016740	1/269	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG876ND6	GO:0008377	1/269	light-induced release of internally sequestered calcium ion	biological_process	"The process in which the detection of light triggers the release of internally sequestered calcium ions." [GOC:ai]
EOG876ND6	GO:0000226	1/269	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8TMTFX	GO:0046872	20/75	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TMTFX	GO:0005524	12/75	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8TMTFX	GO:0017111	12/75	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8TMTFX	GO:0004386	2/75	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG84J531	GO:0016491	1/2	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8DBWWW	GO:0004930	5/50	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8DBWWW	GO:0016021	5/50	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DBWWW	GO:0016301	4/50	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8DBWWW	GO:0005524	3/50	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8DBWWW	GO:0046872	1/50	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DBWWW	GO:0003676	1/50	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DBWWW	GO:0005525	1/50	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8DBWWP	GO:0003964	3/58	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8DBWWP	GO:0003723	2/58	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8DBWWP	GO:0004519	1/58	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8ZKN39	GO:0003723	31/120	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8ZKN39	GO:0030529	5/120	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8ZKN39	GO:0019013	4/120	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8ZKN39	GO:0007446	1/120	imaginal disc growth	biological_process	"The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387]
EOG8ZKN39	GO:0035107	1/120	appendage morphogenesis	biological_process	"The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]
EOG8ZKN39	GO:0005737	1/120	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZKN39	GO:0008134	1/120	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8ZKN39	GO:0008283	1/120	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8ZKN39	GO:0005634	1/120	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZKN39	GO:0003729	1/120	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8ZKN39	GO:0000381	1/120	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8ZKN39	GO:0000785	1/120	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG8ZKN39	GO:0045165	1/120	cell fate commitment	biological_process	"The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
EOG8ZKN39	GO:0035062	1/120	omega speckle	cellular_component	"A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439]
EOG8ZKN34	GO:0033227	1/101	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8323CZ	GO:0003677	1/119	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8323CZ	GO:0003676	1/119	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8323CZ	GO:0046872	1/119	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DBWWD	GO:0006228	32/93	UTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732]
EOG8DBWWD	GO:0006241	32/93	CTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]
EOG8DBWWD	GO:0004550	32/93	nucleoside diphosphate kinase activity	molecular_function	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]
EOG8DBWWD	GO:0005524	32/93	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8DBWWD	GO:0006183	32/93	GTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8DBWWD	GO:0005880	2/93	nuclear microtubule	cellular_component	"Any microtubule in the nucleus of a cell." [GOC:mah]
EOG8DBWWD	GO:0000287	2/93	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8DBWWD	GO:0016301	2/93	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8DBWWD	GO:0035152	1/93	regulation of tube architecture, open tracheal system	biological_process	"Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584]
EOG8DBWWD	GO:0005874	1/93	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8DBWWD	GO:0005525	1/93	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8DBWWD	GO:0007424	1/93	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8DBWWD	GO:0005737	1/93	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8DBWWD	GO:0018105	1/93	peptidyl-serine phosphorylation	biological_process	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]
EOG8DBWWD	GO:0007017	1/93	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8DBWWD	GO:0016334	1/93	establishment or maintenance of polarity of follicular epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah]
EOG8DBWWD	GO:0008017	1/93	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8DBWWD	GO:0007067	1/93	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8DBWWD	GO:0034332	1/93	adherens junction organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah]
EOG8DBWWD	GO:0006165	1/93	nucleoside diphosphate phosphorylation	biological_process	"The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]
EOG8DBWWD	GO:0007427	1/93	epithelial cell migration, open tracheal system	biological_process	"The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8DBWWD	GO:0009117	1/93	nucleotide metabolic process	biological_process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]
EOG8DBWWD	GO:0046777	1/93	protein autophosphorylation	biological_process	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
EOG8DBWWD	GO:0006468	1/93	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8DBWWD	GO:0005875	1/93	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG89W4W6	GO:0005215	16/79	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG89W4W6	GO:0005768	8/79	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG89W4W6	GO:0007040	8/79	lysosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]
EOG89W4W6	GO:0005802	8/79	trans-Golgi network	cellular_component	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]
EOG89W4W6	GO:0030136	8/79	clathrin-coated vesicle	cellular_component	"A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]
EOG89W4W6	GO:0080025	8/79	phosphatidylinositol-3,5-bisphosphate binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]
EOG89W4W6	GO:0005622	8/79	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG89W4W6	GO:0016787	3/79	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8PZMN6	GO:0016020	1/97	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8X0Q69	GO:0008859	2/95	exoribonuclease II activity	molecular_function	"Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684]
EOG8X0Q69	GO:0022008	1/95	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8X0Q69	GO:0071027	1/95	nuclear RNA surveillance	biological_process	"The set of processes involved in identifying and degrading defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]
EOG8X0Q69	GO:0010468	1/95	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8X0Q69	GO:0005634	1/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X0Q69	GO:0000176	1/95	nuclear exosome (RNase complex)	cellular_component	"Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]
EOG8X0Q69	GO:0005652	1/95	nuclear lamina	cellular_component	"The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363]
EOG8MSGCF	GO:0016021	47/174	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8MSGCF	GO:0005234	44/174	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8MSGCF	GO:0030054	42/174	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8MSGCF	GO:0004970	42/174	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8MSGCF	GO:0045211	42/174	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8MSGCF	GO:0035249	2/174	synaptic transmission, glutamatergic	biological_process	"The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv]
EOG8MSGCF	GO:0032281	2/174	AMPA glutamate receptor complex	cellular_component	"An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef]
EOG8MSGCF	GO:0006812	2/174	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8MSGCF	GO:0008328	2/174	ionotropic glutamate receptor complex	cellular_component	"A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
EOG8MSGCF	GO:0034220	2/174	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8MSGCF	GO:0004971	2/174	AMPA glutamate receptor activity	molecular_function	"An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium." [GOC:mah, PMID:10049997, PMID:8804111]
EOG8MSGCF	GO:0005230	2/174	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8MSGCF	GO:0035235	2/174	ionotropic glutamate receptor signaling pathway	biological_process	"A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732]
EOG8MSGCF	GO:0030425	2/174	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8MSGCF	GO:0009253	1/174	peptidoglycan catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
EOG8MSGCF	GO:0016020	1/174	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8MSGCF	GO:0005886	1/174	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8MSGCF	GO:0008745	1/174	N-acetylmuramoyl-L-alanine amidase activity	molecular_function	"Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]
EOG8MSGCF	GO:0005215	1/174	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG87H84V	GO:0005509	1/6	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG87H84V	GO:0005578	1/6	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG87H84V	GO:0005201	1/6	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG8WWV17	GO:0008270	4/198	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WWV17	GO:0005634	2/198	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WWV17	GO:0005524	1/198	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WWV17	GO:0008026	1/198	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8WWV17	GO:0003676	1/198	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JT2PG	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TMTHF	GO:0003676	194/895	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8TMTHF	GO:0003677	58/895	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TMTHF	GO:0004519	19/895	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8TMTHF	GO:0003964	19/895	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8TMTHF	GO:0003723	5/895	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8TMTHF	GO:0015074	3/895	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8TMTHF	GO:0005524	2/895	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8TMTHF	GO:0005525	1/895	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8TMTHF	GO:0006313	1/895	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG8TMTHF	GO:0004736	1/895	pyruvate carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847]
EOG8TMTHF	GO:0006094	1/895	gluconeogenesis	biological_process	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]
EOG8TMTHF	GO:0046872	1/895	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TMTHF	GO:0004075	1/895	biotin carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]
EOG8TMTHF	GO:0004674	1/895	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8TMTHF	GO:0004252	1/895	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8TMTHF	GO:0008270	1/895	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TMTHF	GO:0005634	1/895	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TMTHF	GO:0003924	1/895	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8TMTHF	GO:0016021	1/895	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TMTHF	GO:0004803	1/895	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG8WWV1D	GO:0009968	38/103	negative regulation of signal transduction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]
EOG8WWV1D	GO:0005737	38/103	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WWV1D	GO:0006915	3/103	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8WWV1D	GO:0032006	3/103	regulation of TOR signaling	biological_process	"Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8WWV1D	GO:0008258	3/103	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8WWV1D	GO:0006979	3/103	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8WWV1D	GO:0045926	2/103	negative regulation of growth	biological_process	"Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
EOG8WWV1D	GO:0008219	2/103	cell death	biological_process	"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as \"apoptotic bodies\"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo." [GOC:mah, GOC:mtg_apoptosis]
EOG8WWV1D	GO:0032504	1/103	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8WWV1D	GO:0006974	1/103	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8BS00Z	GO:0005215	1/6	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8BS00V	GO:0003964	1/142	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8BS00V	GO:0003723	1/142	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8NW20Q	GO:0005634	42/146	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NW20Q	GO:0003700	41/146	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NW20Q	GO:0045944	2/146	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8NW20Q	GO:0008063	2/146	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8NW20Q	GO:0035206	2/146	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8NW20Q	GO:0006955	2/146	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8NW20Q	GO:0043565	2/146	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NW20Q	GO:0006952	2/146	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8NW20Q	GO:0001077	2/146	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG8NW20Q	GO:0006964	2/146	positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
EOG8NW20Q	GO:0042387	2/146	plasmatocyte differentiation	biological_process	"The process in which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response." [PMID:11921077, PMID:8174791]
EOG8NW20Q	GO:0005515	2/146	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8NW20Q	GO:0048935	2/146	peripheral nervous system neuron development	biological_process	"The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh]
EOG8NW20Q	GO:0005737	2/146	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8NW20Q	GO:0000381	1/146	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8NW20Q	GO:0006974	1/146	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8NW20Q	GO:0007507	1/146	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8NW20Q	GO:0006967	1/146	positive regulation of antifungal peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah]
EOG8NW20Q	GO:0045893	1/146	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8NW20Q	GO:0009953	1/146	dorsal/ventral pattern formation	biological_process	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8NW20Q	GO:0010629	1/146	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8NW20Q	GO:0010004	1/146	gastrulation involving germ band extension	biological_process	"A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8NW20Q	GO:0010628	1/146	positive regulation of gene expression	biological_process	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8NW20Q	GO:0006366	1/146	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8NW20Q	GO:0050830	1/146	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG8NW20Q	GO:0007498	1/146	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8NW20Q	GO:0035070	1/146	salivary gland histolysis	biological_process	"The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683]
EOG8NW20Q	GO:0000122	1/146	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8NW20Q	GO:0007369	1/146	gastrulation	biological_process	"A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]
EOG8NW20Q	GO:0008354	1/146	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8NW20Q	GO:0009952	1/146	anterior/posterior pattern specification	biological_process	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8NW20Q	GO:0003677	1/146	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NW20Q	GO:0007501	1/146	mesodermal cell fate specification	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
EOG8NW20Q	GO:0002781	1/146	antifungal peptide production	biological_process	"The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
EOG8NW20Q	GO:0009620	1/146	response to fungus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
EOG8NW20Q	GO:0000977	1/146	RNA polymerase II regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
EOG8NW20Q	GO:0009950	1/146	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8NW20Q	GO:0007398	1/146	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG8NW20Q	GO:0070491	1/146	repressing transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH]
EOG8NW20Q	GO:0031594	1/146	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8NW20Q	GO:0045087	1/146	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8NW20Q	GO:0001715	1/146	ectodermal cell fate specification	biological_process	"The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
EOG8NW20Q	GO:0006355	1/146	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8NW20Q	GO:0050832	1/146	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8NW20Q	GO:0007419	1/146	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8NW20Q	GO:0070379	1/146	high mobility group box 1 binding	molecular_function	"Interacting selectively and non-covalently with high mobility group box 1 (HMBGB1)." [GOC:add, PMID:18431461]
EOG8NW20Q	GO:0045892	1/146	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8NW20Q	GO:0035006	1/146	melanization defense response	biological_process	"The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809]
EOG8NW20Q	GO:0035171	1/146	lamellocyte differentiation	biological_process	"The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104]
EOG8FTZGW	GO:0005634	3/133	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FTZGW	GO:0016925	2/133	protein sumoylation	biological_process	"The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250]
EOG8FTZGW	GO:0055088	1/133	lipid homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]
EOG8FTZGW	GO:0043406	1/133	positive regulation of MAP kinase activity	biological_process	"Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]
EOG8FTZGW	GO:0006909	1/133	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8FTZGW	GO:0035073	1/133	pupariation	biological_process	"The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
EOG8FTZGW	GO:0005515	1/133	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FTZGW	GO:0006099	1/133	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8FTZGW	GO:0035186	1/133	syncytial blastoderm mitotic cell cycle	biological_process	"Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238]
EOG8FTZGW	GO:0000278	1/133	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8FTZGW	GO:0071560	1/133	cellular response to transforming growth factor beta stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575]
EOG8FTZGW	GO:0021952	1/133	central nervous system projection neuron axonogenesis	biological_process	"Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8FTZGW	GO:0046579	1/133	positive regulation of Ras protein signal transduction	biological_process	"Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
EOG8FTZGW	GO:0060997	1/133	dendritic spine morphogenesis	biological_process	"The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
EOG8FTZGW	GO:0030496	1/133	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG8FTZGW	GO:0000780	1/133	condensed nuclear chromosome, centromeric region	cellular_component	"The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
EOG8FTZGW	GO:0005730	1/133	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8FTZGW	GO:0006464	1/133	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG8FTZGW	GO:0006606	1/133	protein import into nucleus	biological_process	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]
EOG8FTZGW	GO:0000940	1/133	condensed chromosome outer kinetochore	cellular_component	"The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983]
EOG8FTZGW	GO:0016926	1/133	protein desumoylation	biological_process	"The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250]
EOG8FTZGW	GO:0007052	1/133	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8FTZGW	GO:0000794	1/133	condensed nuclear chromosome	cellular_component	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh]
EOG8FTZGW	GO:0046843	1/133	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8NW20M	GO:0016491	1/7	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8BS00N	GO:0016021	46/215	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BS00N	GO:0015377	45/215	cation:chloride symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [TC:2.A.30.-.-]
EOG8BS00N	GO:0016020	21/215	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8BS00N	GO:0055085	20/215	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8BS00N	GO:0015171	2/215	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8BS00N	GO:0005215	2/215	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8BS00N	GO:0003333	2/215	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG8BS00N	GO:0006811	2/215	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8BS00N	GO:1902476	1/215	chloride transmembrane transport	biological_process	"The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw]
EOG8BS00N	GO:0008511	1/215	sodium:potassium:chloride symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)." [TC:2.A.30.1.1]
EOG8BS00N	GO:0006821	1/215	chloride transport	biological_process	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8BS00N	GO:0005886	1/215	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8BS00N	GO:0035826	1/215	rubidium ion transport	biological_process	"The directed movement of rubidium ions (Rb+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:49847, GOC:yaf]
EOG8BS00N	GO:0006813	1/215	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8NW20D	GO:0005524	9/61	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8NW20D	GO:0004713	6/61	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8NW20D	GO:0004715	2/61	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8NW20D	GO:0004672	1/61	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG87H848	GO:0005351	1/4	sugar:proton symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]
EOG87H848	GO:0016491	1/4	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG87H848	GO:0008270	1/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87H848	GO:0008982	1/4	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	molecular_function	"Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-]
EOG87H848	GO:0015577	1/4	galactitol transmembrane transporter activity	molecular_function	"Enables the transfer of a galactitol from one side of the membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG87H848	GO:0009401	1/4	phosphoenolpyruvate-dependent sugar phosphotransferase system	biological_process	"The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html]
EOG87H848	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DBWW2	GO:0003676	1/11	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8P8J07	GO:0008270	2/94	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8P8J07	GO:0003676	2/94	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8F7QZS	GO:0007010	22/93	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG89W4WM	GO:0008157	1/112	protein phosphatase 1 binding	molecular_function	"Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl]
EOG8VMHW7	GO:0003964	1/62	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8VMHW7	GO:0003723	1/62	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG805VDX	GO:0007416	4/190	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG805VDX	GO:0007269	3/190	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG805VDX	GO:0051965	3/190	positive regulation of synapse assembly	biological_process	"Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
EOG805VDX	GO:0090129	3/190	positive regulation of synapse maturation	biological_process	"Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG805VDX	GO:0050808	1/190	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG805VDX	GO:0034185	1/190	apolipoprotein binding	molecular_function	"Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex." [GOC:BHF, GOC:rl]
EOG805VDX	GO:0051124	1/190	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG805VDX	GO:2000331	1/190	regulation of terminal button organization	biological_process	"Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah]
EOG805VDX	GO:1900073	1/190	regulation of neuromuscular synaptic transmission	biological_process	"Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
EOG805VDX	GO:0005515	1/190	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG805VDX	GO:0008306	1/190	associative learning	biological_process	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
EOG805VDX	GO:0071938	1/190	vitamin A transport	biological_process	"The directed movement any form of vitamin A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]
EOG805VDX	GO:0007274	1/190	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG805VDX	GO:0097109	1/190	neuroligin family protein binding	molecular_function	"Interacting selectively and non-covalently with a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation." [GOC:BHF, GOC:pr, GOC:sjp, PMID:21424692]
EOG805VDX	GO:1900244	1/190	positive regulation of synaptic vesicle endocytosis	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie]
EOG805VDX	GO:0005886	1/190	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG805VDX	GO:0031594	1/190	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG805VDX	GO:0007268	1/190	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG805VDX	GO:0040012	1/190	regulation of locomotion	biological_process	"Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems]
EOG8ZKN3G	GO:0008270	4/129	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZKN3G	GO:0003964	2/129	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8ZKN3G	GO:0003676	2/129	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZKN3G	GO:0003723	2/129	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8ZKN3G	GO:0015074	1/129	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG805VDW	GO:0016020	82/211	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG805VDW	GO:0005215	82/211	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG805VDW	GO:0031427	1/211	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG80306V	GO:0008270	329/890	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80306V	GO:0004181	329/890	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG80306V	GO:0005319	8/890	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG80306V	GO:0005615	3/890	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG80306V	GO:0007586	1/890	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG80306V	GO:0022008	1/890	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG80306V	GO:0031982	1/890	vesicle	cellular_component	"Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz]
EOG80306V	GO:0004180	1/890	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG80306V	GO:0005515	1/890	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG80306V	GO:0005576	1/890	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG80306V	GO:0016021	1/890	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80306V	GO:0004930	1/890	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8MKQW2	GO:0003676	3/252	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MKQW2	GO:0000166	3/252	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8MKQW2	GO:0003677	2/252	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8MKQW2	GO:0006360	1/252	transcription from RNA polymerase I promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
EOG8MKQW2	GO:0042302	1/252	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8MKQW2	GO:0005201	1/252	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG8MKQW2	GO:0031012	1/252	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8MKQW2	GO:0000226	1/252	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8MKQW2	GO:0007304	1/252	chorion-containing eggshell formation	biological_process	"The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8MKQW2	GO:0016787	1/252	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8MKQW2	GO:0022008	1/252	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8MKQW2	GO:0005736	1/252	DNA-directed RNA polymerase I complex	cellular_component	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8MKQW2	GO:0042600	1/252	chorion	cellular_component	"A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
EOG8MKQW2	GO:0005874	1/252	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8XSP3R	GO:0046872	13/72	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XSP3R	GO:0003824	12/72	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8XSP3R	GO:0016020	1/72	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XSP3R	GO:0008236	1/72	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8PG8HR	GO:0003964	4/50	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8PG8HR	GO:0003723	3/50	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8PG8HR	GO:0004519	1/50	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8PG8HR	GO:0008270	1/50	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XSP3N	GO:0008061	250/966	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8XSP3N	GO:0005576	250/966	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8XSP3N	GO:0006030	246/966	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8XSP3N	GO:0004252	27/966	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8XSP3N	GO:0005044	26/966	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8XSP3N	GO:0016020	24/966	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XSP3N	GO:0006032	4/966	chitin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8XSP3N	GO:0005975	4/966	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8XSP3N	GO:0004568	4/966	chitinase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
EOG8XSP3N	GO:0006955	2/966	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8XSP3N	GO:0030247	2/966	polysaccharide binding	molecular_function	"Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah]
EOG8XSP3N	GO:0030246	2/966	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8XSP3N	GO:0006508	1/966	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8XSP3N	GO:0007616	1/966	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8XSP3N	GO:0004190	1/966	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8XSP3N	GO:0007614	1/966	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8D296V	GO:0005634	6/48	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZSCM0	GO:0005634	22/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZSCM0	GO:0030915	22/88	Smc5-Smc6 complex	cellular_component	"A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739]
EOG8ZSCM0	GO:0006281	22/88	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8PG8HC	GO:0046872	4/16	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8PG8HC	GO:0003676	3/16	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZSCM4	GO:0003677	1/17	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84QWDR	GO:0007615	1/103	anesthesia-resistant memory	biological_process	"The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531]
EOG84QWDR	GO:0048789	1/103	cytoskeletal matrix organization at active zone	biological_process	"The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane." [GOC:dh, GOC:ef, GOC:jid, PMID:12812759]
EOG84QWDR	GO:0008344	1/103	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG84QWDR	GO:0007274	1/103	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG84QWDR	GO:0048790	1/103	maintenance of presynaptic active zone structure	biological_process	"The process in which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr]
EOG84QWDR	GO:0007614	1/103	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG84QWDR	GO:0007268	1/103	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG84QWDR	GO:0031594	1/103	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG84QWDR	GO:0048786	1/103	presynaptic active zone	cellular_component	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
EOG84QWDR	GO:0007269	1/103	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG84QWDR	GO:0048167	1/103	regulation of synaptic plasticity	biological_process	"A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290]
EOG84QWDR	GO:0032440	1/103	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG84QWDR	GO:0048788	1/103	cytoskeleton of presynaptic active zone	cellular_component	"The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, NIF_Subcellular:sao1470121605, PMID:10944438]
EOG81G5J5	GO:0005524	24/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG81G5J5	GO:0004672	23/91	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG81G5J5	GO:0016772	1/91	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8VT8BB	GO:0005509	16/83	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8VT8BB	GO:0016301	3/83	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8VT8BB	GO:0007596	1/83	blood coagulation	biological_process	"The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [http://www.graylab.ac.uk/omd/, ISBN:0198506732]
EOG8VT8BB	GO:0004888	1/83	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8VT8BB	GO:0016787	1/83	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8VT8BB	GO:0016020	1/83	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG84QWDW	GO:0008270	6/47	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84QWDW	GO:0005622	6/47	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG84QWDT	GO:0006468	1/97	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG84QWDT	GO:0007476	1/97	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG84QWDT	GO:0005576	1/97	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG84QWDT	GO:0004672	1/97	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG84QWDT	GO:0005794	1/97	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG84QWDX	GO:0035317	1/95	imaginal disc-derived wing hair organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853]
EOG84QWDX	GO:0005938	1/95	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG84QWDX	GO:0035017	1/95	cuticle pattern formation	biological_process	"The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf]
EOG84QWDX	GO:0048800	1/95	antennal morphogenesis	biological_process	"The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid]
EOG84QWDX	GO:0009913	1/95	epidermal cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]
EOG8WQ3JK	GO:0016021	22/110	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WQ3JK	GO:0004930	22/110	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8WQ3JK	GO:0016491	4/110	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8WQ3JK	GO:0007186	1/110	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8VT8BK	GO:0016226	1/4	iron-sulfur cluster assembly	biological_process	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]
EOG8NZX8B	GO:0016021	3/176	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NZX8B	GO:0006506	2/176	GPI anchor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
EOG8NZX8B	GO:0000139	2/176	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8NZX8B	GO:0015031	2/176	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8NZX8B	GO:0005789	2/176	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8NZX8B	GO:0008565	2/176	protein transporter activity	molecular_function	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
EOG8Q87BB	GO:0003677	23/90	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Q87BB	GO:0004519	15/90	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8Q87BB	GO:0006281	14/90	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8Q87BB	GO:0006259	9/90	DNA metabolic process	biological_process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]
EOG8Q87BB	GO:0004518	8/90	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8Q87BB	GO:0000737	1/90	DNA catabolic process, endonucleolytic	biological_process	"The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
EOG8Q87BB	GO:0000724	1/90	double-strand break repair via homologous recombination	biological_process	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]
EOG8Q87BB	GO:0006974	1/90	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8Q87BB	GO:0003697	1/90	single-stranded DNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174]
EOG8Q87BB	GO:1901255	1/90	nucleotide-excision repair involved in interstrand cross-link repair	biological_process	"Any nucleotide-excision repair that is involved in interstrand cross-link repair." [GOC:TermGenie, PMID:22064477]
EOG8Q87BB	GO:0007131	1/90	reciprocal meiotic recombination	biological_process	"The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]
EOG8Q87BB	GO:0000110	1/90	nucleotide-excision repair factor 1 complex	cellular_component	"One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively." [PMID:10915862]
EOG8Q87BB	GO:0016321	1/90	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8Q87BB	GO:0000712	1/90	resolution of meiotic recombination intermediates	biological_process	"The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]
EOG8Q87BB	GO:0003684	1/90	damaged DNA binding	molecular_function	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
EOG8Q87BB	GO:0006289	1/90	nucleotide-excision repair	biological_process	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]
EOG8Q87BB	GO:0007095	1/90	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8Q87BB	GO:0006310	1/90	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8Q87BB	GO:0007143	1/90	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8Q87BB	GO:0006296	1/90	nucleotide-excision repair, DNA incision, 5'-to lesion	biological_process	"The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage." [GOC:elh, PMID:10197977]
EOG8Q87BB	GO:0046982	1/90	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8Q87BB	GO:0006298	1/90	mismatch repair	biological_process	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
EOG8Q87BB	GO:0006302	1/90	double-strand break repair	biological_process	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]
EOG8Q87BB	GO:0000014	1/90	single-stranded DNA endodeoxyribonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah]
EOG8Q87BB	GO:0043234	1/90	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8Q87BB	GO:0045132	1/90	meiotic chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah]
EOG8Q87BB	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VT8BS	GO:0030239	1/120	myofibril assembly	biological_process	"Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]
EOG8VT8BS	GO:0008157	1/120	protein phosphatase 1 binding	molecular_function	"Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl]
EOG8VT8BS	GO:0007498	1/120	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8VT8BS	GO:0051371	1/120	muscle alpha-actinin binding	molecular_function	"Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc." [PMID:10984498, PMID:11699871, PMID:15014165]
EOG8VT8BS	GO:0030018	1/120	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8VT8BQ	GO:0050662	23/81	coenzyme binding	molecular_function	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
EOG8VT8BQ	GO:0044237	23/81	cellular metabolic process	biological_process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
EOG8VT8BQ	GO:0003824	22/81	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8VT8BQ	GO:0003978	1/81	UDP-glucose 4-epimerase activity	molecular_function	"Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2]
EOG8C8B7H	GO:0008270	55/132	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8C8B7H	GO:0016874	2/132	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8J6V4Q	GO:0005615	1/94	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8J6V4Q	GO:0032504	1/94	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8D81MD	GO:0046872	26/86	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8D81MD	GO:0003824	21/86	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8D81MD	GO:0004222	3/86	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8D81MD	GO:0016787	1/86	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8D81MD	GO:0008121	1/86	ubiquinol-cytochrome-c reductase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]
EOG8D81MD	GO:0005811	1/86	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8D81MD	GO:0005739	1/86	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8D81MD	GO:0005875	1/86	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8KH5B7	GO:0022008	1/89	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8VT8B7	GO:0016021	27/94	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VT8B7	GO:0008270	4/94	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VT8B7	GO:0035045	1/94	sperm plasma membrane disassembly	biological_process	"The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg." [GOC:bf, ISBN:0879694238]
EOG8VT8B7	GO:0001669	1/94	acrosomal vesicle	cellular_component	"A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732]
EOG8VT8B7	GO:0035042	1/94	fertilization, exchange of chromosomal proteins	biological_process	"Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity." [GOC:bf, PMID:11735001]
EOG8VT8B7	GO:0035041	1/94	sperm chromatin decondensation	biological_process	"Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus." [GOC:bf, PMID:11735001]
EOG8VT8B4	GO:0035556	17/105	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8VT8B4	GO:0008237	1/105	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8VT8B5	GO:0030424	3/282	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8VT8B5	GO:0007411	3/282	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8VT8B5	GO:0008406	3/282	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG8VT8B5	GO:0022409	2/282	positive regulation of cell-cell adhesion	biological_process	"Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
EOG8VT8B5	GO:0016319	2/282	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8VT8B5	GO:2000274	2/282	regulation of epithelial cell migration, open tracheal system	biological_process	"Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system." [GOC:obol]
EOG8VT8B5	GO:0003151	2/282	outflow tract morphogenesis	biological_process	"The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145]
EOG8VT8B5	GO:0048036	2/282	central complex development	biological_process	"The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252]
EOG8VT8B5	GO:0035050	2/282	embryonic heart tube development	biological_process	"The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
EOG8VT8B5	GO:0004872	2/282	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8VT8B5	GO:0008038	2/282	neuron recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators]
EOG8VT8B5	GO:0007419	2/282	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8VT8B5	GO:0007432	2/282	salivary gland boundary specification	biological_process	"Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957]
EOG8VT8B5	GO:0005886	1/282	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8VT8B5	GO:0031987	1/282	locomotion involved in locomotory behavior	biological_process	"Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
EOG8VT8B5	GO:0048854	1/282	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG8VT8B5	GO:0009649	1/282	entrainment of circadian clock	biological_process	"The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid]
EOG8VT8B5	GO:0001764	1/282	neuron migration	biological_process	"The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]
EOG8VT8B5	GO:0007427	1/282	epithelial cell migration, open tracheal system	biological_process	"The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8VT8B5	GO:0043025	1/282	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8VT8B5	GO:0005887	1/282	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VT8B5	GO:0005515	1/282	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VT8B5	GO:0035385	1/282	Roundabout signaling pathway	biological_process	"A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling]
EOG8VT8B5	GO:0044295	1/282	axonal growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954]
EOG8VT8B5	GO:0016199	1/282	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG8VT8B5	GO:0030425	1/282	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8VT8B5	GO:0001964	1/282	startle response	biological_process	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
EOG8VT8B5	GO:0046716	1/282	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG8VT8B5	GO:0042685	1/282	cardioblast cell fate specification	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG8VT8B5	GO:0071666	1/282	Slit-Robo signaling complex	cellular_component	"A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate." [GOC:sart, PMID:17062560, PMID:18359766]
EOG8VT8B5	GO:0072499	1/282	photoreceptor cell axon guidance	biological_process	"The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
EOG8VT8B5	GO:0042803	1/282	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8VT8B5	GO:0031982	1/282	vesicle	cellular_component	"Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz]
EOG8VT8B5	GO:0007426	1/282	tracheal outgrowth, open tracheal system	biological_process	"The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8VT8B5	GO:0008201	1/282	heparin binding	molecular_function	"Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]
EOG8VT8B5	GO:0048813	1/282	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8VT8B5	GO:0008039	1/282	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8VT8B5	GO:0043234	1/282	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8VT8B5	GO:0070983	1/282	dendrite guidance	biological_process	"The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
EOG8VT8B5	GO:0050773	1/282	regulation of dendrite development	biological_process	"Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai]
EOG8VT8B5	GO:0008045	1/282	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8J6V4N	GO:0005524	24/107	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8J6V4N	GO:0004674	19/107	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8J6V4N	GO:0004672	4/107	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8J6V4N	GO:0004709	2/107	MAP kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
EOG8J6V4N	GO:0016772	1/107	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8J6V4N	GO:0016740	1/107	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8J6V4N	GO:0016301	1/107	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8WHC5B	GO:0003723	1/3	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8WHC5B	GO:0003676	1/3	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WHC5B	GO:0003964	1/3	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8WHC5B	GO:0008270	1/3	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VT8B8	GO:0046872	2/95	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8VT8B8	GO:0003677	1/95	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8VT8B8	GO:0006351	1/95	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8VT8B8	GO:0048666	1/95	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8VT8B8	GO:2001229	1/95	negative regulation of response to gamma radiation	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation." [GOC:obol]
EOG8VT8B8	GO:0003747	1/95	translation release factor activity	molecular_function	"Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]
EOG8VT8B8	GO:0042054	1/95	histone methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue." [EC:2.1.1.43]
EOG8VT8B8	GO:0000790	1/95	nuclear chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130]
EOG8VT8B8	GO:0016571	1/95	histone methylation	biological_process	"The modification of histones by addition of methyl groups." [GOC:ai]
EOG8VT8B8	GO:0022008	1/95	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8VT8B8	GO:0035097	1/95	histone methyltransferase complex	cellular_component	"A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf]
EOG8VT8B8	GO:0005515	1/95	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VT8B8	GO:0048813	1/95	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8VT8B8	GO:0045892	1/95	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8VT8B8	GO:0005634	1/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VT8B8	GO:0070734	1/95	histone H3-K27 methylation	biological_process	"The modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:mah]
EOG8VT8B8	GO:0016458	1/95	gene silencing	biological_process	"Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb]
EOG8VT8B8	GO:0035098	1/95	ESC/E(Z) complex	cellular_component	"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]
EOG8VT8B8	GO:0007517	1/95	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8VT8B9	GO:0016021	63/217	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VT8B9	GO:0004930	44/217	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8VT8B9	GO:0001607	19/217	neuromedin U receptor activity	molecular_function	"Combining with neuromedin U to initiate a change in cell activity." [GOC:ai]
EOG8VT8B9	GO:0036401	3/217	pyrokinin receptor activity	molecular_function	"Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation." [GOC:ha, PMID:12951076, PMID:19186060]
EOG8VT8B9	GO:0050254	3/217	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8VT8B9	GO:0007218	3/217	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8VT8B9	GO:0005887	3/217	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VT8B9	GO:0007186	3/217	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8VT8B9	GO:0008188	3/217	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8VT8B9	GO:0001653	1/217	peptide receptor activity	molecular_function	"Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl]
EOG8VX4MD	GO:0003676	1/163	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80KBHP	GO:0005524	2/6	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8D2962	GO:0003964	185/1227	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8D2962	GO:0003723	151/1227	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8D2962	GO:0004519	49/1227	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8D2962	GO:0006355	11/1227	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8D2962	GO:0003676	2/1227	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8D2962	GO:0003677	2/1227	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8D2962	GO:0008270	1/1227	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D2962	GO:0046872	1/1227	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8D2962	GO:0008234	1/1227	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8D2962	GO:0050660	1/1227	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8D2962	GO:0016021	1/1227	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D2962	GO:0008033	1/1227	tRNA processing	biological_process	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]
EOG8D2962	GO:0005634	1/1227	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D2962	GO:0022857	1/1227	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8D2968	GO:0003677	56/1616	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8D2968	GO:0006313	36/1616	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG8D2968	GO:0015074	36/1616	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8D2968	GO:0004803	36/1616	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG8D2968	GO:0006355	9/1616	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8D2968	GO:0008270	4/1616	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D2968	GO:0007275	3/1616	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8D2968	GO:0005634	3/1616	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D2968	GO:0006351	3/1616	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8NKF8C	GO:0016021	5/107	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NKF8C	GO:0046872	2/107	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NKF8C	GO:0000166	2/107	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8NKF8B	GO:0005319	30/134	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG8NKF8B	GO:0005576	1/134	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8NKF8B	GO:0006629	1/134	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8NKF8B	GO:0015918	1/134	sterol transport	biological_process	"The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]
EOG8NKF8B	GO:0005875	1/134	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8NKF8B	GO:0034196	1/134	acylglycerol transport	biological_process	"The directed movement of an acylglycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:BHF, GOC:rl]
EOG8NKF8B	GO:0003700	1/134	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NKF8B	GO:0045178	1/134	basal part of cell	cellular_component	"The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194]
EOG8NKF8B	GO:0043565	1/134	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NKF8B	GO:0004806	1/134	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG8NKF8B	GO:0005615	1/134	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8J13NV	GO:0016021	51/183	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J13NV	GO:0005509	49/183	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8J13NV	GO:0004714	1/183	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8J13NV	GO:0016787	1/183	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8J13NV	GO:0040003	1/183	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8J13NV	GO:0016324	1/183	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8J13NV	GO:0030100	1/183	regulation of endocytosis	biological_process	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]
EOG8J13NV	GO:0005044	1/183	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8J13NV	GO:0048082	1/183	regulation of adult chitin-containing cuticle pigmentation	biological_process	"Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
EOG8FFGFZ	GO:0005509	20/63	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8B8MWT	GO:0008270	25/101	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8B8MWT	GO:0004402	24/101	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8B8MWT	GO:0006355	23/101	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8B8MWT	GO:0003713	20/101	transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8B8MWT	GO:0005634	18/101	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8B8MWT	GO:0000123	6/101	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG8B8MWT	GO:0003712	5/101	transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8B8MWT	GO:0008140	1/101	cAMP response element binding protein binding	molecular_function	"Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein)." [GOC:mah]
EOG8B8MWT	GO:0040040	1/101	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG8B8MWT	GO:0007088	1/101	regulation of mitotic nuclear division	biological_process	"Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
EOG8B8MWT	GO:0043982	1/101	histone H4-K8 acetylation	biological_process	"The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone." [GOC:jl]
EOG8B8MWT	GO:0016592	1/101	mediator complex	cellular_component	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
EOG8B8MWT	GO:0016849	1/101	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG8B8MWT	GO:0043993	1/101	histone acetyltransferase activity (H3-K18 specific)	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)." [EC:2.3.1.48]
EOG8B8MWT	GO:0001745	1/101	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8B8MWT	GO:0016021	1/101	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8B8MWT	GO:0008134	1/101	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8B8MWT	GO:0043983	1/101	histone H4-K12 acetylation	biological_process	"The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl]
EOG8B8MWT	GO:0043234	1/101	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8B8MWT	GO:0016055	1/101	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG8B8MWT	GO:0045475	1/101	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8B8MWT	GO:0032922	1/101	circadian regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah]
EOG8B8MWT	GO:0035556	1/101	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8B8MWT	GO:0007224	1/101	smoothened signaling pathway	biological_process	"A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
EOG8B8MWT	GO:0007416	1/101	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG8B8MWT	GO:0001104	1/101	RNA polymerase II transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8B8MWT	GO:0043974	1/101	histone H3-K27 acetylation	biological_process	"The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone." [GOC:jl]
EOG8B8MWT	GO:0007269	1/101	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8B8MWT	GO:0045466	1/101	R7 cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339]
EOG8B8MWT	GO:0022008	1/101	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8B8MWT	GO:0045944	1/101	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8B8MWT	GO:0000076	1/101	DNA replication checkpoint	biological_process	"A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518]
EOG8B8MWT	GO:0005515	1/101	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8B8MWT	GO:0043971	1/101	histone H3-K18 acetylation	biological_process	"The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone." [GOC:jl]
EOG8B8MWT	GO:0009190	1/101	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG8B8MWT	GO:0000166	1/101	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8B8MWT	GO:0048749	1/101	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8B8MWT	GO:0030097	1/101	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG8B8MWT	GO:0007464	1/101	R3/R4 cell fate commitment	biological_process	"The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
EOG8B8MWT	GO:0044017	1/101	histone acetyltransferase activity (H3-K27 specific)	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27)." [EC:2.3.1.48]
EOG8B8MWT	GO:0008347	1/101	glial cell migration	biological_process	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
EOG88972Q	GO:0016021	3/95	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NKF8T	GO:0046872	4/104	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NKF8T	GO:0008270	3/104	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NKF8T	GO:0003676	3/104	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NKF8T	GO:0005634	1/104	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NKF8T	GO:0032797	1/104	SMN complex	cellular_component	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]
EOG8NKF8Q	GO:0004571	26/86	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113]
EOG8NKF8Q	GO:0016020	26/86	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NKF8Q	GO:0005509	26/86	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8NKF8Q	GO:0030968	1/86	endoplasmic reticulum unfolded protein response	biological_process	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]
EOG8NKF8Q	GO:0030433	1/86	ER-associated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]
EOG8NKF8Q	GO:0008340	1/86	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG88972Z	GO:0003682	1/27	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG803071	GO:0005634	1/36	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG803071	GO:0003676	1/36	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG803071	GO:0008270	1/36	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8QJV2D	GO:0009253	22/121	peptidoglycan catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
EOG8QJV2D	GO:0008745	22/121	N-acetylmuramoyl-L-alanine amidase activity	molecular_function	"Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]
EOG8QJV2D	GO:0046872	1/121	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG86MF1B	GO:0005811	1/74	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8W9MJ9	GO:0046872	20/84	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8W9MJ9	GO:0005634	3/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8W9MJ9	GO:0003676	2/84	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W9MJ9	GO:0044719	1/84	regulation of imaginal disc-derived wing size	biological_process	"Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
EOG8W9MJ9	GO:0016203	1/84	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8W9MJ9	GO:0003677	1/84	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8W9MJ9	GO:0006351	1/84	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8W9MJ9	GO:0007423	1/84	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8W9MJ9	GO:0048666	1/84	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8W9MJ9	GO:0007298	1/84	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8W9MJ9	GO:0006355	1/84	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8W9MJ9	GO:0007517	1/84	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8W9MJ9	GO:0016198	1/84	axon choice point recognition	biological_process	"The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152]
EOG8W9MJ9	GO:0048813	1/84	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8W9MJ9	GO:0016319	1/84	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8W9MJ9	GO:0003700	1/84	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8W9MJ9	GO:0008039	1/84	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8323CW	GO:0016620	1/6	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG82VBW4	GO:0051536	28/106	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG82VBW4	GO:0006222	26/106	UMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732]
EOG82VBW4	GO:0004158	22/106	dihydroorotate oxidase activity	molecular_function	"Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate." [EC:1.3.3.1, RHEA:15444]
EOG82VBW4	GO:0005737	22/106	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82VBW4	GO:0006207	16/106	'de novo' pyrimidine nucleobase biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]
EOG82VBW4	GO:0004152	4/106	dihydroorotate dehydrogenase activity	molecular_function	"Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate." [EC:1.3.5.2, RHEA:18076]
EOG82VBW4	GO:0017113	2/106	dihydropyrimidine dehydrogenase (NADP+) activity	molecular_function	"Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+." [EC:1.3.1.2]
EOG82VBW4	GO:0052888	1/106	obsolete OBSOLETE:dihydroorotate oxidase (fumarate) activity	molecular_function	"Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate." [EC:1.3.98.1, RHEA:30062]
EOG82VBW4	GO:0003824	1/106	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG82VBW7	GO:0016301	1/15	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG82VBW6	GO:0007165	17/86	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG82VBW6	GO:0005622	16/86	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG82VBW6	GO:0046856	14/86	phosphatidylinositol dephosphorylation	biological_process	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]
EOG82VBW6	GO:0031011	1/86	Ino80 complex	cellular_component	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820]
EOG82VBW6	GO:0004445	1/86	inositol-polyphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56]
EOG82VBW6	GO:0032187	1/86	actomyosin contractile ring localization	biological_process	"The process in which a contractile ring is assembled and/or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:mah]
EOG82VBW6	GO:0006897	1/86	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG82VBW6	GO:0004439	1/86	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36, RHEA:22767]
EOG82VBW6	GO:0055037	1/86	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG82VBW6	GO:2000431	1/86	regulation of cytokinesis, actomyosin contractile ring assembly	biological_process	"Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol]
EOG82VBW6	GO:0034593	1/86	phosphatidylinositol bisphosphate phosphatase activity	molecular_function	"Catalysis of the reaction: phosphatidylinositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate." [GOC:mah]
EOG82VBW6	GO:0052659	1/86	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56, RHEA:11395]
EOG82VBW6	GO:0005770	1/86	late endosome	cellular_component	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
EOG82VBW6	GO:0052658	1/86	inositol-1,4,5-trisphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate." [EC:3.1.3.56, RHEA:19800]
EOG82VBW6	GO:0005769	1/86	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG82VBW6	GO:0005737	1/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8MGVN3	GO:0006898	1/103	receptor-mediated endocytosis	biological_process	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
EOG8MGVN3	GO:0007298	1/103	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8MGVN3	GO:0005875	1/103	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8CJXZ7	GO:0005615	3/125	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8CJXZ7	GO:0042595	1/125	behavioral response to starvation	biological_process	"Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators]
EOG8CJXZ7	GO:0007623	1/125	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG8CJXZ7	GO:0008343	1/125	adult feeding behavior	biological_process	"Feeding behavior in a fully developed and mature organism." [GOC:mah]
EOG8CJXZ7	GO:0007622	1/125	rhythmic behavior	biological_process	"The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr]
EOG8CJXZ7	GO:0007631	1/125	feeding behavior	biological_process	"Behavior associated with the intake of food." [GOC:mah]
EOG8CJXZ7	GO:0007617	1/125	mating behavior	biological_process	"The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph]
EOG8CJXZ7	GO:0005576	1/125	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8CJXZ7	GO:0042594	1/125	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8CJXZ7	GO:0008049	1/125	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8CJXZ6	GO:0015937	6/89	coenzyme A biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
EOG8CJXZ6	GO:0005524	6/89	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CJXZ6	GO:0004594	6/89	pantothenate kinase activity	molecular_function	"Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33]
EOG8CJXZ6	GO:0016301	1/89	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8MGVN7	GO:0031248	1/92	protein acetyltransferase complex	cellular_component	"A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf]
EOG8MGVN7	GO:0004596	1/92	peptide alpha-N-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [EC:2.3.1.88, GOC:mah]
EOG8MGVN7	GO:0072686	1/92	mitotic spindle	cellular_component	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
EOG8MGVN7	GO:0022008	1/92	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8MGVN7	GO:0016740	1/92	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8MGVN4	GO:0046872	1/41	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG854CD2	GO:0016021	27/75	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG854CD2	GO:0016500	27/75	protein-hormone receptor activity	molecular_function	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]
EOG854CD2	GO:0004930	1/75	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG854CD2	GO:0042562	1/75	hormone binding	molecular_function	"Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
EOG854CD2	GO:0005840	1/75	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG854CD2	GO:0008188	1/75	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG854CD2	GO:0007186	1/75	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG854CD2	GO:0007218	1/75	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG854CD2	GO:0005887	1/75	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG854CD2	GO:0004715	1/75	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG854CD2	GO:0009755	1/75	hormone-mediated signaling pathway	biological_process	"A series of molecular signals mediated by the detection of a hormone." [GOC:sm]
EOG86MF1X	GO:0034453	6/42	microtubule anchoring	biological_process	"Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah]
EOG86MF1X	GO:0005815	6/42	microtubule organizing center	cellular_component	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416]
EOG8CJXZG	GO:0003899	2/211	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8CJXZG	GO:0003677	2/211	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CJXZG	GO:0006351	2/211	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8CJXZG	GO:0003676	1/211	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MGVNF	GO:0003676	5/132	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MGVNF	GO:0008270	5/132	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MGVNF	GO:0003723	2/132	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8MGVNF	GO:0003964	2/132	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8MGVNF	GO:0003677	2/132	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8MGVNF	GO:0015074	2/132	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8MGVNF	GO:0045202	1/132	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8MGVNF	GO:0003012	1/132	muscle system process	biological_process	"A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio]
EOG8MGVNF	GO:0042595	1/132	behavioral response to starvation	biological_process	"Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators]
EOG8MGVNF	GO:0030017	1/132	sarcomere	cellular_component	"The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]
EOG82VBWZ	GO:0003993	33/135	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG82VBWZ	GO:0052826	1/135	inositol hexakisphosphate 2-phosphatase activity	molecular_function	"Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.62]
EOG8F4VQZ	GO:0006265	37/111	DNA topological change	biological_process	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]
EOG8F4VQZ	GO:0003918	37/111	DNA topoisomerase type II (ATP-hydrolyzing) activity	molecular_function	"Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192]
EOG8F4VQZ	GO:0003677	37/111	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8F4VQZ	GO:0005524	37/111	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8F4VQZ	GO:0016491	2/111	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8F4VQZ	GO:0000400	1/111	four-way junction DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464]
EOG8F4VQZ	GO:0003729	1/111	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8F4VQZ	GO:0046872	1/111	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8F4VQZ	GO:0006200	1/111	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8F4VQZ	GO:0000712	1/111	resolution of meiotic recombination intermediates	biological_process	"The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]
EOG8F4VQZ	GO:0008623	1/111	CHRAC	cellular_component	"An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179, PMID:9252192]
EOG8F4VQZ	GO:0007052	1/111	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8F4VQZ	GO:0007126	1/111	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8F4VQZ	GO:0006312	1/111	mitotic recombination	biological_process	"The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles." [GOC:elh]
EOG8F4VQZ	GO:0007095	1/111	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8F4VQZ	GO:0000819	1/111	sister chromatid segregation	biological_process	"The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh]
EOG8F4VQZ	GO:0007076	1/111	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8F4VQZ	GO:0005694	1/111	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8F4VQZ	GO:0007067	1/111	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8F4VQZ	GO:0004252	1/111	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8F4VQZ	GO:0006261	1/111	DNA-dependent DNA replication	biological_process	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]
EOG8F4VQZ	GO:0000795	1/111	synaptonemal complex	cellular_component	"A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh]
EOG8F4VQZ	GO:0051310	1/111	metaphase plate congression	biological_process	"The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ai]
EOG8F4VQZ	GO:0003696	1/111	satellite DNA binding	molecular_function	"Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005]
EOG8F4VQZ	GO:0000182	1/111	rDNA binding	molecular_function	"Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA." [GOC:mah]
EOG8F4VQZ	GO:0005634	1/111	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8F4VQZ	GO:0006342	1/111	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG86MF17	GO:0046872	3/84	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8MGVNP	GO:0030131	25/92	clathrin adaptor complex	cellular_component	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]
EOG8MGVNP	GO:0006886	25/92	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8MGVNP	GO:0016192	24/92	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8MGVNP	GO:0016183	1/92	synaptic vesicle coating	biological_process	"A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:curators, PMID:10099709]
EOG8MGVNP	GO:0006887	1/92	exocytosis	biological_process	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
EOG8MGVNP	GO:0006727	1/92	ommochrome biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
EOG8MGVNP	GO:0030135	1/92	coated vesicle	cellular_component	"Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]
EOG8MGVNP	GO:0008340	1/92	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8MGVNP	GO:0006897	1/92	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8MGVNP	GO:0007040	1/92	lysosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]
EOG8MGVNP	GO:0022008	1/92	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8MGVNP	GO:0007220	1/92	Notch receptor processing	biological_process	"The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]
EOG8MGVNP	GO:0008021	1/92	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8MGVNP	GO:0007269	1/92	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8MGVNP	GO:0046907	1/92	intracellular transport	biological_process	"The directed movement of substances within a cell." [GOC:ai]
EOG8MGVNP	GO:0006901	1/92	vesicle coating	biological_process	"A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid]
EOG86MF15	GO:0005840	19/85	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG86MF15	GO:0003735	19/85	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG86MF15	GO:0006412	18/85	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG86MF15	GO:0003723	18/85	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG86MF15	GO:0005762	1/85	mitochondrial large ribosomal subunit	cellular_component	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
EOG8CJXZR	GO:0016021	21/53	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CJXZR	GO:0004930	20/53	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8CJXZR	GO:0005887	1/53	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CJXZR	GO:0007218	1/53	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8CJXZR	GO:0035236	1/53	proctolin receptor activity	molecular_function	"Combining with the neuropeptide proctolin, to initiate a change in cell activity." [GOC:bf]
EOG8CJXZR	GO:0008188	1/53	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8CJXZR	GO:0007186	1/53	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8MGVNX	GO:0008455	37/112	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R." [EC:2.4.1.143]
EOG8MGVNX	GO:0016021	37/112	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8MGVNX	GO:0009312	37/112	oligosaccharide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]
EOG8MGVNX	GO:0005795	36/112	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG8MGVNX	GO:0006487	1/112	protein N-linked glycosylation	biological_process	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]
EOG8MGVNX	GO:0005797	1/112	Golgi medial cisterna	cellular_component	"The middle Golgi cisterna (or cisternae)." [ISBN:0815316194]
EOG8MGVNX	GO:0008375	1/112	acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]
EOG82VBWF	GO:0005681	1/115	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG82VBWF	GO:0000398	1/115	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG82VBWC	GO:0005576	1/29	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG82VBWC	GO:0008061	1/29	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG82VBWC	GO:0006030	1/29	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG86MF19	GO:0000387	24/85	spliceosomal snRNP assembly	biological_process	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG86MF19	GO:0005829	1/85	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG86MF19	GO:0005634	1/85	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86MF19	GO:0005856	1/85	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8RR8XC	GO:0005604	1/94	basement membrane	cellular_component	"A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]
EOG8RR8XC	GO:0016020	1/94	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RR8XC	GO:0007155	1/94	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8RR8XC	GO:0006914	1/94	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG8RR8XC	GO:0004871	1/94	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8P8HXZ	GO:0003899	27/98	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8P8HXZ	GO:0032549	27/98	ribonucleoside binding	molecular_function	"Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah]
EOG8P8HXZ	GO:0003677	27/98	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8P8HXZ	GO:0006351	26/98	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8P8HXZ	GO:0005634	22/98	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8P8HXZ	GO:0046872	1/98	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8P8HXZ	GO:0005736	1/98	DNA-directed RNA polymerase I complex	cellular_component	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8P8HXZ	GO:0022008	1/98	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8P8HXZ	GO:0006360	1/98	transcription from RNA polymerase I promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
EOG8RR8XH	GO:0042623	1/97	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8RR8XH	GO:0030286	1/97	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8RR8XH	GO:0008270	1/97	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RR8XH	GO:0007018	1/97	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8RR8XH	GO:0003676	1/97	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RR8XH	GO:0007605	1/97	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8RR8XH	GO:0006200	1/97	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8PRW6Z	GO:0016747	3/13	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8T1M1Q	GO:0003824	16/77	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8T1M1Q	GO:0004528	4/77	phosphodiesterase I activity	molecular_function	"Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [EC:3.1.4.1]
EOG8T1M1Q	GO:0046872	2/77	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8T1M1Q	GO:0003676	2/77	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8T1M1Q	GO:0035529	1/77	NADH pyrophosphatase activity	molecular_function	"Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+." [MetaCyc:RXN0-4401, PMID:12399474, PMID:20181750]
EOG8T1M1Q	GO:0016787	1/77	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8HB112	GO:0016021	34/136	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HB112	GO:0055085	34/136	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8HB112	GO:0005886	12/136	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8HB112	GO:0005215	12/136	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8HB110	GO:0046872	12/52	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HB110	GO:0003676	11/52	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HB110	GO:0001522	1/52	pseudouridine synthesis	biological_process	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]
EOG8HB110	GO:0009982	1/52	pseudouridine synthase activity	molecular_function	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]
EOG8HB110	GO:0003723	1/52	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8T1M3D	GO:0016021	24/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8T1M3D	GO:0005737	23/91	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8T1M3D	GO:0016627	23/91	oxidoreductase activity, acting on the CH-CH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8T1M3D	GO:0006629	23/91	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8T1M3D	GO:0005789	1/91	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8T1M3D	GO:0019348	1/91	dolichol metabolic process	biological_process	"The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732]
EOG8T1M3D	GO:0006486	1/91	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8T1M3D	GO:0006488	1/91	dolichol-linked oligosaccharide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309]
EOG8T1M3D	GO:0016095	1/91	polyprenol catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators, http://www.chem.qmul.ac.uk/iupac/misc/prenol.html#p2]
EOG8T1M3D	GO:0003865	1/91	3-oxo-5-alpha-steroid 4-dehydrogenase activity	molecular_function	"Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5]
EOG8FFGH0	GO:0005737	1/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8FFGH0	GO:0043130	1/86	ubiquitin binding	molecular_function	"Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]
EOG8FFGH0	GO:0005634	1/86	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FFGH0	GO:0045116	1/86	protein neddylation	biological_process	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]
EOG8FFGH3	GO:0006457	24/87	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8FFGH3	GO:0003755	24/87	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8QJV2V	GO:0008146	160/572	sulfotransferase activity	molecular_function	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]
EOG8QJV2V	GO:0004027	62/572	alcohol sulfotransferase activity	molecular_function	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2]
EOG8QJV2V	GO:0004304	10/572	estrone sulfotransferase activity	molecular_function	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4]
EOG8QJV2V	GO:0005829	3/572	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8QJV2V	GO:0051923	3/572	sulfation	biological_process	"The addition of a sulfate group to a molecule." [http://www.onelook.com]
EOG8QJV2V	GO:0006805	2/572	xenobiotic metabolic process	biological_process	"The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2]
EOG8QJV2V	GO:0004062	1/572	aryl sulfotransferase activity	molecular_function	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1]
EOG8FFGH6	GO:0007067	1/75	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8NCPSN	GO:0008026	28/90	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8NCPSN	GO:0005524	28/90	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8NCPSN	GO:0003676	26/90	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NCPSN	GO:0003682	2/90	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8NCPSN	GO:0001700	2/90	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8NCPSN	GO:0090305	2/90	nucleic acid phosphodiester bond hydrolysis	biological_process	"The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
EOG8NCPSN	GO:2001141	2/90	regulation of RNA biosynthetic process	biological_process	"Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph]
EOG8NCPSN	GO:0004527	2/90	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8NCPSN	GO:0005634	2/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NCPSN	GO:0032508	2/90	DNA duplex unwinding	biological_process	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]
EOG8NCPSN	GO:0033677	2/90	DNA/RNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA." [GOC:mah]
EOG8NCPSN	GO:0006302	2/90	double-strand break repair	biological_process	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]
EOG8NCPSN	GO:0008143	2/90	poly(A) binding	molecular_function	"Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl]
EOG8NCPSN	GO:0003712	2/90	transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8NCPSN	GO:0004518	2/90	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8NCPSN	GO:0006200	2/90	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8NCPSN	GO:0042254	1/90	ribosome biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
EOG8NCPSN	GO:0004386	1/90	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8QZB10	GO:0005549	4/130	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8QZB10	GO:0016021	4/130	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QZB10	GO:0004984	4/130	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8QZB10	GO:0004930	3/130	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8QZB10	GO:0016020	1/130	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QZB10	GO:0008527	1/130	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8QZB10	GO:0005886	1/130	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8NKFCJ	GO:0015074	4/97	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8NKFCJ	GO:0003676	4/97	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NKFCJ	GO:0003723	2/97	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8NKFCJ	GO:0008270	2/97	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NKFCJ	GO:0004190	2/97	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8NKFCJ	GO:0003964	2/97	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8QJV2Z	GO:0007606	16/1207	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8QJV2Z	GO:0005515	9/1207	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QJV2Z	GO:0016021	3/1207	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QJV2Z	GO:0008039	1/1207	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8QJV2Z	GO:0050914	1/1207	sensory perception of salty taste	biological_process	"The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8QJV2Z	GO:0002115	1/1207	store-operated calcium entry	biological_process	"A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991]
EOG8QJV2Z	GO:0035199	1/1207	salt aversion	biological_process	"The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf]
EOG8QJV2Z	GO:0048149	1/1207	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8QJV2Z	GO:0005886	1/1207	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG89PDDS	GO:0046872	23/80	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89PDDS	GO:0007275	1/80	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8KD93D	GO:0007111	1/82	meiosis II cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8KD93D	GO:0000915	1/82	actomyosin contractile ring assembly	biological_process	"The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
EOG8KD93D	GO:0007110	1/82	meiosis I cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8KD93D	GO:0005737	1/82	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8KD93D	GO:0032133	1/82	chromosome passenger complex	cellular_component	"A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910]
EOG8KD93D	GO:0046331	1/82	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8KD93D	GO:0043066	1/82	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8KD93D	GO:0007051	1/82	spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:mah]
EOG8KD93D	GO:0022008	1/82	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8KD93D	GO:0051225	1/82	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG8Z91B7	GO:0005887	1/100	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82RGR0	GO:0003676	1/8	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83BQ4D	GO:0008146	43/146	sulfotransferase activity	molecular_function	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]
EOG83BQ4D	GO:0008459	4/146	chondroitin 6-sulfotransferase activity	molecular_function	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17]
EOG83BQ4D	GO:0016740	1/146	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG841SVR	GO:0015074	1/70	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG841SVR	GO:0003676	1/70	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG866Z25	GO:0000813	1/85	ESCRT I complex	cellular_component	"An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
EOG866Z25	GO:0032509	1/85	endosome transport via multivesicular body sorting pathway	biological_process	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]
EOG8Z91BR	GO:0003700	85/407	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z91BR	GO:0005524	85/407	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8Z91BR	GO:0005634	85/407	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z91BR	GO:0003677	84/407	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Z91BR	GO:0006351	83/407	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8Z91BR	GO:0007031	24/407	peroxisome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
EOG8Z91BR	GO:0005779	24/407	integral component of peroxisomal membrane	cellular_component	"The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah]
EOG8Z91BR	GO:0043565	2/407	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8Z91BR	GO:0045944	2/407	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8Z91BR	GO:0048813	2/407	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8Z91BR	GO:0048592	2/407	eye morphogenesis	biological_process	"The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu]
EOG8Z91BR	GO:0001709	1/407	cell fate determination	biological_process	"A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
EOG8Z91BR	GO:0007469	1/407	antennal development	biological_process	"The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526]
EOG8Z91BR	GO:0000122	1/407	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8Z91BR	GO:0042675	1/407	compound eye cone cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu]
EOG8Z91BR	GO:0030154	1/407	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8Z91BR	GO:0045165	1/407	cell fate commitment	biological_process	"The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
EOG8Z91BR	GO:0048749	1/407	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8Z91BR	GO:0006366	1/407	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8Z91BR	GO:0003705	1/407	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG8Z91BR	GO:0035162	1/407	embryonic hemopoiesis	biological_process	"The stages of blood cell formation that take place within the embryo." [GOC:bf]
EOG8Z91BR	GO:0007486	1/407	imaginal disc-derived female genitalia development	biological_process	"The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
EOG8Z91BR	GO:0030097	1/407	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG8Z91BR	GO:0035170	1/407	lymph gland crystal cell differentiation	biological_process	"The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
EOG8Z91BR	GO:0042688	1/407	crystal cell differentiation	biological_process	"The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
EOG8Z91BR	GO:0035163	1/407	embryonic hemocyte differentiation	biological_process	"The process in which a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu, PMID:14602069]
EOG8Z91BR	GO:0045893	1/407	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Z91BR	GO:0035211	1/407	spermathecum morphogenesis	biological_process	"The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097]
EOG8Z91BR	GO:0016360	1/407	sensory organ precursor cell fate determination	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
EOG8Z91BR	GO:0046672	1/407	positive regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG8Z91BR	GO:0009987	1/407	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8Z91BR	GO:0007419	1/407	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8Z91BR	GO:0007165	1/407	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8Z91BR	GO:0045892	1/407	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Z91BR	GO:0035314	1/407	scab formation	biological_process	"Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection." [GOC:bf, PMID:15269788]
EOG8Z91BR	GO:0044212	1/407	transcription regulatory region DNA binding	molecular_function	"Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836]
EOG8Z91BR	GO:0048477	1/407	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8Z91BR	GO:0007377	1/407	germ-band extension	biological_process	"Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:08795694238]
EOG8Z91BR	GO:0035168	1/407	larval lymph gland hemocyte differentiation	biological_process	"The process in which a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:14602069]
EOG8Z91BR	GO:0045467	1/407	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8Z91BR	GO:0035165	1/407	embryonic crystal cell differentiation	biological_process	"The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
EOG8Z91BR	GO:0007366	1/407	periodic partitioning by pair rule gene	biological_process	"Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG8Z91BR	GO:0042060	1/407	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8Z91BR	GO:0007411	1/407	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8Z91BR	GO:0007400	1/407	neuroblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
EOG8Z91BR	GO:0007540	1/407	sex determination, establishment of X:A ratio	biological_process	"The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it." [GOC:isa_complete]
EOG8Z91BR	GO:0007367	1/407	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG8QC3NP	GO:0005549	19/69	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8QC3NP	GO:0005576	1/69	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8QC3NP	GO:0007606	1/69	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8642TN	GO:0016491	1/7	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8642TN	GO:0008670	1/7	2,4-dienoyl-CoA reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+." [EC:1.3.1.34]
EOG83BQ43	GO:0005737	14/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83BQ43	GO:0005634	14/86	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83BQ43	GO:0042994	1/86	cytoplasmic sequestering of transcription factor	biological_process	"The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl]
EOG83BQ43	GO:0032091	1/86	negative regulation of protein binding	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah]
EOG83BQ43	GO:0043433	1/86	negative regulation of sequence-specific DNA binding transcription factor activity	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl]
EOG83BQ43	GO:0043234	1/86	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG83BQ43	GO:0045879	1/86	negative regulation of smoothened signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG83BQ43	GO:0008134	1/86	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG83BQ40	GO:0030983	7/19	mismatched DNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]
EOG83BQ40	GO:0007131	7/19	reciprocal meiotic recombination	biological_process	"The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]
EOG83BQ40	GO:0032390	7/19	MutLbeta complex	cellular_component	"A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1." [GOC:vk]
EOG83BQ40	GO:0006298	7/19	mismatch repair	biological_process	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
EOG83BQ40	GO:0005524	7/19	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8Z91BB	GO:0015074	44/793	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8Z91BB	GO:0003676	43/793	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Z91BB	GO:0003964	17/793	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8Z91BB	GO:0003723	15/793	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8Z91BB	GO:0003677	6/793	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Z91BB	GO:0008270	4/793	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Z91BB	GO:0004523	2/793	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8Z91BB	GO:0005622	1/793	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8Z91BB	GO:0019028	1/793	viral capsid	cellular_component	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
EOG8Z91BB	GO:0046718	1/793	viral entry into host cell	biological_process	"The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm." [GOC:jl]
EOG8Z91BB	GO:0019076	1/793	viral release from host cell	biological_process	"The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane." [GOC:jl]
EOG8Z91BB	GO:0006351	1/793	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8Z91BB	GO:0003899	1/793	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8Z91BB	GO:0044163	1/793	host cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of host cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the host cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the host cell. The various elements of the host cytoskeleton not only serve in the maintenance of host cellular shape but also have roles in other host cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:rph]
EOG8Z91BB	GO:0075521	1/793	microtubule-dependent intracellular transport of viral material towards nucleus	biological_process	"The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules." [UniProtKB-KW:KW-1177, VZ:983]
EOG8Z91BB	GO:0042025	1/793	host cell nucleus	cellular_component	"A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
EOG8Z91BB	GO:0030430	1/793	host cell cytoplasm	cellular_component	"The cytoplasm of a host cell." [GOC:mah]
EOG8Z91BB	GO:0004190	1/793	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8KD936	GO:0016021	77/225	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KD936	GO:0005918	3/225	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG8KD936	GO:0019991	3/225	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG8KD936	GO:0060857	3/225	establishment of glial blood-brain barrier	biological_process	"Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
EOG8KD936	GO:0035151	2/225	regulation of tube size, open tracheal system	biological_process	"Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]
EOG8KD936	GO:0007424	2/225	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8KD936	GO:0005919	1/225	pleated septate junction	cellular_component	"A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298]
EOG8KD936	GO:0005198	1/225	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8KD936	GO:0005923	1/225	bicellular tight junction	cellular_component	"An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181]
EOG8KD936	GO:0005886	1/225	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8KD936	GO:0061343	1/225	cell adhesion involved in heart morphogenesis	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
EOG8KD936	GO:0005515	1/225	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KD936	GO:0035159	1/225	regulation of tube length, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
EOG8KD936	GO:0003015	1/225	heart process	biological_process	"A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]
EOG8KD936	GO:0007391	1/225	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8KD936	GO:0035002	1/225	liquid clearance, open tracheal system	biological_process	"The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352]
EOG8PVRGC	GO:0005549	63/151	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8PVRGC	GO:0005576	2/151	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8PVRGC	GO:0007606	2/151	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8PVRGC	GO:0005550	2/151	pheromone binding	molecular_function	"Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai]
EOG8PVRGC	GO:0006810	1/151	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8Z91BK	GO:0016020	68/151	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Z91BK	GO:0006810	68/151	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG866Z2S	GO:0007264	24/73	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG866Z2S	GO:0005622	24/73	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG866Z2S	GO:0005525	24/73	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG866Z2S	GO:0016020	23/73	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG866Z2S	GO:0007298	1/73	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG866Z2S	GO:0007155	1/73	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG866Z2S	GO:0007516	1/73	hemocyte development	biological_process	"The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG866Z2S	GO:0008360	1/73	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG866Z2S	GO:0030707	1/73	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG866Z2S	GO:0035011	1/73	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG866Z2S	GO:0006974	1/73	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG866Z2S	GO:0035099	1/73	hemocyte migration	biological_process	"The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551]
EOG866Z2S	GO:0007498	1/73	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG866Z2S	GO:0022409	1/73	positive regulation of cell-cell adhesion	biological_process	"Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
EOG866Z2S	GO:0005509	1/73	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG866Z2S	GO:0003924	1/73	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG866Z2S	GO:0006184	1/73	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG866Z2S	GO:0005886	1/73	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8GXJ31	GO:0007268	2/173	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8GXJ31	GO:0017121	1/173	phospholipid scrambling	biological_process	"The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE)." [GOC:cjm, PMID:20043909, PMID:20302864]
EOG8GXJ31	GO:0048812	1/173	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8GXJ31	GO:0017128	1/173	phospholipid scramblase activity	molecular_function	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864]
EOG8F20KH	GO:0046331	1/71	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG808QP2	GO:0020037	41/103	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG808QP2	GO:0004383	41/103	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG808QP2	GO:0035556	37/103	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG808QP2	GO:0000166	26/103	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG808QP2	GO:0008074	2/103	guanylate cyclase complex, soluble	cellular_component	"Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah]
EOG808QP2	GO:0046982	2/103	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG808QP2	GO:0046872	2/103	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG808QP2	GO:0001666	2/103	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG808QP2	GO:0005525	2/103	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG808QP2	GO:0006184	2/103	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG808QP2	GO:0000302	2/103	response to reactive oxygen species	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc]
EOG808QP2	GO:0006182	2/103	cGMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]
EOG808QP2	GO:0055093	1/103	response to hyperoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:kmv]
EOG89S8P2	GO:0000166	6/23	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG89S8P2	GO:0003676	5/23	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89S8P2	GO:0030529	1/23	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG89S8P2	GO:0032440	1/23	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG89S8P2	GO:0019013	1/23	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8MD0FN	GO:0007156	3/51	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8MD0FN	GO:0016021	3/51	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8MD0FN	GO:0005509	3/51	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8MD0FN	GO:0005886	3/51	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8X9B0N	GO:0003676	2/429	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X9B0N	GO:0003899	1/429	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8X9B0N	GO:0003677	1/429	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X9B0N	GO:0006351	1/429	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8X9B0N	GO:0031012	1/429	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8X9B0N	GO:0004222	1/429	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8X9B0N	GO:0008270	1/429	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80P6MP	GO:0005524	25/99	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG80P6MP	GO:0004672	25/99	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG80P6MP	GO:0035556	24/99	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG80P6MP	GO:0016021	23/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6MP	GO:0004383	23/99	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG80P6MP	GO:0001653	2/99	peptide receptor activity	molecular_function	"Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl]
EOG80P6MP	GO:0005887	2/99	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6MP	GO:0007428	2/99	primary branching, open tracheal system	biological_process	"Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG80P6MP	GO:0007526	2/99	larval somatic muscle development	biological_process	"The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG80P6MP	GO:0005886	2/99	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80P6MP	GO:0009651	2/99	response to salt stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]
EOG80P6MP	GO:0016199	2/99	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG80P6MP	GO:0008045	2/99	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG80P6MP	GO:0007435	2/99	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG80P6MP	GO:0004872	2/99	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG80P6MP	GO:0009190	1/99	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG80P6MP	GO:0016849	1/99	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG8FTZFX	GO:0016491	152/463	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8FTZFX	GO:0016630	12/463	protochlorophyllide reductase activity	molecular_function	"Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33]
EOG8FTZFX	GO:0004316	2/463	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
EOG8XD67H	GO:0016874	2/16	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8X0Q7R	GO:0003899	43/210	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8X0Q7R	GO:0003677	43/210	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X0Q7R	GO:0006351	43/210	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8X0Q7R	GO:0003676	4/210	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X0Q7R	GO:0046872	3/210	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8X0Q7R	GO:0008270	1/210	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X0Q7R	GO:0005634	1/210	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BS01X	GO:0020037	23/68	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8BS01X	GO:0046331	1/68	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8NW21W	GO:0006364	21/76	rRNA processing	biological_process	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
EOG8KSS06	GO:0007095	1/89	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8KSS06	GO:0005737	1/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8KSS06	GO:0035257	1/89	nuclear hormone receptor binding	molecular_function	"Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell." [GOC:bf]
EOG8KSS06	GO:0008231	1/89	repressor ecdysone receptor complex	cellular_component	"A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes." [PMID:10488333]
EOG8KSS06	GO:0003714	1/89	transcription corepressor activity	molecular_function	"Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8KSS06	GO:0022008	1/89	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8KSS06	GO:0008180	1/89	COP9 signalosome	cellular_component	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]
EOG8KSS06	GO:0007275	1/89	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8KSS06	GO:0005515	1/89	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KSS06	GO:0045892	1/89	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8KSS06	GO:0006909	1/89	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8KSS06	GO:0016922	1/89	ligand-dependent nuclear receptor binding	molecular_function	"Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein." [GOC:mah, PMID:7776974]
EOG8KSS06	GO:0042803	1/89	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8KSS06	GO:0048477	1/89	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8KSS06	GO:0050821	1/89	protein stabilization	biological_process	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]
EOG8KSS06	GO:0051726	1/89	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8BS01Q	GO:0051260	26/96	protein homooligomerization	biological_process	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
EOG8BS01Q	GO:0005886	1/96	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8BS01Q	GO:0004114	1/96	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular_function	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]
EOG8MSGC0	GO:0004601	52/183	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG8MSGC0	GO:0006979	52/183	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8MSGC0	GO:0020037	52/183	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8MSGC0	GO:0060967	1/183	negative regulation of gene silencing by RNA	biological_process	"Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb]
EOG8MSGC0	GO:0016758	1/183	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8MSGC0	GO:0070189	1/183	kynurenine metabolic process	biological_process	"The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph]
EOG8MSGC0	GO:0005764	1/183	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8MSGC0	GO:1901216	1/183	positive regulation of neuron death	biological_process	"Any process that activates or increases the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]
EOG8MSGC0	GO:0006727	1/183	ommochrome biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
EOG8FTZFK	GO:0003676	18/140	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FTZFK	GO:0046872	18/140	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WWV0T	GO:0016021	149/294	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WWV0T	GO:0008527	131/294	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8WWV0T	GO:0005886	29/294	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8WWV0T	GO:0050909	25/294	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8WWV0T	GO:0001582	8/294	detection of chemical stimulus involved in sensory perception of sweet taste	biological_process	"The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
EOG8WWV0T	GO:0050916	8/294	sensory perception of sweet taste	biological_process	"The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8WWV0T	GO:0033041	8/294	sweet taste receptor activity	molecular_function	"Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah]
EOG8WWV0T	GO:0050912	4/294	detection of chemical stimulus involved in sensory perception of taste	biological_process	"The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8WWV0T	GO:0007637	2/294	proboscis extension reflex	biological_process	"The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jid]
EOG8WWV0T	GO:0034289	1/294	detection of maltose stimulus	biological_process	"The series of events in which a maltose stimulus is received by a cell and converted into a molecular signal." [GOC:sart]
EOG8WWV0T	GO:0051594	1/294	detection of glucose	biological_process	"The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
EOG8WWV0T	GO:0010353	1/294	response to trehalose	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512]
EOG8WWV0T	GO:0009731	1/294	detection of sucrose stimulus	biological_process	"The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
EOG8MSGC8	GO:0005622	24/92	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8MSGC8	GO:0004198	24/92	calcium-dependent cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]
EOG8MSGC8	GO:0005509	24/92	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8MSGC8	GO:0005737	1/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG89W4VD	GO:0005737	1/97	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG89W4VD	GO:0001736	1/97	establishment of planar polarity	biological_process	"Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
EOG89W4VD	GO:0042067	1/97	establishment of ommatidial planar polarity	biological_process	"The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
EOG89W4VD	GO:0032440	1/97	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG89W4VD	GO:0005515	1/97	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG89W4VD	GO:0001737	1/97	establishment of imaginal disc-derived wing hair orientation	biological_process	"Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]
EOG8NP9H9	GO:0003676	3/51	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NP9H9	GO:0004523	2/51	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8NP9H9	GO:0008270	1/51	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DJNBJ	GO:0006788	22/75	heme oxidation	biological_process	"The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme." [GOC:mah]
EOG8DJNBJ	GO:0004392	22/75	heme oxygenase (decyclizing) activity	molecular_function	"Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O." [EC:1.14.99.3]
EOG8DJNBJ	GO:0042168	1/75	heme metabolic process	biological_process	"The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]
EOG89W4VC	GO:0055085	23/197	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG89W4VC	GO:0016021	23/197	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89W4VC	GO:0008340	1/197	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG89W4VC	GO:0016020	1/197	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG89W4VC	GO:0006810	1/197	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG89W4VC	GO:0004867	1/197	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG8B014R	GO:0003677	1/18	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8B014R	GO:0003899	1/18	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8B014R	GO:0006351	1/18	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG89W4VH	GO:0042157	1/12	lipoprotein metabolic process	biological_process	"The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732]
EOG89W4VH	GO:0008289	1/12	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG89W4VH	GO:0006869	1/12	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG89W4VH	GO:0005576	1/12	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG89W4VJ	GO:0016021	22/239	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89W4VJ	GO:0022891	15/239	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG89W4VJ	GO:0022857	6/239	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG89W4VJ	GO:0008643	1/239	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG89W4VK	GO:0016020	220/802	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG89W4VK	GO:0005524	220/802	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG89W4VK	GO:0016887	209/802	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG89W4VK	GO:0015416	10/802	organic phosphonate transmembrane-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:3.6.3.28]
EOG89W4VK	GO:0006909	1/802	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG89W4VK	GO:0042048	1/802	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG89W4VK	GO:0008559	1/802	xenobiotic-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44]
EOG89W4VK	GO:0022008	1/802	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG89W4VK	GO:0006641	1/802	triglyceride metabolic process	biological_process	"The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732]
EOG89W4VK	GO:0015439	1/802	heme-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [EC:3.6.3.41]
EOG89W4VK	GO:0045454	1/802	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8P8HXV	GO:0015031	2/97	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8B014J	GO:0046872	21/82	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89W4VS	GO:0006281	2/7	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG89W4VS	GO:0003678	2/7	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG89W4VS	GO:0000723	2/7	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG89W4VS	GO:0005524	1/7	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8B014B	GO:0005887	1/105	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8B014B	GO:0046331	1/105	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8J13R6	GO:0005622	24/59	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8J13R6	GO:0003779	1/59	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG80ZTBB	GO:0004725	1/97	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8DJNBG	GO:0008270	10/71	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DJNBG	GO:0016491	9/71	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8DJNBG	GO:0003960	1/71	NADPH:quinone reductase activity	molecular_function	"Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5]
EOG8B0144	GO:0008270	25/99	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8B0144	GO:0016740	2/99	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8B0144	GO:0005925	1/99	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8B0144	GO:0032319	1/99	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8B0144	GO:0010506	1/99	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8B0144	GO:1901739	1/99	regulation of myoblast fusion	biological_process	"Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]
EOG8B0144	GO:0035220	1/99	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8B0144	GO:0035218	1/99	leg disc development	biological_process	"Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
EOG8B0144	GO:0046843	1/99	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8B0144	GO:0007016	1/99	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG86T5HT	GO:0004672	1/4	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG86T5HT	GO:0005524	1/4	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8TMTG5	GO:0016021	41/138	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TMTG5	GO:0004930	24/138	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8TMTG5	GO:0004997	16/138	thyrotropin-releasing hormone receptor activity	molecular_function	"Combining with thyrotropin-releasing hormone to initiate a change in cell activity." [GOC:mah]
EOG8TMTG5	GO:0005887	1/138	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TMTG5	GO:0007218	1/138	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8TMTG5	GO:0008227	1/138	G-protein coupled amine receptor activity	molecular_function	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
EOG8TMTG5	GO:0042654	1/138	ecdysis-triggering hormone receptor activity	molecular_function	"Combining with ecdysis-triggering hormone to initiate a change in cell activity." [GOC:ma]
EOG8TMTG5	GO:0009755	1/138	hormone-mediated signaling pathway	biological_process	"A series of molecular signals mediated by the detection of a hormone." [GOC:sm]
EOG8TMTG5	GO:0022008	1/138	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8TMTG5	GO:0007186	1/138	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8TMTG5	GO:0008188	1/138	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8TMTG5	GO:0048812	1/138	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8TMTG5	GO:0008528	1/138	G-protein coupled peptide receptor activity	molecular_function	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]
EOG8MSGCD	GO:0000042	22/95	protein targeting to Golgi	biological_process	"The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah]
EOG8MSGCD	GO:0046331	1/95	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8MSGCD	GO:0048047	1/95	mating behavior, sex discrimination	biological_process	"The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700]
EOG8MSGCD	GO:0008049	1/95	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8MSGCD	GO:0007619	1/95	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG8MSGCD	GO:0016301	1/95	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8TMTG2	GO:0005524	23/85	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8TMTG2	GO:0004674	21/85	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8TMTG2	GO:0004672	2/85	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8TMTG2	GO:0031398	1/85	positive regulation of protein ubiquitination	biological_process	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]
EOG8TMTG2	GO:0016020	1/85	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8TMTG2	GO:0043234	1/85	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8TMTG2	GO:0005515	1/85	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8TMTG2	GO:0007228	1/85	positive regulation of hh target transcription factor activity	biological_process	"Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited." [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936]
EOG8TMTG2	GO:0006468	1/85	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8TMTG2	GO:0007293	1/85	germarium-derived egg chamber formation	biological_process	"Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8TMTG2	GO:0031647	1/85	regulation of protein stability	biological_process	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]
EOG8TMTG2	GO:0003723	1/85	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8TMTG2	GO:0035301	1/85	Hedgehog signaling complex	cellular_component	"A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila)." [PMID:10825151, PMID:15057936]
EOG8TMTG2	GO:0030162	1/85	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8TMTG2	GO:0030514	1/85	negative regulation of BMP signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators]
EOG8TMTG2	GO:0003964	1/85	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8TMTG2	GO:0007224	1/85	smoothened signaling pathway	biological_process	"A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
EOG8TMTG2	GO:0042993	1/85	positive regulation of transcription factor import into nucleus	biological_process	"Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]
EOG8TMTG2	GO:0007367	1/85	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG86T5HW	GO:0005681	11/34	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG86T5HW	GO:0000398	11/34	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG86T5HW	GO:0019013	2/34	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG86T5HW	GO:0003723	1/34	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG86T5HW	GO:0071011	1/34	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG86T5HW	GO:0005634	1/34	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86T5HW	GO:0071013	1/34	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG86T5HW	GO:0030532	1/34	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8MSGCJ	GO:0005634	5/68	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8MSGCJ	GO:0008270	5/68	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MSGCJ	GO:0003676	3/68	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KSS0T	GO:0005887	1/55	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BS012	GO:0005524	22/102	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8BS012	GO:0004713	20/102	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8BS012	GO:0004715	3/102	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8BS012	GO:0007411	1/102	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8BS012	GO:0007391	1/102	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8BS012	GO:0016301	1/102	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8BS012	GO:0006468	1/102	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8BS012	GO:0018108	1/102	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG8BS012	GO:0005912	1/102	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8BS012	GO:0046664	1/102	dorsal closure, amnioserosa morphology change	biological_process	"The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138]
EOG8BS012	GO:0005543	1/102	phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8BS012	GO:0005886	1/102	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8BS012	GO:0051017	1/102	actin filament bundle assembly	biological_process	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
EOG8BS012	GO:0007394	1/102	dorsal closure, elongation of leading edge cells	biological_process	"The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138]
EOG8BS012	GO:0019898	1/102	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8KSS0M	GO:0008270	28/97	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KSS0M	GO:0003676	1/97	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WWV07	GO:0003676	6/13	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NP9HH	GO:0006306	4/42	DNA methylation	biological_process	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]
EOG8NP9HH	GO:0008168	4/42	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8NP9HH	GO:0003677	4/42	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NP9HH	GO:0008270	1/42	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83FKD8	GO:0008270	7/84	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83FKD8	GO:0003723	4/84	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG83FKD8	GO:0003964	4/84	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG83FKD8	GO:0003676	2/84	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83FKD8	GO:0003678	1/84	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG83FKD8	GO:0005524	1/84	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG83FKD8	GO:0007018	1/84	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG83FKD8	GO:0003777	1/84	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG83FKD8	GO:0015074	1/84	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG83FKD8	GO:0006281	1/84	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG83FKD8	GO:0000723	1/84	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG83FKD0	GO:0005737	3/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83FKD0	GO:0006886	2/94	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG83FKD0	GO:0090382	1/94	phagosome maturation	biological_process	"A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome." [GOC:kmv, GOC:tb]
EOG83FKD0	GO:0090385	1/94	phagosome-lysosome fusion	biological_process	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]
EOG83FKD0	GO:0006955	1/94	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG83FKD0	GO:0016197	1/94	endosomal transport	biological_process	"The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]
EOG83FKD0	GO:0005515	1/94	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG83FKD0	GO:0035542	1/94	regulation of SNARE complex assembly	biological_process	"Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
EOG83FKD0	GO:0030897	1/94	HOPS complex	cellular_component	"A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161]
EOG83FKD0	GO:0033263	1/94	CORVET complex	cellular_component	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]
EOG8XH2G2	GO:0008270	22/81	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XH2G2	GO:0016874	1/81	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8284H5	GO:0016021	71/178	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG898XDV	GO:0004114	24/98	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular_function	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]
EOG898XDV	GO:0007165	23/98	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG898XDV	GO:0046872	22/98	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG898XDV	GO:0019933	1/98	cAMP-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
EOG898XDV	GO:0001661	1/98	conditioned taste aversion	biological_process	"A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659]
EOG898XDV	GO:0046958	1/98	nonassociative learning	biological_process	"A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment." [ISBN:0582227089]
EOG898XDV	GO:0000003	1/98	reproduction	biological_process	"The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732]
EOG898XDV	GO:0007614	1/98	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG898XDV	GO:0040040	1/98	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG898XDV	GO:0007619	1/98	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG898XDV	GO:0007617	1/98	mating behavior	biological_process	"The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph]
EOG898XDV	GO:0007613	1/98	memory	biological_process	"The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089]
EOG898XDV	GO:0010738	1/98	regulation of protein kinase A signaling	biological_process	"Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]
EOG898XDV	GO:0048149	1/98	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG898XDV	GO:0046331	1/98	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG898XDV	GO:0007611	1/98	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG898XDV	GO:0007623	1/98	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG898XDV	GO:0008355	1/98	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG898XDV	GO:0006198	1/98	cAMP catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]
EOG898XDV	GO:0045475	1/98	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG898XDV	GO:0048675	1/98	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG898XDV	GO:0008306	1/98	associative learning	biological_process	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
EOG898XDV	GO:0007268	1/98	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG898XDV	GO:0007612	1/98	learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544]
EOG898XDV	GO:0048477	1/98	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG80KBG6	GO:0046872	2/9	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80KBG6	GO:0003676	2/9	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG86X1PC	GO:0005509	21/105	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG86X1PC	GO:0045746	1/105	negative regulation of Notch signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG86X1PC	GO:0008582	1/105	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG86X1PC	GO:0007269	1/105	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG86X1PC	GO:0048488	1/105	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG86X1PC	GO:0006898	1/105	receptor-mediated endocytosis	biological_process	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
EOG8BP3W3	GO:0051289	16/34	protein homotetramerization	biological_process	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]
EOG8BP3W3	GO:0008140	16/34	cAMP response element binding protein binding	molecular_function	"Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein)." [GOC:mah]
EOG8BP3W3	GO:0032793	16/34	positive regulation of CREB transcription factor activity	biological_process	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb]
EOG8BP3W3	GO:0005634	16/34	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BP3W3	GO:0005737	16/34	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8BP3W3	GO:0042594	1/34	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8BP3W3	GO:0006979	1/34	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG89S8M6	GO:0005737	20/105	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG89S8M6	GO:0050807	2/105	regulation of synapse organization	biological_process	"Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]
EOG89S8M6	GO:0030866	2/105	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG89S8M6	GO:0031209	2/105	SCAR complex	cellular_component	"A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:pg, PMID:12181570]
EOG89S8M6	GO:0007411	2/105	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG89S8M6	GO:0022416	2/105	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG89S8M6	GO:0008360	2/105	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG89S8M6	GO:0030031	2/105	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG89S8M6	GO:0006909	1/105	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG89S8M6	GO:0005515	1/105	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG89S8M6	GO:0045177	1/105	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG89S8M6	GO:0001745	1/105	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG89S8M6	GO:0046872	1/105	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89S8M6	GO:0000902	1/105	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8MPM68	GO:0005549	4/54	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8NP9HB	GO:0016021	35/123	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NP9HB	GO:0005886	34/123	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8NP9HB	GO:0007218	33/123	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8NP9HB	GO:0004930	32/123	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8NP9HB	GO:0030246	25/123	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8NP9HB	GO:0016192	1/123	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8NP9HB	GO:0004888	1/123	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8NP9HB	GO:0007269	1/123	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8NP9HB	GO:0008021	1/123	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8NP9HB	GO:0007186	1/123	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8NP9HB	GO:0016524	1/123	latrotoxin receptor activity	molecular_function	"Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling, PMID:10025961]
EOG8MPM6K	GO:0005789	14/64	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8MPM6K	GO:0006506	14/64	GPI anchor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
EOG85HVHB	GO:0003676	1/63	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85HVHB	GO:0046872	1/63	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8R26BJ	GO:0015991	65/111	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8R26BJ	GO:0015078	65/111	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG8R26BJ	GO:0033179	63/111	proton-transporting V-type ATPase, V0 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG8R26BJ	GO:0016787	5/111	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8R26BJ	GO:0000220	2/111	vacuolar proton-transporting V-type ATPase, V0 domain	cellular_component	"The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG8R26BJ	GO:0033181	1/111	plasma membrane proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
EOG8R26BJ	GO:0005886	1/111	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8QVFT6	GO:0016021	5/19	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QVFT6	GO:0004983	4/19	neuropeptide Y receptor activity	molecular_function	"Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
EOG8QVFT6	GO:0004930	1/19	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG85F038	GO:0007165	47/190	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG85F038	GO:0046872	44/190	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85F038	GO:0004114	31/190	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular_function	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]
EOG85F038	GO:0047555	16/190	3',5'-cyclic-GMP phosphodiesterase activity	molecular_function	"Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate." [EC:3.1.4.35, MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN]
EOG85F038	GO:0046068	13/190	cGMP metabolic process	biological_process	"The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators]
EOG85F038	GO:0016020	12/190	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG85F038	GO:0005886	12/190	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG85F038	GO:0005515	1/190	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG85F038	GO:0032240	1/190	negative regulation of nucleobase-containing compound transport	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG85F038	GO:0004115	1/190	3',5'-cyclic-AMP phosphodiesterase activity	molecular_function	"Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate." [GOC:ai]
EOG85F038	GO:0016324	1/190	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG85F038	GO:0046331	1/190	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG85F038	GO:0046058	1/190	cAMP metabolic process	biological_process	"The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:go_curators]
EOG8GTNSV	GO:0005097	28/103	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG88KTV9	GO:0016301	1/63	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8BVVBT	GO:0050829	1/51	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8BVVBT	GO:0008157	1/51	protein phosphatase 1 binding	molecular_function	"Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl]
EOG8BVVBT	GO:0045089	1/51	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG87H85J	GO:0070822	1/107	Sin3-type complex	cellular_component	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]
EOG8DBWTD	GO:0016021	28/140	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DBWTD	GO:0005219	27/140	ryanodine-sensitive calcium-release channel activity	molecular_function	"Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb]
EOG8DBWTD	GO:0006874	27/140	cellular calcium ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah]
EOG8DBWTD	GO:0005509	22/140	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8DBWTD	GO:0016020	5/140	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8DBWTD	GO:0005262	4/140	calcium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8DBWTD	GO:0035206	1/140	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8DBWTD	GO:0060047	1/140	heart contraction	biological_process	"The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph]
EOG8DBWTD	GO:0033017	1/140	sarcoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the sarcoplasmic reticulum." [GOC:rph]
EOG8DBWTD	GO:0005875	1/140	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8DBWTD	GO:0072347	1/140	response to anesthetic	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart]
EOG8DBWTD	GO:0006936	1/140	muscle contraction	biological_process	"A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]
EOG8DBWTD	GO:0007275	1/140	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8DBWTD	GO:0005216	1/140	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8DBWTD	GO:0006816	1/140	calcium ion transport	biological_process	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8XH2GQ	GO:0042302	1098/2997	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8XH2GQ	GO:0031012	32/2997	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8XH2GQ	GO:0040003	31/2997	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8XH2GQ	GO:0008010	31/2997	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8XH2GQ	GO:0022008	2/2997	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8XH2GQ	GO:0008011	2/2997	structural constituent of pupal chitin-based cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8XH2GQ	GO:0032504	1/2997	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8XH2GQ	GO:0048058	1/2997	compound eye corneal lens development	biological_process	"The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells." [GOC:jid]
EOG8XH2GQ	GO:0005615	1/2997	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8XH2GQ	GO:0005212	1/2997	structural constituent of eye lens	molecular_function	"The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah]
EOG8XH2GQ	GO:0005576	1/2997	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8XH2GQ	GO:0005509	1/2997	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8XH2GQ	GO:0007601	1/2997	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8XH2GQ	GO:0003824	1/2997	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8XH2GQ	GO:0005811	1/2997	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8DBWTP	GO:0031931	21/94	TORC1 complex	cellular_component	"A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787]
EOG8DBWTP	GO:0031929	21/94	TOR signaling	biological_process	"A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]
EOG8DBWTP	GO:0003993	7/94	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG8DBWTP	GO:0006974	1/94	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8DBWTP	GO:0045886	1/94	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8DBWTP	GO:0001934	1/94	positive regulation of protein phosphorylation	biological_process	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
EOG8DBWTP	GO:0007411	1/94	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8DBWTW	GO:0016021	122/391	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DBWTW	GO:0022857	118/391	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8DBWTW	GO:0055085	3/391	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8DBWTW	GO:0005215	2/391	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8DBWTW	GO:0007390	1/391	germ-band shortening	biological_process	"The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138]
EOG8DBWTW	GO:0008643	1/391	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8DBWTW	GO:0015695	1/391	organic cation transport	biological_process	"The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai]
EOG8DBWTW	GO:0030307	1/391	positive regulation of cell growth	biological_process	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8DBWTW	GO:0015101	1/391	organic cation transmembrane transporter activity	molecular_function	"Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8DBWTW	GO:0040018	1/391	positive regulation of multicellular organism growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8DBWTW	GO:0006915	1/391	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8DBWTW	GO:0006811	1/391	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8DBWTW	GO:0032440	1/391	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG84QWG5	GO:0003677	12/80	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84QWG5	GO:0003676	8/80	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84QWG4	GO:0016874	2/12	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG80CKXW	GO:0008270	3/39	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80CKXW	GO:0003676	2/39	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80CKXW	GO:0003964	1/39	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG80CKXW	GO:0003723	1/39	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG80CKXW	GO:0015074	1/39	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8Q2GW6	GO:0003995	76/231	acyl-CoA dehydrogenase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]
EOG8Q2GW6	GO:0050660	74/231	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8Q2GW6	GO:0048813	1/231	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8Q2GW6	GO:0006367	1/231	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG8Q2GW6	GO:0005739	1/231	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8Q2GW6	GO:0001104	1/231	RNA polymerase II transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8Q2GW6	GO:0006357	1/231	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8Q2GW6	GO:0016592	1/231	mediator complex	cellular_component	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
EOG8Q2GW6	GO:0043958	1/231	acryloyl-CoA reductase activity	molecular_function	"Catalysis of the reaction: acryloyl-CoA + NADH + H+ + a reduced electron-transfer flavoprotein = propionyl-CoA + NAD+ + an oxidized electron-transfer flavoprotein." [GOC:jl, PMID:12603323]
EOG854CCF	GO:0006357	35/129	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG854CCF	GO:0032784	35/129	regulation of DNA-templated transcription, elongation	biological_process	"Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]
EOG854CCF	GO:0016788	32/129	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG854CCF	GO:0006139	31/129	nucleobase-containing compound metabolic process	biological_process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
EOG854CCF	GO:0003723	26/129	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG854CCF	GO:0003677	26/129	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG854CCF	GO:0003676	3/129	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG854CCF	GO:0003746	2/129	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG854CCF	GO:0006366	1/129	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG854CCF	GO:0006511	1/129	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG854CCF	GO:0032968	1/129	positive regulation of transcription elongation from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
EOG854CCF	GO:0005634	1/129	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG854CCF	GO:0005509	1/129	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG854CCF	GO:0003682	1/129	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG854CCF	GO:0035363	1/129	histone locus body	cellular_component	"A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body." [GOC:sart, PMID:16533947, PMID:18927579, PMID:19620235]
EOG854CCF	GO:0005703	1/129	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG854CCF	GO:0002805	1/129	regulation of antimicrobial peptide biosynthetic process	biological_process	"Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
EOG854CCF	GO:0005705	1/129	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG854CCF	GO:0035327	1/129	transcriptionally active chromatin	cellular_component	"The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872]
EOG854CCF	GO:0008023	1/129	transcription elongation factor complex	cellular_component	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]
EOG854CCF	GO:0004843	1/129	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG8K3P9W	GO:0003913	2/7	DNA photolyase activity	molecular_function	"Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949]
EOG8K3P9W	GO:0006281	2/7	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8Q2GW0	GO:0000184	26/94	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	biological_process	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]
EOG8K3P9K	GO:0005057	2/41	receptor signaling protein activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf]
EOG8K3P9K	GO:0030695	2/41	GTPase regulator activity	molecular_function	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
EOG8K3P9K	GO:0038032	2/41	termination of G-protein coupled receptor signaling pathway	biological_process	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]
EOG822D17	GO:0016021	2/37	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG854CCT	GO:0016021	1/121	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8K3P9D	GO:0003677	1/6	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8K3P9D	GO:0003899	1/6	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8K3P9D	GO:0006351	1/6	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8K3P9D	GO:0032549	1/6	ribonucleoside binding	molecular_function	"Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah]
EOG84N1B2	GO:0008236	1/2	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8WHC1B	GO:0008270	2/68	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WHC1B	GO:0032440	1/68	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG81VNHV	GO:0006309	21/82	apoptotic DNA fragmentation	biological_process	"The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520]
EOG81VNHV	GO:0005737	21/82	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG81VNHV	GO:0016787	20/82	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG81VNHV	GO:0005634	20/82	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81VNHV	GO:0005622	2/82	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG81VNHV	GO:0006915	2/82	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG81VNHV	GO:0000790	1/82	nuclear chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130]
EOG81VNHV	GO:0004536	1/82	deoxyribonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684]
EOG82C0RB	GO:0003676	26/100	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82C0RB	GO:0004527	25/100	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8GQSJZ	GO:0046330	1/92	positive regulation of JNK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8GQSJZ	GO:0005515	1/92	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8GQSJZ	GO:0030041	1/92	actin filament polymerization	biological_process	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG81VNHC	GO:0046907	28/118	intracellular transport	biological_process	"The directed movement of substances within a cell." [GOC:ai]
EOG81VNHC	GO:0005643	25/118	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG81VNHC	GO:0022008	1/118	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG81VNHC	GO:0006909	1/118	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG81VNHC	GO:0005515	1/118	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG81VNHC	GO:0008236	1/118	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG81VNHC	GO:0007184	1/118	SMAD protein import into nucleus	biological_process	"The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph]
EOG82FVZP	GO:0000062	18/68	fatty-acyl-CoA binding	molecular_function	"Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732]
EOG82FVZP	GO:0004190	1/68	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG82FVZP	GO:0003676	1/68	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82FVZP	GO:0000166	1/68	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG81VNH1	GO:0016021	1/46	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C8B8M	GO:0016491	1/6	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG83BQ5H	GO:0016020	2/21	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG83BQ5H	GO:0000155	2/21	phosphorelay sensor kinase activity	molecular_function	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
EOG83BQ5H	GO:0005249	2/21	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG84N1BN	GO:0003677	3/12	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Z38TP	GO:0030246	39/110	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8Z38TP	GO:0004360	38/110	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	molecular_function	"Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate." [EC:2.6.1.16, RHEA:13240]
EOG8Z38TP	GO:0016051	37/110	carbohydrate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]
EOG8Z38TP	GO:0005975	2/110	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8Z38TP	GO:0004044	1/110	amidophosphoribosyltransferase activity	molecular_function	"Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O." [EC:2.4.2.14, RHEA:14908]
EOG80CKX2	GO:0003676	25/86	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80CKX2	GO:0005524	25/86	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG80CKX2	GO:0008026	24/86	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG80CKX2	GO:0004386	2/86	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG80CKX2	GO:0071011	1/86	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG80CKX2	GO:0032797	1/86	SMN complex	cellular_component	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]
EOG80CKX2	GO:0016779	1/86	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG80CKX2	GO:0000398	1/86	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG80CKX2	GO:0071013	1/86	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8FR36H	GO:0042826	2/100	histone deacetylase binding	molecular_function	"Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl]
EOG8FR36H	GO:0010629	2/100	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8FR36H	GO:0005634	1/100	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FR36H	GO:0008168	1/100	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8FR36H	GO:0005737	1/100	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Q2GWW	GO:0032994	1/143	protein-lipid complex	cellular_component	"A macromolecular complex containing separate protein and lipid molecules.  Separate in this context means not covalently bound to each other." [GOC:mah]
EOG8Q2GWW	GO:0006869	1/143	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG8Q2GWW	GO:0006642	1/143	triglyceride mobilization	biological_process	"The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625]
EOG8Q2GWW	GO:0005737	1/143	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Q2GWW	GO:0010898	1/143	positive regulation of triglyceride catabolic process	biological_process	"Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb]
EOG8Q2GWW	GO:0005811	1/143	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8Q2GWW	GO:0034389	1/143	lipid particle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201]
EOG8Q2GWW	GO:1990044	1/143	protein localization to lipid particle	biological_process	"A process in which a protein is transported to, or maintained in, a location on or within a lipid particle." [GOC:sart, PMID:22505614]
EOG8Q2GWW	GO:0022008	1/143	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8Q2GWW	GO:0019915	1/143	lipid storage	biological_process	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]
EOG8Q2GWW	GO:0010883	1/143	regulation of lipid storage	biological_process	"Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
EOG8935XV	GO:0006914	2/106	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG8935XV	GO:0046331	1/106	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8FR36G	GO:0016021	86/188	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FR36G	GO:0055085	85/188	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8FR36G	GO:0005215	29/188	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8FR36G	GO:0031427	1/188	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG8FR36G	GO:0052591	1/188	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	molecular_function	"Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." [MetaCyc:GLYC3PDEHYDROG-RXN]
EOG8FR36G	GO:0006072	1/188	glycerol-3-phosphate metabolic process	biological_process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]
EOG8FR36G	GO:0022857	1/188	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8FR36G	GO:0009331	1/188	glycerol-3-phosphate dehydrogenase complex	cellular_component	"An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3]
EOG8Q2GWR	GO:0016787	62/163	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8Q2GWR	GO:0046872	1/163	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Q2GWR	GO:0008270	1/163	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q2GWR	GO:0008801	1/163	beta-phosphoglucomutase activity	molecular_function	"Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate." [EC:5.4.2.6, RHEA:20116]
EOG8Q2GWR	GO:0003676	1/163	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q2GWR	GO:0009117	1/163	nucleotide metabolic process	biological_process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]
EOG8Q2GWR	GO:0016791	1/163	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG8Q2GWR	GO:0042060	1/163	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG84QWGX	GO:0006457	25/85	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG84QWGX	GO:0016272	25/85	prefoldin complex	cellular_component	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]
EOG84QWGX	GO:0022008	1/85	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8Q2GWH	GO:0003676	13/42	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q2GWH	GO:0046872	1/42	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z38TH	GO:0003676	2/152	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Z38TH	GO:0016788	2/152	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG8Z38TH	GO:0019090	1/152	mitochondrial rRNA export from mitochondrion	biological_process	"The directed movement of mitochondrial rRNA out of a mitochondrion." [GOC:ai]
EOG8Z38TH	GO:0046872	1/152	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z38TH	GO:0045495	1/152	pole plasm	cellular_component	"Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380]
EOG8Z38TH	GO:0030719	1/152	P granule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367]
EOG8Z38TH	GO:0008168	1/152	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8Z38TH	GO:0005737	1/152	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Z38TH	GO:0043186	1/152	P granule	cellular_component	"A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
EOG8Z38TH	GO:0007281	1/152	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8Z38TH	GO:0003677	1/152	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Z38TH	GO:0006306	1/152	DNA methylation	biological_process	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]
EOG8Z38TH	GO:0007277	1/152	pole cell development	biological_process	"The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jid]
EOG8Z38TH	GO:0003723	1/152	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8Z38TH	GO:0008298	1/152	intracellular mRNA localization	biological_process	"Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai]
EOG8Z38TH	GO:0005739	1/152	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8Z38TH	GO:0005515	1/152	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8Z38TH	GO:0005634	1/152	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z38TH	GO:0007315	1/152	pole plasm assembly	biological_process	"Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8FR36Q	GO:0005097	25/83	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG89PDFN	GO:0005549	1/113	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG84QWGK	GO:0042302	90/953	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG84QWGK	GO:0032784	4/953	regulation of DNA-templated transcription, elongation	biological_process	"Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]
EOG84QWGK	GO:0031012	4/953	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG84QWGK	GO:0006357	4/953	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG84QWGK	GO:0008010	3/953	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG84QWGK	GO:0040003	3/953	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG84QWGK	GO:0005576	2/953	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG84QWGK	GO:0003677	2/953	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84QWGK	GO:0008061	2/953	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG84QWGK	GO:0006334	1/953	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG84QWGK	GO:0022008	1/953	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84QWGK	GO:0003676	1/953	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84QWGK	GO:0030023	1/953	extracellular matrix constituent conferring elasticity	molecular_function	"A component of the extracellular matrix that enables the matrix to recoil after transient stretching." [GOC:mah, ISBN:0815316194]
EOG84QWGK	GO:0005737	1/953	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84QWGK	GO:0000786	1/953	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG84QWGK	GO:0016874	1/953	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG84QWGK	GO:0018149	1/953	peptide cross-linking	biological_process	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]
EOG84QWGK	GO:0005201	1/953	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG84QWGK	GO:0005634	1/953	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84QWGK	GO:0006030	1/953	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG84QWGK	GO:0032992	1/953	protein-carbohydrate complex	cellular_component	"A macromolecular complex containing separate protein and carbohydrate molecules.  Separate in this context means not covalently bound to each other." [GOC:mah]
EOG8QFZV3	GO:0005975	201/525	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8QFZV3	GO:0043169	199/525	cation binding	molecular_function	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]
EOG8QFZV3	GO:0003824	188/525	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8QFZV3	GO:0032450	12/525	maltose alpha-glucosidase activity	molecular_function	"Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141]
EOG8QFZV3	GO:0016740	1/525	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8QFZV3	GO:0003677	1/525	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Q87CX	GO:0016491	2/5	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8Q87CX	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q87CX	GO:0005351	1/5	sugar:proton symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]
EOG8Q87CX	GO:0006355	1/5	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Q87CX	GO:0009401	1/5	phosphoenolpyruvate-dependent sugar phosphotransferase system	biological_process	"The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html]
EOG8Q87CX	GO:0008982	1/5	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	molecular_function	"Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-]
EOG8PVRFV	GO:0008270	2/13	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PVRFV	GO:0003676	2/13	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8PVRFV	GO:0015074	1/13	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8PVRFB	GO:0016740	11/149	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8PVRFB	GO:0004364	4/149	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG8PVRFB	GO:0006749	3/149	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG8PVRFB	GO:0018834	1/149	dichloromethane dehalogenase activity	molecular_function	"Catalysis of the reaction: dichloromethane + H(2)O = 2 chloride + formaldehyde + 2 H(+)." [EC:4.5.1.3, RHEA:15400]
EOG8NKF98	GO:0016021	134/389	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NKF98	GO:0007602	130/389	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG8NKF98	GO:0007601	128/389	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8NKF98	GO:0004930	128/389	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8NKF98	GO:0018298	122/389	protein-chromophore linkage	biological_process	"The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma]
EOG8NKF98	GO:0009881	116/389	photoreceptor activity	molecular_function	"The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators]
EOG8NKF98	GO:0009584	6/389	detection of visible light	biological_process	"The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
EOG8NKF98	GO:0008020	6/389	G-protein coupled photoreceptor activity	molecular_function	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]
EOG8NKF98	GO:0007186	6/389	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8NKF98	GO:0009589	3/389	detection of UV	biological_process	"The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:dos, GOC:go_curators, GOC:hb, ISBN:0198506732]
EOG8NKF98	GO:0016028	3/389	rhabdomere	cellular_component	"The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774]
EOG8NKF98	GO:0007604	2/389	phototransduction, UV	biological_process	"The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers." [GOC:go_curators, ISBN:0198506732]
EOG8NKF98	GO:0043153	2/389	entrainment of circadian clock by photoperiod	biological_process	"The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl]
EOG8NKF98	GO:0007605	2/389	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8NKF98	GO:0005767	1/389	secondary lysosome	cellular_component	"Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, ISBN:0815316194]
EOG8NKF98	GO:0009642	1/389	response to light intensity	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:go_curators]
EOG8NKF98	GO:0008344	1/389	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG8NKF98	GO:0042052	1/389	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8NKF98	GO:0043052	1/389	thermotaxis	biological_process	"The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
EOG8NKF98	GO:0008594	1/389	photoreceptor cell morphogenesis	biological_process	"The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
EOG8NKF98	GO:0016027	1/389	inaD signaling complex	cellular_component	"A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815]
EOG8NKF98	GO:0009416	1/389	response to light stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
EOG8NKF98	GO:0030265	1/389	phospholipase C-activating rhodopsin mediated signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a rhodopsin molecule being activated by a photon, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:mah, GOC:signaling, PMID:22498302, PMID:8823931]
EOG8NKF98	GO:0046673	1/389	negative regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG8NKF98	GO:0042331	1/389	phototaxis	biological_process	"The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981]
EOG8NKF98	GO:0016038	1/389	absorption of visible light	biological_process	"The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm." [GOC:go_curators, ISBN:0198506732]
EOG8NKF98	GO:0005771	1/389	multivesicular body	cellular_component	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]
EOG8NKF98	GO:0016039	1/389	absorption of UV light	biological_process	"The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm." [GOC:go_curators, ISBN:0198506732]
EOG8NKF98	GO:0005791	1/389	rough endoplasmic reticulum	cellular_component	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]
EOG8NKF98	GO:0016023	1/389	cytoplasmic membrane-bounded vesicle	cellular_component	"A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
EOG8NKF98	GO:0009588	1/389	UV-A, blue light phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of 315 to 400 nm." [GOC:mah]
EOG8NKF98	GO:0016029	1/389	subrhabdomeral cisterna	cellular_component	"A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase." [PMID:11707492, PMID:8646774]
EOG8NKF98	GO:0005515	1/389	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8NKF98	GO:0000122	1/389	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8NKF98	GO:0071632	1/389	optomotor response	biological_process	"Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish." [GOC:dos, PMID:12726833, PMID:2469195]
EOG8NKF98	GO:0005886	1/389	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8FFGG5	GO:0005524	25/97	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8FFGG5	GO:0006457	25/97	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8FFGG5	GO:0017111	25/97	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8FFGG5	GO:0008233	3/97	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8K6JJQ	GO:0005525	3/86	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8K6JJQ	GO:0007049	3/86	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG8K6JJQ	GO:0015074	1/86	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8K6JJQ	GO:0003676	1/86	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W10TJ	GO:0032312	9/67	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8W10TJ	GO:0008270	9/67	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8W10TJ	GO:0008060	9/67	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8QJV20	GO:0005524	124/478	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QJV20	GO:0004713	95/478	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8QJV20	GO:0004715	33/478	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8QJV20	GO:0035556	18/478	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8QJV20	GO:0006468	5/478	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8QJV20	GO:0018108	5/478	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG8QJV20	GO:0004672	4/478	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8QJV20	GO:0007391	4/478	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8QJV20	GO:0045886	3/478	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8QJV20	GO:0007435	3/478	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8QJV20	GO:0007254	3/478	JNK cascade	biological_process	"An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974]
EOG8QJV20	GO:0007424	3/478	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8QJV20	GO:0030036	2/478	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8QJV20	GO:0030723	2/478	ovarian fusome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]
EOG8QJV20	GO:0048749	2/478	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8QJV20	GO:0045172	2/478	germline ring canal	cellular_component	"Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801]
EOG8QJV20	GO:0005515	2/478	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QJV20	GO:0030717	2/478	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG8QJV20	GO:0005737	2/478	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8QJV20	GO:0007293	2/478	germarium-derived egg chamber formation	biological_process	"Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8QJV20	GO:0034332	2/478	adherens junction organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah]
EOG8QJV20	GO:0007349	2/478	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG8QJV20	GO:0090136	2/478	epithelial cell-cell adhesion	biological_process	"The attachment of an epithelial cell to another epithelial cell via adhesion molecules." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8QJV20	GO:0007476	2/478	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8QJV20	GO:0008064	2/478	regulation of actin polymerization or depolymerization	biological_process	"Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]
EOG8QJV20	GO:0007300	2/478	ovarian nurse cell to oocyte transport	biological_process	"Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8QJV20	GO:0048477	2/478	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8QJV20	GO:0005912	2/478	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8QJV20	GO:0007301	2/478	female germline ring canal formation	biological_process	"Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238]
EOG8QJV20	GO:0007169	1/478	transmembrane receptor protein tyrosine kinase signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
EOG8QJV20	GO:0046872	1/478	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QJV20	GO:0046960	1/478	sensitization	biological_process	"An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched." [ISBN:0582227089]
EOG8QJV20	GO:0007409	1/478	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8QJV20	GO:0032880	1/478	regulation of protein localization	biological_process	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]
EOG8QJV20	GO:0042059	1/478	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8QJV20	GO:0008302	1/478	female germline ring canal formation, actin assembly	biological_process	"Recruitment and organization of actin filaments in female germline ring canals." [ISBN:0879694238]
EOG8QJV20	GO:0030833	1/478	regulation of actin filament polymerization	biological_process	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG8QJV20	GO:0007619	1/478	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG8QJV20	GO:0030424	1/478	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8QJV20	GO:0008335	1/478	female germline ring canal stabilization	biological_process	"Maintenance of the structural integrity of the ring canals connecting the female germline cyst." [GOC:curators]
EOG8QJV20	GO:0030046	1/478	parallel actin filament bundle assembly	biological_process	"Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:mah, ISBN:0815316194]
EOG8QJV20	GO:0003402	1/478	planar cell polarity pathway involved in axis elongation	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8QJV20	GO:0008340	1/478	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8QJV20	GO:0045179	1/478	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8QJV20	GO:0005911	1/478	cell-cell junction	cellular_component	"A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah]
EOG8QJV20	GO:0030708	1/478	germarium-derived female germ-line cyst encapsulation	biological_process	"Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336]
EOG8QJV20	GO:0035014	1/478	phosphatidylinositol 3-kinase regulator activity	molecular_function	"Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates." [GOC:bf, PMID:9255069]
EOG8QJV20	GO:0036058	1/478	filtration diaphragm assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, PMID:18971929]
EOG8QJV20	GO:0007370	1/478	ventral furrow formation	biological_process	"Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238]
EOG8QJV20	GO:0046529	1/478	imaginal disc fusion, thorax closure	biological_process	"The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm]
EOG8QJV20	GO:0005942	1/478	phosphatidylinositol 3-kinase complex	cellular_component	"A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too." [GOC:bf, PMID:24587488]
EOG8QJV20	GO:0010669	1/478	epithelial structure maintenance	biological_process	"A tissue homeostatic process required for the maintenance of epithelial structure." [GOC:dph, GOC:tb]
EOG8QJV20	GO:0007395	1/478	dorsal closure, spreading of leading edge cells	biological_process	"Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa." [GOC:bf, PMID:12147138]
EOG8QJV20	GO:0031647	1/478	regulation of protein stability	biological_process	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]
EOG8QJV20	GO:0045197	1/478	establishment or maintenance of epithelial cell apical/basal polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]
EOG8QJV20	GO:0045860	1/478	positive regulation of protein kinase activity	biological_process	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
EOG8QJV20	GO:0046827	1/478	positive regulation of protein export from nucleus	biological_process	"Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf]
EOG8QJV20	GO:0007616	1/478	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8QJV20	GO:0034334	1/478	adherens junction maintenance	biological_process	"The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah]
EOG8QJV20	GO:0008355	1/478	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8QJV20	GO:0005927	1/478	muscle tendon junction	cellular_component	"A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007]
EOG8QJV20	GO:0016301	1/478	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8QJV20	GO:0007303	1/478	cytoplasmic transport, nurse cell to oocyte	biological_process	"The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238]
EOG8QJV20	GO:0044719	1/478	regulation of imaginal disc-derived wing size	biological_process	"Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
EOG8QJV20	GO:0007611	1/478	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG8QJV20	GO:0016199	1/478	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG8QJV20	GO:0007417	1/478	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8QJV20	GO:0003382	1/478	epithelial cell morphogenesis	biological_process	"The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8QJV20	GO:0043277	1/478	apoptotic cell clearance	biological_process	"The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684]
EOG8QJV20	GO:0005829	1/478	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8QJV20	GO:0043068	1/478	positive regulation of programmed cell death	biological_process	"Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
EOG8QJV20	GO:0007485	1/478	imaginal disc-derived male genitalia development	biological_process	"The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
EOG8QJV20	GO:0001764	1/478	neuron migration	biological_process	"The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]
EOG8QJV20	GO:0005938	1/478	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8QJV20	GO:0051017	1/478	actin filament bundle assembly	biological_process	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
EOG8QJV20	GO:0005886	1/478	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8QJV20	GO:0006099	1/478	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8QJV20	GO:0016477	1/478	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG8QJV20	GO:0016319	1/478	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8QJV20	GO:0008360	1/478	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8QJV20	GO:0002009	1/478	morphogenesis of an epithelium	biological_process	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
EOG8QJV20	GO:0008285	1/478	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8QJV20	GO:0008045	1/478	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8QJV20	GO:0007411	1/478	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8QJV20	GO:0050254	1/478	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8QJV20	GO:0019897	1/478	extrinsic component of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]
EOG8QJV20	GO:0045926	1/478	negative regulation of growth	biological_process	"Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
EOG8QJV20	GO:0042023	1/478	DNA endoreduplication	biological_process	"Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw]
EOG8QJV20	GO:0072499	1/478	photoreceptor cell axon guidance	biological_process	"The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
EOG8QJV20	GO:0007419	1/478	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8QJV20	GO:0008258	1/478	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8NKF92	GO:0005524	101/307	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8NKF92	GO:0005737	101/307	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8NKF92	GO:0005856	95/307	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8NKF92	GO:0007010	6/307	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8NKF92	GO:0005200	6/307	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8NKF92	GO:0005884	6/307	actin filament	cellular_component	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]
EOG8NKF92	GO:0000281	3/307	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8NKF92	GO:0005875	3/307	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8NKF92	GO:0006909	3/307	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8NKF92	GO:0005811	2/307	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8NKF92	GO:0031011	1/307	Ino80 complex	cellular_component	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820]
EOG8NKF92	GO:0002121	1/307	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8NKF92	GO:0016319	1/307	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8NKF92	GO:0051297	1/307	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8NKF92	GO:0007507	1/307	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8NKF92	GO:0014866	1/307	skeletal myofibril assembly	biological_process	"The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle]
EOG8NKF92	GO:0007291	1/307	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8NKF92	GO:0032507	1/307	maintenance of protein location in cell	biological_process	"Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah]
EOG8NKF92	GO:0051533	1/307	positive regulation of NFAT protein import into nucleus	biological_process	"Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai]
EOG8NKF93	GO:0005634	24/93	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NKF93	GO:0004402	2/93	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG80VZ5S	GO:0008270	28/58	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80VZ5S	GO:0016567	1/58	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG80VZ5S	GO:0016874	1/58	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8K6JJC	GO:0031514	1/86	motile cilium	cellular_component	"A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998]
EOG8K6JJC	GO:0046693	1/86	sperm storage	biological_process	"The retention of sperm by a female following mating." [PMID:10885514]
EOG8K6JJC	GO:0006629	1/86	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8K6JJC	GO:0007283	1/86	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8K6JJC	GO:0035556	1/86	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8K6JJC	GO:0004435	1/86	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8K6JJC	GO:0030154	1/86	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8K6JJC	GO:0030317	1/86	sperm motility	biological_process	"Any process involved in the controlled movement of a sperm cell." [GOC:jl]
EOG86DPGS	GO:0004725	29/119	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG86DPGS	GO:0008138	29/119	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG86DPGS	GO:0006470	1/119	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8T4G85	GO:0005737	12/117	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8T4G85	GO:0005634	11/117	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8T4G85	GO:0048489	1/117	synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr]
EOG8T4G85	GO:0005524	1/117	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8T4G85	GO:0000132	1/117	establishment of mitotic spindle orientation	biological_process	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
EOG8T4G85	GO:0016020	1/117	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8T4G85	GO:0042626	1/117	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8T4G85	GO:0048812	1/117	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8T4G85	GO:0008088	1/117	axon cargo transport	biological_process	"The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194]
EOG86DPGW	GO:0016021	1/88	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86DPGW	GO:0000902	1/88	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG86DPGW	GO:0005214	1/88	structural constituent of chitin-based cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8T4G86	GO:0005509	23/92	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8T4G86	GO:0008061	2/92	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8T4G86	GO:0005576	2/92	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8T4G86	GO:0006030	2/92	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8K6JJK	GO:0008168	24/87	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8K6JJK	GO:0003676	21/87	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K6JJK	GO:0006370	1/87	7-methylguanosine mRNA capping	biological_process	"Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685]
EOG8K6JJK	GO:0004483	1/87	mRNA (nucleoside-2'-O-)-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57]
EOG8K6JJK	GO:0005524	1/87	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8K6JJK	GO:0097309	1/87	cap1 mRNA methylation	biological_process	"Methylation of the ribose of the first nucleotide of a 5'-capped mRNA." [GOC:sp, PMID:20713356]
EOG8K6JJK	GO:0005634	1/87	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8K6JJK	GO:0080009	1/87	mRNA methylation	biological_process	"The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]
EOG80VZ5F	GO:0016887	2/21	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG80VZ5F	GO:0005215	2/21	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG80VZ5F	GO:0005524	2/21	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG80VZ5F	GO:0016021	2/21	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FFGGV	GO:0005739	1/77	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8FFGGV	GO:0006390	1/77	transcription from mitochondrial promoter	biological_process	"The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl]
EOG8T4G8B	GO:0051056	23/92	regulation of small GTPase mediated signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
EOG8T4G8B	GO:0005622	23/92	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8T4G8B	GO:0005096	23/92	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8T4G8B	GO:0035556	21/92	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8T4G8B	GO:0007165	2/92	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8T4G8B	GO:0007265	1/92	Ras protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf]
EOG8T4G8B	GO:0045678	1/92	positive regulation of R7 cell differentiation	biological_process	"Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8T4G8B	GO:0005886	1/92	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8T4G8B	GO:0007067	1/92	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8T4G8B	GO:0007426	1/92	tracheal outgrowth, open tracheal system	biological_process	"The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8T4G8B	GO:0031235	1/92	intrinsic component of the cytoplasmic side of the plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only." [GOC:dos, GOC:mah]
EOG8T4G8B	GO:0007062	1/92	sister chromatid cohesion	biological_process	"The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other." [GOC:jh, GOC:mah, ISBN:0815316194]
EOG8T4G8B	GO:0007476	1/92	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8T4G8B	GO:0046580	1/92	negative regulation of Ras protein signal transduction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
EOG8T4G8B	GO:0032320	1/92	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8T4G8B	GO:0022008	1/92	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8T4G8B	GO:0005099	1/92	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8T4G8B	GO:0046872	1/92	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8T4G8B	GO:0008595	1/92	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8T4G8B	GO:0005737	1/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8T4G8B	GO:0016321	1/92	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8T4G8B	GO:0008293	1/92	torso signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
EOG8T4G8G	GO:0005509	25/86	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8T4G8G	GO:0016021	23/86	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8T4G8G	GO:0007219	23/86	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8T4G8G	GO:0007275	22/86	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8T4G8G	GO:0016740	2/86	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8T4G8G	GO:0005112	1/86	Notch binding	molecular_function	"Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb]
EOG8T4G8G	GO:0042689	1/86	regulation of crystal cell differentiation	biological_process	"Any process that modulates the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]
EOG8T4G8G	GO:0046331	1/86	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8T4G8G	GO:0016324	1/86	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8T4G8G	GO:0035214	1/86	eye-antennal disc development	biological_process	"Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8T4G8G	GO:0007435	1/86	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8T4G8G	GO:0030718	1/86	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8T4G8G	GO:0005886	1/86	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8T4G8G	GO:0035017	1/86	cuticle pattern formation	biological_process	"The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf]
EOG8T4G8G	GO:0035170	1/86	lymph gland crystal cell differentiation	biological_process	"The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
EOG8T4G8G	GO:0042688	1/86	crystal cell differentiation	biological_process	"The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
EOG8T4G8G	GO:0007154	1/86	cell communication	biological_process	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]
EOG8T4G8G	GO:0048749	1/86	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8T4G8G	GO:0005515	1/86	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8T4G8G	GO:0005102	1/86	receptor binding	molecular_function	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]
EOG8T4G8G	GO:0016330	1/86	second mitotic wave involved in compound eye morphogenesis	biological_process	"A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224]
EOG8T4G8G	GO:0009986	1/86	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8T4G8G	GO:0007476	1/86	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8T4G8G	GO:0007431	1/86	salivary gland development	biological_process	"The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044]
EOG8T4G8G	GO:0030673	1/86	axolemma	cellular_component	"The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness." [http://www.medik.sk/clanky/bio_jun.htm, ISBN:0124325653]
EOG8T4G8G	GO:0036011	1/86	imaginal disc-derived leg segmentation	biological_process	"Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf]
EOG8T4G8G	GO:0007451	1/86	dorsal/ventral lineage restriction, imaginal disc	biological_process	"Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402]
EOG8T4G8G	GO:0035167	1/86	larval lymph gland hemopoiesis	biological_process	"The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385]
EOG8T4G8G	GO:0007423	1/86	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8T4G8G	GO:0014009	1/86	glial cell proliferation	biological_process	"The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585]
EOG8T4G8G	GO:0045746	1/86	negative regulation of Notch signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8T4G8G	GO:0007436	1/86	larval salivary gland morphogenesis	biological_process	"The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG80VZ54	GO:0005097	23/108	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG80VZ54	GO:0043195	1/108	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG80VZ54	GO:0031594	1/108	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8HB12K	GO:0003676	5/387	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HB12K	GO:0003723	1/387	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8HB12K	GO:0003964	1/387	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8HB12K	GO:0004842	1/387	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8T4G8R	GO:0015074	1/9	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8T4G8R	GO:0003964	1/9	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8T4G8R	GO:0003723	1/9	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8HB12C	GO:0005700	1/145	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8HB12C	GO:0044666	1/145	MLL3/4 complex	cellular_component	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]
EOG8HB12C	GO:0071557	1/145	histone H3-K27 demethylation	biological_process	"The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone." [GOC:sp, PMID:20023638]
EOG8HB12C	GO:0045746	1/145	negative regulation of Notch signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8HB12C	GO:1902465	1/145	negative regulation of histone H3-K27 trimethylation	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745]
EOG8HB12C	GO:0061086	1/145	negative regulation of histone H3-K27 methylation	biological_process	"Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb]
EOG8HB12C	GO:0042060	1/145	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8HB12C	GO:0045893	1/145	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8HB12C	GO:0045498	1/145	sex comb development	biological_process	"The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk]
EOG8HB12C	GO:0005705	1/145	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG8HB12C	GO:1990248	1/145	regulation of transcription from RNA polymerase II promoter in response to DNA damage	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:15660129]
EOG8HB12C	GO:0008168	1/145	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8HB12C	GO:0008285	1/145	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8HB12C	GO:0071390	1/145	cellular response to ecdysone	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah]
EOG8HB12C	GO:0035078	1/145	induction of programmed cell death by ecdysone	biological_process	"Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death." [GOC:bf]
EOG8HB12C	GO:0005515	1/145	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8HB12C	GO:0005634	1/145	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HB12C	GO:0016577	1/145	histone demethylation	biological_process	"The modification of histones by removal of methyl groups." [GOC:ai]
EOG8HB12C	GO:0010508	1/145	positive regulation of autophagy	biological_process	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8HB12C	GO:0001047	1/145	core promoter binding	molecular_function	"Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH]
EOG8HB12C	GO:0071480	1/145	cellular response to gamma radiation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah]
EOG8HB12C	GO:0051568	1/145	histone H3-K4 methylation	biological_process	"The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai]
EOG8HB12C	GO:0035072	1/145	ecdysone-mediated induction of salivary gland cell autophagic cell death	biological_process	"Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis." [GOC:bf]
EOG8FFGGN	GO:0003723	20/48	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8FFGGN	GO:0008168	18/48	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8W10T0	GO:0005509	4/72	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8P2SKR	GO:0006426	1/3	glycyl-tRNA aminoacylation	biological_process	"The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8P2SKR	GO:0004820	1/3	glycine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14]
EOG8P2SKR	GO:0005524	1/3	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8P2SKR	GO:0005737	1/3	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CG2QS	GO:0004657	3/7	proline dehydrogenase activity	molecular_function	"Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8]
EOG8CG2QS	GO:0006562	3/7	proline catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
EOG86MF2X	GO:0005634	1/6	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86MF2X	GO:0006351	1/6	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG86MF2X	GO:0003677	1/6	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86MF2X	GO:0005524	1/6	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG86MF2X	GO:0003700	1/6	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8TB6R8	GO:0006810	18/82	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8TB6R8	GO:0005643	18/82	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG8H1D99	GO:0004518	1/250	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8H1D99	GO:0004812	1/250	aminoacyl-tRNA ligase activity	molecular_function	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
EOG8H1D99	GO:0003677	1/250	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8PVRF3	GO:0005634	27/85	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PVRF3	GO:0006397	27/85	mRNA processing	biological_process	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]
EOG8PVRF3	GO:0004721	26/85	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8PVRF3	GO:0016791	1/85	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG8PVRF3	GO:0070940	1/85	dephosphorylation of RNA polymerase II C-terminal domain	biological_process	"The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form." [GOC:krc, GOC:mah, PMID:17079683]
EOG8PVRF3	GO:0008420	1/85	CTD phosphatase activity	molecular_function	"Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate." [EC:3.1.3.16]
EOG866Z10	GO:0016020	2/7	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG866Z10	GO:0004553	1/7	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG866Z10	GO:0017153	1/7	sodium:dicarboxylate symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]
EOG866Z10	GO:0003993	1/7	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG866Z10	GO:0005524	1/7	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG866Z10	GO:0005215	1/7	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG866Z10	GO:0006814	1/7	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG866Z10	GO:0005975	1/7	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG866Z16	GO:0016021	24/97	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG866Z16	GO:0005789	21/97	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG866Z16	GO:0008374	13/97	O-acyltransferase activity	molecular_function	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
EOG866Z16	GO:0004144	13/97	diacylglycerol O-acyltransferase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20]
EOG866Z16	GO:0019432	11/97	triglyceride biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]
EOG866Z16	GO:0010888	1/97	negative regulation of lipid storage	biological_process	"Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
EOG866Z16	GO:0035220	1/97	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG866Z16	GO:0048477	1/97	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG866Z16	GO:0045477	1/97	regulation of nurse cell apoptotic process	biological_process	"Any process that modulates the frequency, rate or extent of nurse cell apoptotic process." [GOC:mtg_apoptosis, PMID:11973306]
EOG866Z19	GO:0003682	19/93	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG866Z19	GO:0005634	9/93	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG866Z19	GO:0003677	7/93	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG866Z19	GO:0007379	2/93	segment specification	biological_process	"The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG866Z19	GO:0006355	2/93	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG866Z19	GO:0006351	2/93	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8642W1	GO:0045454	1/5	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8642W1	GO:0042302	1/5	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG86MF2D	GO:0046872	25/102	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG86MF2D	GO:0000166	25/102	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG86MF2D	GO:0003723	23/102	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG86MF2D	GO:0006397	20/102	mRNA processing	biological_process	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]
EOG86MF2D	GO:0003729	1/102	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG86MF2D	GO:0010628	1/102	positive regulation of gene expression	biological_process	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG86MF2D	GO:0046833	1/102	positive regulation of RNA export from nucleus	biological_process	"Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf]
EOG86MF2D	GO:1900364	1/102	negative regulation of mRNA polyadenylation	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841]
EOG86MF2D	GO:0045879	1/102	negative regulation of smoothened signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG86MF2D	GO:0005634	1/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85TG3Z	GO:0003676	6/36	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85TG3Z	GO:0003723	1/36	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG85TG3Z	GO:0003964	1/36	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG85TG3Z	GO:0004190	1/36	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8HQGZD	GO:0003755	1/39	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8HQGZD	GO:0006457	1/39	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8HQGZF	GO:0005875	1/51	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG870X0F	GO:0008138	25/72	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG870X0F	GO:0004725	24/72	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG870X0F	GO:0006470	2/72	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG85TG3S	GO:0007155	79/281	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG85TG3S	GO:0016021	77/281	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85TG3S	GO:0005764	5/281	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG85TG3S	GO:0004872	5/281	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG85TG3S	GO:0035071	2/281	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG85TG3S	GO:0048102	2/281	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG85TG3S	GO:0005886	1/281	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG85TG3S	GO:0005887	1/281	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85TG3S	GO:0016020	1/281	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG876NFT	GO:0003676	52/239	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG876NFT	GO:0046872	1/239	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG876NFT	GO:0005634	1/239	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG876NFT	GO:0003677	1/239	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG876NFQ	GO:0046331	1/84	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8QFZT6	GO:0005945	28/108	6-phosphofructokinase complex	cellular_component	"A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known." [GOC:mah, GOC:vw, ISBN:0198506732]
EOG8QFZT6	GO:0006096	28/108	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8QFZT6	GO:0003872	28/108	6-phosphofructokinase activity	molecular_function	"Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11]
EOG8QFZT6	GO:0006002	26/108	fructose 6-phosphate metabolic process	biological_process	"The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism." [ISBN:0198506732]
EOG8QFZT6	GO:0005524	25/108	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QFZT6	GO:0046872	1/108	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QFZT6	GO:0046835	1/108	carbohydrate phosphorylation	biological_process	"The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732]
EOG8HQGZR	GO:0031419	24/102	cobalamin binding	molecular_function	"Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah]
EOG8HQGZR	GO:0015889	24/102	cobalamin transport	biological_process	"The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8HQGZR	GO:0004047	1/102	aminomethyltransferase activity	molecular_function	"Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10]
EOG8HQGZR	GO:0005737	1/102	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HQGZR	GO:0003700	1/102	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8HQGZR	GO:0006546	1/102	glycine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]
EOG8HQGZR	GO:0006351	1/102	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8HQGZR	GO:0005634	1/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HQGZR	GO:0005576	1/102	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8HQGZR	GO:0003677	1/102	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8KD921	GO:0016021	48/108	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KD921	GO:0030054	47/108	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8KD921	GO:0045202	47/108	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8KD921	GO:0005230	47/108	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8KD921	GO:0005886	47/108	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8KD921	GO:0006811	2/108	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8KD921	GO:0006909	1/108	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8KD921	GO:0016020	1/108	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG876NFJ	GO:0005215	2/17	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG876NFJ	GO:0016020	1/17	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG876NFJ	GO:0016021	1/17	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG876NFH	GO:0004527	3/56	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8MGVPX	GO:0016772	2/9	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG89GNX4	GO:0016020	12/79	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG89GNX4	GO:0003824	11/79	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG89GNX4	GO:0008195	1/79	phosphatidate phosphatase activity	molecular_function	"Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [EC:3.1.3.4, GOC:pr]
EOG8NCPT8	GO:0015018	43/138	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135]
EOG8NCPT8	GO:0016020	41/138	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NCPT8	GO:0030166	2/138	proteoglycan biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]
EOG8NCPT8	GO:0006688	2/138	glycosphingolipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators]
EOG8NCPT8	GO:0016021	2/138	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NCPT8	GO:0046987	2/138	N-acetyllactosamine beta-1,3-glucuronosyltransferase activity	molecular_function	"Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)." [GOC:bf, PMID:12511570]
EOG8NCPT8	GO:0046872	2/138	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NCPT8	GO:0046988	2/138	asioloorosomucoid beta-1,3-glucuronosyltransferase activity	molecular_function	"Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid." [GOC:bf, PMID:12511570]
EOG8NCPT8	GO:0000139	2/138	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8NCPT8	GO:0009101	2/138	glycoprotein biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]
EOG8NCPT8	GO:0046989	2/138	galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity	molecular_function	"Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids." [GOC:bf, PMID:12511570]
EOG8NCPT8	GO:0006486	2/138	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8NCPT8	GO:0007422	1/138	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8MSGDB	GO:0016787	21/82	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8MSGDB	GO:0005840	4/82	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8MSGDB	GO:0003735	1/82	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8MSGDB	GO:0005762	1/82	mitochondrial large ribosomal subunit	cellular_component	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
EOG8NCPT4	GO:0034464	13/70	BBSome	cellular_component	"A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [GOC:BHF, PMID:17574030]
EOG8NCPT4	GO:0035058	13/70	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG8NCPT6	GO:0005509	23/97	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8MSGDT	GO:0004519	1/17	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8MSGDT	GO:0003964	1/17	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8X3KG1	GO:0043565	75/346	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8X3KG1	GO:0008270	75/346	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X3KG1	GO:0003700	74/346	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8X3KG1	GO:0005634	6/346	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X3KG1	GO:0006351	4/346	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8X3KG1	GO:0003707	3/346	steroid hormone receptor activity	molecular_function	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
EOG8X3KG1	GO:0006366	2/346	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8X3KG1	GO:0000981	2/346	RNA polymerase II transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
EOG8X3KG1	GO:0006357	1/346	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8X3KG1	GO:0001103	1/346	RNA polymerase II repressing transcription factor binding	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription." [GOC:txnOH]
EOG8X3KG1	GO:0030154	1/346	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8X3KG1	GO:0046982	1/346	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8X3KG1	GO:0005515	1/346	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8X3KG1	GO:0000122	1/346	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8X3KG1	GO:0061320	1/346	pericardial nephrocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]
EOG8X3KG1	GO:0060047	1/346	heart contraction	biological_process	"The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph]
EOG8X3KG1	GO:0007507	1/346	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8X3KG1	GO:0035050	1/346	embryonic heart tube development	biological_process	"The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
EOG8X3KG1	GO:0045944	1/346	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8X3KG1	GO:0001085	1/346	RNA polymerase II transcription factor binding	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II." [GOC:txnOH]
EOG8X3KG1	GO:0045893	1/346	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8X3KG1	GO:0009888	1/346	tissue development	biological_process	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]
EOG8X3KG1	GO:0035051	1/346	cardiocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf]
EOG8X3KG1	GO:0007398	1/346	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG8X3KG1	GO:0007389	1/346	pattern specification process	biological_process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
EOG8X3KG1	GO:0007350	1/346	blastoderm segmentation	biological_process	"The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8X3KG1	GO:0045892	1/346	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8X3KG1	GO:0048542	1/346	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG8X3KG1	GO:0022416	1/346	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8X3KG1	GO:0007510	1/346	cardioblast cell fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG8X3KG1	GO:0000983	1/346	transcription factor activity, RNA polymerase II core promoter sequence-specific	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
EOG8X3KG1	GO:0008407	1/346	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG8X3KG1	GO:0002805	1/346	regulation of antimicrobial peptide biosynthetic process	biological_process	"Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
EOG8X3KG1	GO:0009887	1/346	organ morphogenesis	biological_process	"Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]
EOG8X3KG1	GO:0007391	1/346	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8X3KG1	GO:0007179	1/346	transforming growth factor beta receptor signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
EOG8X3KG1	GO:0042440	1/346	pigment metabolic process	biological_process	"The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732]
EOG8X3KG1	GO:0008045	1/346	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8X3KG1	GO:0010002	1/346	cardioblast differentiation	biological_process	"The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG8KSS1K	GO:0003676	2/189	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KSS1K	GO:0015074	1/189	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG82NMG4	GO:0006412	26/112	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG82NMG4	GO:0003735	26/112	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG82NMG4	GO:0015935	25/112	small ribosomal subunit	cellular_component	"The smaller of the two subunits of a ribosome." [GOC:mah]
EOG82NMG4	GO:0005783	7/112	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG82NMG4	GO:0005840	2/112	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG82NMG4	GO:0051298	1/112	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG82NMG4	GO:0051297	1/112	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG89GNXV	GO:0003677	14/121	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG89GNXV	GO:0003899	14/121	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG89GNXV	GO:0006351	14/121	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8KSS18	GO:0005509	2/63	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8NCPTT	GO:0003676	13/210	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NCPTT	GO:0003677	8/210	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NCPTT	GO:0003964	1/210	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8NCPTT	GO:0003723	1/210	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG89GNXZ	GO:0016810	2/10	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
EOG89GNXZ	GO:0005524	2/10	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG89GNXZ	GO:0016887	2/10	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG89GNXZ	GO:0016020	1/10	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG89GNXZ	GO:0016021	1/10	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89GNXZ	GO:0008565	1/10	protein transporter activity	molecular_function	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
EOG89GNXZ	GO:0009306	1/10	protein secretion	biological_process	"The controlled release of proteins from a cell." [GOC:ai]
EOG89GNXZ	GO:0006807	1/10	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG89GNXZ	GO:0005215	1/10	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG89GNXZ	GO:0005886	1/10	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8X3KGN	GO:0008168	24/95	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8X3KGN	GO:0005739	1/95	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8X3KGN	GO:0043334	1/95	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	molecular_function	"Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048]
EOG8X3KGN	GO:0003838	1/95	sterol 24-C-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol." [EC:2.1.1.41]
EOG8X3KGN	GO:0006744	1/95	ubiquinone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]
EOG8X3KGK	GO:0003964	5/28	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8X3KGK	GO:0003723	5/28	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8X3KGK	GO:0046872	1/28	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZGRSF	GO:0004402	1/113	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8ZGRSF	GO:0042384	1/113	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8ZGRSF	GO:0005509	1/113	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8ZGRSF	GO:0031513	1/113	nonmotile primary cilium	cellular_component	"A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998]
EOG8ZGRSF	GO:0035058	1/113	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG8FN70Z	GO:0004089	28/206	carbonate dehydratase activity	molecular_function	"Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1]
EOG8FN70Z	GO:0008270	26/206	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FN70Z	GO:0005576	26/206	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8FN70Z	GO:0003964	2/206	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8FN70Z	GO:0003723	1/206	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8X3KGQ	GO:0005085	2/87	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8X3KGQ	GO:0008356	2/87	asymmetric cell division	biological_process	"The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
EOG8X3KGQ	GO:0005737	2/87	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8X3KGQ	GO:0007163	2/87	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8X3KGQ	GO:0050821	2/87	protein stabilization	biological_process	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]
EOG8X3KGQ	GO:0043087	2/87	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8X3KGQ	GO:0010004	2/87	gastrulation involving germ band extension	biological_process	"A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8X3KGQ	GO:0005938	2/87	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8X3KGQ	GO:0040001	2/87	establishment of mitotic spindle localization	biological_process	"The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai]
EOG8X3KGQ	GO:0055057	2/87	neuroblast division	biological_process	"The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron." [PMID:11163136, PMID:11250167]
EOG8X3KGQ	GO:0001965	2/87	G-protein alpha-subunit binding	molecular_function	"Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd]
EOG8X3KGQ	GO:0008105	2/87	asymmetric protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma]
EOG8X3KGQ	GO:0005829	1/87	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8X3KGQ	GO:0016998	1/87	cell wall macromolecule catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators]
EOG8HQH0R	GO:0030246	17/58	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8HQH0R	GO:0007399	1/58	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG80CM15	GO:0008270	3/14	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80CM15	GO:0003676	3/14	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8J3ZWS	GO:0000166	25/102	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8J3ZWS	GO:0003676	24/102	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8J3ZWS	GO:0003729	1/102	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8J3ZWS	GO:0016021	1/102	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NCPTB	GO:0016746	24/265	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8NCPTB	GO:0000502	4/265	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG8NCPTB	GO:0016021	2/265	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NCPTB	GO:0005838	1/265	proteasome regulatory particle	cellular_component	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]
EOG8NCPTB	GO:0006508	1/265	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8NCPTB	GO:0008541	1/265	proteasome regulatory particle, lid subcomplex	cellular_component	"The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb]
EOG8NCPTB	GO:0003735	1/265	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8NCPTB	GO:0005875	1/265	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8NCPTB	GO:0006412	1/265	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8NCPTB	GO:0005840	1/265	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8NCPTB	GO:0043161	1/265	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG8KD92F	GO:0046872	3/18	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8KD92F	GO:0003676	1/18	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KD92J	GO:0003824	2/167	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8KD92J	GO:0019898	1/167	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8KD92J	GO:0007561	1/167	imaginal disc eversion	biological_process	"The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317]
EOG85TG33	GO:0016021	49/151	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85TG33	GO:0006810	39/151	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG85TG33	GO:0006839	10/151	mitochondrial transport	biological_process	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]
EOG85TG33	GO:0031966	10/151	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG85TG33	GO:0005811	1/151	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG85TG33	GO:0005739	1/151	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG876NF1	GO:0050897	18/56	cobalt ion binding	molecular_function	"Interacting selectively and non-covalently with a cobalt (Co) ion." [GOC:ai]
EOG876NF1	GO:0004038	18/56	allantoinase activity	molecular_function	"Catalysis of the reaction: allantoin + H2O = allantoate." [EC:3.5.2.5]
EOG876NF1	GO:0000256	18/56	allantoin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684]
EOG876NF1	GO:0008270	18/56	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG876NF1	GO:0016888	3/56	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	molecular_function	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
EOG876NF1	GO:0016812	1/56	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]
EOG876NF1	GO:0016810	1/56	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
EOG870X01	GO:0051287	1/4	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG870X01	GO:0046168	1/4	glycerol-3-phosphate catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]
EOG870X01	GO:0005737	1/4	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG870X01	GO:0016616	1/4	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8KD92P	GO:0008270	28/88	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KD92P	GO:0005524	1/88	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KD92P	GO:0003676	1/88	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KD92P	GO:0004386	1/88	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8J13Q7	GO:0020037	23/84	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8J13Q7	GO:0005576	2/84	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8J13Q7	GO:0032440	1/84	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8HQGZ9	GO:0008270	38/100	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8HQGZ9	GO:0005886	4/100	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8HQGZ9	GO:0007164	4/100	establishment of tissue polarity	biological_process	"Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid]
EOG8HQGZ9	GO:0001736	4/100	establishment of planar polarity	biological_process	"Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
EOG8HQGZ9	GO:0009948	4/100	anterior/posterior axis specification	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8HQGZ9	GO:0016740	1/100	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8HQGZ9	GO:0016020	1/100	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HQGZ9	GO:0007163	1/100	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8HQGZ9	GO:0005515	1/100	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8HQGZ9	GO:0016348	1/100	imaginal disc-derived leg joint morphogenesis	biological_process	"The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8HQGZ9	GO:0045184	1/100	establishment of protein localization	biological_process	"The directed movement of a protein to a specific location." [GOC:bf]
EOG8HQGZ9	GO:0001737	1/100	establishment of imaginal disc-derived wing hair orientation	biological_process	"Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]
EOG8HQGZ9	GO:0070593	1/100	dendrite self-avoidance	biological_process	"The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551]
EOG8HQGZ9	GO:0005737	1/100	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HQGZ9	GO:0008104	1/100	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8HQGZ9	GO:0001738	1/100	morphogenesis of a polarized epithelium	biological_process	"The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]
EOG8HQGZ9	GO:0045746	1/100	negative regulation of Notch signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8HQGZ9	GO:0045185	1/100	maintenance of protein location	biological_process	"Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf]
EOG8HQGZ9	GO:0042067	1/100	establishment of ommatidial planar polarity	biological_process	"The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
EOG8ZKN12	GO:0005524	20/82	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZKN12	GO:0016887	20/82	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8B0152	GO:0004714	1/5	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG81ZHQW	GO:0016021	3/79	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81ZHQW	GO:0016787	1/79	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG81ZHQW	GO:0005634	1/79	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81ZHQW	GO:0000245	1/79	spliceosomal complex assembly	biological_process	"The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]
EOG81ZHQW	GO:0055085	1/79	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG81ZHQN	GO:0003777	54/190	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG81ZHQN	GO:0007018	54/190	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG81ZHQN	GO:0030286	48/190	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG81ZHQN	GO:0005524	48/190	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG81ZHQN	GO:0016887	45/190	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG81ZHQN	GO:0005875	2/190	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG81ZHQN	GO:0006200	2/190	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG81ZHQN	GO:0042623	2/190	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG81ZHQN	GO:0007605	1/190	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8BP3TD	GO:0046872	25/89	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8BP3TD	GO:0004462	25/89	lactoylglutathione lyase activity	molecular_function	"Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19072]
EOG8XKXRF	GO:0015930	1/2	glutamate synthase activity	molecular_function	"Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors." [EC:1.4.-.-]
EOG8XKXRF	GO:0006537	1/2	glutamate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
EOG83R626	GO:0004984	17/25	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG83R626	GO:0005549	17/25	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG83R626	GO:0016021	16/25	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83R626	GO:0004930	16/25	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG83R626	GO:0005886	13/25	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG83R626	GO:0050911	2/25	detection of chemical stimulus involved in sensory perception of smell	biological_process	"The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG83R626	GO:0016020	1/25	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XH2FH	GO:0042254	1/94	ribosome biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
EOG8XH2FH	GO:0007275	1/94	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8XH2FH	GO:0016055	1/94	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG8XH2FH	GO:0004930	1/94	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8XH2FH	GO:0005730	1/94	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8XH2FH	GO:0016021	1/94	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BS024	GO:0035091	7/41	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG8XH2H5	GO:0003964	8/565	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8XH2H5	GO:0003723	6/565	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8XH2H5	GO:0022857	1/565	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8XH2H5	GO:0016021	1/565	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WWV35	GO:0008080	1/2	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG8PP0WT	GO:0006886	29/133	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8PP0WT	GO:0008565	28/133	protein transporter activity	molecular_function	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
EOG8PP0WT	GO:0016192	28/133	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8PP0WT	GO:0005794	27/133	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8PP0WT	GO:0030131	27/133	clathrin adaptor complex	cellular_component	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]
EOG8PP0WT	GO:0008021	1/133	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8PP0WT	GO:0007269	1/133	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8PP0WT	GO:0030136	1/133	clathrin-coated vesicle	cellular_component	"A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]
EOG8PP0WT	GO:0005802	1/133	trans-Golgi network	cellular_component	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]
EOG8PP0WT	GO:0030117	1/133	membrane coat	cellular_component	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]
EOG8PP0WT	GO:0033363	1/133	secretory granule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]
EOG8PP0WT	GO:0006901	1/133	vesicle coating	biological_process	"A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid]
EOG8PP0WT	GO:0035652	1/133	cargo loading into clathrin-coated vesicle	biological_process	"Formation of a protein complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins that are going to be transported by a vesicle." [PMID:16162817]
EOG8PP0WT	GO:0030121	1/133	AP-1 adaptor complex	cellular_component	"A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499]
EOG8PP0WT	GO:0030135	1/133	coated vesicle	cellular_component	"Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]
EOG8PP0WT	GO:0048749	1/133	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8PP0WT	GO:0016183	1/133	synaptic vesicle coating	biological_process	"A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:curators, PMID:10099709]
EOG8PP0WT	GO:0055037	1/133	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG8PP0WT	GO:0030141	1/133	secretory granule	cellular_component	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732]
EOG8PRW7J	GO:0003677	7/55	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8PRW7J	GO:0006355	3/55	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8PRW7J	GO:0005634	3/55	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PRW7J	GO:0000785	3/55	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG8PRW7J	GO:0004525	1/55	ribonuclease III activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]
EOG8PRW7J	GO:0006396	1/55	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8PRW7J	GO:0003723	1/55	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG87H867	GO:0003723	6/322	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG87H867	GO:0003964	6/322	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG85MQKB	GO:0042048	1/105	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG85MQKB	GO:0002121	1/105	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG83FKC9	GO:0003676	1/13	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83FKC9	GO:0007218	1/13	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG83FKC5	GO:0004402	2/11	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8XH2F3	GO:0030529	2/89	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8XH2F3	GO:0019013	2/89	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8XH2F3	GO:0019843	1/89	rRNA binding	molecular_function	"Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl]
EOG8XH2F3	GO:0006364	1/89	rRNA processing	biological_process	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
EOG8XH2F3	GO:0005730	1/89	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8XH2F3	GO:0003723	1/89	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8XH2F0	GO:0019211	43/103	phosphatase activator activity	molecular_function	"Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]
EOG8XH2F0	GO:0003755	5/103	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8XH2F0	GO:0000413	3/103	protein peptidyl-prolyl isomerization	biological_process	"The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570]
EOG8XH2F0	GO:0008160	3/103	protein tyrosine phosphatase activator activity	molecular_function	"Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein." [GOC:ai, ISBN:0198506732]
EOG8XH2F0	GO:0005634	3/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XH2F0	GO:0030472	3/103	mitotic spindle organization in nucleus	biological_process	"A process resulting in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle in the nucleus. The process occurs during a mitotic cell cycle and takes place at the cellular level." [GOC:mah]
EOG8XH2F0	GO:0000159	3/103	protein phosphatase type 2A complex	cellular_component	"A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]
EOG8XH2F0	GO:0008601	3/103	protein phosphatase type 2A regulator activity	molecular_function	"Modulation of the activity of the enzyme protein phosphatase type 2A." [GOC:ai]
EOG8XH2F0	GO:0005737	3/103	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XH2F0	GO:0043085	2/103	positive regulation of catalytic activity	biological_process	"Any process that activates or increases the activity of an enzyme." [GOC:jl, GOC:tb]
EOG8XH2F0	GO:0050790	2/103	regulation of catalytic activity	biological_process	"Any process that modulates the activity of an enzyme." [GOC:ai]
EOG8XH2F0	GO:0032515	1/103	negative regulation of phosphoprotein phosphatase activity	biological_process	"Any process that stops or reduces the activity of a phosphoprotein phosphatase." [GOC:mah]
EOG8XH2F0	GO:0005524	1/103	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8XH2F0	GO:0042803	1/103	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8XH2F0	GO:0035307	1/103	positive regulation of protein dephosphorylation	biological_process	"Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]
EOG8XH2F0	GO:0051721	1/103	protein phosphatase 2A binding	molecular_function	"Interacting selectively and non-covalently with the enzyme protein phosphatase 2A." [GOC:ai]
EOG8XH2F0	GO:0043666	1/103	regulation of phosphoprotein phosphatase activity	biological_process	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]
EOG8XH2F0	GO:0006200	1/103	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8XH2F0	GO:0035308	1/103	negative regulation of protein dephosphorylation	biological_process	"Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]
EOG8XH2F0	GO:0032516	1/103	positive regulation of phosphoprotein phosphatase activity	biological_process	"Any process that activates or increases the activity of a phosphoprotein phosphatase." [GOC:mah]
EOG8T7BMM	GO:0005328	1/3	neurotransmitter:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
EOG8T7BMM	GO:0016021	1/3	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XD66V	GO:0003723	14/70	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8XD66V	GO:0009982	14/70	pseudouridine synthase activity	molecular_function	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]
EOG8XD66V	GO:0001522	14/70	pseudouridine synthesis	biological_process	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]
EOG8XD66V	GO:0003796	1/70	lysozyme activity	molecular_function	"Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17]
EOG8XD66W	GO:0016887	1/3	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8XD66W	GO:0005524	1/3	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8BP3T3	GO:0003677	23/173	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8BP3T3	GO:0003676	12/173	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BP3T3	GO:0008270	6/173	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BP3T3	GO:0005634	3/173	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BP3T3	GO:0046872	1/173	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8BP3T3	GO:0035556	1/173	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8QZB1T	GO:0003824	11/66	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8QZB1T	GO:0009063	8/66	cellular amino acid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]
EOG8QZB1T	GO:0007165	1/66	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG81RSBN	GO:0008270	22/85	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81RSBN	GO:0003723	2/85	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG81RSBN	GO:0003964	2/85	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG81RSBN	GO:0035556	1/85	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG81RSBN	GO:0046872	1/85	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZKN1R	GO:0016616	2/18	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8ZKN1R	GO:0005975	2/18	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8ZKN1R	GO:0016615	1/18	malate dehydrogenase activity	molecular_function	"Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]
EOG8ZKN1R	GO:0006108	1/18	malate metabolic process	biological_process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]
EOG8ZKN1X	GO:0006807	72/199	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG8ZKN1X	GO:0016811	72/199	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]
EOG8ZKN1X	GO:0004435	2/199	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8ZKN1X	GO:0035556	2/199	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8ZKN1X	GO:0006629	2/199	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8ZKN1X	GO:0071110	1/199	histone biotinylation	biological_process	"The modification of a histone by the addition of a biotinyl group." [GOC:rph, PMID:14613969, PMID:19019041]
EOG8ZKN1X	GO:0019898	1/199	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8ZKN1X	GO:0016787	1/199	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8ZKN1X	GO:0009408	1/199	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8ZKN1X	GO:0017159	1/199	pantetheine hydrolase activity	molecular_function	"Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine." [EC:3.5.1.92, RHEA:13448]
EOG8ZKN1X	GO:0018054	1/199	peptidyl-lysine biotinylation	biological_process	"The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117]
EOG8QZB29	GO:0000062	23/79	fatty-acyl-CoA binding	molecular_function	"Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732]
EOG8ZKN1C	GO:0005524	11/50	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZKN1C	GO:0017111	9/50	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8ZKN1C	GO:0004622	1/50	lysophospholipase activity	molecular_function	"Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5]
EOG8QZB24	GO:0005272	158/406	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8QZB24	GO:0016021	144/406	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QZB24	GO:0016020	15/406	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QZB24	GO:0003964	2/406	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8QZB24	GO:0003723	2/406	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8QZB24	GO:0007638	1/406	mechanosensory behavior	biological_process	"Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators]
EOG8QZB24	GO:0043022	1/406	ribosome binding	molecular_function	"Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators]
EOG8QZB24	GO:0050975	1/406	sensory perception of touch	biological_process	"The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]
EOG8QZB24	GO:0050966	1/406	detection of mechanical stimulus involved in sensory perception of pain	biological_process	"The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
EOG8QZB24	GO:0044736	1/406	acid-sensing ion channel activity	molecular_function	"Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when a an extracellular proton has been bound by the channel complex." [GOC:jl]
EOG8QZB24	GO:0030425	1/406	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8QZB24	GO:0048266	1/406	behavioral response to pain	biological_process	"Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid]
EOG8QZB24	GO:0008345	1/406	larval locomotory behavior	biological_process	"Locomotory behavior in a larval (immature) organism." [GOC:ai]
EOG8QZB24	GO:0043025	1/406	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8QZB24	GO:0042256	1/406	mature ribosome assembly	biological_process	"The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome." [GOC:ma]
EOG8QZB24	GO:0035725	1/406	sodium ion transmembrane transport	biological_process	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
EOG8QZB24	GO:0030424	1/406	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8QZB23	GO:0016301	4/94	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8QZB23	GO:0016740	1/94	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8QZB23	GO:0035090	1/94	maintenance of apical/basal cell polarity	biological_process	"Retaining the established polarization of a cell along its apical/basal axis." [GOC:bf]
EOG8QZB23	GO:0070050	1/94	neuron cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah]
EOG8QZB23	GO:0006974	1/94	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8XPSVV	GO:0007018	3/12	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8XPSVV	GO:0005930	3/12	axoneme	cellular_component	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]
EOG8XPSVV	GO:0003777	3/12	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8CVJQZ	GO:0003677	3/9	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CVJQX	GO:0005634	1/83	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CVJQX	GO:0000981	1/83	RNA polymerase II transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
EOG8CVJQX	GO:0007522	1/83	visceral muscle development	biological_process	"The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators]
EOG8CVJQX	GO:0006366	1/83	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8CVJQX	GO:0009186	1/83	deoxyribonucleoside diphosphate metabolic process	biological_process	"The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
EOG8CVJQX	GO:0046982	1/83	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8CVJQX	GO:0045944	1/83	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8CVJQX	GO:0008270	1/83	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CVJQX	GO:0016491	1/83	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8XPSVP	GO:0005524	26/106	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8XPSVP	GO:0004525	25/106	ribonuclease III activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]
EOG8XPSVP	GO:0006396	24/106	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8XPSVP	GO:0003723	24/106	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8XPSVP	GO:0008026	23/106	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8XPSVP	GO:0004386	4/106	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8XPSVP	GO:0003677	3/106	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XPSVP	GO:0016075	3/106	rRNA catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai]
EOG8XPSVP	GO:0003676	2/106	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XPSVP	GO:0016891	2/106	endoribonuclease activity, producing 5'-phosphomonoesters	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
EOG8XPSVP	GO:0002230	1/106	positive regulation of defense response to virus by host	biological_process	"Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
EOG8XPSVP	GO:0016442	1/106	RISC complex	cellular_component	"A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]
EOG8XPSVP	GO:0005515	1/106	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8XPSVP	GO:0005634	1/106	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XPSVP	GO:0070868	1/106	heterochromatin organization involved in chromatin silencing	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah]
EOG8XPSVP	GO:0006342	1/106	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG8XPSVP	GO:0035087	1/106	siRNA loading onto RISC involved in RNA interference	biological_process	"The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference." [GOC:bf, GOC:mah, PMID:14512631]
EOG8XPSVP	GO:0030422	1/106	production of siRNA involved in RNA interference	biological_process	"Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674]
EOG8XPSVP	GO:0016887	1/106	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8XPSVP	GO:0006200	1/106	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8XPSVP	GO:0033227	1/106	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8XPSVP	GO:0051607	1/106	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG8XPSVP	GO:0005737	1/106	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XPSVP	GO:0009047	1/106	dosage compensation by hyperactivation of X chromosome	biological_process	"Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577]
EOG8XPSVP	GO:0030423	1/106	targeting of mRNA for destruction involved in RNA interference	biological_process	"The process in which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674]
EOG8XPSVP	GO:0035197	1/106	siRNA binding	molecular_function	"Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme." [PMID:15066275, PMID:15066283]
EOG8XPSVP	GO:0006379	1/106	mRNA cleavage	biological_process	"Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah]
EOG8XPSVP	GO:0007626	1/106	locomotory behavior	biological_process	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
EOG8XPSVP	GO:0003725	1/106	double-stranded RNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]
EOG8XPSVP	GO:0016246	1/106	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG8XPSVP	GO:0009597	1/106	detection of virus	biological_process	"The series of events in which a stimulus from a virus is received and converted into a molecular signal." [GOC:hb]
EOG8CVJQV	GO:0016020	1/24	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CVJQV	GO:0005215	1/24	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG86T5F9	GO:0044666	1/113	MLL3/4 complex	cellular_component	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]
EOG86T5F9	GO:0003682	1/113	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG86T5F9	GO:0048188	1/113	Set1C/COMPASS complex	cellular_component	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]
EOG86T5F9	GO:0005515	1/113	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG86T5F9	GO:0045927	1/113	positive regulation of growth	biological_process	"Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
EOG86T5F9	GO:0045893	1/113	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG86T5F9	GO:0043966	1/113	histone H3 acetylation	biological_process	"The modification of histone H3 by the addition of an acetyl group." [GOC:jl]
EOG86T5F9	GO:0007049	1/113	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG86T5F9	GO:0005634	1/113	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86T5F9	GO:0051568	1/113	histone H3-K4 methylation	biological_process	"The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai]
EOG86T5F9	GO:0006338	1/113	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG86T5F9	GO:0043967	1/113	histone H4 acetylation	biological_process	"The modification of histone H4 by the addition of an acetyl group." [GOC:jl]
EOG86T5F9	GO:0000123	1/113	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG86T5F9	GO:0016573	1/113	histone acetylation	biological_process	"The modification of a histone by the addition of an acetyl group." [GOC:ai]
EOG86T5F9	GO:0003713	1/113	transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8SJ7TK	GO:0034088	9/94	maintenance of mitotic sister chromatid cohesion	biological_process	"The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah]
EOG8SJ7TK	GO:0032116	9/94	SMC loading complex	cellular_component	"A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved." [GOC:curators, GOC:vw, PMID:10882066]
EOG8SJ7TK	GO:0070193	1/94	synaptonemal complex organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis." [GOC:mah]
EOG8SJ7TK	GO:0035327	1/94	transcriptionally active chromatin	cellular_component	"The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872]
EOG8SJ7TK	GO:0045893	1/94	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8SJ7TK	GO:0006351	1/94	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8SJ7TK	GO:0005700	1/94	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8SJ7TK	GO:0007064	1/94	mitotic sister chromatid cohesion	biological_process	"The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866]
EOG8SJ7TK	GO:0016787	1/94	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8SJ7TK	GO:0005634	1/94	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SJ7TK	GO:0071733	1/94	transcriptional activation by promoter-enhancer looping	biological_process	"The formation and maintenance of DNA loops that juxtapose the promoter and enhancer regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter." [GOC:mah, PMID:15060134, PMID:19923429]
EOG8SJ7TK	GO:0005515	1/94	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8SJ7TK	GO:0043234	1/94	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8SJ7TK	GO:0006355	1/94	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8SJ7TK	GO:0005654	1/94	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG8SJ7TK	GO:0010628	1/94	positive regulation of gene expression	biological_process	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG84TRQ7	GO:0048812	1/94	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG86X1Q1	GO:0006516	22/86	glycoprotein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]
EOG86X1Q1	GO:0005737	22/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86X1Q1	GO:0005634	11/86	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86X1Q1	GO:0003684	11/86	damaged DNA binding	molecular_function	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
EOG86X1Q1	GO:0006289	11/86	nucleotide-excision repair	biological_process	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]
EOG86X1Q1	GO:0046872	2/86	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG86X1Q1	GO:0016787	1/86	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG86X1Q1	GO:0030246	1/86	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG86X1Q1	GO:0005829	1/86	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG86X1Q1	GO:0000224	1/86	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	molecular_function	"Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52]
EOG85XBB9	GO:0030036	3/25	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8CVJMV	GO:0000166	3/103	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8CVJMV	GO:0003676	3/103	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CVJMV	GO:0051301	3/103	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8CVJMV	GO:0045842	1/103	positive regulation of mitotic metaphase/anaphase transition	biological_process	"Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
EOG8CVJMV	GO:0000398	1/103	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8CVJMV	GO:0005634	1/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CVJMV	GO:0008054	1/103	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation	biological_process	"The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions via the negative regulation of a cyclin-dependent kinase." [GOC:mah, PMID:15840442]
EOG8CVJMV	GO:0090302	1/103	APC-Cdc20 complex activity	molecular_function	"A ubiquitin-protein ligase activity that increases the rate or extent of the metaphase to anaphase transition of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
EOG8CVJMV	GO:0009987	1/103	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8CVJMV	GO:0005680	1/103	anaphase-promoting complex	cellular_component	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]
EOG8CVJMV	GO:0071011	1/103	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8CVJMV	GO:0000278	1/103	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8CVJMV	GO:0022008	1/103	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8CVJMV	GO:0007067	1/103	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8Q2GVQ	GO:0046872	9/62	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Q2GVQ	GO:0003676	5/62	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FR37N	GO:0005615	1/56	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8FR37N	GO:0007166	1/56	cell surface receptor signaling pathway	biological_process	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
EOG8FR37N	GO:0048018	1/56	receptor agonist activity	molecular_function	"Interacts with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb, ISBN:0198506732]
EOG8FR37N	GO:2000252	1/56	negative regulation of feeding behavior	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." [GOC:obol]
EOG8FR37N	GO:0005576	1/56	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Q2GVX	GO:0006629	59/262	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8Q2GVX	GO:0016788	45/262	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG8Q2GVX	GO:0016298	13/262	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG8Q2GVX	GO:0004197	2/262	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8Q2GVX	GO:0004622	1/262	lysophospholipase activity	molecular_function	"Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5]
EOG8Q2GVX	GO:0006909	1/262	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG822D0H	GO:0005415	1/8	nucleoside:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)." [GOC:ai]
EOG822D0H	GO:0009244	1/8	lipopolysaccharide core region biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues." [ISBN:0198506732]
EOG822D0H	GO:0016021	1/8	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG822D0H	GO:0016746	1/8	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8Q2GVB	GO:0003951	28/113	NAD+ kinase activity	molecular_function	"Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632]
EOG8Q2GVB	GO:0007205	28/113	protein kinase C-activating G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]
EOG8Q2GVB	GO:0004143	28/113	diacylglycerol kinase activity	molecular_function	"Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh]
EOG8Q2GVB	GO:0035556	20/113	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8Q2GVB	GO:0005524	19/113	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8Q2GVB	GO:0005737	8/113	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Q2GVB	GO:0005768	8/113	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG8Q2GVB	GO:0051259	8/113	protein oligomerization	biological_process	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
EOG8Q2GVB	GO:0046872	8/113	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Q2GVB	GO:0016301	1/113	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8Q2GVB	GO:0016310	1/113	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG8Q2GVH	GO:0005524	16/82	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8Q2GVH	GO:0005634	10/82	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Q2GVH	GO:0051731	1/82	polynucleotide 5'-hydroxyl-kinase activity	molecular_function	"Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78]
EOG8Q2GVH	GO:0006364	1/82	rRNA processing	biological_process	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
EOG8Q2GVH	GO:0005730	1/82	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG83XXJ2	GO:0003743	25/94	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG83XXJ2	GO:0005852	25/94	eukaryotic translation initiation factor 3 complex	cellular_component	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]
EOG83XXJ2	GO:0033290	24/94	eukaryotic 48S preinitiation complex	cellular_component	"A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049]
EOG83XXJ2	GO:0016282	24/94	eukaryotic 43S preinitiation complex	cellular_component	"A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049]
EOG83XXJ2	GO:0001731	24/94	formation of translation preinitiation complex	biological_process	"The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd]
EOG83XXJ2	GO:0006446	24/94	regulation of translational initiation	biological_process	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG83XXJ2	GO:0009306	12/94	protein secretion	biological_process	"The controlled release of proteins from a cell." [GOC:ai]
EOG83XXJ2	GO:0003824	12/94	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG83XXJ2	GO:0005794	12/94	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG83XXJ2	GO:0007030	1/94	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG83XXJ2	GO:0005875	1/94	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG83XXJ2	GO:0070865	1/94	investment cone	cellular_component	"A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization." [GOC:sart, PMID:15829565, PMID:9550716]
EOG83XXJ2	GO:0002183	1/94	cytoplasmic translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]
EOG83XXJ2	GO:0043293	1/94	apoptosome	cellular_component	"A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms." [GOC:mtg_apoptosis, PMID:10428850, PMID:11406413, PMID:12176339, PMID:15189137]
EOG83XXJ2	GO:0005829	1/94	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG83XXJ2	GO:0048812	1/94	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG83XXJ2	GO:2001272	1/94	positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	biological_process	"Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis." [GOC:mtg_apoptosis]
EOG83XXJ2	GO:2001233	1/94	regulation of apoptotic signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]
EOG83XXJ2	GO:0007291	1/94	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG83XXJ2	GO:0097202	1/94	activation of cysteine-type endopeptidase activity	biological_process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:21726810]
EOG8616HZ	GO:0007155	51/345	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8616HZ	GO:0005524	32/345	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8616HZ	GO:0004672	17/345	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8616HZ	GO:0004713	14/345	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8616HZ	GO:0004714	7/345	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8616HZ	GO:0004715	1/345	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8616HZ	GO:0007169	1/345	transmembrane receptor protein tyrosine kinase signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
EOG8616HZ	GO:0006468	1/345	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8616HZ	GO:0018108	1/345	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG8616HZ	GO:0016020	1/345	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG800400	GO:0046331	2/92	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG800400	GO:0006816	2/92	calcium ion transport	biological_process	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG800400	GO:0005262	2/92	calcium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG800400	GO:0005764	2/92	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG800400	GO:0044130	2/92	negative regulation of growth of symbiont in host	biological_process	"Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
EOG800400	GO:0006914	2/92	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG800400	GO:0006874	2/92	cellular calcium ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah]
EOG800400	GO:0032008	2/92	positive regulation of TOR signaling	biological_process	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG800400	GO:0070588	2/92	calcium ion transmembrane transport	biological_process	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG800400	GO:0005765	2/92	lysosomal membrane	cellular_component	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]
EOG800400	GO:0000046	2/92	autophagosome maturation	biological_process	"The process in which autophagosomes, double-membraned vacuoles containing cytoplasmic material fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [GOC:autophagy, GOC:lf, PMID:11099404, PMID:16874026, PMID:17534139]
EOG800400	GO:0031902	2/92	late endosome membrane	cellular_component	"The lipid bilayer surrounding a late endosome." [GOC:pz]
EOG8FBM6Z	GO:0048489	1/53	synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr]
EOG8FBM6Z	GO:0007269	1/53	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8FBM6Z	GO:0009612	1/53	response to mechanical stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]
EOG8FBM6Z	GO:0030139	1/53	endocytic vesicle	cellular_component	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]
EOG8FBM6Z	GO:0007629	1/53	flight behavior	biological_process	"The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
EOG8FBM6Z	GO:0048488	1/53	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8FBM6Z	GO:0008021	1/53	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8FBM6Z	GO:0016079	1/53	synaptic vesicle exocytosis	biological_process	"Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
EOG8FBM6Z	GO:0030054	1/53	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8FBM6Z	GO:0005515	1/53	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FBM6V	GO:0004519	14/108	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8FBM6V	GO:0003964	14/108	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8FBM6V	GO:0006629	14/108	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8FBM6V	GO:0004435	13/108	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8FBM6V	GO:0004871	11/108	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8FBM6V	GO:0035556	9/108	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8FBM6V	GO:0005509	9/108	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8FBM6V	GO:0007264	8/108	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8FBM6V	GO:0005622	8/108	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8FBM6V	GO:0005085	8/108	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8FBM6V	GO:0003723	2/108	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8FBM6V	GO:0008081	1/108	phosphoric diester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]
EOG822D01	GO:0005634	24/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG822D01	GO:0022008	1/88	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG822D01	GO:0045454	1/88	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8D81KZ	GO:0003700	12/70	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8D81KZ	GO:0003707	12/70	steroid hormone receptor activity	molecular_function	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
EOG8D81KZ	GO:0006351	12/70	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8D81KZ	GO:0005634	12/70	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D81KZ	GO:0008270	10/70	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D81KZ	GO:0043565	10/70	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8D81KZ	GO:0003677	2/70	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8VMHZ7	GO:0016021	18/82	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VMHZ7	GO:0016020	6/82	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8VMHZ7	GO:0035208	1/82	positive regulation of hemocyte proliferation	biological_process	"Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8FR371	GO:0003677	1/3	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FR371	GO:0016021	1/3	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FR371	GO:0000156	1/3	phosphorelay response regulator activity	molecular_function	"Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140]
EOG8VDSCH	GO:0005524	25/90	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VDSCH	GO:0004672	24/90	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8VDSCH	GO:0016772	1/90	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8VDSCH	GO:0032504	1/90	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG85XBBC	GO:0003824	4/53	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8CVJQ7	GO:0016021	1/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CVJQ7	GO:0055085	1/6	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8CVJQ4	GO:0030314	1/110	junctional membrane complex	cellular_component	"Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622]
EOG8D294P	GO:0016757	17/76	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8C2KT3	GO:0005249	3/5	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8C2KT3	GO:0008076	3/5	voltage-gated potassium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
EOG85XBBW	GO:0005615	3/136	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG84XMWJ	GO:0032258	25/117	CVT pathway	biological_process	"A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast." [PMID:12865942, PMID:15659643]
EOG84XMWJ	GO:0030242	25/117	pexophagy	biological_process	"The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions." [GOC:autophagy, PMID:10547367, PMID:20083110]
EOG84XMWJ	GO:0006914	8/117	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG84XMWJ	GO:0016236	1/117	macroautophagy	biological_process	"The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure.  Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464]
EOG84XMWJ	GO:0010506	1/117	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG84XMWJ	GO:0014067	1/117	negative regulation of phosphatidylinositol 3-kinase signaling	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef]
EOG84XMWJ	GO:0042060	1/117	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG84XMWJ	GO:0035069	1/117	larval midgut histolysis	biological_process	"The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683]
EOG84XMWK	GO:0007605	1/101	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG84XMWK	GO:0042384	1/101	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG84XMWK	GO:0035721	1/101	intraciliary retrograde transport	biological_process	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]
EOG84XMWK	GO:0035058	1/101	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG84XMWK	GO:0031513	1/101	nonmotile primary cilium	cellular_component	"A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998]
EOG84F8RB	GO:0003676	3/9	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84F8RB	GO:0003964	1/9	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG84F8RB	GO:0003723	1/9	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8BP3RN	GO:0035556	27/117	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8BP3RN	GO:0005509	26/117	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8BP3RN	GO:0004435	25/117	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8BP3RN	GO:0004871	23/117	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8BP3RN	GO:0016042	15/117	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8BP3RN	GO:0006629	11/117	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8BP3RN	GO:0007629	1/117	flight behavior	biological_process	"The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
EOG8BP3RN	GO:0008081	1/117	phosphoric diester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]
EOG8GQSKJ	GO:0006355	34/134	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8GQSKJ	GO:0003677	34/134	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GQSKJ	GO:0005634	25/134	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GQSKJ	GO:0046872	25/134	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GQSKJ	GO:0006351	25/134	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8GQSKJ	GO:0007275	24/134	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8GQSKJ	GO:0035288	1/134	anterior head segmentation	biological_process	"Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136]
EOG8GQSKJ	GO:0009608	1/134	response to symbiont	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732]
EOG8GQSKJ	GO:0007389	1/134	pattern specification process	biological_process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
EOG8GQSKJ	GO:0007474	1/134	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG8GQSKJ	GO:0035203	1/134	regulation of lamellocyte differentiation	biological_process	"Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104]
EOG8GQSKJ	GO:0045087	1/134	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8GQSKJ	GO:0042694	1/134	muscle cell fate specification	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators]
EOG8GQSKJ	GO:0035287	1/134	head segmentation	biological_process	"Partitioning the insect head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial)." [PMID:10477305, PMID:7915837]
EOG8GQSKJ	GO:0007526	1/134	larval somatic muscle development	biological_process	"The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG8GQSKJ	GO:0001700	1/134	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8GQSKJ	GO:0007350	1/134	blastoderm segmentation	biological_process	"The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8GQSKJ	GO:0048813	1/134	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8GQSKJ	GO:0046427	1/134	positive regulation of JAK-STAT cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG8GQSKJ	GO:0035291	1/134	specification of segmental identity, intercalary segment	biological_process	"The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437, PMID:10477305]
EOG8GQSKJ	GO:0007476	1/134	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8GQSKJ	GO:0035289	1/134	posterior head segmentation	biological_process	"Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136]
EOG8GQSKJ	GO:0016204	1/134	determination of muscle attachment site	biological_process	"The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete]
EOG8RR8Z8	GO:0006479	19/80	protein methylation	biological_process	"The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai]
EOG8RR8Z8	GO:0008168	19/80	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8RR8Z8	GO:0005737	4/80	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RR8Z8	GO:0008469	2/80	histone-arginine N-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine." [EC:2.1.1.125]
EOG8RR8Z8	GO:0008276	2/80	protein methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732]
EOG8RR8Z8	GO:0019919	1/80	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	biological_process	"The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine." [RESID:AA0068, RESID:AA0069]
EOG8RR8Z8	GO:0070611	1/80	histone methyltransferase activity (H3-R2 specific)	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to arginine at position 2 of histone H3." [EC:2.1.1.125, GOC:mah, PMID:17898714]
EOG8RR8Z8	GO:0034970	1/80	histone H3-R2 methylation	biological_process	"The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone." [GOC:mah]
EOG8RR8Z8	GO:0045893	1/80	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8RR8Z8	GO:0005829	1/80	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8RR8Z8	GO:0005634	1/80	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RR8Z8	GO:0016277	1/80	[myelin basic protein]-arginine N-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine." [EC:2.1.1.126]
EOG8RR8Z8	GO:0003713	1/80	transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8RR8Z8	GO:0035242	1/80	protein-arginine omega-N asymmetric methyltransferase activity	molecular_function	"Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues." [PMID:14705965, RESID:AA0068, RESID:AA0069]
EOG8GQSKR	GO:0005524	1/4	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8GQSKR	GO:0016887	1/4	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8X6FPC	GO:0003677	17/79	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8F4VS5	GO:0046872	24/87	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8F4VS5	GO:0003676	7/87	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8F4VS5	GO:0005634	1/87	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CJXX2	GO:0015171	28/98	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8CJXX2	GO:0016021	28/98	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CJXX2	GO:0003333	1/98	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG8CJXX1	GO:0004842	21/112	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8CJXX1	GO:0016874	1/112	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8CJXX1	GO:0040011	1/112	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG8CJXX1	GO:0042787	1/112	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological_process	"The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]
EOG8CJXX1	GO:0005938	1/112	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8CJXX1	GO:0007623	1/112	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG8CJXX1	GO:0048935	1/112	peripheral nervous system neuron development	biological_process	"The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh]
EOG8CJXX1	GO:0007616	1/112	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8CJXX1	GO:0005737	1/112	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CJXX1	GO:0005634	1/112	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CJXX1	GO:0048813	1/112	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8XKXN9	GO:0003677	21/102	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XKXN9	GO:0006351	21/102	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8XKXN9	GO:0005634	21/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XKXN9	GO:0046872	14/102	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XKXN9	GO:0006909	1/102	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8XKXN9	GO:0008157	1/102	protein phosphatase 1 binding	molecular_function	"Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl]
EOG8CG2PC	GO:0000775	2/95	chromosome, centromeric region	cellular_component	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
EOG8CG2PC	GO:0008104	1/95	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8CG2PC	GO:0007052	1/95	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8CG2PC	GO:0051257	1/95	meiotic spindle midzone assembly	biological_process	"The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis." [GOC:ai, GOC:expert_rg, GOC:tb]
EOG8CG2PC	GO:0016572	1/95	histone phosphorylation	biological_process	"The modification of histones by addition of phosphate groups." [GOC:ai]
EOG8CG2PC	GO:0022008	1/95	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8CG2PC	GO:0008356	1/95	asymmetric cell division	biological_process	"The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
EOG8CG2PC	GO:0051310	1/95	metaphase plate congression	biological_process	"The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ai]
EOG8CG2PC	GO:0051233	1/95	spindle midzone	cellular_component	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
EOG8CG2PC	GO:0032133	1/95	chromosome passenger complex	cellular_component	"A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910]
EOG8CG2PC	GO:0045132	1/95	meiotic chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah]
EOG8CG2PC	GO:0005515	1/95	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8CG2PC	GO:0005634	1/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CG2PC	GO:0010032	1/95	meiotic chromosome condensation	biological_process	"Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401]
EOG8CG2PC	GO:0005694	1/95	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8CG2PC	GO:0008017	1/95	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8CG2PC	GO:0007056	1/95	spindle assembly involved in female meiosis	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah]
EOG8CG2PC	GO:0007065	1/95	male meiosis sister chromatid cohesion	biological_process	"The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male." [GOC:ai]
EOG8P2SHD	GO:0006629	13/55	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8P2SHD	GO:0005576	11/55	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8P2SHD	GO:0004806	6/55	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG8P2SHD	GO:0016787	5/55	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8P2SHD	GO:0003824	2/55	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG82NMFK	GO:0043565	15/62	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG82NMFK	GO:0005634	15/62	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84QWF0	GO:0007010	23/89	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG84QWF0	GO:0051693	1/89	actin filament capping	biological_process	"The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]
EOG84QWF0	GO:0003746	1/89	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG84QWF0	GO:0003779	1/89	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG84QWF0	GO:0005737	1/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84QWF0	GO:0007300	1/89	ovarian nurse cell to oocyte transport	biological_process	"Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG84QWF0	GO:0005739	1/89	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG84QWF0	GO:0035317	1/89	imaginal disc-derived wing hair organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853]
EOG84QWF0	GO:0007015	1/89	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG82NMFD	GO:0048137	1/93	spermatocyte division	biological_process	"The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238]
EOG82NMFD	GO:0007283	1/93	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG82NMFD	GO:0007031	1/93	peroxisome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
EOG82NMFD	GO:0042760	1/93	very long-chain fatty acid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:go_curators]
EOG8XKXN2	GO:0005524	52/210	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8XKXN2	GO:0004713	50/210	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8XKXN2	GO:0004714	5/210	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8XKXN2	GO:0006468	3/210	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8XKXN2	GO:0018108	3/210	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG8XKXN2	GO:0007435	3/210	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8XKXN2	GO:0007165	2/210	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8XKXN2	GO:0016021	2/210	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XKXN2	GO:0016055	2/210	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG8XKXN2	GO:0005886	2/210	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8XKXN2	GO:0016204	2/210	determination of muscle attachment site	biological_process	"The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete]
EOG8XKXN2	GO:0007411	2/210	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8XKXN2	GO:0016203	2/210	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8XKXN2	GO:0016301	1/210	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8XKXN2	GO:0017147	1/210	Wnt-protein binding	molecular_function	"Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]
EOG8XKXN2	GO:0008355	1/210	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8XKXN2	GO:0007482	1/210	haltere development	biological_process	"The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net]
EOG8XKXN2	GO:0030424	1/210	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8XKXN2	GO:0016201	1/210	synaptic target inhibition	biological_process	"The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]
EOG8XKXN2	GO:0008045	1/210	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8XKXN2	GO:0046331	1/210	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8XKXN2	GO:0016199	1/210	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG8XKXN2	GO:0007611	1/210	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG8XKXN2	GO:0007613	1/210	memory	biological_process	"The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089]
EOG8XKXN7	GO:0016021	7/138	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XKXN7	GO:0055085	7/138	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8XKXN7	GO:0031410	1/138	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG8XKXN7	GO:0008643	1/138	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8XKXN7	GO:0015770	1/138	sucrose transport	biological_process	"The directed movement of sucrose into, out of or within a cell, or between cells by means of some agent such as a transporter or pore. Sucrose is the disaccharide fructofuranosyl-glucopyranoside." [GOC:ai]
EOG8XKXN7	GO:0045454	1/138	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8XKXN7	GO:0008515	1/138	sucrose transmembrane transporter activity	molecular_function	"Enables the transfer of sucrose from one side of the membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
EOG8XKXN7	GO:0045177	1/138	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG82NMFB	GO:0016020	9/123	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82NMFB	GO:0007157	1/123	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]
EOG8F4VSW	GO:0016021	252/803	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F4VSW	GO:0006633	246/803	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8F4VSW	GO:0016740	246/803	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8F4VSW	GO:0009922	7/803	fatty acid elongase activity	molecular_function	"Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb]
EOG8F4VSW	GO:0030497	7/803	fatty acid elongation	biological_process	"The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094]
EOG8F4VSW	GO:0022008	1/803	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8F4VSW	GO:0051225	1/803	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG8F4VSW	GO:0007112	1/803	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG8F4VSW	GO:0042761	1/803	very long-chain fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:go_curators]
EOG8F4VSW	GO:0007110	1/803	meiosis I cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8F4VSW	GO:0000915	1/803	actomyosin contractile ring assembly	biological_process	"The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
EOG8F4VSW	GO:0007111	1/803	meiosis II cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8F4VSW	GO:0030176	1/803	integral component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
EOG8F4VSW	GO:0000212	1/803	meiotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah]
EOG8P2SH4	GO:0008234	43/140	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8P2SH4	GO:0035071	1/140	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8P2SH4	GO:0005764	1/140	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8P2SH4	GO:0045169	1/140	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG8P2SH4	GO:0005524	1/140	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8P2SH4	GO:0007586	1/140	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG8P2SH4	GO:0048102	1/140	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8P2SH4	GO:0016021	1/140	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8P2SH4	GO:0042626	1/140	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8CG2P6	GO:0008340	1/81	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG84QWFM	GO:0006777	28/114	Mo-molybdopterin cofactor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473]
EOG84QWFM	GO:0051539	28/114	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG84QWFM	GO:0003824	28/114	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG84QWFM	GO:0046872	27/114	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84QWFM	GO:0019008	24/114	molybdopterin synthase complex	cellular_component	"A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772]
EOG84QWFM	GO:0005525	1/114	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG84QWFM	GO:0061597	1/114	cyclic pyranopterin monophosphate synthase activity	molecular_function	"Catalysis of the reaction GTP = cyclic pyranopterin phosphate + diphosphate." [EC:4.1.99.18, GOC:dph, PMID:18154309]
EOG87SVXD	GO:0008312	24/84	7S RNA binding	molecular_function	"Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]
EOG87SVXD	GO:0045900	24/84	negative regulation of translational elongation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators]
EOG87SVXD	GO:0006614	24/84	SRP-dependent cotranslational protein targeting to membrane	biological_process	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]
EOG87SVXD	GO:0005786	22/84	signal recognition particle, endoplasmic reticulum targeting	cellular_component	"A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732]
EOG87SVXD	GO:0048500	2/84	signal recognition particle	cellular_component	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]
EOG82NMF4	GO:0040007	42/147	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG82NMF4	GO:0005576	40/147	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG82NMF4	GO:0005615	3/147	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG82NMF4	GO:0005160	2/147	transforming growth factor beta receptor binding	molecular_function	"Interacting selectively and non-covalently with the transforming growth factor beta receptor." [GOC:ai]
EOG82NMF4	GO:0007274	1/147	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG82NMF4	GO:0001708	1/147	cell fate specification	biological_process	"The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators]
EOG82NMF4	GO:0045887	1/147	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG82NMF4	GO:0007528	1/147	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG82NMF4	GO:0046928	1/147	regulation of neurotransmitter secretion	biological_process	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
EOG82NMF4	GO:0046982	1/147	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG82NMF4	GO:0007474	1/147	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG82NMF4	GO:0030509	1/147	BMP signaling pathway	biological_process	"A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PR:000000034]
EOG82NMF4	GO:0009953	1/147	dorsal/ventral pattern formation	biological_process	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG82NMF4	GO:0010629	1/147	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG82NMF4	GO:0008406	1/147	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG82NMF4	GO:0008586	1/147	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG82NMF4	GO:0007502	1/147	digestive tract mesoderm development	biological_process	"The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism." [GOC:ai]
EOG82NMF4	GO:0007179	1/147	transforming growth factor beta receptor signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
EOG82NMF4	GO:0007391	1/147	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG82NMF4	GO:0035222	1/147	wing disc pattern formation	biological_process	"The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf]
EOG82NMF4	GO:0048636	1/147	positive regulation of muscle organ development	biological_process	"Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators]
EOG82NMF4	GO:0030707	1/147	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG82NMF4	GO:0007354	1/147	zygotic determination of anterior/posterior axis, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG82NMF4	GO:0007378	1/147	amnioserosa formation	biological_process	"Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift." [ISBN:08795694238]
EOG8XKXNC	GO:0006904	8/47	vesicle docking involved in exocytosis	biological_process	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]
EOG89KJ4C	GO:0016021	22/115	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89KJ4C	GO:0016192	21/115	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG89KJ4C	GO:0007269	1/115	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG89KJ4C	GO:1900073	1/115	regulation of neuromuscular synaptic transmission	biological_process	"Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
EOG89KJ4C	GO:0008021	1/115	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG89KJ4C	GO:0022008	1/115	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG89KJ4C	GO:0003735	1/115	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG89KJ4C	GO:0006412	1/115	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG89KJ4C	GO:0016079	1/115	synaptic vesicle exocytosis	biological_process	"Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
EOG89KJ4C	GO:0005524	1/115	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG89KJ4C	GO:0015935	1/115	small ribosomal subunit	cellular_component	"The smaller of the two subunits of a ribosome." [GOC:mah]
EOG89KJ4C	GO:0019843	1/115	rRNA binding	molecular_function	"Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl]
EOG89KJ4C	GO:0017111	1/115	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG89KJ4C	GO:0031594	1/115	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG89KJ4C	GO:0007163	1/115	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG89KJ4C	GO:0016082	1/115	synaptic vesicle priming	biological_process	"The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342]
EOG89KJ4C	GO:0007616	1/115	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG82NMF1	GO:0006457	36/136	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG82NMF1	GO:0046872	34/136	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82NMF1	GO:0009408	31/136	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG82NMF1	GO:0005524	31/136	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82NMF1	GO:0022008	1/136	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8F4VSZ	GO:0045454	14/94	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8F4VSG	GO:0016491	199/611	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8F4VSG	GO:0047886	2/611	farnesol dehydrogenase activity	molecular_function	"Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH." [EC:1.1.1.216, RHEA:14700]
EOG8F4VSG	GO:0004316	1/611	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
EOG8F4VSG	GO:0016063	1/611	rhodopsin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
EOG8F4VSG	GO:0022008	1/611	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG83JFM2	GO:0004788	25/87	thiamine diphosphokinase activity	molecular_function	"Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate." [EC:2.7.6.2]
EOG83JFM2	GO:0005524	25/87	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG83JFM2	GO:0009229	25/87	thiamine diphosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [CHEBI:45931, GOC:jl, ISBN:0140512713]
EOG83JFM2	GO:0006772	24/87	thiamine metabolic process	biological_process	"The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [CHEBI:18385, GOC:jl, ISBN:0198506732]
EOG83JFM2	GO:0016301	4/87	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG84QWFZ	GO:0003677	36/163	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TXF6V	GO:0008146	20/85	sulfotransferase activity	molecular_function	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]
EOG8TXF6V	GO:0016021	20/85	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TXF6V	GO:0016051	20/85	carbohydrate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]
EOG8CJXXM	GO:0006457	5/17	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8CJXXM	GO:0003755	5/17	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8CJXXM	GO:0006412	1/17	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8CJXXM	GO:0005840	1/17	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8CJXXM	GO:0003735	1/17	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8M680N	GO:0008270	24/84	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8M680N	GO:0003723	18/84	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8M680N	GO:0005634	18/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XKXNP	GO:0003676	1/23	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8R52GZ	GO:0003677	27/96	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8R52GZ	GO:0005664	27/96	nuclear origin of replication recognition complex	cellular_component	"A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh]
EOG8R52GZ	GO:0006260	27/96	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8R52GZ	GO:0051297	1/96	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8R52GZ	GO:0051298	1/96	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8R52GZ	GO:0007611	1/96	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG8R52GZ	GO:0007612	1/96	learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544]
EOG8R52GZ	GO:0006270	1/96	DNA replication initiation	biological_process	"The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194]
EOG8R52GZ	GO:0030536	1/96	larval feeding behavior	biological_process	"Feeding behavior in a larval (immature) organism." [GOC:mah]
EOG8R52GZ	GO:0007298	1/96	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8R52GZ	GO:0072686	1/96	mitotic spindle	cellular_component	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
EOG8R52GZ	GO:0008355	1/96	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8GJ24V	GO:0003723	3/39	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG84QWFT	GO:0004402	2/103	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG84QWFT	GO:0007362	1/103	terminal region determination	biological_process	"Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG84QWFT	GO:0016021	1/103	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84QWFT	GO:0007476	1/103	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG84QWFT	GO:0045892	1/103	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8PK4NW	GO:0016905	2/84	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG8RR8ZT	GO:0051539	23/91	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8RR8ZT	GO:0016020	23/91	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RR8ZT	GO:0016651	21/91	oxidoreductase activity, acting on NAD(P)H	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8RR8ZT	GO:0003954	2/91	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8RR8ZT	GO:0005739	1/91	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8F20HF	GO:0003677	1/114	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8284G8	GO:0016021	294/728	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8284G8	GO:0055085	283/728	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8284G8	GO:0005215	14/728	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8284G8	GO:0015114	10/728	phosphate ion transmembrane transporter activity	molecular_function	"Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai]
EOG8284G8	GO:0005886	2/728	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8284G8	GO:0006814	2/728	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8284G8	GO:0015293	2/728	symporter activity	molecular_function	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
EOG8284G8	GO:0005314	1/728	high-affinity glutamate transmembrane transporter activity	molecular_function	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.3.10.5]
EOG8284G8	GO:0015321	1/728	sodium-dependent phosphate transmembrane transporter activity	molecular_function	"Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions." [GOC:jl]
EOG8284G8	GO:0051938	1/728	L-glutamate import	biological_process	"The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah]
EOG8284G8	GO:0048190	1/728	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8284G8	GO:0006541	1/728	glutamine metabolic process	biological_process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
EOG8284G8	GO:0035725	1/728	sodium ion transmembrane transport	biological_process	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
EOG8284G8	GO:0001666	1/728	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG8284G8	GO:0007005	1/728	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8284G8	GO:0035435	1/728	phosphate ion transmembrane transport	biological_process	"The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
EOG8284G8	GO:0044341	1/728	sodium-dependent phosphate transport	biological_process	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl]
EOG8284G8	GO:0005436	1/728	sodium:phosphate symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai]
EOG8284G8	GO:0004930	1/728	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8GQSK8	GO:0003723	1/93	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8GJ22Z	GO:0046872	15/127	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GJ22Z	GO:0006886	15/127	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8GJ22Z	GO:0070073	1/127	clustering of voltage-gated calcium channels	biological_process	"The process in which voltage-gated calcium channels become localized together in high densities." [GOC:BHF, GOC:sart, PMID:18385325]
EOG8GJ22Z	GO:0048786	1/127	presynaptic active zone	cellular_component	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
EOG8GJ22Z	GO:0007269	1/127	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8GJ22Z	GO:0008021	1/127	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8GJ22Z	GO:0048167	1/127	regulation of synaptic plasticity	biological_process	"A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290]
EOG8GJ22Z	GO:0016079	1/127	synaptic vesicle exocytosis	biological_process	"Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
EOG8GJ22Z	GO:0007274	1/127	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8GJ22Z	GO:0016192	1/127	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8T4G91	GO:0005737	23/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8T4G91	GO:0004177	23/89	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG8T4G91	GO:0008235	23/89	metalloexopeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]
EOG8T4G91	GO:0030145	23/89	manganese ion binding	molecular_function	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
EOG8T4G91	GO:0008240	1/89	tripeptidyl-peptidase activity	molecular_function	"Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah]
EOG8T4G91	GO:0006508	1/89	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8T4G91	GO:0008239	1/89	dipeptidyl-peptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]
EOG8GQSK1	GO:0006511	26/93	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8GQSK1	GO:0004843	24/93	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG8GQSK1	GO:0008270	11/93	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GQSK1	GO:0008234	2/93	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8GQSK1	GO:0007399	1/93	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8GQSK1	GO:0016579	1/93	protein deubiquitination	biological_process	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]
EOG8T4G98	GO:0046872	7/51	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8T4G98	GO:0006886	6/51	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8PK4NN	GO:0004842	28/137	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8PK4NN	GO:0046872	18/137	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8PK4NN	GO:0020037	15/137	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8PK4NN	GO:0008270	5/137	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PK4NN	GO:0005814	1/137	centriole	cellular_component	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
EOG8PK4NN	GO:0005549	1/137	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8PK4NN	GO:0005737	1/137	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8PK4NN	GO:0005634	1/137	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PK4NN	GO:0042787	1/137	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological_process	"The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]
EOG8W6RB1	GO:0005524	2/61	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8W6RB1	GO:0008094	2/61	DNA-dependent ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl]
EOG8W6RB1	GO:0006259	2/61	DNA metabolic process	biological_process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]
EOG8W6RB1	GO:0003677	2/61	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8W6RB1	GO:0005789	1/61	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8W6RB1	GO:0016887	1/61	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8W6RB1	GO:0051726	1/61	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8W6RB1	GO:0006506	1/61	GPI anchor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
EOG82Z76F	GO:0006412	28/94	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG82Z76F	GO:0015934	28/94	large ribosomal subunit	cellular_component	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]
EOG82Z76F	GO:0003735	28/94	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG82Z76F	GO:0007052	1/94	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG82Z76F	GO:0000022	1/94	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG82Z76F	GO:0005840	1/94	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8TQPR7	GO:0016021	1/16	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TQPR7	GO:0005452	1/16	inorganic anion exchanger activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah]
EOG8ZW7VV	GO:0016791	1/2	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG8GJ24N	GO:0022008	1/165	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8X3KFJ	GO:0003968	1/92	RNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah]
EOG8HQH1K	GO:0006412	27/88	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8HQH1K	GO:0003735	27/88	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8HQH1K	GO:0005840	27/88	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8HQH1K	GO:0005730	1/88	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8HQH1K	GO:0000228	1/88	nuclear chromosome	cellular_component	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
EOG8HQH1K	GO:0005737	1/88	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8X3KFW	GO:0005524	27/97	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X3KFW	GO:0004674	25/97	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8X3KFW	GO:0004672	3/97	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8X3KFW	GO:0004712	2/97	protein serine/threonine/tyrosine kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]
EOG8X3KFW	GO:0016772	2/97	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8X3KFW	GO:0071011	1/97	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8X3KFW	GO:0022008	1/97	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8X3KFW	GO:0008360	1/97	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8X3KFW	GO:0000398	1/97	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8X3KFW	GO:0071013	1/97	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8X3KFW	GO:0006468	1/97	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8X3KFW	GO:0007155	1/97	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8X3KFR	GO:0006351	34/94	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8X3KFR	GO:0005634	34/94	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X3KFR	GO:0007275	32/94	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8X3KFR	GO:0003700	31/94	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8X3KFR	GO:0043565	30/94	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8X3KFR	GO:0003677	3/94	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X3KFR	GO:0006355	3/94	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8X3KFR	GO:0000122	2/94	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8X3KFR	GO:0048749	2/94	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8X3KFR	GO:0001654	1/94	eye development	biological_process	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
EOG8X3KFR	GO:0007435	1/94	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8X3KFR	GO:0007477	1/94	notum development	biological_process	"The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jid]
EOG8X3KFR	GO:0001745	1/94	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8X3KFR	GO:0035214	1/94	eye-antennal disc development	biological_process	"Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8X3KFR	GO:0007469	1/94	antennal development	biological_process	"The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526]
EOG8X3KFR	GO:0000977	1/94	RNA polymerase II regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
EOG89CSP6	GO:0050909	46/68	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG89CSP6	GO:0016021	46/68	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89CSP6	GO:0005886	46/68	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG89CSP6	GO:0008527	5/68	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG89CSP6	GO:0050912	5/68	detection of chemical stimulus involved in sensory perception of taste	biological_process	"The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG89CSP6	GO:0001580	1/68	detection of chemical stimulus involved in sensory perception of bitter taste	biological_process	"The series of events required for a bitter taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
EOG89CSP6	GO:0033041	1/68	sweet taste receptor activity	molecular_function	"Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah]
EOG89CSP6	GO:0050913	1/68	sensory perception of bitter taste	biological_process	"The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG89CSP6	GO:0050916	1/68	sensory perception of sweet taste	biological_process	"The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG89CSP6	GO:0033038	1/68	bitter taste receptor activity	molecular_function	"Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste." [GOC:mah]
EOG89CSP6	GO:0001582	1/68	detection of chemical stimulus involved in sensory perception of sweet taste	biological_process	"The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
EOG8Z6529	GO:0005509	18/118	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8Z6529	GO:0005576	11/118	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Z6529	GO:0030414	11/118	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8Z6529	GO:0051539	2/118	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8Z6529	GO:0008362	1/118	chitin-based embryonic cuticle biosynthetic process	biological_process	"Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232]
EOG8Z6529	GO:0007475	1/118	apposition of dorsal and ventral imaginal disc-derived wing surfaces	biological_process	"The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu]
EOG8Z6529	GO:0005201	1/118	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG8Z6529	GO:0031012	1/118	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8Z6529	GO:0040005	1/118	chitin-based cuticle attachment to epithelium	biological_process	"Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8Z6529	GO:0007424	1/118	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8Z6529	GO:0046331	1/118	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG87WR3Z	GO:0004364	77/178	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG87WR3Z	GO:0005737	76/178	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87WR3Z	GO:0016782	4/178	transferase activity, transferring sulfur-containing groups	molecular_function	"Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG87WR3Z	GO:0045174	4/178	glutathione dehydrogenase (ascorbate) activity	molecular_function	"Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [EC:1.8.5.1, RHEA:24427]
EOG87WR3Z	GO:0006749	4/178	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG87WR3Z	GO:0042803	1/178	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG87WR3Z	GO:0055114	1/178	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG87WR3Z	GO:0045454	1/178	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG87WR3Z	GO:0050829	1/178	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG87WR3Z	GO:0009055	1/178	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG87WR3Z	GO:0006726	1/178	eye pigment biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
EOG87WR3Z	GO:0045824	1/178	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG87WR3Z	GO:0004734	1/178	pyrimidodiazepine synthase activity	molecular_function	"Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1]
EOG87WR3Z	GO:0006728	1/178	pteridine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732]
EOG8KD91D	GO:0016020	8/65	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8KD91D	GO:0005524	8/65	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KD91D	GO:0016887	8/65	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8KD91C	GO:0080019	36/163	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8Z91D3	GO:0003676	5/104	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Z91D3	GO:0008270	5/104	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Z91D3	GO:0003723	1/104	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8Z91D3	GO:0004190	1/104	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8Z91D3	GO:0003964	1/104	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG87WR3S	GO:0004197	27/35	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG83V2B4	GO:0004871	1/74	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG83V2B4	GO:0006351	1/74	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG83V2B4	GO:0005509	1/74	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG83V2B4	GO:0005634	1/74	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83V2B4	GO:0003677	1/74	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG83V2B4	GO:0005737	1/74	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83V2B4	GO:0003700	1/74	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG82588D	GO:0070176	27/86	DRM complex	cellular_component	"A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification." [PMID:17075059]
EOG82588D	GO:0007049	27/86	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG82588D	GO:0006351	27/86	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG82588D	GO:0000791	1/86	euchromatin	cellular_component	"A dispersed and relatively uncompacted form of chromatin." [GOC:elh]
EOG82588D	GO:0048749	1/86	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG82588D	GO:0005700	1/86	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG82588D	GO:0031523	1/86	Myb complex	cellular_component	"A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624]
EOG82588D	GO:0000122	1/86	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG82588D	GO:0005634	1/86	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GMXDV	GO:0003841	1/5	1-acylglycerol-3-phosphate O-acyltransferase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51, GOC:ab]
EOG80P6QB	GO:0005856	1/66	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG80P6QB	GO:0009966	1/66	regulation of signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]
EOG80P6QB	GO:0008360	1/66	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG80P6QB	GO:0005198	1/66	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG80P6QB	GO:0005737	1/66	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG80P6QB	GO:0005886	1/66	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG87WR3B	GO:0008430	32/95	selenium binding	molecular_function	"Interacting selectively and non-covalently with selenium (Se)." [GOC:ai]
EOG87WR3G	GO:0044262	26/110	cellular carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
EOG87WR3G	GO:0004459	25/110	L-lactate dehydrogenase activity	molecular_function	"Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27, RHEA:23447]
EOG87WR3G	GO:0006096	24/110	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG87WR3G	GO:0005737	23/110	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87WR3G	GO:0006810	1/110	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG87WR3G	GO:0016021	1/110	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87WR3G	GO:0016616	1/110	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8KD91X	GO:0000022	1/80	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8S7N3S	GO:0003677	27/99	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8S7N3S	GO:0003899	27/99	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8S7N3S	GO:0005665	26/99	DNA-directed RNA polymerase II, core complex	cellular_component	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8S7N3S	GO:0006366	26/99	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8S7N3S	GO:0005700	1/99	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8S7N3S	GO:0006351	1/99	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8S7N3S	GO:0007095	1/99	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8S7N3S	GO:0005634	1/99	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8S7N3S	GO:0046872	1/99	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8S7N3S	GO:0005703	1/99	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG825881	GO:0003964	2/105	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG825881	GO:0003723	2/105	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG825880	GO:0004252	24/106	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG825880	GO:0008237	1/106	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG825880	GO:0016020	1/106	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG825880	GO:0008241	1/106	peptidyl-dipeptidase activity	molecular_function	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]
EOG825880	GO:0006508	1/106	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG825880	GO:0008233	1/106	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8RFP7R	GO:0009306	1/88	protein secretion	biological_process	"The controlled release of proteins from a cell." [GOC:ai]
EOG8RFP7R	GO:0000902	1/88	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8RFP7R	GO:0048812	1/88	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8TXF6F	GO:0016021	73/311	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TXF6F	GO:0055085	69/311	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8TXF6F	GO:0005432	3/311	calcium:sodium antiporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597]
EOG8TXF6F	GO:0003824	1/311	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8TXF6F	GO:0015293	1/311	symporter activity	molecular_function	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
EOG8TXF6F	GO:0005886	1/311	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8TXF6F	GO:0006816	1/311	calcium ion transport	biological_process	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8TXF6F	GO:0006814	1/311	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8TXF6F	GO:0008273	1/311	calcium, potassium:sodium antiporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1]
EOG8TXF6F	GO:0035725	1/311	sodium ion transmembrane transport	biological_process	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
EOG81VNGW	GO:0003824	17/89	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG81VNGW	GO:0016705	1/89	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG81VNGW	GO:0020037	1/89	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG81VNGW	GO:0005506	1/89	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG81VNGW	GO:0004619	1/89	phosphoglycerate mutase activity	molecular_function	"Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1]
EOG81VNGW	GO:0003677	1/89	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8KD917	GO:0016428	25/83	tRNA (cytosine-5-)-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine." [EC:2.1.1.29]
EOG8KD917	GO:0003723	20/83	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8KD917	GO:0005737	1/83	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8KD917	GO:0007614	1/83	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8KD917	GO:0000049	1/83	tRNA binding	molecular_function	"Interacting selectively and non-covalently with transfer RNA." [GOC:ai]
EOG8KD917	GO:0030488	1/83	tRNA methylation	biological_process	"The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]
EOG8KD917	GO:0005730	1/83	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8KD917	GO:0008168	1/83	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8GMXD3	GO:0016021	1/106	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z652K	GO:0005634	27/97	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z652K	GO:0007067	26/97	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8Z652K	GO:0000775	24/97	chromosome, centromeric region	cellular_component	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
EOG8Z652K	GO:0005737	3/97	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Z652K	GO:0007126	3/97	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8Z652K	GO:0000777	2/97	condensed chromosome kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG8Z652K	GO:0000070	1/97	mitotic sister chromatid segregation	biological_process	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
EOG8Z652K	GO:0000940	1/97	condensed chromosome outer kinetochore	cellular_component	"The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983]
EOG8Z652K	GO:0040020	1/97	regulation of meiotic nuclear division	biological_process	"Any process that modulates the frequency, rate or extent of meiosis, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma]
EOG8Z652K	GO:0000776	1/97	kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG8Z652K	GO:0007094	1/97	mitotic spindle assembly checkpoint	biological_process	"A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190]
EOG8Z652K	GO:0000278	1/97	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8Z652K	GO:0022008	1/97	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8Z652K	GO:0005828	1/97	kinetochore microtubule	cellular_component	"Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194]
EOG8Q87BF	GO:0007476	1/114	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8Q87BF	GO:0003676	1/114	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q87BF	GO:0008270	1/114	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q87BF	GO:0046872	1/114	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RFP7N	GO:0030246	26/95	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8KD911	GO:0052689	3/275	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG8KD911	GO:0007416	2/275	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG8KD911	GO:0016020	2/275	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8KD911	GO:0007155	2/275	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8KD911	GO:0004872	2/275	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8KD911	GO:0042043	2/275	neurexin family protein binding	molecular_function	"Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals." [GOC:curators, GOC:pr, PMID:18923512]
EOG8KD911	GO:0005887	2/275	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KD911	GO:0045202	2/275	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8KD911	GO:0009986	2/275	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8KD911	GO:0051932	1/275	synaptic transmission, GABAergic	biological_process	"The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [ISBN:0126603030]
EOG8KD911	GO:0006909	1/275	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8KD911	GO:0003990	1/275	acetylcholinesterase activity	molecular_function	"Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
EOG8KD911	GO:0022008	1/275	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8KD911	GO:0030431	1/275	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG83V2BC	GO:0043565	2/7	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG83V2BC	GO:0003676	1/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RFP7G	GO:0048102	1/21	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8RFP7G	GO:0035071	1/21	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8Z652D	GO:0000724	14/80	double-strand break repair via homologous recombination	biological_process	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]
EOG8Z652D	GO:0003697	13/80	single-stranded DNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174]
EOG8Z652G	GO:0008270	23/109	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Z652G	GO:0005622	5/109	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8Z652G	GO:0046716	1/109	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG8Z652G	GO:0030239	1/109	myofibril assembly	biological_process	"Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]
EOG8Z652G	GO:0048747	1/109	muscle fiber development	biological_process	"The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
EOG8Z652G	GO:0006941	1/109	striated muscle contraction	biological_process	"A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
EOG8Z652G	GO:0030018	1/109	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8KD918	GO:0016021	1/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KD918	GO:0000166	1/99	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8KD918	GO:0002121	1/99	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8KD918	GO:0019829	1/99	cation-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]
EOG8KD918	GO:0016363	1/99	nuclear matrix	cellular_component	"The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]
EOG8KD918	GO:0008586	1/99	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG8KD918	GO:0046872	1/99	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8MD0DR	GO:0005737	3/39	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8MD0DR	GO:0005634	3/39	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8MD0DR	GO:0032793	3/39	positive regulation of CREB transcription factor activity	biological_process	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb]
EOG8MD0DR	GO:0008140	1/39	cAMP response element binding protein binding	molecular_function	"Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein)." [GOC:mah]
EOG8MD0DR	GO:0051289	1/39	protein homotetramerization	biological_process	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]
EOG8MD0DW	GO:0016021	27/102	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8MD0DW	GO:0004252	27/102	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8MD0DW	GO:0005509	24/102	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG80VZ4V	GO:0004514	30/115	nicotinate-nucleotide diphosphorylase (carboxylating) activity	molecular_function	"Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate." [EC:2.4.2.19, RHEA:12736]
EOG80VZ4V	GO:0009435	30/115	NAD biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]
EOG80VZ4V	GO:0004516	22/115	nicotinate phosphoribosyltransferase activity	molecular_function	"Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate." [EC:2.4.2.11, RHEA:13396]
EOG80VZ4V	GO:0019358	22/115	nicotinate nucleotide salvage	biological_process	"The generation of nicotinate nucleotide without de novo synthesis." [GOC:go_curators]
EOG80VZ4V	GO:0016763	1/115	transferase activity, transferring pentosyl groups	molecular_function	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG80VZ4V	GO:0005829	1/115	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG80VZ4V	GO:0006979	1/115	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG80VZ4V	GO:0016874	1/115	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8FFGJP	GO:0006355	3/12	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8FFGJP	GO:0003677	3/12	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8K6JKD	GO:0046872	30/95	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8K6JKD	GO:0006801	19/95	superoxide metabolic process	biological_process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl]
EOG8K6JKD	GO:0055114	19/95	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8K6JKD	GO:0004784	13/95	superoxide dismutase activity	molecular_function	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]
EOG8K6JKD	GO:0030001	10/95	metal ion transport	biological_process	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8K6JKD	GO:0016532	2/95	superoxide dismutase copper chaperone activity	molecular_function	"A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity." [GOC:vw, http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:15064408, PMID:9295278]
EOG8K6JKD	GO:0005777	1/95	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8K6JKD	GO:0006979	1/95	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8K6JKD	GO:0008340	1/95	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8K6JKD	GO:0005737	1/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8K6JKD	GO:0050821	1/95	protein stabilization	biological_process	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]
EOG8K6JKD	GO:0008270	1/95	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8K6JKD	GO:0043085	1/95	positive regulation of catalytic activity	biological_process	"Any process that activates or increases the activity of an enzyme." [GOC:jl, GOC:tb]
EOG8K6JKD	GO:0019430	1/95	removal of superoxide radicals	biological_process	"Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [CHEBI:18421, GOC:jl]
EOG8X3KF3	GO:0006353	7/151	DNA-templated transcription, termination	biological_process	"The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161]
EOG8X3KF3	GO:0003887	1/151	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8X3KF3	GO:0008408	1/151	3'-5' exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]
EOG8X3KF3	GO:0003676	1/151	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X3KF3	GO:0006298	1/151	mismatch repair	biological_process	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
EOG8X3KF3	GO:0000166	1/151	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8X3KF3	GO:0004519	1/151	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8X3KF3	GO:0003677	1/151	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8K6JKH	GO:0051056	2/110	regulation of small GTPase mediated signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
EOG8K6JKH	GO:0005622	2/110	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8K6JKH	GO:0005096	2/110	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8K6JKH	GO:0032851	1/110	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8K6JKH	GO:0000139	1/110	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8K6JKH	GO:0035418	1/110	protein localization to synapse	biological_process	"Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf]
EOG8K6JKH	GO:0060078	1/110	regulation of postsynaptic membrane potential	biological_process	"Any process that modulates the potential difference across a post-synaptic membrane." [GOC:dph, GOC:ef]
EOG8K6JKH	GO:0017112	1/110	Rab guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8K6JKH	GO:0016021	1/110	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8K6JKH	GO:0017137	1/110	Rab GTPase binding	molecular_function	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG8K6JKH	GO:0016023	1/110	cytoplasmic membrane-bounded vesicle	cellular_component	"A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
EOG8K6JKH	GO:0045467	1/110	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8K6JKH	GO:0005794	1/110	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8K6JKH	GO:0007411	1/110	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8K6JKH	GO:0050808	1/110	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG8K6JKH	GO:0032483	1/110	regulation of Rab protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]
EOG8MGVP6	GO:0016787	1/29	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8MD0DM	GO:0015671	1/79	oxygen transport	biological_process	"The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8MD0DM	GO:0019825	1/79	oxygen binding	molecular_function	"Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl]
EOG8MD0DM	GO:0005506	1/79	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8MD0DM	GO:0020037	1/79	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8X3KF9	GO:0005509	27/95	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8X3KF9	GO:0006072	27/95	glycerol-3-phosphate metabolic process	biological_process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]
EOG8X3KF9	GO:0009331	27/95	glycerol-3-phosphate dehydrogenase complex	cellular_component	"An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3]
EOG8X3KF9	GO:0004368	26/95	glycerol-3-phosphate dehydrogenase activity	molecular_function	"Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol." [EC:1.1.5.3]
EOG8X3KF9	GO:0052591	2/95	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	molecular_function	"Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." [MetaCyc:GLYC3PDEHYDROG-RXN]
EOG8X3KF9	GO:0004369	2/95	glycerol-3-phosphate oxidase activity	molecular_function	"Catalysis of the reaction: sn-glycerol 3-phosphate + O(2) = glycerone phosphate + H(2)O(2)." [EC:1.1.3.21, RHEA:18372]
EOG8X3KF9	GO:0005743	1/95	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8X3KF9	GO:0005811	1/95	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8X3KF9	GO:0005739	1/95	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8X3KF9	GO:0032440	1/95	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8X3KF9	GO:0007629	1/95	flight behavior	biological_process	"The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
EOG8X3KF9	GO:0022008	1/95	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8X3KF9	GO:0006127	1/95	glycerophosphate shuttle	biological_process	"The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:071672009, PMID:16368075]
EOG8XD65N	GO:0016021	31/110	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XD65N	GO:0055085	31/110	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8XD65N	GO:0045477	1/110	regulation of nurse cell apoptotic process	biological_process	"Any process that modulates the frequency, rate or extent of nurse cell apoptotic process." [GOC:mtg_apoptosis, PMID:11973306]
EOG8XD65N	GO:0045476	1/110	nurse cell apoptotic process	biological_process	"Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306]
EOG8XD65N	GO:0035193	1/110	larval central nervous system remodeling	biological_process	"Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster." [GOC:sensu, PMID:9647692]
EOG8XD65N	GO:0007619	1/110	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG8XD65N	GO:0051124	1/110	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8XD65N	GO:0006869	1/110	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG8XD65N	GO:0008582	1/110	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8XD65N	GO:0004174	1/110	electron-transferring-flavoprotein dehydrogenase activity	molecular_function	"Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol." [EC:1.5.5.1]
EOG8XD65N	GO:0009267	1/110	cellular response to starvation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]
EOG8XD65N	GO:0043067	1/110	regulation of programmed cell death	biological_process	"Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
EOG8XD65N	GO:0008333	1/110	endosome to lysosome transport	biological_process	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]
EOG8XD65N	GO:0010001	1/110	glial cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]
EOG8XD65N	GO:0031902	1/110	late endosome membrane	cellular_component	"The lipid bilayer surrounding a late endosome." [GOC:pz]
EOG8XD65N	GO:0006897	1/110	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8XD65N	GO:0005765	1/110	lysosomal membrane	cellular_component	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]
EOG8XD65N	GO:0090099	1/110	negative regulation of decapentaplegic signaling pathway	biological_process	"Any process that decreases the frequency, rate, or extent of the decapentaplegic signaling pathway. The decapentaplegic signaling pathway is the series of molecular signals generated as a consequence of the signal decapentaplegic binding to one of its physiological receptors." [GOC:dph, GOC:tb]
EOG8XD65N	GO:0045924	1/110	regulation of female receptivity	biological_process	"Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8XD65N	GO:0007040	1/110	lysosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]
EOG8XD65N	GO:0008347	1/110	glial cell migration	biological_process	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
EOG8XD65N	GO:0007422	1/110	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8XD65N	GO:0040011	1/110	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG8XD65N	GO:0031982	1/110	vesicle	cellular_component	"Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz]
EOG8XD65N	GO:0048488	1/110	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8XD65N	GO:0048477	1/110	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8XD65N	GO:0012501	1/110	programmed cell death	biological_process	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]
EOG8FN6Z0	GO:0004385	2/125	guanylate kinase activity	molecular_function	"Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8]
EOG8FN6Z0	GO:0008105	1/125	asymmetric protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma]
EOG8FN6Z0	GO:0042332	1/125	gravitaxis	biological_process	"The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
EOG8FN6Z0	GO:0004871	1/125	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8FN6Z0	GO:0016336	1/125	establishment or maintenance of polarity of larval imaginal disc epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium." [GOC:jl, GOC:mah]
EOG8FN6Z0	GO:0030710	1/125	regulation of border follicle cell delamination	biological_process	"Any process that regulates the frequency, rate or extent of border cell delamination." [PMID:10822261]
EOG8FN6Z0	GO:0051124	1/125	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8FN6Z0	GO:0007617	1/125	mating behavior	biological_process	"The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph]
EOG8FN6Z0	GO:0016334	1/125	establishment or maintenance of polarity of follicular epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah]
EOG8FN6Z0	GO:0045211	1/125	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8FN6Z0	GO:0008104	1/125	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8FN6Z0	GO:0045167	1/125	asymmetric protein localization involved in cell fate determination	biological_process	"Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai]
EOG8FN6Z0	GO:0005886	1/125	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8FN6Z0	GO:0060581	1/125	cell fate commitment involved in pattern specification	biological_process	"The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph]
EOG8FN6Z0	GO:0005938	1/125	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8FN6Z0	GO:0016332	1/125	establishment or maintenance of polarity of embryonic epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah]
EOG8FN6Z0	GO:0005198	1/125	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8FN6Z0	GO:0051726	1/125	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8FN6Z0	GO:0016020	1/125	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8FN6Z0	GO:0008285	1/125	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8FN6Z0	GO:0002009	1/125	morphogenesis of an epithelium	biological_process	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
EOG8FN6Z0	GO:0061176	1/125	type Ib terminal bouton	cellular_component	"Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons." [GOC:dph, GOC:mc]
EOG8FN6Z0	GO:0016333	1/125	morphogenesis of follicular epithelium	biological_process	"The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl]
EOG8FN6Z0	GO:0005918	1/125	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG8FN6Z0	GO:0042058	1/125	regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8FN6Z0	GO:0046956	1/125	positive phototaxis	biological_process	"The directed movement of a cell or organism towards a source of light." [GOC:ai]
EOG8FN6Z0	GO:0008049	1/125	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8FN6Z0	GO:0016327	1/125	apicolateral plasma membrane	cellular_component	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
EOG8FN6Z0	GO:0000132	1/125	establishment of mitotic spindle orientation	biological_process	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
EOG8FN6Z0	GO:0001708	1/125	cell fate specification	biological_process	"The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators]
EOG8FN6Z0	GO:0030707	1/125	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8FN6Z0	GO:0001738	1/125	morphogenesis of a polarized epithelium	biological_process	"The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]
EOG8FN6Z0	GO:0046939	1/125	nucleotide phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]
EOG8FN6Z0	GO:0051294	1/125	establishment of spindle orientation	biological_process	"Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai]
EOG8FN6Z0	GO:0043195	1/125	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG8FN6Z0	GO:0007155	1/125	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8FN6Z0	GO:0005154	1/125	epidermal growth factor receptor binding	molecular_function	"Interacting selectively and non-covalently with the epidermal growth factor receptor." [GOC:ai]
EOG8FN6Z0	GO:0016328	1/125	lateral plasma membrane	cellular_component	"The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr]
EOG8FN6Z0	GO:0016323	1/125	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG8FN6Z0	GO:0016335	1/125	morphogenesis of larval imaginal disc epithelium	biological_process	"The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl]
EOG8FN6Z0	GO:0007268	1/125	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8FN6Z0	GO:0000122	1/125	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8FN6Z0	GO:0045196	1/125	establishment or maintenance of neuroblast polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083]
EOG8FN6Z0	GO:0005515	1/125	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FN6Z0	GO:0045179	1/125	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8FN6Z0	GO:0007318	1/125	pole plasm protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
EOG8FN6Z0	GO:0008593	1/125	regulation of Notch signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8FN6Z0	GO:0005920	1/125	smooth septate junction	cellular_component	"A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298]
EOG8FN6Z0	GO:0030714	1/125	anterior/posterior axis specification, follicular epithelium	biological_process	"Polarization of the follicle cells of an insect ovary along the anterior/posterior axis." [GOC:bf]
EOG8FN6Z0	GO:0007391	1/125	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8FN6Z0	GO:0045175	1/125	basal protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf]
EOG8FN6Z0	GO:0008283	1/125	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8FN6Z0	GO:0048471	1/125	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8FN6Z0	GO:0046425	1/125	regulation of JAK-STAT cascade	biological_process	"Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf]
EOG8FN6Z0	GO:0045197	1/125	establishment or maintenance of epithelial cell apical/basal polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]
EOG8FN6Z0	GO:0031594	1/125	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8FN6Z0	GO:0007399	1/125	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8FN6Z0	GO:0005856	1/125	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8FN6Z0	GO:0045202	1/125	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8FN6Z0	GO:0045475	1/125	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8FN6Z0	GO:0045887	1/125	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8FN6Z0	GO:0042127	1/125	regulation of cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
EOG8FN6Z0	GO:0019991	1/125	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG8FN6Z0	GO:0007010	1/125	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8FN6Z7	GO:0003676	19/196	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG86T5J0	GO:0046872	10/79	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG86T5J0	GO:0003676	1/79	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82NMGR	GO:0005739	21/66	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG82NMGR	GO:0004129	21/66	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8FN6Z8	GO:0030170	38/119	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8FN6Z8	GO:0003824	31/119	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8FN6Z8	GO:0016829	4/119	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8FN6Z8	GO:0004123	3/119	cystathionine gamma-lyase activity	molecular_function	"Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+." [RHEA:24918]
EOG8FN6Z8	GO:0080146	2/119	L-cysteine desulfhydrase activity	molecular_function	"Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+." [MetaCyc:LCYSDESULF-RXN, PMID:19955263]
EOG8FN6Z8	GO:0044540	2/119	L-cystine L-cysteine-lyase (deaminating)	molecular_function	"Catalysis of the reaction: L-cystine + H2O <=> pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide." [GOC:jl, RHEA:24930]
EOG8FN6Z8	GO:0000096	1/119	sulfur amino acid metabolic process	biological_process	"The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai]
EOG8FN6Z8	GO:0006750	1/119	glutathione biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, GOC:al, GOC:pde, ISBN:0198506732]
EOG8XD65B	GO:0005524	64/182	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8XD65B	GO:0006096	62/182	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8XD65B	GO:0004396	40/182	hexokinase activity	molecular_function	"Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1]
EOG8XD65B	GO:0016773	24/182	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8XD65B	GO:0016301	23/182	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8XD65B	GO:0008865	3/182	fructokinase activity	molecular_function	"Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate." [EC:2.7.1.4]
EOG8XD65B	GO:0051156	3/182	glucose 6-phosphate metabolic process	biological_process	"The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]
EOG8XD65B	GO:0046835	3/182	carbohydrate phosphorylation	biological_process	"The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732]
EOG8XD65B	GO:0001678	3/182	cellular glucose homeostasis	biological_process	"A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8XD65B	GO:0005829	3/182	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8XD65B	GO:0019158	3/182	mannokinase activity	molecular_function	"Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate." [EC:2.7.1.7]
EOG8XD65B	GO:0004340	3/182	glucokinase activity	molecular_function	"Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate." [EC:2.7.1.2]
EOG8XD65B	GO:0005975	3/182	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8XD65B	GO:0019318	1/182	hexose metabolic process	biological_process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
EOG8XD65B	GO:0060361	1/182	flight	biological_process	"Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph]
EOG8XD65B	GO:0046331	1/182	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8WWV2W	GO:0004129	51/102	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8WWV2W	GO:0005746	51/102	mitochondrial respiratory chain	cellular_component	"The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684]
EOG8WWV2H	GO:0005834	22/69	heterotrimeric G-protein complex	cellular_component	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684]
EOG8WWV2H	GO:0007186	22/69	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8WWV2H	GO:0004871	22/69	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8XD65X	GO:0004984	25/128	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8XD65X	GO:0005549	25/128	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8XD65X	GO:0016021	21/128	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XD65X	GO:0004930	21/128	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8XD65X	GO:0005886	12/128	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8XD65X	GO:0016020	4/128	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8PRW4R	GO:0004725	18/81	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8PRW4R	GO:0048477	1/81	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG85TG28	GO:0005634	28/94	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85TG28	GO:0006289	28/94	nucleotide-excision repair	biological_process	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]
EOG85TG28	GO:0003697	28/94	single-stranded DNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174]
EOG85TG28	GO:0004519	28/94	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG85TG28	GO:0070914	1/94	UV-damage excision repair	biological_process	"A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GOC:mah, PMID:9619100]
EOG8SJ7WT	GO:0006509	4/16	membrane protein ectodomain proteolysis	biological_process	"The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/]
EOG8SJ7WT	GO:0007219	4/16	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8SJ7WT	GO:0004222	4/16	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8SJ7WT	GO:0008270	3/16	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SJ7WW	GO:0046580	1/95	negative regulation of Ras protein signal transduction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
EOG876NG7	GO:0005634	2/86	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG876NG7	GO:0005737	2/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG876NG7	GO:0048471	2/86	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG876NG7	GO:0005783	2/86	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG876NG7	GO:0006913	2/86	nucleocytoplasmic transport	biological_process	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]
EOG876NG7	GO:0005875	1/86	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG876NG7	GO:0007017	1/86	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG876NG7	GO:0008017	1/86	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG85TG21	GO:0003676	23/101	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85TG21	GO:0004527	19/101	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG85TG21	GO:0004535	3/101	poly(A)-specific ribonuclease activity	molecular_function	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]
EOG85TG21	GO:0008233	3/101	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG85TG21	GO:0004221	2/101	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG85TG21	GO:0005515	1/101	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG85TG21	GO:0000289	1/101	nuclear-transcribed mRNA poly(A) tail shortening	biological_process	"Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc]
EOG85TG24	GO:0046872	19/92	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85TG24	GO:0008143	1/92	poly(A) binding	molecular_function	"Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl]
EOG85TG24	GO:0006909	1/92	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG85TG24	GO:0005634	1/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85TG25	GO:0015936	27/102	coenzyme A metabolic process	biological_process	"The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
EOG85TG25	GO:0004420	27/102	hydroxymethylglutaryl-CoA reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH." [EC:1.1.1.34, RHEA:15992]
EOG85TG25	GO:0016021	26/102	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85TG25	GO:0008299	23/102	isoprenoid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
EOG85TG25	GO:0050661	23/102	NADP binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]
EOG85TG25	GO:0005789	19/102	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG85TG25	GO:0050662	4/102	coenzyme binding	molecular_function	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
EOG85TG25	GO:0007280	1/102	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG85TG25	GO:0035050	1/102	embryonic heart tube development	biological_process	"The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
EOG85TG25	GO:0008354	1/102	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG85TG25	GO:0007626	1/102	locomotory behavior	biological_process	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
EOG85TG25	GO:0005622	1/102	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG85TG25	GO:0018990	1/102	ecdysis, chitin-based cuticle	biological_process	"The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG85TG25	GO:0008406	1/102	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG85TG25	GO:0035232	1/102	germ cell attraction	biological_process	"The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target." [PMID:12885551]
EOG8J13P1	GO:0008021	22/123	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8J13P1	GO:0005215	22/123	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8J13P1	GO:0016020	22/123	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8J13P1	GO:0006886	8/123	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8J13P1	GO:0046872	1/123	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8J13P1	GO:0035005	1/123	1-phosphatidylinositol-4-phosphate 3-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.154, RHEA:18376]
EOG8J13P3	GO:0004984	17/30	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8J13P3	GO:0016021	17/30	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J13P3	GO:0004930	17/30	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8J13P3	GO:0005549	17/30	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8J13P3	GO:0005886	13/30	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8J13P3	GO:0050911	1/30	detection of chemical stimulus involved in sensory perception of smell	biological_process	"The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8J13P3	GO:0007186	1/30	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8J13P3	GO:0007608	1/30	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8SJ7WG	GO:0008270	5/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SJ7WG	GO:0048786	1/91	presynaptic active zone	cellular_component	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
EOG8SJ7WG	GO:0001956	1/91	positive regulation of neurotransmitter secretion	biological_process	"Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd]
EOG8SJ7WG	GO:2000809	1/91	positive regulation of synaptic vesicle clustering	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic vesicle clustering." [PMID:21513708]
EOG8SJ7WF	GO:0016491	61/186	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8SJ7WF	GO:0004303	2/186	estradiol 17-beta-dehydrogenase activity	molecular_function	"Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62]
EOG8SJ7WF	GO:0006909	1/186	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8SJ7WF	GO:0005783	1/186	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8SJ7WF	GO:0008285	1/186	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8SJ7WF	GO:0007030	1/186	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8SJ7W6	GO:0003676	14/99	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SJ7W6	GO:0008270	14/99	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SJ7W6	GO:0004504	1/99	peptidylglycine monooxygenase activity	molecular_function	"Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3]
EOG8SJ7W6	GO:0005507	1/99	copper ion binding	molecular_function	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]
EOG8SJ7W6	GO:0006518	1/99	peptide metabolic process	biological_process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [CHEBI:16670, GOC:go_curators]
EOG8SJ7W6	GO:0016020	1/99	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG85TG2V	GO:0016021	1/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85TG2V	GO:0015299	1/6	solute:proton antiporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]
EOG8P8HZ3	GO:0046355	41/115	mannan catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732]
EOG8P8HZ3	GO:0004567	41/115	beta-mannosidase activity	molecular_function	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides." [EC:3.2.1.25]
EOG8P8HZ3	GO:0004553	1/115	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8P8HZ3	GO:0005975	1/115	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8J13PT	GO:0016772	28/94	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG85TG2C	GO:0016887	3/13	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG85TG2C	GO:0005524	3/13	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG85TG2C	GO:0016020	2/13	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG85TG2C	GO:0015197	2/13	peptide transporter activity	molecular_function	"Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells." [GOC:ai]
EOG876NGJ	GO:0008270	50/131	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG876NGJ	GO:0005634	2/131	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG876NGJ	GO:0060537	2/131	muscle tissue development	biological_process	"The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]
EOG876NGJ	GO:0007517	2/131	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG876NGJ	GO:0005737	1/131	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG876NGJ	GO:0045214	1/131	sarcomere organization	biological_process	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
EOG876NGJ	GO:0030018	1/131	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG876NGJ	GO:0030154	1/131	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG876NGJ	GO:0090175	1/131	regulation of establishment of planar polarity	biological_process	"Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG876NGJ	GO:0008307	1/131	structural constituent of muscle	molecular_function	"The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah]
EOG8BS030	GO:0046872	20/60	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8BS030	GO:0003676	13/60	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QNQ8Z	GO:0016301	6/121	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8QNQ8Z	GO:0005524	6/121	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8G7FC2	GO:0016773	26/127	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8G7FC2	GO:0016301	12/127	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8G7FC2	GO:0005524	12/127	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8G7FC2	GO:0005634	1/127	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8G7FC2	GO:0000184	1/127	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	biological_process	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]
EOG8G7FC2	GO:0006396	1/127	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8G7FC2	GO:0046777	1/127	protein autophosphorylation	biological_process	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
EOG8G7FC2	GO:0007274	1/127	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8G7FC2	GO:0004674	1/127	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8G7FC2	GO:0016310	1/127	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG8G7FC2	GO:0006950	1/127	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8G7FC2	GO:0050808	1/127	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG8G7FC2	GO:0018105	1/127	peptidyl-serine phosphorylation	biological_process	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]
EOG8G7FC2	GO:0005737	1/127	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8G7FC2	GO:0004672	1/127	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8G7FC2	GO:0046872	1/127	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8G7FC2	GO:0008144	1/127	drug binding	molecular_function	"Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732]
EOG8G7FC2	GO:0048489	1/127	synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr]
EOG86T5JP	GO:0008033	1/12	tRNA processing	biological_process	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]
EOG86T5JP	GO:0005524	1/12	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WWV25	GO:0003676	3/11	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WWV25	GO:0046872	3/11	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WWV27	GO:0006811	2/34	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8WWV27	GO:0016021	2/34	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FN6ZB	GO:0008270	33/186	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FN6ZB	GO:0003700	32/186	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8FN6ZB	GO:0005634	32/186	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FN6ZB	GO:0043565	31/186	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8FN6ZB	GO:0016740	2/186	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8FN6ZB	GO:0003677	2/186	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FN6ZB	GO:0000977	1/186	RNA polymerase II regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
EOG8FN6ZB	GO:0035218	1/186	leg disc development	biological_process	"Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
EOG8FN6ZB	GO:0007517	1/186	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8FN6ZB	GO:0007450	1/186	dorsal/ventral pattern formation, imaginal disc	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238]
EOG8FN6ZB	GO:0007399	1/186	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8FN6ZB	GO:0045165	1/186	cell fate commitment	biological_process	"The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
EOG8FN6ZB	GO:0007526	1/186	larval somatic muscle development	biological_process	"The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG8FN6ZB	GO:0007559	1/186	histolysis	biological_process	"The breakdown of tissues; usually, if not always, accompanied by cell death, followed by the complete dissolution of dead tissue." [GOC:dph, GOC:ma]
EOG8FN6ZB	GO:0045944	1/186	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8FN6ZB	GO:0007476	1/186	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8FN6ZB	GO:0007479	1/186	leg disc proximal/distal pattern formation	biological_process	"The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf]
EOG8FN6ZB	GO:0048190	1/186	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8FN6ZB	GO:0006351	1/186	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8FN6ZB	GO:0007411	1/186	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8FN6ZB	GO:0036011	1/186	imaginal disc-derived leg segmentation	biological_process	"Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf]
EOG8FN6ZB	GO:0007451	1/186	dorsal/ventral lineage restriction, imaginal disc	biological_process	"Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402]
EOG8XD656	GO:0005875	1/46	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8XD656	GO:0007052	1/46	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8XD656	GO:0007088	1/46	regulation of mitotic nuclear division	biological_process	"Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
EOG8SXQWC	GO:0004930	65/251	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8SXQWC	GO:0016021	65/251	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SXQWC	GO:0007186	4/251	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8SXQWC	GO:0005886	3/251	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8SXQWC	GO:0008366	2/251	axon ensheathment	biological_process	"Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437]
EOG8SXQWC	GO:0048148	2/251	behavioral response to cocaine	biological_process	"Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid]
EOG8SXQWC	GO:0004252	2/251	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8SXQWC	GO:0060857	1/251	establishment of glial blood-brain barrier	biological_process	"Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
EOG8SXQWC	GO:0007281	1/251	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8SXQWC	GO:0035095	1/251	behavioral response to nicotine	biological_process	"Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus." [GOC:bf, ISBN:0198506732]
EOG8SXQWC	GO:0048149	1/251	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8SXQWC	GO:0008354	1/251	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8SXQWC	GO:0007419	1/251	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8SXQWC	GO:0030866	1/251	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8SXQWC	GO:0019991	1/251	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG8SXQWC	GO:0035234	1/251	ectopic germ cell programmed cell death	biological_process	"Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944]
EOG8SXQWC	GO:0005938	1/251	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8SXQWC	GO:0005919	1/251	pleated septate junction	cellular_component	"A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298]
EOG8SXQWC	GO:0007280	1/251	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG8SXQWC	GO:0050254	1/251	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8SXQWC	GO:0007218	1/251	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8FBM7Z	GO:0005634	25/120	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FBM7Z	GO:0003700	25/120	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8FBM7Z	GO:0006260	25/120	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8FBM7Z	GO:0006351	22/120	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8FBM7Z	GO:0003677	2/120	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FBM7Z	GO:0007179	1/120	transforming growth factor beta receptor signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
EOG8FBM7Z	GO:0005667	1/120	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8MKQWT	GO:0008270	26/95	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MKQWT	GO:0004842	1/95	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8MKQWT	GO:0031648	1/95	protein destabilization	biological_process	"Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah]
EOG8MKQWQ	GO:0003896	30/107	DNA primase activity	molecular_function	"Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases." [GOC:mah, GOC:mcc, ISBN:0716720094, PMID:26184436]
EOG8MKQWQ	GO:0051539	1/107	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8MKQWQ	GO:0000278	1/107	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8MKQWQ	GO:1990077	1/107	primosome complex	cellular_component	"Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms.  Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart." [GOC:bhm, GOC:mah, PMID:21856207]
EOG8MKQWQ	GO:0046872	1/107	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8MKQWQ	GO:0006261	1/107	DNA-dependent DNA replication	biological_process	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]
EOG8MKQWQ	GO:0001745	1/107	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8MKQWQ	GO:0003887	1/107	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8MKQWQ	GO:0003677	1/107	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8MKQWQ	GO:0005658	1/107	alpha DNA polymerase:primase complex	cellular_component	"A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402]
EOG8MKQWQ	GO:0006260	1/107	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG85MQK9	GO:0030983	29/98	mismatched DNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]
EOG85MQK9	GO:0005524	29/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG85MQK9	GO:0006298	29/98	mismatch repair	biological_process	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
EOG85MQK9	GO:0032389	29/98	MutLalpha complex	cellular_component	"A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2." [GOC:vk]
EOG85MQK9	GO:0005875	1/98	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG85MQK9	GO:0006200	1/98	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG85MQK9	GO:0016887	1/98	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG85MQK9	GO:0003697	1/98	single-stranded DNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174]
EOG8MKQWM	GO:0008270	27/111	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MKQWM	GO:0004222	27/111	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8MKQWM	GO:0031012	27/111	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8MKQWM	GO:0005509	11/111	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8MKQWM	GO:0005886	1/111	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8MKQWM	GO:0035202	1/111	tracheal pit formation in open tracheal system	biological_process	"Formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940, PMID:11992723, PMID:14570584]
EOG8MKQWM	GO:0007426	1/111	tracheal outgrowth, open tracheal system	biological_process	"The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8MKQWM	GO:0007561	1/111	imaginal disc eversion	biological_process	"The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317]
EOG8MKQWM	GO:0071711	1/111	basement membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah]
EOG8MKQWM	GO:0030425	1/111	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8MKQWM	GO:0046331	1/111	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8MKQWM	GO:0007424	1/111	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8MKQWM	GO:0034769	1/111	basement membrane disassembly	biological_process	"The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221]
EOG8MKQWM	GO:0046529	1/111	imaginal disc fusion, thorax closure	biological_process	"The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm]
EOG8MKQWM	GO:0040037	1/111	negative regulation of fibroblast growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8MKQWM	GO:0002218	1/111	activation of innate immune response	biological_process	"Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805]
EOG8MKQWM	GO:0042060	1/111	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8MKQWM	GO:0003677	1/111	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TF30R	GO:0004386	8/57	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8TF30R	GO:0005524	8/57	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8TF30R	GO:0003677	8/57	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TF30R	GO:0016740	2/57	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG83FKB4	GO:0016779	24/97	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG83FKB4	GO:0003983	3/97	UTP:glucose-1-phosphate uridylyltransferase activity	molecular_function	"Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose." [EC:2.7.7.9, RHEA:19892]
EOG834ZP6	GO:0003676	10/381	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG834ZP6	GO:0008270	8/381	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG834ZP6	GO:0004190	6/381	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG834ZP6	GO:0003723	1/381	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG834ZP6	GO:0004984	1/381	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG834ZP6	GO:0016020	1/381	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG834ZP6	GO:0003964	1/381	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG834ZP6	GO:0005549	1/381	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG85MQK7	GO:0040011	1/91	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG85MQK7	GO:0007099	1/91	centriole replication	biological_process	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194]
EOG85MQK7	GO:0007140	1/91	male meiosis	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
EOG85MQK7	GO:0051298	1/91	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG85MQK7	GO:0051297	1/91	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG85MQK7	GO:0008356	1/91	asymmetric cell division	biological_process	"The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
EOG85MQK7	GO:0005814	1/91	centriole	cellular_component	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
EOG85MQK7	GO:0042384	1/91	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG85MQK7	GO:0007052	1/91	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG85MQK7	GO:0035186	1/91	syncytial blastoderm mitotic cell cycle	biological_process	"Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238]
EOG85MQK7	GO:0000242	1/91	pericentriolar material	cellular_component	"A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]
EOG84F8QS	GO:0008234	10/52	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG86X1RN	GO:0016021	11/82	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86X1RN	GO:0016020	7/82	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG86X1RN	GO:0007520	1/82	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG85B3XK	GO:0016787	2/13	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG85B3XK	GO:0016813	1/13	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]
EOG85B3XK	GO:0016705	1/13	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG85B3XK	GO:0046872	1/13	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85B3XK	GO:0008080	1/13	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG84F8QF	GO:0007299	1/102	ovarian follicle cell-cell adhesion	biological_process	"The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12642496]
EOG84F8QF	GO:0007259	1/102	JAK-STAT cascade	biological_process	"Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028]
EOG84F8QF	GO:0046843	1/102	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG84F8QF	GO:0007010	1/102	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG84F8QF	GO:0007162	1/102	negative regulation of cell adhesion	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators]
EOG84F8QF	GO:0016020	1/102	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG84F8QF	GO:0005737	1/102	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84F8QF	GO:0060250	1/102	germ-line stem-cell niche homeostasis	biological_process	"A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion." [GOC:dph]
EOG84F8QF	GO:0005634	1/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84F8QF	GO:0030536	1/102	larval feeding behavior	biological_process	"Feeding behavior in a larval (immature) organism." [GOC:mah]
EOG84F8QM	GO:0005975	94/390	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG84F8QM	GO:0004553	93/390	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG84F8QM	GO:0008422	1/390	beta-glucosidase activity	molecular_function	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21]
EOG84F8QM	GO:0008970	1/390	phosphatidylcholine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32]
EOG84F8QM	GO:0052740	1/390	1-acyl-2-lysophosphatidylserine acylhydrolase activity	molecular_function	"Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32]
EOG84F8QM	GO:0052739	1/390	phosphatidylserine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG:R04034]
EOG85XBCG	GO:0004623	1/77	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG834ZN4	GO:0005615	3/311	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG84F8Q5	GO:0005089	19/85	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG84F8Q5	GO:0035556	1/85	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG84F8Q5	GO:0007480	1/85	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG834ZN6	GO:0005634	4/58	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG834ZN6	GO:0006302	3/58	double-strand break repair	biological_process	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]
EOG834ZN6	GO:0003677	3/58	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG834ZN6	GO:0006310	3/58	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG834ZN6	GO:0006281	1/58	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG80P6PD	GO:0008289	3/54	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG8JMB3S	GO:0003987	25/104	acetate-CoA ligase activity	molecular_function	"Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [EC:6.2.1.1]
EOG8JMB3S	GO:0016208	23/104	AMP binding	molecular_function	"Interacting selectively and non-covalently with AMP, adenosine monophosphate." [GOC:go_curators]
EOG8JMB3S	GO:0019427	23/104	acetyl-CoA biosynthetic process from acetate	biological_process	"The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate." [MetaCyc:ACETATEUTIL-PWY]
EOG8JMB3S	GO:0003824	3/104	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8JMB3S	GO:0005737	1/104	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8JMB3S	GO:0005524	1/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8JMB3S	GO:0048149	1/104	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8SXQWQ	GO:0051726	1/55	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG84TRP6	GO:0005524	25/88	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG84TRP6	GO:0043141	25/88	ATP-dependent 5'-3' DNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl]
EOG84TRP6	GO:0035267	3/88	NuA4 histone acetyltransferase complex	cellular_component	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]
EOG84TRP6	GO:0031011	3/88	Ino80 complex	cellular_component	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820]
EOG84TRP6	GO:0043486	3/88	histone exchange	biological_process	"The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]
EOG84TRP6	GO:0042127	3/88	regulation of cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
EOG84TRP6	GO:0016573	3/88	histone acetylation	biological_process	"The modification of a histone by the addition of an acetyl group." [GOC:ai]
EOG84TRP6	GO:0003714	3/88	transcription corepressor activity	molecular_function	"Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG84TRP6	GO:0030111	3/88	regulation of Wnt signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]
EOG84TRP6	GO:0006281	3/88	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG84TRP6	GO:0006351	3/88	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG84TRP6	GO:0006355	2/88	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG84TRP6	GO:0034773	1/88	histone H4-K20 trimethylation	biological_process	"The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone." [GOC:mah]
EOG84TRP6	GO:0035102	1/88	PRC1 complex	cellular_component	"A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979]
EOG84TRP6	GO:0042799	1/88	histone methyltransferase activity (H4-K20 specific)	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein." [PMID:12086618]
EOG84TRP6	GO:0010629	1/88	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG84TRP6	GO:0000123	1/88	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG84TRP6	GO:0005875	1/88	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG84TRP6	GO:0006342	1/88	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG84TRP6	GO:0005634	1/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84TRP6	GO:0005515	1/88	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG84TRP6	GO:0022008	1/88	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84TRP6	GO:0007095	1/88	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8DZ48Z	GO:0046872	103/368	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DZ48Z	GO:0003676	100/368	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DZ48Z	GO:0043565	4/368	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8DZ48Z	GO:0050774	1/368	negative regulation of dendrite morphogenesis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG8DZ48Z	GO:0048814	1/368	regulation of dendrite morphogenesis	biological_process	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG8DZ48Z	GO:0022008	1/368	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8JMB3F	GO:0016021	5/144	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JMB3F	GO:0005886	5/144	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8JMB3F	GO:0004930	4/144	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8JMB3F	GO:0004984	4/144	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8JMB3F	GO:0005549	4/144	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8JMB3F	GO:0003676	2/144	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JMB3F	GO:0015074	1/144	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8JMB3F	GO:0050909	1/144	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG81ZHRD	GO:0022008	1/89	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG81ZHRD	GO:0007292	1/89	female gamete generation	biological_process	"Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732]
EOG81ZHRD	GO:0007444	1/89	imaginal disc development	biological_process	"The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238]
EOG81ZHRD	GO:0003677	1/89	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81ZHRD	GO:0048477	1/89	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG81ZHRD	GO:0002164	1/89	larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088]
EOG84TRP9	GO:0003676	27/100	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84TRP9	GO:0000166	26/100	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG84TRP9	GO:0016363	1/100	nuclear matrix	cellular_component	"The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]
EOG84TRP9	GO:0003729	1/100	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG84TRP9	GO:0000381	1/100	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG84TRP9	GO:0005654	1/100	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG84TRP9	GO:0005634	1/100	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83FKBM	GO:0003676	2/20	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83FKBK	GO:0004634	1/3	phosphopyruvate hydratase activity	molecular_function	"Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732]
EOG83FKBK	GO:0000015	1/3	phosphopyruvate hydratase complex	cellular_component	"A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732]
EOG83FKBK	GO:0006096	1/3	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG83FKBK	GO:0000287	1/3	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8MKQW4	GO:0008157	1/118	protein phosphatase 1 binding	molecular_function	"Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl]
EOG8FBM72	GO:0004930	20/109	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8FBM72	GO:0016020	20/109	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8FBM72	GO:0007218	2/109	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8FBM73	GO:0005525	26/95	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8FBM73	GO:0007049	25/95	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG8FBM73	GO:0031105	10/95	septin complex	cellular_component	"A protein complex containing septins.  Typically, these complexes contain multiple septins and are oligomeric." [GOC:mah, PMID:15385632]
EOG8FBM73	GO:0051301	2/95	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8FBM73	GO:0016324	1/95	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8FBM73	GO:0000915	1/95	actomyosin contractile ring assembly	biological_process	"The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
EOG8FBM73	GO:0003779	1/95	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8FBM73	GO:0005940	1/95	septin ring	cellular_component	"A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form." [GOC:krc, GOC:mah, PMID:16009555, PMID:16151244]
EOG8FBM73	GO:0008017	1/95	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8FBM73	GO:0006915	1/95	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8FBM73	GO:0006184	1/95	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8FBM73	GO:0005886	1/95	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8FBM73	GO:0032154	1/95	cleavage furrow	cellular_component	"In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409]
EOG8FBM73	GO:0031625	1/95	ubiquitin protein ligase binding	molecular_function	"Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]
EOG8FBM73	GO:0043065	1/95	positive regulation of apoptotic process	biological_process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8FBM73	GO:0045172	1/95	germline ring canal	cellular_component	"Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801]
EOG8FBM73	GO:0007349	1/95	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG8FBM73	GO:0005515	1/95	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FBM73	GO:0000281	1/95	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8FBM73	GO:0003924	1/95	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8FBM73	GO:0005875	1/95	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG85MQKZ	GO:0030170	30/110	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG85MQKZ	GO:0009058	30/110	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG85MQKZ	GO:0003824	26/110	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG85MQKZ	GO:0047316	3/110	glutamine-phenylpyruvate transaminase activity	molecular_function	"Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine." [EC:2.6.1.64, RHEA:17596]
EOG85MQKZ	GO:0047804	1/110	cysteine-S-conjugate beta-lyase activity	molecular_function	"Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate." [EC:4.4.1.13, MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN]
EOG85MQKZ	GO:0008483	1/110	transaminase activity	molecular_function	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]
EOG83R62D	GO:0016773	37/111	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG83R62D	GO:0005975	37/111	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG83R62D	GO:0004856	3/111	xylulokinase activity	molecular_function	"Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H(+)." [EC:2.7.1.17, RHEA:10967]
EOG83R62D	GO:0016301	1/111	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG834ZPV	GO:0003676	4/44	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NGK1H	GO:0007165	4/58	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8NGK1H	GO:0004674	2/58	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8NGK1H	GO:0005524	2/58	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8NGK1H	GO:0032440	1/58	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8NGK1H	GO:0016301	1/58	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG883GNT	GO:0003964	338/1363	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG883GNT	GO:0003723	333/1363	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG883GNT	GO:0008270	44/1363	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG883GNT	GO:0003676	19/1363	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG883GNT	GO:0004519	4/1363	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG883GNT	GO:0004523	3/1363	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG883GNT	GO:0006511	2/1363	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG883GNT	GO:0046872	2/1363	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG883GNT	GO:0005634	1/1363	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG883GNT	GO:0016020	1/1363	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG883GNT	GO:0034450	1/1363	ubiquitin-ubiquitin ligase activity	molecular_function	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]
EOG883GNT	GO:0005524	1/1363	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG883GNT	GO:0004674	1/1363	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG883GNT	GO:0015074	1/1363	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG883GNT	GO:0006281	1/1363	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG883GNT	GO:0000723	1/1363	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG883GNT	GO:0003677	1/1363	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG883GNT	GO:0000786	1/1363	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG883GNT	GO:0003678	1/1363	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG883GNT	GO:0016758	1/1363	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG883GNT	GO:0006334	1/1363	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG883GNT	GO:0000151	1/1363	ubiquitin ligase complex	cellular_component	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
EOG84XMZQ	GO:0005549	69/258	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8TXF5N	GO:0005248	20/130	voltage-gated sodium channel activity	molecular_function	"Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8TXF5N	GO:0001518	20/130	voltage-gated sodium channel complex	cellular_component	"A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732]
EOG8TXF5N	GO:0005216	8/130	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8TXF5N	GO:0016021	8/130	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TXF5N	GO:0005886	1/130	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8TXF5N	GO:0035725	1/130	sodium ion transmembrane transport	biological_process	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
EOG8TXF5N	GO:0006814	1/130	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8TXF5N	GO:0007608	1/130	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8TXF5N	GO:0008270	1/130	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TXF5N	GO:0003723	1/130	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8TXF5N	GO:0042048	1/130	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG8TXF5N	GO:0022843	1/130	voltage-gated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8TXF5N	GO:0086010	1/130	membrane depolarization during action potential	biological_process	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
EOG8TXF5N	GO:0003964	1/130	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8TXF5N	GO:0019228	1/130	neuronal action potential	biological_process	"An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb]
EOG8NGK1G	GO:0004725	25/171	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8NGK1G	GO:0050254	2/171	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8NGK1G	GO:0001700	1/171	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8NGK1G	GO:0005001	1/171	transmembrane receptor protein tyrosine phosphatase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8NGK1G	GO:0008201	1/171	heparin binding	molecular_function	"Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]
EOG8NGK1G	GO:0048675	1/171	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG8NGK1G	GO:0005925	1/171	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8NGK1G	GO:0005515	1/171	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8NGK1G	GO:0005875	1/171	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8NGK1G	GO:0016021	1/171	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NGK1G	GO:0007412	1/171	axon target recognition	biological_process	"The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437]
EOG8NGK1G	GO:0048841	1/171	regulation of axon extension involved in axon guidance	biological_process	"Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]
EOG8NGK1G	GO:0007399	1/171	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8NGK1G	GO:0035335	1/171	peptidyl-tyrosine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
EOG8NGK1G	GO:0030424	1/171	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8NGK1G	GO:0032093	1/171	SAM domain binding	molecular_function	"Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230]
EOG8NGK1G	GO:0005886	1/171	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8NGK1G	GO:0048477	1/171	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8NGK1G	GO:0007155	1/171	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8NGK1G	GO:0008045	1/171	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8NGK1G	GO:0045467	1/171	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8NGK1G	GO:0007411	1/171	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8NGK1G	GO:0051124	1/171	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8NGK1G	GO:0008594	1/171	photoreceptor cell morphogenesis	biological_process	"The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
EOG8NGK1G	GO:0008360	1/171	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8NGK1G	GO:0016162	1/171	cellulose 1,4-beta-cellobiosidase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91]
EOG8NGK1G	GO:0031290	1/171	retinal ganglion cell axon guidance	biological_process	"The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs]
EOG8NGK1G	GO:0006470	1/171	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG84XMZJ	GO:0005875	1/91	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG84XMZJ	GO:0007097	1/91	nuclear migration	biological_process	"The directed movement of the nucleus." [GOC:ai]
EOG84XMZJ	GO:0005737	1/91	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8FR385	GO:0000166	18/79	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8FR385	GO:0003676	14/79	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FR385	GO:0003743	3/79	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8FR385	GO:0008283	1/79	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8FR385	GO:0005829	1/79	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8FR385	GO:0003729	1/79	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8FR385	GO:0046427	1/79	positive regulation of JAK-STAT cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG8FR385	GO:0006413	1/79	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG8C8B88	GO:0005515	2/75	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8C8B88	GO:0007155	2/75	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8C8B88	GO:0016020	2/75	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NGK1T	GO:0016021	35/159	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NGK1T	GO:0055085	35/159	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG83N9T9	GO:0003743	27/97	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG83N9T9	GO:0016282	26/97	eukaryotic 43S preinitiation complex	cellular_component	"A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049]
EOG83N9T9	GO:0006446	26/97	regulation of translational initiation	biological_process	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG83N9T9	GO:0001731	26/97	formation of translation preinitiation complex	biological_process	"The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd]
EOG83N9T9	GO:0005852	26/97	eukaryotic translation initiation factor 3 complex	cellular_component	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]
EOG83N9T9	GO:0033290	26/97	eukaryotic 48S preinitiation complex	cellular_component	"A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049]
EOG83N9T9	GO:0006413	1/97	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG83N9T9	GO:0004402	1/97	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG83N9T9	GO:0005875	1/97	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8C8B82	GO:0004222	1/8	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8C8B82	GO:0008270	1/8	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8C8B82	GO:0031012	1/8	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8XPSW6	GO:0008270	224/674	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XPSW6	GO:0004222	224/674	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8XPSW6	GO:0006909	1/674	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8XPSW6	GO:0016020	1/674	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XPSW6	GO:0004175	1/674	endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8XPSW6	GO:0032504	1/674	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8XPSW6	GO:0006508	1/674	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8XPSW6	GO:0046331	1/674	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8XPSW6	GO:0005615	1/674	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8XPSW6	GO:0022008	1/674	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8F4VRH	GO:0008270	24/102	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8F4VRH	GO:0003676	1/102	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8F4VRK	GO:0032777	31/95	Piccolo NuA4 histone acetyltransferase complex	cellular_component	"A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p." [GOC:rb, PMID:12782659, PMID:15964809]
EOG8F4VRK	GO:0006351	25/95	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8F4VRK	GO:0006355	25/95	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8F4VRK	GO:0005700	1/95	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8F4VRK	GO:0005725	1/95	intercalary heterochromatin	cellular_component	"Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245]
EOG8F4VRK	GO:0005634	1/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8F4VRK	GO:0043486	1/95	histone exchange	biological_process	"The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]
EOG8F4VRK	GO:0000123	1/95	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG8F4VRK	GO:0035267	1/95	NuA4 histone acetyltransferase complex	cellular_component	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]
EOG8F4VRK	GO:0070983	1/95	dendrite guidance	biological_process	"The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
EOG8F4VRK	GO:0016573	1/95	histone acetylation	biological_process	"The modification of a histone by the addition of an acetyl group." [GOC:ai]
EOG8F4VRK	GO:0006325	1/95	chromatin organization	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
EOG8KWN79	GO:0005794	33/98	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8KWN79	GO:0016021	33/98	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KWN79	GO:0006486	33/98	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8KWN79	GO:0008378	30/98	galactosyltransferase activity	molecular_function	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]
EOG8KWN79	GO:0047915	3/98	ganglioside galactosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine." [EC:2.4.1.62, MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN]
EOG8KWN79	GO:0016757	1/98	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8KWN79	GO:0008152	1/98	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8KWN78	GO:0046872	26/90	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8KWN78	GO:0003676	25/90	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KWN78	GO:0001654	1/90	eye development	biological_process	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
EOG8KWN78	GO:0007423	1/90	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8KWN78	GO:0001078	1/90	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
EOG8KWN78	GO:0045944	1/90	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8KWN78	GO:0042683	1/90	negative regulation of compound eye cone cell fate specification	biological_process	"Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell." [GOC:mtg_sensu]
EOG8KWN78	GO:0001700	1/90	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8KWN78	GO:0007458	1/90	progression of morphogenetic furrow involved in compound eye morphogenesis	biological_process	"The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883]
EOG8KWN78	GO:0048813	1/90	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8KWN78	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KWN78	GO:0005634	1/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8KWN78	GO:0000122	1/90	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8KWN78	GO:0007422	1/90	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8KWN78	GO:0043565	1/90	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8KWN78	GO:0009612	1/90	response to mechanical stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]
EOG8KWN78	GO:0006366	1/90	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8KWN78	GO:0003705	1/90	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG8KWN76	GO:0003677	22/96	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8KWN76	GO:0005634	21/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8KWN76	GO:0005622	1/96	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8GJ23G	GO:0034464	26/101	BBSome	cellular_component	"A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [GOC:BHF, PMID:17574030]
EOG8QNQD6	GO:0004190	4/578	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8QNQD6	GO:0003676	3/578	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QNQD6	GO:0003964	1/578	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8QNQD6	GO:0008270	1/578	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8QNQD6	GO:0003723	1/578	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8QNQD6	GO:0015074	1/578	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG82FVXV	GO:0006950	1/16	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG82FVXV	GO:0016021	1/16	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82FVXV	GO:0055085	1/16	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG82FVXS	GO:0016758	251/467	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG82FVXS	GO:0015020	15/467	glucuronosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17]
EOG82FVXS	GO:0030259	7/467	lipid glycosylation	biological_process	"Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah]
EOG82FVXS	GO:0016999	4/467	antibiotic metabolic process	biological_process	"The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2]
EOG82FVXS	GO:0030246	4/467	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG82FVXS	GO:0003851	1/467	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45]
EOG83R621	GO:0046872	23/85	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83R621	GO:0004722	23/85	protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
EOG83R621	GO:0006470	23/85	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG83R621	GO:0008360	1/85	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG83R621	GO:0003824	1/85	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG83R621	GO:0007155	1/85	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8577P8	GO:0016881	37/106	acid-amino acid ligase activity	molecular_function	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
EOG8577P8	GO:0004842	7/106	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8577P8	GO:0005524	1/106	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8577P8	GO:0005515	1/106	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8577P8	GO:0022008	1/106	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG808QNT	GO:0020037	24/97	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG808QNT	GO:0006979	23/97	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG808QNT	GO:0004601	22/97	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG808QNT	GO:0004447	2/97	iodide peroxidase activity	molecular_function	"Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O." [EC:1.11.1.8]
EOG808QNT	GO:0042744	1/97	hydrogen peroxide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]
EOG808QNT	GO:0030198	1/97	extracellular matrix organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]
EOG808QNT	GO:0046872	1/97	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG808QNT	GO:0005578	1/97	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG808QNT	GO:0006909	1/97	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8KWN7R	GO:0003676	21/135	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KWN7R	GO:0003677	4/135	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8KWN7R	GO:0008270	4/135	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KWN7R	GO:0033014	1/135	tetrapyrrole biosynthetic process	biological_process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah]
EOG8KWN7R	GO:0004852	1/135	uroporphyrinogen-III synthase activity	molecular_function	"Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III." [EC:4.2.1.75, RHEA:18968]
EOG8KWN7R	GO:0035556	1/135	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG808QNS	GO:0016620	1/117	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG808QNR	GO:0005856	8/68	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8KWN7H	GO:0016021	28/81	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KWN7H	GO:0004983	25/81	neuropeptide Y receptor activity	molecular_function	"Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
EOG8KWN7H	GO:0004930	2/81	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8KWN7H	GO:0050254	2/81	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8KWN7H	GO:0004715	2/81	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8KWN7H	GO:2000252	1/81	negative regulation of feeding behavior	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." [GOC:obol]
EOG8KWN7H	GO:0042071	1/81	leucokinin receptor activity	molecular_function	"Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:2716741]
EOG8KWN7H	GO:0007186	1/81	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8KWN7H	GO:0008188	1/81	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8KWN7H	GO:0007204	1/81	positive regulation of cytosolic calcium ion concentration	biological_process	"Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai]
EOG8KWN7H	GO:0016323	1/81	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG8KWN7H	GO:0007218	1/81	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8KWN7H	GO:0009755	1/81	hormone-mediated signaling pathway	biological_process	"A series of molecular signals mediated by the detection of a hormone." [GOC:sm]
EOG8QNQDB	GO:0008270	1/22	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8QNQDB	GO:0003676	1/22	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8F20K4	GO:0005057	2/51	receptor signaling protein activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf]
EOG8F20K1	GO:0051028	1/51	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8F20K1	GO:0005634	1/51	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83N9TB	GO:0005634	2/24	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83N9TB	GO:0008270	2/24	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XWJBR	GO:0005509	25/91	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8XWJBR	GO:0007156	20/91	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8XWJBR	GO:0016021	19/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XWJBR	GO:0005576	1/91	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8XWJBR	GO:0045211	1/91	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8XWJBR	GO:0005887	1/91	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XWJBR	GO:0016339	1/91	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
EOG883GN0	GO:0016740	1/23	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG83N9TJ	GO:0005506	404/1184	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG83N9TJ	GO:0020037	404/1184	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG83N9TJ	GO:0016705	391/1184	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG83N9TJ	GO:0004497	374/1184	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG83N9TJ	GO:0005789	17/1184	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG83N9TJ	GO:0070330	6/1184	aromatase activity	molecular_function	"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
EOG83N9TJ	GO:0052869	6/1184	arachidonic acid omega-hydroxylase activity	molecular_function	"Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid." [KEGG:R07041]
EOG83N9TJ	GO:0018685	6/1184	alkane 1-monooxygenase activity	molecular_function	"Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3]
EOG83N9TJ	GO:0016539	3/1184	intein-mediated protein splicing	biological_process	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]
EOG83N9TJ	GO:0007165	2/1184	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG83N9TJ	GO:0005622	2/1184	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG83N9TJ	GO:0007618	1/1184	mating	biological_process	"The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546]
EOG83N9TJ	GO:0005201	1/1184	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG83N9TJ	GO:0005581	1/1184	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG83N9TJ	GO:0050051	1/1184	leukotriene-B4 20-monooxygenase activity	molecular_function	"Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN]
EOG83N9TJ	GO:0052871	1/1184	alpha-tocopherol omega-hydroxylase activity	molecular_function	"Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003]
EOG83N9TJ	GO:0006629	1/1184	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG83N9TJ	GO:0005737	1/1184	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83N9TJ	GO:0005811	1/1184	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG84XMZ2	GO:0004602	43/144	glutathione peroxidase activity	molecular_function	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9]
EOG84XMZ2	GO:0006979	43/144	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG84XMZ2	GO:0005794	1/144	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG84XMZ2	GO:0005615	1/144	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG84XMZ2	GO:0047066	1/144	phospholipid-hydroperoxide glutathione peroxidase activity	molecular_function	"Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione." [EC:1.11.1.12, MetaCyc:1.11.1.12-RXN]
EOG84XMZ2	GO:0032504	1/144	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG84XMZ2	GO:0004601	1/144	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG83N9TS	GO:0016021	1/63	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83N9TS	GO:0017080	1/63	sodium channel regulator activity	molecular_function	"Modulates the activity of a sodium channel." [GOC:mah]
EOG83N9TS	GO:0002028	1/63	regulation of sodium ion transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph]
EOG8Z38VB	GO:0016020	41/234	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Z38VB	GO:0008654	41/234	phospholipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8Z38VB	GO:0003841	41/234	1-acylglycerol-3-phosphate O-acyltransferase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51, GOC:ab]
EOG8Z38VB	GO:0016746	6/234	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8Z38VB	GO:0048149	1/234	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8XWJBJ	GO:0005198	1/34	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8QFZTJ	GO:0008234	32/101	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8QFZTJ	GO:0005215	2/101	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8QFZTJ	GO:0005576	2/101	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8QFZTJ	GO:0005875	1/101	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8QFZTJ	GO:0005811	1/101	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8STVJK	GO:0005634	36/106	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8STVJK	GO:0003677	34/106	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8STVJK	GO:0008270	34/106	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8STVJK	GO:0018024	34/106	histone-lysine N-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]
EOG8STVJK	GO:0005694	30/106	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8STVJK	GO:0008168	2/106	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8STVJK	GO:0051038	2/106	negative regulation of transcription during meiosis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription during meiosis." [GOC:ai]
EOG8STVJK	GO:0006351	2/106	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8STVJK	GO:0048477	2/106	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8STVJK	GO:0035220	1/106	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8STVJK	GO:0060968	1/106	regulation of gene silencing	biological_process	"Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb]
EOG8STVJK	GO:0051567	1/106	histone H3-K9 methylation	biological_process	"The modification of histone H3 by addition of a methyl group to lysine at position 9 of the histone." [GOC:ai]
EOG8STVJK	GO:0007275	1/106	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8STVJK	GO:0040029	1/106	regulation of gene expression, epigenetic	biological_process	"Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [PMID:10521337, PMID:11498582]
EOG8STVJK	GO:0044026	1/106	DNA hypermethylation	biological_process	"An increase in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/]
EOG8STVJK	GO:0005700	1/106	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8STVJK	GO:0005737	1/106	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8STVJK	GO:0045814	1/106	negative regulation of gene expression, epigenetic	biological_process	"Any epigenetic process that stops, prevents or reduces the rate of gene expression." [GOC:go_curators]
EOG8STVJK	GO:0010385	1/106	double-stranded methylated DNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks." [GOC:imk, PMID:17242155]
EOG8STVJK	GO:0048132	1/106	female germ-line stem cell asymmetric division	biological_process	"The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu]
EOG8STVJK	GO:0002165	1/106	instar larval or pupal development	biological_process	"The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
EOG8STVJK	GO:0005515	1/106	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8STVJK	GO:0045892	1/106	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8STVJK	GO:0046974	1/106	histone methyltransferase activity (H3-K9 specific)	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein." [GOC:ai]
EOG8QFZTN	GO:0007165	1/7	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG82NMG9	GO:0005509	105/381	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG82NMG9	GO:0043565	1/381	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG82NMG9	GO:0032440	1/381	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG82NMG9	GO:0003700	1/381	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z653R	GO:0016192	26/83	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8Z653R	GO:0016020	25/83	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Z653R	GO:0006886	9/83	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8Z653R	GO:0005484	1/83	SNAP receptor activity	molecular_function	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
EOG8Z653R	GO:0035088	1/83	establishment or maintenance of apical/basal cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483]
EOG8Z653R	GO:0007269	1/83	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8Z653R	GO:0005769	1/83	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG8Z653R	GO:0008285	1/83	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8Z653R	GO:0045807	1/83	positive regulation of endocytosis	biological_process	"Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators]
EOG8Z653R	GO:0035073	1/83	pupariation	biological_process	"The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
EOG8Z653R	GO:0005515	1/83	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8Z653R	GO:0035264	1/83	multicellular organism growth	biological_process	"The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb]
EOG8Z653R	GO:0034058	1/83	endosomal vesicle fusion	biological_process	"The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]
EOG8Z653R	GO:0016081	1/83	synaptic vesicle docking	biological_process	"The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342]
EOG8Z653R	GO:0005886	1/83	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8Z653R	GO:0048227	1/83	plasma membrane to endosome transport	biological_process	"Transport of a vesicle from the plasma membrane to the endosome." [GOC:jid]
EOG8STVJC	GO:0016787	1/147	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8STVJC	GO:0016905	1/147	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG8QFZTF	GO:0022008	1/96	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8STVJG	GO:0071203	28/94	WASH complex	cellular_component	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]
EOG8Z653J	GO:0005576	30/178	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Z653J	GO:0008270	1/178	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Z653J	GO:0004222	1/178	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8Z653J	GO:0031012	1/178	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8Z653K	GO:0005765	23/85	lysosomal membrane	cellular_component	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]
EOG8Z653K	GO:0016021	21/85	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z653K	GO:0051453	1/85	regulation of intracellular pH	biological_process	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]
EOG8Z653K	GO:0006979	1/85	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8Z653K	GO:0008340	1/85	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8Z653K	GO:0015809	1/85	arginine transport	biological_process	"The directed movement of arginine, 2-amino-5-guanidinopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
EOG8Z653K	GO:0046328	1/85	regulation of JNK cascade	biological_process	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8Z653K	GO:0007040	1/85	lysosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]
EOG8Z653K	GO:0031982	1/85	vesicle	cellular_component	"Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz]
EOG8Z653K	GO:0005770	1/85	late endosome	cellular_component	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
EOG8Z653K	GO:0008593	1/85	regulation of Notch signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8Z653K	GO:0031301	1/85	integral component of organelle membrane	cellular_component	"The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
EOG8Z653K	GO:0007034	1/85	vacuolar transport	biological_process	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]
EOG8Z653K	GO:0005764	1/85	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8RFP6J	GO:0055037	1/95	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG8RFP6J	GO:0005515	1/95	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8RFP6J	GO:0008582	1/95	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8RFP6J	GO:0007274	1/95	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8RFP6J	GO:0005737	1/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RFP6J	GO:0030833	1/95	regulation of actin filament polymerization	biological_process	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG8RFP6J	GO:0005543	1/95	phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8RFP6J	GO:0045886	1/95	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8RFP6J	GO:0008270	1/95	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KWN99	GO:0005524	71/292	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KWN99	GO:0004674	64/292	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8KWN99	GO:0004672	7/292	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8KWN99	GO:0004702	3/292	receptor signaling protein serine/threonine kinase activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah]
EOG8KWN99	GO:0005737	3/292	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8KWN99	GO:0006468	3/292	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8KWN99	GO:0023014	2/292	signal transduction by protein phosphorylation	biological_process	"A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling]
EOG8KWN99	GO:0005856	1/292	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8KWN99	GO:0007015	1/292	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8KWN99	GO:0007520	1/292	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG8KWN99	GO:0005912	1/292	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8KWN99	GO:0097482	1/292	muscle cell postsynaptic density	cellular_component	"A postsynaptic density that is part of a muscle cell." [GOC:pr]
EOG8KWN99	GO:0045887	1/292	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8KWN99	GO:0019991	1/292	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG8KWN99	GO:0045315	1/292	positive regulation of compound eye photoreceptor development	biological_process	"Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
EOG8KWN99	GO:0007010	1/292	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8KWN99	GO:0007254	1/292	JNK cascade	biological_process	"An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974]
EOG8KWN99	GO:0005913	1/292	cell-cell adherens junction	cellular_component	"An adherens junction which connects a cell to another cell." [GOC:hb]
EOG8KWN99	GO:0008360	1/292	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8KWN99	GO:0000187	1/292	activation of MAPK activity	biological_process	"The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267]
EOG8KWN99	GO:0046331	1/292	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8KWN99	GO:0007391	1/292	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8KWN99	GO:0016601	1/292	Rac protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state." [GOC:bf]
EOG8KWN99	GO:0007411	1/292	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8KWN99	GO:0050803	1/292	regulation of synapse structure or activity	biological_process	"Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]
EOG8KWN99	GO:0005886	1/292	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8KWN99	GO:0016328	1/292	lateral plasma membrane	cellular_component	"The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr]
EOG8KWN99	GO:0048749	1/292	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8KWN99	GO:0005515	1/292	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KWN99	GO:0005925	1/292	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8KWN99	GO:0016319	1/292	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8KWN99	GO:0007030	1/292	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8KWN99	GO:0007409	1/292	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8KWN99	GO:0007155	1/292	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8KWN99	GO:0030036	1/292	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8KWN99	GO:0050770	1/292	regulation of axonogenesis	biological_process	"Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]
EOG8KWN99	GO:0045792	1/292	negative regulation of cell size	biological_process	"Any process that reduces cell size." [GOC:go_curators]
EOG8KWN99	GO:0001751	1/292	compound eye photoreceptor cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
EOG8RFP6F	GO:0005524	26/99	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8RFP6F	GO:0035091	26/99	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG8RFP6F	GO:0048015	26/99	phosphatidylinositol-mediated signaling	biological_process	"A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]
EOG8RFP6F	GO:0046854	23/99	phosphatidylinositol phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]
EOG8RFP6F	GO:0016773	22/99	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8RFP6F	GO:0016301	22/99	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8RFP6F	GO:0035005	4/99	1-phosphatidylinositol-4-phosphate 3-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.154, RHEA:18376]
EOG8RFP6F	GO:0005543	1/99	phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8RFP6F	GO:0010008	1/99	endosome membrane	cellular_component	"The lipid bilayer surrounding an endosome." [GOC:mah]
EOG8RFP6F	GO:0006974	1/99	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8RFP6F	GO:0016303	1/99	1-phosphatidylinositol-3-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.137, RHEA:12712]
EOG8RFP6F	GO:0017137	1/99	Rab GTPase binding	molecular_function	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG8RFP6F	GO:0005942	1/99	phosphatidylinositol 3-kinase complex	cellular_component	"A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too." [GOC:bf, PMID:24587488]
EOG8RFP6F	GO:0005886	1/99	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8RFP6F	GO:0036092	1/99	phosphatidylinositol-3-phosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position." [CHEBI:26034, GOC:al, GOC:vw]
EOG8RFP6F	GO:0035004	1/99	phosphatidylinositol 3-kinase activity	molecular_function	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring." [GOC:bf, PMID:10209156, PMID:9255069]
EOG8RFP6F	GO:0005515	1/99	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8RFP6F	GO:0030866	1/99	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8RFP6F	GO:0006909	1/99	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG82JR7B	GO:0006281	24/83	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG82JR7B	GO:0030915	24/83	Smc5-Smc6 complex	cellular_component	"A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739]
EOG82JR7B	GO:0008270	16/83	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG82JR7B	GO:0035556	15/83	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG82JR7B	GO:0016567	1/83	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG82JR7B	GO:0004842	1/83	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG82JR7B	GO:0005634	1/83	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82JR7B	GO:0006310	1/83	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG82JR7B	GO:0046872	1/83	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82JR7B	GO:2001022	1/83	positive regulation of response to DNA damage stimulus	biological_process	"Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
EOG8CVJNS	GO:0000226	1/105	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8CVJNS	GO:0003735	1/105	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8CVJNS	GO:0045169	1/105	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG8CVJNS	GO:0043186	1/105	P granule	cellular_component	"A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
EOG8CVJNS	GO:0005840	1/105	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8CVJNS	GO:0030036	1/105	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8CVJNS	GO:0006412	1/105	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8CVJNS	GO:0005875	1/105	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8CVJNS	GO:0005515	1/105	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8Z653G	GO:0046872	43/145	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z653G	GO:0003676	43/145	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Z653G	GO:0005634	42/145	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z653G	GO:0003700	41/145	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z653G	GO:0006351	41/145	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8Z653G	GO:0000981	1/145	RNA polymerase II transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
EOG8Z653G	GO:0006909	1/145	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8Z653G	GO:0031935	1/145	regulation of chromatin silencing	biological_process	"Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah]
EOG8Z653G	GO:0007476	1/145	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8Z653G	GO:0006366	1/145	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8Z653G	GO:0006357	1/145	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG808QRV	GO:0003677	3/4	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81RSBH	GO:0006546	1/4	glycine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]
EOG81RSBH	GO:0004375	1/4	glycine dehydrogenase (decarboxylating) activity	molecular_function	"Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2]
EOG8W10VF	GO:0004871	2/90	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8W10VF	GO:0005886	2/90	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8W10VF	GO:0005070	2/90	SH3/SH2 adaptor activity	molecular_function	"Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68)." [GOC:mah, GOC:so]
EOG8W10VF	GO:0038202	1/90	TORC1 signaling	biological_process	"A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]
EOG8W10VF	GO:0008360	1/90	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8W10VF	GO:0009967	1/90	positive regulation of signal transduction	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]
EOG8W10VF	GO:0007175	1/90	negative regulation of epidermal growth factor-activated receptor activity	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators]
EOG8W10VF	GO:0007476	1/90	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8W10VF	GO:0008595	1/90	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8W10VF	GO:0007256	1/90	activation of JNKK activity	biological_process	"The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549]
EOG8W10VF	GO:0008293	1/90	torso signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
EOG8W10VF	GO:0007614	1/90	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8W10VF	GO:0043410	1/90	positive regulation of MAPK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]
EOG8W10VF	GO:0005118	1/90	sevenless binding	molecular_function	"Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:3151175]
EOG8W10VF	GO:0007265	1/90	Ras protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf]
EOG8W10VF	GO:0007015	1/90	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8W10VF	GO:0045678	1/90	positive regulation of R7 cell differentiation	biological_process	"Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8W10VF	GO:0001700	1/90	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8W10VF	GO:0008355	1/90	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8W10VF	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8W10VF	GO:0008306	1/90	associative learning	biological_process	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
EOG8W10VF	GO:0045500	1/90	sevenless signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:10771085]
EOG81RSBK	GO:0045454	76/199	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG81RSBK	GO:0006662	76/199	glycerol ether metabolic process	biological_process	"The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732]
EOG81RSBK	GO:0015035	76/199	protein disulfide oxidoreductase activity	molecular_function	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]
EOG81RSBK	GO:0006974	3/199	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG81RSBK	GO:0005634	2/199	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81RSBK	GO:0019594	1/199	mannitol metabolic process	biological_process	"The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732]
EOG81RSBK	GO:0006457	1/199	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG81RSBK	GO:0016853	1/199	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG81RSBK	GO:0006281	1/199	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG81RSBK	GO:0016491	1/199	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG81RSBK	GO:0006979	1/199	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG81RSBK	GO:0050832	1/199	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG81RSBK	GO:0008340	1/199	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG81RSBK	GO:0030915	1/199	Smc5-Smc6 complex	cellular_component	"A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739]
EOG81RSBK	GO:0015036	1/199	disulfide oxidoreductase activity	molecular_function	"Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]
EOG81RSBK	GO:0003756	1/199	protein disulfide isomerase activity	molecular_function	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1]
EOG81RSBK	GO:0055114	1/199	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG81RSBK	GO:0000806	1/199	Y chromosome	cellular_component	"The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males." [GOC:mah, ISBN:0582227089]
EOG89CSQD	GO:0016597	1/69	amino acid binding	molecular_function	"Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]
EOG89CSQD	GO:0002121	1/69	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG89CSQD	GO:0042332	1/69	gravitaxis	biological_process	"The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
EOG89CSQD	GO:0008152	1/69	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8W10VC	GO:0008270	21/102	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8W10VC	GO:0003700	20/102	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8W10VC	GO:0005634	20/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8W10VC	GO:0043565	20/102	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8W10VC	GO:0016740	2/102	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8W10VC	GO:0045892	1/102	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8W10VC	GO:0045893	1/102	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8W10VC	GO:0010468	1/102	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8W10VC	GO:0003677	1/102	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8W10VC	GO:0007479	1/102	leg disc proximal/distal pattern formation	biological_process	"The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf]
EOG8W10VC	GO:0007480	1/102	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8W10VC	GO:0048749	1/102	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG87H83X	GO:0005524	27/105	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87H83X	GO:0004697	27/105	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG87H83X	GO:0035556	25/105	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG87H83X	GO:0046872	24/105	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG87H83X	GO:0005737	12/105	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87H83X	GO:0004674	1/105	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG87H83X	GO:0006468	1/105	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8BK7KW	GO:0046872	1/11	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8H48HK	GO:0003950	24/98	NAD+ ADP-ribosyltransferase activity	molecular_function	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]
EOG8H48HK	GO:0032440	2/98	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8H48HK	GO:0005515	1/98	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8H48HK	GO:0022416	1/98	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8H48HK	GO:0005634	1/98	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8H48HK	GO:0003700	1/98	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8H48HK	GO:0016055	1/98	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG8H48HK	GO:0090364	1/98	regulation of proteasome assembly	biological_process	"Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:dph, GOC:elh, GOC:tb]
EOG8H48HK	GO:0043565	1/98	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8H48HK	GO:0006471	1/98	protein ADP-ribosylation	biological_process	"The transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:pr, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295]
EOG8H48HK	GO:0032212	1/98	positive regulation of telomere maintenance via telomerase	biological_process	"Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]
EOG8H48HK	GO:0004623	1/98	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG8H48HK	GO:0035220	1/98	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8H48HK	GO:0051225	1/98	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG8H48HH	GO:0009235	4/153	cobalamin metabolic process	biological_process	"The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators]
EOG8H48HH	GO:0005739	4/153	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8H48HH	GO:0048488	1/153	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8H48HH	GO:0030036	1/153	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8BK7KT	GO:0008615	5/32	pyridoxine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds." [GOC:ai]
EOG8BK7KT	GO:0004733	5/32	pyridoxamine-phosphate oxidase activity	molecular_function	"Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide." [EC:1.4.3.5]
EOG8BK7KT	GO:0010181	5/32	FMN binding	molecular_function	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]
EOG89CSQT	GO:0003677	1/129	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG89CSQT	GO:0006726	1/129	eye pigment biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
EOG89CSQT	GO:0008270	1/129	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8H48HM	GO:0004190	2/90	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8H48HM	GO:0032440	1/90	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8W6RCD	GO:0031083	1/51	BLOC-1 complex	cellular_component	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]
EOG822D1C	GO:0042623	1/150	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG822D1C	GO:0030286	1/150	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG822D1C	GO:0006200	1/150	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG822D1C	GO:0007018	1/150	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG869T8K	GO:0016021	1/16	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BK7K6	GO:0019354	2/8	siroheme biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732]
EOG8BK7K6	GO:0043115	2/8	precorrin-2 dehydrogenase activity	molecular_function	"Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin." [EC:1.3.1.76, RHEA:15616]
EOG8BK7K6	GO:0008168	1/8	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8BK7K6	GO:0004851	1/8	uroporphyrin-III C-methyltransferase activity	molecular_function	"Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2." [EC:2.1.1.107]
EOG8BK7K6	GO:0051287	1/8	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8BK7K6	GO:0051266	1/8	sirohydrochlorin ferrochelatase activity	molecular_function	"Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin." [EC:4.99.1.4, RHEA:24363]
EOG8BK7K6	GO:0009236	1/8	cobalamin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:jl, ISBN:0198506732]
EOG8BK7K5	GO:0003723	83/200	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8BK7K5	GO:0016607	4/200	nuclear speck	cellular_component	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]
EOG8BK7K5	GO:0005737	1/200	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8BK7K5	GO:0071013	1/200	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8BK7K5	GO:0000398	1/200	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8BK7K5	GO:0005634	1/200	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BK7K5	GO:0000381	1/200	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8BK7K5	GO:0022008	1/200	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8BK7K5	GO:0071011	1/200	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8BK7K5	GO:0006915	1/200	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8BK7K5	GO:0007288	1/200	sperm axoneme assembly	biological_process	"The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, ISBN:0198547684]
EOG8BK7K5	GO:0010608	1/200	posttranscriptional regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]
EOG8BK7K5	GO:0046331	1/200	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8BK7K5	GO:0007291	1/200	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8SBHBV	GO:0005524	24/88	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SBHBV	GO:0042623	23/88	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8SBHBV	GO:0005778	23/88	peroxisomal membrane	cellular_component	"The lipid bilayer surrounding a peroxisome." [GOC:mah]
EOG8SBHBV	GO:0006625	23/88	protein targeting to peroxisome	biological_process	"The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai]
EOG8SBHBV	GO:0007031	2/88	peroxisome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
EOG8SBHBV	GO:0004672	2/88	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8SBHBV	GO:0021782	1/88	glial cell development	biological_process	"The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8SBHBV	GO:0017111	1/88	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8SBHBV	GO:0007422	1/88	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8SBHBV	GO:0004713	1/88	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8SBHBV	GO:0016021	1/88	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SBHBV	GO:0048137	1/88	spermatocyte division	biological_process	"The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238]
EOG8SBHBV	GO:0007417	1/88	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8SBHBV	GO:0005777	1/88	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8W10V0	GO:0005975	167/551	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8W10V0	GO:0006032	166/551	chitin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8W10V0	GO:0004568	166/551	chitinase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
EOG8W10V0	GO:0008061	105/551	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8W10V0	GO:0005576	104/551	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8W10V0	GO:0006030	4/551	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8W10V0	GO:0016021	3/551	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W10V0	GO:0004553	3/551	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8W10V0	GO:0005615	2/551	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8W10V0	GO:0000272	2/551	polysaccharide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:go_curators]
EOG8X9B00	GO:0051491	1/108	positive regulation of filopodium assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG8X9B00	GO:0005515	1/108	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8X9B00	GO:0051286	1/108	cell tip	cellular_component	"The region at either end of the longest axis of a cylindrical or elongated cell." [GOC:ai, GOC:mah]
EOG8X9B00	GO:0016203	1/108	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8X9B00	GO:0007517	1/108	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8X9B00	GO:0022008	1/108	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG82JR79	GO:0003700	24/73	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG82JR79	GO:0043565	24/73	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG82JR79	GO:0005634	22/73	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82JR79	GO:0007275	14/73	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG82JR79	GO:0001748	1/73	optic lobe placode development	biological_process	"The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833]
EOG82JR79	GO:0004000	1/73	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8Z6538	GO:0004046	96/196	aminoacylase activity	molecular_function	"Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14]
EOG8Z6538	GO:0006520	96/196	cellular amino acid metabolic process	biological_process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]
EOG8Z6538	GO:0005737	96/196	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Z6538	GO:0008237	53/196	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8Z6538	GO:0016787	4/196	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8Z6538	GO:0004180	1/196	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8S7N3W	GO:0016021	27/114	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S7N3W	GO:0008026	1/114	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8S7N3W	GO:0005524	1/114	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8S7N3W	GO:0003676	1/114	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8S7N3T	GO:0050660	27/119	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8S7N3T	GO:0008762	26/119	UDP-N-acetylmuramate dehydrogenase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158]
EOG8S7N3T	GO:0009055	25/119	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8S7N3T	GO:0051537	25/119	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8S7N3T	GO:0004855	23/119	xanthine oxidase activity	molecular_function	"Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide." [EC:1.17.3.2]
EOG8S7N3T	GO:0043546	23/119	molybdopterin cofactor binding	molecular_function	"Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]
EOG8S7N3T	GO:0004854	23/119	xanthine dehydrogenase activity	molecular_function	"Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+." [EC:1.17.1.4]
EOG8S7N3T	GO:0005506	22/119	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8S7N3T	GO:0046872	4/119	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8S7N3T	GO:0016491	3/119	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8S7N3T	GO:0009115	2/119	xanthine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators]
EOG8S7N3T	GO:0005777	2/119	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8S7N3T	GO:0030151	2/119	molybdenum ion binding	molecular_function	"Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai]
EOG8S7N3T	GO:0006568	1/119	tryptophan metabolic process	biological_process	"The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684]
EOG8S7N3T	GO:0008340	1/119	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8S7N3T	GO:0005875	1/119	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8S7N3T	GO:0006206	1/119	pyrimidine nucleobase metabolic process	biological_process	"The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [CHEBI:26432, GOC:go_curators]
EOG8S7N3T	GO:0006144	1/119	purine nucleobase metabolic process	biological_process	"The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [CHEBI:26386, GOC:go_curators]
EOG8S7N3T	GO:0018492	1/119	carbon-monoxide dehydrogenase (acceptor) activity	molecular_function	"Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.99.2]
EOG8S7N3T	GO:0048072	1/119	compound eye pigmentation	biological_process	"Establishment of a pattern of pigment in the compound eye." [GOC:jid]
EOG8S7N3T	GO:0006525	1/119	arginine metabolic process	biological_process	"The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators]
EOG8S7N3T	GO:0016614	1/119	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8S7N3T	GO:0006650	1/119	glycerophospholipid metabolic process	biological_process	"The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]
EOG8WSZVH	GO:0004222	1/2	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8WSZVH	GO:0016020	1/2	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8N8TNQ	GO:0016020	2/6	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82VBZM	GO:0046658	1/59	anchored component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG82VBZM	GO:0046928	1/59	regulation of neurotransmitter secretion	biological_process	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
EOG8CVJN2	GO:0005524	25/94	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CVJN2	GO:0004674	21/94	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8CVJN2	GO:0004693	2/94	cyclin-dependent protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]
EOG8CVJN2	GO:0004672	2/94	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8CVJN2	GO:0006468	1/94	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8CVJN2	GO:0042302	1/94	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8QFZT5	GO:0016021	40/173	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QFZT5	GO:0055085	40/173	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8QFZT5	GO:0003824	1/173	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8CVJN0	GO:0005089	20/94	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8CVJN0	GO:0030833	1/94	regulation of actin filament polymerization	biological_process	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG8CVJN0	GO:0005544	1/94	calcium-dependent phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]
EOG8CVJN0	GO:1900029	1/94	positive regulation of ruffle assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf]
EOG8CVJN0	GO:0032319	1/94	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8CVJN0	GO:0016319	1/94	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8CVJN0	GO:0035022	1/94	positive regulation of Rac protein signal transduction	biological_process	"Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction." [GOC:bf]
EOG8CVJN0	GO:0005622	1/94	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG82589B	GO:0008270	1/20	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG82589B	GO:0003735	1/20	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG82589B	GO:0003676	1/20	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82589B	GO:0006412	1/20	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG82589B	GO:0015935	1/20	small ribosomal subunit	cellular_component	"The smaller of the two subunits of a ribosome." [GOC:mah]
EOG80P6PC	GO:0004030	37/289	aldehyde dehydrogenase [NAD(P)+] activity	molecular_function	"Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5]
EOG80P6PC	GO:0006081	36/289	cellular aldehyde metabolic process	biological_process	"The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732]
EOG80P6PC	GO:0005975	28/289	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG80P6PC	GO:0005840	26/289	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG80P6PC	GO:0006412	26/289	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG80P6PC	GO:0003735	26/289	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG80P6PC	GO:0016773	26/289	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG80P6PC	GO:0016301	22/289	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG80P6PC	GO:0004370	2/289	glycerol kinase activity	molecular_function	"Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21647]
EOG80P6PC	GO:0005811	1/289	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG80P6PC	GO:0000022	1/289	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG80P6PC	GO:0007052	1/289	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG80P6PC	GO:0007264	1/289	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG80P6PC	GO:0016491	1/289	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG80P6PC	GO:0005525	1/289	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG80P6PC	GO:0005622	1/289	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG80P6PC	GO:0016020	1/289	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG89PDCB	GO:0008270	20/108	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG89PDCB	GO:0003682	1/108	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG89PDCB	GO:0005669	1/108	transcription factor TFIID complex	cellular_component	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]
EOG89PDCB	GO:0003677	1/108	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG89PDCB	GO:0008134	1/108	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG89PDCB	GO:0005634	1/108	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG89PDCB	GO:0005515	1/108	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG89PDCB	GO:0017176	1/108	phosphatidylinositol N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]
EOG89PDCB	GO:0031208	1/108	POZ domain binding	molecular_function	"Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847]
EOG89PDCB	GO:0045944	1/108	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG89PDCB	GO:0002039	1/108	p53 binding	molecular_function	"Interacting selectively and non-covalently with one of the p53 family of proteins." [GOC:hjd]
EOG8DNHMH	GO:0003755	24/89	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8DNHMH	GO:0006457	24/89	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8DNHMH	GO:0000412	18/89	histone peptidyl-prolyl isomerization	biological_process	"The modification of a histone by cis-trans isomerization of a proline residue." [GOC:krc]
EOG8DNHMH	GO:0005730	18/89	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8DNHMH	GO:0005528	18/89	FK506 binding	molecular_function	"Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506." [GOC:jl]
EOG8DNHMH	GO:0018208	1/89	peptidyl-proline modification	biological_process	"The modification of peptidyl-proline." [GOC:go_curators]
EOG8DNHMH	GO:0035626	1/89	juvenile hormone mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of juvenile hormone to a receptor, and ending with regulation of cell state or activity." [GOC:bf, GOC:sart]
EOG8DNHMH	GO:0070594	1/89	juvenile hormone response element binding	molecular_function	"Interacting selectively and non-covalently with the juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone." [GOC:sart, PMID:17956872]
EOG8DNHMH	GO:0005515	1/89	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8DNHMH	GO:0016242	1/89	negative regulation of macroautophagy	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]
EOG8DNHMH	GO:0005875	1/89	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8DNHMH	GO:0010507	1/89	negative regulation of autophagy	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8DNHMH	GO:0016020	1/89	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82RGNG	GO:0016746	2/166	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG82RGNG	GO:0050832	1/166	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG82RGNG	GO:0007527	1/166	adult somatic muscle development	biological_process	"The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG82RGNG	GO:0072686	1/166	mitotic spindle	cellular_component	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
EOG8DNHMX	GO:0019185	1/127	snRNA-activating protein complex	cellular_component	"A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788]
EOG8DNHMX	GO:0007304	1/127	chorion-containing eggshell formation	biological_process	"The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8DNHMX	GO:0007275	1/127	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8DNHMX	GO:0043565	1/127	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8DNHMX	GO:0042600	1/127	chorion	cellular_component	"A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
EOG8DNHMX	GO:0005213	1/127	structural constituent of chorion	molecular_function	"The action of a molecule that contributes to the structural integrity of a chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu]
EOG8DNHMX	GO:0042796	1/127	snRNA transcription from RNA polymerase III promoter	biological_process	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]
EOG8DNHMX	GO:0065004	1/127	protein-DNA complex assembly	biological_process	"The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl]
EOG8DNHMX	GO:0003681	1/127	bent DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA in a bent conformation." [GOC:jl, PMID:12627977]
EOG8DNHMX	GO:0042795	1/127	snRNA transcription from RNA polymerase II promoter	biological_process	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382]
EOG8DNHMX	GO:0003677	1/127	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DNHMX	GO:0005515	1/127	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8G7FCT	GO:0003676	104/318	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8G7FCT	GO:0016747	1/318	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8G7FCT	GO:0046872	1/318	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8G7FCS	GO:0050909	12/64	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8G7FCS	GO:0005886	12/64	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8G7FCS	GO:0016021	12/64	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G7FCR	GO:0005975	35/112	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8G7FCR	GO:0004553	34/112	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8G7FCR	GO:0032450	1/112	maltose alpha-glucosidase activity	molecular_function	"Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141]
EOG81C99D	GO:0004366	14/97	glycerol-3-phosphate O-acyltransferase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.15]
EOG81C99D	GO:0005886	12/97	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG81C99D	GO:0008654	12/97	phospholipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG81C99D	GO:0044255	11/97	cellular lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]
EOG81C99D	GO:0008374	9/97	O-acyltransferase activity	molecular_function	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
EOG81C99D	GO:0034587	1/97	piRNA metabolic process	biological_process	"The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]
EOG81C99D	GO:0045169	1/97	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG81C99D	GO:0035324	1/97	female germline ring canal	cellular_component	"An intercellular bridge that connects the germline cells of a female cyst." [PMID:9635420]
EOG81C99D	GO:0005739	1/97	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG81C99D	GO:0016746	1/97	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG81C99D	GO:0005783	1/97	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8NCPV8	GO:0016021	56/128	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NCPV8	GO:0005525	1/128	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8NCPV8	GO:0003746	1/128	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG82C0PP	GO:0005272	34/119	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG82C0PP	GO:0016021	32/119	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82C0PP	GO:0016020	2/119	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8MSGFK	GO:0006397	22/78	mRNA processing	biological_process	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]
EOG8MSGFK	GO:0071013	1/78	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8MSGFK	GO:0005634	1/78	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8MSGFK	GO:0000398	1/78	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8MSGFK	GO:0005688	1/78	U6 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U6." [GOC:krc, GOC:mah]
EOG8MSGFK	GO:0030532	1/78	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8MSGFK	GO:0005681	1/78	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8MSGFK	GO:0022008	1/78	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8MSGFK	GO:0071011	1/78	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8MSGFK	GO:0000381	1/78	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8G7FCB	GO:0016021	42/190	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G7FCB	GO:0008271	30/190	secondary active sulfate transmembrane transporter activity	molecular_function	"Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
EOG8G7FCB	GO:0015116	13/190	sulfate transmembrane transporter activity	molecular_function	"Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai]
EOG8G7FCB	GO:0005452	1/190	inorganic anion exchanger activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah]
EOG8G7FCB	GO:1902358	1/190	sulfate transmembrane transport	biological_process	"The directed movement of sulfate across a membrane." [GOC:dph, GOC:TermGenie, PMID:9055073]
EOG8G7FCB	GO:0015106	1/190	bicarbonate transmembrane transporter activity	molecular_function	"Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai]
EOG8G7FCB	GO:0008272	1/190	sulfate transport	biological_process	"The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8G7FCB	GO:0019532	1/190	oxalate transport	biological_process	"The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732]
EOG8G7FCB	GO:0015724	1/190	formate transport	biological_process	"The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8G7FCB	GO:0015085	1/190	calcium ion transmembrane transporter activity	molecular_function	"Enables the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:dgf]
EOG8G7FCB	GO:0070588	1/190	calcium ion transmembrane transport	biological_process	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8G7FCB	GO:0015499	1/190	formate transmembrane transporter activity	molecular_function	"Enables the transfer of formate from one side of the membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [GOC:ai]
EOG8G7FCB	GO:0019531	1/190	oxalate transmembrane transporter activity	molecular_function	"Enables the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732]
EOG8G7FCB	GO:0015701	1/190	bicarbonate transport	biological_process	"The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8NCPVS	GO:0007010	25/82	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8NCPVS	GO:0005737	24/82	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8NCPVS	GO:0005829	1/82	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8NCPVS	GO:0007420	1/82	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG8NCPVS	GO:0003785	1/82	actin monomer binding	molecular_function	"Interacting selectively and non-covalently with monomeric actin, also known as G-actin." [GOC:ai]
EOG8NCPVS	GO:0003779	1/82	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8NCPVS	GO:0035193	1/82	larval central nervous system remodeling	biological_process	"Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster." [GOC:sensu, PMID:9647692]
EOG8NCPVR	GO:0004518	1/47	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8NCPVR	GO:0006281	1/47	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8NCPVV	GO:0005743	30/183	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8NCPVV	GO:0004129	30/183	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8NCPVV	GO:0016020	5/183	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NCPVV	GO:0016192	4/183	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8NCPVV	GO:0006886	3/183	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8NCPVV	GO:0046872	2/183	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NCPVV	GO:0005938	1/183	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8NCPVV	GO:0031594	1/183	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8NCPVV	GO:0003676	1/183	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NCPVV	GO:0045787	1/183	positive regulation of cell cycle	biological_process	"Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators]
EOG8NCPVV	GO:0007274	1/183	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8NCPVV	GO:0005739	1/183	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8NCPVV	GO:0007528	1/183	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8NCPVV	GO:0005811	1/183	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8NCPVV	GO:0005484	1/183	SNAP receptor activity	molecular_function	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
EOG8M3CRM	GO:0006030	1/386	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8M3CRM	GO:0008010	1/386	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8M3CRM	GO:0005578	1/386	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG8M3CRM	GO:0005576	1/386	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8M3CRM	GO:0008061	1/386	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8M3CRM	GO:0040003	1/386	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8M3CRM	GO:0022008	1/386	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8ZW7QX	GO:0006888	24/97	ER to Golgi vesicle-mediated transport	biological_process	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]
EOG8ZW7QX	GO:0008270	24/97	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZW7QX	GO:0030127	24/97	COPII vesicle coat	cellular_component	"One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]
EOG8ZW7QX	GO:0006886	24/97	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8ZW7QX	GO:0016021	1/97	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZW7QX	GO:0035151	1/97	regulation of tube size, open tracheal system	biological_process	"Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]
EOG8ZW7QX	GO:0007030	1/97	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8ZW7QX	GO:0007157	1/97	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]
EOG8ZW7QX	GO:0022409	1/97	positive regulation of cell-cell adhesion	biological_process	"Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
EOG8ZW7QX	GO:0006511	1/97	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8ZW7QX	GO:0009306	1/97	protein secretion	biological_process	"The controlled release of proteins from a cell." [GOC:ai]
EOG8ZW7QX	GO:0040003	1/97	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8ZW7QX	GO:0007029	1/97	endoplasmic reticulum organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
EOG8ZW7QX	GO:0000902	1/97	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8ZW7QX	GO:0004674	1/97	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8ZW7QX	GO:0005524	1/97	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZW7QX	GO:0005811	1/97	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8ZW7QX	GO:0070403	1/97	NAD+ binding	molecular_function	"Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
EOG8ZW7QX	GO:0048081	1/97	positive regulation of cuticle pigmentation	biological_process	"Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
EOG8ZW7QX	GO:0070971	1/97	endoplasmic reticulum exit site	cellular_component	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]
EOG8ZW7QX	GO:0006457	1/97	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8ZW7QX	GO:0035158	1/97	regulation of tube diameter, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584]
EOG8ZW7QX	GO:0008360	1/97	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8ZW7QX	GO:0003331	1/97	positive regulation of extracellular matrix constituent secretion	biological_process	"Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
EOG8ZW7QX	GO:0016203	1/97	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8ZW7QX	GO:0009405	1/97	pathogenesis	biological_process	"The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators]
EOG8ZW7QX	GO:0034394	1/97	protein localization to cell surface	biological_process	"A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah]
EOG8ZW7QX	GO:0071711	1/97	basement membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah]
EOG8ZW7QX	GO:0003755	1/97	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8ZW7QX	GO:0030011	1/97	maintenance of cell polarity	biological_process	"The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8ZW7QX	GO:0035149	1/97	lumen formation, open tracheal system	biological_process	"Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
EOG8MSGF5	GO:0016972	28/88	thiol oxidase activity	molecular_function	"Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O." [EC:1.8.3.2]
EOG8MSGF5	GO:0016209	1/88	antioxidant activity	molecular_function	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
EOG8MSGF5	GO:0051726	1/88	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8MSGF5	GO:0042246	1/88	tissue regeneration	biological_process	"The regrowth of lost or destroyed tissues." [GOC:curators]
EOG8HQH2B	GO:0003964	3/11	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8HQH2B	GO:0003723	3/11	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8HQH2B	GO:0015074	1/11	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8HQH2B	GO:0004523	1/11	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG81C997	GO:0006486	50/178	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG81C997	GO:0016020	49/178	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG81C997	GO:0004576	47/178	oligosaccharyl transferase activity	molecular_function	"Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
EOG81C997	GO:0004579	3/178	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	molecular_function	"Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119]
EOG81C997	GO:0008250	1/178	oligosaccharyltransferase complex	cellular_component	"A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected." [ISBN:0879695595, PMID:15835887]
EOG81C997	GO:0035220	1/178	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG81C997	GO:0022416	1/178	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8FBM8Z	GO:0005634	70/166	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FBM8Z	GO:0003682	3/166	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8FBM8Z	GO:0005515	2/166	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FBM8Z	GO:0008270	2/166	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FBM8Z	GO:0006355	2/166	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8FBM8Z	GO:0006351	2/166	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8FBM8Z	GO:0000792	2/166	heterochromatin	cellular_component	"A compact and highly condensed form of chromatin." [GOC:elh]
EOG8FBM8Z	GO:0031940	1/166	positive regulation of chromatin silencing at telomere	biological_process	"Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah]
EOG8FBM8Z	GO:0000122	1/166	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8FBM8Z	GO:0006342	1/166	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG8FBM8Z	GO:0042981	1/166	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8FBM8Z	GO:0006357	1/166	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8FBM8Z	GO:0005654	1/166	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG8FBM8Z	GO:0005694	1/166	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8FBM8Z	GO:0042393	1/166	histone binding	molecular_function	"Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl]
EOG8FBM8Z	GO:0045893	1/166	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8FBM8Z	GO:0005700	1/166	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8FBM8Z	GO:0016568	1/166	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG8FBM8Z	GO:0003729	1/166	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8FBM8Z	GO:0035064	1/166	methylated histone binding	molecular_function	"Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf, PMID:14585615]
EOG8FBM8Z	GO:0005703	1/166	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG8FBM8Z	GO:0022008	1/166	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8FBM8Z	GO:0035012	1/166	polytene chromosome, telomeric region	cellular_component	"The terminal region of a polytene chromosome." [GOC:bf]
EOG8FBM8Z	GO:0005705	1/166	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG8FBM8Z	GO:0045944	1/166	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8FBM8Z	GO:0031060	1/166	regulation of histone methylation	biological_process	"Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]
EOG8FBM8Z	GO:1900111	1/166	positive regulation of histone H3-K9 dimethylation	biological_process	"Any process that activates or increases the frequency, rate or extent of histone H3-K9 dimethylation." [GOC:TermGenie, GOC:vw]
EOG8FBM8Z	GO:0005701	1/166	polytene chromosome chromocenter	cellular_component	"A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012]
EOG8FBM8Z	GO:0000182	1/166	rDNA binding	molecular_function	"Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA." [GOC:mah]
EOG8FBM8Z	GO:0045892	1/166	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8FBM8Z	GO:0031452	1/166	negative regulation of heterochromatin assembly	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation." [GOC:mah]
EOG8FBM8Z	GO:0043234	1/166	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8FBM8Z	GO:0006343	1/166	establishment of chromatin silencing	biological_process	"The initial formation of a transcriptionally silent chromatin structure such as heterochromatin." [GOC:mah]
EOG8FBM8Z	GO:0003696	1/166	satellite DNA binding	molecular_function	"Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005]
EOG8FBM8Z	GO:0033697	1/166	positive regulation of extent of heterochromatin assembly	biological_process	"Any process that increases the extent of heterochromatin formation; increases the size of a chromosomal region converted to heterochromatin." [GOC:mah]
EOG8FBM8Z	GO:0034773	1/166	histone H4-K20 trimethylation	biological_process	"The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone." [GOC:mah]
EOG8FBM8Z	GO:0000780	1/166	condensed nuclear chromosome, centromeric region	cellular_component	"The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
EOG8FBM8Z	GO:0016458	1/166	gene silencing	biological_process	"Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb]
EOG8FBM8Z	GO:0030702	1/166	chromatin silencing at centromere	biological_process	"Repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:mah]
EOG8FBM8Z	GO:0005704	1/166	polytene chromosome band	cellular_component	"A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342]
EOG8FBM8Z	GO:0005720	1/166	nuclear heterochromatin	cellular_component	"A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732]
EOG8FBM8Z	GO:0051276	1/166	chromosome organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8FBM8Z	GO:0003677	1/166	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FBM8Z	GO:0000723	1/166	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8FBM8Z	GO:0000781	1/166	chromosome, telomeric region	cellular_component	"The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh]
EOG8FBM8Z	GO:0031507	1/166	heterochromatin assembly	biological_process	"The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent." [GOC:mah]
EOG8FBM8Z	GO:0000793	1/166	condensed chromosome	cellular_component	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]
EOG8FBM8Z	GO:0044026	1/166	DNA hypermethylation	biological_process	"An increase in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/]
EOG8FBM8Z	GO:0005721	1/166	pericentric heterochromatin	cellular_component	"Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [PMID:12019236, PMID:20206496, PMID:22729156]
EOG8FBM8Z	GO:0003676	1/166	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FBM8Z	GO:0000775	1/166	chromosome, centromeric region	cellular_component	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
EOG8FBM8Z	GO:0000791	1/166	euchromatin	cellular_component	"A dispersed and relatively uncompacted form of chromatin." [GOC:elh]
EOG8Z38TM	GO:0005737	1/107	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Z38TM	GO:0022008	1/107	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8Z38TM	GO:0000902	1/107	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8Z38TM	GO:0005783	1/107	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8JWXVD	GO:0004402	1/47	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG87WR2P	GO:0022417	1/51	protein maturation by protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein." [GOC:isa_complete]
EOG87WR2P	GO:0051082	1/51	unfolded protein binding	molecular_function	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]
EOG87WR2P	GO:0016021	1/51	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87WR2P	GO:0061077	1/51	chaperone-mediated protein folding	biological_process	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]
EOG84BDGD	GO:0017111	1/92	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG84BDGD	GO:0000166	1/92	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8JQ6DN	GO:0003964	6/36	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8JQ6DN	GO:0003723	6/36	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG87WR2G	GO:0016459	24/104	myosin complex	cellular_component	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
EOG87WR2G	GO:0005524	23/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87WR2G	GO:0003774	23/104	motor activity	molecular_function	"Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
EOG87WR2G	GO:0005856	5/104	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG87WR2G	GO:0030175	1/104	filopodium	cellular_component	"Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194]
EOG87WR2G	GO:0006886	1/104	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG87WR2G	GO:0042623	1/104	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG87WR2G	GO:0043025	1/104	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG87WR2G	GO:0046847	1/104	filopodium assembly	biological_process	"The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790]
EOG87WR2G	GO:0006200	1/104	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG87WR2G	GO:0005515	1/104	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG87WR2G	GO:0007391	1/104	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG80P6P5	GO:0005525	51/170	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG80P6P5	GO:0007264	51/170	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG80P6P5	GO:0015031	46/170	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG80P6P5	GO:0004767	3/170	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG80P6P5	GO:0005770	2/170	late endosome	cellular_component	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
EOG80P6P5	GO:0003924	2/170	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG80P6P5	GO:0006184	2/170	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG80P6P5	GO:0045202	2/170	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG80P6P5	GO:0048190	1/170	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG80P6P5	GO:0005811	1/170	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG80P6P5	GO:0032510	1/170	endosome to lysosome transport via multivesicular body sorting pathway	biological_process	"The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:mah, PMID:12461556, PMID:16689637]
EOG80P6P5	GO:0033227	1/170	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG80P6P5	GO:0008333	1/170	endosome to lysosome transport	biological_process	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]
EOG80P6P5	GO:0005769	1/170	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG80P6P5	GO:0008593	1/170	regulation of Notch signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG80P6P5	GO:0044130	1/170	negative regulation of growth of symbiont in host	biological_process	"Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
EOG80P6P5	GO:0008021	1/170	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG80P6P5	GO:0005802	1/170	trans-Golgi network	cellular_component	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]
EOG80P6P5	GO:0055037	1/170	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG80P6P5	GO:0006897	1/170	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG80P6P5	GO:0048102	1/170	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG80P6P5	GO:0043025	1/170	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG80P6P5	GO:0042147	1/170	retrograde transport, endosome to Golgi	biological_process	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]
EOG80P6P5	GO:0035071	1/170	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG80P6P5	GO:0016197	1/170	endosomal transport	biological_process	"The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]
EOG8MPM3X	GO:0004866	23/98	endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl]
EOG8MPM3X	GO:0005615	23/98	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8MPM3X	GO:0046331	1/98	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8MPM3X	GO:0005515	1/98	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8MPM3X	GO:0005576	1/98	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8MPM3X	GO:0006910	1/98	phagocytosis, recognition	biological_process	"The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149]
EOG8MPM3X	GO:0050832	1/98	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG81ZHSW	GO:0016020	17/90	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8SJ7V8	GO:0005524	40/149	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SJ7V8	GO:0004674	38/149	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8SJ7V8	GO:0004713	2/149	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8SJ7V8	GO:0004672	2/149	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8SJ7V8	GO:0006468	2/149	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8SJ7V8	GO:0004697	1/149	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG8SJ7V8	GO:0007498	1/149	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG82RGNT	GO:0016740	1/73	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG82RGNT	GO:0004597	1/73	peptide-aspartate beta-dioxygenase activity	molecular_function	"Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2." [EC:1.14.11.16]
EOG8QZB0R	GO:0045202	1/108	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8QZB0R	GO:0048841	1/108	regulation of axon extension involved in axon guidance	biological_process	"Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]
EOG8QZB0R	GO:0048786	1/108	presynaptic active zone	cellular_component	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
EOG8QZB0R	GO:0007412	1/108	axon target recognition	biological_process	"The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437]
EOG8QZB0R	GO:0048675	1/108	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG8QZB0R	GO:0005515	1/108	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QZB0R	GO:0005925	1/108	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8QZB0R	GO:0043234	1/108	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8QZB0R	GO:0031290	1/108	retinal ganglion cell axon guidance	biological_process	"The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs]
EOG8QZB0R	GO:0032440	1/108	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8QZB0R	GO:0008594	1/108	photoreceptor cell morphogenesis	biological_process	"The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
EOG8QZB0R	GO:0051124	1/108	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8QZB0R	GO:0007411	1/108	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8QZB0R	GO:0007416	1/108	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG8QZB0R	GO:0045467	1/108	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8QZB0R	GO:0048490	1/108	anterograde synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron, along the cytoskeleton, away from the neuronal cell body." [GOC:jid, GOC:lmg]
EOG8QZB0Q	GO:0003774	14/97	motor activity	molecular_function	"Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
EOG8QZB0Q	GO:0016459	14/97	myosin complex	cellular_component	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
EOG8QZB0Q	GO:0005524	14/97	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QZB0Q	GO:0007165	11/97	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8QZB0Q	GO:0005856	9/97	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG805VH1	GO:0008270	2/30	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG805VH1	GO:0003723	2/30	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8QZB0T	GO:0005249	1/81	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8QZB0T	GO:0071805	1/81	potassium ion transmembrane transport	biological_process	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
EOG8QZB0T	GO:0005887	1/81	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QZB0T	GO:0042391	1/81	regulation of membrane potential	biological_process	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
EOG8XKXPH	GO:0016020	142/797	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XKXPH	GO:0005515	4/797	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8XKXPH	GO:0015031	1/797	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8XKXPH	GO:0046331	1/797	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8XKXPH	GO:0005789	1/797	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8XKXPH	GO:0016021	1/797	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C5G0J	GO:0016787	1/71	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8C5G0J	GO:0006497	1/71	protein lipidation	biological_process	"The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]
EOG8C5G0J	GO:0030018	1/71	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8C5G0J	GO:0046331	1/71	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG88KTR8	GO:0005524	48/122	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88KTR8	GO:0015991	47/122	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG88KTR8	GO:0046961	45/122	proton-transporting ATPase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]
EOG88KTR8	GO:0033180	43/122	proton-transporting V-type ATPase, V1 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG88KTR8	GO:0046034	3/122	ATP metabolic process	biological_process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]
EOG88KTR8	GO:0000221	2/122	vacuolar proton-transporting V-type ATPase, V1 domain	cellular_component	"The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG88KTR8	GO:0016787	2/122	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG88KTR8	GO:0033178	2/122	proton-transporting two-sector ATPase complex, catalytic domain	cellular_component	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056]
EOG88KTR8	GO:0016820	2/122	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	molecular_function	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]
EOG88KTR8	GO:0005886	2/122	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG88KTR8	GO:0071456	1/122	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG88KTR8	GO:0033181	1/122	plasma membrane proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
EOG88KTR8	GO:0015992	1/122	proton transport	biological_process	"The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
EOG88KTR8	GO:0008593	1/122	regulation of Notch signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG88KTR8	GO:0007446	1/122	imaginal disc growth	biological_process	"The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387]
EOG88KTR8	GO:0007035	1/122	vacuolar acidification	biological_process	"Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid]
EOG88KTR8	GO:0016197	1/122	endosomal transport	biological_process	"The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]
EOG88KTR8	GO:0048388	1/122	endosomal lumen acidification	biological_process	"Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jid]
EOG8XH2DD	GO:0046856	11/100	phosphatidylinositol dephosphorylation	biological_process	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]
EOG8XH2DD	GO:0052658	2/100	inositol-1,4,5-trisphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate." [EC:3.1.3.56, RHEA:19800]
EOG8XH2DD	GO:0052659	2/100	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56, RHEA:11395]
EOG8XH2DD	GO:0004445	2/100	inositol-polyphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56]
EOG8XH2DD	GO:0046855	1/100	inositol phosphate dephosphorylation	biological_process	"The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]
EOG8XH2DD	GO:0016311	1/100	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG8XH2DD	GO:0046030	1/100	inositol trisphosphate phosphatase activity	molecular_function	"Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate." [GOC:bf]
EOG8T4GBJ	GO:0000166	14/72	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8T4GBJ	GO:0003676	14/72	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XH2DF	GO:0016874	2/74	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8XH2DF	GO:0046872	1/74	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XH2DF	GO:0006310	1/74	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8XH2DF	GO:0003677	1/74	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XH2DF	GO:0015074	1/74	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG88KTR0	GO:0051056	12/102	regulation of small GTPase mediated signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
EOG88KTR0	GO:0005096	12/102	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG88KTR5	GO:0006208	28/104	pyrimidine nucleobase catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [CHEBI:26432, GOC:go_curators]
EOG88KTR5	GO:0005737	28/104	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG88KTR5	GO:0016812	25/104	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]
EOG88KTR5	GO:0016810	6/104	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
EOG88KTR5	GO:0004157	5/104	dihydropyrimidinase activity	molecular_function	"Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate." [EC:3.5.2.2]
EOG88KTR5	GO:0045747	1/104	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG88KTR5	GO:0007265	1/104	Ras protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf]
EOG88KTR5	GO:0006207	1/104	'de novo' pyrimidine nucleobase biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]
EOG88KTR5	GO:0007613	1/104	memory	biological_process	"The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089]
EOG88KTR5	GO:0017153	1/104	sodium:dicarboxylate symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]
EOG88KTR5	GO:0016020	1/104	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG88KTR5	GO:0051642	1/104	centrosome localization	biological_process	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
EOG8XH2DM	GO:0005634	13/65	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XH2DM	GO:0003700	13/65	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8XH2DM	GO:0043565	10/65	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8XH2DM	GO:0000976	3/65	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8XH2DM	GO:0042981	1/65	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8XH2DR	GO:0004871	37/127	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8XH2DR	GO:0005525	37/127	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8XH2DR	GO:0003924	37/127	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8XH2DR	GO:0007186	35/127	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8XH2DR	GO:0001664	2/127	G-protein coupled receptor binding	molecular_function	"Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph]
EOG8XH2DR	GO:0031234	2/127	extrinsic component of cytoplasmic side of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah]
EOG8XH2DR	GO:0060158	2/127	phospholipase C-activating dopamine receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:signaling, GOC:tb, PMID:12675914]
EOG8XH2DR	GO:0007188	2/127	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194]
EOG8XH2DR	GO:0005834	2/127	heterotrimeric G-protein complex	cellular_component	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684]
EOG8XH2DR	GO:0031683	2/127	G-protein beta/gamma-subunit complex binding	molecular_function	"Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]
EOG8XH2DR	GO:0007601	1/127	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8XH2DR	GO:0002385	1/127	mucosal immune response	biological_process	"An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
EOG8XH2DR	GO:0007629	1/127	flight behavior	biological_process	"The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
EOG8XH2DR	GO:0007608	1/127	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8XH2DR	GO:0016199	1/127	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG8XH2DR	GO:0016027	1/127	inaD signaling complex	cellular_component	"A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815]
EOG8XH2DR	GO:0071244	1/127	cellular response to carbon dioxide	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:mah]
EOG8XH2DR	GO:0043052	1/127	thermotaxis	biological_process	"The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
EOG8XH2DR	GO:0046872	1/127	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XH2DR	GO:0016056	1/127	rhodopsin mediated signaling pathway	biological_process	"The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response." [GOC:bf, GOC:dph, GOC:hb, GOC:signaling, GOC:tb]
EOG8XH2DR	GO:0006897	1/127	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8XH2DR	GO:0046673	1/127	negative regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG8XH2DR	GO:0030322	1/127	stabilization of membrane potential	biological_process	"The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732]
EOG8XH2DR	GO:0007202	1/127	activation of phospholipase C activity	biological_process	"The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098]
EOG8XH2DR	GO:0016060	1/127	metarhodopsin inactivation	biological_process	"The process in which metarhodopsin is prevented from generating molecular signals. Activated rhodopsin (R*) is inactivated by a two-step process: first, R* is phosphorylated by rhodopsin kinase which lowers the activity of R*. Second, the protein arrestin binds to phosphorylated R* to de-activate it." [GOC:hb, Wikipedia:Visual_phototransduction]
EOG8XH2DR	GO:0016028	1/127	rhabdomere	cellular_component	"The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774]
EOG8XH2DR	GO:0005886	1/127	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8XH2DR	GO:0007602	1/127	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG8PRW54	GO:0003995	85/195	acyl-CoA dehydrogenase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]
EOG8PRW54	GO:0050660	84/195	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8PRW54	GO:0005777	82/195	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8PRW54	GO:0003997	82/195	acyl-CoA oxidase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6]
EOG8PRW54	GO:0006635	81/195	fatty acid beta-oxidation	biological_process	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]
EOG8PRW54	GO:0006629	1/195	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8PRW54	GO:0019395	1/195	fatty acid oxidation	biological_process	"The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732, MetaCyc:FAO-PWY]
EOG8PRW54	GO:0006693	1/195	prostaglandin metabolic process	biological_process	"The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732]
EOG8PRW54	GO:0033540	1/195	fatty acid beta-oxidation using acyl-CoA oxidase	biological_process	"A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5136]
EOG8PRW54	GO:0006091	1/195	generation of precursor metabolites and energy	biological_process	"The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]
EOG8PRW55	GO:0003676	6/83	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QRKJN	GO:0046872	24/79	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QRKJN	GO:0003676	23/79	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QRKJN	GO:0001205	1/79	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG8QRKJN	GO:0007455	1/79	eye-antennal disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8QRKJN	GO:0045944	1/79	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8QRKJN	GO:0008354	1/79	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8QRKJN	GO:0007494	1/79	midgut development	biological_process	"The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
EOG8QRKJN	GO:0005634	1/79	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8QRKJN	GO:0007366	1/79	periodic partitioning by pair rule gene	biological_process	"Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG8QRKJN	GO:0000980	1/79	RNA polymerase II distal enhancer sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH]
EOG8QRKJN	GO:0008101	1/79	decapentaplegic signaling pathway	biological_process	"A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:sart, PMID:17428827]
EOG8QRKJN	GO:0003700	1/79	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8PVRCP	GO:0003676	30/107	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8PVRCP	GO:0008270	13/107	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PVRCP	GO:0005634	13/107	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PVRCP	GO:0006351	11/107	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8PVRCP	GO:0003700	11/107	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8PVRCP	GO:0006366	1/107	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8PVRCP	GO:0006357	1/107	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8PVRCP	GO:0046872	1/107	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8PVRCP	GO:0048813	1/107	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8PVRCP	GO:0000981	1/107	RNA polymerase II transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
EOG8JDKND	GO:0030414	2/95	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8JDKND	GO:0005576	2/95	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8JDKND	GO:0005887	1/95	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JDKND	GO:0004872	1/95	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8JDKND	GO:0002168	1/95	instar larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8JDKND	GO:0016324	1/95	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8JDKND	GO:0007411	1/95	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8DZ484	GO:0003676	1/92	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DZ484	GO:0046872	1/92	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8577MX	GO:0016021	75/289	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8577MX	GO:0006486	74/289	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8577MX	GO:0005794	73/289	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8577MX	GO:0046872	72/289	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8577MX	GO:0016757	70/289	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8577MX	GO:0004653	9/289	polypeptide N-acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595]
EOG8577MX	GO:0000139	3/289	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8577MX	GO:0005795	2/289	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG8577MX	GO:0009312	2/289	oligosaccharide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]
EOG8577MX	GO:0006493	1/289	protein O-linked glycosylation	biological_process	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]
EOG8577MX	GO:0033628	1/289	regulation of cell adhesion mediated by integrin	biological_process	"Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add]
EOG8577MX	GO:0070278	1/289	extracellular matrix constituent secretion	biological_process	"The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah]
EOG8577MX	GO:0031589	1/289	cell-substrate adhesion	biological_process	"The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf]
EOG8577MX	GO:0032504	1/289	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8577MX	GO:0008376	1/289	acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]
EOG8577MX	GO:0016266	1/289	O-glycan processing	biological_process	"The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure." [GOC:mah, GOC:pr, PMID:10580130]
EOG8QRKJ1	GO:0005524	42/90	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QRKJ1	GO:0004674	36/90	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8QRKJ1	GO:0004672	4/90	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8QRKJ1	GO:0006468	2/90	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8QRKJ1	GO:0004702	2/90	receptor signaling protein serine/threonine kinase activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah]
EOG8QRKJ1	GO:0023014	2/90	signal transduction by protein phosphorylation	biological_process	"A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling]
EOG8QRKJ1	GO:0030165	1/90	PDZ domain binding	molecular_function	"Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]
EOG8QRKJ1	GO:0004697	1/90	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG8QRKJ1	GO:0030177	1/90	positive regulation of Wnt signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8QRKJ1	GO:0030496	1/90	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG8QRKJ1	GO:0004709	1/90	MAP kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
EOG8QRKJ1	GO:0005813	1/90	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8QRKJ1	GO:0031647	1/90	regulation of protein stability	biological_process	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]
EOG8QRKJ1	GO:0048812	1/90	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8QRKJ1	GO:0007088	1/90	regulation of mitotic nuclear division	biological_process	"Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
EOG8QRKJ1	GO:0005737	1/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8577MP	GO:0006511	26/94	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8577MP	GO:0008234	18/94	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8577MP	GO:0008233	3/94	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8577MP	GO:0016579	1/94	protein deubiquitination	biological_process	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]
EOG8577MP	GO:0004221	1/94	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG8PRW5N	GO:0031409	6/79	pigment binding	molecular_function	"Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah]
EOG8PRW5N	GO:0005576	5/79	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8PRW5N	GO:0005215	2/79	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8PRW5N	GO:0008289	2/79	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG8PRW5N	GO:0036094	1/79	small molecule binding	molecular_function	"Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]
EOG8PRW5N	GO:0018149	1/79	peptide cross-linking	biological_process	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]
EOG8PRW5N	GO:0005737	1/79	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8PCD6Z	GO:0004298	40/103	threonine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8PCD6Z	GO:0019773	37/103	proteasome core complex, alpha-subunit complex	cellular_component	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]
EOG8PCD6Z	GO:0005634	37/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PCD6Z	GO:0006511	36/103	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8PCD6Z	GO:0005737	35/103	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8PCD6Z	GO:0005839	3/103	proteasome core complex	cellular_component	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]
EOG8PCD6Z	GO:0051603	3/103	proteolysis involved in cellular protein catabolic process	biological_process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]
EOG8PCD6Z	GO:0050829	1/103	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8PCD6Z	GO:0001673	1/103	male germ cell nucleus	cellular_component	"The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu]
EOG8PCD6Z	GO:0005875	1/103	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8PCD6Z	GO:0045824	1/103	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG8PCD6Z	GO:0007291	1/103	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8PCD6Z	GO:0006974	1/103	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8PCD6Z	GO:0007370	1/103	ventral furrow formation	biological_process	"Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238]
EOG8PCD6Z	GO:0000502	1/103	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG8PCD6Z	GO:0007290	1/103	spermatid nucleus elongation	biological_process	"The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation." [GOC:bf, GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]
EOG8PCD6Z	GO:0043161	1/103	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG8PCD6Z	GO:0005829	1/103	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8577MJ	GO:0008234	36/141	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8577MJ	GO:0008233	3/141	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8577MJ	GO:0021952	2/141	central nervous system projection neuron axonogenesis	biological_process	"Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8577MJ	GO:0016929	2/141	SUMO-specific protease activity	molecular_function	"Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250]
EOG8577MJ	GO:0060997	2/141	dendritic spine morphogenesis	biological_process	"The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
EOG8577MJ	GO:0005634	2/141	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8577MJ	GO:0016926	2/141	protein desumoylation	biological_process	"The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250]
EOG8577MJ	GO:0003676	1/141	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8577MJ	GO:0008270	1/141	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8577MJ	GO:0007476	1/141	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8577MJ	GO:0060548	1/141	negative regulation of cell death	biological_process	"Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]
EOG8577MJ	GO:0005737	1/141	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8577MJ	GO:0045134	1/141	uridine-diphosphatase activity	molecular_function	"Catalysis of the reaction: UDP + H2O = UMP + phosphate." [EC:3.6.1.6]
EOG8577MJ	GO:0007411	1/141	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8PCD6F	GO:0004553	2/12	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8PCD6F	GO:0005975	2/12	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8XD64V	GO:0005216	20/141	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8XD64V	GO:0016021	20/141	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XD64V	GO:0046873	1/141	metal ion transmembrane transporter activity	molecular_function	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]
EOG8XD64V	GO:0070838	1/141	divalent metal ion transport	biological_process	"The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8XD64V	GO:0016049	1/141	cell growth	biological_process	"The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]
EOG8XD64V	GO:0016787	1/141	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8XD64V	GO:0010960	1/141	magnesium ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." [GOC:dph, GOC:tb]
EOG8XD64V	GO:0055069	1/141	zinc ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
EOG8XD64V	GO:0007005	1/141	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8XD64V	GO:0005261	1/141	cation channel activity	molecular_function	"Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8XD64V	GO:0034703	1/141	cation channel complex	cellular_component	"An ion channel complex through which cations pass." [GOC:mah]
EOG8XH2D7	GO:0005262	6/44	calcium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8XH2D7	GO:0016021	5/44	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XH2D7	GO:0042302	1/44	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8XH2D7	GO:0016020	1/44	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG834ZQ6	GO:0004252	2/6	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG805VHF	GO:0005737	21/66	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG805VHF	GO:0007616	1/66	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG805VHF	GO:0008344	1/66	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG805VHF	GO:0007614	1/66	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG805VHF	GO:0005515	1/66	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG805VHF	GO:0008057	1/66	eye pigment granule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295]
EOG805VHF	GO:0051968	1/66	positive regulation of synaptic transmission, glutamatergic	biological_process	"Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
EOG805VHF	GO:0008021	1/66	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG805VHF	GO:0031083	1/66	BLOC-1 complex	cellular_component	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]
EOG805VHF	GO:0048167	1/66	regulation of synaptic plasticity	biological_process	"A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290]
EOG805VHF	GO:0045963	1/66	negative regulation of dopamine metabolic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]
EOG805VHF	GO:0048047	1/66	mating behavior, sex discrimination	biological_process	"The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700]
EOG8C5G07	GO:0004252	2199/5565	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8C5G07	GO:0006508	98/5565	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8C5G07	GO:0005615	18/5565	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8C5G07	GO:0005576	17/5565	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8C5G07	GO:0007586	11/5565	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG8C5G07	GO:0004175	8/5565	endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8C5G07	GO:0016021	6/5565	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C5G07	GO:0016787	5/5565	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8C5G07	GO:0016301	5/5565	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8C5G07	GO:0008236	5/5565	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8C5G07	GO:0045087	4/5565	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8C5G07	GO:0006629	4/5565	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8C5G07	GO:0006952	3/5565	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8C5G07	GO:0045752	3/5565	positive regulation of Toll signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8C5G07	GO:0050830	3/5565	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG8C5G07	GO:0008063	3/5565	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8C5G07	GO:0008233	3/5565	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8C5G07	GO:0005829	3/5565	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8C5G07	GO:0008889	3/5565	glycerophosphodiester phosphodiesterase activity	molecular_function	"Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]
EOG8C5G07	GO:0006071	3/5565	glycerol metabolic process	biological_process	"The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]
EOG8C5G07	GO:0050832	3/5565	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8C5G07	GO:0022008	2/5565	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8C5G07	GO:0050829	2/5565	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8C5G07	GO:0009950	2/5565	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8C5G07	GO:0035006	2/5565	melanization defense response	biological_process	"The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809]
EOG8C5G07	GO:0007311	2/5565	maternal specification of dorsal/ventral axis, oocyte, germ-line encoded	biological_process	"Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8C5G07	GO:0031638	2/5565	zymogen activation	biological_process	"The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd]
EOG8C5G07	GO:0008270	1/5565	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8C5G07	GO:0006964	1/5565	positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
EOG8C5G07	GO:0005515	1/5565	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8C5G07	GO:0005622	1/5565	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8C5G07	GO:0004435	1/5565	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8C5G07	GO:0048812	1/5565	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8C5G07	GO:0008592	1/5565	regulation of Toll signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8C5G07	GO:0006967	1/5565	positive regulation of antifungal peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah]
EOG8C5G07	GO:0003964	1/5565	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8C5G07	GO:0035008	1/5565	positive regulation of melanization defense response	biological_process	"Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf]
EOG8C5G07	GO:0035007	1/5565	regulation of melanization defense response	biological_process	"Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf]
EOG8C5G07	GO:0035556	1/5565	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8C5G07	GO:0003723	1/5565	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8C5G07	GO:0005581	1/5565	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8C5G07	GO:0004930	1/5565	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8C5G07	GO:0006909	1/5565	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8C5G07	GO:0004180	1/5565	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8C5G07	GO:0006959	1/5565	humoral immune response	biological_process	"An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]
EOG8C5G07	GO:0004471	1/5565	malate dehydrogenase (decarboxylating) (NAD+) activity	molecular_function	"Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39]
EOG8C5G07	GO:0016485	1/5565	protein processing	biological_process	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]
EOG8C5G07	GO:0003677	1/5565	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8C5G07	GO:0051287	1/5565	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8C5G07	GO:0042060	1/5565	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG81ZHS4	GO:0005524	23/145	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG81ZHS4	GO:0005829	21/145	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG81ZHS4	GO:0046872	21/145	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81ZHS4	GO:0004792	21/145	thiosulfate sulfurtransferase activity	molecular_function	"Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate." [EC:2.8.1.1, RHEA:16884]
EOG81ZHS4	GO:0002143	21/145	tRNA wobble position uridine thiolation	biological_process	"The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:16871210]
EOG81ZHS4	GO:0016787	20/145	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG81ZHS4	GO:0006777	19/145	Mo-molybdopterin cofactor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473]
EOG81ZHS4	GO:0018192	19/145	enzyme active site formation via cysteine modification to L-cysteine persulfide	biological_process	"The formation of an enzyme active site via modification of peptidyl-cysteine to peptidyl-L-cysteine persulfide." [PMID:11592406, RESID:AA0269]
EOG81ZHS4	GO:0061604	14/145	molybdopterin-synthase sulfurtransferase activity	molecular_function	"Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine <=> AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase." [EC:2.8.1.11, GOC:dph, PMID:18154309, PMID:22370186]
EOG81ZHS4	GO:0061605	14/145	molybdopterin-synthase adenylyltransferase activity	molecular_function	"Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP." [EC:2.7.7.80, GOC:dph, PMID:18154309, PMID:22370186]
EOG81ZHS4	GO:0016779	5/145	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG81ZHS4	GO:0003824	2/145	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG81ZHS4	GO:0016740	2/145	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG81ZHS4	GO:0004842	1/145	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG81ZHS4	GO:0032324	1/145	molybdopterin cofactor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah]
EOG81ZHS4	GO:0016575	1/145	histone deacetylation	biological_process	"The modification of histones by removal of acetyl groups." [GOC:ai]
EOG81ZHS4	GO:0004407	1/145	histone deacetylase activity	molecular_function	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.98, PMID:9893272]
EOG81ZHS4	GO:0005680	1/145	anaphase-promoting complex	cellular_component	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]
EOG805VHB	GO:0015074	4/18	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG805VHB	GO:0003676	3/18	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG805VHB	GO:0004190	2/18	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG805VHB	GO:0003723	1/18	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG805VHB	GO:0003964	1/18	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8C5G03	GO:0003779	2/344	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8C5G03	GO:0006936	1/344	muscle contraction	biological_process	"A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]
EOG8C5G03	GO:0051015	1/344	actin filament binding	molecular_function	"Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]
EOG8C5G03	GO:0048477	1/344	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8C5G03	GO:0007507	1/344	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8C5G03	GO:0030017	1/344	sarcomere	cellular_component	"The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]
EOG8C5G03	GO:0010591	1/344	regulation of lamellipodium assembly	biological_process	"Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG8C5G03	GO:0070865	1/344	investment cone	cellular_component	"A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization." [GOC:sart, PMID:15829565, PMID:9550716]
EOG8C5G03	GO:0045451	1/344	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8C5G03	GO:0007315	1/344	pole plasm assembly	biological_process	"Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8C5G03	GO:0048813	1/344	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG805VHT	GO:0005634	5/39	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG805VHT	GO:0000245	5/39	spliceosomal complex assembly	biological_process	"The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]
EOG8S4RZ0	GO:0016021	116/397	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S4RZ0	GO:0005215	113/397	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8S4RZ0	GO:0055085	6/397	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8S4RZ0	GO:0015267	5/397	channel activity	molecular_function	"Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-]
EOG8S4RZ0	GO:0003014	3/397	renal system process	biological_process	"A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10]
EOG8S4RZ0	GO:0016020	3/397	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8S4RZ0	GO:0015250	1/397	water channel activity	molecular_function	"Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729]
EOG8S4RZ0	GO:0046662	1/397	regulation of oviposition	biological_process	"Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:ai]
EOG8S4RZ0	GO:0006833	1/397	water transport	biological_process	"The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8S4RZ0	GO:0030104	1/397	water homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of water within an organism or cell." [GOC:dph, GOC:mah, GOC:tb]
EOG81K1SQ	GO:0030170	74/266	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG81K1SQ	GO:0019752	72/266	carboxylic acid metabolic process	biological_process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]
EOG81K1SQ	GO:0016831	67/266	carboxy-lyase activity	molecular_function	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]
EOG81K1SQ	GO:0004782	5/266	sulfinoalanine decarboxylase activity	molecular_function	"Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2." [EC:4.1.1.29]
EOG81K1SQ	GO:0004351	2/266	glutamate decarboxylase activity	molecular_function	"Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2." [EC:4.1.1.15]
EOG81K1SQ	GO:0008345	1/266	larval locomotory behavior	biological_process	"Locomotory behavior in a larval (immature) organism." [GOC:ai]
EOG81K1SQ	GO:0007528	1/266	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG81K1SQ	GO:0004068	1/266	aspartate 1-decarboxylase activity	molecular_function	"Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11]
EOG81K1SQ	GO:0008355	1/266	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG81K1SQ	GO:0019483	1/266	beta-alanine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732]
EOG81K1SQ	GO:0007632	1/266	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG81K1SQ	GO:0009612	1/266	response to mechanical stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]
EOG81K1SQ	GO:0006212	1/266	uracil catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators]
EOG81K1SQ	GO:0045213	1/266	neurotransmitter receptor metabolic process	biological_process	"The chemical reactions and pathways involving neurotransmitter receptors." [GOC:go_curators]
EOG81K1SQ	GO:0007416	1/266	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG81K1SQ	GO:0042136	1/266	neurotransmitter biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [CHEBI:25512, GOC:jl]
EOG81K1SQ	GO:0048066	1/266	developmental pigmentation	biological_process	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
EOG81K1SQ	GO:0009449	1/266	gamma-aminobutyric acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai]
EOG81K1SQ	GO:0006538	1/266	glutamate catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
EOG8QVFS8	GO:0008081	29/133	phosphoric diester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]
EOG8QVFS8	GO:0006629	28/133	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8QVFS8	GO:0006650	1/133	glycerophospholipid metabolic process	biological_process	"The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]
EOG8QVFS8	GO:0047396	1/133	glycosylphosphatidylinositol diacylglycerol-lyase activity	molecular_function	"Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate." [EC:4.6.1.14, MetaCyc:3.1.4.47-RXN]
EOG85XBD5	GO:0005509	62/282	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG85XBD5	GO:0048190	1/282	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG85XBD5	GO:0048812	1/282	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8QNQCP	GO:0016791	1/6	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG8QNQCP	GO:0004035	1/6	alkaline phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1]
EOG8B2WC0	GO:0000242	1/85	pericentriolar material	cellular_component	"A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]
EOG8B2WC0	GO:0007099	1/85	centriole replication	biological_process	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194]
EOG8B2WC5	GO:0016301	3/89	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8B2WC5	GO:0006915	2/89	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8B2WC5	GO:0051124	1/89	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8B2WC5	GO:0031932	1/89	TORC2 complex	cellular_component	"A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787]
EOG8B2WC5	GO:0048813	1/89	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8B2WC5	GO:0005829	1/89	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8B2WC5	GO:0003676	1/89	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8B2WC5	GO:0001932	1/89	regulation of protein phosphorylation	biological_process	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]
EOG8B2WC8	GO:0048149	1/85	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8B2WC8	GO:0045887	1/85	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8B2WC8	GO:0034452	1/85	dynactin binding	molecular_function	"Interacting selectively and non-covalently with any part of a dynactin complex; dynactin is a large protein complex that activates dynein-based motor activity." [GOC:BHF, GOC:mah]
EOG8B2WC8	GO:0005802	1/85	trans-Golgi network	cellular_component	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]
EOG87M4CW	GO:0008270	37/166	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87M4CW	GO:0016491	33/166	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG87M4CW	GO:0003960	3/166	NADPH:quinone reductase activity	molecular_function	"Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5]
EOG87M4CW	GO:0047522	1/166	15-oxoprostaglandin 13-oxidase activity	molecular_function	"Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, KEGG:R04556, KEGG:R04557, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN]
EOG87M4CW	GO:0036132	1/166	13-prostaglandin reductase activity	molecular_function	"Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin." [EC:1.3.1.48, GOC:mw, KEGG:R04556, KEGG:R04557, PMID:17449869]
EOG88SK77	GO:0005524	25/88	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88SK77	GO:0017111	24/88	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG88SK76	GO:0005524	1/8	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88SK76	GO:0004812	1/8	aminoacyl-tRNA ligase activity	molecular_function	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
EOG88SK76	GO:0016788	1/8	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG88SK76	GO:0019478	1/8	D-amino acid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg]
EOG88SK76	GO:0006418	1/8	tRNA aminoacylation for protein translation	biological_process	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]
EOG88SK76	GO:0005737	1/8	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG88SK71	GO:0005249	24/134	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG88SK71	GO:0016021	22/134	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88SK71	GO:0000155	20/134	phosphorelay sensor kinase activity	molecular_function	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
EOG88SK71	GO:0003676	1/134	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88SK71	GO:0004871	1/134	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG88SK71	GO:0006813	1/134	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG88SK71	GO:0042391	1/134	regulation of membrane potential	biological_process	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
EOG88SK71	GO:0016020	1/134	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG88SK71	GO:0008076	1/134	voltage-gated potassium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
EOG88SK71	GO:0071805	1/134	potassium ion transmembrane transport	biological_process	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
EOG8616JB	GO:0022857	20/63	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8616JB	GO:0016021	20/63	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88SK72	GO:0004012	26/97	phospholipid-translocating ATPase activity	molecular_function	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684]
EOG88SK72	GO:0005524	26/97	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88SK72	GO:0016021	26/97	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88SK72	GO:0000287	26/97	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG88SK72	GO:0019829	25/97	cation-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]
EOG88SK79	GO:0005524	27/87	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88SK79	GO:0015991	26/87	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG88SK79	GO:0016820	26/87	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	molecular_function	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]
EOG88SK79	GO:0046034	25/87	ATP metabolic process	biological_process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]
EOG88SK79	GO:0033180	23/87	proton-transporting V-type ATPase, V1 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG88SK79	GO:0033178	2/87	proton-transporting two-sector ATPase complex, catalytic domain	cellular_component	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056]
EOG88SK79	GO:0007035	1/87	vacuolar acidification	biological_process	"Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid]
EOG88SK79	GO:0048471	1/87	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG88SK79	GO:0005903	1/87	brush border	cellular_component	"Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194]
EOG88SK79	GO:0033181	1/87	plasma membrane proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
EOG88SK79	GO:0000221	1/87	vacuolar proton-transporting V-type ATPase, V1 domain	cellular_component	"The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG88SK79	GO:0005886	1/87	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG88SK79	GO:0005769	1/87	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG8616JJ	GO:0007076	3/75	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8616JJ	GO:0000796	3/75	condensin complex	cellular_component	"A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
EOG8616JJ	GO:0005874	1/75	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8616JJ	GO:0000226	1/75	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG87M4CG	GO:0003677	44/95	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG87M4CG	GO:0006072	10/95	glycerol-3-phosphate metabolic process	biological_process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]
EOG87M4CG	GO:0004367	10/95	glycerol-3-phosphate dehydrogenase [NAD+] activity	molecular_function	"Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+." [EC:1.1.1.8, EC:1.1.1.94]
EOG87M4CG	GO:0009331	10/95	glycerol-3-phosphate dehydrogenase complex	cellular_component	"An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3]
EOG87M4CG	GO:0003676	6/95	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG87M4CG	GO:0005515	1/95	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG87M4CG	GO:0005634	1/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87M4CG	GO:0005701	1/95	polytene chromosome chromocenter	cellular_component	"A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012]
EOG87M4CG	GO:0090053	1/95	positive regulation of chromatin silencing at centromere	biological_process	"Any process that increases the frequency, rate or extent of chromatin silencing at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:dph, GOC:tb]
EOG87M4CG	GO:0003682	1/95	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG87M4CG	GO:0008270	1/95	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87M4CG	GO:0009048	1/95	dosage compensation by inactivation of X chromosome	biological_process	"Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex." [GOC:jl, GOC:pr, ISBN:0140512888, PMID:11498577]
EOG87M4CG	GO:0035556	1/95	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG87M4CG	GO:0000792	1/95	heterochromatin	cellular_component	"A compact and highly condensed form of chromatin." [GOC:elh]
EOG87M4CG	GO:0005721	1/95	pericentric heterochromatin	cellular_component	"Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [PMID:12019236, PMID:20206496, PMID:22729156]
EOG87M4CG	GO:0046872	1/95	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG87M4CG	GO:0000775	1/95	chromosome, centromeric region	cellular_component	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
EOG8616JV	GO:0007298	1/93	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8616JV	GO:0045171	1/93	intercellular bridge	cellular_component	"A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised." [PMID:9635420]
EOG8616JV	GO:0000445	1/93	THO complex part of transcription export complex	cellular_component	"The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]
EOG8616JV	GO:0050839	1/93	cell adhesion molecule binding	molecular_function	"Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai]
EOG8616JV	GO:0006397	1/93	mRNA processing	biological_process	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]
EOG8616JV	GO:0001745	1/93	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8616JV	GO:0046331	1/93	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8616JV	GO:0048260	1/93	positive regulation of receptor-mediated endocytosis	biological_process	"Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb]
EOG8616JV	GO:0009415	1/93	response to water	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl]
EOG8616JV	GO:0006950	1/93	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8616JV	GO:0032154	1/93	cleavage furrow	cellular_component	"In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409]
EOG8616JV	GO:0048749	1/93	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8616JV	GO:0007015	1/93	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8616JV	GO:0017124	1/93	SH3 domain binding	molecular_function	"Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]
EOG8616JV	GO:0043063	1/93	intercellular bridge organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another." [GOC:jid]
EOG8616JV	GO:0030496	1/93	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG87M4CB	GO:0005737	21/83	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87M4CB	GO:0006434	21/83	seryl-tRNA aminoacylation	biological_process	"The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG87M4CB	GO:0005524	21/83	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87M4CB	GO:0004828	21/83	serine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11]
EOG87M4CB	GO:0005634	3/83	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87M4CB	GO:0008270	3/83	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87M4CB	GO:0003676	2/83	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG87M4CB	GO:0000049	1/83	tRNA binding	molecular_function	"Interacting selectively and non-covalently with transfer RNA." [GOC:ai]
EOG87M4CB	GO:0070584	1/83	mitochondrion morphogenesis	biological_process	"The process in which the anatomical structures of a mitochondrion are generated and organized." [GOC:mah]
EOG87M4CB	GO:0005739	1/83	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG87M4CB	GO:0000166	1/83	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG87M4CB	GO:0045333	1/83	cellular respiration	biological_process	"The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732]
EOG87M4CB	GO:0016874	1/83	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG83N9WQ	GO:0008270	26/90	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83N9WQ	GO:0004842	1/90	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG83N9WQ	GO:0016567	1/90	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG83N9WQ	GO:0016874	1/90	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8MPM4C	GO:0080019	109/262	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8MPM4C	GO:0005737	1/262	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8MPM4C	GO:0050062	1/262	long-chain-fatty-acyl-CoA reductase activity	molecular_function	"Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH." [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN]
EOG8MPM4C	GO:0005509	1/262	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8MPM4C	GO:0016042	1/262	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8MPM4C	GO:0035002	1/262	liquid clearance, open tracheal system	biological_process	"The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352]
EOG8MPM4C	GO:0004043	1/262	L-aminoadipate-semialdehyde dehydrogenase activity	molecular_function	"Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31]
EOG8MPM4C	GO:0045177	1/262	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8MPM4C	GO:0035149	1/262	lumen formation, open tracheal system	biological_process	"Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
EOG8MPM4C	GO:0004623	1/262	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG8MPM4C	GO:0055114	1/262	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8MKQZB	GO:0006886	25/85	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8MKQZB	GO:0008565	25/85	protein transporter activity	molecular_function	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
EOG8MKQZB	GO:0016192	24/85	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8MKQZB	GO:0030117	24/85	membrane coat	cellular_component	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]
EOG8MKQZB	GO:0022008	1/85	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8MKQZB	GO:0016183	1/85	synaptic vesicle coating	biological_process	"A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:curators, PMID:10099709]
EOG8MKQZB	GO:0007269	1/85	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8MKQZB	GO:0030135	1/85	coated vesicle	cellular_component	"Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]
EOG8MKQZB	GO:0030122	1/85	AP-2 adaptor complex	cellular_component	"A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499]
EOG8MKQZB	GO:0008021	1/85	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8MKQZB	GO:0006897	1/85	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8MKQZB	GO:0006901	1/85	vesicle coating	biological_process	"A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid]
EOG8XWJC2	GO:0005272	70/161	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8XWJC2	GO:0016021	67/161	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XWJC2	GO:0016020	3/161	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XWJC2	GO:0005886	1/161	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8XWJC2	GO:0009415	1/161	response to water	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl]
EOG8XWJC2	GO:0035002	1/161	liquid clearance, open tracheal system	biological_process	"The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352]
EOG8XWJC2	GO:0071462	1/161	cellular response to water stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:mah]
EOG8XWJC2	GO:0042756	1/161	drinking behavior	biological_process	"The specific behavior of an organism relating to the intake of liquids, especially water." [GOC:curators, GOC:pr]
EOG8MKQZ1	GO:0016021	25/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8MKQZ1	GO:0004930	24/91	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8MKQZ1	GO:0007015	1/91	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8MKQZ1	GO:0006468	1/91	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8MKQZ1	GO:0004674	1/91	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8MKQZ1	GO:0007186	1/91	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8MKQZ1	GO:0008360	1/91	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG88SK7C	GO:0005085	23/53	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG88SK7C	GO:0007264	23/53	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG88SK7C	GO:0005622	23/53	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG88SK7B	GO:0003700	1/188	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG88SK7B	GO:0016832	1/188	aldehyde-lyase activity	molecular_function	"Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [http://www.mercksource.com/]
EOG88SK7B	GO:0005887	1/188	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88SK7B	GO:0005840	1/188	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG88SK7B	GO:0008270	1/188	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG88SK7B	GO:0005634	1/188	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88SK7B	GO:0005975	1/188	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG88SK7H	GO:0006749	99/277	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG88SK7H	GO:0003840	99/277	gamma-glutamyltransferase activity	molecular_function	"Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2]
EOG88SK7H	GO:0003810	1/277	protein-glutamine gamma-glutamyltransferase activity	molecular_function	"Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124]
EOG88SK7H	GO:0032504	1/277	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG88SK7H	GO:0048812	1/277	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG88SK7H	GO:0005615	1/277	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8616J9	GO:0003677	11/71	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8616J9	GO:0004518	10/71	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8616J9	GO:0004527	1/71	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG88SK7J	GO:0003887	3/7	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG88SK7J	GO:0003677	3/7	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8B2WCD	GO:0007094	24/89	mitotic spindle assembly checkpoint	biological_process	"A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190]
EOG8B2WCD	GO:0051315	1/89	attachment of mitotic spindle microtubules to kinetochore	biological_process	"The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during mitosis. During mitosis, the kinetochores of sister chromosomes are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb]
EOG8B2WCD	GO:0000776	1/89	kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG8B2WCD	GO:0005654	1/89	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG8B2WCD	GO:0005635	1/89	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG83JFJJ	GO:0035556	82/275	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG83JFJJ	GO:0016021	78/275	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83JFJJ	GO:0000166	76/275	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG83JFJJ	GO:0004016	72/275	adenylate cyclase activity	molecular_function	"Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]
EOG83JFJJ	GO:0009190	12/275	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG83JFJJ	GO:0016849	11/275	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG83JFJJ	GO:0006171	3/275	cAMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]
EOG83JFJJ	GO:0007611	1/275	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG83JFJJ	GO:0007186	1/275	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG83JFJJ	GO:0001582	1/275	detection of chemical stimulus involved in sensory perception of sweet taste	biological_process	"The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
EOG83JFJJ	GO:0046872	1/275	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83JFJJ	GO:0007614	1/275	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG83JFJJ	GO:0007619	1/275	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG83JFJJ	GO:0007617	1/275	mating behavior	biological_process	"The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph]
EOG83JFJJ	GO:0001661	1/275	conditioned taste aversion	biological_process	"A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659]
EOG83JFJJ	GO:0007591	1/275	molting cycle, chitin-based cuticle	biological_process	"The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu]
EOG83JFJJ	GO:0005524	1/275	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG83JFJJ	GO:0007612	1/275	learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544]
EOG83JFJJ	GO:0007268	1/275	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG83JFJJ	GO:0004383	1/275	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG83JFJJ	GO:0008306	1/275	associative learning	biological_process	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
EOG83JFJJ	GO:0042302	1/275	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG83JFJJ	GO:0009744	1/275	response to sucrose	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl]
EOG83JFJJ	GO:0008340	1/275	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG83JFJJ	GO:0016020	1/275	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG83JFJJ	GO:0010353	1/275	response to trehalose	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512]
EOG83JFJJ	GO:0048149	1/275	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG83JFJJ	GO:0008294	1/275	calcium- and calmodulin-responsive adenylate cyclase activity	molecular_function	"Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin." [EC:4.6.1.1, GOC:mah]
EOG83JFJJ	GO:0009408	1/275	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG83JFJJ	GO:0007625	1/275	grooming behavior	biological_process	"The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl, GOC:pr]
EOG83JFJJ	GO:0007613	1/275	memory	biological_process	"The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089]
EOG83JFJJ	GO:0003676	1/275	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83JFJJ	GO:0010738	1/275	regulation of protein kinase A signaling	biological_process	"Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]
EOG83JFJJ	GO:0019933	1/275	cAMP-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
EOG83JFJJ	GO:0031000	1/275	response to caffeine	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah]
EOG83JFJJ	GO:0090328	1/275	regulation of olfactory learning	biological_process	"Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb]
EOG83JFJJ	GO:0030431	1/275	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG83JFJJ	GO:0048675	1/275	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG83JFJJ	GO:0004930	1/275	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG83JFJJ	GO:0008355	1/275	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG83JFJJ	GO:0007274	1/275	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG83JFJJ	GO:0007528	1/275	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG83JFJJ	GO:0006979	1/275	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8QVFSR	GO:0003677	27/92	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84F8PZ	GO:0007076	21/82	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG84F8PZ	GO:0000799	4/82	nuclear condensin complex	cellular_component	"A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus." [GOC:elh]
EOG84F8PZ	GO:0005524	1/82	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG84F8PZ	GO:0004342	1/82	glucosamine-6-phosphate deaminase activity	molecular_function	"Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+)." [EC:3.5.99.6, RHEA:12175]
EOG84F8PZ	GO:0004674	1/82	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG84F8PZ	GO:0005975	1/82	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG84F8PZ	GO:0007060	1/82	male meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai]
EOG84F8PZ	GO:0051276	1/82	chromosome organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG84F8PZ	GO:0006044	1/82	N-acetylglucosamine metabolic process	biological_process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
EOG84F8PZ	GO:0005634	1/82	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8QVFSN	GO:0046872	1/8	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QVFSN	GO:0004641	1/8	phosphoribosylformylglycinamidine cyclo-ligase activity	molecular_function	"Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate." [EC:6.3.3.1, RHEA:23035]
EOG8QVFSN	GO:0006189	1/8	'de novo' IMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]
EOG8QVFSN	GO:0005524	1/8	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QVFSN	GO:0005737	1/8	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8QVFSN	GO:0016742	1/8	hydroxymethyl-, formyl- and related transferase activity	molecular_function	"Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2, GOC:mah]
EOG8QVFSN	GO:0009113	1/8	purine nucleobase biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [CHEBI:26386, GOC:go_curators, ISBN:0198506732]
EOG8QVFSN	GO:0004637	1/8	phosphoribosylamine-glycine ligase activity	molecular_function	"Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate." [EC:6.3.4.13, RHEA:17456]
EOG8MD0GT	GO:0007275	1/19	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8MD0GT	GO:0004872	1/19	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8MD0GT	GO:0018149	1/19	peptide cross-linking	biological_process	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]
EOG8MD0GT	GO:0016020	1/19	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8MD0GT	GO:0005737	1/19	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RV56H	GO:0005215	33/156	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8RV56H	GO:0016021	31/156	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RV56H	GO:0016020	3/156	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RV56H	GO:0005886	1/156	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8RV56H	GO:0055085	1/156	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8RV56H	GO:0007399	1/156	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8RV56H	GO:0006812	1/156	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8RV56H	GO:0007398	1/156	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG8RV56H	GO:0016337	1/156	single organismal cell-cell adhesion	biological_process	"The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb]
EOG8RV56H	GO:0007498	1/156	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8RV56H	GO:0015267	1/156	channel activity	molecular_function	"Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-]
EOG8RV56H	GO:0031410	1/156	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG8RV56H	GO:0005912	1/156	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8RV56H	GO:0046331	1/156	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8RV56H	GO:0044719	1/156	regulation of imaginal disc-derived wing size	biological_process	"Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
EOG8RV56H	GO:0030707	1/156	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8RV56H	GO:0007219	1/156	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8RV56H	GO:0005261	1/156	cation channel activity	molecular_function	"Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG80GG71	GO:0003676	20/947	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80GG71	GO:0008270	20/947	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80GG71	GO:0003677	3/947	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80GG71	GO:0005634	3/947	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80GG71	GO:0004190	2/947	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG80GG71	GO:0003964	2/947	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG80GG71	GO:0003723	2/947	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG80GG71	GO:0000786	1/947	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG80GG71	GO:0015074	1/947	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG80GG71	GO:0004812	1/947	aminoacyl-tRNA ligase activity	molecular_function	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
EOG80GG71	GO:0006334	1/947	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8VMHVF	GO:0009116	27/102	nucleoside metabolic process	biological_process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]
EOG8VMHVF	GO:0004731	27/102	purine-nucleoside phosphorylase activity	molecular_function	"Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1]
EOG8FBM7M	GO:0030915	32/108	Smc5-Smc6 complex	cellular_component	"A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739]
EOG8FBM7M	GO:0000724	32/108	double-strand break repair via homologous recombination	biological_process	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]
EOG8FBM7M	GO:0006974	1/108	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG886BS9	GO:0003700	1/119	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG886BS9	GO:0007035	1/119	vacuolar acidification	biological_process	"Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid]
EOG886BS9	GO:0008593	1/119	regulation of Notch signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG886BS9	GO:0016021	1/119	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG886BS9	GO:0043565	1/119	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG886BS9	GO:0005634	1/119	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TTK0Q	GO:0008270	24/79	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TTK0Q	GO:0003677	2/79	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TTK0Q	GO:0005634	2/79	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TTK0Q	GO:0007005	1/79	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8TTK0Q	GO:0006470	1/79	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8TTK0Q	GO:0048565	1/79	digestive tract development	biological_process	"The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators]
EOG8TTK0Q	GO:0005886	1/79	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8TTK0Q	GO:0035335	1/79	peptidyl-tyrosine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
EOG8TTK0Q	GO:0051046	1/79	regulation of secretion	biological_process	"Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
EOG8TTK0Q	GO:0030382	1/79	sperm mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144]
EOG8TTK0Q	GO:0005737	1/79	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8TTK0Q	GO:0004725	1/79	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG82NMDZ	GO:0007367	1/97	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG82NMDZ	GO:0046331	1/97	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG82NMDZ	GO:0048592	1/97	eye morphogenesis	biological_process	"The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu]
EOG82NMDZ	GO:0042067	1/97	establishment of ommatidial planar polarity	biological_process	"The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
EOG82NMDZ	GO:0031648	1/97	protein destabilization	biological_process	"Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah]
EOG82NMDZ	GO:0043065	1/97	positive regulation of apoptotic process	biological_process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG82NMDZ	GO:0042803	1/97	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG82NMDZ	GO:0030162	1/97	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG82NMDZ	GO:0042308	1/97	negative regulation of protein import into nucleus	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl]
EOG82NMDZ	GO:0005634	1/97	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82NMDZ	GO:0045879	1/97	negative regulation of smoothened signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG82NMDZ	GO:0005515	1/97	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG82NMDZ	GO:0016567	1/97	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG82NMDZ	GO:0001654	1/97	eye development	biological_process	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
EOG82NMDZ	GO:0046330	1/97	positive regulation of JNK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8QJV30	GO:0007267	26/96	cell-cell signaling	biological_process	"Any process that mediates the transfer of information from one cell to another." [GOC:mah]
EOG8QJV30	GO:0051642	1/96	centrosome localization	biological_process	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
EOG8QJV30	GO:0051382	1/96	kinetochore assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]
EOG8QJV30	GO:0005634	1/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8QJV30	GO:0000922	1/96	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8QJV30	GO:0007059	1/96	chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
EOG8QJV30	GO:0005654	1/96	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG8QJV30	GO:0008017	1/96	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8QJV30	GO:0005819	1/96	spindle	cellular_component	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
EOG8QJV30	GO:0051726	1/96	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8QJV30	GO:0005886	1/96	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8QJV30	GO:0005737	1/96	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8QJV30	GO:0043148	1/96	mitotic spindle stabilization	biological_process	"The cell cycle process in which spindle integrity is maintained during M phase of mitosis." [GOC:go_curators]
EOG8QJV30	GO:0007346	1/96	regulation of mitotic cell cycle	biological_process	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8QJV30	GO:0007052	1/96	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8QJV30	GO:0005876	1/96	spindle microtubule	cellular_component	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]
EOG8QJV30	GO:0008157	1/96	protein phosphatase 1 binding	molecular_function	"Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl]
EOG8QJV30	GO:0043146	1/96	spindle stabilization	biological_process	"Any process involved in maintaining the structure and integrity of the spindle." [GOC:go_curators]
EOG8QJV35	GO:0050909	1/104	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8QJV35	GO:0005886	1/104	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8QJV35	GO:0016021	1/104	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82NMDN	GO:0008237	25/98	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG82NMDN	GO:0034701	22/98	tripeptidase activity	molecular_function	"Catalysis of the hydrolysis of a tripeptide." [GOC:mah]
EOG82NMDN	GO:0016805	22/98	dipeptidase activity	molecular_function	"Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com]
EOG82NMDN	GO:0009014	2/98	succinyl-diaminopimelate desuccinylase activity	molecular_function	"Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + succinate." [EC:3.5.1.18, RHEA:22611]
EOG82NMDN	GO:0004180	2/98	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG82NMDN	GO:0016787	2/98	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG82NMDN	GO:0005576	1/98	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8TTK01	GO:0004252	46/163	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8TTK01	GO:0003824	4/163	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8TTK00	GO:0004751	26/89	ribose-5-phosphate isomerase activity	molecular_function	"Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.6, RHEA:14660]
EOG8TTK00	GO:0009052	26/89	pentose-phosphate shunt, non-oxidative branch	biological_process	"The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732, MetaCyc:NONOXIPENT-PWY]
EOG8TTK00	GO:0001315	1/89	age-dependent response to reactive oxygen species	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938]
EOG8TTK03	GO:0005549	21/96	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8TTK03	GO:0004984	21/96	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8TTK03	GO:0004930	17/96	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8TTK03	GO:0016021	17/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TTK03	GO:0005886	8/96	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8TTK03	GO:0016020	4/96	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82NMD4	GO:0045177	1/151	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG82NMD4	GO:0030424	1/151	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG82NMD4	GO:0005938	1/151	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG82NMD4	GO:0035316	1/151	non-sensory hair organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis." [GOC:mtg_sensu, PMID:11064425]
EOG82NMD4	GO:0035317	1/151	imaginal disc-derived wing hair organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853]
EOG82NMD4	GO:0045860	1/151	positive regulation of protein kinase activity	biological_process	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
EOG82NMD4	GO:0044297	1/151	cell body	cellular_component	"The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]
EOG82NMD4	GO:0005515	1/151	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG82NMD4	GO:0048800	1/151	antennal morphogenesis	biological_process	"The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid]
EOG82NMD4	GO:0030425	1/151	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG82NMD4	GO:0050773	1/151	regulation of dendrite development	biological_process	"Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai]
EOG82NMD4	GO:0008407	1/151	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG82NMD4	GO:0007476	1/151	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG82NMD4	GO:0048601	1/151	oocyte morphogenesis	biological_process	"The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators]
EOG82NMD4	GO:0042052	1/151	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG82NMD4	GO:0005737	1/151	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82NMD4	GO:0070593	1/151	dendrite self-avoidance	biological_process	"The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551]
EOG82NMD4	GO:0048814	1/151	regulation of dendrite morphogenesis	biological_process	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG82NMD4	GO:0045893	1/151	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82NMD4	GO:0006351	1/151	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8WHC23	GO:0042254	23/95	ribosome biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
EOG8WHC23	GO:0030529	17/95	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8WHC23	GO:0005840	7/95	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8WHC23	GO:0051298	1/95	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8WHC23	GO:0051297	1/95	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8WHC23	GO:0003735	1/95	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8WHC23	GO:0007052	1/95	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8WHC23	GO:0000022	1/95	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG883GMB	GO:0005634	1/91	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG883GMB	GO:0005829	1/91	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG883GMB	GO:0006412	1/91	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG85QKT2	GO:0005524	4/94	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG85QKT2	GO:0017111	3/94	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG85QKT2	GO:0003677	2/94	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG85QKT2	GO:0043025	1/94	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG85QKT2	GO:0045202	1/94	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG85QKT2	GO:0030424	1/94	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG85QKT2	GO:0005515	1/94	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG85QKT2	GO:0032508	1/94	DNA duplex unwinding	biological_process	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]
EOG85QKT2	GO:0000184	1/94	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	biological_process	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]
EOG85QKT2	GO:0007616	1/94	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG85QKT2	GO:0000578	1/94	embryonic axis specification	biological_process	"The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb]
EOG85QKT2	GO:0007318	1/94	pole plasm protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
EOG85QKT2	GO:0003678	1/94	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG85QKT2	GO:0030425	1/94	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG85QKT2	GO:0046843	1/94	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG85QKT2	GO:0016246	1/94	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG85QKT2	GO:0031023	1/94	microtubule organizing center organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah]
EOG85QKT2	GO:0070725	1/94	Yb body	cellular_component	"A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell." [GOC:sart, PMID:19433453]
EOG85QKT2	GO:0005737	1/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG85QKT2	GO:0004386	1/94	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8KH59V	GO:0016021	6/48	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80GG7V	GO:0015031	18/54	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG80GG7V	GO:0046872	18/54	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80GG7V	GO:0005739	17/54	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG80GG7V	GO:0005743	1/54	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG80GG7V	GO:0071456	1/54	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG8KH59Q	GO:0004129	45/129	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8KH59Q	GO:0004252	1/129	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8KH59Q	GO:0000278	1/129	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8KH59Q	GO:0005739	1/129	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8KH59Q	GO:0005811	1/129	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8KH59Q	GO:0007030	1/129	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8KH59Q	GO:0008283	1/129	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG886BSN	GO:0000042	21/62	protein targeting to Golgi	biological_process	"The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah]
EOG886BSN	GO:0032440	1/62	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG886BSN	GO:0042803	1/62	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG886BSN	GO:0000138	1/62	Golgi trans cisterna	cellular_component	"The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194]
EOG886BSN	GO:0030306	1/62	ADP-ribosylation factor binding	molecular_function	"Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells." [ISBN:0198506732]
EOG886BSN	GO:0048193	1/62	Golgi vesicle transport	biological_process	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG886BSN	GO:0017137	1/62	Rab GTPase binding	molecular_function	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG8KH59F	GO:0042052	1/98	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8KH59F	GO:0031468	1/98	nuclear envelope reassembly	biological_process	"The reformation of the nuclear envelope following its breakdown in the context of a normal process." [GOC:mah]
EOG8SBHFN	GO:0007218	1/31	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8SBHFN	GO:0005184	1/31	neuropeptide hormone activity	molecular_function	"The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]
EOG8SBHFN	GO:0045823	1/31	positive regulation of heart contraction	biological_process	"Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators]
EOG8SBHFN	GO:0005576	1/31	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8KH59N	GO:0005634	16/44	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8KH59N	GO:0018024	15/44	histone-lysine N-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]
EOG8KH59N	GO:0005694	14/44	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8KH59N	GO:0008270	14/44	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KH59N	GO:0008168	1/44	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG81NX0X	GO:0007112	1/103	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG81NX0X	GO:0048137	1/103	spermatocyte division	biological_process	"The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238]
EOG81NX0X	GO:0000916	1/103	actomyosin contractile ring contraction	biological_process	"The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb]
EOG81NX0X	GO:0036063	1/103	acroblast	cellular_component	"A cone-shaped structure in the head of a spermatozoon, which is formed by the coalescence of Golgi fragments following the completion of meiosis. The acroblast is situated adjacent to the acrosomal vesicle." [GOC:sart, PMID:19934220]
EOG81NX0X	GO:0007111	1/103	meiosis II cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG81NX0X	GO:0005794	1/103	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG81NX0X	GO:0007110	1/103	meiosis I cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG81NX0X	GO:0005737	1/103	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG81NX0X	GO:0043147	1/103	meiotic spindle stabilization	biological_process	"The cell cycle process in which spindle integrity is maintained during M phase of meiosis." [GOC:go_curators]
EOG8VMHV6	GO:0005524	2/148	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VMHV6	GO:0003677	2/148	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8VMHV6	GO:0050254	1/148	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8VMHV6	GO:0005887	1/148	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VMHV6	GO:0016480	1/148	negative regulation of transcription from RNA polymerase III promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter." [GOC:go_curators]
EOG8VMHV6	GO:0004386	1/148	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8VMHV6	GO:0016162	1/148	cellulose 1,4-beta-cellobiosidase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91]
EOG8KPWQX	GO:0005509	8/49	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG80VZ66	GO:0003677	1/9	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80VZ66	GO:0003700	1/9	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8N06X7	GO:0003964	1/24	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8N06X7	GO:0003723	1/24	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8KPWQV	GO:0046872	15/102	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8KPWQV	GO:0008253	3/102	5'-nucleotidase activity	molecular_function	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]
EOG8XPT01	GO:0003676	15/34	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XPT01	GO:0015074	15/34	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8XPT01	GO:0003964	1/34	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8XPT01	GO:0016787	1/34	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8XPT01	GO:0003723	1/34	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8GMXB0	GO:0008233	12/66	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8NCPWH	GO:0000166	13/97	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8NCPWH	GO:0008270	13/97	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NCPWH	GO:0003676	13/97	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NCPWH	GO:0007303	1/97	cytoplasmic transport, nurse cell to oocyte	biological_process	"The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238]
EOG8NCPWH	GO:0005634	1/97	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NCPWH	GO:0045475	1/97	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8NCPWH	GO:0071011	1/97	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8NCPWH	GO:0008062	1/97	eclosion rhythm	biological_process	"The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043]
EOG8NCPWH	GO:0007067	1/97	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8NCPWH	GO:0003723	1/97	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8NCPWH	GO:0007562	1/97	eclosion	biological_process	"The emergence of an adult insect from a pupa case." [GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461]
EOG8NCPWH	GO:0071013	1/97	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8NCPWH	GO:0000398	1/97	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8NCPWH	GO:0030036	1/97	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8NCPWH	GO:0005737	1/97	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8NCPWH	GO:0008104	1/97	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8NCPWH	GO:0045804	1/97	negative regulation of eclosion	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of eclosion." [GOC:go_curators]
EOG8NCPWH	GO:0009790	1/97	embryo development	biological_process	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
EOG8NCPWH	GO:0007623	1/97	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG8NCPWH	GO:0003729	1/97	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8BVV7K	GO:0006419	28/107	alanyl-tRNA aminoacylation	biological_process	"The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8BVV7K	GO:0005524	28/107	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8BVV7K	GO:0004813	28/107	alanine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7]
EOG8BVV7K	GO:0005737	25/107	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8BVV7K	GO:0003676	24/107	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BVV7K	GO:0003743	3/107	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8BVV7K	GO:0005525	3/107	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8BVV7K	GO:0000049	1/107	tRNA binding	molecular_function	"Interacting selectively and non-covalently with transfer RNA." [GOC:ai]
EOG8BVV7K	GO:0046872	1/107	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8BVV7K	GO:0005622	1/107	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8DRCSN	GO:0003723	10/55	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8DRCSN	GO:0003964	10/55	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8DRCSN	GO:0015074	6/55	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8DRCSN	GO:0008270	6/55	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DRCSN	GO:0003676	2/55	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DRCSN	GO:0004190	1/55	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG82JR61	GO:0005576	22/89	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG82JR61	GO:0006629	22/89	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG82JR61	GO:0016787	20/89	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG82JR61	GO:0004806	1/89	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG82JR61	GO:0003824	1/89	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG82JR64	GO:0005634	65/228	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82JR64	GO:0006351	60/228	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG82JR64	GO:0007275	58/228	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG82JR64	GO:0003700	57/228	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG82JR64	GO:0043565	44/228	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG82JR64	GO:0000976	11/228	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG82JR64	GO:0003677	9/228	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG82JR64	GO:0006355	8/228	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82JR64	GO:0000977	3/228	RNA polymerase II regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
EOG82JR64	GO:0007367	2/228	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG82JR64	GO:0022008	2/228	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG82JR64	GO:0007366	1/228	periodic partitioning by pair rule gene	biological_process	"Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG82JR64	GO:0007435	1/228	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG82JR64	GO:0005737	1/228	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82JR64	GO:0045944	1/228	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG82JR64	GO:0007419	1/228	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG82JR64	GO:0060025	1/228	regulation of synaptic activity	biological_process	"Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell." [GOC:dph, GOC:tb]
EOG82JR64	GO:0004000	1/228	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG82JR64	GO:0006366	1/228	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG82JR64	GO:0003705	1/228	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG82JR64	GO:0007268	1/228	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8BVV7F	GO:0005507	45/236	copper ion binding	molecular_function	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]
EOG8BVV7F	GO:0016715	41/236	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
EOG8BVV7F	GO:0004500	4/236	dopamine beta-monooxygenase activity	molecular_function	"Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O." [EC:1.14.17.1, RHEA:19120]
EOG8BVV7F	GO:0008345	1/236	larval locomotory behavior	biological_process	"Locomotory behavior in a larval (immature) organism." [GOC:ai]
EOG8BVV7F	GO:0016021	1/236	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BVV7F	GO:0006589	1/236	octopamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732]
EOG8BVV7F	GO:0043059	1/236	regulation of forward locomotion	biological_process	"Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism." [GOC:go_curators]
EOG8BVV7F	GO:0008049	1/236	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8BVV7F	GO:0002121	1/236	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8BVV7F	GO:0007612	1/236	learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544]
EOG8BVV7F	GO:0040011	1/236	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG8BVV7F	GO:0055114	1/236	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8BVV7F	GO:0030728	1/236	ovulation	biological_process	"The release of a mature ovum/oocyte from an ovary." [GOC:bf, ISBN:0878932437]
EOG8BVV7F	GO:0006355	1/236	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8BVV7F	GO:0048047	1/236	mating behavior, sex discrimination	biological_process	"The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700]
EOG8BVV7F	GO:0071927	1/236	octopamine signaling pathway	biological_process	"The series of molecular signals generated as a consequence of octopamine binding to a cell surface receptor." [GOC:mah, PMID:15355245]
EOG8BVV7F	GO:0003677	1/236	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8BVV7F	GO:0005576	1/236	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8BVV7F	GO:0034472	1/236	snRNA 3'-end processing	biological_process	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]
EOG8BVV7F	GO:0007613	1/236	memory	biological_process	"The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089]
EOG8BVV7F	GO:0050795	1/236	regulation of behavior	biological_process	"Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr]
EOG8BVV7F	GO:0007629	1/236	flight behavior	biological_process	"The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
EOG8BVV7F	GO:0002118	1/236	aggressive behavior	biological_process	"A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd]
EOG8BVV7F	GO:0048149	1/236	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8CG2R8	GO:0003676	293/3952	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CG2R8	GO:0015074	167/3952	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8CG2R8	GO:0008270	165/3952	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CG2R8	GO:0003723	66/3952	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CG2R8	GO:0003964	66/3952	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8CG2R8	GO:0004190	48/3952	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8CG2R8	GO:0005634	3/3952	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CG2R8	GO:0005509	3/3952	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8CG2R8	GO:0003677	3/3952	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CG2R8	GO:0016021	2/3952	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CG2R8	GO:0007166	2/3952	cell surface receptor signaling pathway	biological_process	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
EOG8CG2R8	GO:0004842	2/3952	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8CG2R8	GO:0023051	2/3952	regulation of signaling	biological_process	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
EOG8CG2R8	GO:0046872	2/3952	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CG2R8	GO:0004871	2/3952	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8CG2R8	GO:0003700	1/3952	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8CG2R8	GO:0016620	1/3952	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG8CG2R8	GO:0004527	1/3952	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8CG2R8	GO:0005524	1/3952	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CG2R8	GO:0055085	1/3952	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8CG2R8	GO:0043565	1/3952	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8CG2R8	GO:0004518	1/3952	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8CG2R8	GO:0004672	1/3952	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8CG2R8	GO:0004725	1/3952	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8CG2R8	GO:0005840	1/3952	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8CG2R8	GO:0006412	1/3952	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8CG2R8	GO:0022857	1/3952	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8CG2R8	GO:0019031	1/3952	viral envelope	cellular_component	"The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope]
EOG8CG2R8	GO:0003735	1/3952	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8CG2R8	GO:0016491	1/3952	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8CG2R8	GO:0005975	1/3952	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8DRCSQ	GO:0016021	19/71	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DRCSQ	GO:0005743	19/71	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8DRCSQ	GO:0005509	3/71	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8DRCSQ	GO:0005739	1/71	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8DRCSQ	GO:0022008	1/71	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8S1WP5	GO:0006457	25/85	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8S1WP5	GO:0000502	2/85	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG8S1WP5	GO:0005515	1/85	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8S1WP5	GO:0006974	1/85	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8S1WPM	GO:0003676	4/15	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8N5Z9W	GO:0031011	25/90	Ino80 complex	cellular_component	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820]
EOG8HB13F	GO:0003676	3/25	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HB13F	GO:0015074	2/25	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8HB13F	GO:0008270	1/25	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8HB13F	GO:0003964	1/25	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8STVKD	GO:0003682	11/89	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8STVKD	GO:0005739	4/89	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8STVKD	GO:0045980	4/89	negative regulation of nucleotide metabolic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators]
EOG8STVKD	GO:0004857	4/89	enzyme inhibitor activity	molecular_function	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai]
EOG8STVKD	GO:0046426	1/89	negative regulation of JAK-STAT cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG8STVKD	GO:0007274	1/89	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8STVKD	GO:0003700	1/89	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8STVKD	GO:0005634	1/89	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8STVKD	GO:0010468	1/89	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8STVKD	GO:0005515	1/89	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8STVKD	GO:0007319	1/89	negative regulation of oskar mRNA translation	biological_process	"Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems]
EOG8STVKD	GO:0007428	1/89	primary branching, open tracheal system	biological_process	"Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG8STVKD	GO:0043565	1/89	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8STVKD	GO:0007427	1/89	epithelial cell migration, open tracheal system	biological_process	"The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8STVKD	GO:0035289	1/89	posterior head segmentation	biological_process	"Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136]
EOG8STVKD	GO:0005737	1/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8STVKD	GO:0007298	1/89	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8STVKD	GO:0003730	1/89	mRNA 3'-UTR binding	molecular_function	"Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah]
EOG8STVKD	GO:0001158	1/89	enhancer sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH]
EOG8STVKD	GO:0046011	1/89	regulation of oskar mRNA translation	biological_process	"Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512]
EOG8STVKD	GO:0007417	1/89	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8STVKD	GO:0045944	1/89	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8STVKD	GO:0003729	1/89	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8STVKD	GO:0007507	1/89	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8STVKD	GO:0048149	1/89	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8STVKD	GO:0007424	1/89	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8S1WPX	GO:0046872	2/20	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DRCS4	GO:0016787	1/38	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8DRCS4	GO:0005856	1/38	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8PK4RD	GO:0016012	30/113	sarcoglycan complex	cellular_component	"A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609]
EOG8PK4RD	GO:0016021	30/113	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PK4RD	GO:0060047	1/113	heart contraction	biological_process	"The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph]
EOG8PK4RD	GO:0043034	1/113	costamere	cellular_component	"Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732, PMID:6405378]
EOG8PK4RD	GO:0045214	1/113	sarcomere organization	biological_process	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
EOG8PK4RD	GO:0007498	1/113	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8PK4RD	GO:0007016	1/113	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG86MDZQ	GO:0004561	2/92	alpha-N-acetylglucosaminidase activity	molecular_function	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides." [EC:3.2.1.50]
EOG86MDZQ	GO:0005975	1/92	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8909T3	GO:0003964	5/21	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8909T3	GO:0003723	5/21	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8909T3	GO:0015074	1/21	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8909T3	GO:0004190	1/21	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8RZ1FG	GO:0003723	2/10	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RZ1FG	GO:0003964	2/10	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8RZ1FG	GO:0004519	1/10	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8S1WPT	GO:0008270	4/10	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8S1WPT	GO:0016832	4/10	aldehyde-lyase activity	molecular_function	"Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [http://www.mercksource.com/]
EOG8S1WPT	GO:0005975	4/10	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8S1WPT	GO:0016020	1/10	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8S1WPT	GO:0005215	1/10	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8S1WPT	GO:0055085	1/10	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG82JR6D	GO:0003824	21/67	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8BK7JX	GO:0003700	24/84	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8BK7JX	GO:0005634	24/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BK7JX	GO:0043565	23/84	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8BK7JX	GO:0000976	1/84	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8BK7JX	GO:0007417	1/84	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8BK7JX	GO:0007419	1/84	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8BK7JX	GO:0008134	1/84	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8BK7JX	GO:0000122	1/84	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8BK7JX	GO:0007420	1/84	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG8BK7JX	GO:0007400	1/84	neuroblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
EOG8BK7JX	GO:0009953	1/84	dorsal/ventral pattern formation	biological_process	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8BK7JX	GO:0010629	1/84	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8BK7JX	GO:0007389	1/84	pattern specification process	biological_process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
EOG8BK7JX	GO:0007398	1/84	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG8BK7JX	GO:0006357	1/84	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG896261	GO:0005856	22/91	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG896261	GO:0008092	1/91	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8BK7JP	GO:0008270	14/62	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BK7JP	GO:0003676	10/62	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BK7JP	GO:0008168	4/62	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8N06XW	GO:0016021	3/7	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8N06XW	GO:0006633	2/7	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8N06XW	GO:0016740	2/7	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG80VZ6F	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8H48KG	GO:0016491	77/201	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8H48KG	GO:0004316	5/201	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
EOG8BK7JB	GO:0003824	3/83	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8H48KC	GO:0016020	1/6	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8H48KC	GO:0016705	1/6	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8H48KC	GO:0005215	1/6	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8H48KB	GO:0016021	9/61	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8H48KB	GO:0005375	9/61	copper ion transmembrane transporter activity	molecular_function	"Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai]
EOG8PCD7T	GO:0003676	2/25	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FN6XK	GO:0005524	23/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8FN6XK	GO:0004713	20/91	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8FN6XK	GO:0007156	4/91	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8FN6XK	GO:0005509	4/91	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8FN6XK	GO:0005886	3/91	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8FN6XK	GO:0004714	3/91	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8FN6XK	GO:0016020	3/91	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8FN6XK	GO:0005887	1/91	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FN6XK	GO:0006468	1/91	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8FN6XK	GO:0007165	1/91	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8FN6XK	GO:0004672	1/91	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8FN6XK	GO:0007155	1/91	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8FN6XK	GO:0018108	1/91	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG8J3ZX3	GO:0016998	22/123	cell wall macromolecule catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators]
EOG8J3ZX3	GO:0003824	3/123	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8J3ZX3	GO:0050829	1/123	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8J3ZX3	GO:0005634	1/123	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8J3ZX3	GO:0002218	1/123	activation of innate immune response	biological_process	"Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805]
EOG8J3ZX3	GO:0007476	1/123	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8J3ZX3	GO:0005737	1/123	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82C0Q8	GO:0005921	88/279	gap junction	cellular_component	"A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181]
EOG82C0Q8	GO:0006811	88/279	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG82C0Q8	GO:0016021	88/279	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82C0Q8	GO:0005243	5/279	gap junction channel activity	molecular_function	"A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes." [GOC:dgh, GOC:mtg_transport, ISBN:0815340729]
EOG82C0Q8	GO:0055085	5/279	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG82C0Q8	GO:0005886	4/279	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG82C0Q8	GO:0016264	3/279	gap junction assembly	biological_process	"Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids." [GOC:jid, ISBN:0716731363]
EOG82C0Q8	GO:0009881	3/279	photoreceptor activity	molecular_function	"The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators]
EOG82C0Q8	GO:0009416	3/279	response to light stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
EOG82C0Q8	GO:0007602	2/279	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG82C0Q8	GO:0016323	2/279	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG82C0Q8	GO:0007165	2/279	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG82C0Q8	GO:0010644	1/279	cell communication by electrical coupling	biological_process	"The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
EOG82C0Q8	GO:0016324	1/279	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG82C0Q8	GO:0007440	1/279	foregut morphogenesis	biological_process	"The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid]
EOG82C0Q8	GO:0010496	1/279	intercellular transport	biological_process	"The movement of substances between cells." [GOC:dhl]
EOG82C0Q8	GO:0007630	1/279	jump response	biological_process	"The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jid, ISBN:0198606907]
EOG82C0Q8	GO:0005737	1/279	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82C0Q8	GO:0030727	1/279	germarium-derived female germ-line cyst formation	biological_process	"Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902]
EOG82C0Q8	GO:0007154	1/279	cell communication	biological_process	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]
EOG82C0Q8	GO:0016328	1/279	lateral plasma membrane	cellular_component	"The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr]
EOG82C0Q8	GO:0007293	1/279	germarium-derived egg chamber formation	biological_process	"Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG82C0Q8	GO:0016331	1/279	morphogenesis of embryonic epithelium	biological_process	"The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl]
EOG82C0Q8	GO:0042048	1/279	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG82C0Q8	GO:0003254	1/279	regulation of membrane depolarization	biological_process	"Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb]
EOG82C0Q8	GO:0007632	1/279	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG82C0Q8	GO:0016327	1/279	apicolateral plasma membrane	cellular_component	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
EOG82C0Q4	GO:0046872	32/102	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82C0Q4	GO:0003676	30/102	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82C0Q4	GO:0016458	2/102	gene silencing	biological_process	"Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb]
EOG82C0Q4	GO:0043565	2/102	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG82C0Q4	GO:0005634	2/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82C0Q4	GO:0005515	2/102	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG82C0Q4	GO:0003677	2/102	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG82C0Q4	GO:0005704	1/102	polytene chromosome band	cellular_component	"A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342]
EOG82C0Q4	GO:0006355	1/102	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82C0Q4	GO:0006310	1/102	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG82C0Q4	GO:0010629	1/102	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG82C0Q4	GO:0031011	1/102	Ino80 complex	cellular_component	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820]
EOG82C0Q4	GO:0006342	1/102	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG82C0Q4	GO:0048813	1/102	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG82C0Q4	GO:0045892	1/102	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82C0Q4	GO:0000980	1/102	RNA polymerase II distal enhancer sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH]
EOG82C0Q4	GO:0003682	1/102	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG82C0Q4	GO:0000790	1/102	nuclear chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130]
EOG82C0Q4	GO:0048096	1/102	chromatin-mediated maintenance of transcription	biological_process	"Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable." [GOC:jid]
EOG82C0Q4	GO:0005703	1/102	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG82C0Q4	GO:0006281	1/102	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG82C0Q4	GO:0006351	1/102	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG82C0Q4	GO:0006265	1/102	DNA topological change	biological_process	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]
EOG82C0Q4	GO:0031490	1/102	chromatin DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah]
EOG82C0Q4	GO:0005700	1/102	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8ZKN4J	GO:0003677	3/7	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8ZKN4J	GO:0003700	3/7	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8TXF9N	GO:0008234	6/15	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8TXF9N	GO:0008270	6/15	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X3KH3	GO:0017061	37/160	S-methyl-5-thioadenosine phosphorylase activity	molecular_function	"Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28]
EOG8X3KH3	GO:0004645	37/160	phosphorylase activity	molecular_function	"Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase." [EC:2.4.1.1]
EOG8X3KH3	GO:0005737	36/160	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8X3KH3	GO:0005634	36/160	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X3KH3	GO:0006166	36/160	purine ribonucleoside salvage	biological_process	"Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl]
EOG8X3KH3	GO:0019509	24/160	L-methionine biosynthetic process from methylthioadenosine	biological_process	"The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361]
EOG8X3KH3	GO:0004731	12/160	purine-nucleoside phosphorylase activity	molecular_function	"Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1]
EOG8X3KH3	GO:0009116	2/160	nucleoside metabolic process	biological_process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]
EOG8X3KH3	GO:0003824	1/160	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8PRW52	GO:0005089	16/67	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8PRW52	GO:0035556	11/67	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8PRW52	GO:0005524	4/67	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8PRW52	GO:0004674	2/67	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8PRW52	GO:0004713	1/67	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8PRW52	GO:0004672	1/67	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8PRW52	GO:0004683	1/67	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG80041M	GO:0004950	1/11	chemokine receptor activity	molecular_function	"Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, http://en.wikipedia.org/wiki/Chemokine, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823]
EOG80041M	GO:0006935	1/11	chemotaxis	biological_process	"The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732]
EOG80041M	GO:0016021	1/11	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DJNC5	GO:0016747	1/24	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8ZKN4Q	GO:0003964	1/3	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8ZKN4Q	GO:0003723	1/3	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG85QKSZ	GO:0005509	4/26	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8HTC8S	GO:0005681	1/80	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8HTC8S	GO:0030532	1/80	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8HTC8S	GO:0005688	1/80	U6 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U6." [GOC:krc, GOC:mah]
EOG8HTC8S	GO:0005515	1/80	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8HTC8S	GO:0000398	1/80	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG84N15S	GO:0007317	1/101	regulation of pole plasm oskar mRNA localization	biological_process	"Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb]
EOG84N15W	GO:0008236	24/112	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG84N15W	GO:0016020	24/112	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG84N15W	GO:0006508	3/112	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8577N9	GO:0046080	5/13	dUTP metabolic process	biological_process	"The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators]
EOG8577N9	GO:0004170	4/13	dUTP diphosphatase activity	molecular_function	"Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [EC:3.6.1.23]
EOG8577N9	GO:0015941	1/13	pantothenate catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544]
EOG8577N9	GO:0010181	1/13	FMN binding	molecular_function	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]
EOG8577N9	GO:0004633	1/13	phosphopantothenoylcysteine decarboxylase activity	molecular_function	"Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate." [EC:4.1.1.36, RHEA:16796]
EOG8577N9	GO:0016787	1/13	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8577N9	GO:0004632	1/13	phosphopantothenate--cysteine ligase activity	molecular_function	"Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5]
EOG8577N9	GO:0015937	1/13	coenzyme A biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
EOG8577N7	GO:0005097	13/64	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG82C0QT	GO:0003676	21/60	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82C0QT	GO:0046872	21/60	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Q87DC	GO:0040007	9/56	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG8Q87DC	GO:0005576	3/56	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG88KTS7	GO:0043565	26/94	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG88KTS7	GO:0005634	26/94	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88KTS7	GO:0003700	24/94	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG88KTS7	GO:0000981	1/94	RNA polymerase II transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
EOG88KTS7	GO:0005515	1/94	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG88KTS7	GO:0061320	1/94	pericardial nephrocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]
EOG88KTS7	GO:0061331	1/94	epithelial cell proliferation involved in Malpighian tubule morphogenesis	biological_process	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG88KTS7	GO:0007422	1/94	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG88KTS7	GO:0007464	1/94	R3/R4 cell fate commitment	biological_process	"The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
EOG88KTS7	GO:0007427	1/94	epithelial cell migration, open tracheal system	biological_process	"The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG88KTS7	GO:0060439	1/94	trachea morphogenesis	biological_process	"The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG88KTS7	GO:0007362	1/94	terminal region determination	biological_process	"Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG88KTS7	GO:0007265	1/94	Ras protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf]
EOG88KTS7	GO:0006366	1/94	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG88KTS7	GO:0009997	1/94	negative regulation of cardioblast cell fate specification	biological_process	"Any process that restricts, stops or prevents a cell from specifying into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG88KTS7	GO:0008293	1/94	torso signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
EOG88KTS7	GO:0007173	1/94	epidermal growth factor receptor signaling pathway	biological_process	"A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933]
EOG88KTS7	GO:0050767	1/94	regulation of neurogenesis	biological_process	"Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]
EOG88KTS7	GO:0045944	1/94	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG88KTS7	GO:0030707	1/94	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG88KTS7	GO:0008284	1/94	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG88KTS7	GO:0060438	1/94	trachea development	biological_process	"The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG88KTS7	GO:0007476	1/94	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG88KTS7	GO:0007507	1/94	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG88KTS7	GO:0007424	1/94	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG88KTS7	GO:0007429	1/94	secondary branching, open tracheal system	biological_process	"Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG88KTS7	GO:0006909	1/94	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG88KTS7	GO:0007426	1/94	tracheal outgrowth, open tracheal system	biological_process	"The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG88KTS7	GO:0070491	1/94	repressing transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH]
EOG88KTS7	GO:0045610	1/94	regulation of hemocyte differentiation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG88KTS7	GO:0035225	1/94	determination of genital disc primordium	biological_process	"Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318]
EOG88KTS7	GO:0007428	1/94	primary branching, open tracheal system	biological_process	"Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG88KTS7	GO:0048190	1/94	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG88KTS7	GO:0045467	1/94	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG88KTS7	GO:0048747	1/94	muscle fiber development	biological_process	"The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
EOG88KTS7	GO:2001234	1/94	negative regulation of apoptotic signaling pathway	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]
EOG88KTS7	GO:0007455	1/94	eye-antennal disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8577N0	GO:0003887	25/85	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8577N0	GO:0003677	25/85	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8577N0	GO:0005634	15/85	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8577N0	GO:0005635	1/85	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG8577N0	GO:0046982	1/85	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8577N0	GO:0006261	1/85	DNA-dependent DNA replication	biological_process	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]
EOG8577N0	GO:0006270	1/85	DNA replication initiation	biological_process	"The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194]
EOG8577N0	GO:0005658	1/85	alpha DNA polymerase:primase complex	cellular_component	"A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402]
EOG82C0QN	GO:0016746	5/45	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8X99ZW	GO:0005524	3/20	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X99ZW	GO:0006281	2/20	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8X99ZW	GO:0003678	2/20	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8X99ZW	GO:0000723	2/20	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8X99ZW	GO:0004386	1/20	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8TF323	GO:0008138	24/86	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG8TF323	GO:0004725	23/86	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8TF323	GO:0006470	2/86	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8J3ZXD	GO:0003779	1/92	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8J3ZXD	GO:0009913	1/92	epidermal cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]
EOG8J3ZXD	GO:0035317	1/92	imaginal disc-derived wing hair organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853]
EOG8J3ZXD	GO:0051017	1/92	actin filament bundle assembly	biological_process	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
EOG8J3ZXD	GO:0035017	1/92	cuticle pattern formation	biological_process	"The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf]
EOG8J3ZXD	GO:0008407	1/92	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG8J3ZXD	GO:0007605	1/92	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8J3ZXD	GO:0048800	1/92	antennal morphogenesis	biological_process	"The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid]
EOG8MSGGG	GO:0003676	2/235	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MSGGG	GO:0005524	2/235	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8MSGGG	GO:0006094	1/235	gluconeogenesis	biological_process	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]
EOG8MSGGG	GO:0003968	1/235	RNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah]
EOG8MSGGG	GO:0004736	1/235	pyruvate carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847]
EOG8MSGGG	GO:0004075	1/235	biotin carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]
EOG8MSGGG	GO:0003964	1/235	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8MSGGG	GO:0008026	1/235	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8MSGGG	GO:0019079	1/235	viral genome replication	biological_process	"Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534]
EOG8QRKM7	GO:0008553	1/73	hydrogen-exporting ATPase activity, phosphorylative mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle." [EC:3.6.3.6]
EOG88SK6Z	GO:0016021	22/94	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG837TX1	GO:0003677	1/22	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DBWX7	GO:0000737	1/76	DNA catabolic process, endonucleolytic	biological_process	"The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
EOG8DBWX7	GO:0003906	1/76	DNA-(apurinic or apyrimidinic site) lyase activity	molecular_function	"Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18]
EOG8DBWX7	GO:0046872	1/76	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DBWX7	GO:0090305	1/76	nucleic acid phosphodiester bond hydrolysis	biological_process	"The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
EOG8DBWX7	GO:0004520	1/76	endodeoxyribonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8DBWX7	GO:0008408	1/76	3'-5' exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]
EOG8DBWX0	GO:0003723	15/68	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG81ZHT5	GO:0006313	1/37	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG81ZHT5	GO:0015074	1/37	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG81ZHT5	GO:0003677	1/37	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81ZHT5	GO:0004803	1/37	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG8VDSFF	GO:0016020	35/2018	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8VDSFF	GO:0051781	22/2018	positive regulation of cell division	biological_process	"Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai]
EOG8VDSFF	GO:0007435	2/2018	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8VDSFF	GO:0035099	2/2018	hemocyte migration	biological_process	"The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551]
EOG8VDSFF	GO:0003964	1/2018	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8VDSFF	GO:0008039	1/2018	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8VDSFF	GO:0035172	1/2018	hemocyte proliferation	biological_process	"The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG8B2WDC	GO:0003677	3/350	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8B2WDC	GO:0004518	2/350	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8B2WDC	GO:0016747	1/350	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8B2WDC	GO:0004527	1/350	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG84TRNR	GO:0005234	25/99	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG84TRNR	GO:0004970	24/99	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG84TRNR	GO:0016020	13/99	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG84TRNR	GO:0016021	12/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84TRNR	GO:0034220	1/99	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG84TRNR	GO:0036081	1/99	extracellular ammonia-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
EOG84TRNR	GO:0050907	1/99	detection of chemical stimulus involved in sensory perception	biological_process	"The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
EOG84TRNR	GO:0006370	1/99	7-methylguanosine mRNA capping	biological_process	"Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685]
EOG84TRNR	GO:0005886	1/99	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG84TRNR	GO:0015276	1/99	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG84TRNR	GO:0004484	1/99	mRNA guanylyltransferase activity	molecular_function	"Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50]
EOG84TRNQ	GO:0005634	21/94	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84TRNQ	GO:0006886	21/94	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG84TRNQ	GO:0005737	1/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84TRNQ	GO:0003964	1/94	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG84TRNQ	GO:0005815	1/94	microtubule organizing center	cellular_component	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416]
EOG84TRNQ	GO:0003682	1/94	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG84TRNQ	GO:0005049	1/94	nuclear export signal receptor activity	molecular_function	"Combining with a nuclear export signal (NES) to mediate transport of the NES-containing protein through the nuclear pore to the cytoplasm." [GOC:bf, GOC:mah, GOC:vw, PMID:11743003, PMID:12486120]
EOG84TRNQ	GO:0000922	1/94	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG84TRNQ	GO:0003677	1/94	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84TRNQ	GO:0000226	1/94	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG84TRNQ	GO:0003723	1/94	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG84TRNQ	GO:0006352	1/94	DNA-templated transcription, initiation	biological_process	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]
EOG84TRNQ	GO:0005643	1/94	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG84TRNQ	GO:0051028	1/94	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84TRNQ	GO:0006611	1/94	protein export from nucleus	biological_process	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]
EOG8ZSCHK	GO:0050661	87/284	NADP binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]
EOG8ZSCHK	GO:0004499	87/284	N,N-dimethylaniline monooxygenase activity	molecular_function	"Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8]
EOG8ZSCHK	GO:0050660	87/284	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8ZSCHK	GO:0005789	9/284	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8ZSCHK	GO:0005829	2/284	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8ZSCHK	GO:0004497	2/284	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8ZSCHK	GO:0005739	2/284	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8ZSCHK	GO:0043231	2/284	intracellular membrane-bounded organelle	cellular_component	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
EOG8ZSCHK	GO:0016021	1/284	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZSCHK	GO:0016042	1/284	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8ZSCHK	GO:0045454	1/284	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8ZSCHK	GO:0003847	1/284	1-alkyl-2-acetylglycerophosphocholine esterase activity	molecular_function	"Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]
EOG8ZSCHR	GO:0046331	1/96	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8ZSCHR	GO:0016905	1/96	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG80S2WJ	GO:0016491	161/516	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG80S2WJ	GO:0004032	11/516	alditol:NADP+ 1-oxidoreductase activity	molecular_function	"Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21]
EOG80S2WJ	GO:0035220	1/516	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG80S2WJ	GO:0047006	1/516	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	molecular_function	"Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone." [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN]
EOG80S2WJ	GO:0016319	1/516	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG80S2WJ	GO:0008106	1/516	alcohol dehydrogenase (NADP+) activity	molecular_function	"Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2]
EOG80S2WJ	GO:0022416	1/516	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG84TRNM	GO:0003713	4/44	transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG84TRNM	GO:0005634	4/44	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CZDW8	GO:0005524	45/139	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CZDW8	GO:0008568	43/139	microtubule-severing ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766]
EOG8CZDW8	GO:0051013	43/139	microtubule severing	biological_process	"The process in which a microtubule is broken down into smaller segments." [GOC:ai, PMID:14657234]
EOG8CZDW8	GO:0005813	41/139	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8CZDW8	GO:0030496	41/139	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG8CZDW8	GO:0000922	41/139	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8CZDW8	GO:0005874	41/139	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8CZDW8	GO:0007126	41/139	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8CZDW8	GO:0005737	39/139	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CZDW8	GO:0008017	2/139	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8CZDW8	GO:0008352	2/139	katanin complex	cellular_component	"A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766]
EOG8CZDW8	GO:0007017	2/139	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8CZDW8	GO:0017111	1/139	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8CZDW8	GO:0031252	1/139	cell leading edge	cellular_component	"The area of a motile cell closest to the direction of movement." [GOC:pg]
EOG8CZDW8	GO:0005694	1/139	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8CZDW8	GO:0016358	1/139	dendrite development	biological_process	"The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8CZDW8	GO:0005938	1/139	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8CZDW8	GO:0070462	1/139	plus-end specific microtubule depolymerization	biological_process	"The removal of tubulin heterodimers from the plus end of a microtubule." [GOC:krc, PMID:16906145, PMID:16906148]
EOG8CZDW8	GO:0000070	1/139	mitotic sister chromatid segregation	biological_process	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
EOG8CZDW8	GO:0022416	1/139	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8CZDW8	GO:0005875	1/139	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8CZDW8	GO:0035220	1/139	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8CZDW8	GO:0050775	1/139	positive regulation of dendrite morphogenesis	biological_process	"Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG8CZDW8	GO:0017022	1/139	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8CZDW8	GO:0007019	1/139	microtubule depolymerization	biological_process	"The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194]
EOG8CZDW8	GO:0006200	1/139	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8CZDW8	GO:0031122	1/139	cytoplasmic microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
EOG8CZDW8	GO:0016322	1/139	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG8CZDW8	GO:0030336	1/139	negative regulation of cell migration	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]
EOG8CZDW8	GO:0008582	1/139	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG80S2WC	GO:0006629	148/439	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG80S2WC	GO:0005576	148/439	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG80S2WC	GO:0008970	88/439	phosphatidylcholine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32]
EOG80S2WC	GO:0016787	52/439	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG80S2WC	GO:0052739	12/439	phosphatidylserine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG:R04034]
EOG80S2WC	GO:0052740	12/439	1-acyl-2-lysophosphatidylserine acylhydrolase activity	molecular_function	"Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32]
EOG80S2WC	GO:0004806	11/439	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG80S2WC	GO:0003824	3/439	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG80S2WC	GO:0003676	1/439	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80S2WC	GO:0008270	1/439	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80S2WC	GO:0022008	1/439	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8C5G1W	GO:0006122	23/67	mitochondrial electron transport, ubiquinol to cytochrome c	biological_process	"The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]
EOG8C5G1W	GO:0005750	23/67	mitochondrial respiratory chain complex III	cellular_component	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684]
EOG8C5G1W	GO:0007286	1/67	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG8C5G1W	GO:0008121	1/67	ubiquinol-cytochrome-c reductase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]
EOG8CZDWD	GO:0005622	23/100	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8CZDWD	GO:0007165	22/100	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8CZDWD	GO:0007480	1/100	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8CZDWD	GO:0007370	1/100	ventral furrow formation	biological_process	"Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238]
EOG8CZDWD	GO:0032321	1/100	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8CZDWD	GO:0007266	1/100	Rho protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf]
EOG8CZDWD	GO:0051497	1/100	negative regulation of stress fiber assembly	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]
EOG8CZDWD	GO:0045887	1/100	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8CZDWD	GO:0005100	1/100	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8CZDWN	GO:0016021	26/92	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CZDWN	GO:0045089	1/92	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8CZDWN	GO:0050829	1/92	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG80S2W6	GO:0007015	1/99	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG80S2W6	GO:0006030	1/99	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG80S2W6	GO:0045793	1/99	positive regulation of cell size	biological_process	"Any process that increases cell size." [GOC:go_curators]
EOG80S2W6	GO:0032440	1/99	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG80S2W6	GO:0005576	1/99	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG80S2W6	GO:0008061	1/99	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8CZDWM	GO:0005234	18/66	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8CZDWM	GO:0004970	17/66	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8CZDWM	GO:0016020	15/66	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CZDWM	GO:0016021	3/66	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CZDWM	GO:0034220	1/66	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8CZDWM	GO:0036081	1/66	extracellular ammonia-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
EOG8CZDWM	GO:0071683	1/66	sensory dendrite	cellular_component	"A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron." [GOC:dos, GOC:kmv, GOC:mah]
EOG8CZDWM	GO:0015276	1/66	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8CZDWM	GO:0043235	1/66	receptor complex	cellular_component	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]
EOG8CZDWM	GO:0071229	1/66	cellular response to acid chemical	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:mah, http://en.wikipedia.org/wiki/Acid]
EOG8CZDWM	GO:0050907	1/66	detection of chemical stimulus involved in sensory perception	biological_process	"The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
EOG80S2W1	GO:0016021	18/35	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80S2W1	GO:0055085	18/35	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG80S2W1	GO:0005886	4/35	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80S2W1	GO:0005215	4/35	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8ZSCH6	GO:0005509	22/93	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8ZSCH6	GO:0003779	1/93	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8ZSCH6	GO:0016321	1/93	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8ZSCH6	GO:0004725	1/93	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8XKXQF	GO:0005634	20/50	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XKXQF	GO:0051726	13/50	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8XKXQF	GO:0045448	1/50	mitotic cell cycle, embryonic	biological_process	"The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators]
EOG8XKXQF	GO:0045859	1/50	regulation of protein kinase activity	biological_process	"Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
EOG8XKXQF	GO:0007067	1/50	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8XKXQF	GO:0016538	1/50	cyclin-dependent protein serine/threonine kinase regulator activity	molecular_function	"Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]
EOG8XKXQF	GO:0005515	1/50	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8C5G1B	GO:0031083	1/56	BLOC-1 complex	cellular_component	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]
EOG8C5G1B	GO:0005515	1/56	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8C5G1B	GO:0008057	1/56	eye pigment granule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295]
EOG8QZB1Q	GO:0008270	29/97	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8QZB1Q	GO:0016874	3/97	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8QZB1Q	GO:0030713	1/97	ovarian follicle cell stalk formation	biological_process	"Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8QZB1Q	GO:0007126	1/97	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8QZB1Q	GO:0006351	1/97	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8QZB1Q	GO:0007275	1/97	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8QZB1Q	GO:0022008	1/97	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8QZB1Q	GO:0008278	1/97	cohesin complex	cellular_component	"A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:sp, PMID:9887095]
EOG8QZB1Q	GO:0045498	1/97	sex comb development	biological_process	"The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk]
EOG8QZB1Q	GO:0007062	1/97	sister chromatid cohesion	biological_process	"The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other." [GOC:jh, GOC:mah, ISBN:0815316194]
EOG8QZB1Q	GO:0006342	1/97	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG8QZB1Q	GO:0005634	1/97	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8QZB1Q	GO:0005515	1/97	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QZB1Q	GO:0030708	1/97	germarium-derived female germ-line cyst encapsulation	biological_process	"Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336]
EOG8QZB1Q	GO:0035518	1/97	histone H2A monoubiquitination	biological_process	"The modification of histone H2A by addition of a single ubiquitin group." [PMID:18206970]
EOG8QZB1Q	GO:0005730	1/97	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8QZB1Q	GO:0035102	1/97	PRC1 complex	cellular_component	"A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979]
EOG8RNDS2	GO:0005525	26/112	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8RNDS2	GO:0007264	26/112	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8RNDS2	GO:0008060	23/112	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8RNDS2	GO:0032312	23/112	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8RNDS2	GO:0005622	23/112	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8RNDS2	GO:0008270	23/112	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RNDS2	GO:0016020	8/112	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RNDS2	GO:0006184	8/112	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8RNDS2	GO:0043547	1/112	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8ZSCH8	GO:0008270	38/129	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZSCH8	GO:0048749	1/129	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8ZSCH8	GO:0019100	1/129	male germ-line sex determination	biological_process	"The determination of sex and sexual phenotype in a male organism's germ line." [GOC:mah]
EOG8ZSCH8	GO:0042393	1/129	histone binding	molecular_function	"Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl]
EOG8ZSCH8	GO:0005700	1/129	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8ZSCH8	GO:0022008	1/129	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8ZSCH8	GO:0046872	1/129	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85MQMK	GO:0071011	1/107	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG85MQMK	GO:0071013	1/107	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG85MQMK	GO:0000398	1/107	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG837TXH	GO:0005576	6/76	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG837TXH	GO:0008061	6/76	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG837TXH	GO:0006030	6/76	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG837TXH	GO:0005201	1/76	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG837TXH	GO:0031012	1/76	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG837TXH	GO:0005581	1/76	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8NGK3G	GO:0005215	1/30	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8NGK3G	GO:0055085	1/30	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8NGK3G	GO:0005795	1/30	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG8NGK3G	GO:0008378	1/30	galactosyltransferase activity	molecular_function	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]
EOG8NGK3G	GO:0016020	1/30	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CJXWZ	GO:0016829	1/15	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8CJXWZ	GO:0016021	1/15	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CJXWZ	GO:0022857	1/15	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8CJXWZ	GO:0003924	1/15	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8CJXWZ	GO:0005525	1/15	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8M3CPT	GO:0016772	24/72	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8M3CPT	GO:0016301	1/72	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8616K2	GO:0004871	8/63	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8616K2	GO:0003677	6/63	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8616K2	GO:0005634	6/63	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8616K2	GO:0006355	6/63	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8616K2	GO:0006351	6/63	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8616K2	GO:0003989	2/63	acetyl-CoA carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2]
EOG8K3PBS	GO:0016740	5/476	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8K3PBS	GO:0016021	5/476	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8K3PBS	GO:0003676	1/476	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K3PBS	GO:0008270	1/476	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NGK3S	GO:0003964	2/58	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8NGK3S	GO:0003723	1/58	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8XKXMR	GO:0008017	1/89	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8XKXMR	GO:0007098	1/89	centrosome cycle	biological_process	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]
EOG8XKXMR	GO:0007422	1/89	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8XKXMR	GO:0007067	1/89	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8XKXMR	GO:0007279	1/89	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8XKXMR	GO:0007494	1/89	midgut development	biological_process	"The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
EOG8XKXMR	GO:0005813	1/89	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8XKXMR	GO:0055059	1/89	asymmetric neuroblast division	biological_process	"The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
EOG8XKXMR	GO:0005929	1/89	cilium	cellular_component	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:kmv, GOC:vw, ISBN:0198547684]
EOG8XKXMR	GO:0008356	1/89	asymmetric cell division	biological_process	"The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
EOG8XKXMR	GO:0005515	1/89	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8XKXMR	GO:0000242	1/89	pericentriolar material	cellular_component	"A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]
EOG8XKXMR	GO:0005875	1/89	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8XKXMR	GO:0000922	1/89	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8XKXMR	GO:0007099	1/89	centriole replication	biological_process	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194]
EOG8XKXMR	GO:0008594	1/89	photoreceptor cell morphogenesis	biological_process	"The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
EOG8XKXMR	GO:0051297	1/89	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8XKXMR	GO:0016321	1/89	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8XKXMR	GO:0007017	1/89	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8XKXMR	GO:0005814	1/89	centriole	cellular_component	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
EOG8XKXMR	GO:0040016	1/89	embryonic cleavage	biological_process	"The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300]
EOG8XKXMR	GO:0030997	1/89	regulation of centriole-centriole cohesion	biological_process	"Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker." [PMID:11076968]
EOG8XKXMR	GO:0007052	1/89	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8XKXMR	GO:0007417	1/89	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8M3CPK	GO:0003678	9/67	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8M3CPK	GO:0000723	9/67	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8M3CPK	GO:0006281	9/67	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8M3CPK	GO:0004386	3/67	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8M3CPK	GO:0005524	3/67	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8M3CPK	GO:0003676	1/67	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M3CPK	GO:0006511	1/67	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG84BDH4	GO:0005737	4/100	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84BDH4	GO:0007620	4/100	copulation	biological_process	"The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544]
EOG84BDH4	GO:0007610	3/100	behavior	biological_process	"The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
EOG84BDH4	GO:0046426	1/100	negative regulation of JAK-STAT cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG84BDH4	GO:0045893	1/100	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG84BDH4	GO:0045571	1/100	negative regulation of imaginal disc growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators]
EOG84BDH4	GO:0005515	1/100	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG84BDH4	GO:0000932	1/100	cytoplasmic mRNA processing body	cellular_component	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603]
EOG84BDH4	GO:0060179	1/100	male mating behavior	biological_process	"The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb]
EOG84BDH5	GO:0004407	18/102	histone deacetylase activity	molecular_function	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.98, PMID:9893272]
EOG84BDH5	GO:0000118	18/102	histone deacetylase complex	cellular_component	"A protein complex that possesses histone deacetylase activity." [GOC:mah]
EOG84BDH5	GO:0016787	6/102	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG84BDH5	GO:0006355	1/102	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG84BDH5	GO:0005634	1/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84BDH5	GO:0016575	1/102	histone deacetylation	biological_process	"The modification of histones by removal of acetyl groups." [GOC:ai]
EOG84BDH5	GO:0005737	1/102	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XKXMZ	GO:0016021	23/55	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XKXMZ	GO:0005328	23/55	neurotransmitter:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
EOG8XKXMZ	GO:0002009	1/55	morphogenesis of an epithelium	biological_process	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
EOG8M3CPF	GO:0003924	27/110	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8M3CPF	GO:0005525	27/110	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8M3CPF	GO:0090148	1/110	membrane fission	biological_process	"A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8M3CPF	GO:0008355	1/110	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8M3CPF	GO:0034334	1/110	adherens junction maintenance	biological_process	"The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah]
EOG8M3CPF	GO:0030866	1/110	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8M3CPF	GO:0007349	1/110	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG8M3CPF	GO:0000281	1/110	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8M3CPF	GO:0045202	1/110	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8M3CPF	GO:0008017	1/110	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8M3CPF	GO:0045747	1/110	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8M3CPF	GO:0007298	1/110	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8M3CPF	GO:0007435	1/110	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8M3CPF	GO:0005737	1/110	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8M3CPF	GO:0048499	1/110	synaptic vesicle membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle." [GOC:dph, GOC:jl, GOC:mah, PMID:10620806]
EOG8M3CPF	GO:0046843	1/110	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8M3CPF	GO:0048489	1/110	synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr]
EOG8M3CPF	GO:0006898	1/110	receptor-mediated endocytosis	biological_process	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
EOG8M3CPF	GO:0007613	1/110	memory	biological_process	"The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089]
EOG8M3CPF	GO:0032970	1/110	regulation of actin filament-based process	biological_process	"Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah]
EOG8M3CPF	GO:0009408	1/110	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8M3CPF	GO:0006897	1/110	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8M3CPF	GO:0030536	1/110	larval feeding behavior	biological_process	"Feeding behavior in a larval (immature) organism." [GOC:mah]
EOG8M3CPF	GO:0007612	1/110	learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544]
EOG8M3CPF	GO:0016185	1/110	synaptic vesicle budding from presynaptic membrane	biological_process	"Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." [GOC:curators, PMID:10099709]
EOG8M3CPF	GO:0046667	1/110	compound eye retinal cell programmed cell death	biological_process	"Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672]
EOG8M3CPF	GO:0007427	1/110	epithelial cell migration, open tracheal system	biological_process	"The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8M3CPF	GO:0050803	1/110	regulation of synapse structure or activity	biological_process	"Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]
EOG8M3CPF	GO:0048488	1/110	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8M3CPF	GO:0006184	1/110	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8M3CPF	GO:0005886	1/110	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8M3CPF	GO:0007637	1/110	proboscis extension reflex	biological_process	"The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jid]
EOG8M3CPF	GO:0001661	1/110	conditioned taste aversion	biological_process	"A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659]
EOG8M3CPF	GO:0032956	1/110	regulation of actin cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]
EOG8M3CPF	GO:0040008	1/110	regulation of growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]
EOG8M3CPF	GO:0003779	1/110	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8M3CPF	GO:0007614	1/110	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8M3CPF	GO:0072583	1/110	clathrin-mediated endocytosis	biological_process	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]
EOG8M3CPF	GO:0001738	1/110	morphogenesis of a polarized epithelium	biological_process	"The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]
EOG8M3CPF	GO:0070864	1/110	sperm individualization complex	cellular_component	"A macromolecular complex that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst." [GOC:sart, PMID:10588662, PMID:9550716]
EOG8M3CPF	GO:0035152	1/110	regulation of tube architecture, open tracheal system	biological_process	"Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584]
EOG8M3CPF	GO:0007291	1/110	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8M3CPF	GO:0007424	1/110	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8M3CPF	GO:0030198	1/110	extracellular matrix organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]
EOG8M3CPF	GO:0005874	1/110	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8M3CPF	GO:0048172	1/110	regulation of short-term neuronal synaptic plasticity	biological_process	"A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290]
EOG87M4BT	GO:0003677	24/98	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG87M4BT	GO:0008138	22/98	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG87M4BT	GO:0004725	22/98	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG87M4BT	GO:0006470	1/98	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG87M4BT	GO:0007409	1/98	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG87M4BT	GO:0040023	1/98	establishment of nucleus localization	biological_process	"The directed movement of the nucleus to a specific location within a cell." [GOC:ai]
EOG87M4BT	GO:0030837	1/98	negative regulation of actin filament polymerization	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]
EOG87M4BT	GO:0008064	1/98	regulation of actin polymerization or depolymerization	biological_process	"Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]
EOG87M4BT	GO:0003779	1/98	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG87M4BT	GO:0050770	1/98	regulation of axonogenesis	biological_process	"Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]
EOG87M4BT	GO:0030833	1/98	regulation of actin filament polymerization	biological_process	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG87M4BT	GO:0005737	1/98	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87M4BT	GO:0048749	1/98	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG87M4BT	GO:0045177	1/98	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG87M4BT	GO:0005856	1/98	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG87M4BT	GO:0000278	1/98	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG87M4BT	GO:0004721	1/98	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG87M4BT	GO:0000902	1/98	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG87M4BT	GO:0016319	1/98	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG87M4BT	GO:0010591	1/98	regulation of lamellipodium assembly	biological_process	"Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG8M3CPC	GO:0008270	5/37	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8M3CPC	GO:0006511	4/37	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8M3CPC	GO:0008234	2/37	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG81RS7S	GO:0005524	51/178	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG81RS7S	GO:0016021	47/178	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81RS7S	GO:0004672	47/178	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG81RS7S	GO:0035556	46/178	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG81RS7S	GO:0004383	42/178	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG81RS7S	GO:0016849	4/178	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG81RS7S	GO:0009190	4/178	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG81RS7S	GO:0016772	2/178	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG81RS7S	GO:0004709	1/178	MAP kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
EOG81RS7S	GO:0004715	1/178	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8WWTZC	GO:0000166	6/79	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8WWTZC	GO:0003676	5/79	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WWTZC	GO:0046872	3/79	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WWTZC	GO:0003677	1/79	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81NX1D	GO:0003676	1/92	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG81NX1D	GO:0046872	1/92	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG841SSW	GO:0004550	8/37	nucleoside diphosphate kinase activity	molecular_function	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]
EOG841SSW	GO:0006241	8/37	CTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]
EOG841SSW	GO:0006228	8/37	UTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732]
EOG841SSW	GO:0006183	8/37	GTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG841SSW	GO:0005524	8/37	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SN431	GO:0004553	2/7	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8SN431	GO:0005975	2/7	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8SN431	GO:0005351	1/7	sugar:proton symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]
EOG8SN431	GO:0016020	1/7	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8SN431	GO:0008982	1/7	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	molecular_function	"Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-]
EOG8SN431	GO:0009401	1/7	phosphoenolpyruvate-dependent sugar phosphotransferase system	biological_process	"The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html]
EOG841SSS	GO:0016788	1/277	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG80306Z	GO:0005215	3/8	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG80306Z	GO:0016021	3/8	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80306Z	GO:0055085	3/8	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG80GG6B	GO:0043565	22/80	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG80GG6B	GO:0090502	1/80	RNA phosphodiester bond hydrolysis, endonucleolytic	biological_process	"The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
EOG80GG6B	GO:0007630	1/80	jump response	biological_process	"The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jid, ISBN:0198606907]
EOG80GG6B	GO:0016246	1/80	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG80GG6B	GO:0005737	1/80	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG80GG6B	GO:0004521	1/80	endoribonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG80GG6B	GO:0050821	1/80	protein stabilization	biological_process	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]
EOG81NX1Q	GO:0005234	10/69	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG81NX1Q	GO:0004970	10/69	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG81NX1Q	GO:0016021	9/69	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81NX1Q	GO:0045211	5/69	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG81NX1Q	GO:0030054	5/69	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG81NX1Q	GO:0016020	1/69	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8WWTZX	GO:0005044	1/84	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8WWTZX	GO:0035556	1/84	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8WWTZX	GO:0035073	1/84	pupariation	biological_process	"The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
EOG8WWTZX	GO:0004721	1/84	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8WWTZX	GO:0016020	1/84	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8WWTZX	GO:0035075	1/84	response to ecdysone	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf]
EOG88D38F	GO:0006886	29/95	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG88D38F	GO:0005801	29/95	cis-Golgi network	cellular_component	"The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]
EOG88D38F	GO:0016020	26/95	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG88D38F	GO:0000139	3/95	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG88D38F	GO:0017119	3/95	Golgi transport complex	cellular_component	"A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p)." [GOC:krc, PMID:9792665]
EOG88D38F	GO:0006891	3/95	intra-Golgi vesicle-mediated transport	biological_process	"The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]
EOG88D38F	GO:0006888	3/95	ER to Golgi vesicle-mediated transport	biological_process	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]
EOG88D38F	GO:0008565	3/95	protein transporter activity	molecular_function	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
EOG88D38F	GO:0022008	1/95	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG88D38F	GO:0007112	1/95	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG88D38F	GO:0033227	1/95	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG80GG6J	GO:0042048	1/84	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG841SSB	GO:0031418	27/127	L-ascorbic acid binding	molecular_function	"Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]
EOG841SSB	GO:0005506	27/127	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG841SSB	GO:0016706	26/127	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG841SSB	GO:0005634	10/127	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG841SSB	GO:0006355	9/127	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG841SSB	GO:0046872	4/127	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG841SSB	GO:0031543	1/127	peptidyl-proline dioxygenase activity	molecular_function	"Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]
EOG841SSB	GO:0030307	1/127	positive regulation of cell growth	biological_process	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG841SSB	GO:0019511	1/127	peptidyl-proline hydroxylation	biological_process	"The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline." [GOC:mah]
EOG841SSB	GO:0060439	1/127	trachea morphogenesis	biological_process	"The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG841SSB	GO:0001666	1/127	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG841SSB	GO:0000124	1/127	SAGA complex	cellular_component	"A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012]
EOG841SSB	GO:0005654	1/127	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG841SSB	GO:0008104	1/127	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG841SSB	GO:0007430	1/127	terminal branching, open tracheal system	biological_process	"Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG841SSB	GO:0071456	1/127	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG841SSB	GO:0043970	1/127	histone H3-K9 acetylation	biological_process	"The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl]
EOG841SSB	GO:0006974	1/127	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG841SSB	GO:0006611	1/127	protein export from nucleus	biological_process	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]
EOG80GG67	GO:0006950	2/58	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG80GG67	GO:0046872	1/58	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80GG67	GO:0020037	1/58	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG80GG63	GO:0005254	42/136	chloride channel activity	molecular_function	"Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG80GG63	GO:0034707	42/136	chloride channel complex	cellular_component	"An ion channel complex through which chloride ions pass." [GOC:mah]
EOG80GG63	GO:1902476	2/136	chloride transmembrane transport	biological_process	"The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw]
EOG80GG63	GO:0005886	2/136	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80GG63	GO:0016319	1/136	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG80GG63	GO:0016021	1/136	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80GG63	GO:0006909	1/136	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG80GG63	GO:0002121	1/136	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8DJN9F	GO:0003677	26/102	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DJN9F	GO:0006355	24/102	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8DJN9F	GO:0005634	20/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8DJN9F	GO:0046872	9/102	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DJN9F	GO:0016705	3/102	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8DJN9F	GO:0005506	3/102	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8DJN9F	GO:0020037	3/102	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8DJN9F	GO:0004497	2/102	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8DJN9F	GO:0050821	1/102	protein stabilization	biological_process	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]
EOG8DJN9F	GO:0008587	1/102	imaginal disc-derived wing margin morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG8DJN9F	GO:0006909	1/102	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8DJN9F	GO:0005515	1/102	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8DJN9F	GO:0031936	1/102	negative regulation of chromatin silencing	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah]
EOG8DJN9F	GO:0042059	1/102	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8DJN9F	GO:0007480	1/102	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8DJN9F	GO:0008586	1/102	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG8DJN9F	GO:0035060	1/102	brahma complex	cellular_component	"A SWI/SNF-type complex that contains the ATPase product of the Drosophila brahma gene, or an ortholog thereof." [GOC:bf, PMID:10809665, PMID:12482982]
EOG8DJN9F	GO:0005700	1/102	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8DJN9F	GO:0045893	1/102	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8QNQBR	GO:0016773	6/53	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8QNQBR	GO:0016798	4/53	hydrolase activity, acting on glycosyl bonds	molecular_function	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]
EOG8QNQBR	GO:0016616	2/53	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8QNQBR	GO:0006094	1/53	gluconeogenesis	biological_process	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]
EOG8QNQBR	GO:0005524	1/53	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QNQBR	GO:0005975	1/53	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8QNQBR	GO:0004736	1/53	pyruvate carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847]
EOG8QNQBR	GO:0004075	1/53	biotin carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]
EOG8QNQBR	GO:0044262	1/53	cellular carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
EOG8QNQBP	GO:0005581	1/64	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG841SS0	GO:0016021	1/76	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG841SS0	GO:0004721	1/76	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG81NX16	GO:0006511	5/12	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG81NX16	GO:0004843	4/12	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG81NX14	GO:0042060	1/93	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG81NX15	GO:0016020	25/91	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG81NX15	GO:0005215	24/91	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG81NX15	GO:0071421	1/91	manganese ion transmembrane transport	biological_process	"A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG81NX15	GO:0006032	1/91	chitin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG81NX15	GO:0005381	1/91	iron ion transmembrane transporter activity	molecular_function	"Catalysis of the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai]
EOG81NX15	GO:0015677	1/91	copper ion import	biological_process	"The directed movement of copper ions into a cell or organelle." [GOC:ai]
EOG81NX15	GO:0055070	1/91	copper ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
EOG81NX15	GO:0055076	1/91	transition metal ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:jid, GOC:mah, ISBN:0198506732]
EOG81NX15	GO:0005886	1/91	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG81NX15	GO:0005384	1/91	manganese ion transmembrane transporter activity	molecular_function	"Catalysis of the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:dgf]
EOG81NX15	GO:0005375	1/91	copper ion transmembrane transporter activity	molecular_function	"Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai]
EOG81NX15	GO:0005887	1/91	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81NX15	GO:0050916	1/91	sensory perception of sweet taste	biological_process	"The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG81NX15	GO:0015293	1/91	symporter activity	molecular_function	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
EOG81NX15	GO:0034761	1/91	positive regulation of iron ion transmembrane transport	biological_process	"Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG81NX15	GO:0034755	1/91	iron ion transmembrane transport	biological_process	"A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG81NX15	GO:0033212	1/91	iron assimilation	biological_process	"A process in which iron is solubilized and transported into a cell." [GOC:cjm, GOC:mah]
EOG81NX15	GO:0060586	1/91	multicellular organismal iron ion homeostasis	biological_process	"Any process involved in the maintenance of the distribution of iron stores within tissues and organs of a multicellular organism." [GOC:dph, GOC:hjd, GOC:tb]
EOG81NX15	GO:0005768	1/91	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG81NX15	GO:0004568	1/91	chitinase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
EOG81NX15	GO:0005975	1/91	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG81NX15	GO:0070838	1/91	divalent metal ion transport	biological_process	"The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG81NX15	GO:0046718	1/91	viral entry into host cell	biological_process	"The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm." [GOC:jl]
EOG81NX15	GO:0000041	1/91	transition metal ion transport	biological_process	"The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]
EOG8DJN9T	GO:0005272	31/100	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8DJN9T	GO:0016021	27/100	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DJN9T	GO:0016020	4/100	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8DJN9T	GO:0008049	1/100	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8DJN9T	GO:0019236	1/100	response to pheromone	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl]
EOG8DJN9T	GO:0002121	1/100	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8DJN9V	GO:0016020	62/202	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8DJN9V	GO:0005524	60/202	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8DJN9V	GO:0016887	58/202	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8DJN9V	GO:0006810	29/202	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8DJN9V	GO:0016021	4/202	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DJN9V	GO:0031409	3/202	pigment binding	molecular_function	"Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah]
EOG8DJN9V	GO:0006727	2/202	ommochrome biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
EOG8DJN9V	GO:0006856	2/202	eye pigment precursor transport	biological_process	"The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8DJN9V	GO:0048072	1/202	compound eye pigmentation	biological_process	"Establishment of a pattern of pigment in the compound eye." [GOC:jid]
EOG8DJN9V	GO:0031410	1/202	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG8DJN9V	GO:0042401	1/202	cellular biogenic amine biosynthetic process	biological_process	"The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]
EOG8DJN9V	GO:0004888	1/202	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8DJN9V	GO:0008049	1/202	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8DJN9V	GO:0007165	1/202	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8DJN9V	GO:0007613	1/202	memory	biological_process	"The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089]
EOG8DJN9V	GO:0042441	1/202	eye pigment metabolic process	biological_process	"The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
EOG8DJN9V	GO:0070731	1/202	cGMP transport	biological_process	"The directed movement of cyclic GMP (cGMP), into, out of or within a cell." [GOC:mah, ISBN:0198506732]
EOG8DJN9V	GO:0015416	1/202	organic phosphonate transmembrane-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:3.6.3.28]
EOG8DJN9V	GO:0042332	1/202	gravitaxis	biological_process	"The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
EOG8DJN9V	GO:0015417	1/202	polyamine-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)." [EC:3.6.3.31]
EOG81VNJG	GO:0035556	6/50	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG81VNJG	GO:0046872	6/50	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG893624	GO:0008023	3/22	transcription elongation factor complex	cellular_component	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]
EOG893624	GO:0006368	3/22	transcription elongation from RNA polymerase II promoter	biological_process	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
EOG84XMX9	GO:0046872	24/89	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84XMX9	GO:0070006	22/89	metalloaminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG84XMX9	GO:0070084	22/89	protein initiator methionine removal	biological_process	"The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein." [GOC:imk, GOC:mah]
EOG84XMX9	GO:0022626	22/89	cytosolic ribosome	cellular_component	"A ribosome located in the cytosol." [GOC:mtg_sensu]
EOG84XMX9	GO:0008235	2/89	metalloexopeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]
EOG84XMX9	GO:0004177	2/89	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG8616KS	GO:0030170	25/130	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8616KS	GO:0003824	25/130	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8616KS	GO:0030151	25/130	molybdenum ion binding	molecular_function	"Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai]
EOG83N9VW	GO:0005634	95/339	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83N9VW	GO:0003700	95/339	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG83N9VW	GO:0043565	89/339	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG83N9VW	GO:0019101	1/339	female somatic sex determination	biological_process	"The determination of sex and sexual phenotypes in a female organism's soma." [GOC:mah]
EOG83N9VW	GO:0000398	1/339	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG83N9VW	GO:0003677	1/339	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG83N9VW	GO:0007548	1/339	sex differentiation	biological_process	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]
EOG83N9VW	GO:0045497	1/339	female analia development	biological_process	"The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
EOG83N9VW	GO:0001078	1/339	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
EOG83N9VW	GO:0008049	1/339	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG83N9VW	GO:0045892	1/339	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0046661	1/339	male sex differentiation	biological_process	"The establishment of the sex of a male organism by physical differentiation." [GOC:bf]
EOG83N9VW	GO:0048086	1/339	negative regulation of developmental pigmentation	biological_process	"Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
EOG83N9VW	GO:0045433	1/339	male courtship behavior, veined wing generated song production	biological_process	"The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
EOG83N9VW	GO:0018993	1/339	somatic sex determination	biological_process	"The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems]
EOG83N9VW	GO:0006355	1/339	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0042803	1/339	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG83N9VW	GO:0045893	1/339	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0048071	1/339	sex-specific pigmentation	biological_process	"Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jid]
EOG83N9VW	GO:0045496	1/339	male analia development	biological_process	"The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
EOG83N9VW	GO:0007619	1/339	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG83N9VW	GO:0007283	1/339	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG83N9VW	GO:0007417	1/339	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG83N9VW	GO:0016199	1/339	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG83N9VW	GO:0035215	1/339	genital disc development	biological_process	"Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318]
EOG83N9VW	GO:0045944	1/339	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0046872	1/339	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83N9VW	GO:0003729	1/339	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG83N9VW	GO:0045498	1/339	sex comb development	biological_process	"The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk]
EOG83N9VW	GO:0005515	1/339	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG83N9VW	GO:0000122	1/339	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0007483	1/339	genital disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238]
EOG83N9VW	GO:0001077	1/339	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG83N9VW	GO:0007530	1/339	sex determination	biological_process	"Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732]
EOG83N9VW	GO:0007486	1/339	imaginal disc-derived female genitalia development	biological_process	"The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
EOG83N9VW	GO:0006357	1/339	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0019102	1/339	male somatic sex determination	biological_process	"The determination of sex and sexual phenotypes in a male organism's soma." [GOC:mah]
EOG83N9VW	GO:0007485	1/339	imaginal disc-derived male genitalia development	biological_process	"The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
EOG83N9VW	GO:0035263	1/339	genital disc sexually dimorphic development	biological_process	"The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781]
EOG83N9VW	GO:0046660	1/339	female sex differentiation	biological_process	"The establishment of the sex of a female organism by physical differentiation." [GOC:bf]
EOG83N9VW	GO:0045570	1/339	regulation of imaginal disc growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators]
EOG8NGK30	GO:0016491	28/91	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8NGK30	GO:0050221	1/91	prostaglandin-E2 9-reductase activity	molecular_function	"Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH." [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN]
EOG88GZJ7	GO:0003676	1/365	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88GZJ7	GO:0003677	1/365	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG88GZJ7	GO:0003899	1/365	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG88GZJ7	GO:0006351	1/365	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG84BDHT	GO:0016791	4/14	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG8NGK38	GO:0003676	1/15	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NGK38	GO:0004672	1/15	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8NGK38	GO:0005524	1/15	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG83N9VG	GO:0019441	13/94	tryptophan catabolic process to kynurenine	biological_process	"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]
EOG83N9VG	GO:0004061	13/94	arylformamidase activity	molecular_function	"Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9]
EOG83N9VG	GO:0016787	10/94	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG808QPN	GO:0005524	15/77	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG808QPN	GO:0006298	15/77	mismatch repair	biological_process	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
EOG808QPN	GO:0030983	15/77	mismatched DNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]
EOG808QPM	GO:0016491	54/152	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG808QPM	GO:0050112	1/152	inositol 2-dehydrogenase activity	molecular_function	"Catalysis of the reaction: myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + H(+) + NADH." [EC:1.1.1.18, RHEA:16952]
EOG8TTK15	GO:0003677	28/194	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TTK15	GO:0004518	28/194	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8TTK15	GO:0005634	7/194	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TTK15	GO:0016568	7/194	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG8TTK12	GO:0035152	1/63	regulation of tube architecture, open tracheal system	biological_process	"Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584]
EOG8TTK12	GO:0008362	1/63	chitin-based embryonic cuticle biosynthetic process	biological_process	"Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232]
EOG8TTK12	GO:0006031	1/63	chitin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8TTK12	GO:0035158	1/63	regulation of tube diameter, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584]
EOG8TTK12	GO:0007424	1/63	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG82JR5X	GO:0003677	15/78	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG82JR5X	GO:0003676	1/78	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82JR5X	GO:0000166	1/78	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8K3PC5	GO:0015074	10/59	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8K3PC5	GO:0003676	9/59	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K3PC5	GO:0004190	5/59	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8K3PC5	GO:0003964	5/59	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8K3PC5	GO:0003723	5/59	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8BVV8M	GO:0003677	3/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8BVV8M	GO:0003723	1/5	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8BVV8M	GO:0003964	1/5	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8BVV8P	GO:0003824	17/86	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8BVV8P	GO:0016740	4/86	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8BVV8P	GO:0016768	4/86	spermine synthase activity	molecular_function	"Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine." [EC:2.5.1.22]
EOG8BVV8P	GO:0004766	1/86	spermidine synthase activity	molecular_function	"Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine." [EC:2.5.1.16]
EOG82JR5H	GO:0016020	86/342	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82JR5H	GO:0008236	85/342	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG82JR5H	GO:0006508	7/342	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG82JR5H	GO:0008239	2/342	dipeptidyl-peptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]
EOG82JR5H	GO:0016491	1/342	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG82JR5H	GO:0005576	1/342	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG808QPW	GO:0003677	4/11	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG808QPW	GO:0005634	4/11	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82JR5C	GO:0015385	25/109	sodium:proton antiporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-]
EOG82JR5C	GO:0006885	25/109	regulation of pH	biological_process	"Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG82JR5C	GO:0016021	25/109	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82JR5C	GO:0006873	1/109	cellular ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of ions at the level of a cell." [GOC:mah]
EOG8H48JR	GO:0006355	6/20	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG815JT9	GO:0001104	29/106	RNA polymerase II transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG815JT9	GO:0016592	29/106	mediator complex	cellular_component	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
EOG815JT9	GO:0006366	2/106	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG815JT9	GO:0006367	1/106	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG815JT9	GO:0005515	1/106	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8H48JF	GO:0016987	1/14	sigma factor activity	molecular_function	"A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes." [GOC:krc, GOC:txnOH]
EOG8H48JF	GO:0003677	1/14	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8H48JF	GO:0006352	1/14	DNA-templated transcription, initiation	biological_process	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]
EOG8H48JF	GO:0003700	1/14	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8BK7MJ	GO:0005852	26/88	eukaryotic translation initiation factor 3 complex	cellular_component	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]
EOG8BK7MJ	GO:0003743	26/88	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8BK7MJ	GO:0006446	22/88	regulation of translational initiation	biological_process	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG8BK7MJ	GO:0001731	22/88	formation of translation preinitiation complex	biological_process	"The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd]
EOG8BK7MJ	GO:0016282	22/88	eukaryotic 43S preinitiation complex	cellular_component	"A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049]
EOG8BK7MJ	GO:0033290	22/88	eukaryotic 48S preinitiation complex	cellular_component	"A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049]
EOG8BK7MJ	GO:0022008	1/88	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8BK7MJ	GO:0006413	1/88	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG8BK7MJ	GO:0005515	1/88	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8H48JJ	GO:0045177	1/82	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8H48JJ	GO:0008362	1/82	chitin-based embryonic cuticle biosynthetic process	biological_process	"Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232]
EOG8H48JJ	GO:0007424	1/82	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8H48JJ	GO:0007475	1/82	apposition of dorsal and ventral imaginal disc-derived wing surfaces	biological_process	"The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu]
EOG8H48JJ	GO:0040005	1/82	chitin-based cuticle attachment to epithelium	biological_process	"Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8NGK2N	GO:0004252	12/110	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8NGK2N	GO:0020037	1/110	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8NGK2N	GO:0016705	1/110	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8NGK2N	GO:0005506	1/110	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8VMHW5	GO:0008270	14/87	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VMHW5	GO:0016491	12/87	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8VMHW5	GO:0003960	2/87	NADPH:quinone reductase activity	molecular_function	"Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5]
EOG8VMHW5	GO:0003824	1/87	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8VMHW5	GO:0016747	1/87	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8H48J1	GO:0008270	17/89	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8H48J1	GO:0022008	1/89	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8H48J1	GO:0043161	1/89	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG8H48J1	GO:0098586	1/89	cellular response to virus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:dos]
EOG8H48J1	GO:0006511	1/89	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8KH58M	GO:0007165	21/90	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8KH58M	GO:0048749	1/90	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8KH58M	GO:0033227	1/90	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8KH58M	GO:0040015	1/90	negative regulation of multicellular organism growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG8KH58M	GO:0005912	1/90	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8KH58B	GO:0000922	25/89	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8KH58B	GO:0000226	24/89	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8KH58B	GO:0005815	24/89	microtubule organizing center	cellular_component	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416]
EOG8KH58B	GO:0007020	1/89	microtubule nucleation	biological_process	"The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712]
EOG8KH58B	GO:0005874	1/89	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8KH58B	GO:0051298	1/89	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8KH58B	GO:0008274	1/89	gamma-tubulin ring complex	cellular_component	"A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule." [GOC:clt, PMID:12134075]
EOG8KH58B	GO:0051297	1/89	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8KH58B	GO:0045450	1/89	bicoid mRNA localization	biological_process	"Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators]
EOG8KH58B	GO:0007112	1/89	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG8KH58B	GO:0007067	1/89	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8KH58B	GO:0007052	1/89	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8KH58B	GO:0005200	1/89	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8KH58B	GO:0007058	1/89	spindle assembly involved in female meiosis II	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah]
EOG8KH58C	GO:0046872	10/75	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8KH58C	GO:0003676	10/75	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HTC74	GO:0003964	161/557	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8HTC74	GO:0003723	161/557	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8HTC74	GO:0008270	5/557	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8HTC74	GO:0035556	1/557	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8HTC74	GO:0016787	1/557	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8HTC74	GO:0000166	1/557	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8HTC74	GO:0004519	1/557	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8HTC77	GO:0003676	1/99	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HTC70	GO:0016021	10/64	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8T1M35	GO:0005783	31/91	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8T1M35	GO:0005811	1/91	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8T1M35	GO:0045169	1/91	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG8GB9QV	GO:0006809	1/2	nitric oxide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai]
EOG8GB9QV	GO:0004517	1/2	nitric-oxide synthase activity	molecular_function	"Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39]
EOG8GB9QV	GO:0004424	1/2	imidazoleglycerol-phosphate dehydratase activity	molecular_function	"Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O." [EC:4.2.1.19, RHEA:11043]
EOG8GB9QV	GO:0004635	1/2	phosphoribosyl-AMP cyclohydrolase activity	molecular_function	"Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide." [EC:3.5.4.19, RHEA:20052]
EOG8GB9QV	GO:0030170	1/2	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8GB9QV	GO:0016740	1/2	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8GB9QV	GO:0004636	1/2	phosphoribosyl-ATP diphosphatase activity	molecular_function	"Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+)." [EC:3.6.1.31, RHEA:22831]
EOG8GB9QV	GO:0000105	1/2	histidine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]
EOG8D55D4	GO:0016192	20/93	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8D55D4	GO:0016020	19/93	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8D55D4	GO:0006886	14/93	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8D55D4	GO:0007317	1/93	regulation of pole plasm oskar mRNA localization	biological_process	"Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb]
EOG8D55D4	GO:0007349	1/93	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG8D55D4	GO:0006906	1/93	vesicle fusion	biological_process	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]
EOG8D55D4	GO:0007274	1/93	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8D55D4	GO:0000281	1/93	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8D55D4	GO:0005515	1/93	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8D55D4	GO:0000149	1/93	SNARE binding	molecular_function	"Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]
EOG8D55D4	GO:0016021	1/93	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D55D4	GO:0007482	1/93	haltere development	biological_process	"The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net]
EOG8D55D4	GO:0016081	1/93	synaptic vesicle docking	biological_process	"The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342]
EOG8D55D4	GO:0031201	1/93	SNARE complex	cellular_component	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]
EOG8D55D4	GO:0005886	1/93	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8D55D4	GO:0005484	1/93	SNAP receptor activity	molecular_function	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
EOG8D55D4	GO:0031629	1/93	synaptic vesicle fusion to presynaptic membrane	biological_process	"Fusion of the membrane of a synaptic vesicle with its target presynaptic membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [ISBN:0071120009]
EOG8D55D4	GO:0043195	1/93	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG8D55D4	GO:0008021	1/93	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8D55D4	GO:0007269	1/93	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8RZ1G4	GO:0005549	13/23	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8RZ1G4	GO:0005576	1/23	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8RZ1G4	GO:0007606	1/23	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG81RS92	GO:0007472	1/85	wing disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG81RS92	GO:0005886	1/85	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG81RS92	GO:0005798	1/85	Golgi-associated vesicle	cellular_component	"Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]
EOG81RS92	GO:0005795	1/85	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG81RS92	GO:0005783	1/85	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG81RS92	GO:0005794	1/85	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG81RS92	GO:0016333	1/85	morphogenesis of follicular epithelium	biological_process	"The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl]
EOG81RS92	GO:0007030	1/85	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8RZ1G2	GO:0016021	1/87	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GJ23K	GO:0007165	22/117	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8GJ23K	GO:0017112	1/117	Rab guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8GJ23K	GO:0005085	1/117	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8GJ23K	GO:0005096	1/117	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8GJ23K	GO:0007298	1/117	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8GJ23K	GO:0006897	1/117	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8GJ23K	GO:0032483	1/117	regulation of Rab protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]
EOG8GJ23K	GO:0017016	1/117	Ras GTPase binding	molecular_function	"Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG8GJ23K	GO:0032313	1/117	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8GJ23K	GO:0043087	1/117	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8GJ23K	GO:0030971	1/117	receptor tyrosine kinase binding	molecular_function	"Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity." [GOC:mah]
EOG8GJ23K	GO:0007275	1/117	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8GJ23K	GO:0019901	1/117	protein kinase binding	molecular_function	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]
EOG8GJ23K	GO:0005938	1/117	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8GJ23K	GO:0030139	1/117	endocytic vesicle	cellular_component	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]
EOG8323F6	GO:0016021	3/10	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8323F6	GO:0004930	3/10	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8V9X72	GO:0008270	41/538	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V9X72	GO:0003676	38/538	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V9X72	GO:0003964	3/538	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8V9X72	GO:0003723	3/538	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8V9X72	GO:0006811	1/538	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8V9X72	GO:0005921	1/538	gap junction	cellular_component	"A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181]
EOG808QP5	GO:0005215	34/99	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG808QP5	GO:0055085	34/99	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG808QP5	GO:0016020	31/99	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG808QP5	GO:0016021	3/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG808QP5	GO:0005634	1/99	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG808QP5	GO:0008270	1/99	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG808QP5	GO:0003676	1/99	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V9X6X	GO:0046872	2/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8V9X6X	GO:0009055	2/4	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8V9X6X	GO:0050660	1/4	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8V9X6X	GO:0016491	1/4	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8V9X6X	GO:0051537	1/4	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8V9X6X	GO:0051536	1/4	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8V9X6X	GO:0008762	1/4	UDP-N-acetylmuramate dehydrogenase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158]
EOG88GZH5	GO:0016021	33/129	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88GZH5	GO:0004930	32/129	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG88GZH5	GO:0005886	28/129	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG88GZH5	GO:0008343	1/129	adult feeding behavior	biological_process	"Feeding behavior in a fully developed and mature organism." [GOC:mah]
EOG88GZH5	GO:0003676	1/129	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88GZH5	GO:0030425	1/129	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG88GZH5	GO:0005887	1/129	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88GZH5	GO:0007200	1/129	phospholipase C-activating G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
EOG88GZH5	GO:0017085	1/129	response to insecticide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]
EOG88GZH5	GO:0051966	1/129	regulation of synaptic transmission, glutamatergic	biological_process	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
EOG88GZH3	GO:0016787	2/148	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG88GZH3	GO:0005509	1/148	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8Z0DKJ	GO:0005634	15/111	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z0DKJ	GO:0003677	15/111	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Z0DKJ	GO:0016059	1/111	deactivation of rhodopsin mediated signaling	biological_process	"The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831]
EOG8Z0DKJ	GO:0042803	1/111	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8Z0DKJ	GO:0045944	1/111	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8Z0DKJ	GO:0009416	1/111	response to light stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
EOG8Z0DKJ	GO:0045893	1/111	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Z0DKJ	GO:0005516	1/111	calmodulin binding	molecular_function	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
EOG8Z0DKJ	GO:0001077	1/111	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG8Z0DKJ	GO:0003700	1/111	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z0DKM	GO:0033314	1/83	mitotic DNA replication checkpoint	biological_process	"A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mtg_cell_cycle]
EOG8Z0DKM	GO:0005634	1/83	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GF5XW	GO:0042302	5/15	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG82C0RV	GO:0006412	2/70	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG82C0RV	GO:0005762	2/70	mitochondrial large ribosomal subunit	cellular_component	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
EOG82C0RV	GO:0005840	2/70	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG82C0RV	GO:0003735	2/70	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8G1PW9	GO:0016192	23/89	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8G1PW9	GO:0006886	23/89	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8G1PW9	GO:0008270	21/89	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8G1PW9	GO:0035542	1/89	regulation of SNARE complex assembly	biological_process	"Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
EOG8G1PW9	GO:0033263	1/89	CORVET complex	cellular_component	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]
EOG8G1PW9	GO:0006728	1/89	pteridine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732]
EOG8G1PW9	GO:0007298	1/89	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8G1PW9	GO:0005768	1/89	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG8G1PW9	GO:0006622	1/89	protein targeting to lysosome	biological_process	"The process of directing proteins towards the lysosome using signals contained within the protein." [GOC:curators]
EOG8G1PW9	GO:0008057	1/89	eye pigment granule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295]
EOG8G1PW9	GO:0051301	1/89	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8G1PW9	GO:0007220	1/89	Notch receptor processing	biological_process	"The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]
EOG8G1PW9	GO:0007032	1/89	endosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]
EOG8G1PW9	GO:0006726	1/89	eye pigment biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
EOG8G1PW9	GO:0008333	1/89	endosome to lysosome transport	biological_process	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]
EOG8G1PW9	GO:0005764	1/89	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8G1PW9	GO:0005765	1/89	lysosomal membrane	cellular_component	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]
EOG8G1PW9	GO:0031902	1/89	late endosome membrane	cellular_component	"The lipid bilayer surrounding a late endosome." [GOC:pz]
EOG8G1PW9	GO:0006897	1/89	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8G1PW9	GO:0030897	1/89	HOPS complex	cellular_component	"A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161]
EOG8G1PW9	GO:0008340	1/89	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8G1PW9	GO:0005515	1/89	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8G1PW9	GO:0045202	1/89	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8G1PW9	GO:0016197	1/89	endosomal transport	biological_process	"The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]
EOG8G1PW9	GO:0006727	1/89	ommochrome biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
EOG8G1PW9	GO:0048072	1/89	compound eye pigmentation	biological_process	"Establishment of a pattern of pigment in the compound eye." [GOC:jid]
EOG84N16Z	GO:0003677	1/4	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84N16Z	GO:0009360	1/4	DNA polymerase III complex	cellular_component	"The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork." [PMID:11525729, PMID:12940977, UniProt:P06710]
EOG84N16Z	GO:0005524	1/4	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG84N16Z	GO:0003887	1/4	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG84N16Z	GO:0017111	1/4	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG84N16G	GO:0005328	263/840	neurotransmitter:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
EOG84N16G	GO:0016021	251/840	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84N16G	GO:0003333	12/840	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG84N16G	GO:0005887	12/840	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84N16G	GO:0042940	11/840	D-amino acid transport	biological_process	"The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
EOG84N16G	GO:0042943	11/840	D-amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
EOG84N16G	GO:0005283	11/840	sodium:amino acid symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai]
EOG84N16G	GO:0015804	11/840	neutral amino acid transport	biological_process	"The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84N16G	GO:0015175	11/840	neutral amino acid transmembrane transporter activity	molecular_function	"Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG84N16G	GO:0006814	11/840	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84N16G	GO:0005326	7/840	neurotransmitter transporter activity	molecular_function	"Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732]
EOG84N16G	GO:0006836	7/840	neurotransmitter transport	biological_process	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]
EOG84N16G	GO:0005886	2/840	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG84N16G	GO:0019811	1/840	cocaine binding	molecular_function	"Interacting selectively and non-covalently with cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis." [GOC:jl, ISBN:0198506732]
EOG84N16G	GO:0015872	1/840	dopamine transport	biological_process	"The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
EOG84N16G	GO:0015222	1/840	serotonin transmembrane transporter activity	molecular_function	"Enables the transfer of serotonin from one side of the membrane to the other. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
EOG84N16G	GO:0004181	1/840	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG84N16G	GO:0015179	1/840	L-amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
EOG84N16G	GO:0030431	1/840	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG84N16G	GO:0042745	1/840	circadian sleep/wake cycle	biological_process	"The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com]
EOG84N16G	GO:0043679	1/840	axon terminus	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl]
EOG84N16G	GO:0015807	1/840	L-amino acid transport	biological_process	"The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah]
EOG84N16G	GO:0006909	1/840	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG84N16G	GO:0010226	1/840	response to lithium ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:tb]
EOG84N16G	GO:1902475	1/840	L-alpha-amino acid transmembrane transport	biological_process	"The directed movement of L-alpha-amino acid across a membrane." [GOC:kmv, GOC:TermGenie, PMID:14668347]
EOG84N16G	GO:0005416	1/840	cation:amino acid symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai]
EOG84N16G	GO:0046872	1/840	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84N16G	GO:0005261	1/840	cation channel activity	molecular_function	"Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG84N16G	GO:0030424	1/840	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG84N16G	GO:0008270	1/840	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84N16G	GO:0015844	1/840	monoamine transport	biological_process	"The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:25375, GOC:mah]
EOG84N16G	GO:0051610	1/840	serotonin uptake	biological_process	"The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
EOG84N16G	GO:0006837	1/840	serotonin transport	biological_process	"The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
EOG84N16G	GO:0008504	1/840	monoamine transmembrane transporter activity	molecular_function	"Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other." [CHEBI:25375, GOC:mah]
EOG84N16G	GO:0005329	1/840	dopamine transmembrane transporter activity	molecular_function	"Enables the transfer of dopamine from one side of the membrane to the other. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
EOG84N16G	GO:0007632	1/840	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG84N16F	GO:0005578	21/86	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG84N16F	GO:0005886	21/86	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG84N16F	GO:0031225	21/86	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG84N16F	GO:0007480	1/86	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG84N16F	GO:0007409	1/86	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG84N16F	GO:0008407	1/86	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG84N16F	GO:0007476	1/86	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG84N16F	GO:0035220	1/86	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG84N16F	GO:0030513	1/86	positive regulation of BMP signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators]
EOG84N16F	GO:0009986	1/86	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG84N16F	GO:0030718	1/86	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG84N16F	GO:0008101	1/86	decapentaplegic signaling pathway	biological_process	"A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:sart, PMID:17428827]
EOG84N16F	GO:0048190	1/86	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG84N16F	GO:0008045	1/86	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG84N16F	GO:0008586	1/86	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG84N16F	GO:0048749	1/86	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG84N16F	GO:0040014	1/86	regulation of multicellular organism growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG84N16F	GO:2001261	1/86	negative regulation of semaphorin-plexin signaling pathway	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of semaphorin-plexin signaling pathway." [GOC:BHF]
EOG84N16F	GO:0030510	1/86	regulation of BMP signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah]
EOG84N16F	GO:0051726	1/86	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG84N16F	GO:0007472	1/86	wing disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG84N16F	GO:0045570	1/86	regulation of imaginal disc growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators]
EOG84N16F	GO:0048813	1/86	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG84N16F	GO:0005515	1/86	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG84N16F	GO:0022416	1/86	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG84N16F	GO:0048132	1/86	female germ-line stem cell asymmetric division	biological_process	"The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu]
EOG84N16F	GO:0016055	1/86	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG84N16F	GO:0008052	1/86	sensory organ boundary specification	biological_process	"The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained." [GO_REF:0000021, GOC:mtg_15jun06]
EOG84N16C	GO:0005509	17/87	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8SN44B	GO:0005737	1/8	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SN44B	GO:0000105	1/8	histidine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]
EOG8SN44B	GO:0000107	1/8	imidazoleglycerol-phosphate synthase activity	molecular_function	"Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+)." [MetaCyc:GLUTAMIDOTRANS-RXN]
EOG84N16H	GO:0046872	1/51	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84N16H	GO:0001189	1/51	RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript	biological_process	"The aggregation, arrangement and bonding together of proteins on CORE promoter element DNA of the nuclear large ribosomal RNA (rRNA) transcript to form a transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from the large rRNA promoter, resulting in the subsequent synthesis of the large rRNA transcript." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832]
EOG84N16H	GO:0005730	1/51	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG84N16H	GO:0001164	1/51	RNA polymerase I CORE element sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
EOG84N16H	GO:0001187	1/51	transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting	molecular_function	"Interacting selectively and non-covalently with the CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery and also binding to an RNA polymerase I (RNAP I) transcription factor to recruit it to the transcription machinery complex in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832]
EOG84N167	GO:0005524	26/89	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG84N167	GO:0004674	24/89	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG84N167	GO:0004697	2/89	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG84N167	GO:0007144	1/89	female meiosis I	biological_process	"The cell cycle process in which the first meiotic division occurs in the female germline." [GOC:mah]
EOG84N167	GO:0006468	1/89	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG84N167	GO:0040020	1/89	regulation of meiotic nuclear division	biological_process	"Any process that modulates the frequency, rate or extent of meiosis, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma]
EOG84N167	GO:0005634	1/89	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84N167	GO:0005515	1/89	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG84N167	GO:0005635	1/89	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG84N167	GO:0007067	1/89	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG84N167	GO:0007143	1/89	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG84N167	GO:0030261	1/89	chromosome condensation	biological_process	"The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG84N167	GO:0004672	1/89	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG84N167	GO:0007088	1/89	regulation of mitotic nuclear division	biological_process	"Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
EOG84N167	GO:0005737	1/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84N167	GO:0034048	1/89	negative regulation of protein phosphatase type 2A activity	biological_process	"Any process that stops or reduces the activity of the enzyme protein phosphatase type 2A." [GOC:mah]
EOG84N167	GO:0007346	1/89	regulation of mitotic cell cycle	biological_process	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG84N167	GO:0046602	1/89	regulation of mitotic centrosome separation	biological_process	"Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis." [GOC:ai]
EOG84N167	GO:0071889	1/89	14-3-3 protein binding	molecular_function	"Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins." [GOC:cna, GOC:mah, InterPro:IPR000308, PMID:15167810, PMID:19575580, PR:000003237]
EOG8G1PWP	GO:0016021	83/226	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G1PWP	GO:0055085	83/226	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8G1PWP	GO:0008643	1/226	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8G1PWP	GO:0046872	1/226	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RBT1M	GO:0005634	84/201	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RBT1M	GO:0006351	83/201	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8RBT1M	GO:0003677	79/201	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RBT1M	GO:0006355	79/201	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8RBT1M	GO:0003700	5/201	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8RBT1M	GO:0048749	5/201	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8RBT1M	GO:0043565	5/201	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8RBT1M	GO:0007219	4/201	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8RBT1M	GO:0000122	4/201	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8RBT1M	GO:0005515	2/201	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8RBT1M	GO:0008134	2/201	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8RBT1M	GO:0030154	2/201	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8RBT1M	GO:0007399	2/201	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8RBT1M	GO:0048666	1/201	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8RBT1M	GO:0002052	1/201	positive regulation of neuroblast proliferation	biological_process	"Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph]
EOG8RBT1M	GO:2001020	1/201	regulation of response to DNA damage stimulus	biological_process	"Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
EOG8RBT1M	GO:0001964	1/201	startle response	biological_process	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
EOG8RBT1M	GO:0048190	1/201	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8RBT1M	GO:0045466	1/201	R7 cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339]
EOG8RBT1M	GO:0001078	1/201	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
EOG8RBT1M	GO:0048813	1/201	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8RBT1M	GO:0048052	1/201	R1/R6 cell differentiation	biological_process	"The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid]
EOG8RBT1M	GO:0031987	1/201	locomotion involved in locomotory behavior	biological_process	"Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
EOG8RBT1M	GO:0048854	1/201	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG841SRR	GO:0016021	10/159	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG841SRR	GO:0022857	9/159	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG841SRR	GO:0003677	2/159	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG841SRR	GO:0000278	1/159	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG841SRR	GO:0016905	1/159	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG841SRR	GO:0042023	1/159	DNA endoreduplication	biological_process	"Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw]
EOG841SRR	GO:0005215	1/159	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG841SRR	GO:0055085	1/159	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG841SRR	GO:0035185	1/159	preblastoderm mitotic cell cycle	biological_process	"The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238]
EOG8RBT1N	GO:0003677	1/44	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RBT1N	GO:0004402	1/44	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8RNDQ3	GO:0005634	27/127	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RNDQ3	GO:0003677	26/127	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RNDQ3	GO:0042742	1/127	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8RNDQ3	GO:0000166	1/127	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8RNDQ3	GO:0008270	1/127	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG873S5V	GO:0000175	1/4	3'-5'-exoribonuclease activity	molecular_function	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]
EOG873S5V	GO:0003723	1/4	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG873S5V	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG873S5V	GO:0006396	1/4	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG873S5V	GO:0004654	1/4	polyribonucleotide nucleotidyltransferase activity	molecular_function	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.8]
EOG873S5V	GO:0006402	1/4	mRNA catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]
EOG8JHFW3	GO:0016491	83/244	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8JHFW3	GO:0046592	2/244	polyamine oxidase activity	molecular_function	"Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380]
EOG8JHFW3	GO:0046872	1/244	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8JHFW3	GO:0050232	1/244	putrescine oxidase activity	molecular_function	"Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2." [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN]
EOG8JHFW3	GO:0005615	1/244	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8JHFW3	GO:0003676	1/244	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JHFW2	GO:0007050	7/50	cell cycle arrest	biological_process	"A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]
EOG88WFFS	GO:0003735	1/49	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG88WFFS	GO:0015934	1/49	large ribosomal subunit	cellular_component	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]
EOG88WFFS	GO:0035091	1/49	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG88WFFS	GO:0006412	1/49	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG88GZHQ	GO:0008521	56/126	acetyl-CoA transporter activity	molecular_function	"Enables the directed movement of acetyl-CoA into, out of or within a cell, or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai]
EOG88GZHQ	GO:0016021	56/126	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88GZHQ	GO:0005869	2/126	dynactin complex	cellular_component	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]
EOG8HQH0Z	GO:0019894	1/80	kinesin binding	molecular_function	"Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]
EOG886BSP	GO:0032934	26/112	sterol binding	molecular_function	"Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [CHEBI:15889, GOC:mah]
EOG886BSP	GO:0016491	23/112	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG886BSP	GO:0033989	2/112	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity	molecular_function	"Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O." [EC:4.2.1.107]
EOG886BSP	GO:0005777	2/112	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG886BSP	GO:0004300	1/112	enoyl-CoA hydratase activity	molecular_function	"Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.17]
EOG886BSP	GO:0005811	1/112	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG886BSP	GO:0033540	1/112	fatty acid beta-oxidation using acyl-CoA oxidase	biological_process	"A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5136]
EOG886BSP	GO:0042803	1/112	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG886BSP	GO:0080023	1/112	3R-hydroxyacyl-CoA dehydratase activity	molecular_function	"Catalysis of the reaction: 3R-hydroxyacyl-CoA = 2E-enoyl-CoA + H2O." [PMID:16982622]
EOG886BSP	GO:0016616	1/112	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG886BSP	GO:0004303	1/112	estradiol 17-beta-dehydrogenase activity	molecular_function	"Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62]
EOG8ZW7SF	GO:0008519	7/19	ammonium transmembrane transporter activity	molecular_function	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [GOC:go_curators, ISBN:0198506732]
EOG8ZW7SF	GO:0016021	7/19	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88GZHC	GO:0006066	2/23	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG88GZHC	GO:0050660	2/23	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG88GZHC	GO:0008812	2/23	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG8ZW7SQ	GO:0005509	1/24	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG88GZHJ	GO:0046872	26/118	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG88GZHJ	GO:0003676	26/118	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8S4RXX	GO:0003924	1/9	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8S4RXX	GO:0016151	1/9	nickel cation binding	molecular_function	"Interacting selectively and non-covalently with nickel (Ni) cations." [GOC:ai]
EOG8S4RXX	GO:0005524	1/9	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8S4RXX	GO:0005737	1/9	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8S4RXX	GO:0016530	1/9	metallochaperone activity	molecular_function	"Assists in the delivery of metal ions to target proteins or compartments." [GOC:jl, PMID:11739376]
EOG8SJ7TM	GO:0005245	51/275	voltage-gated calcium channel activity	molecular_function	"Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
EOG8SJ7TM	GO:0005891	51/275	voltage-gated calcium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]
EOG8SJ7TM	GO:0005509	24/275	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8SJ7TM	GO:0005216	8/275	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8SJ7TM	GO:0016021	8/275	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SJ7TM	GO:0086010	2/275	membrane depolarization during action potential	biological_process	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
EOG8SJ7TM	GO:0070509	2/275	calcium ion import	biological_process	"The directed movement of calcium ions into a cell or organelle." [GOC:mah]
EOG8SJ7TM	GO:0042045	2/275	epithelial fluid transport	biological_process	"The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830]
EOG8SJ7TM	GO:0016324	2/275	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8SJ7TM	GO:0006816	2/275	calcium ion transport	biological_process	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8SJ7TM	GO:0008331	2/275	high voltage-gated calcium channel activity	molecular_function	"Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]
EOG8SJ7TM	GO:0016323	2/275	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG8SJ7TM	GO:0008344	1/275	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG8SJ7TM	GO:0002027	1/275	regulation of heart rate	biological_process	"Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008]
EOG8SJ7TM	GO:0007619	1/275	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG8SJ7TM	GO:0008332	1/275	low voltage-gated calcium channel activity	molecular_function	"Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]
EOG8SJ7TM	GO:0007275	1/275	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8SJ7TM	GO:0046872	1/275	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8SJ7TM	GO:0007269	1/275	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8SJ7TM	GO:0045887	1/275	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8SJ7TM	GO:0045433	1/275	male courtship behavior, veined wing generated song production	biological_process	"The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
EOG8SJ7TM	GO:0007632	1/275	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG8SJ7TM	GO:0046928	1/275	regulation of neurotransmitter secretion	biological_process	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
EOG8SJ7TM	GO:0007602	1/275	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG8SJ7TM	GO:0007268	1/275	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8SJ7TM	GO:0006936	1/275	muscle contraction	biological_process	"A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]
EOG8SJ7TM	GO:0050908	1/275	detection of light stimulus involved in visual perception	biological_process	"The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
EOG8SJ7TM	GO:0048786	1/275	presynaptic active zone	cellular_component	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
EOG8SJ7TM	GO:0006887	1/275	exocytosis	biological_process	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
EOG8CNT6C	GO:0003964	574/3445	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8CNT6C	GO:0003723	549/3445	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CNT6C	GO:0008270	159/3445	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CNT6C	GO:0003676	89/3445	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CNT6C	GO:0004523	26/3445	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8CNT6C	GO:0005198	8/3445	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8CNT6C	GO:0005882	8/3445	intermediate filament	cellular_component	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
EOG8CNT6C	GO:0004519	5/3445	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8CNT6C	GO:0003677	5/3445	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CNT6C	GO:0046872	4/3445	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CNT6C	GO:0015074	4/3445	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8CNT6C	GO:0016021	3/3445	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CNT6C	GO:0004871	2/3445	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8CNT6C	GO:0000166	1/3445	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8CNT6C	GO:0006310	1/3445	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8CNT6C	GO:0004555	1/3445	alpha,alpha-trehalase activity	molecular_function	"Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28]
EOG8CNT6C	GO:0016874	1/3445	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8CNT6C	GO:0005991	1/3445	trehalose metabolic process	biological_process	"The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]
EOG8CNT6C	GO:0016881	1/3445	acid-amino acid ligase activity	molecular_function	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
EOG8CNT6C	GO:0016020	1/3445	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CNT6C	GO:0005549	1/3445	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8CNT6C	GO:0005622	1/3445	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8CNT6C	GO:0005215	1/3445	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8CNT6C	GO:0080019	1/3445	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8CNT6C	GO:0003887	1/3445	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8CNT6C	GO:0016787	1/3445	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8CNT6C	GO:0022857	1/3445	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8CNT6C	GO:0004984	1/3445	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8CNT6Z	GO:0016021	22/92	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CNT6Z	GO:0007163	1/92	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8CNT6Z	GO:0005918	1/92	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG8JDKNT	GO:0006511	26/94	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8JDKNT	GO:0000502	1/94	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG8JDKNT	GO:0006508	1/94	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8JDKNT	GO:0032436	1/94	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	biological_process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]
EOG8JDKNT	GO:0098586	1/94	cellular response to virus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:dos]
EOG84TRNN	GO:0016787	9/57	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG84TRNN	GO:0007528	1/57	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG84TRNN	GO:0004872	1/57	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG84TRNN	GO:0051124	1/57	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG84TRNN	GO:0007416	1/57	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG84TRNN	GO:0009986	1/57	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG84TRNN	GO:0005887	1/57	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84TRNN	GO:0031594	1/57	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG84TRNN	GO:0052689	1/57	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG84TRNN	GO:0042043	1/57	neurexin family protein binding	molecular_function	"Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals." [GOC:curators, GOC:pr, PMID:18923512]
EOG84TRNN	GO:0004104	1/57	cholinesterase activity	molecular_function	"Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8]
EOG8KSRZW	GO:0003676	91/283	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KSRZW	GO:0005515	3/283	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KSRZW	GO:0003723	3/283	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8KSRZW	GO:0060213	3/283	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	biological_process	"Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]
EOG8KSRZW	GO:0005737	3/283	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8KSRZW	GO:0006342	2/283	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG8KSRZW	GO:0007279	2/283	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8KSRZW	GO:0034584	2/283	piRNA binding	molecular_function	"Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]
EOG8KSRZW	GO:0016246	2/283	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG8KSRZW	GO:0010529	2/283	negative regulation of transposition	biological_process	"Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]
EOG8KSRZW	GO:0043186	2/283	P granule	cellular_component	"A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
EOG8KSRZW	GO:0048132	1/283	female germ-line stem cell asymmetric division	biological_process	"The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu]
EOG8KSRZW	GO:0001709	1/283	cell fate determination	biological_process	"A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
EOG8KSRZW	GO:0000785	1/283	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG8KSRZW	GO:0005654	1/283	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG8KSRZW	GO:0016441	1/283	posttranscriptional gene silencing	biological_process	"The inactivation of gene expression by a posttranscriptional mechanism." [GOC:mah, PMID:15020054]
EOG8KSRZW	GO:0071013	1/283	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8KSRZW	GO:0046011	1/283	regulation of oskar mRNA translation	biological_process	"Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512]
EOG8KSRZW	GO:0070725	1/283	Yb body	cellular_component	"A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell." [GOC:sart, PMID:19433453]
EOG8KSRZW	GO:0005700	1/283	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8KSRZW	GO:0046594	1/283	maintenance of pole plasm mRNA location	biological_process	"The process of maintaining mRNA in a specific location in the oocyte pole plasm. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:tb]
EOG8KSRZW	GO:0000335	1/283	negative regulation of transposition, DNA-mediated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc, GOC:tb]
EOG8KSRZW	GO:0045089	1/283	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8KSRZW	GO:0035194	1/283	posttranscriptional gene silencing by RNA	biological_process	"Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation." [GOC:mah, PMID:15020054, PMID:15066275, PMID:15066283]
EOG8KSRZW	GO:0006446	1/283	regulation of translational initiation	biological_process	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG8KSRZW	GO:0007275	1/283	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8KSRZW	GO:0005875	1/283	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8KSRZW	GO:0070868	1/283	heterochromatin organization involved in chromatin silencing	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah]
EOG8KSRZW	GO:0005634	1/283	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8KSRZW	GO:0007317	1/283	regulation of pole plasm oskar mRNA localization	biological_process	"Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb]
EOG8KSRZW	GO:0031047	1/283	gene silencing by RNA	biological_process	"Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054]
EOG8KSRZW	GO:0048477	1/283	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8KSRZW	GO:0050829	1/283	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8KSRZW	GO:0010369	1/283	chromocenter	cellular_component	"A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure." [PMID:12384572, PMID:15053486, PMID:16831888]
EOG8KSRZW	GO:0071011	1/283	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8KSRZW	GO:0007076	1/283	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8KSRZW	GO:0001556	1/283	oocyte maturation	biological_process	"A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, http://ovary.stanford.edu]
EOG8KSRZW	GO:0000398	1/283	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8KSRZW	GO:0031933	1/283	telomeric heterochromatin	cellular_component	"Heterochromatic regions of the chromosome found at the telomeres." [GOC:mah]
EOG8KSRZW	GO:0030718	1/283	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8KSRZW	GO:0035282	1/283	segmentation	biological_process	"The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689]
EOG8KSRZW	GO:0030717	1/283	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG8KSRZW	GO:0030423	1/283	targeting of mRNA for destruction involved in RNA interference	biological_process	"The process in which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674]
EOG8KSRZW	GO:0046012	1/283	positive regulation of oskar mRNA translation	biological_process	"Any process that activates or increases the frequency, rate or extent of oskar mRNA translation." [GOC:go_curators]
EOG8KSRZW	GO:0007318	1/283	pole plasm protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
EOG8KSRZW	GO:0042078	1/283	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG8KSRZW	GO:0046843	1/283	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8KSRZW	GO:0000791	1/283	euchromatin	cellular_component	"A dispersed and relatively uncompacted form of chromatin." [GOC:elh]
EOG8KSRZW	GO:0048133	1/283	male germ-line stem cell asymmetric division	biological_process	"The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes." [GOC:jid]
EOG8ZGRSP	GO:0016021	8/67	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZGRSP	GO:0004930	6/67	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8NCPTW	GO:0003677	20/79	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NCPTW	GO:0003676	10/79	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KSRZK	GO:0005524	11/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KSRZK	GO:0004674	9/91	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8KSRZK	GO:0004687	1/91	myosin light chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18]
EOG8KSRZK	GO:0004672	1/91	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8XWJCT	GO:0016021	29/112	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XWJCT	GO:0008519	29/112	ammonium transmembrane transporter activity	molecular_function	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [GOC:go_curators, ISBN:0198506732]
EOG8HQH0N	GO:0005230	3/11	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8HQH0N	GO:0016021	3/11	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HQH0N	GO:0045202	2/11	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8HQH0N	GO:0030054	2/11	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8HQH0N	GO:0005886	2/11	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8THZ7J	GO:0016021	25/88	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8THZ7J	GO:0005337	25/88	nucleoside transmembrane transporter activity	molecular_function	"Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai]
EOG837TW8	GO:0016787	3/78	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG837TW8	GO:0016791	1/78	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG8616JD	GO:0005524	29/133	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8616JD	GO:0004713	25/133	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8616JD	GO:0005509	19/133	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8616JD	GO:0007156	19/133	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8616JD	GO:0016021	18/133	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8616JD	GO:0004715	2/133	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8616JD	GO:0004714	2/133	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8616JD	GO:0004672	2/133	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8616JD	GO:0006468	1/133	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8616JD	GO:0090303	1/133	positive regulation of wound healing	biological_process	"Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF]
EOG8616JD	GO:0007030	1/133	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8616JD	GO:0016020	1/133	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8616JD	GO:0016772	1/133	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8616JD	GO:0045177	1/133	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8616JD	GO:0005887	1/133	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8616JD	GO:0045792	1/133	negative regulation of cell size	biological_process	"Any process that reduces cell size." [GOC:go_curators]
EOG8616JD	GO:0042060	1/133	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8616JD	GO:0018108	1/133	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG8616JD	GO:0016339	1/133	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
EOG8HQH0K	GO:0004047	24/87	aminomethyltransferase activity	molecular_function	"Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10]
EOG8HQH0K	GO:0005737	24/87	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HQH0K	GO:0006546	24/87	glycine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]
EOG8HQH0K	GO:0008483	24/87	transaminase activity	molecular_function	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]
EOG8HQH0K	GO:0005811	1/87	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8GB9P4	GO:0006334	304/573	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8GB9P4	GO:0000786	304/573	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8GB9P4	GO:0003677	304/573	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GB9P4	GO:0005634	303/573	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GB9P4	GO:0005515	23/573	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8GB9P4	GO:0008360	2/573	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8GB9P4	GO:0007140	2/573	male meiosis	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
EOG8GB9P4	GO:0005700	2/573	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8GB9P4	GO:0007155	2/573	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8GB9P4	GO:0003747	1/573	translation release factor activity	molecular_function	"Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]
EOG8S4RX5	GO:0004252	53/134	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8S4RX5	GO:0005576	2/134	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8S4RX5	GO:0003824	1/134	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8S4RX5	GO:0006508	1/134	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8S4RX4	GO:0016021	39/114	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S4RX4	GO:0005886	37/114	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8S4RX4	GO:0050909	34/114	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8S4RX4	GO:0008527	6/114	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8S4RX4	GO:0032098	1/114	regulation of appetite	biological_process	"Any process which modulates appetite, the desire or physical craving for food." [GOC:add]
EOG8S4RX4	GO:0033041	1/114	sweet taste receptor activity	molecular_function	"Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah]
EOG8S4RX4	GO:0060259	1/114	regulation of feeding behavior	biological_process	"Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." [GOC:BHF, GOC:dph, GOC:tb]
EOG8S4RX4	GO:0071332	1/114	cellular response to fructose stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:mah]
EOG8S4RX4	GO:0001582	1/114	detection of chemical stimulus involved in sensory perception of sweet taste	biological_process	"The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
EOG8S4RX4	GO:0050912	1/114	detection of chemical stimulus involved in sensory perception of taste	biological_process	"The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8S4RX4	GO:0008343	1/114	adult feeding behavior	biological_process	"Feeding behavior in a fully developed and mature organism." [GOC:mah]
EOG8S4RX4	GO:0050916	1/114	sensory perception of sweet taste	biological_process	"The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8X0Q8V	GO:0006281	5/37	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8X0Q8V	GO:0000723	5/37	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8X0Q8V	GO:0003678	5/37	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8K0T2T	GO:0006303	34/105	double-strand break repair via nonhomologous end joining	biological_process	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]
EOG8K0T2T	GO:0006310	34/105	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8K0T2T	GO:0042162	34/105	telomeric DNA binding	molecular_function	"Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]
EOG8K0T2T	GO:0000723	34/105	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8K0T2T	GO:0003684	34/105	damaged DNA binding	molecular_function	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
EOG8K0T2T	GO:0043564	34/105	Ku70:Ku80 complex	cellular_component	"Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983]
EOG8K0T2T	GO:0004003	20/105	ATP-dependent DNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl]
EOG8K0T2T	GO:0016817	13/105	hydrolase activity, acting on acid anhydrides	molecular_function	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]
EOG8K0T2T	GO:0005634	1/105	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8K0T2T	GO:0032508	1/105	DNA duplex unwinding	biological_process	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]
EOG8K0T2T	GO:0071480	1/105	cellular response to gamma radiation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah]
EOG8K0T2T	GO:0045747	1/105	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8K0T2T	GO:0008045	1/105	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8K0T2T	GO:0060702	1/105	negative regulation of endoribonuclease activity	biological_process	"Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb]
EOG8K0T2T	GO:0008428	1/105	ribonuclease inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:ai]
EOG8K0T2T	GO:0004519	1/105	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8616JK	GO:0005524	25/94	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8616JK	GO:0004715	20/94	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8616JK	GO:0005634	19/94	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8616JK	GO:0000287	19/94	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8616JK	GO:0007067	19/94	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8616JK	GO:0004674	11/94	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8616JK	GO:0004984	1/94	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8616JK	GO:0004672	1/94	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8616JK	GO:0018108	1/94	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG8616JK	GO:0051299	1/94	centrosome separation	biological_process	"The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai]
EOG8616JK	GO:0004713	1/94	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8616JK	GO:0004930	1/94	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8616JK	GO:0016021	1/94	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8616JK	GO:0045736	1/94	negative regulation of cyclin-dependent protein serine/threonine kinase activity	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]
EOG8616JK	GO:0006468	1/94	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8616JK	GO:0005875	1/94	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8616JK	GO:0051642	1/94	centrosome localization	biological_process	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
EOG8616JK	GO:0001700	1/94	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8616JK	GO:0005549	1/94	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8616JK	GO:0005886	1/94	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8616JK	GO:0007093	1/94	mitotic cell cycle checkpoint	biological_process	"A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle]
EOG8616JK	GO:0051225	1/94	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG8616JK	GO:0000278	1/94	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8D55BH	GO:0004872	1/119	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8D55BH	GO:0016021	1/119	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D55BH	GO:0007411	1/119	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8D55BH	GO:0030424	1/119	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8D55BH	GO:0030426	1/119	growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194]
EOG8D55BH	GO:0031290	1/119	retinal ganglion cell axon guidance	biological_process	"The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs]
EOG8D55BH	GO:0005886	1/119	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8D55BH	GO:0072499	1/119	photoreceptor cell axon guidance	biological_process	"The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
EOG8K0T2G	GO:0051056	12/100	regulation of small GTPase mediated signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
EOG8K0T2G	GO:0005083	12/100	GTPase regulator activity	molecular_function	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
EOG8K0T2G	GO:0005096	12/100	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8K0T2G	GO:0003964	4/100	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8K0T2G	GO:0008270	4/100	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8K0T2G	GO:0003723	4/100	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8K0T2G	GO:0015074	3/100	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8K0T2G	GO:0004190	1/100	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8ZGRSN	GO:0005524	53/187	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZGRSN	GO:0004674	47/187	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8ZGRSN	GO:0004672	6/187	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8ZGRSN	GO:0006468	2/187	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8ZGRSN	GO:0005515	2/187	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8ZGRSN	GO:0045732	2/187	positive regulation of protein catabolic process	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]
EOG8ZGRSN	GO:0005737	2/187	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZGRSN	GO:0016055	2/187	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG8ZGRSN	GO:0032436	2/187	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	biological_process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]
EOG8ZGRSN	GO:0005634	2/187	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZGRSN	GO:0004709	2/187	MAP kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
EOG8ZGRSN	GO:0042752	1/187	regulation of circadian rhythm	biological_process	"Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]
EOG8ZGRSN	GO:0022008	1/187	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8ZGRSN	GO:0031145	1/187	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [PMID:15380083]
EOG8ZGRSN	GO:0030071	1/187	regulation of mitotic metaphase/anaphase transition	biological_process	"Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle." [GOC:mah]
EOG8ZGRSN	GO:0042067	1/187	establishment of ommatidial planar polarity	biological_process	"The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
EOG8ZGRSN	GO:0007446	1/187	imaginal disc growth	biological_process	"The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387]
EOG8ZGRSN	GO:0046777	1/187	protein autophosphorylation	biological_process	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
EOG8ZGRSN	GO:0042306	1/187	regulation of protein import into nucleus	biological_process	"Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl]
EOG8ZGRSN	GO:0030307	1/187	positive regulation of cell growth	biological_process	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8ZGRSN	GO:0048148	1/187	behavioral response to cocaine	biological_process	"Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid]
EOG8ZGRSN	GO:0002121	1/187	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8ZGRSN	GO:0004715	1/187	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8ZGRSN	GO:0030163	1/187	protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]
EOG8ZGRSN	GO:0016310	1/187	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG8ZGRSN	GO:0007622	1/187	rhythmic behavior	biological_process	"The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr]
EOG8ZGRSN	GO:0030162	1/187	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8ZGRSN	GO:0005680	1/187	anaphase-promoting complex	cellular_component	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]
EOG8ZGRSN	GO:0007154	1/187	cell communication	biological_process	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]
EOG8ZGRSN	GO:0001737	1/187	establishment of imaginal disc-derived wing hair orientation	biological_process	"Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]
EOG8ZGRSN	GO:0005886	1/187	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8ZGRSN	GO:0051781	1/187	positive regulation of cell division	biological_process	"Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai]
EOG8ZGRSN	GO:0030111	1/187	regulation of Wnt signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]
EOG8ZGRSN	GO:0006281	1/187	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8ZGRSN	GO:0007623	1/187	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG8ZGRSN	GO:0006909	1/187	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8ZGRSN	GO:0045475	1/187	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8ZGRSN	GO:0016301	1/187	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8ZGRSN	GO:0045879	1/187	negative regulation of smoothened signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG8ZGRSN	GO:0030431	1/187	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8ZGRSN	GO:0000902	1/187	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8ZGRSN	GO:0008062	1/187	eclosion rhythm	biological_process	"The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043]
EOG8ZGRSN	GO:0043066	1/187	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8JDKP8	GO:0016021	27/86	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JDKP8	GO:0006810	26/86	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8JDKP8	GO:0009953	10/86	dorsal/ventral pattern formation	biological_process	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8JDKP8	GO:0000003	1/86	reproduction	biological_process	"The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732]
EOG8JDKP8	GO:0048193	1/86	Golgi vesicle transport	biological_process	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG8JDKP8	GO:0007311	1/86	maternal specification of dorsal/ventral axis, oocyte, germ-line encoded	biological_process	"Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8JDKP8	GO:0048042	1/86	regulation of post-mating oviposition	biological_process	"Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb, PMID:11932766]
EOG8JDKP8	GO:0005215	1/86	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8S1WNG	GO:0046872	26/92	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8S1WNG	GO:0003676	24/92	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8S1WNG	GO:0003677	4/92	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8S1WNG	GO:0005634	3/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8S1WNG	GO:0006351	3/92	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8S1WNG	GO:0006355	2/92	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8S1WNG	GO:0016568	1/92	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG8S1WNG	GO:0043565	1/92	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8S1WNG	GO:0031936	1/92	negative regulation of chromatin silencing	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah]
EOG8S1WNG	GO:0000785	1/92	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG8S1WNG	GO:0045892	1/92	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8S1WNG	GO:0005515	1/92	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8S1WNG	GO:0043035	1/92	chromatin insulator sequence binding	molecular_function	"Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795]
EOG8S1WNG	GO:0005700	1/92	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG834ZMP	GO:0003676	8/83	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K0T2M	GO:0003997	51/180	acyl-CoA oxidase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6]
EOG8K0T2M	GO:0005777	51/180	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8K0T2M	GO:0003995	51/180	acyl-CoA dehydrogenase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]
EOG8K0T2M	GO:0006635	48/180	fatty acid beta-oxidation	biological_process	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]
EOG8K0T2M	GO:0050660	48/180	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8K0T2M	GO:0006631	3/180	fatty acid metabolic process	biological_process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]
EOG8K0T2M	GO:0004970	1/180	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8K0T2M	GO:0005234	1/180	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8K0T2M	GO:0016020	1/180	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8K0T2M	GO:0006909	1/180	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8S1WNN	GO:0016021	25/76	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S1WNN	GO:0016485	25/76	protein processing	biological_process	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]
EOG8S1WNN	GO:0055037	1/76	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG8S1WNN	GO:0007219	1/76	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8S1WNN	GO:0045314	1/76	regulation of compound eye photoreceptor development	biological_process	"Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
EOG8S1WNN	GO:0007010	1/76	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8S1WNN	GO:0046331	1/76	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8S1WNN	GO:0070765	1/76	gamma-secretase complex	cellular_component	"A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein." [GOC:mah, PMID:15286082, PMID:15890777, PMID:17047368]
EOG8S1WNN	GO:0006509	1/76	membrane protein ectodomain proteolysis	biological_process	"The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/]
EOG8S1WNN	GO:0008594	1/76	photoreceptor cell morphogenesis	biological_process	"The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
EOG8S1WNN	GO:0005770	1/76	late endosome	cellular_component	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
EOG8S1WNN	GO:0007220	1/76	Notch receptor processing	biological_process	"The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]
EOG8S1WNN	GO:0045463	1/76	R8 cell development	biological_process	"The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium." [PMID:11880339]
EOG8RV569	GO:0035556	24/79	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8QC3MX	GO:0005220	1/3	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	molecular_function	"Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts." [GOC:mah, GOC:signaling, PMID:8660280, Wikipedia:Inositol_trisphosphate_receptor]
EOG8QC3MX	GO:0016020	1/3	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QC3MX	GO:0005783	1/3	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8NW216	GO:0006909	1/75	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG84BDGS	GO:0005634	30/97	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84BDGS	GO:0003700	30/97	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG84BDGS	GO:0035329	15/97	hippo signaling	biological_process	"The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1." [PMID:17318211, PMID:18328423]
EOG84BDGS	GO:0008134	1/97	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG84BDGS	GO:0005515	1/97	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG84BDGS	GO:0000980	1/97	RNA polymerase II distal enhancer sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH]
EOG84BDGS	GO:0006366	1/97	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG84BDGS	GO:0044212	1/97	transcription regulatory region DNA binding	molecular_function	"Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836]
EOG84BDGS	GO:0006665	1/97	sphingolipid metabolic process	biological_process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]
EOG84BDGS	GO:0019904	1/97	protein domain specific binding	molecular_function	"Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators]
EOG84BDGS	GO:0004348	1/97	glucosylceramidase activity	molecular_function	"Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45]
EOG84BDGS	GO:0007049	1/97	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG84BDGS	GO:0007423	1/97	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG84BDGS	GO:0055013	1/97	cardiac muscle cell development	biological_process	"The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state." [GOC:devbiol, GOC:mtg_heart]
EOG84BDGS	GO:0072089	1/97	stem cell proliferation	biological_process	"The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
EOG84BDGS	GO:0007525	1/97	somatic muscle development	biological_process	"The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
EOG84BDGS	GO:0007480	1/97	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG84BDGS	GO:0005975	1/97	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG84BDGS	GO:0035331	1/97	negative regulation of hippo signaling	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf]
EOG84BDGS	GO:0007476	1/97	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG84BDGS	GO:0035220	1/97	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG84BDGS	GO:0001745	1/97	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG84BDGS	GO:0046872	1/97	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84BDGS	GO:0045944	1/97	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8MKQXJ	GO:0007264	26/83	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8MKQXJ	GO:0005525	26/83	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8MKQXJ	GO:0005622	2/83	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8MKQXJ	GO:0004045	1/83	aminoacyl-tRNA hydrolase activity	molecular_function	"Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]
EOG84BDGW	GO:0005874	22/56	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG84BDGW	GO:0005524	22/56	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG84BDGW	GO:0005871	22/56	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG84BDGW	GO:0007018	22/56	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG84BDGW	GO:0003777	22/56	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG84BDGW	GO:0008152	1/56	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8WM7B8	GO:0016021	1/12	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FBM8G	GO:0046872	24/133	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8FBM8G	GO:0007476	1/133	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8FBM8G	GO:0009790	1/133	embryo development	biological_process	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
EOG8FBM8G	GO:0000381	1/133	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8FBM8G	GO:0003676	1/133	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FBM8G	GO:0003677	1/133	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FBM8G	GO:0001751	1/133	compound eye photoreceptor cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
EOG8FBM8G	GO:0007601	1/133	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8FBM8G	GO:0007525	1/133	somatic muscle development	biological_process	"The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
EOG8FBM8G	GO:0048471	1/133	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8FBM8G	GO:0046716	1/133	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG8FBM8G	GO:0005737	1/133	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8FBM8G	GO:0042052	1/133	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8FBM8G	GO:0007422	1/133	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8FBM8G	GO:0006915	1/133	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8FBM8G	GO:0007517	1/133	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8FBM8G	GO:0045924	1/133	regulation of female receptivity	biological_process	"Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8FBM8G	GO:0005634	1/133	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FBM8G	GO:0010468	1/133	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8MKQXF	GO:0003676	7/27	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MKQXD	GO:0016706	20/157	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG8MKQXD	GO:0006281	15/157	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8MKQXD	GO:0003677	14/157	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8MKQXD	GO:0005622	13/157	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8MKQXD	GO:0004519	12/157	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8MKQXD	GO:0003906	2/157	DNA-(apurinic or apyrimidinic site) lyase activity	molecular_function	"Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18]
EOG8MKQXD	GO:0005634	1/157	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8MKQXD	GO:0004518	1/157	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8MKQXD	GO:0090305	1/157	nucleic acid phosphodiester bond hydrolysis	biological_process	"The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
EOG8MKQXD	GO:0006974	1/157	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8MKQXD	GO:0000737	1/157	DNA catabolic process, endonucleolytic	biological_process	"The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
EOG8MKQXD	GO:0046872	1/157	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8MKQXD	GO:0008408	1/157	3'-5' exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]
EOG8MKQXD	GO:0008440	1/157	inositol-1,4,5-trisphosphate 3-kinase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11023]
EOG8JDKNM	GO:0050790	38/89	regulation of catalytic activity	biological_process	"Any process that modulates the activity of an enzyme." [GOC:ai]
EOG8JDKNM	GO:0004197	38/89	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8JDKNM	GO:0035071	1/89	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8JDKNM	GO:0008234	1/89	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8JDKNM	GO:0048102	1/89	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8PZMPV	GO:0009055	24/85	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8PZMPV	GO:0046872	24/85	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8PZMPV	GO:0051537	22/85	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8PZMPV	GO:0051536	2/85	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG880M9W	GO:0005509	7/178	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG880M9W	GO:0042384	1/178	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG880M9W	GO:0030425	1/178	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG880M9W	GO:0048814	1/178	regulation of dendrite morphogenesis	biological_process	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG880M9W	GO:0043195	1/178	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG880M9W	GO:0051124	1/178	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG880M9W	GO:0043025	1/178	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8JDKN4	GO:0043565	24/103	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8JDKN4	GO:0003700	24/103	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8JDKN4	GO:0005634	24/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8JDKN4	GO:0006357	14/103	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8JDKN4	GO:0006950	5/103	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8JDKN4	GO:0000785	1/103	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG8JDKN4	GO:0031427	1/103	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG8JDKN4	GO:0050832	1/103	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8JDKN4	GO:0042802	1/103	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG8JDKN4	GO:0005515	1/103	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8JDKN4	GO:0045892	1/103	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8JDKN4	GO:0042742	1/103	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8JDKN4	GO:0043388	1/103	positive regulation of DNA binding	biological_process	"Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
EOG8JDKN4	GO:0022008	1/103	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8JDKN4	GO:0045944	1/103	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8JDKN4	GO:0009408	1/103	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8JDKN4	GO:0005700	1/103	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8JDKN4	GO:0003677	1/103	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8JDKN4	GO:0045893	1/103	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8JDKN4	GO:0006351	1/103	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG81G5K1	GO:0020037	134/349	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG81G5K1	GO:0005506	134/349	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG81G5K1	GO:0016705	98/349	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG81G5K1	GO:0004497	92/349	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG81G5K1	GO:0070330	36/349	aromatase activity	molecular_function	"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
EOG81G5K1	GO:0005789	2/349	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG81G5K1	GO:0009055	1/349	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG81G5K1	GO:0018676	1/349	(S)-limonene 7-monooxygenase activity	molecular_function	"Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (4S)-perillyl alcohol + H(2)O + NADP(+)." [EC:1.14.13.49, RHEA:23435]
EOG81G5K1	GO:0004508	1/349	steroid 17-alpha-monooxygenase activity	molecular_function	"Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O." [EC:1.14.99.9]
EOG81G5K1	GO:0007423	1/349	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG83JFJW	GO:0003700	17/60	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG83JFJW	GO:0005634	17/60	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83JFJW	GO:0003676	2/60	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83JFJW	GO:0022008	1/60	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG83JFJW	GO:0046872	1/60	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83JFJW	GO:0007549	1/60	dosage compensation	biological_process	"Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes." [GOC:ems, ISBN:0140512888, PMID:11498577]
EOG86HJQG	GO:0005813	4/86	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG86HJQG	GO:0005634	4/86	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86HJQG	GO:0060271	4/86	cilium morphogenesis	biological_process	"A process that is carried out at the cellular level and in which the structure of a cilium is organized." [GOC:BHF, GOC:dph]
EOG86HJQG	GO:0042048	1/86	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG86HJQF	GO:0007018	38/185	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG86HJQF	GO:0003777	38/185	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG86HJQF	GO:0005524	34/185	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG86HJQF	GO:0016887	32/185	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG86HJQF	GO:0030286	29/185	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG86HJQF	GO:0042623	2/185	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG86HJQF	GO:0016539	2/185	intein-mediated protein splicing	biological_process	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]
EOG86HJQF	GO:0006200	2/185	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG86HJQF	GO:0006355	1/185	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG86HJQF	GO:0005858	1/185	axonemal dynein complex	cellular_component	"A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. May contain two or three dynein heavy chains as well as several light chains." [ISBN:0815316194]
EOG86HJQF	GO:0007605	1/185	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG86HJQF	GO:0005634	1/185	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86HJQF	GO:0005875	1/185	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG84BDG0	GO:0004252	20/102	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG84BDG0	GO:0016020	4/102	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG84BDG0	GO:0005044	4/102	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG84BDG0	GO:0007343	1/102	egg activation	biological_process	"The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751]
EOG84BDG0	GO:0007313	1/102	maternal specification of dorsal/ventral axis, oocyte, soma encoded	biological_process	"Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG84BDG0	GO:0008236	1/102	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG84BDG0	GO:0008233	1/102	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG84BDG0	GO:0007306	1/102	eggshell chorion assembly	biological_process	"Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG84BDG0	GO:0005578	1/102	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG84BDG0	GO:0016485	1/102	protein processing	biological_process	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]
EOG84BDG0	GO:0009950	1/102	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG84BDG0	GO:0008063	1/102	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG84BDG0	GO:0007310	1/102	oocyte dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG84BDG0	GO:0006508	1/102	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG84BDG4	GO:0008270	8/53	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84BDG9	GO:0006869	4/29	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG84BDG9	GO:0008270	1/29	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84BDG9	GO:0004222	1/29	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8PZMP4	GO:0005524	1/8	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8PZMP4	GO:0016887	1/8	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8JDKPK	GO:0031032	28/308	actomyosin structure organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]
EOG8JDKPK	GO:0003779	3/308	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8JDKPK	GO:0007520	1/308	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG8JDKPK	GO:0008360	1/308	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8JDKPK	GO:0004252	1/308	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8JDKPK	GO:1901739	1/308	regulation of myoblast fusion	biological_process	"Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]
EOG8JDKPK	GO:0006939	1/308	smooth muscle contraction	biological_process	"A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
EOG8JDKPK	GO:0005865	1/308	striated muscle thin filament	cellular_component	"Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194]
EOG8JDKPK	GO:0005515	1/308	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8JDKPK	GO:0070594	1/308	juvenile hormone response element binding	molecular_function	"Interacting selectively and non-covalently with the juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone." [GOC:sart, PMID:17956872]
EOG8JDKPK	GO:0035626	1/308	juvenile hormone mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of juvenile hormone to a receptor, and ending with regulation of cell state or activity." [GOC:bf, GOC:sart]
EOG8JDKPK	GO:0007155	1/308	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8S1WN5	GO:0005524	80/238	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8S1WN5	GO:0016020	73/238	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8S1WN5	GO:0042626	70/238	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8S1WN5	GO:0016887	6/238	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8S1WN5	GO:0015408	4/238	ferric-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [EC:3.6.3.30]
EOG8S1WN5	GO:0005886	1/238	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8ZSCKW	GO:0030036	26/93	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8ZSCKW	GO:0005856	21/93	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8ZSCKW	GO:0005737	2/93	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZSCKW	GO:0007420	1/93	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG8ZSCKW	GO:0005515	1/93	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8ZSCKW	GO:0000281	1/93	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8ZSCKW	GO:0045451	1/93	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8ZSCKW	GO:0000902	1/93	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8ZSCKW	GO:0007015	1/93	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8ZSCKW	GO:0048471	1/93	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8ZSCKW	GO:0000915	1/93	actomyosin contractile ring assembly	biological_process	"The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
EOG8ZSCKW	GO:0007300	1/93	ovarian nurse cell to oocyte transport	biological_process	"Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8ZSCKW	GO:0030717	1/93	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG8ZSCKW	GO:0035193	1/93	larval central nervous system remodeling	biological_process	"Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster." [GOC:sensu, PMID:9647692]
EOG8ZSCKW	GO:0030041	1/93	actin filament polymerization	biological_process	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG8ZSCKW	GO:0032507	1/93	maintenance of protein location in cell	biological_process	"Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah]
EOG8ZSCKW	GO:0007391	1/93	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8ZSCKW	GO:0007488	1/93	histoblast morphogenesis	biological_process	"The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238]
EOG8ZSCKW	GO:0007411	1/93	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8ZSCKW	GO:0042060	1/93	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8ZSCKW	GO:0007283	1/93	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8ZSCKW	GO:0007436	1/93	larval salivary gland morphogenesis	biological_process	"The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8ZSCKW	GO:0003779	1/93	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8ZSCKW	GO:0051491	1/93	positive regulation of filopodium assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG8HDW7B	GO:0045475	1/146	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8HDW7B	GO:0072347	1/146	response to anesthetic	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart]
EOG8VDSGH	GO:0003676	1/12	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VDSGH	GO:0015074	1/12	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG80S2XB	GO:0006351	1/47	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG80S2XB	GO:0006355	1/47	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG80S2XB	GO:0004871	1/47	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG80S2XB	GO:0005634	1/47	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80S2XB	GO:0003677	1/47	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG834ZM0	GO:0008381	37/162	mechanically-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]
EOG834ZM0	GO:0016021	37/162	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG834ZM0	GO:0003676	8/162	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG834ZM0	GO:0008270	8/162	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG834ZM0	GO:0003723	1/162	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG834ZM0	GO:0071260	1/162	cellular response to mechanical stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:mah]
EOG834ZM0	GO:0007638	1/162	mechanosensory behavior	biological_process	"Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators]
EOG834ZM0	GO:0034220	1/162	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG834ZM0	GO:0003964	1/162	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG81G5N3	GO:0003676	1/34	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG81G5N3	GO:0000166	1/34	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG834ZM6	GO:0005856	23/88	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG834ZM6	GO:0046621	1/88	negative regulation of organ growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
EOG834ZM6	GO:0040008	1/88	regulation of growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]
EOG834ZM6	GO:0008101	1/88	decapentaplegic signaling pathway	biological_process	"A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:sart, PMID:17428827]
EOG834ZM6	GO:0007050	1/88	cell cycle arrest	biological_process	"A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]
EOG834ZM6	GO:0006351	1/88	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG834ZM6	GO:0045571	1/88	negative regulation of imaginal disc growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators]
EOG834ZM6	GO:0001751	1/88	compound eye photoreceptor cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
EOG834ZM6	GO:0001745	1/88	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG834ZM6	GO:0036375	1/88	Kibra-Ex-Mer complex	cellular_component	"An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2." [PMID:20159598]
EOG834ZM6	GO:0009966	1/88	regulation of signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]
EOG834ZM6	GO:0016324	1/88	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG834ZM6	GO:0035331	1/88	negative regulation of hippo signaling	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf]
EOG834ZM6	GO:0008285	1/88	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG834ZM6	GO:0035330	1/88	regulation of hippo signaling	biological_process	"Any process that modulates the frequency, rate or extent of hippo signaling." [GOC:bf]
EOG834ZM6	GO:0042981	1/88	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG834ZM6	GO:0045892	1/88	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG834ZM6	GO:0007096	1/88	regulation of exit from mitosis	biological_process	"Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn]
EOG834ZM6	GO:0005515	1/88	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG834ZM6	GO:0032456	1/88	endocytic recycling	biological_process	"The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635]
EOG834ZM6	GO:0045595	1/88	regulation of cell differentiation	biological_process	"Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]
EOG834ZM6	GO:0005915	1/88	zonula adherens	cellular_component	"A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208]
EOG834ZM6	GO:0046620	1/88	regulation of organ growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
EOG834ZM6	GO:0042327	1/88	positive regulation of phosphorylation	biological_process	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]
EOG834ZM6	GO:0035329	1/88	hippo signaling	biological_process	"The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1." [PMID:17318211, PMID:18328423]
EOG80GG5H	GO:0000502	1/92	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG80GG5H	GO:0022008	1/92	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG80GG5N	GO:0022008	1/77	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG841SR8	GO:0016567	1/112	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG841SR8	GO:0005634	1/112	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG841SR8	GO:0035212	1/112	cell competition in a multicellular organism	biological_process	"Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286]
EOG80GG5P	GO:0030170	1/7	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG80GG5P	GO:0008890	1/7	glycine C-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+)." [EC:2.3.1.29, RHEA:20739]
EOG80GG5P	GO:0009058	1/7	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG893614	GO:0003676	17/107	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG893614	GO:0004523	17/107	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG893614	GO:0003723	1/107	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG893614	GO:0003964	1/107	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG80P6RB	GO:0016491	1/2	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8N8TKX	GO:0006396	26/116	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8N8TKX	GO:0005622	20/116	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8N8TKX	GO:0005634	6/116	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8N8TKX	GO:0022008	1/116	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8D55BV	GO:0016787	51/385	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8D55BV	GO:0052689	4/385	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG8D55BV	GO:0008152	2/385	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8D55BV	GO:0005576	1/385	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8D55BV	GO:0008340	1/385	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8D55BV	GO:0005737	1/385	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8D55BV	GO:0005811	1/385	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8D55BV	GO:0007476	1/385	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8D55BV	GO:0060179	1/385	male mating behavior	biological_process	"The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb]
EOG8D55BV	GO:0003990	1/385	acetylcholinesterase activity	molecular_function	"Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
EOG8D55BV	GO:0019915	1/385	lipid storage	biological_process	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]
EOG8D55BV	GO:0046683	1/385	response to organophosphorus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544]
EOG8M3CQ4	GO:0003964	10/341	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8M3CQ4	GO:0003723	9/341	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8M3CQ4	GO:0005198	3/341	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8M3CQ4	GO:0005882	3/341	intermediate filament	cellular_component	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
EOG8M3CQ4	GO:0015074	2/341	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8M3CQ4	GO:0003677	2/341	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8M3CQ4	GO:0003676	2/341	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M3CQ4	GO:0007155	1/341	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8M3CQ4	GO:0009007	1/341	site-specific DNA-methyltransferase (adenine-specific) activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72]
EOG8M3CQ4	GO:0046872	1/341	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8M3CQ4	GO:0006310	1/341	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8M3CQ4	GO:0008168	1/341	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG880MFJ	GO:0080019	1/4	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8M3CQ3	GO:0000287	27/92	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8M3CQ3	GO:0051287	27/92	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8M3CQ3	GO:0004449	25/92	isocitrate dehydrogenase (NAD+) activity	molecular_function	"Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41]
EOG8M3CQ3	GO:0006099	24/92	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8M3CQ3	GO:0016616	2/92	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8M3CQ3	GO:0005524	1/92	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8M3CQ3	GO:0004674	1/92	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8M3CQ3	GO:0005875	1/92	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8N8TKR	GO:0051536	1/80	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8NGK26	GO:0004984	69/207	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8NGK26	GO:0005549	69/207	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8NGK26	GO:0004930	64/207	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8NGK26	GO:0016021	64/207	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NGK26	GO:0005886	49/207	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8NGK26	GO:0016020	5/207	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NGK26	GO:0050911	3/207	detection of chemical stimulus involved in sensory perception of smell	biological_process	"The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8NGK26	GO:0007608	2/207	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8NGK26	GO:0007186	2/207	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8NGK26	GO:0051291	1/207	protein heterooligomerization	biological_process	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
EOG8NGK26	GO:0032590	1/207	dendrite membrane	cellular_component	"The portion of the plasma membrane surrounding a dendrite." [GOC:mah]
EOG8NGK26	GO:0004888	1/207	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8K3PBJ	GO:0005525	28/85	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8K3PBJ	GO:0007264	28/85	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8K3PBJ	GO:0015031	25/85	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8K3PBJ	GO:0048072	1/85	compound eye pigmentation	biological_process	"Establishment of a pattern of pigment in the compound eye." [GOC:jid]
EOG8K3PBJ	GO:0006727	1/85	ommochrome biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
EOG8K3PBJ	GO:0006184	1/85	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8K3PBJ	GO:0045202	1/85	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8K3PBJ	GO:0003924	1/85	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8K3PBJ	GO:0005515	1/85	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8K3PBJ	GO:0055037	1/85	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG8K3PBJ	GO:0008355	1/85	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8K3PBJ	GO:0005764	1/85	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8K3PBJ	GO:0007611	1/85	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG8K3PBJ	GO:0005776	1/85	autophagosome	cellular_component	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]
EOG8K3PBJ	GO:0010883	1/85	regulation of lipid storage	biological_process	"Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
EOG8K3PBJ	GO:0004767	1/85	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8K3PBJ	GO:0006856	1/85	eye pigment precursor transport	biological_process	"The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8K3PBJ	GO:0008057	1/85	eye pigment granule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295]
EOG8K3PBJ	GO:0010506	1/85	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8GF5X2	GO:0019028	2/54	viral capsid	cellular_component	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
EOG8GF5X2	GO:0005198	2/54	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8HMMSJ	GO:0000723	4/40	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8HMMSJ	GO:0003678	4/40	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8HMMSJ	GO:0006281	4/40	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8HMMSJ	GO:0030414	1/40	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8HMMSJ	GO:0016706	1/40	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG8HMMSJ	GO:0005576	1/40	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8QJV1Z	GO:0007155	24/111	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8QJV1Z	GO:0006030	20/111	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8QJV1Z	GO:0005576	20/111	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8QJV1Z	GO:0008061	20/111	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8QJV1Z	GO:0042060	1/111	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8QJV1Z	GO:0047712	1/111	Cypridina-luciferin 2-monooxygenase activity	molecular_function	"Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light." [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN]
EOG8QJV1Z	GO:0042381	1/111	hemolymph coagulation	biological_process	"Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949]
EOG8QJV1Z	GO:0042803	1/111	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8QJV1Z	GO:0003676	1/111	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QJV1Z	GO:0007599	1/111	hemostasis	biological_process	"The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732]
EOG8QJV1Z	GO:0008270	1/111	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GF5XH	GO:0016592	24/77	mediator complex	cellular_component	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
EOG8GF5XH	GO:0001104	24/77	RNA polymerase II transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8GF5XH	GO:0006366	2/77	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8GF5XH	GO:0016192	1/77	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8GF5XH	GO:0016020	1/77	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8N8TK7	GO:0016021	26/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8N8TK7	GO:0004190	25/91	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8N8TK7	GO:0006465	1/91	signal peptide processing	biological_process	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]
EOG8N8TK7	GO:0006508	1/91	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8N8TK7	GO:0016020	1/91	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8N8TK7	GO:0005783	1/91	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8N8TK7	GO:0042500	1/91	aspartic endopeptidase activity, intramembrane cleaving	molecular_function	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732]
EOG8N8TK7	GO:0034620	1/91	cellular response to unfolded protein	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah]
EOG8N8TK3	GO:0004889	7/50	acetylcholine-activated cation-selective channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]
EOG8N8TK3	GO:0045211	7/50	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8N8TK3	GO:0030054	7/50	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8N8TK3	GO:0016021	7/50	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HHRGT	GO:0005622	44/112	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8HHRGT	GO:0046872	44/112	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HHRGT	GO:0035556	42/112	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8HHRGT	GO:0007266	2/112	Rho protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf]
EOG8HHRGT	GO:0030178	1/112	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8HHRGT	GO:0030154	1/112	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8HHRGT	GO:0032321	1/112	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8HHRGT	GO:0005634	1/112	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HHRGT	GO:0048813	1/112	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8HHRGT	GO:0007165	1/112	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8HHRGT	GO:0000281	1/112	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8HHRGT	GO:0001709	1/112	cell fate determination	biological_process	"A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
EOG8HHRGT	GO:0005100	1/112	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8HHRGT	GO:0051298	1/112	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8HHRGT	GO:0001745	1/112	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8HHRGT	GO:0022008	1/112	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8HHRGT	GO:0017048	1/112	Rho GTPase binding	molecular_function	"Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [ISBN:0198547684, PMID:12581856]
EOG8HHRGT	GO:0048666	1/112	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8HHRGT	GO:0030111	1/112	regulation of Wnt signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]
EOG8HHRGT	GO:0032507	1/112	maintenance of protein location in cell	biological_process	"Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah]
EOG8HHRGT	GO:0008283	1/112	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8HHRGT	GO:0007052	1/112	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8HHRGT	GO:0007283	1/112	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8HHRGT	GO:0034613	1/112	cellular protein localization	biological_process	"Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]
EOG8HHRGT	GO:0048471	1/112	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8HHRGT	GO:0007525	1/112	somatic muscle development	biological_process	"The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
EOG8HHRGT	GO:0070507	1/112	regulation of microtubule cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8HHRGT	GO:0005085	1/112	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG880MF0	GO:0004519	1/8	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG880MF0	GO:0003723	1/8	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG880MF0	GO:0003964	1/8	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG873S5H	GO:0008565	26/93	protein transporter activity	molecular_function	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
EOG873S5H	GO:0031204	26/93	posttranslational protein targeting to membrane, translocation	biological_process	"The process in which a protein translocates through the ER membrane posttranslationally." [PMID:12518317, PMID:8707814]
EOG873S5H	GO:0005622	24/93	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG873S5H	GO:0004830	1/93	tryptophan-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2]
EOG873S5H	GO:0005737	1/93	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG873S5H	GO:0045169	1/93	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG873S5H	GO:0005524	1/93	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG873S5H	GO:0006436	1/93	tryptophanyl-tRNA aminoacylation	biological_process	"The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8M3CQJ	GO:0007498	1/145	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8M3CQG	GO:0008060	27/86	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8M3CQG	GO:0032312	27/86	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8M3CQG	GO:0008270	27/86	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8M3CQG	GO:0032012	1/86	regulation of ARF protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]
EOG8M3CQG	GO:0043547	1/86	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8M3CQG	GO:0005795	1/86	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG8TQPPS	GO:0005086	25/100	ARF guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8TQPPS	GO:0032012	25/100	regulation of ARF protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]
EOG8TQPPS	GO:0043087	1/100	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8TQPPS	GO:0005802	1/100	trans-Golgi network	cellular_component	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]
EOG8TQPPS	GO:0003676	1/100	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8TQPPS	GO:0046872	1/100	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TQPPS	GO:0016192	1/100	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8TTJZV	GO:0004842	24/91	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8TTJZV	GO:0005634	24/91	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TTJZV	GO:0006511	24/91	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8TTJZV	GO:0008270	24/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TTJZV	GO:0007275	20/91	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8TTJZV	GO:0005737	4/91	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8TTJZV	GO:0007601	4/91	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8TTJZV	GO:0050896	4/91	response to stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
EOG8TTJZV	GO:0007423	4/91	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8TTJZV	GO:0045676	4/91	regulation of R7 cell differentiation	biological_process	"Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators]
EOG8TTJZV	GO:0016874	3/91	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8TTJZV	GO:0010498	1/91	proteasomal protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]
EOG8TTJZV	GO:0000151	1/91	ubiquitin ligase complex	cellular_component	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
EOG8TTJZV	GO:0042802	1/91	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG8TTJZV	GO:0005515	1/91	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8TTJZV	GO:0007465	1/91	R7 cell fate commitment	biological_process	"The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883]
EOG8TTJZV	GO:0043621	1/91	protein self-association	molecular_function	"Interacting selectively and non-covalently with a domain within the same polypeptide." [GOC:jl]
EOG8TTJZV	GO:0006508	1/91	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG883GKD	GO:0003682	1/26	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG883GKD	GO:0003677	1/26	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG841SRZ	GO:0006886	24/109	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG841SRZ	GO:0006505	24/109	GPI anchor metabolic process	biological_process	"The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732]
EOG841SRZ	GO:0016788	23/109	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG841SRZ	GO:0042578	1/109	phosphoric ester hydrolase activity	molecular_function	"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]
EOG841SRZ	GO:0005789	1/109	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG841SRZ	GO:0015798	1/109	myo-inositol transport	biological_process	"The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai]
EOG841SRZ	GO:0090305	1/109	nucleic acid phosphodiester bond hydrolysis	biological_process	"The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
EOG841SRZ	GO:0005783	1/109	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG841SRZ	GO:0004518	1/109	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG841SRZ	GO:0016021	1/109	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG841SRZ	GO:0008233	1/109	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG883GKC	GO:0005509	27/69	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG80GG58	GO:0003676	29/136	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80GG58	GO:0046872	29/136	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80GG58	GO:0005634	5/136	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SBHDJ	GO:0004385	24/92	guanylate kinase activity	molecular_function	"Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8]
EOG8SBHDJ	GO:0006163	24/92	purine nucleotide metabolic process	biological_process	"The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
EOG8SBHDJ	GO:0017111	2/92	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8SBHDJ	GO:0005524	2/92	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG80GG52	GO:0016021	24/95	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80GG52	GO:0006810	24/95	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG80GG52	GO:0005739	4/95	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG80GG51	GO:0004075	26/87	biotin carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]
EOG80GG51	GO:0046872	26/87	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80GG51	GO:0005524	26/87	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG80GG51	GO:0004485	3/87	methylcrotonoyl-CoA carboxylase activity	molecular_function	"Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate." [EC:6.4.1.4, RHEA:13592]
EOG8N06Z5	GO:0003677	4/6	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8N06Z5	GO:0005634	4/6	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8N06Z7	GO:0004930	1/4	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8N06Z7	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RNDQ1	GO:0046872	25/89	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RNDQ1	GO:0003676	24/89	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RNDQ1	GO:0035277	1/89	spiracle morphogenesis, open tracheal system	biological_process	"The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268]
EOG8RNDQ1	GO:0003677	1/89	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RNDQ1	GO:0005634	1/89	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RNDQ1	GO:0045892	1/89	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8RNDQ1	GO:0045893	1/89	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8RNDQ1	GO:0006351	1/89	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8N3339	GO:0007264	13/95	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8N3339	GO:0005622	13/95	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8N3339	GO:0005089	10/95	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8N3339	GO:0005085	3/95	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8N3339	GO:0051056	2/95	regulation of small GTPase mediated signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
EOG8N3339	GO:0016740	1/95	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8N3336	GO:0005856	24/92	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8N3336	GO:0030178	1/92	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8N3336	GO:0070201	1/92	regulation of establishment of protein localization	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah]
EOG8KPWST	GO:0016021	27/105	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KPWST	GO:0046872	1/105	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8KPWST	GO:0004784	1/105	superoxide dismutase activity	molecular_function	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]
EOG8KPWSS	GO:0008255	1/60	ecdysis-triggering hormone activity	molecular_function	"The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system." [GOC:mah, PMID:9020043]
EOG8KPWSS	GO:0018990	1/60	ecdysis, chitin-based cuticle	biological_process	"The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8KPWSS	GO:0005102	1/60	receptor binding	molecular_function	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]
EOG8KPWSS	GO:0005184	1/60	neuropeptide hormone activity	molecular_function	"The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]
EOG8KPWSS	GO:0001664	1/60	G-protein coupled receptor binding	molecular_function	"Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph]
EOG8KPWSS	GO:0007218	1/60	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8KPWSS	GO:0005615	1/60	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG880M9R	GO:0000723	3/13	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG880M9R	GO:0003678	3/13	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG880M9R	GO:0006281	3/13	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG880M9R	GO:0046872	1/13	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8X3KJG	GO:0016021	1/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG880M9D	GO:0005524	21/101	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG880M9D	GO:0016773	18/101	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG880M9D	GO:0016301	18/101	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG880M9D	GO:0004674	4/101	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG880M9D	GO:0007275	1/101	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG880M9D	GO:0035173	1/101	histone kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf]
EOG880M9D	GO:0016233	1/101	telomere capping	biological_process	"A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055]
EOG880M9D	GO:0000781	1/101	chromosome, telomeric region	cellular_component	"The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh]
EOG880M9D	GO:0005576	1/101	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG880M9D	GO:0006348	1/101	chromatin silencing at telomere	biological_process	"Repression of transcription of telomeric DNA by altering the structure of chromatin." [PMID:10219245]
EOG880M9D	GO:0007095	1/101	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG880M9D	GO:0000723	1/101	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG880M9D	GO:1990164	1/101	histone H2A phosphorylation	biological_process	"The modification of histone H2A by the addition of a phosphate group." [GOC:mah, PMID:23080121]
EOG880M9D	GO:0030717	1/101	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG880M9D	GO:0004672	1/101	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG880M9D	GO:0000706	1/101	meiotic DNA double-strand break processing	biological_process	"The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324]
EOG880M9D	GO:0016310	1/101	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG880M9D	GO:0051276	1/101	chromosome organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG880M9D	GO:0045494	1/101	photoreceptor cell maintenance	biological_process	"Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]
EOG880M9D	GO:0007093	1/101	mitotic cell cycle checkpoint	biological_process	"A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle]
EOG880M9D	GO:0005634	1/101	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG880M9D	GO:0016740	1/101	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8Q87F4	GO:0008344	1/67	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG8Q87F4	GO:0060457	1/67	negative regulation of digestive system process	biological_process	"Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb]
EOG8Q87F4	GO:0005184	1/67	neuropeptide hormone activity	molecular_function	"The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]
EOG8Q87F4	GO:0071855	1/67	neuropeptide receptor binding	molecular_function	"Interacting selectively and non-covalently with a neuropeptide receptor." [GOC:kmv, GOC:mah]
EOG8Q87F4	GO:0045822	1/67	negative regulation of heart contraction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators]
EOG8Q87F4	GO:0045986	1/67	negative regulation of smooth muscle contraction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
EOG8Q87F4	GO:0007218	1/67	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8Q87F4	GO:0005615	1/67	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8Q87F4	GO:0010459	1/67	negative regulation of heart rate	biological_process	"Any process that stops, prevents or reduces the frequency or rate of heart contraction." [GOC:dph, GOC:tb]
EOG8JWXT7	GO:0007519	1/166	skeletal muscle tissue development	biological_process	"The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
EOG8JWXT7	GO:0008307	1/166	structural constituent of muscle	molecular_function	"The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah]
EOG8JWXT7	GO:0016203	1/166	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8JWXT7	GO:0000794	1/166	condensed nuclear chromosome	cellular_component	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh]
EOG8JWXT7	GO:0007062	1/166	sister chromatid cohesion	biological_process	"The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other." [GOC:jh, GOC:mah, ISBN:0815316194]
EOG8JWXT7	GO:0035206	1/166	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8JWXT7	GO:0007522	1/166	visceral muscle development	biological_process	"The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators]
EOG8JWXT7	GO:0007525	1/166	somatic muscle development	biological_process	"The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
EOG8JWXT7	GO:0030018	1/166	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8JWXT7	GO:0003779	1/166	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8JWXT7	GO:0007076	1/166	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8JWXT7	GO:0040011	1/166	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG8JWXT7	GO:0007517	1/166	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8JWXT7	GO:0007520	1/166	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG8JWXT7	GO:0030017	1/166	sarcomere	cellular_component	"The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]
EOG8JWXT7	GO:0045214	1/166	sarcomere organization	biological_process	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
EOG8JWXT7	GO:0007498	1/166	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8JWXT7	GO:0005875	1/166	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8JWXT7	GO:0016301	1/166	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG81RS89	GO:0055085	250/817	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG81RS89	GO:0005215	250/817	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG81RS89	GO:0016021	249/817	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81RS89	GO:0016020	2/817	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG81RS89	GO:0006814	1/817	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG81RS89	GO:0051780	1/817	behavioral response to nutrient	biological_process	"Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus." [GOC:ai]
EOG81RS89	GO:0008343	1/817	adult feeding behavior	biological_process	"Feeding behavior in a fully developed and mature organism." [GOC:mah]
EOG81RS89	GO:0016323	1/817	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG81RS89	GO:0015293	1/817	symporter activity	molecular_function	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
EOG81RS89	GO:0007156	1/817	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG81RS89	GO:0005509	1/817	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8RZ1D6	GO:0016021	14/44	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RZ1D6	GO:0050909	12/44	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8RZ1D6	GO:0005886	12/44	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8RZ1D6	GO:0008527	2/44	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8RZ1D5	GO:0060271	7/94	cilium morphogenesis	biological_process	"A process that is carried out at the cellular level and in which the structure of a cilium is organized." [GOC:BHF, GOC:dph]
EOG8RZ1D5	GO:0005930	7/94	axoneme	cellular_component	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]
EOG8RZ1D5	GO:0045502	7/94	dynein binding	molecular_function	"Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules." [GOC:bf]
EOG8RZ1D5	GO:0007268	1/94	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8RZ1D8	GO:0003676	55/523	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RZ1D8	GO:0016301	3/523	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8RZ1D8	GO:0046872	2/523	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RZ1D8	GO:0005524	1/523	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8RZ1D8	GO:0004743	1/523	pyruvate kinase activity	molecular_function	"Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40]
EOG8RZ1D8	GO:0000287	1/523	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8RZ1D8	GO:0003723	1/523	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RZ1D8	GO:0008270	1/523	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RZ1D8	GO:0006096	1/523	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8RZ1D8	GO:0030955	1/523	potassium ion binding	molecular_function	"Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah]
EOG8RZ1D8	GO:0004672	1/523	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8RZ1D8	GO:0003964	1/523	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG86DPGZ	GO:0046872	9/50	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG86DPGZ	GO:0003677	8/50	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86DPGZ	GO:0005634	8/50	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86DPGZ	GO:0003682	8/50	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG86DPGZ	GO:0003676	1/50	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8PK4P8	GO:0006629	27/100	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8PK4P8	GO:0005576	26/100	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8PK4P8	GO:0004806	12/100	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG8PK4P8	GO:0016787	12/100	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8PK4P8	GO:0003824	3/100	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8PK4P8	GO:0007476	1/100	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8TTK28	GO:0046872	1/17	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG86Q982	GO:0008375	26/98	acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]
EOG86Q982	GO:0030158	26/98	protein xylosyltransferase activity	molecular_function	"Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate." [EC:2.4.2.26]
EOG86Q982	GO:0016020	24/98	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG86Q982	GO:0006024	24/98	glycosaminoglycan biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]
EOG86Q982	GO:0042732	2/98	D-xylose metabolic process	biological_process	"The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732]
EOG86Q982	GO:0030206	2/98	chondroitin sulfate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732]
EOG86Q982	GO:0005789	2/98	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG86Q982	GO:0000139	2/98	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG86Q982	GO:0015012	2/98	heparan sulfate proteoglycan biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210]
EOG86Q982	GO:0016021	2/98	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86Q982	GO:0050650	2/98	chondroitin sulfate proteoglycan biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]
EOG86Q982	GO:0016740	1/98	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG808QQB	GO:0016891	2/7	endoribonuclease activity, producing 5'-phosphomonoesters	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
EOG808QQB	GO:0042779	2/7	tRNA 3'-trailer cleavage	biological_process	"Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both." [GOC:go_curators]
EOG8RZ1DV	GO:0003677	10/252	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RZ1DV	GO:0015074	5/252	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8RZ1DV	GO:0006310	5/252	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8RZ1DV	GO:0003676	1/252	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RZ1DV	GO:0003723	1/252	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RZ1DV	GO:0003964	1/252	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8TTK2M	GO:0003677	1/2	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TTK2M	GO:0006355	1/2	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8TTK2M	GO:0000156	1/2	phosphorelay response regulator activity	molecular_function	"Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140]
EOG8TTK2M	GO:0016020	1/2	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RZ1DX	GO:0006633	132/423	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8RZ1DX	GO:0016021	132/423	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RZ1DX	GO:0016717	92/423	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]
EOG8RZ1DX	GO:0004768	40/423	stearoyl-CoA 9-desaturase activity	molecular_function	"Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1]
EOG8RZ1DX	GO:0005783	36/423	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8RZ1DX	GO:0005506	35/423	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8RZ1DX	GO:0060179	1/423	male mating behavior	biological_process	"The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb]
EOG8RZ1DX	GO:0042811	1/423	pheromone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]
EOG8RZ1DX	GO:0004984	1/423	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8RZ1DX	GO:0010506	1/423	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8RZ1DX	GO:0007619	1/423	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG8RZ1DX	GO:0005811	1/423	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8RZ1DX	GO:0048047	1/423	mating behavior, sex discrimination	biological_process	"The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700]
EOG8RZ1DX	GO:0042810	1/423	pheromone metabolic process	biological_process	"The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]
EOG8RZ1DX	GO:0042593	1/423	glucose homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]
EOG8RZ1DX	GO:0070328	1/423	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG8RZ1DX	GO:0000281	1/423	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8RZ1DX	GO:0006909	1/423	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8RZ1DX	GO:0031410	1/423	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG8RZ1DX	GO:0019216	1/423	regulation of lipid metabolic process	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
EOG8RZ1DX	GO:0005549	1/423	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8RZ1DX	GO:0009744	1/423	response to sucrose	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl]
EOG8RZ1DX	GO:0006723	1/423	cuticle hydrocarbon biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai]
EOG8642RQ	GO:0004525	29/109	ribonuclease III activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]
EOG8642RQ	GO:0003723	28/109	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8642RQ	GO:0006396	28/109	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8642RQ	GO:0004386	26/109	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8642RQ	GO:0005524	26/109	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8642RQ	GO:0003676	3/109	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8642RQ	GO:0016891	2/109	endoribonuclease activity, producing 5'-phosphomonoesters	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
EOG8642RQ	GO:0070883	1/109	pre-miRNA binding	molecular_function	"Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA." [PMID:18951094]
EOG8642RQ	GO:0003727	1/109	single-stranded RNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl]
EOG8642RQ	GO:0007367	1/109	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG8642RQ	GO:0016443	1/109	bidentate ribonuclease III activity	molecular_function	"Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference." [PMID:15242644]
EOG8642RQ	GO:0042078	1/109	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG8642RQ	GO:0003725	1/109	double-stranded RNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]
EOG8642RQ	GO:0045448	1/109	mitotic cell cycle, embryonic	biological_process	"The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators]
EOG8642RQ	GO:0046872	1/109	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8642RQ	GO:0031054	1/109	pre-miRNA processing	biological_process	"Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]
EOG8642RQ	GO:0016246	1/109	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG8642RQ	GO:0030727	1/109	germarium-derived female germ-line cyst formation	biological_process	"Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902]
EOG8642RQ	GO:0033227	1/109	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8642RQ	GO:0007294	1/109	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8642RQ	GO:0005737	1/109	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8642RQ	GO:0090501	1/109	RNA phosphodiester bond hydrolysis	biological_process	"The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
EOG8642RQ	GO:0030422	1/109	production of siRNA involved in RNA interference	biological_process	"Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674]
EOG8642RQ	GO:0035087	1/109	siRNA loading onto RISC involved in RNA interference	biological_process	"The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference." [GOC:bf, GOC:mah, PMID:14512631]
EOG8642RQ	GO:0035196	1/109	production of miRNAs involved in gene silencing by miRNA	biological_process	"Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein." [GOC:dph, GOC:tb, PMID:15066275, PMID:15066283]
EOG8642RQ	GO:0090502	1/109	RNA phosphodiester bond hydrolysis, endonucleolytic	biological_process	"The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
EOG8642RQ	GO:0007279	1/109	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8642RQ	GO:0016442	1/109	RISC complex	cellular_component	"A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]
EOG8642RQ	GO:0005515	1/109	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8642RQ	GO:0048813	1/109	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8V9X5D	GO:0003676	7/41	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG808QQS	GO:0003676	7/236	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG808QQS	GO:0008270	3/236	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RZ1DD	GO:0004721	2/82	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8RZ1DD	GO:0015031	1/82	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8RZ1DD	GO:0007163	1/82	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8RZ1DD	GO:0016021	1/82	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RZ1DD	GO:0005912	1/82	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8RZ1DD	GO:0015171	1/82	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG808QQX	GO:0005576	24/38	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG808QQX	GO:0032504	1/38	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG81RS8C	GO:0020037	56/125	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG81RS8C	GO:0005506	56/125	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG81RS8C	GO:0016705	53/125	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG81RS8C	GO:0004497	47/125	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG81RS8C	GO:0070330	2/125	aromatase activity	molecular_function	"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
EOG81RS8C	GO:0007552	1/125	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG81RS8C	GO:0035210	1/125	prepupal development	biological_process	"The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects that undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation." [GOC:mtg_sensu, http://sdb.bio.purdue.edu/fly/aimain/1adult.htm]
EOG81RS8C	GO:0007304	1/125	chorion-containing eggshell formation	biological_process	"The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG81RS8C	GO:0005789	1/125	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG81RS8C	GO:0016712	1/125	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
EOG81RS8C	GO:0007480	1/125	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG81RS8C	GO:0035074	1/125	pupation	biological_process	"The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238]
EOG81RS8C	GO:0008395	1/125	steroid hydroxylase activity	molecular_function	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]
EOG81RS8C	GO:0046344	1/125	ecdysteroid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:ai]
EOG81RS8C	GO:0016021	1/125	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RZ1DM	GO:0016772	18/78	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG889734	GO:0016747	48/150	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG889734	GO:0004144	7/150	diacylglycerol O-acyltransferase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20]
EOG889734	GO:0007498	1/150	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8ZPHBR	GO:0035299	21/82	inositol pentakisphosphate 2-kinase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H(+)." [EC:2.7.1.158, RHEA:20316]
EOG8ZPHBR	GO:0005524	21/82	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZPHBR	GO:0032958	1/82	inositol phosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, CHEBI:25448, GOC:mah]
EOG8RNDQR	GO:0007264	22/71	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8RNDQR	GO:0005525	22/71	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8RNDQR	GO:0015031	21/71	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8RNDQR	GO:0006260	1/71	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8RNDQR	GO:0005634	1/71	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RNDQR	GO:0055037	1/71	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG8RNDQR	GO:0004767	1/71	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8RNDQR	GO:0045202	1/71	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8RNDQR	GO:0000808	1/71	origin recognition complex	cellular_component	"A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh]
EOG8RNDQR	GO:0043025	1/71	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8W6R8Q	GO:0005543	21/112	phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8W6R8Q	GO:0008168	1/112	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8W6R8Q	GO:0008091	1/112	spectrin	cellular_component	"Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194]
EOG8W6R8Q	GO:0016324	1/112	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8W6R8Q	GO:0003676	1/112	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W6R8Q	GO:0030707	1/112	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8W6R8Q	GO:0010797	1/112	regulation of multivesicular body size involved in endosome transport	biological_process	"Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles." [GOC:dph, GOC:tb]
EOG8W6R8Q	GO:0032509	1/112	endosome transport via multivesicular body sorting pathway	biological_process	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]
EOG8W6R8Q	GO:0008092	1/112	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8W6R8Q	GO:0003779	1/112	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8W6R8Q	GO:0042060	1/112	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8W6R8Q	GO:0044267	1/112	cellular protein metabolic process	biological_process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]
EOG8W6R8Q	GO:0004725	1/112	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8W6R8Q	GO:0005524	1/112	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8W6R8Q	GO:0008017	1/112	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8W6R8Q	GO:0016327	1/112	apicolateral plasma membrane	cellular_component	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
EOG8W6R8Q	GO:0000281	1/112	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8W6R8Q	GO:0005515	1/112	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8W6R8Q	GO:0006897	1/112	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8W6R8Q	GO:0007009	1/112	plasma membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8W6R8Q	GO:0045186	1/112	zonula adherens assembly	biological_process	"Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf]
EOG8W6R8Q	GO:0005912	1/112	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8W6R8Q	GO:0016772	1/112	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8RBT03	GO:0008270	3/12	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RBT01	GO:0005788	1/80	endoplasmic reticulum lumen	cellular_component	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]
EOG8RBT01	GO:0015991	1/80	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8RBT01	GO:0016820	1/80	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	molecular_function	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]
EOG8RBT01	GO:0000221	1/80	vacuolar proton-transporting V-type ATPase, V1 domain	cellular_component	"The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG8RBT01	GO:0006616	1/80	SRP-dependent cotranslational protein targeting to membrane, translocation	biological_process	"The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen." [ISBN:0716731363]
EOG8RBT01	GO:0005783	1/80	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8W6R8T	GO:0005615	6/22	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8W6R8T	GO:0004866	4/22	endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl]
EOG8RNDQC	GO:0016021	30/176	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RNDQC	GO:0006633	28/176	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8RNDQC	GO:0016740	28/176	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8RNDQC	GO:0016491	26/176	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8RNDQC	GO:0009922	2/176	fatty acid elongase activity	molecular_function	"Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb]
EOG8RNDQC	GO:0030497	2/176	fatty acid elongation	biological_process	"The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094]
EOG8RNDQC	GO:0070524	2/176	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	molecular_function	"Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146]
EOG8RNDQC	GO:0042759	1/176	long-chain fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:go_curators]
EOG8RNDQC	GO:0042811	1/176	pheromone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]
EOG8RNDQC	GO:0018454	1/176	acetoacetyl-CoA reductase activity	molecular_function	"Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36]
EOG8RNDQC	GO:0019368	1/176	fatty acid elongation, unsaturated fatty acid	biological_process	"Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah]
EOG8RNDQC	GO:0004316	1/176	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
EOG8RBT05	GO:0005230	61/226	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8RBT05	GO:0016021	61/226	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RBT05	GO:0004890	52/226	GABA-A receptor activity	molecular_function	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333]
EOG8RBT05	GO:0005886	51/226	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8RBT05	GO:0030054	47/226	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8RBT05	GO:0045202	44/226	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8RBT05	GO:0006811	4/226	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8RBT05	GO:0045211	3/226	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8RBT05	GO:0034707	3/226	chloride channel complex	cellular_component	"An ion channel complex through which chloride ions pass." [GOC:mah]
EOG8RBT05	GO:0005254	3/226	chloride channel activity	molecular_function	"Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8RBT05	GO:0030594	2/226	neurotransmitter receptor activity	molecular_function	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]
EOG8RBT05	GO:0007165	2/226	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8RBT05	GO:0007268	2/226	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8RBT05	GO:0042493	1/226	response to drug	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl]
EOG8RBT05	GO:0030425	1/226	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8RBT05	GO:0042749	1/226	regulation of circadian sleep/wake cycle	biological_process	"Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." [GOC:jl]
EOG8RBT05	GO:0050805	1/226	negative regulation of synaptic transmission	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
EOG8RBT05	GO:0030424	1/226	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8RBT05	GO:0030431	1/226	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8RBT05	GO:0090328	1/226	regulation of olfactory learning	biological_process	"Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb]
EOG8RBT05	GO:0009612	1/226	response to mechanical stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]
EOG8G1PX8	GO:0004747	35/98	ribokinase activity	molecular_function	"Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [EC:2.7.1.15]
EOG8G1PX8	GO:0006014	35/98	D-ribose metabolic process	biological_process	"The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732]
EOG8G1PX8	GO:0003676	1/98	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8G1PX8	GO:0016829	1/98	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8G1PX8	GO:0055085	1/98	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8G1PX8	GO:0016021	1/98	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G1PX8	GO:0000166	1/98	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8TF30D	GO:0046872	28/91	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TF30D	GO:0003676	26/91	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8TF30D	GO:0003677	1/91	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TF30D	GO:0005634	1/91	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TF30D	GO:0045892	1/91	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8TF30D	GO:0043035	1/91	chromatin insulator sequence binding	molecular_function	"Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795]
EOG8TF30D	GO:0005515	1/91	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8TF30D	GO:0006349	1/91	regulation of gene expression by genetic imprinting	biological_process	"Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself." [GOC:ems, ISBN:0198506732, PMID:11498578]
EOG8TF30D	GO:0043007	1/91	maintenance of rDNA	biological_process	"Any process involved in sustaining the fidelity and copy number of rDNA repeats." [GOC:vw, PMID:14528010]
EOG8TF30D	GO:0007379	1/91	segment specification	biological_process	"The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8TF30D	GO:0043565	1/91	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8TF30B	GO:0005509	24/96	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8TF30B	GO:0005525	24/96	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8TF30B	GO:0007264	24/96	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8TF30B	GO:0003924	15/96	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8TF30B	GO:0019725	15/96	cellular homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172]
EOG8TF30B	GO:0005741	13/96	mitochondrial outer membrane	cellular_component	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
EOG8TF30B	GO:0005622	9/96	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8TF30B	GO:0047497	2/96	mitochondrion transport along microtubule	biological_process	"The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd]
EOG8TF30B	GO:0097345	2/96	mitochondrial outer membrane permeabilization	biological_process	"The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:pg, PMID:21041309]
EOG8TF30B	GO:0031307	2/96	integral component of mitochondrial outer membrane	cellular_component	"The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
EOG8TF30B	GO:0000287	1/96	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8TF30B	GO:0006184	1/96	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8TF30B	GO:0034643	1/96	establishment of mitochondrion localization, microtubule-mediated	biological_process	"The directed movement of the mitochondrion to a specific location, by a process involving microtubules." [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220]
EOG8TF30B	GO:0005515	1/96	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8TF30B	GO:0051646	1/96	mitochondrion localization	biological_process	"Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
EOG8TF30B	GO:0003676	1/96	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8TF30B	GO:0000226	1/96	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8TF30B	GO:0048489	1/96	synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr]
EOG8G1PX2	GO:0008081	25/78	phosphoric diester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]
EOG8G1PX2	GO:0006629	21/78	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8G1PX2	GO:0047396	5/78	glycosylphosphatidylinositol diacylglycerol-lyase activity	molecular_function	"Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate." [EC:4.6.1.14, MetaCyc:3.1.4.47-RXN]
EOG8G1PX2	GO:0006650	4/78	glycerophospholipid metabolic process	biological_process	"The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]
EOG8X99X6	GO:0045454	3/35	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8FJBPZ	GO:0016021	6/14	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84N17F	GO:0000179	3/64	rRNA (adenine-N6,N6-)-dimethyltransferase activity	molecular_function	"Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410]
EOG8QNQC3	GO:0003735	22/165	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8QNQC3	GO:0000166	22/165	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8QNQC3	GO:0005840	22/165	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8QNQC3	GO:0006412	22/165	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8QNQC3	GO:0042623	2/165	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8QNQC3	GO:0030286	2/165	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8QNQC3	GO:0007018	2/165	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8QNQC3	GO:0006200	2/165	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8QNQC3	GO:0051298	1/165	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8QNQC3	GO:0007283	1/165	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8QNQC3	GO:0005875	1/165	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8258B0	GO:0004930	1/4	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8258B0	GO:0016020	1/4	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8J9QD1	GO:0005524	114/470	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8J9QD1	GO:0003676	87/470	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8J9QD1	GO:0008026	87/470	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8J9QD1	GO:0004674	25/470	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8J9QD1	GO:0005875	3/470	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8J9QD1	GO:0005634	3/470	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8J9QD1	GO:0004712	3/470	protein serine/threonine/tyrosine kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]
EOG8J9QD1	GO:0004672	2/470	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8J9QD1	GO:0003724	2/470	RNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah]
EOG8J9QD1	GO:0000381	2/470	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8J9QD1	GO:0016779	2/470	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG8J9QD1	GO:0008152	2/470	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8J9QD1	GO:0009306	1/470	protein secretion	biological_process	"The controlled release of proteins from a cell." [GOC:ai]
EOG8J9QD1	GO:0007399	1/470	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8J9QD1	GO:0071011	1/470	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8J9QD1	GO:0048477	1/470	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8J9QD1	GO:0009882	1/470	blue light photoreceptor activity	molecular_function	"The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb]
EOG8J9QD1	GO:0005783	1/470	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8J9QD1	GO:0007350	1/470	blastoderm segmentation	biological_process	"The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8J9QD1	GO:0019730	1/470	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG8J9QD1	GO:0007548	1/470	sex differentiation	biological_process	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]
EOG8J9QD1	GO:0030717	1/470	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG8J9QD1	GO:0005737	1/470	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8J9QD1	GO:0007601	1/470	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8J9QD1	GO:0000398	1/470	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8J9QD1	GO:0042051	1/470	compound eye photoreceptor development	biological_process	"The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
EOG8J9QD1	GO:0048749	1/470	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8J9QD1	GO:0048854	1/470	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG8J9QD1	GO:0035071	1/470	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8J9QD1	GO:0031987	1/470	locomotion involved in locomotory behavior	biological_process	"Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
EOG8J9QD1	GO:0048102	1/470	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8J9QD1	GO:0006468	1/470	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8J9QD1	GO:0046777	1/470	protein autophosphorylation	biological_process	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
EOG8J9QD1	GO:0005515	1/470	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8J9QD1	GO:0005703	1/470	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG8J9QD1	GO:0004713	1/470	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8J9QD1	GO:0003729	1/470	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8J9QD1	GO:0016246	1/470	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG8J9QD1	GO:0022008	1/470	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8J9QD1	GO:2000255	1/470	negative regulation of male germ cell proliferation	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation." [GOC:obol]
EOG8J9QD1	GO:0005700	1/470	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8J9QD1	GO:0006417	1/470	regulation of translation	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8J9QD1	GO:0001964	1/470	startle response	biological_process	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
EOG8J9QD1	GO:0004386	1/470	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8J9QD1	GO:0071949	1/470	FAD binding	molecular_function	"Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]
EOG8J9QD1	GO:0071013	1/470	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8J9QD1	GO:0005829	1/470	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8THZ6V	GO:0003777	24/104	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8THZ6V	GO:0005871	24/104	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8THZ6V	GO:0005524	22/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8THZ6V	GO:0005874	22/104	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8THZ6V	GO:0007018	20/104	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8THZ6V	GO:0005737	4/104	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8THZ6V	GO:0005875	4/104	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8THZ6V	GO:0048489	4/104	synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr]
EOG8THZ6V	GO:0047496	4/104	vesicle transport along microtubule	biological_process	"The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl]
EOG8G7FDW	GO:0003677	2/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8G7FDW	GO:0003676	1/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8J9QD9	GO:0008233	12/75	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8J9QD9	GO:0004180	4/75	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8J9QD9	GO:0004177	3/75	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG8J9QD9	GO:0008168	1/75	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8J9QD9	GO:0003676	1/75	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80ZTCF	GO:0003676	49/794	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80ZTCF	GO:0003887	26/794	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG80ZTCF	GO:0000166	26/794	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG80ZTCF	GO:0046872	20/794	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80ZTCF	GO:0008408	11/794	3'-5' exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]
EOG80ZTCF	GO:0003677	11/794	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80ZTCF	GO:0009103	1/794	lipopolysaccharide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai, GOC:mr]
EOG80ZTCF	GO:0006353	1/794	DNA-templated transcription, termination	biological_process	"The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161]
EOG8DNHJ6	GO:0005524	9/61	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8DNHJ6	GO:0004674	9/61	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8DNHJ6	GO:0016758	1/61	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8DNHJ6	GO:0006506	1/61	GPI anchor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
EOG80ZTCK	GO:0006814	84/227	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG80ZTCK	GO:0016020	82/227	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG80ZTCK	GO:0055085	82/227	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG80ZTCK	GO:0005215	82/227	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG80ZTCK	GO:0008340	2/227	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG80ZTCK	GO:0015141	2/227	succinate transmembrane transporter activity	molecular_function	"Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of the membrane to the other." [ISBN:0198506732]
EOG80ZTCK	GO:0015744	2/227	succinate transport	biological_process	"The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG80ZTCK	GO:0006848	2/227	pyruvate transport	biological_process	"The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG80ZTCK	GO:0071422	2/227	succinate transmembrane transport	biological_process	"A process in which a succinate ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG80ZTCK	GO:0005887	2/227	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80ZTCK	GO:0015137	2/227	citrate transmembrane transporter activity	molecular_function	"Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other." [GOC:ai]
EOG80ZTCK	GO:0015746	2/227	citrate transport	biological_process	"The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG80ZTCK	GO:1901475	2/227	pyruvate transmembrane transport	biological_process	"The directed movement of pyruvate across a membrane." [GOC:TermGenie]
EOG80ZTCK	GO:0050833	2/227	pyruvate transmembrane transporter activity	molecular_function	"Enables the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other." [GOC:ai]
EOG80ZTCK	GO:0000077	1/227	DNA damage checkpoint	biological_process	"A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle]
EOG80ZTCK	GO:0016323	1/227	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG80ZTCK	GO:0005886	1/227	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80ZTCK	GO:0010889	1/227	regulation of sequestering of triglyceride	biological_process	"Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
EOG80ZTCK	GO:0030896	1/227	checkpoint clamp complex	cellular_component	"Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]
EOG8DNHJ5	GO:0006511	13/93	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8DNHJ5	GO:0004221	2/93	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG8DNHJ5	GO:0046666	1/93	retinal cell programmed cell death	biological_process	"Programmed cell death that occurs in the developing retina." [GOC:bf]
EOG8DNHJ5	GO:0016318	1/93	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG8DNHJ5	GO:0046667	1/93	compound eye retinal cell programmed cell death	biological_process	"Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672]
EOG8DNHJ5	GO:0008157	1/93	protein phosphatase 1 binding	molecular_function	"Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl]
EOG8DNHJ5	GO:0046672	1/93	positive regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG8PZMMR	GO:0017040	2/119	ceramidase activity	molecular_function	"Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23]
EOG8PZMMR	GO:0006665	2/119	sphingolipid metabolic process	biological_process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]
EOG8PZMMR	GO:0005576	2/119	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8PZMMR	GO:0005737	1/119	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8PZMMR	GO:0016079	1/119	synaptic vesicle exocytosis	biological_process	"Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
EOG8PZMMR	GO:0046514	1/119	ceramide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]
EOG8PZMMR	GO:0031629	1/119	synaptic vesicle fusion to presynaptic membrane	biological_process	"Fusion of the membrane of a synaptic vesicle with its target presynaptic membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [ISBN:0071120009]
EOG8PZMMR	GO:0007268	1/119	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8PZMMR	GO:0009415	1/119	response to water	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl]
EOG8PZMMR	GO:0006950	1/119	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8PZMMR	GO:0045494	1/119	photoreceptor cell maintenance	biological_process	"Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]
EOG8PZMMR	GO:0035187	1/119	hatching behavior	biological_process	"The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [GOC:pr, PMID:10436051]
EOG8PZMMP	GO:0005524	28/92	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8PZMMP	GO:0003676	28/92	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8PZMMP	GO:0008026	27/92	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8PZMMP	GO:0004004	1/92	ATP-dependent RNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8PZMMP	GO:0022008	1/92	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8PZMMP	GO:0071011	1/92	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8PZMMP	GO:0005682	1/92	U5 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U5." [GOC:krc, GOC:mah]
EOG8PZMMP	GO:0071013	1/92	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8PZMMP	GO:0000398	1/92	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8PZMMP	GO:0003918	1/92	DNA topoisomerase type II (ATP-hydrolyzing) activity	molecular_function	"Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192]
EOG8PZMMP	GO:0030532	1/92	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8PZMMP	GO:0006200	1/92	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG80ZTCP	GO:0036054	8/45	protein-malonyllysine demalonylase activity	molecular_function	"Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide." [GOC:sp, PMID:21908771, PMID:22076378]
EOG80ZTCP	GO:0070403	8/45	NAD+ binding	molecular_function	"Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
EOG80ZTCP	GO:0036055	8/45	protein-succinyllysine desuccinylase activity	molecular_function	"Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide." [GOC:sp, PMID:22076378]
EOG80ZTCP	GO:0005739	7/45	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG80ZTCP	GO:0034979	7/45	NAD-dependent protein deacetylase activity	molecular_function	"Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD." [GOC:BHF, GOC:mah]
EOG80ZTCP	GO:0008270	7/45	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8K9DSD	GO:0005524	28/92	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8K9DSD	GO:0004674	27/92	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8K9DSD	GO:0060252	1/92	positive regulation of glial cell proliferation	biological_process	"Any process that activates or increases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb]
EOG8K9DSD	GO:0016772	1/92	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8K9DSD	GO:0022008	1/92	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8K9DSD	GO:0004252	1/92	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8PZMMK	GO:0004970	24/96	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8PZMMK	GO:0005234	24/96	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8PZMMK	GO:0030054	23/96	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8PZMMK	GO:0016021	23/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PZMMK	GO:0045211	23/96	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8PZMMK	GO:0071683	1/96	sensory dendrite	cellular_component	"A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron." [GOC:dos, GOC:kmv, GOC:mah]
EOG8PZMMK	GO:0034220	1/96	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8PZMMK	GO:0008328	1/96	ionotropic glutamate receptor complex	cellular_component	"A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
EOG8PZMMK	GO:0035249	1/96	synaptic transmission, glutamatergic	biological_process	"The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv]
EOG8PZMMK	GO:0016020	1/96	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8PZMMK	GO:0005929	1/96	cilium	cellular_component	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:kmv, GOC:vw, ISBN:0198547684]
EOG8PZMMK	GO:0007608	1/96	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8PZMMK	GO:0015276	1/96	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8PZMMK	GO:0050907	1/96	detection of chemical stimulus involved in sensory perception	biological_process	"The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
EOG8PZMMK	GO:0035235	1/96	ionotropic glutamate receptor signaling pathway	biological_process	"A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732]
EOG8PZMMG	GO:0008270	25/88	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PZMMG	GO:0003677	3/88	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8PZMMG	GO:0018024	2/88	histone-lysine N-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]
EOG8PZMMG	GO:0004402	2/88	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8PZMMG	GO:0033563	1/88	dorsal/ventral axon guidance	biological_process	"The process in which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:kmv, GOC:tb]
EOG8K9DSM	GO:0006584	1/104	catecholamine metabolic process	biological_process	"The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
EOG8K9DSM	GO:0007126	1/104	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8K9DSM	GO:0005634	1/104	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8K9DSM	GO:0005700	1/104	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8K9DSM	GO:0004500	1/104	dopamine beta-monooxygenase activity	molecular_function	"Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O." [EC:1.14.17.1, RHEA:19120]
EOG8K9DSM	GO:0005737	1/104	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8K9DSM	GO:0005730	1/104	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8K9DSM	GO:0055114	1/104	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8K9DSM	GO:0005874	1/104	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8K9DSM	GO:0006997	1/104	nucleus organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
EOG8K9DSM	GO:0051225	1/104	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG8K9DSM	GO:0007067	1/104	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8K9DSM	GO:0005819	1/104	spindle	cellular_component	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
EOG8PZMMC	GO:0005509	23/104	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8PZMMC	GO:0004725	2/104	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8PZMMC	GO:0007009	1/104	plasma membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8PZMMC	GO:0007274	1/104	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8PZMMC	GO:0051693	1/104	actin filament capping	biological_process	"The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]
EOG8PZMMC	GO:0016323	1/104	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG8PZMMC	GO:0008017	1/104	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8PZMMC	GO:0031594	1/104	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8PZMMC	GO:0048134	1/104	germ-line cyst formation	biological_process	"Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920]
EOG8PZMMC	GO:0045169	1/104	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG8PZMMC	GO:0005938	1/104	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8PZMMC	GO:0007308	1/104	oocyte construction	biological_process	"The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732]
EOG8PZMMC	GO:0005886	1/104	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8PZMMC	GO:0005794	1/104	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8PZMMC	GO:0007294	1/104	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8PZMMC	GO:0005811	1/104	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8PZMMC	GO:0030727	1/104	germarium-derived female germ-line cyst formation	biological_process	"Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902]
EOG8PZMMC	GO:0050807	1/104	regulation of synapse organization	biological_process	"Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]
EOG8PZMMC	GO:0003779	1/104	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8PZMMC	GO:0007417	1/104	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8PZMMC	GO:0048790	1/104	maintenance of presynaptic active zone structure	biological_process	"The process in which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr]
EOG8PZMMC	GO:0045478	1/104	fusome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells." [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah]
EOG8PZMMC	GO:0008360	1/104	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8PZMMC	GO:0030707	1/104	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8PZMMC	GO:0007026	1/104	negative regulation of microtubule depolymerization	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]
EOG8PZMMC	GO:0042062	1/104	long-term strengthening of neuromuscular junction	biological_process	"Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse." [GO_REF:0000021, GOC:mtg_15jun06_goc\:pd]
EOG8PZMMC	GO:0008092	1/104	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8PZMMC	GO:0045170	1/104	spectrosome	cellular_component	"A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf]
EOG8PZMMC	GO:0016199	1/104	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG8PZMMC	GO:0030721	1/104	spectrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome." [PMID:11131529]
EOG8PZMMC	GO:0008091	1/104	spectrin	cellular_component	"Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194]
EOG8K9DSH	GO:0006396	25/98	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8K9DSH	GO:0003723	25/98	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8K9DSH	GO:0004252	1/98	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8Z919S	GO:0005524	27/100	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8Z919S	GO:0004674	21/100	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8Z919S	GO:0004672	5/100	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8Z919S	GO:0035234	1/100	ectopic germ cell programmed cell death	biological_process	"Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944]
EOG8Z919S	GO:0071480	1/100	cellular response to gamma radiation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah]
EOG8Z919S	GO:0006915	1/100	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8Z919S	GO:0006468	1/100	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8Z919S	GO:0000077	1/100	DNA damage checkpoint	biological_process	"A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle]
EOG8Z919S	GO:0005634	1/100	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z919S	GO:0004683	1/100	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG8Z919S	GO:0050321	1/100	tau-protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]
EOG8Z919S	GO:0051091	1/100	positive regulation of sequence-specific DNA binding transcription factor activity	biological_process	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]
EOG8Z919S	GO:0004697	1/100	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG8Z919S	GO:0006974	1/100	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8Z919S	GO:0006919	1/100	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
EOG8Z919S	GO:0045944	1/100	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8Z919S	GO:0072332	1/100	intrinsic apoptotic signaling pathway by p53 class mediator	biological_process	"A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis]
EOG8Z919S	GO:0006282	1/100	regulation of DNA repair	biological_process	"Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators]
EOG8Z919S	GO:0016607	1/100	nuclear speck	cellular_component	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]
EOG8Z919S	GO:0007281	1/100	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8Z919S	GO:0008630	1/100	intrinsic apoptotic signaling pathway in response to DNA damage	biological_process	"A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]
EOG8K9DS4	GO:0008184	26/97	glycogen phosphorylase activity	molecular_function	"Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN]
EOG8K9DS4	GO:0005975	25/97	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8K9DS4	GO:0030170	24/97	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8K9DS4	GO:0050829	1/97	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8K9DS4	GO:0060361	1/97	flight	biological_process	"Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph]
EOG8K9DS4	GO:0005980	1/97	glycogen catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]
EOG8K9DS4	GO:0045824	1/97	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG8DNHJZ	GO:0031012	8/43	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8DNHJZ	GO:0008270	8/43	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DNHJZ	GO:0004222	8/43	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8DNHJZ	GO:0005509	3/43	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8DNHJX	GO:0005524	25/89	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8DNHJX	GO:0004707	20/89	MAP kinase activity	molecular_function	"Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]
EOG8DNHJX	GO:0004674	5/89	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8DNHJX	GO:0004672	2/89	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8DNHJX	GO:0006468	1/89	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8DNHJX	GO:0016651	1/89	oxidoreductase activity, acting on NAD(P)H	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8DNHJX	GO:0016020	1/89	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8DNHJX	GO:0045887	1/89	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8DNHJX	GO:0048749	1/89	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8DNHJX	GO:0030178	1/89	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8DNHJX	GO:0001736	1/89	establishment of planar polarity	biological_process	"Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
EOG8DNHJX	GO:0007474	1/89	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG8DNHJX	GO:0016318	1/89	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG8DNHJX	GO:0008586	1/89	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG8DNHJX	GO:0042332	1/89	gravitaxis	biological_process	"The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
EOG8DNHJX	GO:0007476	1/89	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8DNHJX	GO:0030246	1/89	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8DNHJX	GO:0051539	1/89	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8S4RW3	GO:0005509	3/35	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8Z919X	GO:0008270	22/86	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Z919X	GO:0016787	22/86	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8Z919X	GO:0003824	2/86	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8N06TV	GO:0004047	23/86	aminomethyltransferase activity	molecular_function	"Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10]
EOG8N06TV	GO:0005737	23/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8N06TV	GO:0006546	23/86	glycine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]
EOG8N06TV	GO:0016491	22/86	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8MWBNK	GO:0016788	2/98	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG8MWBNK	GO:0003678	1/98	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8MWBNK	GO:0000723	1/98	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8MWBNK	GO:0006281	1/98	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8MWBNV	GO:0016021	4/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8MWBNV	GO:0005267	4/9	potassium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG80ZTC2	GO:0005267	2/34	potassium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG80ZTC2	GO:0016021	2/34	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DNHJF	GO:0006313	5/111	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG8DNHJF	GO:0003677	5/111	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DNHJF	GO:0004803	5/111	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG8DNHJD	GO:0005507	33/127	copper ion binding	molecular_function	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]
EOG8DNHJD	GO:0016491	31/127	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8DNHJD	GO:0004322	1/127	ferroxidase activity	molecular_function	"Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1]
EOG8DNHJD	GO:0008447	1/127	L-ascorbate oxidase activity	molecular_function	"Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O." [EC:1.10.3.3]
EOG8DNHJD	GO:0031233	1/127	intrinsic component of external side of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah]
EOG8DNHJD	GO:0055072	1/127	iron ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
EOG8DNHJD	GO:0045178	1/127	basal part of cell	cellular_component	"The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194]
EOG8DNHJD	GO:0009986	1/127	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8J9QDG	GO:0016020	20/108	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8J9QDG	GO:0005886	1/108	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8J9QDG	GO:0008039	1/108	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8J9QDC	GO:0016972	54/120	thiol oxidase activity	molecular_function	"Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O." [EC:1.8.3.2]
EOG8J9QDC	GO:0045454	51/120	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8J9QDC	GO:0005615	3/120	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8J9QDC	GO:0032504	3/120	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8J9QDC	GO:0016853	2/120	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8J9QDC	GO:0005576	1/120	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8J9QDC	GO:0046872	1/120	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8J9QDC	GO:0016491	1/120	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG81VNGS	GO:0004642	22/91	phosphoribosylformylglycinamidine synthase activity	molecular_function	"Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate." [EC:6.3.5.3, RHEA:17132]
EOG81VNGS	GO:0006189	22/91	'de novo' IMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]
EOG81VNGS	GO:0003824	2/91	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG81VNGS	GO:0005524	1/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG81VNGS	GO:0006541	1/91	glutamine metabolic process	biological_process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
EOG8X99XQ	GO:0032007	22/81	negative regulation of TOR signaling	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8X99XQ	GO:0048011	22/81	neurotrophin TRK receptor signaling pathway	biological_process	"A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:ceb, GOC:jc, GOC:signaling, PMID:12065629, Wikipedia:Trk_receptor]
EOG8X99XQ	GO:0030178	1/81	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8X99XQ	GO:0048749	1/81	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8X99XQ	GO:0035214	1/81	eye-antennal disc development	biological_process	"Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8X99XQ	GO:0045570	1/81	regulation of imaginal disc growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators]
EOG8X99XQ	GO:0046329	1/81	negative regulation of JNK cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8X99XQ	GO:0038202	1/81	TORC1 signaling	biological_process	"A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]
EOG8X99XQ	GO:0007219	1/81	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8X99XQ	GO:0043069	1/81	negative regulation of programmed cell death	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
EOG8X99XQ	GO:0005737	1/81	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8X99XM	GO:0016021	24/72	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PK4PD	GO:0005524	81/297	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8PK4PD	GO:0004674	77/297	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8PK4PD	GO:0006468	5/297	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8PK4PD	GO:0004683	4/297	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG8PK4PD	GO:0042594	2/297	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8PK4PD	GO:0004672	2/297	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8PK4PD	GO:0045169	1/297	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG8PK4PD	GO:0007015	1/297	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8PK4PD	GO:0031594	1/297	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8PK4PD	GO:0009798	1/297	axis specification	biological_process	"The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete]
EOG8PK4PD	GO:0055088	1/297	lipid homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]
EOG8PK4PD	GO:0061174	1/297	type I terminal bouton	cellular_component	"Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc]
EOG8PK4PD	GO:0007317	1/297	regulation of pole plasm oskar mRNA localization	biological_process	"Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb]
EOG8PK4PD	GO:0019730	1/297	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG8PK4PD	GO:0007318	1/297	pole plasm protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
EOG8PK4PD	GO:0008360	1/297	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8PK4PD	GO:0000226	1/297	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8PK4PD	GO:0030111	1/297	regulation of Wnt signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]
EOG8PK4PD	GO:0007294	1/297	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8PK4PD	GO:0007298	1/297	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8PK4PD	GO:0001737	1/297	establishment of imaginal disc-derived wing hair orientation	biological_process	"Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]
EOG8PK4PD	GO:0005938	1/297	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8PK4PD	GO:0090176	1/297	microtubule cytoskeleton organization involved in establishment of planar polarity	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8PK4PD	GO:0030709	1/297	border follicle cell delamination	biological_process	"The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261]
EOG8PK4PD	GO:0016323	1/297	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG8PK4PD	GO:0009994	1/297	oocyte differentiation	biological_process	"The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu]
EOG8PK4PD	GO:0051663	1/297	oocyte nucleus localization involved in oocyte dorsal/ventral axis specification	biological_process	"The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte." [GOC:ai, GOC:dph, GOC:mtg_sensu, GOC:tb]
EOG8PK4PD	GO:0045451	1/297	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8PK4PD	GO:0045172	1/297	germline ring canal	cellular_component	"Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801]
EOG8PK4PD	GO:0050321	1/297	tau-protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]
EOG8PK4PD	GO:0007314	1/297	oocyte anterior/posterior axis specification	biological_process	"Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8PK4PD	GO:0009948	1/297	anterior/posterior axis specification	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8PK4PD	GO:0045185	1/297	maintenance of protein location	biological_process	"Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf]
EOG8PK4PD	GO:0030707	1/297	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8PK4PD	GO:0051124	1/297	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8PK4PD	GO:0016325	1/297	oocyte microtubule cytoskeleton organization	biological_process	"Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]
EOG8TF301	GO:0004674	26/119	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8TF301	GO:0005524	24/119	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8TF301	GO:0004672	2/119	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8TF301	GO:0032879	1/119	regulation of localization	biological_process	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]
EOG8TF301	GO:0023014	1/119	signal transduction by protein phosphorylation	biological_process	"A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling]
EOG8TF301	GO:0005737	1/119	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8TF301	GO:1990023	1/119	mitotic spindle midzone	cellular_component	"The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner." [GOC:mtg_cell_cycle, GOC:vw]
EOG8TF301	GO:0007052	1/119	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8TF301	GO:0008283	1/119	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8TF301	GO:0010800	1/119	positive regulation of peptidyl-threonine phosphorylation	biological_process	"Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb]
EOG8TF301	GO:0000902	1/119	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8TF301	GO:0004702	1/119	receptor signaling protein serine/threonine kinase activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah]
EOG8TF301	GO:0032154	1/119	cleavage furrow	cellular_component	"In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409]
EOG8TF301	GO:0005938	1/119	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8TF301	GO:0000132	1/119	establishment of mitotic spindle orientation	biological_process	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
EOG8TF301	GO:0033109	1/119	cortical actin cytoskeleton stabilization	biological_process	"The process in which the assembly and arrangement of cytoskeletal structures in the actin cortex with respect to the plasma membrane is maintained." [GOC:mah, GOC:pf]
EOG8TF301	GO:0000281	1/119	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8TF301	GO:0007091	1/119	metaphase/anaphase transition of mitotic cell cycle	biological_process	"The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mtg_cell_cycle, PMID:10465783]
EOG8TF301	GO:0006468	1/119	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8SN45G	GO:0003682	14/229	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8SN45G	GO:0006915	3/229	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8SN45G	GO:0005634	3/229	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SN45G	GO:0003677	3/229	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8SN45G	GO:0008270	1/229	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84N171	GO:0004799	31/106	thymidylate synthase activity	molecular_function	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate." [EC:2.1.1.45, RHEA:12107]
EOG84N171	GO:0006231	31/106	dTMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732]
EOG84N171	GO:0022008	1/106	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84N171	GO:0006235	1/106	dTTP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate." [ISBN:0198506732]
EOG84N172	GO:0008270	1/48	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84N172	GO:0003964	1/48	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG84N172	GO:0003676	1/48	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84N172	GO:0003723	1/48	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8JHFVP	GO:0003924	29/92	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8JHFVP	GO:0005525	29/92	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8JHFVP	GO:0030382	1/92	sperm mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144]
EOG8JHFVP	GO:0005875	1/92	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8JHFVP	GO:0000281	1/92	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8JHFVP	GO:0016185	1/92	synaptic vesicle budding from presynaptic membrane	biological_process	"Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." [GOC:curators, PMID:10099709]
EOG8JHFVP	GO:0090141	1/92	positive regulation of mitochondrial fission	biological_process	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8JHFVP	GO:0007005	1/92	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8JHFVP	GO:0051646	1/92	mitochondrion localization	biological_process	"Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
EOG8X99XB	GO:0016020	29/97	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8X99XB	GO:0016758	29/97	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8X99XB	GO:0005975	29/97	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8JHFVS	GO:0005634	25/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8JHFVS	GO:0006260	25/90	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8JHFVS	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8JHFVS	GO:0070868	1/90	heterochromatin organization involved in chromatin silencing	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah]
EOG8JHFVS	GO:0016321	1/90	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8JHFVS	GO:1901693	1/90	negative regulation of compound eye retinal cell apoptotic process	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]
EOG8JHFVS	GO:0045678	1/90	positive regulation of R7 cell differentiation	biological_process	"Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8JHFVS	GO:0042023	1/90	DNA endoreduplication	biological_process	"Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw]
EOG8JHFVS	GO:0035214	1/90	eye-antennal disc development	biological_process	"Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8JHFVS	GO:0030261	1/90	chromosome condensation	biological_process	"The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8JHFVS	GO:0045931	1/90	positive regulation of mitotic cell cycle	biological_process	"Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8JHFVS	GO:0046872	1/90	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8B8MVT	GO:0003676	7/18	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8B8MVT	GO:0015074	7/18	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8WM7CM	GO:0003777	2/2	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8WM7CM	GO:0001539	2/2	cilium or flagellum-dependent cell motility	biological_process	"Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc]
EOG8WM7CM	GO:0007018	2/2	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8WM7CM	GO:0016887	2/2	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8WM7CM	GO:0005524	2/2	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WM7CM	GO:0030031	2/2	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG83JFKH	GO:0008474	26/91	palmitoyl-(protein) hydrolase activity	molecular_function	"Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22]
EOG83JFKH	GO:0006464	25/91	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG83JFKH	GO:0002084	1/91	protein depalmitoylation	biological_process	"The removal of palymitoyl groups from a lipoprotein." [GOC:hjd]
EOG83JFKH	GO:0005764	1/91	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG83JFKH	GO:0006898	1/91	receptor-mediated endocytosis	biological_process	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
EOG83JFKH	GO:0006897	1/91	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG83JFKH	GO:0008340	1/91	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8V71X1	GO:0004185	56/160	serine-type carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8V71X1	GO:0005576	1/160	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8V71X1	GO:0033227	1/160	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8VDSDZ	GO:0016787	3/15	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8VDSDZ	GO:0016021	1/15	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VDSDZ	GO:0005215	1/15	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8VDSDZ	GO:0047980	1/15	hippurate hydrolase activity	molecular_function	"Catalysis of the reaction: N-benzoylglycine + H(2)O = benzoate + glycine." [EC:3.5.1.32, RHEA:10427]
EOG89KJ5X	GO:0000502	6/81	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG89KJ5X	GO:0003677	1/81	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG89KJ5X	GO:0006974	1/81	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG89KJ5X	GO:0005515	1/81	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8M0HHN	GO:0046872	23/140	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8M0HHN	GO:0005524	12/140	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8M0HHN	GO:0008094	12/140	DNA-dependent ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl]
EOG8M0HHN	GO:0003677	10/140	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8M0HHN	GO:0006259	10/140	DNA metabolic process	biological_process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]
EOG8M0HHN	GO:0003684	2/140	damaged DNA binding	molecular_function	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
EOG8M0HHN	GO:0006281	2/140	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8GTNV8	GO:0003676	34/211	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GTNV8	GO:0008270	27/211	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GTNV8	GO:0015074	11/211	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8GTNV8	GO:0003723	6/211	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8GTNV8	GO:0005198	6/211	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8GTNV8	GO:0005882	6/211	intermediate filament	cellular_component	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
EOG8GTNV8	GO:0003964	6/211	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8GTNV8	GO:0005524	1/211	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8GTNV8	GO:0005737	1/211	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8GTNV8	GO:0004190	1/211	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8GTNV8	GO:0006457	1/211	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8VDSDH	GO:0072686	1/76	mitotic spindle	cellular_component	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
EOG8VDSDH	GO:0005813	1/76	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8TXF7X	GO:0043565	5/14	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8TXF7X	GO:0003700	5/14	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8TXF7X	GO:0005634	3/14	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TXF7X	GO:0006351	3/14	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8GTNV1	GO:0003682	27/110	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8GTNV1	GO:0005634	27/110	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GTNV1	GO:0003677	27/110	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8ZSCJF	GO:0005634	45/168	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZSCJF	GO:0003700	44/168	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8ZSCJF	GO:0007275	41/168	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8ZSCJF	GO:0000976	35/168	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8ZSCJF	GO:0043565	10/168	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8ZSCJF	GO:0007367	3/168	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG8ZSCJF	GO:0048100	2/168	wing disc anterior/posterior pattern formation	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing." [GOC:jid, PMID:10625531]
EOG8ZSCJF	GO:0007386	2/168	compartment pattern specification	biological_process	"The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8ZSCJF	GO:0007474	2/168	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG8ZSCJF	GO:0007400	2/168	neuroblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
EOG8ZSCJF	GO:0003677	2/168	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8ZSCJF	GO:0007388	1/168	posterior compartment specification	biological_process	"The process involved in the specification of cell identity in the posterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8ZSCJF	GO:0000122	1/168	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8ZSCJF	GO:0048099	1/168	anterior/posterior lineage restriction, imaginal disc	biological_process	"Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:jid, PMID:10625531, PMID:9374402]
EOG8ZSCJF	GO:0007487	1/168	analia development	biological_process	"The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu]
EOG8ZSCJF	GO:0007485	1/168	imaginal disc-derived male genitalia development	biological_process	"The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
EOG8ZSCJF	GO:0010629	1/168	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8ZSCJF	GO:0035288	1/168	anterior head segmentation	biological_process	"Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136]
EOG8ZSCJF	GO:0007486	1/168	imaginal disc-derived female genitalia development	biological_process	"The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
EOG8ZSCJF	GO:0035289	1/168	posterior head segmentation	biological_process	"Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136]
EOG8ZSCJF	GO:0007447	1/168	imaginal disc pattern formation	biological_process	"The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid]
EOG8ZSCJF	GO:0045944	1/168	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8ZSCJF	GO:0016787	1/168	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8ZSCJF	GO:0035215	1/168	genital disc development	biological_process	"Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318]
EOG8ZSCJF	GO:0007476	1/168	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8ZSCJF	GO:0035277	1/168	spiracle morphogenesis, open tracheal system	biological_process	"The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268]
EOG8ZSCJF	GO:0050832	1/168	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8ZSCJF	GO:0000980	1/168	RNA polymerase II distal enhancer sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH]
EOG8ZSCJF	GO:0007418	1/168	ventral midline development	biological_process	"The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342]
EOG8ZSCJF	GO:0045892	1/168	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8ZSCJF	GO:0010468	1/168	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8ZSCJF	GO:0008406	1/168	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG8ZSCJF	GO:0035290	1/168	trunk segmentation	biological_process	"Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402]
EOG8ZSCJF	GO:0007411	1/168	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8ZSCJF	GO:0006351	1/168	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8ZSCJF	GO:0007448	1/168	anterior/posterior pattern specification, imaginal disc	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238]
EOG8ZSCJF	GO:0001158	1/168	enhancer sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH]
EOG8ZSCJF	GO:0021960	1/168	anterior commissure morphogenesis	biological_process	"Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
EOG8ZSCJF	GO:0001078	1/168	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
EOG8ZSCJF	GO:0035224	1/168	genital disc anterior/posterior pattern formation	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318]
EOG86X1VD	GO:0003723	1/4	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG86X1VD	GO:0003964	1/4	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG851H5F	GO:0006030	1/20	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG851H5F	GO:0005576	1/20	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG851H5F	GO:0008061	1/20	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG870WX4	GO:0008270	19/108	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG870WX4	GO:0003677	9/108	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG870WX4	GO:0005634	1/108	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG870WX4	GO:0005515	1/108	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG870WX4	GO:0043234	1/108	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG870WX4	GO:0005739	1/108	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG870WX4	GO:0006697	1/108	ecdysone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732]
EOG870WX4	GO:0006355	1/108	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG870WX4	GO:0006357	1/108	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG870WX4	GO:0006310	1/108	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG870WX4	GO:0015074	1/108	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG870WX4	GO:0000792	1/108	heterochromatin	cellular_component	"A compact and highly condensed form of chromatin." [GOC:elh]
EOG870WX4	GO:0051607	1/108	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG870WX4	GO:0004871	1/108	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG870WX4	GO:0005705	1/108	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG870WX4	GO:0000791	1/108	euchromatin	cellular_component	"A dispersed and relatively uncompacted form of chromatin." [GOC:elh]
EOG870WX4	GO:0035012	1/108	polytene chromosome, telomeric region	cellular_component	"The terminal region of a polytene chromosome." [GOC:bf]
EOG870WX4	GO:0022008	1/108	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG870WX4	GO:0016233	1/108	telomere capping	biological_process	"A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055]
EOG870WX3	GO:0007035	1/120	vacuolar acidification	biological_process	"Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid]
EOG870WX3	GO:0008593	1/120	regulation of Notch signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8GTNVG	GO:0016740	1/37	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8M0HH7	GO:0003677	18/140	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8M0HH7	GO:0015074	16/140	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8M0HH7	GO:0006310	16/140	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8M0HH7	GO:0008270	3/140	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8M0HH7	GO:0005634	2/140	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8M0HH7	GO:0003964	2/140	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8M0HH7	GO:0051607	2/140	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG8M0HH7	GO:0005739	2/140	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8M0HH7	GO:0004871	2/140	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8M0HH7	GO:0003723	2/140	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8M0HH7	GO:0005975	1/140	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8M0HH7	GO:0016616	1/140	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8M0HH7	GO:0003676	1/140	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M0HH5	GO:0003677	2/10	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8M0HH5	GO:0003676	1/10	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M0HH4	GO:0030246	43/188	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8JDKQ5	GO:0008052	1/105	sensory organ boundary specification	biological_process	"The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained." [GO_REF:0000021, GOC:mtg_15jun06]
EOG8JDKQ5	GO:0005634	1/105	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8JDKQ5	GO:0048813	1/105	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8JDKQ5	GO:0007423	1/105	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8JDKQ5	GO:0006351	1/105	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8JDKQ5	GO:0046982	1/105	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8JDKQ5	GO:0006355	1/105	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8JDKQ5	GO:0016360	1/105	sensory organ precursor cell fate determination	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
EOG8GTNVW	GO:0005615	233/444	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8GTNVW	GO:0010951	13/444	negative regulation of endopeptidase activity	biological_process	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0004867	13/444	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG8GTNVW	GO:0016740	13/444	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8GTNVW	GO:0030162	12/444	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8GTNVW	GO:0045861	10/444	negative regulation of proteolysis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
EOG8GTNVW	GO:0008233	8/444	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8GTNVW	GO:0032504	7/444	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8GTNVW	GO:0000155	6/444	phosphorelay sensor kinase activity	molecular_function	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
EOG8GTNVW	GO:0016020	6/444	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8GTNVW	GO:0019732	1/444	antifungal humoral response	biological_process	"An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8GTNVW	GO:0008063	1/444	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8GTNVW	GO:0002784	1/444	regulation of antimicrobial peptide production	biological_process	"Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
EOG8GTNVW	GO:0003677	1/444	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GTNVW	GO:0005576	1/444	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8GTNVW	GO:0006281	1/444	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8GTNVW	GO:0050829	1/444	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GTNVW	GO:0060570	1/444	negative regulation of peptide hormone processing	biological_process	"Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0006955	1/444	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8GTNVW	GO:0004869	1/444	cysteine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0010955	1/444	negative regulation of protein processing	biological_process	"Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]
EOG8GTNVW	GO:0042562	1/444	hormone binding	molecular_function	"Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
EOG8GTNVW	GO:0045751	1/444	negative regulation of Toll signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8GTNVW	GO:0050832	1/444	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8W3W3R	GO:0005975	2/3	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8W3W3R	GO:0004553	2/3	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG83JFK9	GO:0006544	28/99	glycine metabolic process	biological_process	"The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators]
EOG83JFK9	GO:0006563	28/99	L-serine metabolic process	biological_process	"The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg]
EOG83JFK9	GO:0030170	28/99	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG83JFK9	GO:0004372	28/99	glycine hydroxymethyltransferase activity	molecular_function	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1]
EOG83JFK9	GO:0035999	25/99	tetrahydrofolate interconversion	biological_process	"The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999, UniPathway:UPA00193]
EOG83JFK9	GO:0008168	7/99	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG83JFK9	GO:0048149	1/99	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG837TVT	GO:0003676	21/93	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG837TVT	GO:0071011	1/93	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG837TVT	GO:0000398	1/93	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG837TVT	GO:0005634	1/93	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG837TVT	GO:0030529	1/93	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG837TVT	GO:0019013	1/93	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG86Q97F	GO:0005524	2/10	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG86Q97F	GO:0004326	1/10	tetrahydrofolylpolyglutamate synthase activity	molecular_function	"Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17]
EOG86Q97F	GO:0016874	1/10	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG86Q97F	GO:0009058	1/10	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG837TVZ	GO:0036064	1/93	ciliary basal body	cellular_component	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]
EOG837TVZ	GO:0006919	1/93	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
EOG837TVZ	GO:0005737	1/93	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG837TVZ	GO:0006915	1/93	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG837TVZ	GO:0042981	1/93	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG837TVZ	GO:0042384	1/93	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8GJ25H	GO:0008270	22/86	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GJ25H	GO:0003677	19/86	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG83JFK2	GO:0016772	13/83	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG83JFK2	GO:0003676	2/83	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83JFK2	GO:0046872	1/83	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8M0HFJ	GO:0042052	1/100	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8M0HFJ	GO:0050896	1/100	response to stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
EOG8M0HFJ	GO:0007156	1/100	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8M0HFJ	GO:0007601	1/100	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8M0HFJ	GO:0035996	1/100	rhabdomere microvillus	cellular_component	"Thin cylindrical membrane-covered projection on the surface of a rhabdomere." [GOC:bf, GOC:sart, PMID:14744998]
EOG8M0HFJ	GO:0046658	1/100	anchored component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG8M0HFJ	GO:0004721	1/100	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8M0HFJ	GO:0005886	1/100	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8M0HFJ	GO:0016028	1/100	rhabdomere	cellular_component	"The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774]
EOG8616M6	GO:0008270	4/65	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8616M6	GO:0003676	3/65	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8616M6	GO:0003723	1/65	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8616M6	GO:0003964	1/65	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8VQD44	GO:0020037	27/145	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8VQD44	GO:0005506	27/145	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8VQD44	GO:0016705	25/145	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8VQD44	GO:0051205	23/145	protein insertion into membrane	biological_process	"The process that results in the incorporation of a protein into a biological membrane.  Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]
EOG8VQD44	GO:0016021	23/145	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VQD44	GO:0004497	22/145	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8VQD44	GO:0005576	2/145	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8VQD44	GO:0008061	2/145	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8VQD44	GO:0006030	2/145	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8VQD44	GO:0008386	2/145	cholesterol monooxygenase (side-chain-cleaving) activity	molecular_function	"Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6]
EOG8VQD44	GO:0005272	1/145	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8VQD44	GO:0042768	1/145	ecdysteroid 2-hydroxylase activity	molecular_function	"Catalysis of the hydroxylation of an ecdysteroid at carbon position 2." [PMID:12177427]
EOG8VQD44	GO:0031966	1/145	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG8VQD44	GO:0007391	1/145	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8VQD44	GO:0007417	1/145	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8VQD44	GO:0008045	1/145	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8VQD44	GO:0006697	1/145	ecdysone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732]
EOG8VQD44	GO:0007494	1/145	midgut development	biological_process	"The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
EOG8VQD44	GO:0008258	1/145	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8VQD44	GO:0005739	1/145	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8M0HFS	GO:0030170	10/82	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8M0HFS	GO:0003824	10/82	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8M0HFR	GO:0015012	30/101	heparan sulfate proteoglycan biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210]
EOG8M0HFR	GO:0031227	24/101	intrinsic component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
EOG8M0HFR	GO:0016758	21/101	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8M0HFR	GO:0005783	7/101	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8M0HFR	GO:0050508	4/101	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP." [EC:2.4.1.224, MetaCyc:2.4.1.224-RXN]
EOG8M0HFR	GO:0048488	1/101	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8M0HFR	GO:0008375	1/101	acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]
EOG8M0HFR	GO:0000139	1/101	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8M0HFR	GO:0015020	1/101	glucuronosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17]
EOG8M0HFR	GO:0015014	1/101	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan." [GOC:ai]
EOG8M0HFR	GO:0005515	1/101	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8M0HFR	GO:0016021	1/101	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M0HFR	GO:0050509	1/101	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	molecular_function	"Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.225, MetaCyc:2.4.1.225-RXN]
EOG8M0HFR	GO:0016055	1/101	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG8M0HFR	GO:0048312	1/101	intracellular distribution of mitochondria	biological_process	"Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid]
EOG8M0HFR	GO:0006024	1/101	glycosaminoglycan biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]
EOG8M0HFR	GO:0008589	1/101	regulation of smoothened signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG8M0HFR	GO:0006486	1/101	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8M0HFR	GO:0030210	1/101	heparin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732]
EOG8M0HFR	GO:0006044	1/101	N-acetylglucosamine metabolic process	biological_process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
EOG8M0HFR	GO:0008354	1/101	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8M0HFR	GO:0007411	1/101	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8M0HFR	GO:0050808	1/101	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG8M0HFR	GO:0007224	1/101	smoothened signaling pathway	biological_process	"A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
EOG8M0HFR	GO:0005794	1/101	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8M0HFR	GO:0008101	1/101	decapentaplegic signaling pathway	biological_process	"A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:sart, PMID:17428827]
EOG8M0HFW	GO:0046872	24/91	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8M0HFW	GO:0000285	1/91	1-phosphatidylinositol-3-phosphate 5-kinase activity	molecular_function	"Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13612]
EOG8M0HFW	GO:0016020	1/91	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8M0HFW	GO:0009405	1/91	pathogenesis	biological_process	"The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators]
EOG8K0T37	GO:0032440	2/112	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8K0T37	GO:0004190	1/112	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8B5RMC	GO:0046872	1/75	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG883GJH	GO:0031932	27/100	TORC2 complex	cellular_component	"A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787]
EOG883GJH	GO:0031929	27/100	TOR signaling	biological_process	"A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]
EOG883GJH	GO:0048813	1/100	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG883GJH	GO:0006974	1/100	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG883GJH	GO:0051124	1/100	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8RNDQD	GO:0016021	3/27	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RNDQD	GO:0005216	3/27	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG883GJG	GO:0005524	30/126	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG883GJG	GO:0003676	29/126	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG883GJG	GO:0008026	27/126	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG883GJG	GO:0004386	3/126	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG883GJG	GO:0008152	1/126	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG883GJG	GO:0006200	1/126	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG883GJG	GO:0002151	1/126	G-quadruplex RNA binding	molecular_function	"Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad." [PMID:18294969, PMID:18568163, PMID:19330720]
EOG883GJG	GO:0004004	1/126	ATP-dependent RNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]
EOG886BTT	GO:0003676	4/9	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG886BTT	GO:0005634	3/9	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG886BTT	GO:0008270	3/9	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG886BTT	GO:0046872	1/9	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG886BTR	GO:0007094	28/96	mitotic spindle assembly checkpoint	biological_process	"A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190]
EOG886BTR	GO:0005828	1/96	kinetochore microtubule	cellular_component	"Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194]
EOG886BTR	GO:0072686	1/96	mitotic spindle	cellular_component	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
EOG886BTR	GO:0005737	1/96	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG886BTR	GO:0000776	1/96	kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG886BTR	GO:0007346	1/96	regulation of mitotic cell cycle	biological_process	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG886BTR	GO:0005635	1/96	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG886BTR	GO:1990047	1/96	spindle matrix	cellular_component	"A proteinaceous, nuclear-derived structure that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner during mitosis." [GOC:ans, PMID:19273613, PMID:22855526]
EOG886BTR	GO:1901673	1/96	regulation of mitotic spindle assembly	biological_process	"Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie]
EOG886BTR	GO:0005819	1/96	spindle	cellular_component	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
EOG886BTR	GO:0000278	1/96	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG886BTR	GO:0005654	1/96	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG886BTR	GO:0090231	1/96	regulation of spindle checkpoint	biological_process	"Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG886BTR	GO:0005875	1/96	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG886BTR	GO:0005634	1/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG886BTR	GO:0005515	1/96	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8W6R8R	GO:0016021	2/114	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W6R8R	GO:0050808	1/114	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG8W6R8R	GO:0051124	1/114	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8W6R8R	GO:0007155	1/114	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8W6R8R	GO:0045211	1/114	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8W6R8R	GO:0043005	1/114	neuron projection	cellular_component	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
EOG8W6R8R	GO:0016200	1/114	synaptic target attraction	biological_process	"The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437]
EOG8W6R8R	GO:0034116	1/114	positive regulation of heterotypic cell-cell adhesion	biological_process	"Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add]
EOG8W6R8R	GO:0031005	1/114	filamin binding	molecular_function	"Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain." [GOC:mah, PMID:11336782]
EOG8W6R8R	GO:0005515	1/114	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8W6R8R	GO:0042802	1/114	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG8W6R8R	GO:0097090	1/114	presynaptic membrane organization	biological_process	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction." [GOC:BHF, GOC:pr, GOC:sjp, PMID:19730411]
EOG8W6R8R	GO:0043025	1/114	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8W6R8R	GO:0042051	1/114	compound eye photoreceptor development	biological_process	"The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
EOG8W6R8R	GO:0046982	1/114	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8W6R8R	GO:0005887	1/114	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W6R8R	GO:0005578	1/114	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG8W6R8R	GO:0048499	1/114	synaptic vesicle membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle." [GOC:dph, GOC:jl, GOC:mah, PMID:10620806]
EOG8W6R8R	GO:0048790	1/114	maintenance of presynaptic active zone structure	biological_process	"The process in which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr]
EOG8W6R8R	GO:0005737	1/114	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8W6R8R	GO:0001941	1/114	postsynaptic membrane organization	biological_process	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph, GOC:pr]
EOG8W6R8R	GO:0008045	1/114	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8W6R8R	GO:0045467	1/114	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8W6R8R	GO:0031122	1/114	cytoplasmic microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
EOG8W6R8R	GO:2000331	1/114	regulation of terminal button organization	biological_process	"Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah]
EOG8W6R8R	GO:0001745	1/114	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8W6R8R	GO:0048058	1/114	compound eye corneal lens development	biological_process	"The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells." [GOC:jid]
EOG8W6R8R	GO:0008360	1/114	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8W6R8R	GO:0022416	1/114	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8W6R8R	GO:0030054	1/114	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8W6R8R	GO:0007274	1/114	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8W6R8R	GO:0008039	1/114	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8W6R8R	GO:0042803	1/114	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8W6R8R	GO:0040017	1/114	positive regulation of locomotion	biological_process	"Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]
EOG8W6R8R	GO:0031594	1/114	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8W6R8R	GO:0004714	1/114	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8W6R8R	GO:0034110	1/114	regulation of homotypic cell-cell adhesion	biological_process	"Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add]
EOG886BTJ	GO:0005524	22/171	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG886BTJ	GO:0035091	22/171	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG886BTJ	GO:0004672	21/171	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG886BTJ	GO:0005635	1/171	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG886BTJ	GO:0048477	1/171	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG886BTJ	GO:0043234	1/171	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG886BTJ	GO:0016772	1/171	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG886BTJ	GO:0016301	1/171	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG886BTJ	GO:0051445	1/171	regulation of meiotic cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG886BTJ	GO:0007346	1/171	regulation of mitotic cell cycle	biological_process	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8TQPQG	GO:0003723	24/91	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8TQPQG	GO:0007616	1/91	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8TQPQG	GO:0097482	1/91	muscle cell postsynaptic density	cellular_component	"A postsynaptic density that is part of a muscle cell." [GOC:pr]
EOG8TQPQG	GO:0001709	1/91	cell fate determination	biological_process	"A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
EOG8TQPQG	GO:0008258	1/91	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8TQPQG	GO:0016477	1/91	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG8TQPQG	GO:0045892	1/91	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8TQPQG	GO:0048813	1/91	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8TQPQG	GO:0031594	1/91	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8TQPQG	GO:0007067	1/91	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8TQPQG	GO:0005635	1/91	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG8TQPQG	GO:0007268	1/91	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8TQPQG	GO:0007280	1/91	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG8TQPQG	GO:0045786	1/91	negative regulation of cell cycle	biological_process	"Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8TQPQG	GO:0048477	1/91	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8TQPQG	GO:0005737	1/91	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8TQPQG	GO:0007281	1/91	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8TQPQG	GO:0003730	1/91	mRNA 3'-UTR binding	molecular_function	"Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah]
EOG8TQPQG	GO:0008595	1/91	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8TQPQG	GO:0061176	1/91	type Ib terminal bouton	cellular_component	"Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons." [GOC:dph, GOC:mc]
EOG8TQPQG	GO:0061177	1/91	type Is terminal bouton	cellular_component	"Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons." [GOC:dph, GOC:mc]
EOG8TQPQG	GO:0000900	1/91	translation repressor activity, nucleic acid binding	molecular_function	"Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw]
EOG8TQPQG	GO:0008582	1/91	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8TQPQG	GO:0000288	1/91	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	biological_process	"A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc]
EOG8TQPQG	GO:0050804	1/91	modulation of synaptic transmission	biological_process	"Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
EOG8TQPQG	GO:0042078	1/91	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG8TQPQG	GO:0017148	1/91	negative regulation of translation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8TQPQG	GO:0042059	1/91	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8TQPQG	GO:0048149	1/91	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8TQPQG	GO:0045727	1/91	positive regulation of translation	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb]
EOG886BTH	GO:0016021	56/247	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG886BTH	GO:0055085	55/247	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG886BTH	GO:0005743	55/247	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG886BTH	GO:0005215	54/247	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG886BTH	GO:0031532	24/247	actin cytoskeleton reorganization	biological_process	"A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]
EOG886BTH	GO:0007155	24/247	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG886BTH	GO:0005811	2/247	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG886BTH	GO:0009612	1/247	response to mechanical stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]
EOG886BTH	GO:0034599	1/247	cellular response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
EOG886BTH	GO:0007268	1/247	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG886BTH	GO:0040011	1/247	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG886BTH	GO:0051480	1/247	cytosolic calcium ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]
EOG886BTH	GO:0007475	1/247	apposition of dorsal and ventral imaginal disc-derived wing surfaces	biological_process	"The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu]
EOG886BTH	GO:0015866	1/247	ADP transport	biological_process	"The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG886BTH	GO:0005471	1/247	ATP:ADP antiporter activity	molecular_function	"Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1]
EOG886BTH	GO:0005925	1/247	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG886BTH	GO:0051560	1/247	mitochondrial calcium ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah]
EOG886BTH	GO:0006839	1/247	mitochondrial transport	biological_process	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]
EOG886BTH	GO:0008340	1/247	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG886BTH	GO:0015867	1/247	ATP transport	biological_process	"The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG886BTH	GO:0007629	1/247	flight behavior	biological_process	"The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
EOG886BTH	GO:0070050	1/247	neuron cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah]
EOG886BTH	GO:0048489	1/247	synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr]
EOG886BTH	GO:0016203	1/247	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG886BTH	GO:0003779	1/247	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG886BTH	GO:0051124	1/247	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG886BTH	GO:0001508	1/247	action potential	biological_process	"A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]
EOG886BTH	GO:0046716	1/247	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG886BTF	GO:0070403	23/91	NAD+ binding	molecular_function	"Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
EOG886BTF	GO:0006476	20/91	protein deacetylation	biological_process	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]
EOG886BTF	GO:0008270	20/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG886BTF	GO:0016811	19/91	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]
EOG886BTF	GO:0048813	1/91	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG886BTF	GO:0016575	1/91	histone deacetylation	biological_process	"The modification of histones by removal of acetyl groups." [GOC:ai]
EOG886BTF	GO:0008340	1/91	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG886BTF	GO:0017136	1/91	NAD-dependent histone deacetylase activity	molecular_function	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone." [EC:3.5.1.17, RHEA:24551]
EOG886BTD	GO:0008270	4/40	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG886BTD	GO:0003676	4/40	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89360S	GO:0008270	3/41	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG89360S	GO:0003676	3/41	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JT2KW	GO:0004828	27/111	serine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11]
EOG8JT2KW	GO:0005737	27/111	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8JT2KW	GO:0005524	27/111	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8JT2KW	GO:0006434	27/111	seryl-tRNA aminoacylation	biological_process	"The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8TQPQ3	GO:0006139	4/47	nucleobase-containing compound metabolic process	biological_process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
EOG8TQPQ3	GO:0005524	4/47	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8TQPQ3	GO:0019205	4/47	nucleobase-containing compound kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]
EOG8TQPQ3	GO:0017111	1/47	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8TQPQ1	GO:0005622	38/108	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8TQPQ1	GO:0005085	38/108	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8TQPQ1	GO:0007264	38/108	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8TQPQ1	GO:0051056	32/108	regulation of small GTPase mediated signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
EOG8TQPQ1	GO:0016319	1/108	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8TQPQ1	GO:0008360	1/108	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG83V288	GO:0005509	2/236	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG83V288	GO:0005524	1/236	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG83V288	GO:0004674	1/236	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG83V288	GO:0043025	1/236	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG83V288	GO:0042803	1/236	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG83V288	GO:0007422	1/236	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG83V288	GO:0030424	1/236	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG83V288	GO:0021551	1/236	central nervous system morphogenesis	biological_process	"The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089]
EOG83V288	GO:0005887	1/236	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83V288	GO:0032490	1/236	detection of molecule of bacterial origin	biological_process	"The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal." [GOC:add, GOC:rl]
EOG83V288	GO:0016319	1/236	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG83V288	GO:0007419	1/236	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG83V288	GO:0042802	1/236	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG83V288	GO:0050976	1/236	detection of mechanical stimulus involved in sensory perception of touch	biological_process	"The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
EOG83V288	GO:0016020	1/236	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG83V288	GO:0006909	1/236	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG83V288	GO:0030425	1/236	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG83V288	GO:0008046	1/236	axon guidance receptor activity	molecular_function	"Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance." [GOC:dph, GOC:signaling, GOC:tb, PMID:15107857, PMID:15339666]
EOG83V288	GO:0048666	1/236	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG83V288	GO:0007411	1/236	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG83V288	GO:0003823	1/236	antigen binding	molecular_function	"Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732, ISBN:0721662544]
EOG83V288	GO:0050770	1/236	regulation of axonogenesis	biological_process	"Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]
EOG83V288	GO:0007413	1/236	axonal fasciculation	biological_process	"The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh]
EOG83V288	GO:0007156	1/236	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG83V288	GO:0048814	1/236	regulation of dendrite morphogenesis	biological_process	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG83V288	GO:0070593	1/236	dendrite self-avoidance	biological_process	"The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551]
EOG83V288	GO:0043005	1/236	neuron projection	cellular_component	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
EOG83V288	GO:0048846	1/236	axon extension involved in axon guidance	biological_process	"The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jid]
EOG886BT8	GO:0016772	2/29	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8TQPQ5	GO:0016772	2/16	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8TQPQ5	GO:0016310	2/16	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG886BT3	GO:0016021	44/166	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG886BT3	GO:0004930	37/166	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG886BT3	GO:0050254	5/166	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG886BT3	GO:0005000	4/166	vasopressin receptor activity	molecular_function	"Combining with vasopressin to initiate a change in cell activity." [GOC:ai]
EOG886BT3	GO:0016500	3/166	protein-hormone receptor activity	molecular_function	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]
EOG886BT3	GO:0055088	1/166	lipid homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]
EOG886BT3	GO:0070328	1/166	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG886BT3	GO:0016042	1/166	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG886BT3	GO:0097004	1/166	adipokinetic hormone binding	molecular_function	"Interacting selectively and non-covalently with an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407]
EOG886BT3	GO:0097003	1/166	adipokinetic hormone receptor activity	molecular_function	"Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407]
EOG886BT3	GO:0033500	1/166	carbohydrate homeostasis	biological_process	"A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah]
EOG886BT3	GO:0005887	1/166	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG886BT3	GO:0007218	1/166	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG886BT3	GO:0008188	1/166	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG886BT3	GO:0007186	1/166	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8JT2KD	GO:0005086	25/108	ARF guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8JT2KD	GO:0032012	24/108	regulation of ARF protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]
EOG8JT2KD	GO:0032940	1/108	secretion by cell	biological_process	"The controlled release of a substance by a cell." [GOC:mah]
EOG8JT2KD	GO:0000137	1/108	Golgi cis cisterna	cellular_component	"The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194]
EOG8JT2KD	GO:0009306	1/108	protein secretion	biological_process	"The controlled release of proteins from a cell." [GOC:ai]
EOG8JT2KD	GO:0000902	1/108	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8JT2KD	GO:0005801	1/108	cis-Golgi network	cellular_component	"The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]
EOG8JT2KD	GO:0007431	1/108	salivary gland development	biological_process	"The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044]
EOG8JT2KD	GO:0035149	1/108	lumen formation, open tracheal system	biological_process	"Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
EOG8JT2KD	GO:0002064	1/108	epithelial cell development	biological_process	"The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
EOG8JT2KD	GO:0006909	1/108	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8JT2KD	GO:0032312	1/108	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8JT2KD	GO:0007030	1/108	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8JT2KD	GO:0035158	1/108	regulation of tube diameter, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584]
EOG8JT2KB	GO:0005525	1/37	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8JT2KB	GO:0007264	1/37	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8PZMQM	GO:0005742	22/54	mitochondrial outer membrane translocase complex	cellular_component	"A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629]
EOG8PZMQM	GO:0030150	22/54	protein import into mitochondrial matrix	biological_process	"The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]
EOG844P2Q	GO:0005787	24/74	signal peptidase complex	cellular_component	"A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509]
EOG844P2Q	GO:0016021	24/74	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG844P2Q	GO:0008233	24/74	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG844P2Q	GO:0006465	24/74	signal peptide processing	biological_process	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]
EOG84BDFZ	GO:0004867	27/131	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG84BDFZ	GO:0004222	25/131	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG84BDFZ	GO:0008270	24/131	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84BDFZ	GO:0005578	23/131	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG84BDFZ	GO:0005576	3/131	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG84BDFZ	GO:0006030	3/131	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG84BDFZ	GO:0008061	3/131	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG84BDFZ	GO:0008233	2/131	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG84BDFZ	GO:0005201	1/131	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG84BDFZ	GO:0031012	1/131	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG84BDFZ	GO:0005604	1/131	basement membrane	cellular_component	"A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]
EOG84BDFZ	GO:0030198	1/131	extracellular matrix organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]
EOG84BDFZ	GO:0007275	1/131	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8K0T3V	GO:0043565	25/78	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8K0T3V	GO:0004521	1/78	endoribonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8K0T3V	GO:0005737	1/78	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8K0T3V	GO:0090502	1/78	RNA phosphodiester bond hydrolysis, endonucleolytic	biological_process	"The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
EOG8QNQ99	GO:0008286	1/92	insulin receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]
EOG8QNQ99	GO:0005886	1/92	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8QNQ99	GO:0030730	1/92	sequestering of triglyceride	biological_process	"The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:mah, ISBN:0198506732]
EOG8QNQ99	GO:0007398	1/92	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG8QNQ99	GO:0007422	1/92	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8QNQ99	GO:0006629	1/92	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8QNQ99	GO:0035091	1/92	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG8QNQ99	GO:2001020	1/92	regulation of response to DNA damage stimulus	biological_process	"Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
EOG8QNQ99	GO:0045464	1/92	R8 cell fate specification	biological_process	"The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [PMID:11880339]
EOG8QNQ99	GO:0008152	1/92	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8QNQ99	GO:0010314	1/92	phosphatidylinositol-5-phosphate binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position." [GOC:bf, GOC:tair_curators]
EOG8QNQ99	GO:0005515	1/92	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QNQ99	GO:0001708	1/92	cell fate specification	biological_process	"The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators]
EOG8NS5V3	GO:0030154	5/82	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8NS5V3	GO:0007548	5/82	sex differentiation	biological_process	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]
EOG8CC6GF	GO:0000166	26/93	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8CC6GF	GO:0003676	25/93	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CC6GF	GO:0003729	1/93	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8CC6GF	GO:0005875	1/93	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8H1DBQ	GO:0008270	3/25	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8H1DBQ	GO:0003676	3/25	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8H1DBQ	GO:0004190	1/25	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8S4RWK	GO:0016798	25/117	hydrolase activity, acting on glycosyl bonds	molecular_function	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]
EOG8S4RWK	GO:0016020	25/117	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8S4RWK	GO:0005975	4/117	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8S4RWK	GO:0015991	2/117	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8S4RWK	GO:0015078	2/117	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG8S4RWK	GO:0033179	2/117	proton-transporting V-type ATPase, V0 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG8S4RWK	GO:0005811	1/117	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8RNDPR	GO:0016787	2/90	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8RNDPR	GO:0005576	1/90	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8RNDPR	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8RNDPR	GO:0007155	1/90	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8RNDPR	GO:0005840	1/90	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8RNDPR	GO:0008039	1/90	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8RNDPR	GO:0016020	1/90	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8KM1JP	GO:0006281	1/52	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8KM1JP	GO:0000723	1/52	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8KM1JP	GO:0003678	1/52	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8RNDPZ	GO:0016757	23/101	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8RNDPZ	GO:0008466	4/101	glycogenin glucosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin." [EC:2.4.1.186]
EOG82FW0K	GO:0016740	9/186	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG82FW0K	GO:0004364	2/186	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG82FW0K	GO:0005811	1/186	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG82FW0K	GO:0050220	1/186	prostaglandin-E synthase activity	molecular_function	"Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)." [EC:5.3.99.3, RHEA:12896]
EOG8RNDPG	GO:0016620	60/211	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG8RNDPG	GO:0001758	5/211	retinal dehydrogenase activity	molecular_function	"Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36]
EOG8RNDPG	GO:0004029	2/211	aldehyde dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]
EOG8RNDPG	GO:0045471	1/211	response to ethanol	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators]
EOG8RNDPG	GO:0008774	1/211	acetaldehyde dehydrogenase (acetylating) activity	molecular_function	"Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+." [EC:1.2.1.10]
EOG8RNDPG	GO:0005811	1/211	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8RNDPG	GO:0005739	1/211	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8RNDPG	GO:0005737	1/211	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RNDPB	GO:0016021	38/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RNDPB	GO:0008270	1/99	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KM1JB	GO:0048488	26/87	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8KM1JB	GO:0005262	26/87	calcium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8KM1JB	GO:0030285	26/87	integral component of synaptic vesicle membrane	cellular_component	"The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KM1JB	GO:0046530	11/87	photoreceptor cell differentiation	biological_process	"The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732]
EOG8KM1JB	GO:0030054	11/87	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8KM1JB	GO:0044214	1/87	spanning component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:ecd]
EOG8KM1JB	GO:0042802	1/87	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG8KM1JB	GO:0042981	1/87	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8KM1JB	GO:0016021	1/87	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G1PX0	GO:0019799	41/109	tubulin N-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine." [EC:2.3.1.108]
EOG8G1PX0	GO:0071929	41/109	alpha-tubulin acetylation	biological_process	"The addition of an acetyl group to the lysine 40 residue of alpha-tubulin." [GOC:kmv, PMID:17786050]
EOG8G1PX0	GO:0070507	35/109	regulation of microtubule cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8G1PX0	GO:0048666	35/109	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8G1PX0	GO:0048149	1/109	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8RNDP7	GO:0051297	1/68	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8RNDP7	GO:0005874	1/68	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8RNDP7	GO:0000226	1/68	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8RNDP7	GO:0007051	1/68	spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:mah]
EOG8RNDP7	GO:0030723	1/68	ovarian fusome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]
EOG8RNDP7	GO:0051295	1/68	establishment of meiotic spindle localization	biological_process	"The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs." [GOC:ai]
EOG8RNDP7	GO:0007282	1/68	cystoblast division	biological_process	"Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells." [PMID:21452446]
EOG8RNDP7	GO:0007052	1/68	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8RNDP7	GO:0005815	1/68	microtubule organizing center	cellular_component	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416]
EOG8RNDP7	GO:0007017	1/68	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8RNDP7	GO:0005737	1/68	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RNDP7	GO:0048854	1/68	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG8RNDP7	GO:0051383	1/68	kinetochore organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8RNDP7	GO:0007097	1/68	nuclear migration	biological_process	"The directed movement of the nucleus." [GOC:ai]
EOG8RNDP7	GO:0048477	1/68	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8RNDP7	GO:0030037	1/68	actin filament reorganization involved in cell cycle	biological_process	"The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah]
EOG8RNDP7	GO:0007067	1/68	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8RNDP7	GO:0008017	1/68	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8RNDP7	GO:0030954	1/68	astral microtubule nucleation	biological_process	"The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule." [GOC:mah]
EOG8RNDP7	GO:0005813	1/68	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8RNDP7	GO:0030706	1/68	germarium-derived oocyte differentiation	biological_process	"The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8RNDP7	GO:0005634	1/68	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RNDP7	GO:0000922	1/68	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8RNDP7	GO:0005875	1/68	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8RNDP7	GO:0000132	1/68	establishment of mitotic spindle orientation	biological_process	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
EOG8RNDP7	GO:0032027	1/68	myosin light chain binding	molecular_function	"Interacting selectively and non-covalently with a light chain of a myosin complex." [GOC:mah]
EOG8RNDP7	GO:0048132	1/68	female germ-line stem cell asymmetric division	biological_process	"The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu]
EOG8RNDP7	GO:0051642	1/68	centrosome localization	biological_process	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
EOG8WDGSM	GO:0016021	59/151	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WDGSM	GO:0006810	36/151	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8WDGSM	GO:0005215	25/151	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8WDGSM	GO:0005622	25/151	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8WDGSM	GO:0006486	1/151	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8WDGSM	GO:0016787	1/151	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8WDGSM	GO:0008378	1/151	galactosyltransferase activity	molecular_function	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]
EOG8WDGSM	GO:0005794	1/151	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8WDGSC	GO:0008270	13/50	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WDGSB	GO:0008270	56/160	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RNDP9	GO:0007076	28/105	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8RNDP9	GO:0000796	28/105	condensin complex	cellular_component	"A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
EOG8RNDP9	GO:0005524	24/105	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8RNDP9	GO:0006310	21/105	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8RNDP9	GO:0006281	21/105	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8RNDP9	GO:0005634	19/105	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RNDP9	GO:0016491	1/105	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8RNDP9	GO:0022008	1/105	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8RNDP9	GO:0000785	1/105	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG8RNDP9	GO:0007067	1/105	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8RNDP9	GO:0005875	1/105	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8RNDP9	GO:0007052	1/105	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8RNDP9	GO:0005737	1/105	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8M947F	GO:0005975	32/195	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8M947F	GO:0004553	32/195	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8M947F	GO:0045088	1/195	regulation of innate immune response	biological_process	"Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8M947F	GO:0032491	1/195	detection of molecule of fungal origin	biological_process	"The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal." [GOC:mah, GOC:rl]
EOG8M947F	GO:0009986	1/195	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8M947F	GO:0002758	1/195	innate immune response-activating signal transduction	biological_process	"The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8M947F	GO:0045087	1/195	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8M947F	GO:0002221	1/195	pattern recognition receptor signaling pathway	biological_process	"Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
EOG8M947F	GO:0051607	1/195	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG8M947F	GO:0008329	1/195	signaling pattern recognition receptor activity	molecular_function	"Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity." [GOC:ar, PMID:12507420, PMID:12925128, PMID:14523544, Wikipedia:Pattern_recognition_receptor]
EOG8M947F	GO:0001872	1/195	(1->3)-beta-D-glucan binding	molecular_function	"Interacting selectively and non-covalently with (1->3)-beta-D-glucans." [PMID:14707091]
EOG8M947F	GO:0009620	1/195	response to fungus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
EOG8M947F	GO:0005576	1/195	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8W6R95	GO:0003924	29/112	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8W6R95	GO:0005525	29/112	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8W6R95	GO:0005783	2/112	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8W6R95	GO:0007030	1/112	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8W6R95	GO:0016021	1/112	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W6R95	GO:0005509	1/112	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8W6R95	GO:0005515	1/112	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8W6R95	GO:0007528	1/112	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8W6R95	GO:0042802	1/112	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG8W6R95	GO:0016320	1/112	endoplasmic reticulum membrane fusion	biological_process	"The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum." [GOC:elh, GOC:jid]
EOG8W6R95	GO:0016020	1/112	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8W6R95	GO:0042803	1/112	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8W6R95	GO:0006184	1/112	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8W6R95	GO:0000139	1/112	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8W6R95	GO:0031227	1/112	intrinsic component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
EOG8W6R95	GO:0007517	1/112	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8W6R95	GO:0061025	1/112	membrane fusion	biological_process	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]
EOG8W6R95	GO:0007029	1/112	endoplasmic reticulum organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
EOG8W6R95	GO:0051124	1/112	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8W6R95	GO:0006457	1/112	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8W6R95	GO:0008582	1/112	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8W6R95	GO:0032561	1/112	guanyl ribonucleotide binding	molecular_function	"Interacting selectively and non-covalently with a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
EOG8W6R95	GO:0005794	1/112	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8W6R95	GO:0007019	1/112	microtubule depolymerization	biological_process	"The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194]
EOG8W6R95	GO:0005737	1/112	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8W6R95	GO:0051260	1/112	protein homooligomerization	biological_process	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
EOG8W6R95	GO:0031114	1/112	regulation of microtubule depolymerization	biological_process	"Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah]
EOG8PK4Q1	GO:0003676	4/37	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8PK4Q1	GO:0008270	4/37	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PK4Q1	GO:0005634	4/37	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PK4Q1	GO:0046872	1/37	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80GG4W	GO:0031227	25/83	intrinsic component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
EOG80GG4W	GO:0016758	23/83	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG80GG4W	GO:0030210	1/83	heparin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732]
EOG80GG4W	GO:0006044	1/83	N-acetylglucosamine metabolic process	biological_process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
EOG80GG4W	GO:0007275	1/83	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG80GG4W	GO:0007224	1/83	smoothened signaling pathway	biological_process	"A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
EOG80GG4W	GO:0008101	1/83	decapentaplegic signaling pathway	biological_process	"A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:sart, PMID:17428827]
EOG80GG4W	GO:0005794	1/83	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG80GG4W	GO:0015012	1/83	heparan sulfate proteoglycan biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210]
EOG80GG4W	GO:0050508	1/83	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP." [EC:2.4.1.224, MetaCyc:2.4.1.224-RXN]
EOG80GG4W	GO:0008375	1/83	acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]
EOG80GG4W	GO:0000139	1/83	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG80GG4W	GO:0001888	1/83	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan." [EC:2.4.1.223]
EOG80GG4W	GO:0015014	1/83	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan." [GOC:ai]
EOG80GG4W	GO:0016021	1/83	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80GG4W	GO:0005783	1/83	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG80GG4W	GO:0016055	1/83	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG80GG4W	GO:0006024	1/83	glycosaminoglycan biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]
EOG8PK4Q4	GO:0007264	25/82	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8PK4Q4	GO:0005525	25/82	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8PK4Q4	GO:0015031	24/82	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8PK4Q4	GO:0004767	2/82	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8PK4Q4	GO:0005794	1/82	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8PK4Q4	GO:0005097	1/82	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8PK4Q4	GO:0055037	1/82	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG8PK4Q4	GO:0005515	1/82	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8PK4Q4	GO:0045202	1/82	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8PK4Q4	GO:0032851	1/82	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8PK4Q4	GO:0043025	1/82	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8M947H	GO:0016042	41/113	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8M947H	GO:0004623	41/113	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG8M947H	GO:0005509	41/113	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8M947H	GO:0006644	32/113	phospholipid metabolic process	biological_process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8M947H	GO:0005576	32/113	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8ZCWK1	GO:0008270	6/44	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8N8TJV	GO:0006749	3/39	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG8N8TJV	GO:0003840	3/39	gamma-glutamyltransferase activity	molecular_function	"Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2]
EOG8V9X4R	GO:0006281	27/107	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8V9X4R	GO:0000723	27/107	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8V9X4R	GO:0005524	22/107	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8V9X4R	GO:0005634	16/107	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8V9X4R	GO:0003677	16/107	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8V9X4R	GO:0000002	16/107	mitochondrial genome maintenance	biological_process	"The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw]
EOG8V9X4R	GO:0043141	16/107	ATP-dependent 5'-3' DNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl]
EOG8V9X4R	GO:0005739	16/107	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8V9X4R	GO:0006310	16/107	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8V9X4R	GO:0003678	11/107	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8V9X4R	GO:0004386	2/107	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8N8TJT	GO:0018149	23/73	peptide cross-linking	biological_process	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]
EOG8N8TJT	GO:0003810	21/73	protein-glutamine gamma-glutamyltransferase activity	molecular_function	"Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124]
EOG8N8TJT	GO:0046872	10/73	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QNQ9V	GO:0005509	1/85	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8V9X4T	GO:0000145	23/91	exocyst	cellular_component	"A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152]
EOG8V9X4T	GO:0006887	23/91	exocytosis	biological_process	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
EOG8V9X4T	GO:0005319	1/91	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG83R61V	GO:0020037	24/59	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG83R61V	GO:0005506	24/59	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG83R61V	GO:0016705	23/59	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG83R61V	GO:0004497	22/59	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG83R61V	GO:0070330	1/59	aromatase activity	molecular_function	"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
EOG83R61W	GO:0003887	23/88	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG83R61W	GO:0006281	23/88	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG83R61W	GO:0003684	23/88	damaged DNA binding	molecular_function	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
EOG83R61W	GO:0000287	21/88	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG83R61W	GO:0017125	1/88	deoxycytidyl transferase activity	molecular_function	"Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA." [PMID:10535901]
EOG83R61W	GO:0010569	1/88	regulation of double-strand break repair via homologous recombination	biological_process	"Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]
EOG83R61W	GO:0019985	1/88	translesion synthesis	biological_process	"The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, PMID:10535901]
EOG83R61S	GO:0016020	20/91	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG83R61S	GO:0046873	20/91	metal ion transmembrane transporter activity	molecular_function	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]
EOG83R61S	GO:0007417	1/91	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG83R61S	GO:0007506	1/91	gonadal mesoderm development	biological_process	"The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai]
EOG83R61S	GO:0005385	1/91	zinc ion transmembrane transporter activity	molecular_function	"Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf]
EOG83R61S	GO:0008406	1/91	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG83R61S	GO:0009986	1/91	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG83R61S	GO:0035147	1/91	branch fusion, open tracheal system	biological_process	"Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584]
EOG83R61S	GO:0008354	1/91	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG83R61S	GO:0022008	1/91	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG83R61S	GO:0016477	1/91	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG83R61S	GO:0071577	1/91	zinc II ion transmembrane transport	biological_process	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]
EOG83R61S	GO:0006829	1/91	zinc II ion transport	biological_process	"The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG83R61S	GO:0005886	1/91	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG83R61S	GO:0005887	1/91	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83R61S	GO:0016323	1/91	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG83R61S	GO:0007280	1/91	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG83R61S	GO:0035262	1/91	gonad morphogenesis	biological_process	"The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001]
EOG8V9X4C	GO:0016773	26/127	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8V9X4C	GO:0000123	1/127	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG8V9X4C	GO:0035267	1/127	NuA4 histone acetyltransferase complex	cellular_component	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]
EOG8V9X4C	GO:0043486	1/127	histone exchange	biological_process	"The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]
EOG8V9X4C	GO:0006355	1/127	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8V9X4C	GO:0045747	1/127	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8V9X4C	GO:0000124	1/127	SAGA complex	cellular_component	"A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012]
EOG8V9X4C	GO:0006909	1/127	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8V9X4C	GO:0005875	1/127	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8V9X4C	GO:0000281	1/127	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8V9X4C	GO:0005634	1/127	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8V9X4C	GO:0005703	1/127	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG8V9X4C	GO:0016573	1/127	histone acetylation	biological_process	"The modification of a histone by the addition of an acetyl group." [GOC:ai]
EOG8V9X4C	GO:0005700	1/127	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8V9X4C	GO:0005737	1/127	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8V9X4C	GO:0006351	1/127	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8V9X4C	GO:0035222	1/127	wing disc pattern formation	biological_process	"The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf]
EOG8STVN9	GO:0005634	97/397	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8STVN9	GO:0006351	90/397	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8STVN9	GO:0007275	89/397	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8STVN9	GO:0006355	52/397	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8STVN9	GO:0003677	52/397	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8STVN9	GO:0003700	44/397	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8STVN9	GO:0043565	43/397	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8STVN9	GO:0006366	3/397	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8STVN9	GO:0003705	3/397	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG8STVN9	GO:0045944	3/397	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8STVN9	GO:0048813	2/397	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8STVN9	GO:0048749	2/397	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8STVN9	GO:0048854	2/397	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG8STVN9	GO:0016319	2/397	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8STVN9	GO:0007526	1/397	larval somatic muscle development	biological_process	"The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG8STVN9	GO:0007420	1/397	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG8STVN9	GO:0007628	1/397	adult walking behavior	biological_process	"The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907]
EOG8STVN9	GO:0043704	1/397	photoreceptor cell fate specification	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu]
EOG8STVN9	GO:0045676	1/397	regulation of R7 cell differentiation	biological_process	"Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators]
EOG8STVN9	GO:0035214	1/397	eye-antennal disc development	biological_process	"Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8STVN9	GO:0007455	1/397	eye-antennal disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8STVN9	GO:0043567	1/397	regulation of insulin-like growth factor receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf]
EOG8STVN9	GO:0001745	1/397	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8STVN9	GO:0001158	1/397	enhancer sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH]
EOG8STVN9	GO:0048666	1/397	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8STVN9	GO:0030182	1/397	neuron differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
EOG8STVN9	GO:0008347	1/397	glial cell migration	biological_process	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
EOG8STVN9	GO:0042676	1/397	compound eye cone cell fate commitment	biological_process	"The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu]
EOG8STVN9	GO:0010628	1/397	positive regulation of gene expression	biological_process	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8STVN9	GO:0007517	1/397	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8STVN9	GO:0005515	1/397	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8STVN9	GO:0008056	1/397	ocellus development	biological_process	"The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540]
EOG8STVN9	GO:0004000	1/397	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8STVN9	GO:0048036	1/397	central complex development	biological_process	"The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252]
EOG8STVN9	GO:0040018	1/397	positive regulation of multicellular organism growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8STVN9	GO:0042673	1/397	regulation of retinal cone cell fate specification	biological_process	"Any process that mediates the specification of a cell into a retinal cone cell." [GOC:go_curators]
EOG8STVN9	GO:0042682	1/397	regulation of compound eye cone cell fate specification	biological_process	"Any process that mediates the specification of a cell into a compound eye cone cell." [GOC:mtg_sensu]
EOG8STVN9	GO:0045893	1/397	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8STVN9	GO:0000976	1/397	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8QNQ9D	GO:0003676	25/172	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QNQ9D	GO:0008270	25/172	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8QNQ9D	GO:0044262	11/172	cellular carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
EOG8QNQ9D	GO:0030060	10/172	L-malate dehydrogenase activity	molecular_function	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]
EOG8QNQ9D	GO:0006108	10/172	malate metabolic process	biological_process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]
EOG8QNQ9D	GO:0006099	5/172	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8QNQ9D	GO:0071011	1/172	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8QNQ9D	GO:0016616	1/172	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8QNQ9D	GO:0006909	1/172	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8QNQ9D	GO:0071013	1/172	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8QNQ9D	GO:0000398	1/172	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8MWBMX	GO:0005622	143/592	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8MWBMX	GO:0005215	143/592	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8MWBMX	GO:0022008	1/592	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8MWBMX	GO:0016787	1/592	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8N06WX	GO:0000166	3/10	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8N06WX	GO:0003676	2/10	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG87DCX7	GO:0008061	105/374	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG87DCX7	GO:0006030	105/374	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG87DCX7	GO:0005576	103/374	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG87DCX7	GO:0005615	2/374	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG87DCX7	GO:0010716	1/374	negative regulation of extracellular matrix disassembly	biological_process	"Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
EOG87DCX7	GO:0032504	1/374	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG87DCX7	GO:0040003	1/374	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8MWBMN	GO:0008270	26/99	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8THZ6W	GO:0008270	22/106	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8THZ6W	GO:0003677	7/106	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8THZ6W	GO:0000791	1/106	euchromatin	cellular_component	"A dispersed and relatively uncompacted form of chromatin." [GOC:elh]
EOG8THZ6W	GO:0031936	1/106	negative regulation of chromatin silencing	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah]
EOG8THZ6W	GO:0007480	1/106	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8THZ6W	GO:0046427	1/106	positive regulation of JAK-STAT cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG8THZ6W	GO:0005737	1/106	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8THZ6W	GO:0005700	1/106	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8THZ6W	GO:0006351	1/106	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8THZ6W	GO:0000792	1/106	heterochromatin	cellular_component	"A compact and highly condensed form of chromatin." [GOC:elh]
EOG8THZ6W	GO:0045893	1/106	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8THZ6W	GO:0035556	1/106	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8THZ6W	GO:0006355	1/106	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8THZ6W	GO:0016458	1/106	gene silencing	biological_process	"Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb]
EOG8THZ6W	GO:0003682	1/106	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8THZ6W	GO:0070604	1/106	PBAF complex	cellular_component	"A SWI/SNF-type complex that contains the ATPase product of the mammalian BAF180 gene." [GOC:mah, PMID:16155938, PMID:8895581]
EOG8THZ6W	GO:0005634	1/106	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8THZ6W	GO:0045892	1/106	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8THZ6W	GO:0005701	1/106	polytene chromosome chromocenter	cellular_component	"A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012]
EOG8MWBMC	GO:0051539	40/124	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8MWBMC	GO:0008137	28/124	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8MWBMC	GO:0010181	27/124	FMN binding	molecular_function	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]
EOG8MWBMC	GO:0051287	25/124	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8MWBMC	GO:0016651	12/124	oxidoreductase activity, acting on NAD(P)H	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8MWBMC	GO:0005615	1/124	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8MWBMC	GO:0032504	1/124	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8DRCV3	GO:0003676	3/252	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DRCV3	GO:0015074	3/252	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8DRCV3	GO:0003723	2/252	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8DRCV3	GO:0008270	2/252	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DRCV3	GO:0003964	2/252	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8DRCV3	GO:0004190	1/252	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG85QKVN	GO:0003700	23/93	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG85QKVN	GO:0043565	22/93	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG85QKVN	GO:0005991	1/93	trehalose metabolic process	biological_process	"The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]
EOG85QKVN	GO:0035074	1/93	pupation	biological_process	"The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238]
EOG85QKVN	GO:0042594	1/93	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG85QKVN	GO:0000980	1/93	RNA polymerase II distal enhancer sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH]
EOG85QKVN	GO:0035073	1/93	pupariation	biological_process	"The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
EOG85QKVN	GO:0006355	1/93	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85QKVN	GO:0007591	1/93	molting cycle, chitin-based cuticle	biological_process	"The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu]
EOG85QKVN	GO:0001105	1/93	RNA polymerase II transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG85QKVN	GO:0006641	1/93	triglyceride metabolic process	biological_process	"The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732]
EOG85QKVN	GO:0001102	1/93	RNA polymerase II activating transcription factor binding	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription." [GOC:txnOH]
EOG85QKVN	GO:0007552	1/93	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG85QKVN	GO:0046982	1/93	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG85QKVN	GO:0045944	1/93	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG85QKVJ	GO:0046872	6/14	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85QKVJ	GO:0042732	6/14	D-xylose metabolic process	biological_process	"The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732]
EOG85QKVJ	GO:0009045	6/14	xylose isomerase activity	molecular_function	"Catalysis of the reaction: D-xylose = D-xylulose." [EC:5.3.1.5]
EOG85QKVJ	GO:0006098	6/14	pentose-phosphate shunt	biological_process	"The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]
EOG85QKVJ	GO:0030246	1/14	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG85QKVJ	GO:0003700	1/14	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG85QKVJ	GO:0003677	1/14	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8SN42X	GO:0003824	27/204	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8SN42X	GO:0004802	3/204	transketolase activity	molecular_function	"Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [EC:2.2.1.1, GOC:fmc]
EOG8SN42X	GO:0005875	2/204	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8SN42X	GO:0031122	2/204	cytoplasmic microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
EOG8SN42X	GO:0090063	1/204	positive regulation of microtubule nucleation	biological_process	"Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
EOG8SN42X	GO:0000922	1/204	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8SN42X	GO:0005515	1/204	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8SN42X	GO:0005813	1/204	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8SN42X	GO:0007067	1/204	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8SN42X	GO:0007029	1/204	endoplasmic reticulum organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
EOG8SN42X	GO:0008017	1/204	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8SN42X	GO:0007143	1/204	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8SN42X	GO:0048477	1/204	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8SN42X	GO:0035371	1/204	microtubule plus-end	cellular_component	"The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]
EOG8SN42X	GO:0045450	1/204	bicoid mRNA localization	biological_process	"Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators]
EOG8SN42X	GO:0031935	1/204	regulation of chromatin silencing	biological_process	"Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah]
EOG8SN42X	GO:0007344	1/204	pronuclear fusion	biological_process	"The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X]
EOG8SN42X	GO:0016325	1/204	oocyte microtubule cytoskeleton organization	biological_process	"Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]
EOG8SN42X	GO:0005811	1/204	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8SN42X	GO:0007017	1/204	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8SN42X	GO:0000022	1/204	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8SN42X	GO:0007411	1/204	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8SN42X	GO:0015631	1/204	tubulin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]
EOG85QKVB	GO:0003684	24/90	damaged DNA binding	molecular_function	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
EOG85QKVB	GO:0006303	24/90	double-strand break repair via nonhomologous end joining	biological_process	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]
EOG85QKVB	GO:0000723	24/90	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG85QKVB	GO:0042162	24/90	telomeric DNA binding	molecular_function	"Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]
EOG85QKVB	GO:0004003	24/90	ATP-dependent DNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl]
EOG85QKVB	GO:0043564	24/90	Ku70:Ku80 complex	cellular_component	"Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983]
EOG85QKVB	GO:0003677	1/90	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG85QKVB	GO:0005524	1/90	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG85QKVB	GO:0046982	1/90	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG85QKVB	GO:0005694	1/90	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG85QKVB	GO:0006310	1/90	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8V720R	GO:0003676	5/28	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85TG51	GO:0003700	23/75	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG85TG51	GO:0005634	23/75	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85TG51	GO:0043565	19/75	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG85TG51	GO:0000976	4/75	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG85TG51	GO:0007463	2/75	R2/R5 cell fate commitment	biological_process	"The process in which the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
EOG85TG51	GO:0007601	2/75	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG85TG51	GO:0050896	2/75	response to stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
EOG85TG51	GO:0042067	2/75	establishment of ommatidial planar polarity	biological_process	"The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
EOG85TG51	GO:0048054	1/75	R2/R5 cell differentiation	biological_process	"The process in which relatively unspecialized cells acquire the specialized features of R2 and R5 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid]
EOG85TG51	GO:0045680	1/75	negative regulation of R8 cell differentiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
EOG85TG51	GO:0004000	1/75	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG85TG51	GO:0045464	1/75	R8 cell fate specification	biological_process	"The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [PMID:11880339]
EOG85TG51	GO:0007460	1/75	R8 cell fate commitment	biological_process	"The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883]
EOG85TG51	GO:0001012	1/75	RNA polymerase II regulatory region DNA binding	molecular_function	"Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw]
EOG85TG51	GO:0006351	1/75	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG85TG51	GO:0045944	1/75	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8V720K	GO:0003723	5/22	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8V720K	GO:0003964	5/22	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8KPWRM	GO:0006884	1/234	cell volume homeostasis	biological_process	"Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8KPWRM	GO:0006821	1/234	chloride transport	biological_process	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8KPWRM	GO:0016021	1/234	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KPWRM	GO:0072320	1/234	volume-sensitive chloride channel activity	molecular_function	"Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:mah]
EOG8KPWRM	GO:0044070	1/234	regulation of anion transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
EOG8KPWRM	GO:0005254	1/234	chloride channel activity	molecular_function	"Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8KPWRM	GO:1902476	1/234	chloride transmembrane transport	biological_process	"The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw]
EOG8KPWRM	GO:0005777	1/234	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8909QD	GO:0007165	18/96	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8909QD	GO:0004402	1/96	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8909QG	GO:0006810	24/95	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8909QG	GO:0000166	23/95	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8909QG	GO:0005622	23/95	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8909QG	GO:0003676	22/95	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8909QG	GO:0005515	1/95	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8909QG	GO:0007265	1/95	Ras protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf]
EOG8909QG	GO:0071011	1/95	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8909QG	GO:0016318	1/95	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG8909QG	GO:0000398	1/95	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8909QG	GO:0071013	1/95	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8909QG	GO:0045571	1/95	negative regulation of imaginal disc growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators]
EOG8909QG	GO:0005829	1/95	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8909QG	GO:0005737	1/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8909QG	GO:0001752	1/95	compound eye photoreceptor fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
EOG8909QG	GO:0005811	1/95	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8909QG	GO:0003729	1/95	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8909QT	GO:0046922	5/84	peptide-O-fucosyltransferase activity	molecular_function	"Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]
EOG8909QT	GO:0016757	4/84	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8909QT	GO:0007219	1/84	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8909QT	GO:0045746	1/84	negative regulation of Notch signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8909QT	GO:0005737	1/84	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8909QT	GO:0006004	1/84	fucose metabolic process	biological_process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]
EOG8909QT	GO:0008417	1/84	fucosyltransferase activity	molecular_function	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
EOG8909QT	GO:0009790	1/84	embryo development	biological_process	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
EOG8909QT	GO:0046331	1/84	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8909QT	GO:0008593	1/84	regulation of Notch signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8909QT	GO:0006493	1/84	protein O-linked glycosylation	biological_process	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]
EOG8909QT	GO:0016266	1/84	O-glycan processing	biological_process	"The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure." [GOC:mah, GOC:pr, PMID:10580130]
EOG8909QT	GO:0036066	1/84	protein O-linked fucosylation	biological_process	"The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:sart, PMID:19948734]
EOG8909QT	GO:0036065	1/84	fucosylation	biological_process	"The covalent attachment of a fucosyl group to an acceptor molecule." [CHEBI:62688, GOC:sart, PMID:19948734]
EOG8909QT	GO:0031410	1/84	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG8909QT	GO:0006897	1/84	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8909QT	GO:0005783	1/84	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8909QT	GO:0005112	1/84	Notch binding	molecular_function	"Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb]
EOG8909QT	GO:0006355	1/84	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8909QT	GO:0030163	1/84	protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]
EOG8909QT	GO:0016337	1/84	single organismal cell-cell adhesion	biological_process	"The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb]
EOG8SJ7XB	GO:0005506	40/120	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8SJ7XB	GO:0005739	40/120	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8SJ7XB	GO:0070469	40/120	respiratory chain	cellular_component	"The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684]
EOG8SJ7XB	GO:0009055	40/120	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8SJ7XB	GO:0055114	40/120	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8SJ7XB	GO:0020037	40/120	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8SJ7XB	GO:0006119	2/120	oxidative phosphorylation	biological_process	"The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309]
EOG8SJ7XB	GO:0005743	2/120	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8SJ7XB	GO:0005758	2/120	mitochondrial intermembrane space	cellular_component	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]
EOG8SJ7XB	GO:0007291	1/120	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8SJ7XB	GO:0046669	1/120	regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG8SJ7XB	GO:0006919	1/120	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
EOG8909QR	GO:0008080	45/106	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG8909QR	GO:0016747	20/106	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8S1WQH	GO:0032440	1/88	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8S1WQH	GO:0008301	1/88	DNA binding, bending	molecular_function	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]
EOG8S1WQH	GO:0043565	1/88	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8S1WQH	GO:0006357	1/88	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8S1WQH	GO:0007552	1/88	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG8S1WQH	GO:0005634	1/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8S1WQH	GO:0048813	1/88	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8S1WQH	GO:0006351	1/88	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8S1WQH	GO:0016322	1/88	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG87DCXZ	GO:0030833	25/89	regulation of actin filament polymerization	biological_process	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG87DCXZ	GO:0005856	25/89	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG87DCXZ	GO:0005737	2/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87DCXZ	GO:0003779	1/89	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG87DCXZ	GO:0030866	1/89	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG87DCXZ	GO:0030031	1/89	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG87DCXZ	GO:0046331	1/89	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG87DCXZ	GO:0003899	1/89	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG87DCXZ	GO:0000902	1/89	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG87DCXZ	GO:0008360	1/89	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8DNHJ4	GO:0016791	25/104	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG8DNHJ4	GO:0046872	24/104	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DNHJ4	GO:0035556	24/104	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8DNHJ4	GO:0032483	1/104	regulation of Rab protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]
EOG8DNHJ4	GO:0030674	1/104	protein binding, bridging	molecular_function	"The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:bf, GOC:mah, GOC:vw]
EOG8DNHJ4	GO:0008023	1/104	transcription elongation factor complex	cellular_component	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]
EOG8DNHJ4	GO:0019902	1/104	phosphatase binding	molecular_function	"Interacting selectively and non-covalently with any phosphatase." [GOC:jl]
EOG8DNHJ4	GO:0017137	1/104	Rab GTPase binding	molecular_function	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG8DNHJ4	GO:0036313	1/104	phosphatidylinositol 3-kinase catalytic subunit binding	molecular_function	"Interacting selectively and non-covalently with the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [GOC:bf, PMID:17475214]
EOG8DNHJ4	GO:0005634	1/104	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8DNHJ4	GO:0032456	1/104	endocytic recycling	biological_process	"The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635]
EOG8DNHJ4	GO:0055037	1/104	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG8DNHJ4	GO:0003682	1/104	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8DNHJ4	GO:0017112	1/104	Rab guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8DNHJ4	GO:0030866	1/104	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8DNHJ4	GO:0005938	1/104	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8DNHJ4	GO:0032313	1/104	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8DNHJ4	GO:0032968	1/104	positive regulation of transcription elongation from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
EOG8DNHJ4	GO:0000278	1/104	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8DFS2Q	GO:0005515	1/95	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8DFS2Q	GO:0045893	1/95	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8DFS2Q	GO:0042981	1/95	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8DFS2Q	GO:0006979	1/95	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8DFS2Q	GO:0008270	1/95	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DFS2Q	GO:0008340	1/95	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8DFS2R	GO:0008270	4/85	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DFS2R	GO:0003676	2/85	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DFS2T	GO:0000502	2/92	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG8DFS2T	GO:0005737	1/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8DFS2T	GO:0000338	1/92	protein deneddylation	biological_process	"The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]
EOG8DFS2T	GO:0019781	1/92	NEDD8 activating enzyme activity	molecular_function	"Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade." [PMID:12646924]
EOG8DFS2T	GO:0007095	1/92	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8DFS2T	GO:0007275	1/92	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8DFS2T	GO:0008180	1/92	COP9 signalosome	cellular_component	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]
EOG8DFS2T	GO:0050821	1/92	protein stabilization	biological_process	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]
EOG8DFS2T	GO:0051726	1/92	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8DFS2T	GO:0046331	1/92	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8DFS2T	GO:0048477	1/92	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8DFS2W	GO:0006886	2/54	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8DFS2W	GO:0046872	1/54	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DFS2W	GO:0000016	1/54	lactase activity	molecular_function	"Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [EC:3.2.1.108]
EOG8B013K	GO:0005975	29/97	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8B013K	GO:0000287	23/97	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8B013K	GO:0004610	22/97	phosphoacetylglucosamine mutase activity	molecular_function	"Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3, RHEA:23807]
EOG8B013K	GO:0016868	7/97	intramolecular transferase activity, phosphotransferases	molecular_function	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]
EOG8B013K	GO:0045743	1/97	positive regulation of fibroblast growth factor receptor signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8B013K	GO:0060438	1/97	trachea development	biological_process	"The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG8B013K	GO:0001707	1/97	mesoderm formation	biological_process	"The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators]
EOG8B013K	GO:0006048	1/97	UDP-N-acetylglucosamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
EOG8B013K	GO:0005829	1/97	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8B013F	GO:0055085	21/84	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8B013F	GO:0016021	21/84	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG851H4R	GO:0006629	31/166	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG851H4R	GO:0004806	30/166	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG851H4R	GO:0007602	1/166	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG851H4R	GO:0005737	1/166	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG851H4R	GO:0007155	1/166	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG851H4R	GO:0031532	1/166	actin cytoskeleton reorganization	biological_process	"A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]
EOG851H4R	GO:0004465	1/166	lipoprotein lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein." [EC:3.1.1.34, GOC:bf]
EOG851H4S	GO:0005524	2/12	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG851H4S	GO:0016887	2/12	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8DFS2D	GO:0005216	18/68	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8DFS2D	GO:0016021	18/68	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DFS2D	GO:0006812	1/68	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8DFS2D	GO:0004692	1/68	cGMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
EOG8DFS2D	GO:0005221	1/68	intracellular cyclic nucleotide activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG8DFS2D	GO:0017071	1/68	intracellular cyclic nucleotide activated cation channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah]
EOG8DFS2D	GO:0019935	1/68	cyclic-nucleotide-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
EOG851H4X	GO:0016021	117/291	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG851H4X	GO:0007155	117/291	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG851H4X	GO:0048102	2/291	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG851H4X	GO:0005044	2/291	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG851H4X	GO:0016063	2/291	rhodopsin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
EOG851H4X	GO:0007602	2/291	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG851H4X	GO:0035071	2/291	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG851H4X	GO:0006898	2/291	receptor-mediated endocytosis	biological_process	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
EOG851H4X	GO:0002433	1/291	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	biological_process	"An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, GOC:mtg_15nov05, ISBN:0781735149]
EOG851H4X	GO:0006909	1/291	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG851H4X	GO:0006911	1/291	phagocytosis, engulfment	biological_process	"The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149]
EOG851H4X	GO:0006915	1/291	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG851H4X	GO:0006955	1/291	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG851H4X	GO:0046867	1/291	carotenoid transport	biological_process	"The directed movement of carotenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:ai]
EOG851H4X	GO:0016116	1/291	carotenoid metabolic process	biological_process	"The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684]
EOG851H4X	GO:0042116	1/291	macrophage activation	biological_process	"A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:14506301]
EOG851H4X	GO:0005886	1/291	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG851H4X	GO:0050764	1/291	regulation of phagocytosis	biological_process	"Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai]
EOG851H4X	GO:0004872	1/291	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG851H4X	GO:0043052	1/291	thermotaxis	biological_process	"The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
EOG851H4X	GO:0005764	1/291	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG898XGZ	GO:0003676	7/80	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG898XGZ	GO:0015074	3/80	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG898XGZ	GO:0004252	1/80	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8B013V	GO:0016021	22/87	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8B013V	GO:0015171	1/87	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8B013V	GO:0003333	1/87	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG873S7G	GO:0003700	25/86	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG873S7G	GO:0043565	25/86	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG873S7G	GO:0046983	1/86	protein dimerization activity	molecular_function	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]
EOG84F8R8	GO:0005216	27/104	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG84F8R8	GO:0016021	27/104	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84F8R8	GO:0048512	1/104	circadian behavior	biological_process	"The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr]
EOG84F8R8	GO:0008344	1/104	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG84F8R8	GO:0050975	1/104	sensory perception of touch	biological_process	"The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]
EOG84F8R8	GO:0042752	1/104	regulation of circadian rhythm	biological_process	"Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]
EOG84F8R8	GO:0086010	1/104	membrane depolarization during action potential	biological_process	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
EOG84F8R8	GO:0022008	1/104	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84F8R8	GO:0070509	1/104	calcium ion import	biological_process	"The directed movement of calcium ions into a cell or organelle." [GOC:mah]
EOG84F8R8	GO:0005245	1/104	voltage-gated calcium channel activity	molecular_function	"Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
EOG84F8R8	GO:0045475	1/104	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG84F8R8	GO:0072347	1/104	response to anesthetic	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart]
EOG84F8R8	GO:0035176	1/104	social behavior	biological_process	"Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group." [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior]
EOG84F8R8	GO:0005886	1/104	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG84F8R8	GO:0043025	1/104	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG84F8R8	GO:0043679	1/104	axon terminus	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl]
EOG85F036	GO:0007275	26/99	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG85F036	GO:0004872	26/99	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG85F036	GO:0005509	23/99	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG85F036	GO:0016021	21/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85F036	GO:0016020	5/99	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8TF310	GO:0003676	27/104	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8TF310	GO:0005634	3/104	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TF310	GO:0008270	3/104	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TF310	GO:0003677	1/104	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TF313	GO:0005089	8/48	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8TF313	GO:0046872	8/48	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TF314	GO:0003964	1/6	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8TF314	GO:0008270	1/6	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TF314	GO:0003723	1/6	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8TF314	GO:0006351	1/6	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8TF314	GO:0003677	1/6	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TF314	GO:0003899	1/6	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8SFCKX	GO:0005524	50/173	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SFCKX	GO:0006438	50/173	valyl-tRNA aminoacylation	biological_process	"The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8SFCKX	GO:0004832	50/173	valine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.9, RHEA:10707]
EOG8SFCKX	GO:0002161	49/173	aminoacyl-tRNA editing activity	molecular_function	"The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889]
EOG8SFCKX	GO:0005737	12/173	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SFCKX	GO:0022008	1/173	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8SFCKX	GO:0003676	1/173	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SFCKX	GO:0004818	1/173	glutamate-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17]
EOG85F03S	GO:0005524	22/92	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG85F03S	GO:0017111	21/92	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG85F03S	GO:0006260	1/92	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG85F03S	GO:0006629	1/92	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG85F03S	GO:0008283	1/92	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG85F03S	GO:0003689	1/92	DNA clamp loader activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778]
EOG85F03S	GO:0005634	1/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85F03S	GO:0005663	1/92	DNA replication factor C complex	cellular_component	"A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides." [PMID:14614842, PMID:14646196, PMID:16172520]
EOG8Z38XG	GO:0003676	7/21	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Z38XG	GO:0003677	2/21	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG85F03G	GO:0016021	23/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85F03G	GO:0008158	22/96	hedgehog receptor activity	molecular_function	"Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137]
EOG85F03G	GO:0016020	2/96	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG85F03G	GO:0007275	1/96	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG85F03G	GO:0007280	1/96	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG85F03G	GO:0006887	1/96	exocytosis	biological_process	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
EOG85F03G	GO:0005215	1/96	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG85F03G	GO:0007224	1/96	smoothened signaling pathway	biological_process	"A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
EOG85F03H	GO:0030170	119/445	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG85F03H	GO:0006520	119/445	cellular amino acid metabolic process	biological_process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]
EOG85F03H	GO:0016831	110/445	carboxy-lyase activity	molecular_function	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]
EOG85F03H	GO:0004058	9/445	aromatic-L-amino-acid decarboxylase activity	molecular_function	"Catalysis of the reaction: L-amino acid + H+ = R-H + CO2." [EC:4.1.1.28]
EOG85F03H	GO:0016491	6/445	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG85F03H	GO:0006584	2/445	catecholamine metabolic process	biological_process	"The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0042302	2/445	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG85F03H	GO:0043052	2/445	thermotaxis	biological_process	"The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
EOG85F03H	GO:0040003	2/445	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG85F03H	GO:0004837	2/445	tyrosine decarboxylase activity	molecular_function	"Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25]
EOG85F03H	GO:0042423	2/445	catecholamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0007611	1/445	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG85F03H	GO:0048066	1/445	developmental pigmentation	biological_process	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
EOG85F03H	GO:0035220	1/445	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG85F03H	GO:0007626	1/445	locomotory behavior	biological_process	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
EOG85F03H	GO:0007619	1/445	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG85F03H	GO:0046592	1/445	polyamine oxidase activity	molecular_function	"Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380]
EOG85F03H	GO:0048148	1/445	behavioral response to cocaine	biological_process	"Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid]
EOG85F03H	GO:0048082	1/445	regulation of adult chitin-containing cuticle pigmentation	biological_process	"Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
EOG85F03H	GO:0048085	1/445	adult chitin-containing cuticle pigmentation	biological_process	"Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
EOG85F03H	GO:0007615	1/445	anesthesia-resistant memory	biological_process	"The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531]
EOG85F03H	GO:0006587	1/445	serotonin biosynthetic process from tryptophan	biological_process	"The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0048149	1/445	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG85F03H	GO:0009611	1/445	response to wounding	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators]
EOG85F03H	GO:0040040	1/445	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG85F03H	GO:0018991	1/445	oviposition	biological_process	"The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems]
EOG85F03H	GO:0019239	1/445	deaminase activity	molecular_function	"Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl]
EOG85F03H	GO:0040007	1/445	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG85F03H	GO:0008062	1/445	eclosion rhythm	biological_process	"The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043]
EOG85F03H	GO:0004398	1/445	histidine decarboxylase activity	molecular_function	"Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22]
EOG85F03H	GO:0006585	1/445	dopamine biosynthetic process from tyrosine	biological_process	"The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine." [GOC:bf, GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0007616	1/445	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8SXQTD	GO:0004222	5/19	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG88KTVH	GO:0007218	37/97	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG88KTVH	GO:0018990	37/97	ecdysis, chitin-based cuticle	biological_process	"The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG88KTVH	GO:0005576	2/97	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG88KTVH	GO:0007562	1/97	eclosion	biological_process	"The emergence of an adult insect from a pupa case." [GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461]
EOG88KTVH	GO:0008031	1/97	eclosion hormone activity	molecular_function	"The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis." [GOC:mah, ISBN:0198506732]
EOG88KTVH	GO:0005184	1/97	neuropeptide hormone activity	molecular_function	"The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]
EOG88KTVH	GO:0007563	1/97	regulation of eclosion	biological_process	"Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg." [GOC:go_curators, ISBN:0198600461]
EOG8PZMNS	GO:0016021	26/92	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PZMNS	GO:0004930	23/92	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8PZMNS	GO:0001609	3/92	G-protein coupled adenosine receptor activity	molecular_function	"Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah, PMID:9755289]
EOG8PZMNS	GO:0005975	2/92	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8PZMNS	GO:0004715	2/92	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8PZMNS	GO:0016810	2/92	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
EOG8PZMNS	GO:0090281	1/92	negative regulation of calcium ion import	biological_process	"Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF]
EOG8PZMNS	GO:0007186	1/92	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8PZMNS	GO:0007268	1/92	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8PZMNS	GO:0022008	1/92	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8PZMNS	GO:0001973	1/92	adenosine receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:dph]
EOG8PZMNS	GO:0008306	1/92	associative learning	biological_process	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
EOG8PZMNS	GO:0006109	1/92	regulation of carbohydrate metabolic process	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators]
EOG85B3ZM	GO:0008121	12/49	ubiquinol-cytochrome-c reductase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]
EOG85B3ZM	GO:0009055	12/49	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8PZMNQ	GO:0008270	21/64	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PZMNQ	GO:0016874	3/64	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8PZMNQ	GO:0005634	1/64	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PZMNQ	GO:0006351	1/64	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8PZMNQ	GO:0003677	1/64	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8PZMNQ	GO:0001707	1/64	mesoderm formation	biological_process	"The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators]
EOG8PZMNQ	GO:0016021	1/64	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PZMNQ	GO:0016567	1/64	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8PZMNQ	GO:0005768	1/64	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG8PZMNQ	GO:0006355	1/64	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8PZMNV	GO:0008889	21/71	glycerophosphodiester phosphodiesterase activity	molecular_function	"Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]
EOG8PZMNV	GO:0006071	21/71	glycerol metabolic process	biological_process	"The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]
EOG8PZMNV	GO:0006629	21/71	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8PZMNV	GO:0005272	1/71	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8PZMNV	GO:0016020	1/71	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8PZMNV	GO:0048812	1/71	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG89S8M7	GO:0046856	15/84	phosphatidylinositol dephosphorylation	biological_process	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]
EOG89S8M7	GO:0000166	14/84	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG89S8M7	GO:0042578	13/84	phosphoric ester hydrolase activity	molecular_function	"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]
EOG89S8M7	GO:0004439	3/84	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36, RHEA:22767]
EOG89S8M7	GO:0003676	2/84	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89S8M7	GO:0016311	1/84	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG89S8M7	GO:0046030	1/84	inositol trisphosphate phosphatase activity	molecular_function	"Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate." [GOC:bf]
EOG89S8M7	GO:0012506	1/84	vesicle membrane	cellular_component	"The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah]
EOG89S8M7	GO:0004445	1/84	inositol-polyphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56]
EOG89S8M7	GO:0050803	1/84	regulation of synapse structure or activity	biological_process	"Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]
EOG89S8M7	GO:0048488	1/84	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG89S8M7	GO:0048790	1/84	maintenance of presynaptic active zone structure	biological_process	"The process in which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr]
EOG89S8M7	GO:0043195	1/84	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG89S8M7	GO:0052659	1/84	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56, RHEA:11395]
EOG89S8M7	GO:0007269	1/84	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG89S8M7	GO:0052658	1/84	inositol-1,4,5-trisphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate." [EC:3.1.3.56, RHEA:19800]
EOG8VDSC9	GO:0004198	24/94	calcium-dependent cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]
EOG8VDSC9	GO:0005622	24/94	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8VDSC9	GO:0008270	20/94	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VDSC9	GO:0050896	1/94	response to stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
EOG8VDSC9	GO:0007601	1/94	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8VDSC9	GO:0005737	1/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8VDSC9	GO:0006508	1/94	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8VDSC9	GO:0046872	1/94	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8VDSC9	GO:0007399	1/94	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8VDSC9	GO:0003676	1/94	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8B0134	GO:0005977	29/107	glycogen metabolic process	biological_process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]
EOG8B0134	GO:0004553	26/107	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8B0134	GO:0016301	5/107	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8B0134	GO:0005886	1/107	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8MWBN9	GO:0016773	1/7	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8MWBN9	GO:0016491	1/7	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8284GH	GO:0008283	1/91	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8284GH	GO:0000347	1/91	THO complex	cellular_component	"The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]
EOG8284GH	GO:0009408	1/91	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8JT2M4	GO:0050660	28/94	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8JT2M4	GO:0003995	26/94	acyl-CoA dehydrogenase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]
EOG8JT2M4	GO:0008470	2/94	isovaleryl-CoA dehydrogenase activity	molecular_function	"Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF." [EC:1.3.99.10]
EOG8RJJH4	GO:0016021	1/10	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RJJH4	GO:0043682	1/10	copper-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+ = ADP + phosphate + Cu2+, directly driving the transport of the copper ions across a membrane." [GOC:jl]
EOG8RJJH4	GO:0016787	1/10	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8RJJH4	GO:0003824	1/10	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG834ZKW	GO:0008080	5/100	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG834ZKW	GO:0004415	1/100	hyalurononglucosaminidase activity	molecular_function	"Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35]
EOG834ZKW	GO:0045475	1/100	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG834ZKW	GO:0006491	1/100	N-glycan processing	biological_process	"The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198]
EOG8284GX	GO:0000398	24/85	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8284GX	GO:0000166	24/85	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8284GX	GO:0017069	23/85	snRNA binding	molecular_function	"Interacting selectively and non-covalently with a small nuclear RNA (snRNA)." [GOC:mah]
EOG8284GX	GO:0030529	6/85	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8284GX	GO:0019013	5/85	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8284GX	GO:0003729	1/85	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8284GX	GO:0008380	1/85	RNA splicing	biological_process	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]
EOG8284GX	GO:0000381	1/85	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8284GX	GO:0097158	1/85	pre-mRNA intronic pyrimidine-rich binding	molecular_function	"Interacting selectively and non-covalently with a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624, PMID:16777844]
EOG8284GX	GO:0030619	1/85	U1 snRNA binding	molecular_function	"Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA)." [GOC:mah]
EOG8284GX	GO:0005685	1/85	U1 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U1." [GOC:krc, GOC:mah]
EOG8284GX	GO:0007539	1/85	primary sex determination, soma	biological_process	"The transmission of information about sexual status from the initial, general, determination to signals specific to the soma." [GOC:ems]
EOG8284GX	GO:0071013	1/85	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8284GX	GO:0008266	1/85	poly(U) RNA binding	molecular_function	"Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule." [GOC:mah]
EOG8284GX	GO:0030532	1/85	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8284GX	GO:0048477	1/85	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8284GX	GO:0005686	1/85	U2 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U2." [GOC:krc, GOC:mah]
EOG8284GX	GO:0071011	1/85	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8284GX	GO:0035614	1/85	snRNA stem-loop binding	molecular_function	"Interacting selectively and non-covalently with a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544]
EOG8284GX	GO:0019099	1/85	female germ-line sex determination	biological_process	"The determination of sex and sexual phenotype in a female organism's germ line." [GOC:mah]
EOG8284GX	GO:0005515	1/85	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8284GX	GO:0005634	1/85	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8284GX	GO:0030620	1/85	U2 snRNA binding	molecular_function	"Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA)." [GOC:jl]
EOG8284GX	GO:0043234	1/85	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8284GX	GO:0042802	1/85	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG85XB8W	GO:0007018	83/336	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG85XB8W	GO:0003777	82/336	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG85XB8W	GO:0030286	71/336	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG85XB8W	GO:0005524	54/336	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG85XB8W	GO:0006072	10/336	glycerol-3-phosphate metabolic process	biological_process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]
EOG85XB8W	GO:0009331	10/336	glycerol-3-phosphate dehydrogenase complex	cellular_component	"An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3]
EOG85XB8W	GO:0016887	9/336	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG85XB8W	GO:0004368	9/336	glycerol-3-phosphate dehydrogenase activity	molecular_function	"Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol." [EC:1.1.5.3]
EOG85XB8W	GO:0042623	3/336	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG85XB8W	GO:0006200	3/336	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG85XB8W	GO:0005875	2/336	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG85XB8W	GO:0006302	1/336	double-strand break repair	biological_process	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]
EOG85XB8W	GO:2001019	1/336	positive regulation of retrograde axon cargo transport	biological_process	"Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol]
EOG85XB8W	GO:0005634	1/336	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85XB8W	GO:0005509	1/336	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG85XB8W	GO:0004527	1/336	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG85XB8W	GO:0007605	1/336	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG85XB8W	GO:0004519	1/336	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG85XB8W	GO:0052591	1/336	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	molecular_function	"Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." [MetaCyc:GLYC3PDEHYDROG-RXN]
EOG85XB8W	GO:0007126	1/336	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG85XB8W	GO:0030145	1/336	manganese ion binding	molecular_function	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
EOG83N9SR	GO:0008168	2/8	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG83N9SR	GO:0006779	2/8	porphyrin-containing compound biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732]
EOG83N9SR	GO:0051537	2/8	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG83N9SR	GO:0043115	2/8	precorrin-2 dehydrogenase activity	molecular_function	"Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin." [EC:1.3.1.76, RHEA:15616]
EOG83N9SR	GO:0020037	1/8	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG83N9SR	GO:0008942	1/8	nitrite reductase [NAD(P)H] activity	molecular_function	"Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = nitrite + 3 NAD(P)H + 3 H+." [EC:1.7.1.4]
EOG83N9SR	GO:0050660	1/8	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG83N9SR	GO:0042128	1/8	nitrate assimilation	biological_process	"The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances." [GOC:das, GOC:mah, PMID:10542156, PMID:8122899]
EOG847J7N	GO:0003677	22/137	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG847J7N	GO:0003676	20/137	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG847J7N	GO:0010628	1/137	positive regulation of gene expression	biological_process	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG847J7N	GO:0008270	1/137	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG847J7N	GO:2000495	1/137	regulation of cell proliferation involved in compound eye morphogenesis	biological_process	"Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]
EOG847J7N	GO:0051726	1/137	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG847J7N	GO:0042023	1/137	DNA endoreduplication	biological_process	"Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw]
EOG847J7N	GO:0006355	1/137	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG847J7N	GO:0048749	1/137	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG847J7N	GO:0006366	1/137	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG847J7N	GO:0006357	1/137	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG847J7N	GO:0005667	1/137	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG847J7N	GO:0051123	1/137	RNA polymerase II transcriptional preinitiation complex assembly	biological_process	"The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:10882737, PMID:15020047]
EOG847J7N	GO:0042981	1/137	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG847J7N	GO:0003700	1/137	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG847J7N	GO:0022416	1/137	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG847J7N	GO:0005634	1/137	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG847J7N	GO:0048813	1/137	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG847J7N	GO:2000278	1/137	regulation of DNA biosynthetic process	biological_process	"Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]
EOG847J7N	GO:0001745	1/137	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG847J7N	GO:0004222	1/137	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG847J7N	GO:0022008	1/137	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG847J7N	GO:0045035	1/137	sensory organ precursor cell division	biological_process	"The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597]
EOG847J7N	GO:0006260	1/137	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG847J7N	GO:0006264	1/137	mitochondrial DNA replication	biological_process	"The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai]
EOG847J7N	GO:0005700	1/137	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG847J7N	GO:0000976	1/137	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG847J7N	GO:0031012	1/137	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG847J7N	GO:0045893	1/137	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG847J7N	GO:0007052	1/137	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG83N9SZ	GO:0005975	52/148	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG83N9SZ	GO:0004565	47/148	beta-galactosidase activity	molecular_function	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]
EOG83N9SZ	GO:0004553	5/148	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG83N9SZ	GO:0048102	1/148	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG83N9SZ	GO:0035071	1/148	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8Z919V	GO:0008241	93/395	peptidyl-dipeptidase activity	molecular_function	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]
EOG8Z919V	GO:0016020	92/395	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Z919V	GO:0008237	91/395	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8Z919V	GO:0004180	14/395	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8Z919V	GO:0005615	2/395	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8Z919V	GO:0016491	2/395	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8Z919V	GO:0006508	2/395	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8Z919V	GO:0045938	1/395	positive regulation of circadian sleep/wake cycle, sleep	biological_process	"Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators]
EOG8Z919V	GO:0007289	1/395	spermatid nucleus differentiation	biological_process	"The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah]
EOG8Z919V	GO:0009609	1/395	response to symbiotic bacterium	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism." [GOC:hb, ISBN:0198506732]
EOG8Z919V	GO:0005576	1/395	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Z919V	GO:0046872	1/395	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z919V	GO:0004222	1/395	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8Z919V	GO:0007291	1/395	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8Z919V	GO:0007507	1/395	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8Z919V	GO:0003700	1/395	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z919V	GO:0016021	1/395	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z919V	GO:0005634	1/395	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z919V	GO:0005515	1/395	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8Z919V	GO:0030431	1/395	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8Z919V	GO:0007552	1/395	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG8Z919V	GO:0008270	1/395	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Z919V	GO:0043565	1/395	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8F7R23	GO:0043565	24/88	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8F7R23	GO:0045944	1/88	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8F7R23	GO:0007424	1/88	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8F7R23	GO:0003713	1/88	transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8F7R23	GO:0030674	1/88	protein binding, bridging	molecular_function	"The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:bf, GOC:mah, GOC:vw]
EOG8F7R23	GO:0005737	1/88	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8F7R23	GO:0007417	1/88	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8F7R23	GO:0005634	1/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8F7R23	GO:0048813	1/88	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG83N9SF	GO:0006511	25/93	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG83N9SF	GO:0008234	22/93	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG83N9SF	GO:0008233	2/93	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG83N9SF	GO:0050829	1/93	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG83N9SF	GO:0007097	1/93	nuclear migration	biological_process	"The directed movement of the nucleus." [GOC:ai]
EOG83N9SF	GO:0048749	1/93	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG83N9SF	GO:0048477	1/93	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG83N9SF	GO:0009950	1/93	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG83N9SF	GO:0045861	1/93	negative regulation of proteolysis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
EOG83N9SF	GO:0005515	1/93	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG83N9SF	GO:0007349	1/93	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG83N9SF	GO:0006897	1/93	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG83N9SF	GO:0016579	1/93	protein deubiquitination	biological_process	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]
EOG83N9SF	GO:0008583	1/93	mystery cell differentiation	biological_process	"The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster." [ISBN:0632030488, PMID:1295747]
EOG83N9SF	GO:0004221	1/93	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG83N9SF	GO:0008354	1/93	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG83N9SF	GO:0045824	1/93	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG83N9SF	GO:0007601	1/93	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG83N9SF	GO:0004843	1/93	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG83N9SF	GO:0005737	1/93	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83N9SK	GO:0046427	1/98	positive regulation of JAK-STAT cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG83N9SK	GO:0008270	1/98	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83N9SK	GO:0016905	1/98	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG83N9SK	GO:0004402	1/98	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG83N9SK	GO:0003676	1/98	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83N9SK	GO:0007095	1/98	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG83N9SK	GO:0003677	1/98	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG83N9SK	GO:0006909	1/98	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8R7XQG	GO:0004842	22/126	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8R7XQG	GO:0008270	22/126	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8R7XQG	GO:0007601	2/126	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8R7XQG	GO:0050896	2/126	response to stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
EOG8R7XQG	GO:0005516	2/126	calmodulin binding	molecular_function	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
EOG8R7XQG	GO:0005319	2/126	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG8R7XQG	GO:0007291	2/126	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8R7XQG	GO:0007286	2/126	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG8R7XQG	GO:0007399	1/126	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8R7XQG	GO:0042066	1/126	perineurial glial growth	biological_process	"Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons." [GOC:mah, PMID:11517334, PMID:18176560]
EOG8R7XQG	GO:0042065	1/126	glial cell growth	biological_process	"Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jid]
EOG86HJS1	GO:0005634	21/98	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86HJS1	GO:0003677	21/98	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86HJS1	GO:0007379	1/98	segment specification	biological_process	"The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG86HJS1	GO:0008134	1/98	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG86HJS1	GO:0000122	1/98	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG86HJS1	GO:0045892	1/98	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG86HJS1	GO:0005515	1/98	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG86HJS1	GO:0035218	1/98	leg disc development	biological_process	"Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
EOG86HJS1	GO:0008301	1/98	DNA binding, bending	molecular_function	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]
EOG86HJS1	GO:0005700	1/98	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG86HJS1	GO:0006268	1/98	DNA unwinding involved in DNA replication	biological_process	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194]
EOG86HJS1	GO:0008348	1/98	negative regulation of antimicrobial humoral response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." [GOC:go_curators]
EOG86HJS1	GO:0017055	1/98	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators]
EOG86HJS1	GO:0006338	1/98	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG86HJS1	GO:0043388	1/98	positive regulation of DNA binding	biological_process	"Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
EOG86HJS1	GO:0003697	1/98	single-stranded DNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174]
EOG86HJS1	GO:0017025	1/98	TBP-class protein binding	molecular_function	"Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]
EOG86HJS1	GO:0032502	1/98	developmental process	biological_process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]
EOG86HJS1	GO:0032440	1/98	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG86HJS0	GO:0016021	39/104	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86HJS0	GO:0006810	38/104	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8616N8	GO:0003676	7/1106	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8616N8	GO:0003677	3/1106	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8616N8	GO:0008270	3/1106	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8616N8	GO:0003964	2/1106	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8616N8	GO:0015074	2/1106	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8616N8	GO:0003723	2/1106	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8616N8	GO:0004190	1/1106	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8616N8	GO:0008237	1/1106	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG847J75	GO:0005097	27/95	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8K0T47	GO:0008270	5/119	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8K0T47	GO:0003676	5/119	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K0T47	GO:0004190	2/119	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8K0T41	GO:0008060	21/87	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8K0T41	GO:0008270	21/87	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8K0T41	GO:0032312	21/87	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8K0T41	GO:0005634	1/87	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8K0T41	GO:0043547	1/87	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8K0T41	GO:0003676	1/87	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K0T40	GO:0003676	10/117	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K0T40	GO:0007606	1/117	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8K0T40	GO:0005576	1/117	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8K0T40	GO:0003723	1/117	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8K0T40	GO:0008270	1/117	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8K0T40	GO:0003964	1/117	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG847J73	GO:0004842	22/102	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG847J73	GO:0005737	1/102	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG847J73	GO:0005634	1/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG847J73	GO:0042787	1/102	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological_process	"The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]
EOG89KJ4V	GO:0005634	1/79	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG89KJ4V	GO:0007067	1/79	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG89KJ4V	GO:0006260	1/79	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG89KJ4S	GO:0045466	1/215	R7 cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339]
EOG89KJ4S	GO:0007465	1/215	R7 cell fate commitment	biological_process	"The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883]
EOG89KJ4S	GO:0019897	1/215	extrinsic component of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]
EOG89KJ4S	GO:0007611	1/215	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG89KJ4S	GO:0048149	1/215	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG89KJ4S	GO:0042332	1/215	gravitaxis	biological_process	"The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
EOG89KJ4S	GO:0007616	1/215	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG89KJ4S	GO:0008355	1/215	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG89KJ4S	GO:0007156	1/215	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG89KJ4Z	GO:0005874	72/234	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG89KJ4Z	GO:0005525	72/234	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG89KJ4Z	GO:0005200	71/234	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG89KJ4Z	GO:0003924	70/234	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG89KJ4Z	GO:0007017	70/234	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG89KJ4Z	GO:0051258	70/234	protein polymerization	biological_process	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
EOG89KJ4Z	GO:0005737	64/234	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG89KJ4Z	GO:0051298	2/234	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG89KJ4Z	GO:0007435	1/234	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG89KJ4Z	GO:0016203	1/234	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG886BSZ	GO:0016021	26/104	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG886BSZ	GO:0004930	25/104	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG886BSZ	GO:0001587	1/104	Gq/11-coupled serotonin receptor activity	molecular_function	"Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels." [GOC:bf, GOC:mah, PMID:18571247, PMID:18703043]
EOG886BSZ	GO:0004993	1/104	serotonin receptor activity	molecular_function	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai]
EOG886BSZ	GO:0007210	1/104	serotonin receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah]
EOG886BSZ	GO:2000253	1/104	positive regulation of feeding behavior	biological_process	"Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol]
EOG886BSZ	GO:0008227	1/104	G-protein coupled amine receptor activity	molecular_function	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
EOG886BSZ	GO:0005886	1/104	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG886BSZ	GO:0007377	1/104	germ-band extension	biological_process	"Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:08795694238]
EOG80S2ZG	GO:0003964	4/31	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG80S2ZG	GO:0003723	4/31	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8284G3	GO:0008654	24/87	phospholipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8284G3	GO:0006021	24/87	inositol biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, ISBN:0198547684]
EOG8284G3	GO:0004512	24/87	inositol-3-phosphate synthase activity	molecular_function	"Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [EC:5.5.1.4, RHEA:10719]
EOG8284G3	GO:0005737	1/87	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8284G2	GO:0006950	2/85	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8284G2	GO:0003824	1/85	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG89KJ4N	GO:0003676	8/76	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89KJ4N	GO:0008270	8/76	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81NX0Z	GO:0003682	10/102	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG81NX0Z	GO:0008270	3/102	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81NX0Z	GO:0009649	1/102	entrainment of circadian clock	biological_process	"The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid]
EOG81NX0Z	GO:0000077	1/102	DNA damage checkpoint	biological_process	"A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle]
EOG8VMHZG	GO:0005230	6/66	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8VMHZG	GO:0016021	6/66	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HX7F3	GO:0005525	23/95	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8HX7F3	GO:0005622	23/95	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8HX7F3	GO:0007264	23/95	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8HX7F3	GO:0035011	1/95	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG8HX7F1	GO:0005524	29/93	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8HX7F1	GO:0003677	29/93	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8HX7F1	GO:0042555	27/93	MCM complex	cellular_component	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]
EOG8HX7F1	GO:0005634	27/93	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HX7F1	GO:0006270	27/93	DNA replication initiation	biological_process	"The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194]
EOG8HX7F1	GO:0003678	27/93	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8HX7F1	GO:0006260	3/93	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8HX7F1	GO:0030261	1/93	chromosome condensation	biological_process	"The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8HX7F1	GO:0016020	1/93	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HX7F1	GO:0008234	1/93	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8HX7F1	GO:0032508	1/93	DNA duplex unwinding	biological_process	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]
EOG8HX7F1	GO:0005515	1/93	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8HX7F1	GO:0022008	1/93	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8HX7F1	GO:0005272	1/93	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8HX7F1	GO:0046872	1/93	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HX7F1	GO:0051301	1/93	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8HX7F1	GO:0046331	1/93	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8HX7F1	GO:0007049	1/93	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG886BW0	GO:0043565	1/74	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG886BW0	GO:0003700	1/74	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG886BW0	GO:0016772	1/74	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8HX7F6	GO:0004867	1/109	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG886BW5	GO:0035556	5/13	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG886BW5	GO:0005622	4/13	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG89626T	GO:0003824	6/118	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG89626T	GO:0016787	3/118	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG89626T	GO:0052689	1/118	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG89626T	GO:0005811	1/118	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG89626T	GO:0008152	1/118	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG89626T	GO:0004177	1/118	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG83V296	GO:0008270	22/87	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83V297	GO:0003920	7/48	GMP reductase activity	molecular_function	"Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH." [EC:1.7.1.7, RHEA:17188]
EOG83V297	GO:0009117	7/48	nucleotide metabolic process	biological_process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]
EOG83V297	GO:0046872	7/48	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83V297	GO:1902560	6/48	GMP reductase complex	cellular_component	"A protein complex which is capable of GMP reductase activity. It catalysis of the irreversible reaction: IMP + NADP(+) + NH(4)(+) <= GMP + 2 H(+) + NADPH." [GOC:bhm, GOC:TermGenie, PMID:12009299]
EOG83V295	GO:0008603	28/100	cAMP-dependent protein kinase regulator activity	molecular_function	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]
EOG83V295	GO:0005952	28/100	cAMP-dependent protein kinase complex	cellular_component	"An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732]
EOG83V295	GO:0016301	3/100	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG83V295	GO:0004715	2/100	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG83V295	GO:0007622	1/100	rhythmic behavior	biological_process	"The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr]
EOG83V295	GO:0048149	1/100	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG83V295	GO:0004691	1/100	cAMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11]
EOG83V295	GO:0007623	1/100	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG83V295	GO:0030552	1/100	cAMP binding	molecular_function	"Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai]
EOG83V295	GO:0005737	1/100	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83V295	GO:0045475	1/100	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG83V295	GO:0007411	1/100	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG83V295	GO:0005515	1/100	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG83V295	GO:0048148	1/100	behavioral response to cocaine	biological_process	"Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid]
EOG8WDGRM	GO:0003735	47/309	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8WDGRM	GO:0005840	47/309	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8WDGRM	GO:0006412	47/309	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8WDGRM	GO:0005875	4/309	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8WDGRM	GO:0005634	4/309	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WDGRM	GO:0005829	3/309	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8WDGRM	GO:0003950	3/309	NAD+ ADP-ribosyltransferase activity	molecular_function	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]
EOG8WDGRM	GO:0009987	2/309	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8WDGRM	GO:0022008	1/309	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8WDGRM	GO:0046872	1/309	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WDGRM	GO:2000242	1/309	negative regulation of reproductive process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah]
EOG8WDGRM	GO:0051438	1/309	regulation of ubiquitin-protein transferase activity	biological_process	"Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb]
EOG8WDGRM	GO:0010992	1/309	ubiquitin homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell." [GOC:BHF, GOC:dph, GOC:tb]
EOG8WDGRM	GO:0031386	1/309	protein tag	molecular_function	"Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question." [GOC:go_curators]
EOG8WDGRM	GO:0006464	1/309	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG8WDGRM	GO:0045116	1/309	protein neddylation	biological_process	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]
EOG8WDGRM	GO:0048812	1/309	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8WDGRM	GO:0008283	1/309	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8WDGRM	GO:0007141	1/309	male meiosis I	biological_process	"A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah]
EOG8WDGRM	GO:0048515	1/309	spermatid differentiation	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid]
EOG8WDGRM	GO:0030431	1/309	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8WDGRM	GO:0031647	1/309	regulation of protein stability	biological_process	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]
EOG8WDGRM	GO:0006511	1/309	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8WDGRM	GO:0030162	1/309	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8WDGRM	GO:0008589	1/309	regulation of smoothened signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG8WDGRM	GO:0022625	1/309	cytosolic large ribosomal subunit	cellular_component	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]
EOG8WDGRM	GO:0006909	1/309	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8WDGRM	GO:0008340	1/309	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8GJ237	GO:0016021	48/257	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GJ237	GO:0003917	24/257	DNA topoisomerase type I activity	molecular_function	"Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]
EOG8GJ237	GO:0003677	24/257	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GJ237	GO:0006265	24/257	DNA topological change	biological_process	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]
EOG8GJ237	GO:0005694	23/257	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8GJ237	GO:0008270	22/257	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GJ237	GO:0042246	1/257	tissue regeneration	biological_process	"The regrowth of lost or destroyed tissues." [GOC:curators]
EOG8GJ237	GO:0006909	1/257	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8GJ237	GO:0005739	1/257	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8GJ237	GO:0005634	1/257	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GJ237	GO:0003916	1/257	DNA topoisomerase activity	molecular_function	"Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192]
EOG8GJ237	GO:0005524	1/257	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8GJ237	GO:0050829	1/257	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GJ237	GO:0004185	1/257	serine-type carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8GJ237	GO:0000002	1/257	mitochondrial genome maintenance	biological_process	"The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw]
EOG8GJ237	GO:0048589	1/257	developmental growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]
EOG8GJ237	GO:0005215	1/257	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8GJ237	GO:0035010	1/257	encapsulation of foreign target	biological_process	"Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920]
EOG8GJ237	GO:0000724	1/257	double-strand break repair via homologous recombination	biological_process	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]
EOG83V291	GO:0006396	26/85	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG83V291	GO:0008173	26/85	RNA methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]
EOG83V291	GO:0003723	26/85	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG83V291	GO:0005875	1/85	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8M946D	GO:0008270	2/84	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8M946D	GO:0003682	2/84	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8M946D	GO:0003676	1/84	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M946D	GO:0016853	1/84	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8B5RN4	GO:0005887	1/81	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG873S56	GO:0005891	3/30	voltage-gated calcium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]
EOG873S56	GO:0005245	3/30	voltage-gated calcium channel activity	molecular_function	"Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
EOG8R52M6	GO:0005737	1/2	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8R52M6	GO:0005856	1/2	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8R52M6	GO:0005524	1/2	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8V9X5Z	GO:0005525	23/71	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8V9X5Z	GO:0035998	23/71	7,8-dihydroneopterin 3'-triphosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate." [CHEBI:18372, GOC:yaf, UniPathway:UPA00848]
EOG8V9X5Z	GO:0046872	23/71	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8V9X5Z	GO:0003934	23/71	GTP cyclohydrolase I activity	molecular_function	"Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate." [EC:3.5.4.16]
EOG83R62Q	GO:0003676	55/341	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83R62Q	GO:0005622	1/341	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG83R62Q	GO:0008270	1/341	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83R62Q	GO:0046872	1/341	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83R62Q	GO:0003964	1/341	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG83R62Q	GO:0003723	1/341	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG83R62Q	GO:0042981	1/341	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG898XF3	GO:0045887	1/74	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG898XF3	GO:0046959	1/74	habituation	biological_process	"A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089]
EOG898XF3	GO:0016581	1/74	NuRD complex	cellular_component	"An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569]
EOG898XF3	GO:0005515	1/74	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG898XF3	GO:0060912	1/74	cardiac cell fate specification	biological_process	"The process involved in the specification of cardiac cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:mtg_heart]
EOG898XF3	GO:0005634	1/74	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG898XF3	GO:0000122	1/74	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG880MDW	GO:0003677	5/20	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG880MDW	GO:0003682	1/20	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG873S63	GO:0008270	19/457	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG873S63	GO:0046872	3/457	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG873S63	GO:0016020	1/457	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG873S63	GO:0007165	1/457	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG873S63	GO:0016192	1/457	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8M0HG2	GO:0031418	31/102	L-ascorbic acid binding	molecular_function	"Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]
EOG8M0HG2	GO:0005506	31/102	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8M0HG2	GO:0005783	30/102	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8M0HG2	GO:0016702	30/102	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]
EOG8M0HG2	GO:0004656	30/102	procollagen-proline 4-dioxygenase activity	molecular_function	"Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2]
EOG8M0HG2	GO:0016706	3/102	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG8M0HG4	GO:0005737	1/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8M0HG4	GO:0016322	1/92	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG8M0HG4	GO:0016319	1/92	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8M0HG4	GO:0043277	1/92	apoptotic cell clearance	biological_process	"The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684]
EOG8M0HG4	GO:0005515	1/92	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8V9X5C	GO:0030145	33/94	manganese ion binding	molecular_function	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
EOG8V9X5C	GO:0000287	33/94	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8V9X5C	GO:0006470	29/94	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8V9X5C	GO:0004722	29/94	protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
EOG8V9X5C	GO:0004721	4/94	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8V9X5C	GO:0007476	1/94	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8V9X5C	GO:0001745	1/94	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8V9X5C	GO:0046580	1/94	negative regulation of Ras protein signal transduction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
EOG8V9X5C	GO:0046329	1/94	negative regulation of JNK cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8V9X5C	GO:0007391	1/94	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8V9X5C	GO:0043407	1/94	negative regulation of MAP kinase activity	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]
EOG8V9X5C	GO:0046529	1/94	imaginal disc fusion, thorax closure	biological_process	"The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm]
EOG8V9X5C	GO:0045678	1/94	positive regulation of R7 cell differentiation	biological_process	"Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8V9X5C	GO:1900744	1/94	regulation of p38MAPK cascade	biological_process	"Any process that modulates the frequency, rate or extent of p38MAPK cascade." [GOC:TermGenie]
EOG8V9X5C	GO:1901562	1/94	response to paraquat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus." [GOC:TermGenie]
EOG8V9X5C	GO:0000278	1/94	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8V9X5C	GO:0032873	1/94	negative regulation of stress-activated MAPK cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah]
EOG8V9X5C	GO:0008340	1/94	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8V9X5C	GO:0070303	1/94	negative regulation of stress-activated protein kinase signaling cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade." [GOC:mah]
EOG8V9X5C	GO:0010225	1/94	response to UV-C	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm." [GOC:tb]
EOG8V9X5C	GO:0006979	1/94	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG83R628	GO:0003676	26/225	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83R628	GO:0005634	1/225	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83R628	GO:0046872	1/225	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG873S6G	GO:0016591	13/62	DNA-directed RNA polymerase II, holoenzyme	cellular_component	"Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA." [GOC:jl, PMID:15196470, Wikipedia:Rna_polymerase_ii]
EOG8V9X54	GO:0003682	2/10	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8M0HGC	GO:0016021	35/133	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M0HGC	GO:0005000	29/133	vasopressin receptor activity	molecular_function	"Combining with vasopressin to initiate a change in cell activity." [GOC:ai]
EOG8M0HGC	GO:0004930	6/133	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8M0HGC	GO:0018990	1/133	ecdysis, chitin-based cuticle	biological_process	"The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8M0HGC	GO:0007186	1/133	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8M0HGC	GO:0008188	1/133	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8M0HGC	GO:0007218	1/133	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8M0HGC	GO:0005887	1/133	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V9X56	GO:0004672	1/46	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8V9X56	GO:0005524	1/46	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG873S6J	GO:0016020	23/85	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG873S6J	GO:0016757	22/85	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG873S6J	GO:0033829	1/85	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor." [EC:2.4.1.222]
EOG898XFP	GO:0000151	25/90	ubiquitin ligase complex	cellular_component	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
EOG898XFP	GO:0004842	25/90	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG898XFP	GO:0006950	1/90	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG898XFP	GO:0016567	1/90	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG898XFP	GO:0046983	1/90	protein dimerization activity	molecular_function	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]
EOG8V9X52	GO:0046872	25/44	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8V9X52	GO:0003676	17/44	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V9X52	GO:0005634	3/44	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8V9X52	GO:0001964	1/44	startle response	biological_process	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
EOG8V9X52	GO:0008406	1/44	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG8V9X52	GO:0045476	1/44	nurse cell apoptotic process	biological_process	"Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306]
EOG8V9X52	GO:0045467	1/44	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8V9X52	GO:0045893	1/44	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8V9X52	GO:0006351	1/44	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8V9X52	GO:0007411	1/44	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8V9X52	GO:0003677	1/44	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8V9X52	GO:0022008	1/44	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8V9X52	GO:0019730	1/44	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG8V9X52	GO:0016199	1/44	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG8V9X52	GO:0007409	1/44	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8V9X52	GO:0044719	1/44	regulation of imaginal disc-derived wing size	biological_process	"Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
EOG8V9X52	GO:0003700	1/44	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8V9X52	GO:0005515	1/44	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8V9X52	GO:0048813	1/44	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8V9X52	GO:0002121	1/44	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8V9X52	GO:0007464	1/44	R3/R4 cell fate commitment	biological_process	"The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
EOG8V9X52	GO:0006355	1/44	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8V9X52	GO:0048854	1/44	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG8V9X52	GO:0031987	1/44	locomotion involved in locomotory behavior	biological_process	"Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
EOG896295	GO:0005549	1/3	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8JT2M3	GO:0000166	71/254	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8JT2M3	GO:0003676	65/254	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JT2M3	GO:0030529	4/254	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8JT2M3	GO:0019013	3/254	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8JT2M3	GO:0005737	2/254	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8JT2M3	GO:0003729	2/254	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8JT2M3	GO:0042078	1/254	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG8JT2M3	GO:0017148	1/254	negative regulation of translation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8JT2M3	GO:0048024	1/254	regulation of mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]
EOG8JT2M3	GO:0003697	1/254	single-stranded DNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174]
EOG8JT2M3	GO:0003727	1/254	single-stranded RNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl]
EOG8JT2M3	GO:0046331	1/254	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8JT2M3	GO:0007298	1/254	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8JT2M3	GO:0000900	1/254	translation repressor activity, nucleic acid binding	molecular_function	"Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw]
EOG8JT2M3	GO:0007411	1/254	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8JT2M3	GO:0003723	1/254	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8JT2M3	GO:0048864	1/254	stem cell development	biological_process	"The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete]
EOG8JT2M3	GO:0045182	1/254	translation regulator activity	molecular_function	"Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai]
EOG8JT2M3	GO:0043234	1/254	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8JT2M3	GO:0022416	1/254	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8JT2M3	GO:0005844	1/254	polysome	cellular_component	"A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]
EOG8JT2M3	GO:0005634	1/254	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8JT2M3	GO:0045727	1/254	positive regulation of translation	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8JT2M3	GO:0008266	1/254	poly(U) RNA binding	molecular_function	"Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule." [GOC:mah]
EOG8JT2M3	GO:0003730	1/254	mRNA 3'-UTR binding	molecular_function	"Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah]
EOG8JT2M3	GO:0071456	1/254	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG8JT2M3	GO:0006417	1/254	regulation of translation	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8JT2M3	GO:0019827	1/254	stem cell population maintenance	biological_process	"The process by which an organism or tissue maintains a population of stem cells of a single type.  This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437]
EOG8JT2M3	GO:0005654	1/254	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG8JT2M3	GO:0048027	1/254	mRNA 5'-UTR binding	molecular_function	"Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule." [GOC:jid]
EOG8JT2M3	GO:0007319	1/254	negative regulation of oskar mRNA translation	biological_process	"Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems]
EOG8JT2M3	GO:0001709	1/254	cell fate determination	biological_process	"A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
EOG8JT2M3	GO:0045451	1/254	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8JT2M3	GO:0005515	1/254	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8GF5ZW	GO:0000103	1/2	sulfate assimilation	biological_process	"The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl]
EOG8GF5ZW	GO:0004020	1/2	adenylylsulfate kinase activity	molecular_function	"Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate." [EC:2.7.1.25]
EOG8GF5ZW	GO:0005524	1/2	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8GF5ZW	GO:0070814	1/2	hydrogen sulfide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S." [CHEBI:16136, GOC:mah]
EOG880MD2	GO:0003677	1/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG880MD2	GO:0008113	1/5	peptide-methionine (S)-S-oxide reductase activity	molecular_function	"Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920]
EOG880MD2	GO:0008080	1/5	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG880MD2	GO:0006355	1/5	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG880MD2	GO:0000156	1/5	phosphorelay response regulator activity	molecular_function	"Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140]
EOG854CJ1	GO:0003676	1/2	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG854CJ1	GO:0008270	1/2	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG854CJ1	GO:0004190	1/2	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG898XFG	GO:0005874	4/30	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG898XFG	GO:0005525	4/30	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG898XFG	GO:0051258	4/30	protein polymerization	biological_process	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
EOG898XFG	GO:0007017	4/30	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG898XFG	GO:0003924	4/30	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG898XFG	GO:0005200	4/30	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG898XFG	GO:0003682	1/30	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG898XFG	GO:0003677	1/30	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8H48K0	GO:0008270	3/55	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8H48K0	GO:0006730	3/55	one-carbon metabolic process	biological_process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
EOG8H48K0	GO:0004089	3/55	carbonate dehydratase activity	molecular_function	"Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1]
EOG8M0HGV	GO:0004252	14/19	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8M0HGV	GO:0016787	1/19	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8M0HGV	GO:0006508	1/19	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8TTJXT	GO:0005581	13/81	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8TTJXT	GO:0005201	12/81	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG8M9467	GO:0016117	2/7	carotenoid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators]
EOG8M9467	GO:0016491	1/7	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8M9467	GO:0055114	1/7	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8HX7FQ	GO:0008092	1/100	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8HX7FQ	GO:0001654	1/100	eye development	biological_process	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
EOG8HX7FQ	GO:0042052	1/100	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8HX7FQ	GO:0016013	1/100	syntrophin complex	cellular_component	"A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [http://www.dmd.nl/DGC.html#syn]
EOG8HX7FQ	GO:0008582	1/100	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG83JFN4	GO:0008270	14/61	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83JFN4	GO:0005680	13/61	anaphase-promoting complex	cellular_component	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]
EOG83JFN4	GO:0004842	12/61	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG83JFN4	GO:0031145	1/61	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [PMID:15380083]
EOG83JFN4	GO:0045842	1/61	positive regulation of mitotic metaphase/anaphase transition	biological_process	"Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
EOG83JFN4	GO:0000151	1/61	ubiquitin ligase complex	cellular_component	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
EOG83JFN4	GO:0090302	1/61	APC-Cdc20 complex activity	molecular_function	"A ubiquitin-protein ligase activity that increases the rate or extent of the metaphase to anaphase transition of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
EOG8TTJXP	GO:0004842	8/68	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8TTJXP	GO:0008270	1/68	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83FK9N	GO:0008270	5/46	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83FK9N	GO:0006281	4/46	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG83FK9N	GO:0005634	4/46	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83FK9N	GO:0004842	4/46	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG83FK9N	GO:0003677	4/46	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG83FK9M	GO:0008270	74/433	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83FK9M	GO:0009058	72/433	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG83FK9M	GO:0016491	46/433	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG83FK9M	GO:0016747	38/433	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG83FK9M	GO:0016788	37/433	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG83FK9M	GO:0004313	36/433	[acyl-carrier-protein] S-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38]
EOG83FK9M	GO:0004315	35/433	3-oxoacyl-[acyl-carrier-protein] synthase activity	molecular_function	"Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.41]
EOG83FK9M	GO:0004319	35/433	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	molecular_function	"Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10]
EOG83FK9M	GO:0016295	35/433	myristoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14, MetaCyc:RXN-10727]
EOG83FK9M	GO:0004320	35/433	oleoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14]
EOG83FK9M	GO:0016296	35/433	palmitoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14, MetaCyc:RXN-9549]
EOG83FK9M	GO:0004316	35/433	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
EOG83FK9M	GO:0004314	35/433	[acyl-carrier-protein] S-malonyltransferase activity	molecular_function	"Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39]
EOG83FK9M	GO:0004317	35/433	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.61]
EOG83FK9M	GO:0016740	23/433	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG83FK9M	GO:0004312	19/433	fatty acid synthase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85]
EOG83FK9M	GO:0047451	3/433	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [EC:4.2.1.59, MetaCyc:4.2.1.59-RXN]
EOG83FK9M	GO:0003960	2/433	NADPH:quinone reductase activity	molecular_function	"Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5]
EOG83FK9M	GO:0005811	2/433	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG83FK9M	GO:0050111	1/433	mycocerosate synthase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + 7n H(+) + n methylmalonyl-CoA + 2n NADPH = n CO(2) + n CoA + n H(2)O + multi-methyl-branched acyl-CoA + 2n NADP(+)." [EC:2.3.1.111, RHEA:10591]
EOG841STZ	GO:0004843	1/73	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG841STZ	GO:0003964	1/73	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG841STZ	GO:0006511	1/73	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8TQPRZ	GO:0050660	1/5	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8TQPRZ	GO:0004252	1/5	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8TQPRZ	GO:0016491	1/5	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8TQPRZ	GO:0045454	1/5	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8TQPRD	GO:0005524	1/44	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8TQPRD	GO:0004672	1/44	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG83V29H	GO:0006351	1/5	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG83V29H	GO:0003899	1/5	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG83V29H	GO:0003677	1/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DJNDS	GO:0003723	2/19	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8DJNDS	GO:0008270	2/19	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DJNDS	GO:0003964	2/19	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8DJNDS	GO:0003676	1/19	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DJNDS	GO:0004190	1/19	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG83FK9P	GO:0007605	1/100	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG83FK9P	GO:0050954	1/100	sensory perception of mechanical stimulus	biological_process	"The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG83FK9P	GO:0048813	1/100	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG83FK9P	GO:0031012	1/100	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8HX7FN	GO:0016021	1/87	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PVRCV	GO:0004871	24/95	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8PVRCV	GO:0005634	23/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PVRCV	GO:0003677	22/95	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8PVRCV	GO:0006351	22/95	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8PVRCV	GO:0006355	16/95	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8PVRCV	GO:0005737	7/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8PVRCV	GO:0003700	6/95	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8PVRCV	GO:0005667	6/95	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8PVRCV	GO:0048477	1/95	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8PVRCV	GO:0051726	1/95	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8PVRCV	GO:0010508	1/95	positive regulation of autophagy	biological_process	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8PVRCV	GO:0032869	1/95	cellular response to insulin stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]
EOG8PVRCV	GO:0071456	1/95	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG8PVRCV	GO:0030308	1/95	negative regulation of cell growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8PVRCV	GO:0030334	1/95	regulation of cell migration	biological_process	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]
EOG8PVRCV	GO:0003989	1/95	acetyl-CoA carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2]
EOG8PVRCV	GO:0006974	1/95	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8PVRCV	GO:0060438	1/95	trachea development	biological_process	"The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG8PVRCV	GO:0045944	1/95	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8HDW89	GO:0006810	25/93	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8HDW89	GO:0005622	24/93	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8HDW89	GO:0033206	1/93	meiotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8HDW89	GO:0001700	1/93	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8HDW89	GO:0032154	1/93	cleavage furrow	cellular_component	"In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409]
EOG8HDW89	GO:0031566	1/93	actomyosin contractile ring maintenance	biological_process	"The cell cycle process in which the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures. This process occurs in the context of cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb, GOC:vw]
EOG8HDW89	GO:0005886	1/93	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8HDW89	GO:0007112	1/93	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG8HDW89	GO:0070732	1/93	spindle envelope	cellular_component	"An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase." [GOC:mah, GOC:sart, PMID:19417004, PMID:6428889]
EOG8HDW89	GO:0000916	1/93	actomyosin contractile ring contraction	biological_process	"The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb]
EOG8HDW89	GO:0048137	1/93	spermatocyte division	biological_process	"The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238]
EOG8HDW89	GO:0007111	1/93	meiosis II cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8HDW89	GO:0000915	1/93	actomyosin contractile ring assembly	biological_process	"The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
EOG8HDW89	GO:0005794	1/93	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8HDW89	GO:0043147	1/93	meiotic spindle stabilization	biological_process	"The cell cycle process in which spindle integrity is maintained during M phase of meiosis." [GOC:go_curators]
EOG8HDW89	GO:0007110	1/93	meiosis I cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8HDW89	GO:0016006	1/93	Nebenkern	cellular_component	"A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma]
EOG8HDW89	GO:0031965	1/93	nuclear membrane	cellular_component	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
EOG8HDW84	GO:0006629	11/69	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8GMXBT	GO:0003723	1/10	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8GMXBT	GO:0003964	1/10	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8X3KHJ	GO:0008270	126/815	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X3KHJ	GO:0003676	118/815	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X3KHJ	GO:0003964	12/815	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8X3KHJ	GO:0003723	12/815	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8X3KHJ	GO:0003677	1/815	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X3KHJ	GO:0016192	1/815	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8X3KHJ	GO:0015074	1/815	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8X3KHJ	GO:0016020	1/815	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QC3KD	GO:0005737	1/120	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8QC3KD	GO:0005543	1/120	phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8BZQGD	GO:0032956	28/99	regulation of actin cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]
EOG8BZQGD	GO:0046847	26/99	filopodium assembly	biological_process	"The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790]
EOG8BZQGD	GO:0007165	26/99	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8BZQGD	GO:0016301	5/99	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG82Z746	GO:0005634	4/62	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82Z746	GO:0008270	4/62	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG82Z746	GO:0003677	3/62	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG82Z746	GO:0003676	3/62	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82Z746	GO:0046872	2/62	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8BZQGC	GO:0000956	1/91	nuclear-transcribed mRNA catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]
EOG8GMXBG	GO:0016021	21/124	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GMXBG	GO:0005249	17/124	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8GMXBG	GO:0005216	5/124	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8GMXBG	GO:0008603	2/124	cAMP-dependent protein kinase regulator activity	molecular_function	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]
EOG8GMXBG	GO:0004692	2/124	cGMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
EOG8GMXBG	GO:0005952	2/124	cAMP-dependent protein kinase complex	cellular_component	"An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732]
EOG8GMXBG	GO:0071805	1/124	potassium ion transmembrane transport	biological_process	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
EOG8GMXBG	GO:0045938	1/124	positive regulation of circadian sleep/wake cycle, sleep	biological_process	"Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators]
EOG8GMXBG	GO:0007637	1/124	proboscis extension reflex	biological_process	"The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jid]
EOG8GMXBG	GO:0004691	1/124	cAMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11]
EOG8GMXBG	GO:0004715	1/124	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8GMXBG	GO:0005887	1/124	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GMXBG	GO:0014059	1/124	regulation of dopamine secretion	biological_process	"Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]
EOG8GMXBG	GO:0042391	1/124	regulation of membrane potential	biological_process	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
EOG8GMXBG	GO:0045475	1/124	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8GMXBG	GO:0008340	1/124	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8GMXBG	GO:0050802	1/124	circadian sleep/wake cycle, sleep	biological_process	"The part of the circadian sleep/wake cycle where the organism is asleep." [GOC:ai]
EOG8BZQGZ	GO:0045179	1/95	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8BZQGZ	GO:0035159	1/95	regulation of tube length, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
EOG8BZQGZ	GO:0042067	1/95	establishment of ommatidial planar polarity	biological_process	"The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
EOG8BGCCF	GO:0030246	20/118	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8BGCCF	GO:0016787	2/118	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8BGCCF	GO:0006614	1/118	SRP-dependent cotranslational protein targeting to membrane	biological_process	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]
EOG8BGCCF	GO:0008312	1/118	7S RNA binding	molecular_function	"Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]
EOG8BGCCF	GO:0048500	1/118	signal recognition particle	cellular_component	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]
EOG8BZQGT	GO:0016021	35/146	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BZQGT	GO:0005230	25/146	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8BZQGT	GO:0005886	21/146	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8BZQGT	GO:0006811	10/146	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8BZQGT	GO:1902476	1/146	chloride transmembrane transport	biological_process	"The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw]
EOG8BZQGT	GO:0005254	1/146	chloride channel activity	molecular_function	"Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8BZQGT	GO:0006821	1/146	chloride transport	biological_process	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8BZQGT	GO:0022008	1/146	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8CC6F7	GO:0055085	36/143	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8CC6F7	GO:0016021	36/143	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BGCCB	GO:0000122	5/35	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8BGCCB	GO:0016567	5/35	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8BGCCB	GO:0008270	4/35	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BGCCB	GO:0043066	2/35	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8BGCCB	GO:0071157	2/35	negative regulation of cell cycle arrest	biological_process	"Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases." [GOC:mah]
EOG8BGCCB	GO:0016874	2/35	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8BGCCB	GO:0005634	2/35	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BGCCB	GO:0003676	1/35	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BZQGP	GO:0003676	2/9	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZGRZ9	GO:0003964	5/12	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8ZGRZ9	GO:0003723	5/12	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8ZGRZ9	GO:0004519	1/12	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8CC6FJ	GO:0030659	2/135	cytoplasmic vesicle membrane	cellular_component	"The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]
EOG8CC6FJ	GO:0005856	2/135	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8CC6FJ	GO:0005886	2/135	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8CC6FJ	GO:0048471	2/135	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8CC6FJ	GO:0015031	2/135	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8CC6FJ	GO:0030029	1/135	actin filament-based process	biological_process	"Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah]
EOG8CC6FJ	GO:0045010	1/135	actin nucleation	biological_process	"The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194]
EOG8CC6FJ	GO:0005515	1/135	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8CC6FJ	GO:0045451	1/135	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8CC6FJ	GO:0007315	1/135	pole plasm assembly	biological_process	"Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8CC6FJ	GO:0008017	1/135	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8CC6FJ	GO:0007304	1/135	chorion-containing eggshell formation	biological_process	"The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8CC6FJ	GO:0051639	1/135	actin filament network formation	biological_process	"The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]
EOG8CC6FJ	GO:0005938	1/135	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8CC6FJ	GO:0048477	1/135	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8CC6FJ	GO:0007015	1/135	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8CC6FJ	GO:0005737	1/135	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CC6FJ	GO:0030717	1/135	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG8CC6FJ	GO:0051493	1/135	regulation of cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
EOG8CC6FJ	GO:0003779	1/135	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8CC6FJ	GO:0016192	1/135	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8CC6FJ	GO:0030036	1/135	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8CC6FJ	GO:0007275	1/135	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8CC6FJ	GO:0007316	1/135	pole plasm RNA localization	biological_process	"Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
EOG82Z74Z	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82Z74Z	GO:0022891	1/4	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8CC6FD	GO:0006355	25/87	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8CC6FD	GO:0005634	24/87	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CC6FD	GO:0032783	1/87	ELL-EAF complex	cellular_component	"A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae." [PMID:17150956]
EOG8CC6FD	GO:0005674	1/87	transcription factor TFIIF complex	cellular_component	"A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077]
EOG8CC6FD	GO:0005669	1/87	transcription factor TFIID complex	cellular_component	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]
EOG8CC6FD	GO:0006367	1/87	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG8BGCC4	GO:0004526	16/48	ribonuclease P activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5]
EOG8BGCC4	GO:0005634	16/48	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BGCC4	GO:0008033	16/48	tRNA processing	biological_process	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]
EOG8BGCC4	GO:0003676	15/48	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BGCC4	GO:0005730	1/48	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8BGCC4	GO:0030677	1/48	ribonuclease P complex	cellular_component	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]
EOG8BGCC4	GO:0005737	1/48	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8BGCC4	GO:0030678	1/48	mitochondrial ribonuclease P complex	cellular_component	"A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule." [GOC:mah, PMID:12045094]
EOG8BGCC4	GO:0005515	1/48	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8HMMQG	GO:0046872	2/95	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82Z74S	GO:0000166	57/177	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG82Z74S	GO:0003676	55/177	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82Z74S	GO:0016491	2/177	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG82Z74S	GO:0000381	2/177	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG82Z74S	GO:0003729	2/177	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG82Z74S	GO:0030529	2/177	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG82Z74S	GO:0019013	2/177	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG82Z74S	GO:0005685	1/177	U1 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U1." [GOC:krc, GOC:mah]
EOG82Z74S	GO:0000398	1/177	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG82Z74S	GO:0005634	1/177	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82Z74G	GO:0007156	23/69	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG82Z74G	GO:0005509	23/69	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG82Z74G	GO:0016021	22/69	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82Z74G	GO:0005886	20/69	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG82Z74G	GO:0035003	1/69	subapical complex	cellular_component	"The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938]
EOG82Z74G	GO:0016339	1/69	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
EOG82Z74G	GO:0008360	1/69	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG82Z74G	GO:0005887	1/69	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HMMQP	GO:0005524	1/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8HMMQP	GO:0019538	1/5	protein metabolic process	biological_process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification." [GOC:ma]
EOG8HMMQP	GO:0017111	1/5	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8CC6FP	GO:0050662	21/92	coenzyme binding	molecular_function	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
EOG8CC6FP	GO:0044237	21/92	cellular metabolic process	biological_process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
EOG8CC6FP	GO:0003824	20/92	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8CC6FP	GO:0045226	1/92	extracellular polysaccharide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators]
EOG8CC6FP	GO:0008831	1/92	dTDP-4-dehydrorhamnose reductase activity	molecular_function	"Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.133, RHEA:21799]
EOG8CC6FP	GO:0003954	1/92	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8CC6FP	GO:0008137	1/92	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG82Z74B	GO:0005524	24/82	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82Z74B	GO:0004674	21/82	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG82Z74B	GO:0046872	16/82	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82Z74B	GO:0035556	16/82	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG82Z74B	GO:0004697	3/82	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG82Z74B	GO:0004672	1/82	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG82Z74B	GO:0006468	1/82	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8Q87DB	GO:0016021	27/84	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Q87DB	GO:0006810	26/84	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8Q87DB	GO:0030133	1/84	transport vesicle	cellular_component	"Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]
EOG8Q87DB	GO:0005215	1/84	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8Q87DB	GO:0061357	1/84	positive regulation of Wnt protein secretion	biological_process	"Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
EOG8Q87DB	GO:0048042	1/84	regulation of post-mating oviposition	biological_process	"Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb, PMID:11932766]
EOG8Q87DB	GO:0022008	1/84	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8Q87DB	GO:0048193	1/84	Golgi vesicle transport	biological_process	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG8Q87DB	GO:0000003	1/84	reproduction	biological_process	"The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732]
EOG8HDW8Z	GO:0016772	1/4	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8Z654D	GO:0005198	28/93	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8Z654D	GO:0030130	28/93	clathrin coat of trans-Golgi network vesicle	cellular_component	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]
EOG8Z654D	GO:0030132	28/93	clathrin coat of coated pit	cellular_component	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]
EOG8Z654D	GO:0006886	28/93	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8Z654D	GO:0016192	27/93	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8Z654D	GO:0030136	1/93	clathrin-coated vesicle	cellular_component	"A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]
EOG8Z654D	GO:0030125	1/93	clathrin vesicle coat	cellular_component	"A clathrin coat found on a vesicle." [GOC:mah]
EOG8Z654D	GO:0016183	1/93	synaptic vesicle coating	biological_process	"A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:curators, PMID:10099709]
EOG8Z654D	GO:0008021	1/93	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8Z654D	GO:0030135	1/93	coated vesicle	cellular_component	"Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]
EOG8Z654D	GO:0005905	1/93	coated pit	cellular_component	"A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]
EOG8Z654D	GO:0007269	1/93	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8Z654D	GO:0072583	1/93	clathrin-mediated endocytosis	biological_process	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]
EOG8ZCWJZ	GO:0016773	16/89	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8ZCWJZ	GO:0016491	3/89	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8ZCWJZ	GO:0004454	3/89	ketohexokinase activity	molecular_function	"Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate." [EC:2.7.1.3]
EOG8ZCWJZ	GO:0008927	1/89	mannonate dehydratase activity	molecular_function	"Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.8, RHEA:20100]
EOG8ZCWJZ	GO:0008061	1/89	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8ZCWJZ	GO:0016787	1/89	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8ZCWJZ	GO:0008270	1/89	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZCWJZ	GO:0006030	1/89	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8ZCWJZ	GO:0016829	1/89	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8ZCWJZ	GO:0006064	1/89	glucuronate catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid." [GOC:go_curators]
EOG8ZCWJZ	GO:0005576	1/89	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8ZCWJZ	GO:0030170	1/89	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8N335F	GO:0004190	1/106	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8N335F	GO:0008270	1/106	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8N335F	GO:0003676	1/106	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8J9QDX	GO:0008270	21/100	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8J9QDX	GO:0007291	1/100	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8J9QDX	GO:0070864	1/100	sperm individualization complex	cellular_component	"A macromolecular complex that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst." [GOC:sart, PMID:10588662, PMID:9550716]
EOG8J9QDX	GO:0007279	1/100	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8J9QDX	GO:0005925	1/100	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8J9QDX	GO:0007283	1/100	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8J9QDX	GO:0045856	1/100	positive regulation of pole plasm oskar mRNA localization	biological_process	"Any process that activates or increases the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8J9QDX	GO:0003779	1/100	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8KM1KN	GO:0005840	3/72	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8Z654R	GO:0016021	20/80	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z654R	GO:0016020	1/80	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HDW8F	GO:0006886	37/164	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8HDW8F	GO:0048193	24/164	Golgi vesicle transport	biological_process	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG8HDW8F	GO:0016020	23/164	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HDW8F	GO:0007269	2/164	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8HDW8F	GO:0042147	1/164	retrograde transport, endosome to Golgi	biological_process	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]
EOG8HDW8F	GO:0005886	1/164	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8HDW8F	GO:0016081	1/164	synaptic vesicle docking	biological_process	"The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342]
EOG8HDW8F	GO:0051726	1/164	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8HDW8F	GO:0016021	1/164	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HDW8F	GO:0006906	1/164	vesicle fusion	biological_process	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]
EOG8HDW8F	GO:0016082	1/164	synaptic vesicle priming	biological_process	"The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342]
EOG8HDW8F	GO:0005483	1/164	soluble NSF attachment protein activity	molecular_function	"Interacting selectively and non-covalently with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857]
EOG8HDW8F	GO:0016192	1/164	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8HDW8F	GO:0005737	1/164	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HDW8F	GO:0048190	1/164	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8HDW8F	GO:0005484	1/164	SNAP receptor activity	molecular_function	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
EOG8RNDS4	GO:0005634	23/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RNDS4	GO:0003700	22/92	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8RNDS4	GO:0000976	16/92	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8RNDS4	GO:0043565	7/92	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8RNDS4	GO:0007417	1/92	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8RNDS4	GO:0003677	1/92	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RNDS4	GO:0000122	1/92	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8RNDS4	GO:0030182	1/92	neuron differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
EOG8RNDS4	GO:0006366	1/92	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8RNDS4	GO:0003705	1/92	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG8RNDS4	GO:0010629	1/92	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8RNDS4	GO:0045944	1/92	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8RNDS4	GO:0070491	1/92	repressing transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH]
EOG85F04T	GO:0005525	11/88	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG85F04T	GO:0000184	3/88	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	biological_process	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]
EOG85F04T	GO:0042332	1/88	gravitaxis	biological_process	"The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
EOG85F04T	GO:0005622	1/88	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG88KTWP	GO:0004252	4/4	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG85F04R	GO:0006030	6/11	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG85F04R	GO:0008061	6/11	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG85F04R	GO:0005576	6/11	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8G1PZ8	GO:0046854	27/181	phosphatidylinositol phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]
EOG8G1PZ8	GO:0016881	27/181	acid-amino acid ligase activity	molecular_function	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
EOG8G1PZ8	GO:0052833	3/181	inositol monophosphate 4-phosphatase activity	molecular_function	"Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25]
EOG8G1PZ8	GO:0052832	3/181	inositol monophosphate 3-phosphatase activity	molecular_function	"Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25]
EOG8G1PZ8	GO:0008934	3/181	inositol monophosphate 1-phosphatase activity	molecular_function	"Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25]
EOG8G1PZ8	GO:0046872	2/181	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8G1PZ8	GO:0006021	2/181	inositol biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, ISBN:0198547684]
EOG8G1PZ8	GO:0006661	2/181	phosphatidylinositol biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [CHEBI:28874, ISBN:0198506732]
EOG8G1PZ8	GO:0005737	2/181	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8G1PZ8	GO:0006796	2/181	phosphate-containing compound metabolic process	biological_process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]
EOG8G1PZ8	GO:0007165	2/181	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8G1PZ8	GO:0004842	2/181	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8G1PZ8	GO:0016021	2/181	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G1PZ8	GO:0016311	2/181	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG8G7FFM	GO:0005634	384/651	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8G7FFM	GO:0000786	384/651	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8G7FFM	GO:0003677	384/651	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8G7FFM	GO:0006334	384/651	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8G7FFM	GO:0005811	50/651	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8G7FFM	GO:0051298	17/651	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8G7FFM	GO:0006281	1/651	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8G7FFM	GO:0005701	1/651	polytene chromosome chromocenter	cellular_component	"A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012]
EOG8G7FFM	GO:0071168	1/651	protein localization to chromatin	biological_process	"Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah]
EOG8G7FFM	GO:0005700	1/651	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8G7FFM	GO:0006974	1/651	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8G7FFM	GO:0005694	1/651	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8G7FFM	GO:0007275	1/651	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8J9QF2	GO:0006351	1/21	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8J9QF2	GO:0003677	1/21	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8J9QF2	GO:0003899	1/21	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8SN439	GO:0008270	23/92	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SN439	GO:0016021	1/92	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SN439	GO:0016881	1/92	acid-amino acid ligase activity	molecular_function	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
EOG8SN439	GO:0005515	1/92	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8SN439	GO:0004842	1/92	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8SN439	GO:0030968	1/92	endoplasmic reticulum unfolded protein response	biological_process	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]
EOG8SN439	GO:0005783	1/92	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8SN439	GO:0016567	1/92	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8SN439	GO:0002039	1/92	p53 binding	molecular_function	"Interacting selectively and non-covalently with one of the p53 family of proteins." [GOC:hjd]
EOG8SN439	GO:0005789	1/92	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8SN439	GO:0016874	1/92	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8SN439	GO:0030433	1/92	ER-associated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]
EOG8JHFX2	GO:0016491	25/129	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8JHFX2	GO:0004316	21/129	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
EOG8JHFX2	GO:0004303	5/129	estradiol 17-beta-dehydrogenase activity	molecular_function	"Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62]
EOG8JHFX7	GO:0003676	22/75	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG815JT8	GO:0005272	1/88	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG815JT8	GO:0016020	1/88	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG815JT8	GO:0016874	1/88	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG815JT8	GO:0007605	1/88	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG85F04N	GO:0016021	2/35	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G7FFX	GO:0003676	4/30	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85XB9P	GO:0004531	31/91	deoxyribonuclease II activity	molecular_function	"Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1]
EOG85XB9P	GO:0005622	1/91	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG85XB9P	GO:0006308	1/91	DNA catabolic process	biological_process	"The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732]
EOG85XB9P	GO:0045476	1/91	nurse cell apoptotic process	biological_process	"Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306]
EOG85XB9P	GO:0006309	1/91	apoptotic DNA fragmentation	biological_process	"The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520]
EOG8N06V7	GO:0003676	9/45	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8N06V7	GO:0015074	8/45	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8N06V7	GO:0003964	5/45	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8N06V7	GO:0003723	5/45	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8N06V7	GO:0008270	3/45	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8N06V7	GO:0004190	2/45	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8N06V7	GO:0003677	1/45	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8N06V7	GO:0006310	1/45	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8N06V9	GO:0016747	176/428	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8N06V9	GO:0022416	1/428	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8N06V9	GO:0035220	1/428	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8P5NRS	GO:0008270	2/159	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8P5NRS	GO:0003712	1/159	transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8P5NRS	GO:0004402	1/159	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8P5NRS	GO:0003677	1/159	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8P5NRS	GO:0005634	1/159	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8P5NRS	GO:0006355	1/159	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8P5NRX	GO:0008270	66/179	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8P5NRX	GO:0005634	2/179	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8P5NRX	GO:0032183	1/179	SUMO binding	molecular_function	"Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO." [GOC:mah]
EOG8P5NRX	GO:0045893	1/179	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8P5NRX	GO:0004842	1/179	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8P5NRX	GO:0070201	1/179	regulation of establishment of protein localization	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah]
EOG8P5NRX	GO:0016567	1/179	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8P5NRX	GO:0005737	1/179	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8P5NRX	GO:0033768	1/179	SUMO-targeted ubiquitin ligase complex	cellular_component	"A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes." [GOC:vw, PMID:17762864, PMID:17762865]
EOG8P5NRX	GO:0007530	1/179	sex determination	biological_process	"Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732]
EOG8P5NRX	GO:0001103	1/179	RNA polymerase II repressing transcription factor binding	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription." [GOC:txnOH]
EOG8P5NRX	GO:0043393	1/179	regulation of protein binding	biological_process	"Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators]
EOG8P5NRX	GO:0022008	1/179	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG869T7W	GO:0005730	1/72	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8N06VB	GO:0030054	17/57	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8N06VB	GO:0007268	17/57	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8N06VB	GO:0005856	17/57	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8N06VB	GO:0008270	17/57	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8N06VB	GO:0045211	17/57	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8N06VG	GO:0005622	23/87	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8N06VG	GO:0005856	1/87	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8N06VG	GO:0005546	1/87	phosphatidylinositol-4,5-bisphosphate binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]
EOG8N06VG	GO:0051015	1/87	actin filament binding	molecular_function	"Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]
EOG8N06VG	GO:0005547	1/87	phosphatidylinositol-3,4,5-trisphosphate binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl]
EOG8N06VG	GO:0005737	1/87	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8N06VG	GO:0022416	1/87	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8N06VG	GO:0001786	1/87	phosphatidylserine binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]
EOG8N06VG	GO:0016301	1/87	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8N06VG	GO:0003779	1/87	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG815JTB	GO:0006826	6/50	iron ion transport	biological_process	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG815JTB	GO:0008199	6/50	ferric iron binding	molecular_function	"Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai]
EOG815JTB	GO:0005576	6/50	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG815JTB	GO:0006879	6/50	cellular iron ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah]
EOG815JTG	GO:0010587	6/91	miRNA catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]
EOG815JTG	GO:0003723	6/91	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG815JTG	GO:0000175	6/91	3'-5'-exoribonuclease activity	molecular_function	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]
EOG815JTG	GO:0034427	6/91	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	biological_process	"The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [GOC:krc, GOC:mah]
EOG815JTG	GO:1990074	6/91	polyuridylation-dependent mRNA catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end of the target mRNA." [GOC:vw, PMID:23503588]
EOG815JTG	GO:0000932	6/91	cytoplasmic mRNA processing body	cellular_component	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603]
EOG815JTG	GO:0008859	2/91	exoribonuclease II activity	molecular_function	"Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684]
EOG815JTG	GO:0004527	1/91	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8J9QFZ	GO:0019028	86/300	viral capsid	cellular_component	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
EOG85TG4K	GO:0007018	1/87	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG85TG4K	GO:0006200	1/87	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG85TG4K	GO:0048813	1/87	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG85TG4K	GO:0016319	1/87	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG85TG4K	GO:0042623	1/87	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG85TG4K	GO:0005875	1/87	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG85TG4K	GO:0030286	1/87	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8STVK6	GO:0004871	4/28	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8STVK6	GO:0016020	3/28	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8STVK6	GO:0016021	2/28	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8STVK6	GO:0004888	1/28	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8STVK6	GO:0005506	1/28	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8STVK6	GO:0006935	1/28	chemotaxis	biological_process	"The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732]
EOG8STVK6	GO:0020037	1/28	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8STVK6	GO:0009055	1/28	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8STVK6	GO:0005215	1/28	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8JHFXN	GO:0008887	1/4	glycerate kinase activity	molecular_function	"Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H(+)." [EC:2.7.1.31, RHEA:23519]
EOG8JHFXN	GO:0031388	1/4	organic acid phosphorylation	biological_process	"The process of introducing one or more phosphate groups into an organic acid." [GOC:mah]
EOG88KTW8	GO:0055085	1/2	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG88KTW8	GO:0016021	1/2	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G7FF7	GO:0008233	1/67	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8G7FF7	GO:0007521	1/67	muscle cell fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators]
EOG8G7FF7	GO:0005576	1/67	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8JHFXW	GO:0016818	1/5	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	molecular_function	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]
EOG8JHFXW	GO:0006355	1/5	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8JHFXW	GO:0005634	1/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8JHFXW	GO:0003677	1/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8JHFXW	GO:0005524	1/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8JHFXW	GO:0008270	1/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84XMWW	GO:0005549	1/90	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG84XMWW	GO:0016020	1/90	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG84XMWW	GO:0006909	1/90	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG84XMWW	GO:0004984	1/90	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG84XMWW	GO:0016021	1/90	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86HJRC	GO:0009401	4/21	phosphoenolpyruvate-dependent sugar phosphotransferase system	biological_process	"The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html]
EOG86HJRC	GO:0005351	4/21	sugar:proton symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]
EOG86HJRC	GO:0016020	3/21	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG86HJRC	GO:0008982	2/21	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	molecular_function	"Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-]
EOG86HJRC	GO:0004553	1/21	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG86HJRC	GO:0005975	1/21	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG86HJRC	GO:0005886	1/21	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8RV55R	GO:0008270	21/75	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RV55R	GO:0000381	1/75	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8RV55R	GO:0005634	1/75	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82RGNQ	GO:0004096	47/133	catalase activity	molecular_function	"Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6]
EOG82RGNQ	GO:0020037	47/133	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG82RGNQ	GO:0046872	40/133	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82RGNQ	GO:0006979	26/133	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG82RGNQ	GO:0042744	21/133	hydrogen peroxide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]
EOG82RGNQ	GO:0007568	1/133	aging	biological_process	"A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death (GO:0016265) and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators]
EOG82RGNQ	GO:0042542	1/133	response to hydrogen peroxide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]
EOG82RGNQ	GO:0016209	1/133	antioxidant activity	molecular_function	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
EOG82RGNQ	GO:0005777	1/133	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG82RGNQ	GO:0035206	1/133	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG82RGNQ	GO:0008340	1/133	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8RV55X	GO:0006396	22/92	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8RV55X	GO:0008173	22/92	RNA methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]
EOG8RV55X	GO:0003723	22/92	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RV55X	GO:0008270	1/92	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RV55X	GO:0003676	1/92	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RV55D	GO:0060361	1/91	flight	biological_process	"Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph]
EOG8RV55D	GO:0008328	1/91	ionotropic glutamate receptor complex	cellular_component	"A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
EOG8RV55D	GO:0097106	1/91	postsynaptic density organization	biological_process	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse." [GOC:BHF, GOC:sjp, PMID:21525273]
EOG8RV55D	GO:0007528	1/91	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8RV55D	GO:0007274	1/91	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8RV55D	GO:0097482	1/91	muscle cell postsynaptic density	cellular_component	"A postsynaptic density that is part of a muscle cell." [GOC:pr]
EOG8RV55D	GO:0035187	1/91	hatching behavior	biological_process	"The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [GOC:pr, PMID:10436051]
EOG8RV55D	GO:0046331	1/91	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8RV55D	GO:0051726	1/91	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8RV55D	GO:0043113	1/91	receptor clustering	biological_process	"The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460]
EOG8RV55D	GO:0040011	1/91	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG8RV55D	GO:0031594	1/91	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG837TTS	GO:0007219	27/89	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG837TTS	GO:0004222	27/89	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG837TTS	GO:0006509	27/89	membrane protein ectodomain proteolysis	biological_process	"The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/]
EOG837TTS	GO:0008270	18/89	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG837TTS	GO:0030516	1/89	regulation of axon extension	biological_process	"Any process that modulates the rate, direction or extent of axon extension." [GOC:go_curators]
EOG837TTS	GO:0006909	1/89	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG837TTS	GO:0060537	1/89	muscle tissue development	biological_process	"The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]
EOG837TTS	GO:0035386	1/89	regulation of Roundabout signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF]
EOG837TTS	GO:0048542	1/89	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG837TTS	GO:0061320	1/89	pericardial nephrocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]
EOG837TTS	GO:0008347	1/89	glial cell migration	biological_process	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
EOG837TTS	GO:0007229	1/89	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG837TTS	GO:0035051	1/89	cardiocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf]
EOG837TTS	GO:0048477	1/89	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG837TTS	GO:0007298	1/89	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG837TTS	GO:0007400	1/89	neuroblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
EOG837TTS	GO:0007411	1/89	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG837TTS	GO:0007417	1/89	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG837TTS	GO:0007519	1/89	skeletal muscle tissue development	biological_process	"The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
EOG837TTS	GO:0003007	1/89	heart morphogenesis	biological_process	"The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]
EOG837TTS	GO:0007220	1/89	Notch receptor processing	biological_process	"The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]
EOG8BGC9P	GO:0000079	16/111	regulation of cyclin-dependent protein serine/threonine kinase activity	biological_process	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]
EOG8BGC9P	GO:0005634	15/111	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BGC9P	GO:0007049	14/111	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG8BGC9P	GO:0051301	14/111	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8BGC9P	GO:0003950	6/111	NAD+ ADP-ribosyltransferase activity	molecular_function	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]
EOG8BGC9P	GO:0016787	2/111	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG870WZW	GO:0006950	6/101	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG870WZW	GO:0030018	1/101	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG83XXJM	GO:0016021	12/54	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83XXJM	GO:0004930	7/54	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG83XXJM	GO:0004983	5/54	neuropeptide Y receptor activity	molecular_function	"Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
EOG83XXJM	GO:0050254	2/54	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG87M4F5	GO:0005506	1/39	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG87M4F5	GO:0016705	1/39	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG87M4F5	GO:0020037	1/39	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG83XXJC	GO:0016740	3/372	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG83XXJC	GO:0005634	1/372	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83XXJC	GO:0008168	1/372	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG83XXJC	GO:0008270	1/372	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83XXJC	GO:0022008	1/372	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG83XXJC	GO:0005737	1/372	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87WR4F	GO:0006913	26/92	nucleocytoplasmic transport	biological_process	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]
EOG87WR4F	GO:0005643	26/92	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG87WR4F	GO:0051028	1/92	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG87WR4F	GO:0015031	1/92	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG87WR4F	GO:0005487	1/92	nucleocytoplasmic transporter activity	molecular_function	"Enables the directed movement of substances between the nucleus and the cytoplasm of a cell." [GOC:ai]
EOG87WR4F	GO:0048812	1/92	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8S4RW9	GO:0005856	28/109	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8S4RW9	GO:0007165	20/109	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8CNT55	GO:0005524	1/6	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CNT55	GO:0016887	1/6	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8RJJGV	GO:0005525	49/162	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8RJJGV	GO:0007264	49/162	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8RJJGV	GO:0015031	47/162	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8RJJGV	GO:0003924	2/162	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8RJJGV	GO:0055037	2/162	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG8RJJGV	GO:0043025	2/162	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8RJJGV	GO:0006184	2/162	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8RJJGV	GO:0045202	2/162	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8RJJGV	GO:0004767	1/162	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8RJJGV	GO:0045175	1/162	basal protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf]
EOG8RJJGV	GO:0005737	1/162	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RJJGV	GO:0008021	1/162	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8RJJGV	GO:0046331	1/162	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8RJJGV	GO:0031254	1/162	cell trailing edge	cellular_component	"The area of a motile cell opposite to the direction of movement." [GOC:pg]
EOG8RJJGV	GO:0007295	1/162	growth of a germarium-derived egg chamber	biological_process	"Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8RJJGV	GO:0045178	1/162	basal part of cell	cellular_component	"The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194]
EOG8CNT58	GO:0016787	42/138	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8CNT58	GO:0006470	3/138	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8CNT58	GO:0046872	3/138	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CNT58	GO:0004722	3/138	protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
EOG8CNT58	GO:0030431	3/138	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8CNT58	GO:0004723	2/138	calcium-dependent protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [EC:3.1.3.16, GOC:mah]
EOG8CNT58	GO:0033192	2/138	calmodulin-dependent protein phosphatase activity	molecular_function	"Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:15359118]
EOG8CNT58	GO:0005515	2/138	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8CNT58	GO:0005955	2/138	calcineurin complex	cellular_component	"A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [ISBN:019859951]
EOG8CNT58	GO:0007126	1/138	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8CNT58	GO:0051533	1/138	positive regulation of NFAT protein import into nucleus	biological_process	"Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai]
EOG8CNT58	GO:0016192	1/138	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8CNT58	GO:0008021	1/138	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8CNT58	GO:0007269	1/138	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8CNT58	GO:0035220	1/138	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8CNT58	GO:0005516	1/138	calmodulin binding	molecular_function	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
EOG8CNT58	GO:0072375	1/138	medium-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster)." [GOC:sart, PMID:14659098, PMID:7923375]
EOG8CNT58	GO:0004721	1/138	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8CNT58	GO:0007143	1/138	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG870WZN	GO:0005524	52/162	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG870WZN	GO:0016226	48/162	iron-sulfur cluster assembly	biological_process	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]
EOG870WZN	GO:0051539	48/162	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG870WZN	GO:0046872	48/162	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG870WZN	GO:0005737	33/162	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG870WZN	GO:0005829	15/162	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG870WZN	GO:0051536	15/162	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG870WZN	GO:0017111	11/162	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8GTNT2	GO:0005634	24/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GTNT2	GO:0003700	1/90	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8GTNT2	GO:0043565	1/90	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8GTNT0	GO:0003676	5/105	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GTNT0	GO:0015074	4/105	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8GTNT0	GO:0008270	2/105	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BGC91	GO:0008236	1/34	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8BGC91	GO:0016020	1/34	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8BGC91	GO:0007229	1/34	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG8003Z8	GO:0005856	26/105	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8003Z8	GO:0005198	22/105	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8003Z8	GO:0019898	16/105	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8003Z8	GO:0005737	16/105	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8003Z8	GO:0061343	1/105	cell adhesion involved in heart morphogenesis	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
EOG8003Z8	GO:0005886	1/105	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8003Z8	GO:0005918	1/105	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG8003Z8	GO:0035151	1/105	regulation of tube size, open tracheal system	biological_process	"Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]
EOG8003Z8	GO:0007163	1/105	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8003Z8	GO:0006612	1/105	protein targeting to membrane	biological_process	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]
EOG8003Z8	GO:0019991	1/105	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG8003Z8	GO:0008362	1/105	chitin-based embryonic cuticle biosynthetic process	biological_process	"Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232]
EOG8003Z8	GO:0045216	1/105	cell-cell junction organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8003Z8	GO:0035321	1/105	maintenance of imaginal disc-derived wing hair orientation	biological_process	"Ensuring that hairs in the imaginal disc-derived wing continue to point distally during development, following the initial establishment of wing hair polarity." [GOC:mtg_sensu, PMID:15501220]
EOG8003Z8	GO:0007527	1/105	adult somatic muscle development	biological_process	"The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG8003Z8	GO:0009790	1/105	embryo development	biological_process	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
EOG8003Z8	GO:0005920	1/105	smooth septate junction	cellular_component	"A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298]
EOG8003Z8	GO:0008092	1/105	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8003Z8	GO:0060857	1/105	establishment of glial blood-brain barrier	biological_process	"Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
EOG8003Z8	GO:0007391	1/105	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8003Z8	GO:0003015	1/105	heart process	biological_process	"A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]
EOG8003Z8	GO:0007435	1/105	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8GTNTK	GO:0003676	21/61	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GTNTK	GO:0046872	21/61	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GTNTH	GO:0046872	1/33	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GTNTH	GO:0008270	1/33	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GTNTH	GO:0005634	1/33	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GTNTH	GO:0019867	1/33	outer membrane	cellular_component	"The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators]
EOG8CNT5M	GO:0007165	8/439	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8CNT5M	GO:0016021	1/439	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CNT5M	GO:0022891	1/439	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8CNT5M	GO:0006909	1/439	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8CNT5M	GO:0035330	1/439	regulation of hippo signaling	biological_process	"Any process that modulates the frequency, rate or extent of hippo signaling." [GOC:bf]
EOG8CNT5M	GO:0031410	1/439	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG85HVB4	GO:0005524	22/117	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG85HVB4	GO:0005634	22/117	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85HVB4	GO:0004386	22/117	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG85HVB4	GO:0003677	21/117	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG85HVB4	GO:0016817	5/117	hydrolase activity, acting on acid anhydrides	molecular_function	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]
EOG85HVB4	GO:0003682	5/117	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG85HVB4	GO:0016887	1/117	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG85HVB4	GO:0003676	1/117	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83XXJ8	GO:0016787	29/77	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG83XXJ8	GO:0004067	5/77	asparaginase activity	molecular_function	"Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]
EOG83XXJ8	GO:0033345	2/77	asparagine catabolic process via L-aspartate	biological_process	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]
EOG83XXJ8	GO:0008798	2/77	beta-aspartyl-peptidase activity	molecular_function	"Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide." [EC:3.4.19.5]
EOG83XXJ8	GO:0005737	2/77	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83XXJ8	GO:0003948	2/77	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	molecular_function	"Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)." [EC:3.5.1.26, RHEA:11547]
EOG83XXJ8	GO:0035071	1/77	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG83XXJ8	GO:0048102	1/77	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8DFS3K	GO:0030170	1/5	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8DFS3K	GO:0006534	1/5	cysteine metabolic process	biological_process	"The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]
EOG8DFS3K	GO:0031071	1/5	cysteine desulfurase activity	molecular_function	"Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7]
EOG83XXJ5	GO:0006511	23/108	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG83XXJ5	GO:0008234	16/108	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG83XXJ5	GO:0004221	2/108	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG83XXJ5	GO:0045880	1/108	positive regulation of smoothened signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG83XXJ5	GO:0016579	1/108	protein deubiquitination	biological_process	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]
EOG83XXJ5	GO:0008587	1/108	imaginal disc-derived wing margin morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG83XXJ5	GO:0090263	1/108	positive regulation of canonical Wnt signaling pathway	biological_process	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]
EOG83XXJ5	GO:0005737	1/108	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83XXJ5	GO:0004843	1/108	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG8FTZHR	GO:0016301	1/8	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8RV553	GO:0005634	1/98	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RV553	GO:0051536	1/98	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8RV553	GO:0008233	1/98	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8RV553	GO:0005198	1/98	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8RV553	GO:0016226	1/98	iron-sulfur cluster assembly	biological_process	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]
EOG8HHRKW	GO:0005576	2/101	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8HHRKW	GO:0008233	2/101	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8HHRKW	GO:0005215	2/101	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8HHRKW	GO:0048190	1/101	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8HHRKW	GO:0030178	1/101	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8JDKMK	GO:0004252	28/105	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8JDKMK	GO:0004714	1/105	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8JDKMK	GO:0016021	1/105	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JDKMK	GO:0005886	1/105	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8V45NG	GO:0016021	2/124	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V45NG	GO:0016301	1/124	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8V45NF	GO:0046872	1/73	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8R7XR6	GO:0004871	26/101	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8R7XR6	GO:0005525	26/101	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8R7XR6	GO:0003924	26/101	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8R7XR6	GO:0007186	25/101	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8R7XR6	GO:0046872	3/101	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8R7XR6	GO:0005834	2/101	heterotrimeric G-protein complex	cellular_component	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684]
EOG8R7XR6	GO:0007191	2/101	adenylate cyclase-activating dopamine receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling]
EOG8R7XR6	GO:0007476	2/101	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8R7XR6	GO:0031234	2/101	extrinsic component of cytoplasmic side of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah]
EOG8R7XR6	GO:0001664	2/101	G-protein coupled receptor binding	molecular_function	"Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph]
EOG8R7XR6	GO:0031683	2/101	G-protein beta/gamma-subunit complex binding	molecular_function	"Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]
EOG8R7XR6	GO:0007268	2/101	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8R7XR6	GO:0005886	2/101	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8R7XR6	GO:0007528	2/101	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8R7XR6	GO:0035220	1/101	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8R7XR6	GO:0007608	1/101	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8R7XR6	GO:0007606	1/101	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8R7XR6	GO:0007611	1/101	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG8R7XR6	GO:0050916	1/101	sensory perception of sweet taste	biological_process	"The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8R7XR6	GO:0010353	1/101	response to trehalose	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512]
EOG8R7XR6	GO:0005604	1/101	basement membrane	cellular_component	"A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]
EOG8R7XR6	GO:0002165	1/101	instar larval or pupal development	biological_process	"The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
EOG8R7XR6	GO:0022416	1/101	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8R7XR6	GO:0048148	1/101	behavioral response to cocaine	biological_process	"Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid]
EOG8R7XR6	GO:0007632	1/101	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG8R7XR6	GO:2000253	1/101	positive regulation of feeding behavior	biological_process	"Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol]
EOG8R7XR3	GO:0055085	46/146	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8R7XR3	GO:0016021	46/146	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG869TC0	GO:0004190	1/88	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8STVKR	GO:0003676	4/38	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JDKMP	GO:0004622	1/67	lysophospholipase activity	molecular_function	"Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5]
EOG8JDKMP	GO:0048812	1/67	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8JDKMQ	GO:0007165	23/94	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8JDKMQ	GO:0005622	22/94	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8JDKMQ	GO:0005096	18/94	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8JDKMQ	GO:0043547	1/94	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8JDKMQ	GO:0032312	1/94	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8JDKMQ	GO:0007480	1/94	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8JDKMQ	GO:0008060	1/94	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8M67XK	GO:0005198	1/50	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8M67XK	GO:0006890	1/50	retrograde vesicle-mediated transport, Golgi to ER	biological_process	"The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524]
EOG8JDKMV	GO:0008063	1/90	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8JDKMV	GO:0005121	1/90	Toll binding	molecular_function	"Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb]
EOG8JDKMV	GO:0005576	1/90	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8K0T51	GO:0004523	3/22	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8K0T51	GO:0003964	2/22	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8K0T51	GO:0003723	2/22	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8K0T51	GO:0003676	1/22	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SBHCV	GO:0005524	16/97	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SBHCV	GO:0004672	15/97	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8SBHCV	GO:0016772	2/97	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8SBHCV	GO:0005634	1/97	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SBHCV	GO:0004674	1/97	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8SBHCV	GO:0006468	1/97	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8SBHCV	GO:0035556	1/97	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8HX7GP	GO:0004417	2/6	hydroxyethylthiazole kinase activity	molecular_function	"Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+)." [EC:2.7.1.50, RHEA:24215]
EOG8HX7GP	GO:0009228	2/6	thiamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [CHEBI:18385, GOC:jl, ISBN:0198506732]
EOG8HX7GP	GO:0008972	2/6	phosphomethylpyrimidine kinase activity	molecular_function	"Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine." [EC:2.7.4.7]
EOG89KJ5B	GO:0035556	19/128	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG89KJ5B	GO:0046872	17/128	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8G4K53	GO:0005886	1/80	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8G4K53	GO:0042063	1/80	gliogenesis	biological_process	"The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid]
EOG8G4K53	GO:0007409	1/80	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8G4K53	GO:0007399	1/80	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8G4K53	GO:0019897	1/80	extrinsic component of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]
EOG85XB93	GO:0006886	15/115	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG85XB93	GO:0016192	15/115	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG85XB93	GO:0030117	15/115	membrane coat	cellular_component	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]
EOG85XB93	GO:0007367	4/115	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG85XB93	GO:0045296	4/115	cadherin binding	molecular_function	"Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]
EOG85XB93	GO:0008134	3/115	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG85XB93	GO:0014017	3/115	neuroblast fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585]
EOG85XB93	GO:0005912	3/115	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG85XB93	GO:0016055	3/115	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG85XB93	GO:0007155	3/115	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG85XB93	GO:0030057	2/115	desmosome	cellular_component	"A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181]
EOG85XB93	GO:0005667	2/115	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG85XB93	GO:0003713	2/115	transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG85XB93	GO:0016342	2/115	catenin complex	cellular_component	"Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323]
EOG85XB93	GO:0005916	2/115	fascia adherens	cellular_component	"A cell-cell adherens junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:mtg_muscle, PMID:11732910]
EOG85XB93	GO:0005829	2/115	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG85XB93	GO:0005886	2/115	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG85XB93	GO:0005198	2/115	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG85XB93	GO:0005915	2/115	zonula adherens	cellular_component	"A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208]
EOG85XB93	GO:0003136	2/115	negative regulation of heart induction by canonical Wnt signaling pathway	biological_process	"Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329]
EOG85XB93	GO:0019901	2/115	protein kinase binding	molecular_function	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]
EOG85XB93	GO:0048599	2/115	oocyte development	biological_process	"The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators]
EOG85XB93	GO:0009898	2/115	cytoplasmic side of plasma membrane	cellular_component	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]
EOG85XB93	GO:0007399	2/115	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG85XB93	GO:0045294	2/115	alpha-catenin binding	molecular_function	"Interacting selectively and non-covalently with the alpha subunit of the catenin complex." [GOC:bf]
EOG85XB93	GO:0000902	2/115	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG85XB93	GO:0016337	2/115	single organismal cell-cell adhesion	biological_process	"The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb]
EOG85XB93	GO:0007016	2/115	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG85XB93	GO:0030018	2/115	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG85XB93	GO:0016323	2/115	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG85XB93	GO:0000122	2/115	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG85XB93	GO:0016324	1/115	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG85XB93	GO:0001745	1/115	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG85XB93	GO:0060914	1/115	heart formation	biological_process	"The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart]
EOG85XB93	GO:0035147	1/115	branch fusion, open tracheal system	biological_process	"Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584]
EOG85XB93	GO:0008360	1/115	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG85XB93	GO:0030720	1/115	oocyte localization involved in germarium-derived egg chamber formation	biological_process	"Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356]
EOG85XB93	GO:0071896	1/115	protein localization to adherens junction	biological_process	"Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:BHF, GOC:mah]
EOG85XB93	GO:0035293	1/115	chitin-based larval cuticle pattern formation	biological_process	"The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG85XB93	GO:0048477	1/115	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG85XB93	GO:0016327	1/115	apicolateral plasma membrane	cellular_component	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
EOG85XB93	GO:0045186	1/115	zonula adherens assembly	biological_process	"Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf]
EOG85XB93	GO:0048754	1/115	branching morphogenesis of an epithelial tube	biological_process	"The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid]
EOG85XB93	GO:0007507	1/115	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG85XB93	GO:0035019	1/115	somatic stem cell population maintenance	biological_process	"Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089]
EOG85XB93	GO:0019900	1/115	kinase binding	molecular_function	"Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]
EOG85XB93	GO:0072659	1/115	protein localization to plasma membrane	biological_process	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]
EOG85XB93	GO:0035017	1/115	cuticle pattern formation	biological_process	"The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf]
EOG85XB93	GO:0048526	1/115	imaginal disc-derived wing expansion	biological_process	"The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing." [GOC:mtg_sensu, GOC:rc]
EOG85XB93	GO:0007163	1/115	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG85XB93	GO:0014019	1/115	neuroblast development	biological_process	"The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585]
EOG85XB93	GO:0007370	1/115	ventral furrow formation	biological_process	"Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238]
EOG85XB93	GO:0030139	1/115	endocytic vesicle	cellular_component	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]
EOG85XB93	GO:0007391	1/115	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG85XB93	GO:0032403	1/115	protein complex binding	molecular_function	"Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:mah]
EOG85XB93	GO:0005737	1/115	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG85XB93	GO:0005914	1/115	spot adherens junction	cellular_component	"A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298]
EOG85XB93	GO:0007472	1/115	wing disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG85XB93	GO:0005634	1/115	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85XB93	GO:0007616	1/115	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG85XB93	GO:0045944	1/115	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG85XB93	GO:0008092	1/115	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG85XB93	GO:0046530	1/115	photoreceptor cell differentiation	biological_process	"The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732]
EOG85XB93	GO:0030707	1/115	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG85XB93	GO:0045893	1/115	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85XB93	GO:0035153	1/115	epithelial cell type specification, open tracheal system	biological_process	"Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940]
EOG85XB93	GO:0060232	1/115	delamination	biological_process	"The process of negative regulation of cell adhesion that results in a cell or sheet of cells splitting off from an existing epithelial sheet." [GOC:dph, PMID:16962574, PMID:18343170]
EOG85XB93	GO:0046667	1/115	compound eye retinal cell programmed cell death	biological_process	"Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672]
EOG85XB93	GO:0016331	1/115	morphogenesis of embryonic epithelium	biological_process	"The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl]
EOG85XB93	GO:0030424	1/115	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG85XB93	GO:0007369	1/115	gastrulation	biological_process	"A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]
EOG85XB93	GO:0005515	1/115	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG85XB93	GO:0001709	1/115	cell fate determination	biological_process	"A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
EOG85XB96	GO:0046872	24/98	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85XB96	GO:0005524	24/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG85XB96	GO:0035556	23/98	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG85XB96	GO:0004713	13/98	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG85XB96	GO:0004674	11/98	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG85XB96	GO:0008293	1/98	torso signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
EOG85XB96	GO:0004672	1/98	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG85XB96	GO:0008595	1/98	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG85XB96	GO:0007165	1/98	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG85XB96	GO:0007426	1/98	tracheal outgrowth, open tracheal system	biological_process	"The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG85XB96	GO:0006468	1/98	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG85XB96	GO:0004715	1/98	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG85XB96	GO:0007476	1/98	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG85XB96	GO:0007265	1/98	Ras protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf]
EOG85XB9J	GO:0048812	1/87	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG85XB9J	GO:0035005	1/87	1-phosphatidylinositol-4-phosphate 3-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.154, RHEA:18376]
EOG85XB9K	GO:0005578	143/527	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG85XB9K	GO:0016055	142/527	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG85XB9K	GO:0007275	138/527	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG85XB9K	GO:0005109	5/527	frizzled binding	molecular_function	"Interacting selectively and non-covalently with the frizzled (fz) receptor." [GOC:ceb, PR:000001315]
EOG85XB9K	GO:0005615	5/527	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG85XB9K	GO:0045165	4/527	cell fate commitment	biological_process	"The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
EOG85XB9K	GO:0030182	3/527	neuron differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
EOG85XB9K	GO:0007367	2/527	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG85XB9K	GO:0005576	2/527	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG85XB9K	GO:0048675	2/527	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG85XB9K	GO:0044719	2/527	regulation of imaginal disc-derived wing size	biological_process	"Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
EOG85XB9K	GO:0005515	2/527	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG85XB9K	GO:0008544	1/527	epidermis development	biological_process	"The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]
EOG85XB9K	GO:0048728	1/527	proboscis development	biological_process	"The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure." [GOC:rc]
EOG85XB9K	GO:0060914	1/527	heart formation	biological_process	"The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart]
EOG85XB9K	GO:0001745	1/527	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG85XB9K	GO:0050919	1/527	negative chemotaxis	biological_process	"The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete]
EOG85XB9K	GO:0035147	1/527	branch fusion, open tracheal system	biological_process	"Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584]
EOG85XB9K	GO:0007411	1/527	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG85XB9K	GO:0061332	1/527	Malpighian tubule bud morphogenesis	biological_process	"The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG85XB9K	GO:0002168	1/527	instar larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG85XB9K	GO:0035290	1/527	trunk segmentation	biological_process	"Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402]
EOG85XB9K	GO:0048190	1/527	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG85XB9K	GO:0006355	1/527	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85XB9K	GO:0005112	1/527	Notch binding	molecular_function	"Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb]
EOG85XB9K	GO:0005539	1/527	glycosaminoglycan binding	molecular_function	"Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732]
EOG85XB9K	GO:0035225	1/527	determination of genital disc primordium	biological_process	"Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318]
EOG85XB9K	GO:0061328	1/527	posterior Malpighian tubule development	biological_process	"The process whose specific outcome is the progression of the posterior Malpighian tubule over time, from its formation to the mature structure. The pair of posterior tubules arise from a ventrolateral region of the embryonic hindgut and project backwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10]
EOG85XB9K	GO:0007398	1/527	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG85XB9K	GO:0007419	1/527	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG85XB9K	GO:0030054	1/527	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG85XB9K	GO:0005783	1/527	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG85XB9K	GO:0072091	1/527	regulation of stem cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
EOG85XB9K	GO:0048076	1/527	regulation of compound eye pigmentation	biological_process	"Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid]
EOG85XB9K	GO:0007476	1/527	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG85XB9K	GO:0007507	1/527	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG85XB9K	GO:0048754	1/527	branching morphogenesis of an epithelial tube	biological_process	"The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid]
EOG85XB9K	GO:0046672	1/527	positive regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG85XB9K	GO:0007424	1/527	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG85XB9K	GO:0035277	1/527	spiracle morphogenesis, open tracheal system	biological_process	"The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268]
EOG85XB9K	GO:0005102	1/527	receptor binding	molecular_function	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]
EOG85XB9K	GO:0060061	1/527	Spemann organizer formation	biological_process	"Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:bf, GOC:dph]
EOG85XB9K	GO:0007523	1/527	larval visceral muscle development	biological_process	"The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid]
EOG85XB9K	GO:0035167	1/527	larval lymph gland hemopoiesis	biological_process	"The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385]
EOG85XB9K	GO:0035289	1/527	posterior head segmentation	biological_process	"Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136]
EOG85XB9K	GO:0005771	1/527	multivesicular body	cellular_component	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]
EOG85XB9K	GO:0035017	1/527	cuticle pattern formation	biological_process	"The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf]
EOG85XB9K	GO:0005886	1/527	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG85XB9K	GO:0051017	1/527	actin filament bundle assembly	biological_process	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
EOG85XB9K	GO:0050840	1/527	extracellular matrix binding	molecular_function	"Interacting selectively and non-covalently with a component of the extracellular matrix." [GOC:ai]
EOG85XB9K	GO:0007394	1/527	dorsal closure, elongation of leading edge cells	biological_process	"The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138]
EOG85XB9K	GO:0007444	1/527	imaginal disc development	biological_process	"The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238]
EOG85XB9K	GO:0060070	1/527	canonical Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488]
EOG85XB9K	GO:0014019	1/527	neuroblast development	biological_process	"The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585]
EOG85XB9K	GO:0016015	1/527	morphogen activity	molecular_function	"Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient." [GOC:go_curators]
EOG85XB9K	GO:0007446	1/527	imaginal disc growth	biological_process	"The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387]
EOG85XB9K	GO:0003136	1/527	negative regulation of heart induction by canonical Wnt signaling pathway	biological_process	"Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329]
EOG85XB9K	GO:0035224	1/527	genital disc anterior/posterior pattern formation	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318]
EOG85XB9K	GO:0035217	1/527	labial disc development	biological_process	"Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238]
EOG85XB9K	GO:0030139	1/527	endocytic vesicle	cellular_component	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]
EOG85XB9K	GO:0009996	1/527	negative regulation of cell fate specification	biological_process	"Any process that restricts, stops or prevents a cell from adopting a specific cell fate." [GOC:go_curators]
EOG85XB9K	GO:0016204	1/527	determination of muscle attachment site	biological_process	"The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete]
EOG85XB9K	GO:0007448	1/527	anterior/posterior pattern specification, imaginal disc	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238]
EOG85XB9K	GO:0032876	1/527	negative regulation of DNA endoreduplication	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication." [GOC:mah]
EOG85XB9K	GO:0007391	1/527	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG85XB9K	GO:0007435	1/527	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG85XB9K	GO:0046847	1/527	filopodium assembly	biological_process	"The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790]
EOG85XB9K	GO:0008595	1/527	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG85XB9K	GO:0010002	1/527	cardioblast differentiation	biological_process	"The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG85XB9K	GO:0043066	1/527	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG85XB9K	GO:0035311	1/527	wing cell fate specification	biological_process	"The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment." [PMID:10860999]
EOG85XB9K	GO:0016318	1/527	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG85XB9K	GO:0045202	1/527	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG85XB9K	GO:0007418	1/527	ventral midline development	biological_process	"The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342]
EOG85XB9K	GO:0045892	1/527	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85XB9K	GO:0048542	1/527	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG85XB9K	GO:0007442	1/527	hindgut morphogenesis	biological_process	"The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
EOG85XB9K	GO:0007616	1/527	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG85XB9K	GO:0061382	1/527	Malpighian tubule tip cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells." [GOC:dph, GOC:mtg_kidney_jan10, PMID:7821213]
EOG85XB9K	GO:0042127	1/527	regulation of cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
EOG85XB9K	GO:0035215	1/527	genital disc development	biological_process	"Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318]
EOG85XB9K	GO:0007479	1/527	leg disc proximal/distal pattern formation	biological_process	"The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf]
EOG85XB9K	GO:0016023	1/527	cytoplasmic membrane-bounded vesicle	cellular_component	"A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
EOG85XB9K	GO:0005110	1/527	frizzled-2 binding	molecular_function	"Interacting selectively and non-covalently with frizzled-2 (fz2)." [GOC:ceb, PR:000007719]
EOG85XB9K	GO:0035220	1/527	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG85XB9K	GO:0030707	1/527	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG85XB9K	GO:0009986	1/527	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG85XB9K	GO:0008284	1/527	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG85XB9K	GO:0007423	1/527	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG85XB9K	GO:0007346	1/527	regulation of mitotic cell cycle	biological_process	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG85XB9K	GO:0007447	1/527	imaginal disc pattern formation	biological_process	"The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid]
EOG85XB9K	GO:0042691	1/527	positive regulation of crystal cell differentiation	biological_process	"Any process that activates or increases the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]
EOG85XB9K	GO:0007223	1/527	Wnt signaling pathway, calcium modulating pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:bf, GOC:dph, GOC:go_curators, PMID:11532397]
EOG85XB9K	GO:0035170	1/527	lymph gland crystal cell differentiation	biological_process	"The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
EOG85XB9K	GO:0048749	1/527	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG85XB9K	GO:0035153	1/527	epithelial cell type specification, open tracheal system	biological_process	"Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940]
EOG85XB9K	GO:0007517	1/527	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG85XB9K	GO:0007450	1/527	dorsal/ventral pattern formation, imaginal disc	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238]
EOG85XB9K	GO:0061331	1/527	epithelial cell proliferation involved in Malpighian tubule morphogenesis	biological_process	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG85XB9K	GO:0035263	1/527	genital disc sexually dimorphic development	biological_process	"The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781]
EOG85XB9K	GO:0030032	1/527	lamellipodium assembly	biological_process	"Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194]
EOG85XB9K	GO:0035288	1/527	anterior head segmentation	biological_process	"Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136]
EOG85XB9K	GO:0007498	1/527	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG85XB9K	GO:0061320	1/527	pericardial nephrocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]
EOG85XB9K	GO:0045121	1/527	membrane raft	cellular_component	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198]
EOG85XB9K	GO:0045611	1/527	negative regulation of hemocyte differentiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG85XB9K	GO:0048332	1/527	mesoderm morphogenesis	biological_process	"The process in which the anatomical structures of the mesoderm are generated and organized." [GOC:go_curators]
EOG8SBHC4	GO:0016757	24/96	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8SBHC4	GO:0005789	1/96	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8SBHC4	GO:0016021	1/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SBHC4	GO:0097502	1/96	mannosylation	biological_process	"The covalent attachment of a mannose residue to a substrate molecule." [GOC:cjm]
EOG8SBHC4	GO:0006506	1/96	GPI anchor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
EOG8SBHC4	GO:0000026	1/96	alpha-1,2-mannosyltransferase activity	molecular_function	"Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage." [GOC:mcc, PMID:10521541]
EOG8SBHC4	GO:0005783	1/96	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG87H84S	GO:0003677	2/10	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG87H84S	GO:0006355	2/10	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG87H84S	GO:0003676	1/10	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG87H84S	GO:0008270	1/10	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG85XB9B	GO:0004114	11/77	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular_function	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]
EOG85XB9B	GO:0007165	11/77	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG85XB9B	GO:0046872	7/77	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8G4K5P	GO:0032926	1/81	negative regulation of activin receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl]
EOG8G4K5P	GO:0032927	1/81	positive regulation of activin receptor signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl]
EOG8G4K5P	GO:0090099	1/81	negative regulation of decapentaplegic signaling pathway	biological_process	"Any process that decreases the frequency, rate, or extent of the decapentaplegic signaling pathway. The decapentaplegic signaling pathway is the series of molecular signals generated as a consequence of the signal decapentaplegic binding to one of its physiological receptors." [GOC:dph, GOC:tb]
EOG8G4K5P	GO:0005576	1/81	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8284FM	GO:0000145	22/89	exocyst	cellular_component	"A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152]
EOG8284FM	GO:0006904	22/89	vesicle docking involved in exocytosis	biological_process	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]
EOG8284FM	GO:0015031	22/89	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8SBHC9	GO:0016740	1/42	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8284FW	GO:0003676	21/84	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8284FW	GO:0046872	20/84	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8284FW	GO:0008270	1/84	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8284FW	GO:0005634	1/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85XB9X	GO:0016021	3/86	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85XB9X	GO:0005886	1/86	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG85XB9X	GO:0005230	1/86	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG85XB9X	GO:2001283	1/86	Roundabout signaling pathway involved in muscle cell chemotaxis toward tendon cell	biological_process	"Any Roundabout signaling pathway that is involved in the directed movement of a muscle cell towards a tendon cell in response to an external stimulus." [GOC:bf, GOC:obol, GOC:sart, PMID:19793885]
EOG85XB9X	GO:0005515	1/86	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG85XB9X	GO:2001282	1/86	negative regulation of muscle cell chemotaxis toward tendon cell	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a muscle cell towards a tendon cell in response to an external stimulus. For example, when the muscle cell arrives at the target tendon cell, migration is arrested so that attachments can be made between the cells." [GOC:sart, PMID:19793885, PMID:20404543]
EOG85XB9X	GO:0016020	1/86	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG85XB9X	GO:0005927	1/86	muscle tendon junction	cellular_component	"A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007]
EOG85XB9X	GO:0043234	1/86	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8284FS	GO:0005524	15/48	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8284FS	GO:0003676	14/48	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8284FS	GO:0008026	11/48	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8284FS	GO:0004386	4/48	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8284FS	GO:0006351	1/48	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8284FS	GO:0003677	1/48	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8284FS	GO:0003899	1/48	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8284FQ	GO:0008352	24/98	katanin complex	cellular_component	"A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766]
EOG8284FQ	GO:0051013	24/98	microtubule severing	biological_process	"The process in which a microtubule is broken down into smaller segments." [GOC:ai, PMID:14657234]
EOG8284FQ	GO:0005874	18/98	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8284FQ	GO:0005813	18/98	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8284FQ	GO:0007067	18/98	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8284FQ	GO:0000922	18/98	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8284FQ	GO:0046843	1/98	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8284FQ	GO:0008017	1/98	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8284FQ	GO:0016740	1/98	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8284FQ	GO:0007017	1/98	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8G4K5C	GO:0000166	10/47	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8G4K5C	GO:0003676	1/47	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8284FX	GO:0003676	23/90	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8284FX	GO:0071011	1/90	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8284FX	GO:0000398	1/90	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8R7XRZ	GO:0051928	1/137	positive regulation of calcium ion transport	biological_process	"Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8R7XRZ	GO:0005886	1/137	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8R7XRZ	GO:0005887	1/137	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8R7XRZ	GO:0004252	1/137	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8R7XRZ	GO:0007399	1/137	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8R7XRZ	GO:0015279	1/137	store-operated calcium channel activity	molecular_function	"A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710]
EOG8R7XRZ	GO:0051533	1/137	positive regulation of NFAT protein import into nucleus	biological_process	"Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai]
EOG8R7XRZ	GO:0002115	1/137	store-operated calcium entry	biological_process	"A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991]
EOG8JT2MB	GO:0003723	1/11	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8JT2MB	GO:0006520	1/11	cellular amino acid metabolic process	biological_process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]
EOG8JT2MB	GO:0004252	1/11	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8JT2MB	GO:0005215	1/11	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8JT2MB	GO:0006207	1/11	'de novo' pyrimidine nucleobase biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]
EOG8JT2MB	GO:0055085	1/11	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8JT2MB	GO:0001522	1/11	pseudouridine synthesis	biological_process	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]
EOG8JT2MB	GO:0004070	1/11	aspartate carbamoyltransferase activity	molecular_function	"Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate." [EC:2.1.3.2, RHEA:20016]
EOG8JT2MB	GO:0004190	1/11	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8JT2MB	GO:0016597	1/11	amino acid binding	molecular_function	"Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]
EOG8JT2MB	GO:0016020	1/11	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8JT2MB	GO:0009982	1/11	pseudouridine synthase activity	molecular_function	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]
EOG8R7XRN	GO:0016021	104/311	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8R7XRN	GO:0015171	103/311	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8R7XRN	GO:0003333	3/311	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG8R7XRN	GO:0006865	1/311	amino acid transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8R7XRN	GO:0006629	1/311	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8R7XRN	GO:0015326	1/311	basic amino acid transmembrane transporter activity	molecular_function	"Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8R7XRN	GO:0000398	1/311	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8R7XRN	GO:0050829	1/311	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8R7XRN	GO:0045824	1/311	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG8R7XRN	GO:0071011	1/311	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8R7XRN	GO:0040007	1/311	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG8R7XRN	GO:0006812	1/311	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG87H84Z	GO:0009401	3/12	phosphoenolpyruvate-dependent sugar phosphotransferase system	biological_process	"The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html]
EOG87H84Z	GO:0008982	3/12	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	molecular_function	"Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-]
EOG87H84Z	GO:0005351	3/12	sugar:proton symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]
EOG87H84Z	GO:0016020	2/12	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG87H84Z	GO:0016021	1/12	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87H84Z	GO:0016620	1/12	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG87H84Z	GO:0005524	1/12	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87H84Z	GO:0016887	1/12	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG87H84Z	GO:0016861	1/12	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [GOC:jl]
EOG87H84Z	GO:0016491	1/12	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8CRPGB	GO:0004792	13/104	thiosulfate sulfurtransferase activity	molecular_function	"Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate." [EC:2.8.1.1, RHEA:16884]
EOG8CRPGB	GO:0006950	2/104	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG87SVTS	GO:0005524	25/88	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87SVTS	GO:0008026	23/88	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG87SVTS	GO:0003723	22/88	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG87SVTS	GO:0003676	3/88	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG87SVTS	GO:0004386	1/88	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG87SVTS	GO:0006200	1/88	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG87SVTS	GO:0004004	1/88	ATP-dependent RNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]
EOG87SVTP	GO:0006915	29/109	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG87SVTP	GO:0045786	29/109	negative regulation of cell cycle	biological_process	"Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG87SVTP	GO:0005912	1/109	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG87SVTP	GO:0030296	1/109	protein tyrosine kinase activator activity	molecular_function	"Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732]
EOG87SVTP	GO:0061098	1/109	positive regulation of protein tyrosine kinase activity	biological_process	"Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb]
EOG87SVTP	GO:0004623	1/109	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG8X6FQF	GO:0017183	25/87	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	biological_process	"The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380, RESID:AA0040]
EOG8X6FQF	GO:0004164	25/87	diphthine synthase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine." [EC:2.1.1.98]
EOG8X6FQM	GO:0051920	68/238	peroxiredoxin activity	molecular_function	"Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." [EC:1.11.1.15]
EOG8X6FQM	GO:0016209	57/238	antioxidant activity	molecular_function	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
EOG8X6FQM	GO:0004601	11/238	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG8X6FQM	GO:0042744	3/238	hydrogen peroxide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]
EOG8X6FQM	GO:0008379	3/238	thioredoxin peroxidase activity	molecular_function	"Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O." [MetaCyc:RXN0-267]
EOG8X6FQM	GO:0045454	2/238	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8X6FQM	GO:0006974	2/238	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8X6FQM	GO:0005829	2/238	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8X6FQM	GO:0005515	2/238	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8X6FQM	GO:0008340	2/238	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8X6FQM	GO:0008354	1/238	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8X6FQM	GO:0005576	1/238	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8X6FQM	GO:0007281	1/238	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8X6FQM	GO:0007155	1/238	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8X6FQM	GO:0043066	1/238	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8X6FQM	GO:0005875	1/238	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8X6FQM	GO:0042594	1/238	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8X6FQM	GO:0005783	1/238	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8X6FQM	GO:0006979	1/238	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8X6FQM	GO:0006909	1/238	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8X6FQM	GO:0005739	1/238	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8X6FQM	GO:0097190	1/238	apoptotic signaling pathway	biological_process	"A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]
EOG82Z75S	GO:0005615	1/81	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8X6FQW	GO:0007476	1/95	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8SXQV9	GO:0007264	46/178	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8SXQV9	GO:0005525	46/178	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8SXQV9	GO:0006184	45/178	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8SXQV9	GO:0016020	43/178	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8SXQV9	GO:0005886	13/178	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8SXQV9	GO:0004767	2/178	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8SXQV9	GO:0005515	2/178	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8SXQV9	GO:0030707	1/178	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8SXQV9	GO:0016049	1/178	cell growth	biological_process	"The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]
EOG8SXQV9	GO:0035088	1/178	establishment or maintenance of apical/basal cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483]
EOG8SXQV9	GO:0008284	1/178	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG8SXQV9	GO:0060438	1/178	trachea development	biological_process	"The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG8SXQV9	GO:0007476	1/178	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8SXQV9	GO:0009267	1/178	cellular response to starvation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]
EOG8SXQV9	GO:0007507	1/178	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8SXQV9	GO:0040008	1/178	regulation of growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]
EOG8SXQV9	GO:0008586	1/178	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG8SXQV9	GO:0046534	1/178	positive regulation of photoreceptor cell differentiation	biological_process	"Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
EOG8SXQV9	GO:0008293	1/178	torso signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
EOG8SXQV9	GO:0008361	1/178	regulation of cell size	biological_process	"Any process that modulates the size of a cell." [GOC:go_curators]
EOG8SXQV9	GO:0048865	1/178	stem cell fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete]
EOG8SXQV9	GO:0007422	1/178	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8SXQV9	GO:0043410	1/178	positive regulation of MAPK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]
EOG8SXQV9	GO:0048749	1/178	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8SXQV9	GO:0030381	1/178	chorion-containing eggshell pattern formation	biological_process	"The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu]
EOG8SXQV9	GO:0042981	1/178	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8SXQV9	GO:0001709	1/178	cell fate determination	biological_process	"A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
EOG8SXQV9	GO:0010507	1/178	negative regulation of autophagy	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8SXQV9	GO:0030307	1/178	positive regulation of cell growth	biological_process	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8SXQV9	GO:0007369	1/178	gastrulation	biological_process	"A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]
EOG8SXQV9	GO:0016242	1/178	negative regulation of macroautophagy	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]
EOG8SXQV9	GO:0038202	1/178	TORC1 signaling	biological_process	"A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]
EOG8SXQV9	GO:0001558	1/178	regulation of cell growth	biological_process	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8SXQV9	GO:2001234	1/178	negative regulation of apoptotic signaling pathway	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]
EOG8SXQV9	GO:0008594	1/178	photoreceptor cell morphogenesis	biological_process	"The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
EOG8SXQV9	GO:0048863	1/178	stem cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]
EOG8SXQV9	GO:0007455	1/178	eye-antennal disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8SXQV9	GO:0036335	1/178	intestinal stem cell homeostasis	biological_process	"Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells." [GOC:nhn, PMID:22042863]
EOG8SXQV9	GO:0045793	1/178	positive regulation of cell size	biological_process	"Any process that increases cell size." [GOC:go_curators]
EOG8SXQV9	GO:0035099	1/178	hemocyte migration	biological_process	"The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551]
EOG8SXQV9	GO:0007309	1/178	oocyte axis specification	biological_process	"The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8SXQV9	GO:0008595	1/178	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8SXQV9	GO:0007298	1/178	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8SXQV9	GO:0006606	1/178	protein import into nucleus	biological_process	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]
EOG8SXQV9	GO:0072089	1/178	stem cell proliferation	biological_process	"The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
EOG8SXQV9	GO:0072002	1/178	Malpighian tubule development	biological_process	"The process whose specific outcome is the progression of the Malpighian tubule over time, from its formation to the mature structure. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [FBbt:00005786, GOC:mtg_kidney_jan10, PMID:19783135]
EOG8SXQV9	GO:0008283	1/178	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8SXQV9	GO:0002168	1/178	instar larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8SXQV9	GO:0007391	1/178	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8SXQV9	GO:0007472	1/178	wing disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8SXQV9	GO:0007552	1/178	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG8SXQV9	GO:0007428	1/178	primary branching, open tracheal system	biological_process	"Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG8SXQV9	GO:0000082	1/178	G1/S transition of mitotic cell cycle	biological_process	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]
EOG8SXQV9	GO:0040014	1/178	regulation of multicellular organism growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG8SXQV9	GO:0045610	1/178	regulation of hemocyte differentiation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG8SXQV9	GO:0043066	1/178	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8SXQV9	GO:0001708	1/178	cell fate specification	biological_process	"The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators]
EOG8SXQV9	GO:0046673	1/178	negative regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG8SXQV9	GO:0045500	1/178	sevenless signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:10771085]
EOG8SXQV9	GO:0007426	1/178	tracheal outgrowth, open tracheal system	biological_process	"The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8SXQV9	GO:0003924	1/178	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8CRPGZ	GO:0003677	4/233	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CRPGZ	GO:0006351	1/233	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8CRPGZ	GO:0003899	1/233	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8CRPGZ	GO:0003676	1/233	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SXQV3	GO:0016787	4/102	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8SXQV3	GO:0008477	2/102	purine nucleosidase activity	molecular_function	"Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose." [EC:3.2.2.1]
EOG8M9457	GO:0007268	26/130	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8M9457	GO:0019992	26/130	diacylglycerol binding	molecular_function	"Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids." [GOC:ma]
EOG8M9457	GO:0046872	20/130	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8M9457	GO:0035556	20/130	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8M9457	GO:0008021	1/130	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8M9457	GO:0007269	1/130	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8M9457	GO:0016079	1/130	synaptic vesicle exocytosis	biological_process	"Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
EOG8M9457	GO:0045211	1/130	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8M9457	GO:0016082	1/130	synaptic vesicle priming	biological_process	"The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342]
EOG8M9457	GO:0005516	1/130	calmodulin binding	molecular_function	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
EOG8M9457	GO:0043195	1/130	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG82Z75C	GO:0003700	35/139	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG82Z75C	GO:0005634	35/139	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82Z75C	GO:0043565	30/139	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG82Z75C	GO:0000976	5/139	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG82Z75C	GO:0004000	2/139	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG82Z75C	GO:0007389	1/139	pattern specification process	biological_process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
EOG82Z75C	GO:0007485	1/139	imaginal disc-derived male genitalia development	biological_process	"The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
EOG82Z75C	GO:0007398	1/139	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG82Z75C	GO:0007450	1/139	dorsal/ventral pattern formation, imaginal disc	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238]
EOG82Z75C	GO:0007517	1/139	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG82Z75C	GO:0035309	1/139	wing and notum subfield formation	biological_process	"The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999]
EOG82Z75C	GO:0009953	1/139	dorsal/ventral pattern formation	biological_process	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG82Z75C	GO:0010629	1/139	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG82Z75C	GO:0042659	1/139	regulation of cell fate specification	biological_process	"Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators]
EOG82Z75C	GO:0006355	1/139	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82Z75C	GO:0007420	1/139	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG82Z75C	GO:0007419	1/139	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG82Z75C	GO:0021782	1/139	glial cell development	biological_process	"The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG82Z75C	GO:0007476	1/139	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG82Z75C	GO:0035222	1/139	wing disc pattern formation	biological_process	"The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf]
EOG82Z75C	GO:0007400	1/139	neuroblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
EOG82Z75C	GO:0007417	1/139	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8GF5W3	GO:0008270	25/108	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GF5W3	GO:0005634	24/108	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GF5W3	GO:0003700	23/108	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8GF5W3	GO:0043565	23/108	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8GF5W3	GO:0016740	2/108	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8GF5W3	GO:0007391	1/108	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8GF5W3	GO:0007411	1/108	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8GF5W3	GO:0043433	1/108	negative regulation of sequence-specific DNA binding transcription factor activity	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl]
EOG8GF5W3	GO:0008045	1/108	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8GF5W3	GO:0008293	1/108	torso signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
EOG8GF5W3	GO:0070983	1/108	dendrite guidance	biological_process	"The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
EOG8GF5W3	GO:0007507	1/108	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8GF5W3	GO:0007521	1/108	muscle cell fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators]
EOG8GF5W3	GO:0008407	1/108	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG8GF5W3	GO:0046665	1/108	amnioserosa maintenance	biological_process	"Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis." [GOC:bf]
EOG8GF5W3	GO:0045944	1/108	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8GF5W3	GO:0001102	1/108	RNA polymerase II activating transcription factor binding	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription." [GOC:txnOH]
EOG8GF5W3	GO:0048542	1/108	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG8GF5W3	GO:0022416	1/108	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8GF5W3	GO:0008258	1/108	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8GF5W3	GO:0010468	1/108	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8GF5W3	GO:0035310	1/108	notum cell fate specification	biological_process	"The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment." [PMID:10860999]
EOG8GF5W3	GO:0005515	1/108	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8GF5W3	GO:0000980	1/108	RNA polymerase II distal enhancer sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH]
EOG8GF5W3	GO:0007390	1/108	germ-band shortening	biological_process	"The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138]
EOG8GF5W3	GO:0006366	1/108	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8GF5W3	GO:0003705	1/108	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG8GF5W3	GO:0007362	1/108	terminal region determination	biological_process	"Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8GF5W3	GO:0000977	1/108	RNA polymerase II regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
EOG8GB9M3	GO:0035556	14/47	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8GB9M3	GO:0005089	14/47	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8GB9M3	GO:0003676	1/47	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GB9M3	GO:0015074	1/47	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8NW20X	GO:0035556	22/96	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8NW20X	GO:0016021	22/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NW20X	GO:0000166	22/96	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8NW20X	GO:0016849	13/96	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG8NW20X	GO:0009190	13/96	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG8NW20X	GO:0004383	9/96	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG8NW20X	GO:0006182	1/96	cGMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]
EOG8GB9M5	GO:0016020	10/134	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8GB9M5	GO:0004896	10/134	cytokine receptor activity	molecular_function	"Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah]
EOG8GB9M5	GO:0046982	2/134	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8GB9M5	GO:0003723	1/134	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8GB9M5	GO:0035335	1/134	peptidyl-tyrosine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
EOG8GB9M5	GO:0007259	1/134	JAK-STAT cascade	biological_process	"Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028]
EOG8GB9M5	GO:0006955	1/134	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8GB9M5	GO:0050829	1/134	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GB9M5	GO:0042532	1/134	negative regulation of tyrosine phosphorylation of STAT protein	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]
EOG8GB9M5	GO:0004888	1/134	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8GB9M5	GO:0045475	1/134	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8GB9M5	GO:0007616	1/134	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8GB9M5	GO:0046426	1/134	negative regulation of JAK-STAT cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG8GB9M5	GO:0016327	1/134	apicolateral plasma membrane	cellular_component	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
EOG8GB9M5	GO:0007442	1/134	hindgut morphogenesis	biological_process	"The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
EOG8GB9M5	GO:0007350	1/134	blastoderm segmentation	biological_process	"The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8GB9M5	GO:0016021	1/134	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GB9M5	GO:0042742	1/134	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8GB9M5	GO:0008284	1/134	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG8GB9M5	GO:0045824	1/134	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG8GB9M5	GO:0001745	1/134	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8GB9M5	GO:0007424	1/134	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8GB9M5	GO:0006470	1/134	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8GB9M5	GO:0016162	1/134	cellulose 1,4-beta-cellobiosidase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91]
EOG8GB9M5	GO:0016324	1/134	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8GB9M5	GO:0007298	1/134	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8GB9M5	GO:0003964	1/134	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8GB9M5	GO:0004872	1/134	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8GB9M5	GO:0004725	1/134	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8GB9M5	GO:0007425	1/134	epithelial cell fate determination, open tracheal system	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940]
EOG8XSP61	GO:0003676	3/275	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XSP61	GO:0003677	2/275	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XSP61	GO:0015074	2/275	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8XSP61	GO:0003887	1/275	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8XSP61	GO:0000166	1/275	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG870WX7	GO:0005634	28/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG870WX7	GO:0003677	28/103	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG870WX7	GO:0006355	3/103	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG870WX7	GO:0008587	3/103	imaginal disc-derived wing margin morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG870WX7	GO:0007379	3/103	segment specification	biological_process	"The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG870WX7	GO:0016055	3/103	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG870WX7	GO:0046530	3/103	photoreceptor cell differentiation	biological_process	"The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732]
EOG870WX7	GO:0016568	3/103	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG870WX7	GO:0006351	3/103	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG870WX7	GO:0042058	1/103	regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG870WX7	GO:0005515	1/103	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG870WX7	GO:0014017	1/103	neuroblast fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585]
EOG870WX7	GO:0022008	1/103	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG870WX7	GO:0007476	1/103	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG870WX7	GO:0007480	1/103	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG870WX7	GO:0008586	1/103	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG870WX7	GO:0035060	1/103	brahma complex	cellular_component	"A SWI/SNF-type complex that contains the ATPase product of the Drosophila brahma gene, or an ortholog thereof." [GOC:bf, PMID:10809665, PMID:12482982]
EOG870WX7	GO:0048190	1/103	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG870WX7	GO:0045893	1/103	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8ZCWMQ	GO:0000723	130/891	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8ZCWMQ	GO:0006281	130/891	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8ZCWMQ	GO:0003678	130/891	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8ZCWMQ	GO:0005524	46/891	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZCWMQ	GO:0004386	20/891	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8ZCWMQ	GO:0003676	5/891	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZCWMQ	GO:0005634	2/891	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZCWMQ	GO:0003677	2/891	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8ZCWMQ	GO:0008234	1/891	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8ZCWMQ	GO:0006508	1/891	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8ZCWMQ	GO:0008270	1/891	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZCWMQ	GO:0046872	1/891	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z655Q	GO:0003676	1/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SR0B8	GO:0016772	3/36	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8GB9MZ	GO:0050660	281/974	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8GB9MZ	GO:0008812	249/974	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG8GB9MZ	GO:0006066	249/974	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG8GB9MZ	GO:0016614	32/974	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8GB9MZ	GO:0004198	12/974	calcium-dependent cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]
EOG8GB9MZ	GO:0005622	12/974	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8GB9MZ	GO:0004344	11/974	glucose dehydrogenase activity	molecular_function	"Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10]
EOG8GB9MZ	GO:0005509	10/974	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8GB9MZ	GO:0016491	9/974	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8GB9MZ	GO:0045455	9/974	ecdysteroid metabolic process	biological_process	"The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732]
EOG8GB9MZ	GO:0008270	1/974	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GB9MZ	GO:0006915	1/974	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8GB9MZ	GO:0042600	1/974	chorion	cellular_component	"A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
EOG8GB9MZ	GO:0004190	1/974	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8GB9MZ	GO:0003676	1/974	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GB9MZ	GO:0004197	1/974	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8GB9MZ	GO:0046331	1/974	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8GB9MZ	GO:0015074	1/974	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG82FW26	GO:0004930	9/10	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG82FW26	GO:0016021	9/10	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82FW26	GO:0009881	8/10	photoreceptor activity	molecular_function	"The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators]
EOG82FW26	GO:0007601	8/10	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG82FW26	GO:0007602	8/10	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG82FW26	GO:0018298	8/10	protein-chromophore linkage	biological_process	"The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma]
EOG8GB9MK	GO:0006355	25/90	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8GB9MK	GO:0097372	25/90	NAD-dependent histone deacetylase activity (H3-K18 specific)	molecular_function	"Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein." [EC:3.5.1.17, GOC:sp, PMID:22722849, RHEA:24551]
EOG8GB9MK	GO:0032041	25/90	NAD-dependent histone deacetylase activity (H3-K14 specific)	molecular_function	"Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [EC:3.5.1.17, RHEA:24551]
EOG8GB9MK	GO:0006351	25/90	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8GB9MK	GO:0005634	25/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GB9MK	GO:0046969	25/90	NAD-dependent histone deacetylase activity (H3-K9 specific)	molecular_function	"Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [EC:3.5.1.17, RHEA:24551]
EOG8GB9MK	GO:0046970	25/90	NAD-dependent histone deacetylase activity (H4-K16 specific)	molecular_function	"Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [EC:3.5.1.17, GOC:vw, RHEA:24551]
EOG8GB9MK	GO:0043066	1/90	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8GB9MK	GO:0016049	1/90	cell growth	biological_process	"The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]
EOG8GB9MK	GO:0043984	1/90	histone H4-K16 acetylation	biological_process	"The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone." [GOC:jl]
EOG8GB9MK	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8GB9MK	GO:0006342	1/90	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG8GB9MK	GO:0004407	1/90	histone deacetylase activity	molecular_function	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.98, PMID:9893272]
EOG8GB9MK	GO:0005737	1/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8VDSD5	GO:0016747	5/16	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8C2KSQ	GO:0003723	3/9	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8C2KSQ	GO:0003964	3/9	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8GB9MD	GO:0006177	2/10	GMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732]
EOG8GB9MD	GO:0005524	2/10	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8GB9MD	GO:0003922	2/10	GMP synthase (glutamine-hydrolyzing) activity	molecular_function	"Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate." [EC:6.3.5.2]
EOG8GB9MD	GO:0016462	2/10	pyrophosphatase activity	molecular_function	"Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, GOC:curators]
EOG8M945C	GO:0044267	23/106	cellular protein metabolic process	biological_process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]
EOG8M945C	GO:0005524	23/106	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8M945C	GO:0016307	20/106	phosphatidylinositol phosphate kinase activity	molecular_function	"Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495]
EOG8M945C	GO:0046872	19/106	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8M945C	GO:0035556	18/106	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8M945C	GO:0000285	3/106	1-phosphatidylinositol-3-phosphate 5-kinase activity	molecular_function	"Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13612]
EOG8M945C	GO:0005768	1/106	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG8M945C	GO:0000046	1/106	autophagosome maturation	biological_process	"The process in which autophagosomes, double-membraned vacuoles containing cytoplasmic material fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [GOC:autophagy, GOC:lf, PMID:11099404, PMID:16874026, PMID:17534139]
EOG8M945C	GO:0016308	1/106	1-phosphatidylinositol-4-phosphate 5-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.68, RHEA:14428]
EOG8M945C	GO:0010008	1/106	endosome membrane	cellular_component	"The lipid bilayer surrounding an endosome." [GOC:mah]
EOG8M945C	GO:0008333	1/106	endosome to lysosome transport	biological_process	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]
EOG8M945C	GO:0046854	1/106	phosphatidylinositol phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]
EOG8M945C	GO:0016310	1/106	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG8M945C	GO:0008270	1/106	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8M945C	GO:0012506	1/106	vesicle membrane	cellular_component	"The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah]
EOG8SXQVF	GO:0010181	21/88	FMN binding	molecular_function	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]
EOG8SXQVF	GO:0016491	21/88	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8SXQVF	GO:0004842	1/88	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8SXQVF	GO:0008134	1/88	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8SXQVF	GO:0006749	1/88	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG8SXQVF	GO:0071797	1/88	LUBAC complex	cellular_component	"A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex." [GOC:sp, PMID:17006537, PMID:19136968, PMID:21455180]
EOG8SXQVF	GO:0003840	1/88	gamma-glutamyltransferase activity	molecular_function	"Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2]
EOG8M945D	GO:0034597	1/107	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [GOC:mah]
EOG8M945D	GO:0016316	1/107	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [EC:3.1.3.66, GOC:hb]
EOG8M945Z	GO:0006810	24/99	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8M945Z	GO:0007067	24/99	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8M945Z	GO:0005874	23/99	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8M945Z	GO:0005737	23/99	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8M945Z	GO:0000132	22/99	establishment of mitotic spindle orientation	biological_process	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
EOG8M945Z	GO:0005875	21/99	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8M945Z	GO:0006928	21/99	movement of cell or subcellular component	biological_process	"The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg]
EOG8M945Z	GO:0005815	21/99	microtubule organizing center	cellular_component	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416]
EOG8M945Z	GO:0016787	3/99	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8M945Z	GO:0030706	1/99	germarium-derived oocyte differentiation	biological_process	"The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8M945Z	GO:0030424	1/99	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8M945Z	GO:0043025	1/99	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8M945Z	GO:0007018	1/99	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8M945Z	GO:0030381	1/99	chorion-containing eggshell pattern formation	biological_process	"The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu]
EOG8M945Z	GO:0030425	1/99	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8M945Z	GO:0030234	1/99	enzyme regulator activity	molecular_function	"Binds to and modulates the activity of an enzyme." [GOC:mah]
EOG8M945Z	GO:0046716	1/99	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG8M945Z	GO:0030473	1/99	nuclear migration along microtubule	biological_process	"The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators]
EOG8M945Z	GO:0030723	1/99	ovarian fusome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]
EOG8M945Z	GO:0005813	1/99	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8M945Z	GO:0030716	1/99	oocyte fate determination	biological_process	"The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
EOG8M945Z	GO:0051383	1/99	kinetochore organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8M945Z	GO:0007312	1/99	oocyte nucleus migration involved in oocyte dorsal/ventral axis specification	biological_process	"The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb]
EOG8M945Z	GO:0016740	1/99	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8M945Z	GO:0007303	1/99	cytoplasmic transport, nurse cell to oocyte	biological_process	"The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238]
EOG8M945Z	GO:0046843	1/99	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8M945Z	GO:0051299	1/99	centrosome separation	biological_process	"The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai]
EOG8M945Z	GO:0048814	1/99	regulation of dendrite morphogenesis	biological_process	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG8M945Z	GO:0051647	1/99	nucleus localization	biological_process	"Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
EOG8M945Z	GO:0007294	1/99	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8M945Z	GO:0006200	1/99	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8M945Z	GO:0042052	1/99	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8M945Z	GO:0007298	1/99	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8M945Z	GO:0000776	1/99	kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG8M945Z	GO:0051225	1/99	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG8M945Z	GO:0010970	1/99	microtubule-based transport	biological_process	"Microtubule-based movement that results in the net, directed movement of organelles or other particles from one location in the cell to another." [GOC:dph, GOC:mah, GOC:tb]
EOG8M945Z	GO:0000777	1/99	condensed chromosome kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG8M945Z	GO:0007093	1/99	mitotic cell cycle checkpoint	biological_process	"A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle]
EOG8M945Z	GO:0034501	1/99	protein localization to kinetochore	biological_process	"Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]
EOG8M945Z	GO:0042623	1/99	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8M945Z	GO:0005938	1/99	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8M945Z	GO:0043143	1/99	regulation of translation by machinery localization	biological_process	"Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl]
EOG8M945Z	GO:0051642	1/99	centrosome localization	biological_process	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
EOG8M945Z	GO:0016319	1/99	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8M945Z	GO:0008088	1/99	axon cargo transport	biological_process	"The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194]
EOG8M945Z	GO:0007405	1/99	neuroblast proliferation	biological_process	"The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart]
EOG8M945Z	GO:0000922	1/99	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8M945Z	GO:0030286	1/99	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8M945Z	GO:0048142	1/99	germarium-derived cystoblast division	biological_process	"The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu, PMID:11131529]
EOG8M945Z	GO:0005828	1/99	kinetochore microtubule	cellular_component	"Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194]
EOG8M945Z	GO:0008104	1/99	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8M945Z	GO:0019827	1/99	stem cell population maintenance	biological_process	"The process by which an organism or tissue maintains a population of stem cells of a single type.  This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437]
EOG8M945Z	GO:0048135	1/99	female germ-line cyst formation	biological_process	"Formation of a group of interconnected cells derived from a single female gonial founder cell." [GOC:jid, PMID:10370240]
EOG8M945Z	GO:0045478	1/99	fusome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells." [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah]
EOG8M945Z	GO:0007283	1/99	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8M945Z	GO:0005869	1/99	dynactin complex	cellular_component	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]
EOG8M945Z	GO:0016358	1/99	dendrite development	biological_process	"The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8M945Z	GO:0072499	1/99	photoreceptor cell axon guidance	biological_process	"The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
EOG8M945Z	GO:0008298	1/99	intracellular mRNA localization	biological_process	"Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai]
EOG8M945Z	GO:0030510	1/99	regulation of BMP signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah]
EOG8M945Z	GO:0007097	1/99	nuclear migration	biological_process	"The directed movement of the nucleus." [GOC:ai]
EOG8M945Z	GO:0048477	1/99	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8M945Z	GO:0045502	1/99	dynein binding	molecular_function	"Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules." [GOC:bf]
EOG8M945Z	GO:0048813	1/99	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8M945Z	GO:0031616	1/99	spindle pole centrosome	cellular_component	"A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah]
EOG8M945Z	GO:2001019	1/99	positive regulation of retrograde axon cargo transport	biological_process	"Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol]
EOG8M945Z	GO:0006886	1/99	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8M945Z	GO:0050790	1/99	regulation of catalytic activity	biological_process	"Any process that modulates the activity of an enzyme." [GOC:ai]
EOG8M945X	GO:0004970	15/52	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8M945X	GO:0005234	15/52	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8M945X	GO:0016021	8/52	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M945X	GO:0016020	8/52	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8M945X	GO:0005215	3/52	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8M945X	GO:0015276	1/52	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8M945X	GO:0050907	1/52	detection of chemical stimulus involved in sensory perception	biological_process	"The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
EOG8M945X	GO:0036081	1/52	extracellular ammonia-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
EOG8M945X	GO:0034220	1/52	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8NS5TG	GO:0035208	1/89	positive regulation of hemocyte proliferation	biological_process	"Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8CRPG8	GO:0008270	18/63	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CRPG8	GO:0003676	1/63	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CRPG8	GO:0003824	1/63	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8CRPG8	GO:0000166	1/63	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8CJZ0M	GO:0007275	7/34	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8CJZ0M	GO:0016021	7/34	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CJZ0M	GO:0007219	7/34	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8X6FQ8	GO:0043565	9/38	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8X6FQ8	GO:0003700	9/38	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8X6FQ8	GO:0005634	8/38	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X6FQ8	GO:0003677	2/38	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X6FQ8	GO:0006909	1/38	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8X6FQ8	GO:2000179	1/38	positive regulation of neural precursor cell proliferation	biological_process	"Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]
EOG8X6FQ8	GO:0001748	1/38	optic lobe placode development	biological_process	"The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833]
EOG8M945T	GO:0016021	82/190	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M945T	GO:0022857	58/190	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8M945T	GO:0055085	24/190	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8M945T	GO:0005215	10/190	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8BGCB1	GO:0009411	1/86	response to UV	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]
EOG8BGCB1	GO:0009314	1/86	response to radiation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation]
EOG8BGCB1	GO:0007280	1/86	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG8BGCB1	GO:0007093	1/86	mitotic cell cycle checkpoint	biological_process	"A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle]
EOG8BGCB1	GO:0005694	1/86	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8BGCB1	GO:0007444	1/86	imaginal disc development	biological_process	"The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238]
EOG8BGCB1	GO:0046982	1/86	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8BGCB1	GO:0000077	1/86	DNA damage checkpoint	biological_process	"A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle]
EOG8BGCB1	GO:0005875	1/86	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8BGCB1	GO:0008103	1/86	oocyte microtubule cytoskeleton polarization	biological_process	"Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042]
EOG8BGCB1	GO:0005515	1/86	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8BGCB1	GO:0005634	1/86	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BGCB1	GO:0008340	1/86	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8BGCB1	GO:0045172	1/86	germline ring canal	cellular_component	"Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801]
EOG8BGCB1	GO:0007411	1/86	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8BGCB1	GO:0045927	1/86	positive regulation of growth	biological_process	"Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
EOG8BGCB1	GO:0007095	1/86	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8BGCB1	GO:0007294	1/86	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8BGCB1	GO:0048190	1/86	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8BGCB1	GO:0005737	1/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8BGCB1	GO:0040008	1/86	regulation of growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]
EOG8BGCB1	GO:0007088	1/86	regulation of mitotic nuclear division	biological_process	"Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
EOG8P5NSV	GO:0003964	1/8	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8P5NSV	GO:0003723	1/8	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8ZSCJC	GO:0003824	31/119	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8ZSCJC	GO:0006777	8/119	Mo-molybdopterin cofactor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473]
EOG8ZSCJC	GO:0003723	1/119	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8ZSCJC	GO:0004604	1/119	phosphoadenylyl-sulfate reductase (thioredoxin) activity	molecular_function	"Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS." [EC:1.8.4.8, RHEA:11727]
EOG8ZSCJC	GO:0003919	1/119	FMN adenylyltransferase activity	molecular_function	"Catalysis of the reaction: ATP + FMN = diphosphate + FAD." [EC:2.7.7.2, RHEA:17240]
EOG8FN6XJ	GO:0005524	25/85	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8FN6XJ	GO:0016021	25/85	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FN6XJ	GO:0035556	24/85	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8FN6XJ	GO:0004672	24/85	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8FN6XJ	GO:0004383	23/85	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG8FN6XJ	GO:0008284	1/85	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG8FN6XJ	GO:0016849	1/85	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG8FN6XJ	GO:0045931	1/85	positive regulation of mitotic cell cycle	biological_process	"Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8FN6XJ	GO:0005886	1/85	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8FN6XJ	GO:0009190	1/85	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG8FN6XJ	GO:0016772	1/85	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8FN6XJ	GO:0004872	1/85	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8FN6XJ	GO:0045792	1/85	negative regulation of cell size	biological_process	"Any process that reduces cell size." [GOC:go_curators]
EOG8FN6XJ	GO:0007030	1/85	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8FN6XJ	GO:0007165	1/85	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG85QKTC	GO:0016021	1/23	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KPWT0	GO:0010826	24/79	negative regulation of centrosome duplication	biological_process	"Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]
EOG8KPWT0	GO:0042384	24/79	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8KPWT0	GO:0036038	24/79	TCTN-B9D complex	cellular_component	"A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins." [GOC:sp, PMID:21725307, PMID:22179047]
EOG8KPWT0	GO:0051726	1/79	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG85QKTN	GO:0003950	1/59	NAD+ ADP-ribosyltransferase activity	molecular_function	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]
EOG8NW20B	GO:0007165	22/106	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8NW20B	GO:0005856	21/106	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8NW20B	GO:0005622	2/106	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8NW20B	GO:0032855	1/106	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8NW20B	GO:0016199	1/106	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG8NW20B	GO:0030675	1/106	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8NW20B	GO:0007411	1/106	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8NW20B	GO:0005737	1/106	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG85QKTS	GO:0016020	18/93	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG85QKTS	GO:0008045	1/93	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG85QKTW	GO:0005634	19/122	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85QKTW	GO:0008270	18/122	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG85QKTW	GO:0003676	6/122	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85QKTW	GO:0046872	4/122	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8KM1H5	GO:0051539	24/91	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8KM1H5	GO:0009451	24/91	RNA modification	biological_process	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]
EOG8KM1H5	GO:0016740	23/91	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8KM1H5	GO:0032440	2/91	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8KM1H5	GO:0003824	2/91	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8KM1H5	GO:0000079	1/91	regulation of cyclin-dependent protein serine/threonine kinase activity	biological_process	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]
EOG8KM1H5	GO:0046872	1/91	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8KM1H5	GO:0051536	1/91	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8SR0BQ	GO:0008233	1/47	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8KM1HC	GO:0000166	26/125	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8KM1HC	GO:0003676	25/125	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KM1HC	GO:0030529	2/125	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8KM1HC	GO:0019013	2/125	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8KM1HC	GO:0000398	1/125	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8KM1HC	GO:0005509	1/125	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8KM1HC	GO:0035770	1/125	ribonucleoprotein granule	cellular_component	"A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]
EOG8KM1HC	GO:0046011	1/125	regulation of oskar mRNA translation	biological_process	"Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512]
EOG8KM1HC	GO:0007310	1/125	oocyte dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8KM1HC	GO:0016491	1/125	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8KM1HC	GO:0071011	1/125	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8KM1HC	GO:0022008	1/125	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8KM1HC	GO:0046843	1/125	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8KM1HC	GO:0003729	1/125	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8KM1HB	GO:0009987	1/97	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8KM1HB	GO:0022008	1/97	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8KM1HD	GO:0005524	34/101	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KM1HD	GO:0006457	34/101	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8KM1HD	GO:0005737	27/101	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8KM1HD	GO:0022008	1/101	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8KM1HD	GO:0051298	1/101	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8KM1HD	GO:0072686	1/101	mitotic spindle	cellular_component	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
EOG8KM1HD	GO:0031122	1/101	cytoplasmic microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
EOG8KM1HD	GO:0005811	1/101	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8KM1HD	GO:0007052	1/101	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8KM1HD	GO:0005875	1/101	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8MGVQJ	GO:0051568	1/78	histone H3-K4 methylation	biological_process	"The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai]
EOG8MGVQJ	GO:0044666	1/78	MLL3/4 complex	cellular_component	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]
EOG8MGVQJ	GO:0048188	1/78	Set1C/COMPASS complex	cellular_component	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]
EOG8MGVQJ	GO:0030317	1/78	sperm motility	biological_process	"Any process involved in the controlled movement of a sperm cell." [GOC:jl]
EOG8MGVQJ	GO:0046331	1/78	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8MGVQJ	GO:0006351	1/78	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8MGVQJ	GO:0006355	1/78	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85QKT0	GO:0005634	1/104	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85QKT0	GO:0005515	1/104	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG85QKT0	GO:0006351	1/104	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG85QKT0	GO:0001104	1/104	RNA polymerase II transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG85QKT0	GO:0006367	1/104	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG85QKT0	GO:0006357	1/104	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG85QKT0	GO:0006355	1/104	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85QKT0	GO:0016592	1/104	mediator complex	cellular_component	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
EOG85QKT4	GO:0005319	22/91	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG85QKT4	GO:0042157	1/91	lipoprotein metabolic process	biological_process	"The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732]
EOG85QKT4	GO:0015914	1/91	phospholipid transport	biological_process	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]
EOG85QKT4	GO:0035149	1/91	lumen formation, open tracheal system	biological_process	"Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
EOG85QKT4	GO:0048813	1/91	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG85QKT4	GO:0008525	1/91	phosphatidylcholine transporter activity	molecular_function	"Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732]
EOG85QKT4	GO:0005811	1/91	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG85QKT4	GO:0008039	1/91	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8KM1HR	GO:0005524	1/4	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KM1HR	GO:0003677	1/4	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8KM1HR	GO:0006265	1/4	DNA topological change	biological_process	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]
EOG8KM1HR	GO:0003918	1/4	DNA topoisomerase type II (ATP-hydrolyzing) activity	molecular_function	"Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192]
EOG8KM1HR	GO:0005694	1/4	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8KM1HT	GO:0006096	47/135	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8KM1HT	GO:0004739	47/135	pyruvate dehydrogenase (acetyl-transferring) activity	molecular_function	"Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1]
EOG8KM1HT	GO:0043231	46/135	intracellular membrane-bounded organelle	cellular_component	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
EOG8KM1HT	GO:0016624	3/135	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]
EOG8KM1HT	GO:0005739	1/135	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8BGCBP	GO:0019013	2/55	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8BGCBP	GO:0030529	2/55	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8BGCBP	GO:0008270	1/55	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BGCBP	GO:0004222	1/55	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8SFCMG	GO:0046872	28/91	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8SFCMG	GO:0048227	1/91	plasma membrane to endosome transport	biological_process	"Transport of a vesicle from the plasma membrane to the endosome." [GOC:jid]
EOG8SFCMG	GO:0005769	1/91	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG8SFCMG	GO:0001737	1/91	establishment of imaginal disc-derived wing hair orientation	biological_process	"Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]
EOG8SFCMG	GO:0031267	1/91	small GTPase binding	molecular_function	"Interacting selectively and non-covalently with a small monomeric GTPase." [GOC:mah]
EOG8SFCMG	GO:0045451	1/91	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8SFCMG	GO:0034058	1/91	endosomal vesicle fusion	biological_process	"The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]
EOG8SFCMG	GO:0030100	1/91	regulation of endocytosis	biological_process	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]
EOG8SFCMG	GO:0008103	1/91	oocyte microtubule cytoskeleton polarization	biological_process	"Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042]
EOG8SFCMG	GO:0005515	1/91	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8SFCMG	GO:0006897	1/91	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8SFCMG	GO:0005768	1/91	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG8909SX	GO:0003677	2/12	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8909SX	GO:0005634	2/12	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SR0DR	GO:0004519	2/36	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8SR0DR	GO:0003964	2/36	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG87DCZQ	GO:0005506	6/10	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG87DCZQ	GO:0020037	6/10	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG87DCZQ	GO:0019825	6/10	oxygen binding	molecular_function	"Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl]
EOG87DCZQ	GO:0005344	5/10	oxygen transporter activity	molecular_function	"Enables the directed movement of oxygen into, out of or within a cell, or between cells." [GOC:ai]
EOG87DCZQ	GO:0015671	1/10	oxygen transport	biological_process	"The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8909SJ	GO:0007218	1/34	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8BGCBC	GO:0005272	54/94	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8BGCBC	GO:0016021	52/94	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BGCBC	GO:0016020	2/94	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8BGCBC	GO:0035199	1/94	salt aversion	biological_process	"The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf]
EOG8BGCBC	GO:0035002	1/94	liquid clearance, open tracheal system	biological_process	"The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352]
EOG8BGCBC	GO:0009651	1/94	response to salt stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]
EOG8BGCBC	GO:0050914	1/94	sensory perception of salty taste	biological_process	"The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8JQ6BF	GO:0005524	14/81	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8JQ6BF	GO:0017111	12/81	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8JQ6BF	GO:0003677	2/81	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8JQ6BF	GO:0022008	1/81	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8JQ6BK	GO:0003824	242/458	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8JQ6BK	GO:0032504	4/458	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8JQ6BK	GO:0005615	3/458	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8JQ6BK	GO:0055085	2/458	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8JQ6BK	GO:0016021	2/458	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87DCZC	GO:0019992	4/52	diacylglycerol binding	molecular_function	"Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids." [GOC:ma]
EOG87DCZC	GO:0007268	4/52	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8FXTNJ	GO:0046856	12/78	phosphatidylinositol dephosphorylation	biological_process	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]
EOG8FXTNJ	GO:0004439	2/78	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36, RHEA:22767]
EOG8FXTNJ	GO:0046030	1/78	inositol trisphosphate phosphatase activity	molecular_function	"Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate." [GOC:bf]
EOG8FXTNJ	GO:0016311	1/78	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG8P2SH7	GO:0003677	28/115	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8P2SH7	GO:0003887	28/115	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8P2SH7	GO:0005634	1/115	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8P2SH7	GO:0006974	1/115	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8P2SH7	GO:0007052	1/115	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8P2SH7	GO:0005875	1/115	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8FXTNG	GO:0003676	1/106	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FXTNZ	GO:0006412	25/92	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8FXTNZ	GO:0005840	25/92	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8FXTNZ	GO:0003735	25/92	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8FXTNZ	GO:0007052	1/92	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8FXTNZ	GO:0051297	1/92	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8FXTNZ	GO:0051298	1/92	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8FXTNZ	GO:0000022	1/92	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8XSP6B	GO:0003676	57/550	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XSP6B	GO:0008270	55/550	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XSP6B	GO:0003723	11/550	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8XSP6B	GO:0003964	11/550	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8XSP6B	GO:0004190	5/550	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8XSP6B	GO:0005882	4/550	intermediate filament	cellular_component	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
EOG8XSP6B	GO:0005198	4/550	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8XSP6B	GO:0006355	1/550	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8XSP6B	GO:0016787	1/550	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8XSP6B	GO:0015074	1/550	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8XSP6B	GO:0005634	1/550	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PCD80	GO:0003964	2/12	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8PCD80	GO:0003723	1/12	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8K9DTW	GO:0006334	4/18	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8K9DTW	GO:0000786	4/18	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8K9DTW	GO:0003677	4/18	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8K9DTW	GO:0005634	4/18	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8K9DTW	GO:0008270	3/18	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TXF6D	GO:0006807	29/98	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG8TXF6D	GO:0016810	27/98	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
EOG8TXF6D	GO:0003837	3/98	beta-ureidopropionase activity	molecular_function	"Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6]
EOG8TXF6D	GO:0006208	1/98	pyrimidine nucleobase catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [CHEBI:26432, GOC:go_curators]
EOG8TXF6D	GO:0006207	1/98	'de novo' pyrimidine nucleobase biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]
EOG8SFCQ2	GO:0005525	2/9	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8THZ9T	GO:0016791	2/20	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG8THZ9T	GO:0004035	1/20	alkaline phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1]
EOG8R52GJ	GO:0003774	28/99	motor activity	molecular_function	"Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
EOG8R52GJ	GO:0016459	28/99	myosin complex	cellular_component	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
EOG8R52GJ	GO:0005524	28/99	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8R52GJ	GO:0032440	1/99	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8R52GJ	GO:0006886	1/99	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8R52GJ	GO:0007291	1/99	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8R52GJ	GO:0003779	1/99	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8R52GJ	GO:0045856	1/99	positive regulation of pole plasm oskar mRNA localization	biological_process	"Any process that activates or increases the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8R52GJ	GO:0030048	1/99	actin filament-based movement	biological_process	"Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah]
EOG8R52GJ	GO:0030898	1/99	actin-dependent ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate." [GOC:mah]
EOG8R52GJ	GO:0008595	1/99	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8R52GJ	GO:0006200	1/99	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8R52GJ	GO:0042052	1/99	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8R52GJ	GO:0031475	1/99	myosin V complex	cellular_component	"A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8R52GJ	GO:0016028	1/99	rhabdomere	cellular_component	"The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774]
EOG8R52GJ	GO:0043565	1/99	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8R52GJ	GO:0043025	1/99	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8R52GJ	GO:0042623	1/99	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8R52GJ	GO:0008270	1/99	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8R52GJ	GO:0005634	1/99	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8R52GJ	GO:0005516	1/99	calmodulin binding	molecular_function	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
EOG8R52GJ	GO:0047497	1/99	mitochondrion transport along microtubule	biological_process	"The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd]
EOG8R52GJ	GO:0032027	1/99	myosin light chain binding	molecular_function	"Interacting selectively and non-covalently with a light chain of a myosin complex." [GOC:mah]
EOG8R52GJ	GO:0003700	1/99	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8THZ9P	GO:0009058	2/5	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG8THZ9P	GO:0004317	1/5	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.61]
EOG8THZ9P	GO:0004314	1/5	[acyl-carrier-protein] S-malonyltransferase activity	molecular_function	"Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39]
EOG8THZ9P	GO:0016295	1/5	myristoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14, MetaCyc:RXN-10727]
EOG8THZ9P	GO:0004319	1/5	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	molecular_function	"Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10]
EOG8THZ9P	GO:0004312	1/5	fatty acid synthase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85]
EOG8THZ9P	GO:0004316	1/5	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
EOG8THZ9P	GO:0004315	1/5	3-oxoacyl-[acyl-carrier-protein] synthase activity	molecular_function	"Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.41]
EOG8THZ9P	GO:0016296	1/5	palmitoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14, MetaCyc:RXN-9549]
EOG8THZ9P	GO:0004313	1/5	[acyl-carrier-protein] S-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38]
EOG8THZ9P	GO:0004320	1/5	oleoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14]
EOG8THZ9P	GO:0016788	1/5	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG84QWFC	GO:0004725	25/101	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG84QWFC	GO:0005856	24/101	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG84QWFC	GO:0005737	1/101	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84QWFC	GO:0035331	1/101	negative regulation of hippo signaling	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf]
EOG84QWFC	GO:0006470	1/101	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG84QWFC	GO:0005938	1/101	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG84QWFC	GO:0008092	1/101	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG84QWFC	GO:0019898	1/101	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG84QWFC	GO:2000647	1/101	negative regulation of stem cell proliferation	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph]
EOG84QWFC	GO:0045177	1/101	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG84QWFC	GO:0050254	1/101	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG84QWFC	GO:0035335	1/101	peptidyl-tyrosine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
EOG85F05Q	GO:0016787	1/13	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8DZ49Z	GO:0003676	6/41	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BZQJC	GO:0016021	21/71	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BZQJC	GO:0005524	1/71	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8BZQJC	GO:0015416	1/71	organic phosphonate transmembrane-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:3.6.3.28]
EOG8BZQJC	GO:0005829	1/71	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8N5ZBP	GO:0050661	42/135	NADP binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]
EOG8N5ZBP	GO:0006006	42/135	glucose metabolic process	biological_process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]
EOG8N5ZBP	GO:0051287	42/135	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8N5ZBP	GO:0004365	32/135	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	molecular_function	"Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12]
EOG8N5ZBP	GO:0016620	14/135	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG8N5ZBP	GO:0006096	3/135	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8N5ZBP	GO:0005737	2/135	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8N5ZBP	GO:0005811	2/135	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8N5ZBP	GO:0030018	1/135	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8N5ZBP	GO:0005875	1/135	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8N5ZBP	GO:0031430	1/135	M band	cellular_component	"The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194]
EOG8N5ZBG	GO:0003824	13/77	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8N5ZBG	GO:0006470	10/77	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8N5ZBG	GO:0004722	10/77	protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
EOG8N5ZBG	GO:0046872	9/77	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8N5ZBG	GO:0016301	2/77	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8N5ZBG	GO:0004721	1/77	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8N5ZBF	GO:0006541	33/106	glutamine metabolic process	biological_process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
EOG8N5ZBF	GO:0008242	32/106	omega peptidase activity	molecular_function	"Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-]
EOG8N5ZBF	GO:0034722	1/106	gamma-glutamyl-peptidase activity	molecular_function	"Catalysis of the cleavage of a gamma-linked glutamate bond." [EC:3.4.19.9, MEROPS_fam:C26]
EOG8N5ZBD	GO:0050662	30/95	coenzyme binding	molecular_function	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
EOG8N5ZBD	GO:0008446	24/95	GDP-mannose 4,6-dehydratase activity	molecular_function	"Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O." [EC:4.2.1.47, RHEA:23823]
EOG8N5ZBD	GO:0019673	24/95	GDP-mannose metabolic process	biological_process	"The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
EOG8N5ZBD	GO:0005622	24/95	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8N5ZBD	GO:0003824	6/95	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8N5ZBD	GO:0044237	5/95	cellular metabolic process	biological_process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
EOG8N5ZBD	GO:0007219	1/95	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8N5ZBD	GO:2000035	1/95	regulation of stem cell division	biological_process	"Any process that modulates the frequency, rate or extent of stem cell division." [GOC:obol]
EOG8N5ZBD	GO:0005634	1/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8N5ZBD	GO:0042351	1/95	'de novo' GDP-L-fucose biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271)." [EC:1.1.1.271, PMID:11030750]
EOG8N5ZBD	GO:0042350	1/95	GDP-L-fucose biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:jl]
EOG8N5ZBD	GO:0048477	1/95	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8N5ZBD	GO:0006334	1/95	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8N5ZBC	GO:0016021	3/100	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8N5ZBC	GO:0007420	1/100	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG8THZ90	GO:0003676	1/8	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WM77J	GO:0006886	5/74	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8WM77J	GO:0005634	3/74	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PCD8W	GO:0005576	1/82	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8PCD8W	GO:0019991	1/82	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG8PCD8W	GO:0046658	1/82	anchored component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG8PCD8W	GO:0035152	1/82	regulation of tube architecture, open tracheal system	biological_process	"Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584]
EOG8WM77W	GO:0008270	7/106	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WM77W	GO:0003676	2/106	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WM77W	GO:0010212	1/106	response to ionizing radiation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526]
EOG8WM77W	GO:0006260	1/106	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8WM77W	GO:0005634	1/106	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WM77W	GO:0015074	1/106	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8WM77W	GO:0033314	1/106	mitotic DNA replication checkpoint	biological_process	"A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mtg_cell_cycle]
EOG8K9DT0	GO:0016021	3/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8K9DT0	GO:0005452	3/9	inorganic anion exchanger activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah]
EOG8WM77S	GO:0016197	1/97	endosomal transport	biological_process	"The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]
EOG8WM77S	GO:0008333	1/97	endosome to lysosome transport	biological_process	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]
EOG8WM77S	GO:0016021	1/97	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Q5C4Z	GO:0008270	29/245	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q5C4Z	GO:0003676	26/245	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q5C4Z	GO:0003964	4/245	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8Q5C4Z	GO:0003723	4/245	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG81G5JG	GO:0033596	1/88	TSC1-TSC2 complex	cellular_component	"A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway." [PMID:10585443, PMID:17121544, PMID:9580671]
EOG81G5JG	GO:0007584	1/88	response to nutrient	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators]
EOG81G5JG	GO:0032320	1/88	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG81G5JG	GO:0005829	1/88	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG81G5JG	GO:0019900	1/88	kinase binding	molecular_function	"Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]
EOG81G5JG	GO:0032007	1/88	negative regulation of TOR signaling	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG81G5JG	GO:0045792	1/88	negative regulation of cell size	biological_process	"Any process that reduces cell size." [GOC:go_curators]
EOG81G5JG	GO:0030308	1/88	negative regulation of cell growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG81G5JG	GO:0032956	1/88	regulation of actin cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]
EOG81G5JG	GO:0035069	1/88	larval midgut histolysis	biological_process	"The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683]
EOG81G5JG	GO:0042325	1/88	regulation of phosphorylation	biological_process	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]
EOG81G5JG	GO:0071456	1/88	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG81G5JG	GO:0048640	1/88	negative regulation of developmental growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators]
EOG81G5JG	GO:0060439	1/88	trachea morphogenesis	biological_process	"The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG81G5JG	GO:0051726	1/88	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG81G5JG	GO:0005515	1/88	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG81G5JG	GO:0046620	1/88	regulation of organ growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
EOG81G5JG	GO:0008340	1/88	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG81G5JG	GO:0008285	1/88	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG81G5JG	GO:2000377	1/88	regulation of reactive oxygen species metabolic process	biological_process	"Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]
EOG81G5JG	GO:0035883	1/88	enteroendocrine cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system." [CL:0000164, GOC:bf]
EOG81G5JG	GO:0036335	1/88	intestinal stem cell homeostasis	biological_process	"Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells." [GOC:nhn, PMID:22042863]
EOG81G5JG	GO:0019901	1/88	protein kinase binding	molecular_function	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]
EOG81G5JG	GO:0001558	1/88	regulation of cell growth	biological_process	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG81G5JG	GO:0038202	1/88	TORC1 signaling	biological_process	"A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]
EOG81G5JG	GO:0048505	1/88	regulation of timing of cell differentiation	biological_process	"The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb]
EOG81G5JG	GO:0046627	1/88	negative regulation of insulin receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG81G5JG	GO:0006629	1/88	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG81G5JG	GO:0005737	1/88	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG81G5JG	GO:0046621	1/88	negative regulation of organ growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
EOG81G5JG	GO:0030695	1/88	GTPase regulator activity	molecular_function	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
EOG81G5JG	GO:0008286	1/88	insulin receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]
EOG81G5JG	GO:0007165	1/88	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG81G5JG	GO:0042127	1/88	regulation of cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
EOG8R52GV	GO:0006464	26/89	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG8R52GV	GO:0005524	2/89	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8R52GV	GO:0004835	1/89	tubulin-tyrosine ligase activity	molecular_function	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]
EOG8G4K4S	GO:0005525	23/86	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8G4K4S	GO:0003924	21/86	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8G4K4S	GO:0006400	21/86	tRNA modification	biological_process	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]
EOG8G4K4S	GO:0005622	21/86	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8G4K4S	GO:0016020	1/86	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8G4K4S	GO:0000155	1/86	phosphorelay sensor kinase activity	molecular_function	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
EOG8VX4M0	GO:0008270	76/1021	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VX4M0	GO:0003676	72/1021	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VX4M0	GO:0003964	70/1021	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8VX4M0	GO:0015074	70/1021	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8VX4M0	GO:0003723	69/1021	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8VX4M0	GO:0005198	14/1021	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8VX4M0	GO:0005882	14/1021	intermediate filament	cellular_component	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
EOG8VX4M0	GO:0004190	10/1021	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8VX4M0	GO:0003677	4/1021	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8VX4M0	GO:0005634	2/1021	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BP3RQ	GO:0005524	26/105	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8BP3RQ	GO:0004822	26/105	isoleucine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.5, RHEA:11063]
EOG8BP3RQ	GO:0002161	26/105	aminoacyl-tRNA editing activity	molecular_function	"The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889]
EOG8BP3RQ	GO:0006428	25/105	isoleucyl-tRNA aminoacylation	biological_process	"The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8BP3RQ	GO:0005737	25/105	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8BP3RQ	GO:0005975	1/105	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8BP3RQ	GO:0006418	1/105	tRNA aminoacylation for protein translation	biological_process	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]
EOG8BP3RQ	GO:0004553	1/105	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8G4K4K	GO:0003707	27/108	steroid hormone receptor activity	molecular_function	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
EOG8G4K4K	GO:0005634	27/108	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8G4K4K	GO:0004887	25/108	thyroid hormone receptor activity	molecular_function	"Combining with thyroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling]
EOG8G4K4K	GO:0008270	23/108	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8G4K4K	GO:0043565	22/108	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8G4K4K	GO:0003677	4/108	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8G4K4K	GO:0046872	4/108	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8G4K4K	GO:0006351	2/108	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8G4K4K	GO:0003700	2/108	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8G4K4K	GO:0040034	1/108	regulation of development, heterochronic	biological_process	"Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909]
EOG8G4K4K	GO:0030522	1/108	intracellular receptor signaling pathway	biological_process	"Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah]
EOG8G4K4K	GO:0045944	1/108	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8G4K4K	GO:0000122	1/108	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8G4K4K	GO:0016319	1/108	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8G4K4K	GO:0005515	1/108	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8G4K4K	GO:0004879	1/108	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	molecular_function	"Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH]
EOG8G4K4K	GO:0007552	1/108	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG8G4K4K	GO:0000977	1/108	RNA polymerase II regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
EOG8PP11J	GO:0005215	1/2	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8PP11J	GO:0016021	1/2	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PP11J	GO:0008658	1/2	penicillin binding	molecular_function	"Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai]
EOG8Q5C4N	GO:0016021	25/100	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Q5C4N	GO:0015385	24/100	sodium:proton antiporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-]
EOG8Q5C4N	GO:0006885	24/100	regulation of pH	biological_process	"Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8Q5C4N	GO:0015299	1/100	solute:proton antiporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]
EOG8Q5C4N	GO:0048471	1/100	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG83XXK4	GO:0003676	5/25	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83XXK4	GO:0015074	4/25	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG83XXK4	GO:0003964	1/25	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG83XXK4	GO:0003723	1/25	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8Q5C4B	GO:0003677	19/328	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Q5C4B	GO:0000166	18/328	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8Q5C4B	GO:0008408	18/328	3'-5' exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]
EOG8Q5C4B	GO:0003887	18/328	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8Q5C4B	GO:0006298	6/328	mismatch repair	biological_process	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
EOG8Q5C4B	GO:0004519	6/328	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8Q5C4B	GO:0006353	3/328	DNA-templated transcription, termination	biological_process	"The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161]
EOG8Q5C4B	GO:0003676	2/328	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q5C4B	GO:0003964	1/328	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8Q5C4B	GO:0006355	1/328	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Q5C4B	GO:0003723	1/328	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8JMB4V	GO:0008270	1/84	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8JMB4V	GO:0072572	1/84	poly-ADP-D-ribose binding	molecular_function	"Interacting selectively and non-covalently with polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring." [CHEBI:61151, GOC:mah, GOC:sart, PMID:20088964]
EOG841SWV	GO:0005622	2/2	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG841SWV	GO:0004198	2/2	calcium-dependent cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]
EOG8F7R02	GO:0003676	25/92	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8F7R02	GO:0004527	23/92	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8F7R02	GO:0008859	1/92	exoribonuclease II activity	molecular_function	"Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684]
EOG8PG8FK	GO:0035556	2/12	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8PG8FK	GO:0009190	2/12	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG8PG8FK	GO:0016849	2/12	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG8F7R00	GO:0016021	23/89	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F7R00	GO:0005886	15/89	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8F7R00	GO:0048477	15/89	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8F7R00	GO:0007283	15/89	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8F7R00	GO:0044332	1/89	Wnt signaling pathway involved in dorsal/ventral axis specification	biological_process	"The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the establishment, maintenance and elaboration of the dorsal/ventral axis." [GOC:jl, GOC:yaf]
EOG8F7R00	GO:0042813	1/89	Wnt-activated receptor activity	molecular_function	"Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators]
EOG8F7R00	GO:0007285	1/89	primary spermatocyte growth	biological_process	"The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jid, ISBN:0879694238]
EOG8F7R00	GO:0060070	1/89	canonical Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488]
EOG8F7R00	GO:0017147	1/89	Wnt-protein binding	molecular_function	"Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]
EOG8PG8FF	GO:0008270	23/87	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PG8FF	GO:0008340	1/87	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8PG8FF	GO:0060548	1/87	negative regulation of cell death	biological_process	"Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]
EOG8PG8FF	GO:0016567	1/87	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8PG8FF	GO:0007390	1/87	germ-band shortening	biological_process	"The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138]
EOG8PG8FF	GO:0022407	1/87	regulation of cell-cell adhesion	biological_process	"Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete]
EOG8PG8FF	GO:0004842	1/87	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8PG8FF	GO:0008258	1/87	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8PG8FF	GO:0007391	1/87	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8PG8FF	GO:0030159	1/87	receptor signaling complex scaffold activity	molecular_function	"Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]
EOG8PG8FB	GO:0004984	32/125	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8PG8FB	GO:0005549	32/125	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8PG8FB	GO:0016021	31/125	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PG8FB	GO:0004930	30/125	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8PG8FB	GO:0005886	26/125	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8PG8FB	GO:0050911	2/125	detection of chemical stimulus involved in sensory perception of smell	biological_process	"The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8PG8FB	GO:0016020	2/125	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8PG8FB	GO:0007608	2/125	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8PG8FB	GO:0042048	1/125	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG8PG8FB	GO:0008104	1/125	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8PG8FB	GO:0004888	1/125	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8PG8FB	GO:0043025	1/125	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8PG8FB	GO:0030425	1/125	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8PG8FB	GO:0008527	1/125	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8F7R0G	GO:0035091	8/45	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG8VQD37	GO:0042132	28/180	fructose 1,6-bisphosphate 1-phosphatase activity	molecular_function	"Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.11]
EOG8VQD37	GO:0005975	27/180	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8VQD37	GO:0006886	23/180	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8VQD37	GO:0016192	23/180	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8VQD37	GO:0008270	20/180	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VQD37	GO:0006727	1/180	ommochrome biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
EOG8VQD37	GO:0035556	1/180	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8VQD37	GO:0006487	1/180	protein N-linked glycosylation	biological_process	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]
EOG8VQD37	GO:0007041	1/180	lysosomal transport	biological_process	"The directed movement of substances into, out of or within a lysosome." [GOC:ai]
EOG8VQD37	GO:0006897	1/180	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8VQD37	GO:0030897	1/180	HOPS complex	cellular_component	"A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161]
EOG8VQD37	GO:0008340	1/180	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8VQD37	GO:0016020	1/180	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8VQD37	GO:0007220	1/180	Notch receptor processing	biological_process	"The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]
EOG8VQD37	GO:0035542	1/180	regulation of SNARE complex assembly	biological_process	"Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
EOG8VQD37	GO:0033227	1/180	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8VQD37	GO:0003830	1/180	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144]
EOG8VQD37	GO:0046907	1/180	intracellular transport	biological_process	"The directed movement of substances within a cell." [GOC:ai]
EOG8VQD33	GO:0051276	26/104	chromosome organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8VQD33	GO:0005524	26/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VQD33	GO:0005694	25/104	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8VQD33	GO:0006310	4/104	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8VQD33	GO:0006281	4/104	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8VQD33	GO:0005634	4/104	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VQD33	GO:0008278	1/104	cohesin complex	cellular_component	"A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:sp, PMID:9887095]
EOG8VQD33	GO:0022008	1/104	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8VQD33	GO:0046331	1/104	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8VQD33	GO:0007476	1/104	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8VQD33	GO:0001737	1/104	establishment of imaginal disc-derived wing hair orientation	biological_process	"Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]
EOG8PG8F1	GO:0030163	5/12	protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]
EOG8PG8F1	GO:0004252	5/12	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8PG8F1	GO:0004176	5/12	ATP-dependent peptidase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah]
EOG8PG8F1	GO:0005524	5/12	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VQD38	GO:0016021	2/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VQD38	GO:0005509	1/9	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8F7R0V	GO:0071632	1/94	optomotor response	biological_process	"Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish." [GOC:dos, PMID:12726833, PMID:2469195]
EOG8F7R0V	GO:0007630	1/94	jump response	biological_process	"The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jid, ISBN:0198606907]
EOG8F7R0V	GO:0034551	1/94	mitochondrial respiratory chain complex III assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc]
EOG8F7R0V	GO:0016491	1/94	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8F7R0V	GO:0005739	1/94	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8F7R0V	GO:0097033	1/94	mitochondrial respiratory chain complex III biogenesis	biological_process	"The biogenesis of a mitochondrial respiratory chain complex III (also known as cytochrome bc(1) complex or ubiquinol-cytochrome c reductase), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mcc]
EOG8ZPH9W	GO:0005524	2/20	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZPH9W	GO:0016887	2/20	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG847J95	GO:0000166	25/85	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG847J95	GO:0003676	24/85	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG847J95	GO:0005634	1/85	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG847J95	GO:0071013	1/85	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG847J95	GO:0007095	1/85	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG847J95	GO:0000398	1/85	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG847J95	GO:0005515	1/85	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG847J95	GO:0003729	1/85	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG847J95	GO:0022008	1/85	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG847J95	GO:0071011	1/85	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG847J95	GO:0006376	1/85	mRNA splice site selection	biological_process	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]
EOG8K0T69	GO:0005509	1/2	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8F7R0Z	GO:0003676	1/88	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8G4K48	GO:0030529	4/94	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8G4K48	GO:0019013	3/94	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8G4K48	GO:0003723	2/94	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8G4K48	GO:0005829	1/94	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8G4K48	GO:0005634	1/94	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8G4K48	GO:0006396	1/94	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8G4K48	GO:0000001	1/94	mitochondrion inheritance	biological_process	"The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764]
EOG8G4K48	GO:0035186	1/94	syncytial blastoderm mitotic cell cycle	biological_process	"Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238]
EOG8G4K48	GO:0005737	1/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8G4K48	GO:0048102	1/94	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8G4K48	GO:0035071	1/94	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8G4K48	GO:0007053	1/94	spindle assembly involved in male meiosis	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah]
EOG8G4K48	GO:0007140	1/94	male meiosis	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
EOG87Q0KZ	GO:0010181	1/7	FMN binding	molecular_function	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]
EOG87Q0KZ	GO:0016491	1/7	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG87Q0KZ	GO:0016020	1/7	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG83BQ33	GO:0004177	167/275	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG83BQ33	GO:0005737	163/275	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83BQ33	GO:0030145	163/275	manganese ion binding	molecular_function	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
EOG83BQ33	GO:0008235	163/275	metalloexopeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]
EOG83BQ33	GO:0005622	4/275	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG83BQ33	GO:0005615	1/275	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG83BQ33	GO:0003676	1/275	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83BQ33	GO:0032504	1/275	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG83BQ33	GO:0016319	1/275	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG83BQ33	GO:0016706	1/275	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG83BQ33	GO:0007498	1/275	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG83BQ33	GO:0015074	1/275	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG87Q0KX	GO:0004930	24/111	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG87Q0KX	GO:0016021	24/111	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87Q0KX	GO:0008324	1/111	cation transmembrane transporter activity	molecular_function	"Enables the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
EOG87Q0KX	GO:0005886	1/111	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8Q5C47	GO:0003964	34/377	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8Q5C47	GO:0003723	27/377	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8Q5C47	GO:0046872	14/377	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Q5C47	GO:0003677	7/377	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Q5C47	GO:0008270	3/377	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q5C47	GO:0003676	2/377	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q5C47	GO:0006355	2/377	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Q5C47	GO:0004519	1/377	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8ZSCGZ	GO:0004721	2/100	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8ZSCGZ	GO:0010004	1/100	gastrulation involving germ band extension	biological_process	"A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8ZSCGZ	GO:0030239	1/100	myofibril assembly	biological_process	"Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]
EOG8ZSCGZ	GO:0006886	1/100	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8ZSCGZ	GO:0007629	1/100	flight behavior	biological_process	"The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
EOG8ZSCGZ	GO:0005741	1/100	mitochondrial outer membrane	cellular_component	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
EOG8ZSCGZ	GO:0007527	1/100	adult somatic muscle development	biological_process	"The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG8ZSCGZ	GO:0003779	1/100	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8Q5C44	GO:0003677	17/48	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Q5C44	GO:0003676	2/48	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RJJFR	GO:0000398	30/94	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8RJJFR	GO:0005681	29/94	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8RJJFR	GO:0071011	1/94	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8RJJFR	GO:0035214	1/94	eye-antennal disc development	biological_process	"Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8RJJFR	GO:0001700	1/94	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8RJJFR	GO:0005515	1/94	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8RJJFR	GO:0071013	1/94	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8RJJFR	GO:0003677	1/94	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8VX4MN	GO:0003682	4/48	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8P8J44	GO:0030246	1/4	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8P8J44	GO:0003700	1/4	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8P8J44	GO:0005975	1/4	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8P8J44	GO:0003677	1/4	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81G5J0	GO:0005524	23/96	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG81G5J0	GO:0004674	18/96	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG81G5J0	GO:0017111	6/96	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG81G5J0	GO:0005634	5/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81G5J0	GO:0008270	5/96	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81G5J0	GO:0003700	5/96	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8JMB42	GO:0016491	1/10	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8JMB42	GO:0003824	1/10	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8JMB45	GO:0005524	1/4	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8JMB45	GO:0008081	1/4	phosphoric diester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]
EOG8JMB45	GO:0004814	1/4	arginine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19]
EOG8JMB45	GO:0006420	1/4	arginyl-tRNA aminoacylation	biological_process	"The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8JMB45	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WDGTG	GO:0006974	1/83	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG83BQ32	GO:0006368	21/88	transcription elongation from RNA polymerase II promoter	biological_process	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
EOG83BQ32	GO:0008023	21/88	transcription elongation factor complex	cellular_component	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]
EOG83BQ32	GO:0043620	1/88	regulation of DNA-templated transcription in response to stress	biological_process	"Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl, GOC:txnOH]
EOG83BQ32	GO:0042795	1/88	snRNA transcription from RNA polymerase II promoter	biological_process	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382]
EOG83BQ32	GO:0005700	1/88	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG83BQ32	GO:0003682	1/88	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG83BQ32	GO:0048190	1/88	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8WDGTK	GO:0005198	5/216	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8WDGTK	GO:0019028	5/216	viral capsid	cellular_component	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
EOG8C2KRD	GO:0000166	42/109	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8C2KRD	GO:0005852	42/109	eukaryotic translation initiation factor 3 complex	cellular_component	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]
EOG8C2KRD	GO:0003743	42/109	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8C2KRD	GO:0016282	39/109	eukaryotic 43S preinitiation complex	cellular_component	"A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049]
EOG8C2KRD	GO:0001731	39/109	formation of translation preinitiation complex	biological_process	"The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd]
EOG8C2KRD	GO:0006446	39/109	regulation of translational initiation	biological_process	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG8C2KRD	GO:0033290	39/109	eukaryotic 48S preinitiation complex	cellular_component	"A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049]
EOG8C2KRD	GO:0008270	23/109	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8C2KRD	GO:0006413	2/109	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG8C2KRD	GO:0003729	2/109	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8C2KRD	GO:0051726	2/109	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8C2KRD	GO:0004252	1/109	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8C2KRD	GO:0007067	1/109	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8C2KRD	GO:0000022	1/109	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8C2KRD	GO:0007052	1/109	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8C2KRZ	GO:0005622	12/97	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8C2KRZ	GO:0007165	12/97	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8WDGTZ	GO:0016226	25/80	iron-sulfur cluster assembly	biological_process	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]
EOG8WDGTZ	GO:0005198	25/80	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8WDGTZ	GO:0051536	25/80	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8C2KRT	GO:0003993	96/479	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG8C2KRT	GO:0006909	1/479	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG81K1T5	GO:0051287	73/226	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG81K1T5	GO:0016616	67/226	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG81K1T5	GO:0030267	4/226	glyoxylate reductase (NADP) activity	molecular_function	"Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [EC:1.1.1.79]
EOG81K1T5	GO:0047964	2/226	glyoxylate reductase activity	molecular_function	"Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH." [EC:1.1.1.26, MetaCyc:GLYCOLATE-REDUCTASE-RXN]
EOG81K1T5	GO:0004617	1/226	phosphoglycerate dehydrogenase activity	molecular_function	"Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95]
EOG81K1T5	GO:0005576	1/226	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG81K1T5	GO:0048037	1/226	cofactor binding	molecular_function	"Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]
EOG81K1T5	GO:0003676	1/226	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84QWHN	GO:0008270	9/22	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84QWHN	GO:0016491	1/22	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8WHC10	GO:0016592	26/106	mediator complex	cellular_component	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
EOG8WHC10	GO:0001104	26/106	RNA polymerase II transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8WHC10	GO:0006366	1/106	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8WHC10	GO:0016021	1/106	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WHC10	GO:0006367	1/106	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG8WHC14	GO:0005975	86/174	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8WHC14	GO:0004568	85/174	chitinase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
EOG8WHC14	GO:0006032	84/174	chitin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8WHC14	GO:0005576	10/174	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8WHC14	GO:0007444	9/174	imaginal disc development	biological_process	"The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238]
EOG8WHC14	GO:0008084	9/174	imaginal disc growth factor receptor binding	molecular_function	"Interacting selectively and non-covalently with an imaginal disc growth factor receptor." [GOC:mah]
EOG8WHC14	GO:0007275	1/174	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8WHC14	GO:0006036	1/174	cuticle chitin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai]
EOG8WHC14	GO:0005615	1/174	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8WHC14	GO:0008061	1/174	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8WHC14	GO:0004553	1/174	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG81K1T9	GO:0003677	16/116	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81K1T9	GO:0006355	10/116	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG81K1T9	GO:0006351	9/116	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG81K1T9	GO:0051493	9/116	regulation of cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
EOG81K1T9	GO:0007366	9/116	periodic partitioning by pair rule gene	biological_process	"Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG81K1T9	GO:0032368	9/116	regulation of lipid transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG81K1T9	GO:0008361	9/116	regulation of cell size	biological_process	"Any process that modulates the size of a cell." [GOC:go_curators]
EOG81K1T9	GO:0042051	9/116	compound eye photoreceptor development	biological_process	"The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
EOG81K1T9	GO:0003700	9/116	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG81K1T9	GO:0005634	9/116	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81K1T9	GO:0007365	1/116	periodic partitioning	biological_process	"The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma]
EOG81K1T9	GO:0007611	1/116	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG81K1T9	GO:0048190	1/116	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG81K1T9	GO:0000915	1/116	actomyosin contractile ring assembly	biological_process	"The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
EOG81K1T9	GO:0032783	1/116	ELL-EAF complex	cellular_component	"A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae." [PMID:17150956]
EOG81K1T9	GO:0007379	1/116	segment specification	biological_process	"The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG81K1T9	GO:0042048	1/116	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG81K1T8	GO:0016209	1/3	antioxidant activity	molecular_function	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
EOG81K1T8	GO:0016491	1/3	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG880MBM	GO:0006869	2/90	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG880MBM	GO:0016740	1/90	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8NP9H8	GO:0007156	27/99	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8NP9H8	GO:0005509	27/99	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8NP9H8	GO:0016021	26/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NP9H8	GO:0005886	25/99	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8NP9H8	GO:0016324	1/99	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8NP9H8	GO:0004022	1/99	alcohol dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
EOG8NP9H8	GO:0016339	1/99	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
EOG8NP9H8	GO:0007304	1/99	chorion-containing eggshell formation	biological_process	"The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8NP9H8	GO:0005887	1/99	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NP9H8	GO:0032533	1/99	regulation of follicle cell microvillus length	biological_process	"A process that modulates the length of a microvillus on a follicle cell." [GOC:sart, PMID:16260500]
EOG8NP9H8	GO:0007224	1/99	smoothened signaling pathway	biological_process	"A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
EOG8NP9H8	GO:0032529	1/99	follicle cell microvillus organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. A microvillus is a thin cylindrical membrane-covered projection on the surface of an animal cell containing a core bundle of actin filaments." [GOC:sart, PMID:16507588]
EOG8NP9H8	GO:0005902	1/99	microvillus	cellular_component	"Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194]
EOG8NP9H8	GO:0007305	1/99	vitelline membrane formation involved in chorion-containing eggshell formation	biological_process	"Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG84QWHS	GO:0046872	2/13	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84QWHS	GO:0003676	2/13	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GF5VV	GO:0016772	5/67	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8GF5VV	GO:0016887	1/67	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8HMMRN	GO:0004222	16/959	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8HMMRN	GO:0005515	6/959	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8HMMRN	GO:0008270	1/959	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8HMMRN	GO:0046872	1/959	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HMMRN	GO:0003676	1/959	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NS5S5	GO:0003676	19/46	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NS5S5	GO:0005515	1/46	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8NS5S5	GO:0046872	1/46	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NS5S5	GO:0008270	1/46	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NS5S4	GO:0042302	21/73	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8NS5S4	GO:0008010	1/73	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8NS5S4	GO:0031012	1/73	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8NS5S4	GO:0040003	1/73	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG898XDQ	GO:0051013	1/131	microtubule severing	biological_process	"The process in which a microtubule is broken down into smaller segments." [GOC:ai, PMID:14657234]
EOG898XDQ	GO:0005737	1/131	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG898XDQ	GO:0000022	1/131	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG898XDQ	GO:0005816	1/131	spindle pole body	cellular_component	"The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome." [ISBN:0879693568]
EOG898XDQ	GO:0005819	1/131	spindle	cellular_component	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
EOG898XDQ	GO:0051011	1/131	microtubule minus-end binding	molecular_function	"Interacting selectively and non-covalently with the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]
EOG898XDQ	GO:0005813	1/131	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG898XDQ	GO:0007026	1/131	negative regulation of microtubule depolymerization	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]
EOG898XDQ	GO:0030496	1/131	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG898XDQ	GO:0005874	1/131	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8CJZ17	GO:0016192	1/8	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8CJZ17	GO:0016020	1/8	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG880MB7	GO:0003676	14/75	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG880MB7	GO:0003964	1/75	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG880MB7	GO:0003723	1/75	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8X6FQ2	GO:0016021	25/88	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X6FQ2	GO:0005319	25/88	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG880MB3	GO:0004833	27/112	tryptophan 2,3-dioxygenase activity	molecular_function	"Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11]
EOG880MB3	GO:0019441	27/112	tryptophan catabolic process to kynurenine	biological_process	"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]
EOG880MB3	GO:0020037	27/112	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG880MB3	GO:0046872	22/112	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG880MB3	GO:0006727	19/112	ommochrome biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
EOG880MB3	GO:0008234	3/112	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG880MB3	GO:0019442	2/112	tryptophan catabolic process to acetyl-CoA	biological_process	"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA." [GOC:go_curators]
EOG880MB3	GO:0006569	1/112	tryptophan catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684]
EOG880MB3	GO:0070189	1/112	kynurenine metabolic process	biological_process	"The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph]
EOG880MB3	GO:0048072	1/112	compound eye pigmentation	biological_process	"Establishment of a pattern of pigment in the compound eye." [GOC:jid]
EOG880MB3	GO:1901216	1/112	positive regulation of neuron death	biological_process	"Any process that activates or increases the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]
EOG8GF5V0	GO:0046427	1/49	positive regulation of JAK-STAT cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG8WHC1M	GO:0003677	2/34	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GF5V5	GO:0022900	35/131	electron transport chain	biological_process	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport]
EOG8GF5V5	GO:0006099	35/131	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8GF5V5	GO:0050660	35/131	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8GF5V5	GO:0016627	31/131	oxidoreductase activity, acting on the CH-CH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8GF5V5	GO:0016491	5/131	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8GF5V5	GO:0008177	4/131	succinate dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol." [EC:1.3.5.1, RHEA:13716]
EOG8GF5V5	GO:0005743	1/131	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8GF5V5	GO:0005739	1/131	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8NP9HS	GO:0016668	1/9	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG8NP9HS	GO:0004148	1/9	dihydrolipoyl dehydrogenase activity	molecular_function	"Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4]
EOG8NP9HS	GO:0045454	1/9	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8NP9HS	GO:0050660	1/9	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8NP9HS	GO:0016746	1/9	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG898XDH	GO:0046872	1/37	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8VT8BC	GO:0003824	1/101	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8VT8BC	GO:0035075	1/101	response to ecdysone	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf]
EOG8VT8BC	GO:0005737	1/101	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8VT8BC	GO:0008344	1/101	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG8VT8BC	GO:0005634	1/101	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VT8BC	GO:0006351	1/101	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8VT8BC	GO:0005515	1/101	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VT8BC	GO:0007275	1/101	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8VT8BC	GO:0004402	1/101	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8VT8BC	GO:0071254	1/101	cytoplasmic U snRNP body	cellular_component	"A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295]
EOG8VT8BC	GO:0007591	1/101	molting cycle, chitin-based cuticle	biological_process	"The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu]
EOG8VT8BC	GO:0006355	1/101	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8VT8BC	GO:0007629	1/101	flight behavior	biological_process	"The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
EOG8GQSK3	GO:0005234	23/60	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8GQSK3	GO:0016020	22/60	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8GQSK3	GO:0004970	22/60	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8GQSK3	GO:0050907	1/60	detection of chemical stimulus involved in sensory perception	biological_process	"The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
EOG8GQSK3	GO:0015276	1/60	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8GQSK3	GO:0034220	1/60	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8GQSK3	GO:0036081	1/60	extracellular ammonia-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
EOG8GQSK3	GO:0016021	1/60	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TQPQT	GO:0004518	4/8	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8TQPQT	GO:0003677	4/8	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TQPQT	GO:0005634	2/8	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TQPQT	GO:0016568	2/8	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG80CKWZ	GO:0031418	25/105	L-ascorbic acid binding	molecular_function	"Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]
EOG80CKWZ	GO:0005506	25/105	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG80CKWZ	GO:0016706	23/105	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG80CKWZ	GO:0008475	2/105	procollagen-lysine 5-dioxygenase activity	molecular_function	"Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4]
EOG80CKWZ	GO:0005581	2/105	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG80CKWZ	GO:0005615	1/105	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG80CKWZ	GO:0007295	1/105	growth of a germarium-derived egg chamber	biological_process	"Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG80CKWZ	GO:0005783	1/105	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG80CKWZ	GO:0048471	1/105	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8F20HT	GO:0016706	37/95	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG8F20HT	GO:0005506	5/95	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8GF5WP	GO:0030983	6/42	mismatched DNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]
EOG8GF5WP	GO:0006298	6/42	mismatch repair	biological_process	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
EOG8GF5WP	GO:0005524	6/42	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG83V28W	GO:0016021	27/98	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83V28W	GO:0033211	1/98	adiponectin-activated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of adiponectin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:20536390]
EOG83V28W	GO:0009755	1/98	hormone-mediated signaling pathway	biological_process	"A series of molecular signals mediated by the detection of a hormone." [GOC:sm]
EOG83V28W	GO:0042593	1/98	glucose homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]
EOG83V28W	GO:0005886	1/98	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG83V28W	GO:0032024	1/98	positive regulation of insulin secretion	biological_process	"Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah]
EOG83V28W	GO:0019395	1/98	fatty acid oxidation	biological_process	"The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732, MetaCyc:FAO-PWY]
EOG83V28W	GO:0004872	1/98	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG83V28W	GO:0070328	1/98	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG83V28W	GO:0042562	1/98	hormone binding	molecular_function	"Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
EOG844P1T	GO:0016491	32/117	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG844P1T	GO:0004090	2/117	carbonyl reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184]
EOG844P1T	GO:0000166	1/117	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8FXTQW	GO:0003676	4/9	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FXTQW	GO:0046872	4/9	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8FJBSQ	GO:0042302	4/31	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8WSZQD	GO:0008203	24/104	cholesterol metabolic process	biological_process	"The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues." [ISBN:0198506732]
EOG8WSZQD	GO:0016042	24/104	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8WSZQD	GO:0016298	23/104	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG8WSZQD	GO:0016787	10/104	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8WSZQD	GO:0033878	3/104	hormone-sensitive lipase activity	molecular_function	"Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate." [EC:3.1.1.79]
EOG8WSZQD	GO:0005811	1/104	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8WSZQD	GO:0016021	1/104	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WSZQD	GO:0006642	1/104	triglyceride mobilization	biological_process	"The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625]
EOG8WSZQD	GO:0004930	1/104	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8WSZQD	GO:0005829	1/104	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8WSZQD	GO:0004806	1/104	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG8WSZQG	GO:0005524	17/69	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WSZQG	GO:0016887	16/69	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8WSZQG	GO:0015408	1/69	ferric-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [EC:3.6.3.30]
EOG844P1B	GO:0008270	22/103	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG844P1B	GO:0031213	1/103	RSF complex	cellular_component	"An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters)." [GOC:krc, PMID:12972596, PMID:15284901, PMID:16568949, PMID:21810179]
EOG844P1B	GO:0005705	1/103	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG844P1B	GO:0004970	1/103	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG844P1B	GO:0003677	1/103	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG844P1B	GO:0070868	1/103	heterochromatin organization involved in chromatin silencing	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah]
EOG844P1B	GO:0005634	1/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG844P1B	GO:0005700	1/103	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG844P1B	GO:0016020	1/103	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG844P1B	GO:0005234	1/103	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8FXTQK	GO:0005871	2/5	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8FXTQK	GO:0007018	2/5	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8FXTQK	GO:0003777	2/5	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8FXTQK	GO:0005874	2/5	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8FXTQK	GO:0005524	2/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG844P1N	GO:0042623	1/86	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG844P1N	GO:0030286	1/86	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG844P1N	GO:0003774	1/86	motor activity	molecular_function	"Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
EOG844P1N	GO:0006200	1/86	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG844P1N	GO:0007018	1/86	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8B8MSV	GO:0007018	31/98	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8B8MSV	GO:0003777	31/98	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8B8MSV	GO:0001539	30/98	cilium or flagellum-dependent cell motility	biological_process	"Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc]
EOG8B8MSV	GO:0030031	30/98	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG8B8MSV	GO:0005524	21/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8B8MSV	GO:0016887	20/98	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8B8MSV	GO:0030286	19/98	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8B8MSV	GO:0035721	1/98	intraciliary retrograde transport	biological_process	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]
EOG8B8MSV	GO:0042623	1/98	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8B8MSV	GO:0045433	1/98	male courtship behavior, veined wing generated song production	biological_process	"The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
EOG8B8MSV	GO:0031223	1/98	auditory behavior	biological_process	"The behavior of an organism in response to a sound." [GOC:pr, GOC:rc]
EOG8B8MSV	GO:0007628	1/98	adult walking behavior	biological_process	"The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907]
EOG8B8MSV	GO:0008049	1/98	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8B8MSV	GO:0007605	1/98	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8B8MSV	GO:0005868	1/98	cytoplasmic dynein complex	cellular_component	"Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:mah, PMID:12600311]
EOG8B8MSV	GO:0006200	1/98	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8GJ248	GO:0016021	6/24	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JQ6CW	GO:0015031	72/218	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8JQ6CW	GO:0005525	72/218	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8JQ6CW	GO:0007264	72/218	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8JQ6CW	GO:0004767	4/218	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8JQ6CW	GO:0043025	2/218	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8JQ6CW	GO:0005515	1/218	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8JQ6CW	GO:0006897	1/218	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8JQ6CW	GO:0045202	1/218	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG82Z767	GO:0004842	14/67	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG82Z767	GO:0005524	12/67	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82Z767	GO:0031145	12/67	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [PMID:15380083]
EOG82Z767	GO:0010458	12/67	exit from mitosis	biological_process	"The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]
EOG82Z767	GO:0016881	7/67	acid-amino acid ligase activity	molecular_function	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
EOG82Z767	GO:0007476	1/67	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG87SVW1	GO:0003012	1/97	muscle system process	biological_process	"A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio]
EOG8STVM6	GO:0005524	1/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8STVM6	GO:0004222	1/98	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG87SVW9	GO:0004222	1/8	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG87SVW9	GO:0008270	1/8	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG812PK8	GO:0005509	40/112	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG812PK8	GO:0004222	39/112	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG812PK8	GO:0008270	38/112	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG812PK8	GO:0016485	2/112	protein processing	biological_process	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]
EOG812PK8	GO:0008586	2/112	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG812PK8	GO:0010629	2/112	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG812PK8	GO:0030513	1/112	positive regulation of BMP signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators]
EOG812PK8	GO:0007378	1/112	amnioserosa formation	biological_process	"Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift." [ISBN:08795694238]
EOG812PK8	GO:0008045	1/112	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG812PK8	GO:0008293	1/112	torso signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
EOG812PK8	GO:0009880	1/112	embryonic pattern specification	biological_process	"The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
EOG812PK8	GO:0007411	1/112	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG812PK8	GO:0005576	1/112	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG812PK8	GO:0016874	1/112	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG812PK8	GO:0007362	1/112	terminal region determination	biological_process	"Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG812PK8	GO:0006508	1/112	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG812PK8	GO:0007313	1/112	maternal specification of dorsal/ventral axis, oocyte, soma encoded	biological_process	"Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG812PK8	GO:0017015	1/112	regulation of transforming growth factor beta receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah]
EOG812PK8	GO:0007415	1/112	defasciculation of motor neuron axon	biological_process	"Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh]
EOG812PK9	GO:0007254	25/123	JNK cascade	biological_process	"An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974]
EOG812PK9	GO:0005524	25/123	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG812PK9	GO:0004674	25/123	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG812PK9	GO:0031532	25/123	actin cytoskeleton reorganization	biological_process	"A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]
EOG812PK9	GO:0005083	24/123	GTPase regulator activity	molecular_function	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
EOG812PK9	GO:0004697	1/123	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG812PK9	GO:0042656	1/123	JUN kinase kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs)." [GOC:bf]
EOG812PK9	GO:0000185	1/123	activation of MAPKKK activity	biological_process	"Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK)." [PMID:9561267]
EOG812PK9	GO:0016301	1/123	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG812PK9	GO:0006468	1/123	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG812PK9	GO:0001748	1/123	optic lobe placode development	biological_process	"The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833]
EOG812PK9	GO:0004702	1/123	receptor signaling protein serine/threonine kinase activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah]
EOG812PK9	GO:0048477	1/123	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG812PK9	GO:0007097	1/123	nuclear migration	biological_process	"The directed movement of the nucleus." [GOC:ai]
EOG812PK9	GO:0001736	1/123	establishment of planar polarity	biological_process	"Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
EOG812PK9	GO:0005938	1/123	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG812PK9	GO:0046529	1/123	imaginal disc fusion, thorax closure	biological_process	"The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm]
EOG812PK9	GO:0016476	1/123	regulation of embryonic cell shape	biological_process	"Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb]
EOG812PK9	GO:0007391	1/123	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG812PK9	GO:0007411	1/123	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG812PK9	GO:0042655	1/123	activation of JNKKK activity	biological_process	"The initiation of the activity of the inactive enzyme JUN kinase kinase kinase (JNKKK) activity." [GOC:bf]
EOG812PK9	GO:0008594	1/123	photoreceptor cell morphogenesis	biological_process	"The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
EOG812PK9	GO:0046580	1/123	negative regulation of Ras protein signal transduction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
EOG812PK9	GO:0008360	1/123	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG812PK9	GO:0007476	1/123	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG812PK9	GO:0008349	1/123	MAP kinase kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549]
EOG812PK9	GO:0009611	1/123	response to wounding	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators]
EOG8X6FP2	GO:0005615	1/111	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8X6FP2	GO:0035556	1/111	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8X6FP2	GO:0016021	1/111	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X6FP2	GO:0005875	1/111	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8X6FP2	GO:0005787	1/111	signal peptidase complex	cellular_component	"A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509]
EOG8X6FP2	GO:0008233	1/111	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8X6FP2	GO:0006465	1/111	signal peptide processing	biological_process	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]
EOG89GNWH	GO:0005201	51/200	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG89GNWH	GO:0005581	49/200	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG89GNWH	GO:0016787	2/200	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG89GNWH	GO:0005587	2/200	collagen type IV trimer	cellular_component	"A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG89GNWH	GO:0007519	1/200	skeletal muscle tissue development	biological_process	"The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
EOG89GNWH	GO:0000139	1/200	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG89GNWH	GO:0007443	1/200	Malpighian tubule morphogenesis	biological_process	"The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089]
EOG89GNWH	GO:0061327	1/200	anterior Malpighian tubule development	biological_process	"The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG89GNWH	GO:0035848	1/200	oviduct morphogenesis	biological_process	"The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:yaf, http://www.thefreedictionary.com/oviduct]
EOG89GNWH	GO:0005351	1/200	sugar:proton symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]
EOG89GNWH	GO:0005811	1/200	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG89GNWH	GO:0007391	1/200	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG89GNWH	GO:0016021	1/200	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG883GJZ	GO:0016021	1/188	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG883GJZ	GO:0006909	1/188	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG81C9BP	GO:0003824	14/79	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG89GNWC	GO:0007018	21/92	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG89GNWC	GO:0005930	21/92	axoneme	cellular_component	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]
EOG89GNWC	GO:0003777	21/92	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG89GNWC	GO:0030286	19/92	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG89GNWC	GO:0005524	16/92	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG89GNWC	GO:0016887	8/92	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG89GNWC	GO:0003676	1/92	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89GNWC	GO:0000166	1/92	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG89GNWC	GO:0042623	1/92	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG89GNWC	GO:0038032	1/92	termination of G-protein coupled receptor signaling pathway	biological_process	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]
EOG89GNWC	GO:0006200	1/92	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG89GNWC	GO:0005875	1/92	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8CRPDG	GO:0004809	26/89	tRNA (guanine-N2-)-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32]
EOG8CRPDG	GO:0003723	25/89	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CRPDG	GO:0046872	1/89	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CRPDG	GO:0000049	1/89	tRNA binding	molecular_function	"Interacting selectively and non-covalently with transfer RNA." [GOC:ai]
EOG8X6FPD	GO:0020037	75/249	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8X6FPD	GO:0004601	75/249	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG8X6FPD	GO:0006979	74/249	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8X6FPD	GO:0042600	2/249	chorion	cellular_component	"A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
EOG8X6FPD	GO:0042744	1/249	hydrogen peroxide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]
EOG8X6FPD	GO:0008270	1/249	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X6FPD	GO:0022008	1/249	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8X6FPD	GO:0046872	1/249	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8X6FPD	GO:0007306	1/249	eggshell chorion assembly	biological_process	"Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8X6FPD	GO:0005576	1/249	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8X6FPD	GO:0006909	1/249	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8CRPDD	GO:0005234	23/81	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8CRPDD	GO:0004970	22/81	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8CRPDD	GO:0016020	19/81	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CRPDD	GO:0016021	4/81	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CRPDD	GO:0015276	1/81	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8CRPDD	GO:0009593	1/81	detection of chemical stimulus	biological_process	"The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
EOG8CRPDD	GO:0036081	1/81	extracellular ammonia-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
EOG8CRPDD	GO:0034220	1/81	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8JQ6C0	GO:0004197	36/130	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG87SVWR	GO:0043565	2/17	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG87SVWR	GO:0005634	2/17	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87SVWR	GO:0006351	2/17	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG87SVWR	GO:0003700	2/17	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG87SVWR	GO:0008270	2/17	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZGRX4	GO:0003676	2/14	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X6FPM	GO:0005622	3/28	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8X6FPM	GO:0005525	3/28	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8X6FPM	GO:0007264	3/28	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8X6FPM	GO:0008270	3/28	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VHNMT	GO:0044237	1/6	cellular metabolic process	biological_process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
EOG8VHNMT	GO:0003824	1/6	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8VHNMT	GO:0050662	1/6	coenzyme binding	molecular_function	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
EOG8X6FPS	GO:0017187	23/74	peptidyl-glutamic acid carboxylation	biological_process	"The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032]
EOG8X6FPS	GO:0008488	23/74	gamma-glutamyl carboxylase activity	molecular_function	"Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide." [PMID:18374194]
EOG8X6FPS	GO:0018214	1/74	protein carboxylation	biological_process	"The addition of a carboxy group to a protein amino acid." [GOC:ai]
EOG8X6FPQ	GO:0006464	47/145	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG8X6FPQ	GO:0005524	6/145	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X6FPQ	GO:0004835	3/145	tubulin-tyrosine ligase activity	molecular_function	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]
EOG8X6FPQ	GO:0016874	3/145	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG812PKQ	GO:0005524	26/93	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG812PKQ	GO:0008026	26/93	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG812PKQ	GO:0003723	25/93	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG812PKQ	GO:0005634	25/93	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG812PKQ	GO:0003676	1/93	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG812PKQ	GO:0022008	1/93	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG812PKQ	GO:0004386	1/93	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG812PKQ	GO:0008152	1/93	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG812PKR	GO:0005524	25/85	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG812PKR	GO:0004674	23/85	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG812PKR	GO:0004672	2/85	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG812PKR	GO:0016301	1/85	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8X6FPX	GO:0003824	177/787	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8X6FPX	GO:0047077	20/787	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	molecular_function	"Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin." [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN]
EOG8X6FPX	GO:0016874	19/787	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8X6FPX	GO:0004497	7/787	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8X6FPX	GO:0008756	4/787	o-succinylbenzoate-CoA ligase activity	molecular_function	"Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate." [EC:6.2.1.26]
EOG8X6FPX	GO:0004467	2/787	long-chain fatty acid-CoA ligase activity	molecular_function	"Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.3]
EOG8X6FPX	GO:0005524	2/787	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X6FPX	GO:0006637	1/787	acyl-CoA metabolic process	biological_process	"The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732]
EOG8X6FPX	GO:0046627	1/787	negative regulation of insulin receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8X6FPX	GO:0046949	1/787	fatty-acyl-CoA biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732]
EOG8X6FPX	GO:0005777	1/787	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8X6FPX	GO:0019433	1/787	triglyceride catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732]
EOG8X6FPX	GO:0001676	1/787	long-chain fatty acid metabolic process	biological_process	"The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ajp]
EOG8X6FPX	GO:0004321	1/787	fatty-acyl-CoA synthase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86]
EOG8X6FPX	GO:0071616	1/787	acyl-CoA biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [GOC:cjk]
EOG8X6FPX	GO:0016021	1/787	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X6FPX	GO:0042626	1/787	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8X6FPX	GO:0009062	1/787	fatty acid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]
EOG8X6FPX	GO:0016887	1/787	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8X6FPX	GO:0008218	1/787	bioluminescence	biological_process	"The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732]
EOG8X99ZC	GO:0003723	3/23	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8X99ZC	GO:0003964	3/23	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8X99ZC	GO:0003899	3/23	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8X99ZC	GO:0003677	3/23	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X99ZC	GO:0006351	3/23	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8MGVP8	GO:0007275	2/97	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8MGVP8	GO:0016321	1/97	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8MGVP9	GO:0003824	36/109	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG89CSP0	GO:0030170	24/89	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG89CSP0	GO:0019752	21/89	carboxylic acid metabolic process	biological_process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]
EOG89CSP0	GO:0016831	20/89	carboxy-lyase activity	molecular_function	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]
EOG89CSP0	GO:0003824	3/89	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG89CSP0	GO:0004837	1/89	tyrosine decarboxylase activity	molecular_function	"Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25]
EOG8WSZQ9	GO:0005524	30/117	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WSZQ9	GO:0003989	27/117	acetyl-CoA carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2]
EOG8WSZQ9	GO:0006633	27/117	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8WSZQ9	GO:0004075	26/117	biotin carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]
EOG8WSZQ9	GO:0046872	25/117	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WSZQ9	GO:0004658	2/117	propionyl-CoA carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3]
EOG8WSZQ9	GO:0016021	1/117	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WSZQ9	GO:0042626	1/117	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8WSZQ9	GO:0005811	1/117	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8WSZQ9	GO:0005737	1/117	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WSZQ9	GO:0016874	1/117	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8WSZQ9	GO:0000902	1/117	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8FXTQ9	GO:0003677	343/539	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FXTQ9	GO:0000786	343/539	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8FXTQ9	GO:0005634	343/539	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FXTQ9	GO:0006334	343/539	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8FXTQ9	GO:0005811	111/539	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8FXTQ9	GO:0005515	23/539	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8MGVP3	GO:0008270	14/476	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MGVP3	GO:0003676	4/476	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FJBS3	GO:0003676	72/1100	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FJBS3	GO:0003964	71/1100	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8FJBS3	GO:0004523	69/1100	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8FJBS3	GO:0003723	34/1100	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8FJBS3	GO:0008270	8/1100	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FJBS3	GO:0004519	1/1100	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8FJBS3	GO:0004842	1/1100	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG883GJQ	GO:0016788	21/72	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG883GJQ	GO:0003723	19/72	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG883GJQ	GO:0006139	17/72	nucleobase-containing compound metabolic process	biological_process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
EOG883GJQ	GO:0003677	4/72	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG883GJQ	GO:0006281	4/72	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG883GJQ	GO:0003676	2/72	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG883GJQ	GO:0004654	1/72	polyribonucleotide nucleotidyltransferase activity	molecular_function	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.8]
EOG8DZ48V	GO:0003676	59/201	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DZ48V	GO:0008270	5/201	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DZ48V	GO:0016021	2/201	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DZ48W	GO:0017017	24/121	MAP kinase tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]
EOG8DZ48W	GO:0004725	19/121	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8DZ48W	GO:0006470	7/121	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8DZ48W	GO:0008138	2/121	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG8DZ48W	GO:0043409	1/121	negative regulation of MAPK cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]
EOG8DZ48W	GO:0016791	1/121	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG8DZ48W	GO:0002385	1/121	mucosal immune response	biological_process	"An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
EOG8DZ48W	GO:0005737	1/121	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8DZ48W	GO:0042127	1/121	regulation of cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
EOG8DZ48W	GO:0007428	1/121	primary branching, open tracheal system	biological_process	"Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG8DZ48W	GO:0016337	1/121	single organismal cell-cell adhesion	biological_process	"The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb]
EOG8DZ48W	GO:0035160	1/121	maintenance of epithelial integrity, open tracheal system	biological_process	"Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process." [GOC:mtg_sensu, PMID:10694415, PMID:14681183]
EOG8DZ48W	GO:0007474	1/121	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG8DZ48P	GO:0008270	31/95	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DZ48P	GO:0004181	31/95	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG815JV1	GO:0009058	23/90	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG815JV1	GO:0016779	21/90	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG815JV1	GO:0004475	4/90	mannose-1-phosphate guanylyltransferase activity	molecular_function	"Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose." [EC:2.7.7.13, RHEA:15232]
EOG815JV1	GO:0005525	2/90	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG815JV1	GO:0009298	2/90	GDP-mannose biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
EOG815JV1	GO:0016740	1/90	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG815JV6	GO:0016746	2/112	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG815JV6	GO:0008307	1/112	structural constituent of muscle	molecular_function	"The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah]
EOG815JV6	GO:0007507	1/112	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8DZ48D	GO:0004842	26/110	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8DZ48D	GO:0003723	24/110	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8DZ48D	GO:0008270	23/110	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DZ48D	GO:0005634	1/110	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8DZ48D	GO:0045879	1/110	negative regulation of smoothened signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG8DZ48D	GO:0007446	1/110	imaginal disc growth	biological_process	"The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387]
EOG8DZ48D	GO:0030162	1/110	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8DZ48D	GO:0048749	1/110	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8DZ48D	GO:0042787	1/110	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological_process	"The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]
EOG8DZ48D	GO:0007112	1/110	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG8DZ48D	GO:0007444	1/110	imaginal disc development	biological_process	"The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238]
EOG8DZ48D	GO:0007283	1/110	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8DZ48D	GO:0007289	1/110	spermatid nucleus differentiation	biological_process	"The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah]
EOG8DZ48D	GO:0008585	1/110	female gonad development	biological_process	"The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb]
EOG8DZ48D	GO:0005737	1/110	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8DZ48D	GO:0007455	1/110	eye-antennal disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG86Q985	GO:0003677	10/105	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86Q985	GO:0003676	3/105	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG86Q985	GO:0005622	1/105	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG89KJ67	GO:0030246	1/4	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG89KJ67	GO:0016835	1/4	carbon-oxygen lyase activity	molecular_function	"Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-]
EOG89KJ67	GO:0046348	1/4	amino sugar catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [CHEBI:28963, GOC:curators]
EOG89KJ67	GO:0005975	1/4	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8WM78D	GO:0005524	30/106	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WM78D	GO:0004674	27/106	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8WM78D	GO:0020037	20/106	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8WM78D	GO:0004693	2/106	cyclin-dependent protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]
EOG8WM78D	GO:0004672	2/106	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8WM78D	GO:0002009	1/106	morphogenesis of an epithelium	biological_process	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
EOG8WM78D	GO:0007552	1/106	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG8WM78D	GO:0006468	1/106	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8WM78D	GO:0048589	1/106	developmental growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]
EOG8WM78D	GO:0002168	1/106	instar larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8WM78D	GO:0005515	1/106	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8WM78D	GO:0030332	1/106	cyclin binding	molecular_function	"Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai]
EOG8WM78D	GO:0001700	1/106	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8WM78D	GO:0008353	1/106	RNA polymerase II carboxy-terminal domain kinase activity	molecular_function	"Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah]
EOG84J50X	GO:0003676	67/288	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84J50X	GO:0003677	3/288	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84J50X	GO:0005524	1/288	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG84J50X	GO:0016020	1/288	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG84J50X	GO:0001614	1/288	purinergic nucleotide receptor activity	molecular_function	"Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
EOG84J50X	GO:0005216	1/288	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG84J50X	GO:0046872	1/288	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82586J	GO:0005089	29/101	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG82586J	GO:0046928	1/101	regulation of neurotransmitter secretion	biological_process	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
EOG82586J	GO:0035011	1/101	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG82586J	GO:0007480	1/101	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG82586J	GO:0031594	1/101	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG82586J	GO:0016740	1/101	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG82RGN3	GO:0006537	28/124	glutamate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
EOG82RGN3	GO:0051536	24/124	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG82RGN3	GO:0050660	23/124	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG82RGN3	GO:0005506	22/124	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG82RGN3	GO:0010181	22/124	FMN binding	molecular_function	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]
EOG82RGN3	GO:0016040	22/124	glutamate synthase (NADH) activity	molecular_function	"Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH." [EC:1.4.1.14, RHEA:13756]
EOG82RGN3	GO:0015930	5/124	glutamate synthase activity	molecular_function	"Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors." [EC:1.4.-.-]
EOG82RGN3	GO:0016639	2/124	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]
EOG82RGN3	GO:0006807	1/124	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG82RGN3	GO:0017113	1/124	dihydropyrimidine dehydrogenase (NADP+) activity	molecular_function	"Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+." [EC:1.3.1.2]
EOG82RGN3	GO:0004355	1/124	glutamate synthase (NADPH) activity	molecular_function	"Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+." [EC:1.4.1.13, RHEA:15504]
EOG82RGN3	GO:0008152	1/124	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG82RGN2	GO:0005886	30/114	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG82RGN2	GO:0005509	30/114	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG82RGN2	GO:0007156	30/114	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG82RGN2	GO:0016021	29/114	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82RGN2	GO:0004022	2/114	alcohol dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
EOG82RGN2	GO:0005887	1/114	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82RGN2	GO:0030950	1/114	establishment or maintenance of actin cytoskeleton polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures." [GOC:mah]
EOG82RGN2	GO:0004714	1/114	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG82RGN2	GO:0005198	1/114	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG82RGN2	GO:0007295	1/114	growth of a germarium-derived egg chamber	biological_process	"Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG82RGN2	GO:0050829	1/114	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG82RGN2	GO:0048477	1/114	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG82RGN2	GO:0007442	1/114	hindgut morphogenesis	biological_process	"The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
EOG82RGN2	GO:0005925	1/114	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG82RGN2	GO:0016339	1/114	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
EOG82RGN2	GO:0050839	1/114	cell adhesion molecule binding	molecular_function	"Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai]
EOG82RGN2	GO:0007440	1/114	foregut morphogenesis	biological_process	"The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid]
EOG82RGN2	GO:0042247	1/114	establishment of planar polarity of follicular epithelium	biological_process	"Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
EOG82RGN2	GO:0045089	1/114	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG82RGN2	GO:0007431	1/114	salivary gland development	biological_process	"The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044]
EOG82RGN2	GO:0007424	1/114	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG82RGN2	GO:0009925	1/114	basal plasma membrane	cellular_component	"The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG82RGN2	GO:0004872	1/114	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG82RGN2	GO:0045571	1/114	negative regulation of imaginal disc growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators]
EOG82586V	GO:0008168	18/90	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG82586V	GO:0006479	18/90	protein methylation	biological_process	"The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai]
EOG82586V	GO:0005737	5/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82586V	GO:0008276	4/90	protein methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732]
EOG82586V	GO:0008469	3/90	histone-arginine N-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine." [EC:2.1.1.125]
EOG82586V	GO:0046872	2/90	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82586V	GO:0006355	1/90	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82586V	GO:0035242	1/90	protein-arginine omega-N asymmetric methyltransferase activity	molecular_function	"Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues." [PMID:14705965, RESID:AA0068, RESID:AA0069]
EOG82586V	GO:0034969	1/90	histone arginine methylation	biological_process	"The modification of a histone by addition of a methyl group to an arginine residue." [GOC:mah]
EOG82586V	GO:0019919	1/90	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	biological_process	"The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine." [RESID:AA0068, RESID:AA0069]
EOG82586V	GO:0005829	1/90	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8C8B7G	GO:0016021	3/87	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Q87H9	GO:0003676	1/9	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84J50K	GO:0003824	10/53	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG84J50K	GO:0016787	6/53	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG84J50K	GO:0033961	1/53	cis-stilbene-oxide hydrolase activity	molecular_function	"Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9]
EOG815JWG	GO:0046872	1/12	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84J501	GO:0010468	1/82	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG84J501	GO:0000176	1/82	nuclear exosome (RNase complex)	cellular_component	"Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]
EOG84J501	GO:0005737	1/82	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8PVRCJ	GO:0003899	27/96	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8PVRCJ	GO:0003677	27/96	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8PVRCJ	GO:0008270	27/96	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PVRCJ	GO:0006351	26/96	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8PVRCJ	GO:0005634	26/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PVRCJ	GO:0006360	1/96	transcription from RNA polymerase I promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
EOG8PVRCJ	GO:0005736	1/96	DNA-directed RNA polymerase I complex	cellular_component	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8Z0DNX	GO:0007275	2/27	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8Z0DNX	GO:0016021	2/27	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z0DNX	GO:0007154	2/27	cell communication	biological_process	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]
EOG8KD91F	GO:0006207	26/89	'de novo' pyrimidine nucleobase biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]
EOG8KD91F	GO:0004590	26/89	orotidine-5'-phosphate decarboxylase activity	molecular_function	"Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP." [EC:4.1.1.23, RHEA:11599]
EOG8KD91F	GO:0044205	24/89	'de novo' UMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen." [GOC:ecd, GOC:jl]
EOG8KD91F	GO:0004588	23/89	orotate phosphoribosyltransferase activity	molecular_function	"Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10]
EOG8KD91F	GO:0005875	1/89	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8KD91F	GO:0009116	1/89	nucleoside metabolic process	biological_process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]
EOG8KD91F	GO:0006221	1/89	pyrimidine nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
EOG82RGNK	GO:0006355	5/212	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82RGNK	GO:0006200	3/212	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG82RGNK	GO:0007018	3/212	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG82RGNK	GO:0042623	3/212	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG82RGNK	GO:0030286	2/212	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG82RGNK	GO:0005875	2/212	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG82RGNK	GO:0007605	1/212	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8PCD93	GO:0005509	5/22	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8PCD93	GO:0005886	5/22	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8PCD93	GO:0007156	5/22	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8PCD95	GO:0004725	1/4	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG85B3W7	GO:0009058	29/95	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG85B3W7	GO:0003824	24/95	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG85B3W7	GO:0004306	3/95	ethanolamine-phosphate cytidylyltransferase activity	molecular_function	"Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine." [EC:2.7.7.14]
EOG85B3W7	GO:0016779	2/95	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG85B3W7	GO:0042439	1/95	ethanolamine-containing compound metabolic process	biological_process	"The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it." [CHEBI:16000, GOC:mah]
EOG8PP0X7	GO:0045454	15/78	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8WM783	GO:0008270	10/61	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WM783	GO:0003676	1/61	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Z0DNK	GO:0007067	1/65	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8Z0DNK	GO:0007279	1/65	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8Z0DNK	GO:0016319	1/65	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8Z0DNK	GO:0005634	1/65	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WM786	GO:0046872	4/95	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WM786	GO:0005737	1/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WM786	GO:0030030	1/95	cell projection organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG8Q87B6	GO:0003676	81/261	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q87B6	GO:0046872	68/261	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Q87B6	GO:0008270	14/261	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q87B6	GO:0005634	5/261	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Q87B6	GO:0005198	1/261	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8Q87B6	GO:0019953	1/261	sexual reproduction	biological_process	"A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny." [GOC:jl, http://en.wikipedia.org/wiki/Sexual_reproduction, ISBN:0387520546]
EOG8Q87B6	GO:0030141	1/261	secretory granule	cellular_component	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732]
EOG8Q87B6	GO:0005576	1/261	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Z0DND	GO:0016791	5/45	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG8Z0DND	GO:0004725	1/45	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG85B3VB	GO:0030246	19/100	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG85B3VB	GO:0021682	1/100	nerve maturation	biological_process	"A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG85B3VB	GO:0019991	1/100	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG85B3VB	GO:0060857	1/100	establishment of glial blood-brain barrier	biological_process	"Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
EOG85B3VB	GO:0008366	1/100	axon ensheathment	biological_process	"Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437]
EOG85B3VB	GO:0031225	1/100	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG85B3VB	GO:0005886	1/100	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG85B3VB	GO:0005918	1/100	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG85B3VB	GO:0061343	1/100	cell adhesion involved in heart morphogenesis	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
EOG85B3VB	GO:0045197	1/100	establishment or maintenance of epithelial cell apical/basal polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]
EOG8HTC7R	GO:0016491	2/7	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8HTC7R	GO:0016020	1/7	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HTC7R	GO:0003993	1/7	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG8HTC7R	GO:0015128	1/7	gluconate transmembrane transporter activity	molecular_function	"Enables the transfer of gluconate from one side of the membrane to the other. Gluconate is the aldonic acid derived from glucose." [GOC:ai, ISBN:0198506732]
EOG815JVX	GO:0005737	6/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG815JVX	GO:0005509	3/89	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG815JVX	GO:0005085	1/89	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG815JVX	GO:0005700	1/89	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG815JVX	GO:0007095	1/89	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG815JVX	GO:0031573	1/89	intra-S DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression." [GOC:vw]
EOG815JVX	GO:0005634	1/89	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG815JVX	GO:0040018	1/89	positive regulation of multicellular organism growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
EOG815JVX	GO:0043087	1/89	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG815JVX	GO:0071480	1/89	cellular response to gamma radiation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah]
EOG815JVX	GO:0033129	1/89	positive regulation of histone phosphorylation	biological_process	"Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah]
EOG815JVX	GO:0006302	1/89	double-strand break repair	biological_process	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]
EOG815JVX	GO:0045793	1/89	positive regulation of cell size	biological_process	"Any process that increases cell size." [GOC:go_curators]
EOG815JVS	GO:0000166	57/140	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG815JVS	GO:0003676	54/140	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG815JVS	GO:0030529	6/140	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG815JVS	GO:0019013	4/140	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG815JVS	GO:0003729	3/140	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG815JVS	GO:0005703	2/140	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG815JVS	GO:0000381	2/140	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG815JVS	GO:0043565	2/140	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG815JVS	GO:0005634	2/140	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG815JVS	GO:0045727	1/140	positive regulation of translation	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb]
EOG815JVS	GO:0035062	1/140	omega speckle	cellular_component	"A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439]
EOG815JVS	GO:0007286	1/140	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG815JVS	GO:0033119	1/140	negative regulation of RNA splicing	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing." [GOC:mah]
EOG815JVS	GO:0009408	1/140	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG815JVS	GO:0022008	1/140	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG815JVS	GO:0007275	1/140	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG815JVS	GO:0008585	1/140	female gonad development	biological_process	"The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb]
EOG815JVS	GO:0005737	1/140	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG815JVS	GO:0048477	1/140	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG815JVS	GO:0000785	1/140	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG815JVS	GO:0005654	1/140	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG815JVS	GO:0048027	1/140	mRNA 5'-UTR binding	molecular_function	"Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule." [GOC:jid]
EOG815JVS	GO:0007067	1/140	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG815JVS	GO:0036099	1/140	female germ-line stem cell population maintenance	biological_process	"The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart]
EOG815JVS	GO:0042594	1/140	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8ZGRV6	GO:0003964	4/61	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8ZGRV6	GO:0004519	4/61	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8ZGRV6	GO:0008270	2/61	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V71ZN	GO:0005509	2/3	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8ZPH8F	GO:0005089	23/128	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8ZPH8F	GO:0035556	2/128	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8ZPH8F	GO:0004833	1/128	tryptophan 2,3-dioxygenase activity	molecular_function	"Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11]
EOG8ZPH8F	GO:0020037	1/128	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8ZPH8F	GO:0019441	1/128	tryptophan catabolic process to kynurenine	biological_process	"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]
EOG86HJTC	GO:0008270	6/40	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG86HJTC	GO:0003676	6/40	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZPH8C	GO:0006915	24/85	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8ZPH8C	GO:0005622	24/85	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8ZPH8C	GO:0022008	1/85	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8ZPH8C	GO:0042981	1/85	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8ZPH8C	GO:1901215	1/85	negative regulation of neuron death	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]
EOG8T7BHP	GO:0005737	1/53	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8T7BHP	GO:0042826	1/53	histone deacetylase binding	molecular_function	"Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl]
EOG8T7BHP	GO:0010629	1/53	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8T7BHP	GO:0005634	1/53	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZPH8H	GO:0005092	24/88	GDP-dissociation inhibitor activity	molecular_function	"Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah]
EOG8ZPH8H	GO:0008277	24/88	regulation of G-protein coupled receptor protein signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators]
EOG8ZPH8H	GO:0045185	1/88	maintenance of protein location	biological_process	"Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf]
EOG8ZPH8H	GO:0008105	1/88	asymmetric protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma]
EOG8ZPH8H	GO:0045167	1/88	asymmetric protein localization involved in cell fate determination	biological_process	"Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai]
EOG8ZPH8H	GO:0030695	1/88	GTPase regulator activity	molecular_function	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
EOG8ZPH8H	GO:0051294	1/88	establishment of spindle orientation	biological_process	"Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai]
EOG8ZPH8H	GO:0019904	1/88	protein domain specific binding	molecular_function	"Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators]
EOG8ZPH8H	GO:0045175	1/88	basal protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf]
EOG8ZPH8H	GO:0007400	1/88	neuroblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
EOG8ZPH8H	GO:0045177	1/88	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8ZPH8H	GO:0055059	1/88	asymmetric neuroblast division	biological_process	"The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
EOG8ZPH8H	GO:0040001	1/88	establishment of mitotic spindle localization	biological_process	"The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai]
EOG8ZPH8H	GO:0005938	1/88	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8ZPH8H	GO:0008356	1/88	asymmetric cell division	biological_process	"The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
EOG8ZPH8H	GO:0000132	1/88	establishment of mitotic spindle orientation	biological_process	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
EOG8ZPH8H	GO:0045179	1/88	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8ZPH8H	GO:0007405	1/88	neuroblast proliferation	biological_process	"The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart]
EOG8ZPH8H	GO:0005515	1/88	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG86HJTV	GO:0005525	1/4	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG86HJTV	GO:0006184	1/4	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG86HJTV	GO:0016020	1/4	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG86HJTV	GO:0007264	1/4	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8THZ86	GO:0005615	42/107	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8THZ86	GO:0008233	6/107	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8THZ86	GO:0030162	2/107	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8THZ86	GO:0010951	2/107	negative regulation of endopeptidase activity	biological_process	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG8THZ86	GO:0004867	2/107	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG8THZ86	GO:0045861	2/107	negative regulation of proteolysis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
EOG8THZ86	GO:0048526	1/107	imaginal disc-derived wing expansion	biological_process	"The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing." [GOC:mtg_sensu, GOC:rc]
EOG8THZ86	GO:0008270	1/107	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8THZ86	GO:0022416	1/107	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8THZ86	GO:0045751	1/107	negative regulation of Toll signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8THZ86	GO:0005634	1/107	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8THZ86	GO:0005576	1/107	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8THZ86	GO:0016740	1/107	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8BCH23	GO:0005852	26/89	eukaryotic translation initiation factor 3 complex	cellular_component	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]
EOG8BCH23	GO:0003743	26/89	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8BCH23	GO:0016282	25/89	eukaryotic 43S preinitiation complex	cellular_component	"A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049]
EOG8BCH23	GO:0033290	25/89	eukaryotic 48S preinitiation complex	cellular_component	"A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049]
EOG8BCH23	GO:0001731	25/89	formation of translation preinitiation complex	biological_process	"The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd]
EOG8BCH23	GO:0006446	25/89	regulation of translational initiation	biological_process	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG8BCH23	GO:0048812	1/89	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8BCH22	GO:0016758	383/1077	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8BCH22	GO:0030259	14/1077	lipid glycosylation	biological_process	"Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah]
EOG8BCH22	GO:0015020	13/1077	glucuronosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17]
EOG8BCH22	GO:0030246	12/1077	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8BCH22	GO:0016999	11/1077	antibiotic metabolic process	biological_process	"The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2]
EOG8BCH22	GO:0016740	3/1077	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8BCH22	GO:0004181	1/1077	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG8BCH22	GO:0008168	1/1077	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8BCH22	GO:0003851	1/1077	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45]
EOG8BCH22	GO:0008270	1/1077	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BCH22	GO:0003676	1/1077	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BCH22	GO:0002121	1/1077	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8BCH27	GO:0008234	26/100	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8BCH27	GO:0030247	22/100	polysaccharide binding	molecular_function	"Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah]
EOG8BCH27	GO:0005044	22/100	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8BCH27	GO:0006955	22/100	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8BCH27	GO:0050790	11/100	regulation of catalytic activity	biological_process	"Any process that modulates the activity of an enzyme." [GOC:ai]
EOG8BCH27	GO:0004197	11/100	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8BCH27	GO:0035593	1/100	positive regulation of Wnt signaling pathway by establishment of Wnt protein localization to extracellular region	biological_process	"Any process that activates or increases the frequency, rate or extent of the Wnt signaling pathway by the directed movement of a Wnt protein within the extracellular region." [GOC:BHF, PMID:19906850]
EOG8BCH27	GO:0017147	1/100	Wnt-protein binding	molecular_function	"Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]
EOG8BCH27	GO:0005615	1/100	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8BCH27	GO:0030177	1/100	positive regulation of Wnt signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8BCH27	GO:0042600	1/100	chorion	cellular_component	"A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
EOG8V71ZQ	GO:0016787	1/28	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG88D389	GO:0007165	19/141	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG88D389	GO:0007432	1/141	salivary gland boundary specification	biological_process	"Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957]
EOG88D389	GO:0008347	1/141	glial cell migration	biological_process	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
EOG88D389	GO:0050919	1/141	negative chemotaxis	biological_process	"The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete]
EOG88D389	GO:0008045	1/141	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG88D389	GO:0007411	1/141	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG88D389	GO:0005515	1/141	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG88D389	GO:0005043	1/141	netrin receptor activity involved in chemorepulsion	molecular_function	"Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin." [GOC:dph, GOC:signaling]
EOG88D389	GO:0016021	1/141	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SFCN3	GO:0008270	2/28	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SFCN3	GO:0005622	2/28	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8SFCN1	GO:0009089	5/16	lysine biosynthetic process via diaminopimelate	biological_process	"The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators]
EOG8SFCN1	GO:0008840	3/16	4-hydroxy-tetrahydrodipicolinate synthase	molecular_function	"Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O." [EC:4.3.3.7, RHEA:14848]
EOG8SFCN1	GO:0008839	1/16	4-hydroxy-tetrahydrodipicolinate reductase	molecular_function	"Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+." [EC:1.17.1.8]
EOG8SFCN1	GO:0005524	1/16	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SFCN1	GO:0016887	1/16	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8SFCN1	GO:0047200	1/16	tetrahydrodipicolinate N-acetyltransferase activity	molecular_function	"Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H(2)O = L-2-acetamido-6-oxopimelate + CoA." [EC:2.3.1.89, RHEA:13088]
EOG8SFCN1	GO:0005737	1/16	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SFCN1	GO:0003942	1/16	N-acetyl-gamma-glutamyl-phosphate reductase activity	molecular_function	"Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+." [EC:1.2.1.38]
EOG8SFCN1	GO:0051287	1/16	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8SFCN1	GO:0016829	1/16	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8H74TG	GO:0003676	18/252	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8H74TG	GO:0046872	18/252	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8H74TG	GO:0016787	17/252	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8H74TG	GO:0009405	1/252	pathogenesis	biological_process	"The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators]
EOG8H74TG	GO:0004222	1/252	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8H74TG	GO:0005604	1/252	basement membrane	cellular_component	"A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]
EOG8H74TG	GO:0007155	1/252	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8H74TG	GO:0003824	1/252	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8H74TG	GO:0003677	1/252	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8H74TG	GO:0005509	1/252	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8H74TG	GO:0005576	1/252	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8V19DQ	GO:0006915	11/80	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8V19DQ	GO:0003676	10/80	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V19DQ	GO:0005509	1/80	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8V19DQ	GO:0051301	1/80	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8ZKN4S	GO:0046872	1/2	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZKN4S	GO:0003676	1/2	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V19DT	GO:0006457	22/84	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8V19DT	GO:0005524	22/84	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8V19DT	GO:0006950	21/84	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8V19DT	GO:0006979	1/84	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8V19DT	GO:0005811	1/84	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8V19DT	GO:0005739	1/84	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8RNDR8	GO:0046872	17/93	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RNDR8	GO:0003676	3/93	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RNDR8	GO:0005634	3/93	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8K9DWD	GO:0003676	1/8	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SFCNZ	GO:0007297	1/73	ovarian follicle cell migration	biological_process	"The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8SFCNZ	GO:0016324	1/73	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8SFCNZ	GO:0005886	1/73	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8SFCNZ	GO:0007605	1/73	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8SFCNZ	GO:0035324	1/73	female germline ring canal	cellular_component	"An intercellular bridge that connects the germline cells of a female cyst." [PMID:9635420]
EOG8SFCNZ	GO:0007293	1/73	germarium-derived egg chamber formation	biological_process	"Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG88SK85	GO:0006596	40/182	polyamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]
EOG88SK85	GO:0003824	34/182	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG88SK85	GO:0004586	10/182	ornithine decarboxylase activity	molecular_function	"Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine." [EC:4.1.1.17, RHEA:22967]
EOG88SK85	GO:0033387	2/182	putrescine biosynthetic process from ornithine	biological_process	"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46]
EOG88SK85	GO:0009089	1/182	lysine biosynthetic process via diaminopimelate	biological_process	"The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators]
EOG88SK85	GO:0008836	1/182	diaminopimelate decarboxylase activity	molecular_function	"Catalysis of the reaction: meso-2,6-diaminopimelate + H(+) = L-lysine + CO(2)." [EC:4.1.1.20, RHEA:15104]
EOG88D38W	GO:0016788	294/950	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG88D38W	GO:0016042	262/950	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG88D38W	GO:0006629	148/950	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG88D38W	GO:0004806	8/950	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG88D38W	GO:0005615	5/950	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG88D38W	GO:0032504	5/950	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG88D38W	GO:0016298	4/950	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG88D38W	GO:0030246	1/950	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG88D38W	GO:0016787	1/950	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG88D38W	GO:0003676	1/950	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88D38W	GO:0007586	1/950	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG88D38W	GO:0042632	1/950	cholesterol homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]
EOG88D38W	GO:0006886	1/950	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG88D38W	GO:0048812	1/950	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG88D38W	GO:0016192	1/950	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG88D38W	GO:0005576	1/950	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG88D38W	GO:0030132	1/950	clathrin coat of coated pit	cellular_component	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]
EOG88D38W	GO:0030130	1/950	clathrin coat of trans-Golgi network vesicle	cellular_component	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]
EOG88D38W	GO:0005198	1/950	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG88D38W	GO:0031410	1/950	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG88D38W	GO:0070328	1/950	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG88D38W	GO:0004771	1/950	sterol esterase activity	molecular_function	"Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13]
EOG8MPM5D	GO:0006139	22/87	nucleobase-containing compound metabolic process	biological_process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
EOG8MPM5D	GO:0008168	22/87	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8MPM5D	GO:0003676	19/87	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88D38H	GO:0003723	20/98	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG88D38H	GO:0045494	1/98	photoreceptor cell maintenance	biological_process	"Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]
EOG88D38H	GO:0007474	1/98	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG8SFCNG	GO:0005525	27/147	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8SFCNG	GO:0003924	25/147	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8SFCNG	GO:0003743	5/147	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8SFCNG	GO:0004781	1/147	sulfate adenylyltransferase (ATP) activity	molecular_function	"Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4]
EOG8SFCNG	GO:0005737	1/147	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SFCNG	GO:0017151	1/147	DEAD/H-box RNA helicase binding	molecular_function	"Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase." [GOC:jl]
EOG8SFCNG	GO:0006413	1/147	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG89S8NC	GO:0016021	19/58	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89S8NC	GO:0016500	13/58	protein-hormone receptor activity	molecular_function	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]
EOG89S8NC	GO:0004930	6/58	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG89S8NC	GO:0007218	1/58	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG89S8NC	GO:0007186	1/58	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG89S8NC	GO:0008188	1/58	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8BCH2N	GO:0016021	43/114	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BCH2N	GO:0070290	1/114	N-acylphosphatidylethanolamine-specific phospholipase D activity	molecular_function	"Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE)." [GOC:elh, PMID:14634025, PMID:15878693]
EOG8BCH2N	GO:0008270	1/114	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BCH2C	GO:0008199	21/83	ferric iron binding	molecular_function	"Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai]
EOG8BCH2C	GO:0005576	21/83	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8BCH2C	GO:0006826	21/83	iron ion transport	biological_process	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8BCH2C	GO:0006879	21/83	cellular iron ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah]
EOG8T7BH3	GO:0008270	24/103	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8T7BH3	GO:0005680	3/103	anaphase-promoting complex	cellular_component	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]
EOG8T7BH3	GO:0004842	3/103	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8T7BH3	GO:0016874	1/103	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8T7BH3	GO:0016567	1/103	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8T7BH6	GO:0003676	6/35	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8T7BH6	GO:0008270	4/35	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8T7BH6	GO:0005634	4/35	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8T7BH6	GO:0046872	2/35	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZPH87	GO:0005524	26/109	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZPH87	GO:0008026	26/109	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8ZPH87	GO:0003676	26/109	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZPH87	GO:0046872	15/109	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZPH87	GO:0007283	14/109	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8ZPH87	GO:0007126	14/109	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8ZPH87	GO:0005737	14/109	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZPH87	GO:0007275	13/109	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8ZPH87	GO:0031047	13/109	gene silencing by RNA	biological_process	"Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054]
EOG8ZPH87	GO:0048477	11/109	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8ZPH87	GO:0030154	3/109	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8ZPH87	GO:0004386	2/109	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8ZPH87	GO:0006403	1/109	RNA localization	biological_process	"A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai]
EOG8ZPH87	GO:0016246	1/109	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG8ZPH87	GO:0008186	1/109	RNA-dependent ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl]
EOG8ZPH87	GO:0006342	1/109	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG8ZPH87	GO:0009994	1/109	oocyte differentiation	biological_process	"The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu]
EOG8ZPH87	GO:0045451	1/109	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8ZPH87	GO:0009951	1/109	polarity specification of dorsal/ventral axis	biological_process	"Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators]
EOG8ZPH87	GO:0046843	1/109	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8ZPH87	GO:0003724	1/109	RNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah]
EOG8ZPH87	GO:0030423	1/109	targeting of mRNA for destruction involved in RNA interference	biological_process	"The process in which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674]
EOG8ZPH87	GO:0009949	1/109	polarity specification of anterior/posterior axis	biological_process	"Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators]
EOG8ZPH87	GO:0060213	1/109	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	biological_process	"Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]
EOG8ZPH87	GO:0030720	1/109	oocyte localization involved in germarium-derived egg chamber formation	biological_process	"Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356]
EOG8ZPH87	GO:0043186	1/109	P granule	cellular_component	"A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
EOG8ZPH87	GO:0030717	1/109	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG8ZPH87	GO:0007294	1/109	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8ZPH87	GO:0006200	1/109	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8ZPH87	GO:0008298	1/109	intracellular mRNA localization	biological_process	"Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai]
EOG8ZPH87	GO:0007076	1/109	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8ZPH87	GO:0001556	1/109	oocyte maturation	biological_process	"A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, http://ovary.stanford.edu]
EOG8ZPH87	GO:0010529	1/109	negative regulation of transposition	biological_process	"Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]
EOG8ZPH87	GO:0005634	1/109	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZPH87	GO:0007315	1/109	pole plasm assembly	biological_process	"Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8ZPH87	GO:0007317	1/109	regulation of pole plasm oskar mRNA localization	biological_process	"Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb]
EOG8V71Z6	GO:0004806	2/5	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG8V71Z6	GO:0006629	2/5	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8V71Z6	GO:0005576	2/5	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8V71Z5	GO:0003677	25/92	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8V71Z5	GO:0003899	25/92	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8V71Z5	GO:0005634	24/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8V71Z5	GO:0006351	24/92	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8V71Z5	GO:0006360	1/92	transcription from RNA polymerase I promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
EOG8V71Z5	GO:0005736	1/92	DNA-directed RNA polymerase I complex	cellular_component	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG8ZPH88	GO:0004222	11/65	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8ZPH88	GO:0008270	6/65	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZPH88	GO:0008237	2/65	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8ZPH88	GO:0004190	1/65	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG873S5X	GO:0046872	18/76	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG873S5X	GO:0070084	17/76	protein initiator methionine removal	biological_process	"The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein." [GOC:imk, GOC:mah]
EOG873S5X	GO:0070006	17/76	metalloaminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG873S5X	GO:0004177	4/76	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG873S5X	GO:0008235	3/76	metalloexopeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]
EOG8D81N2	GO:0005525	25/86	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8D81N2	GO:0006184	25/86	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8D81N2	GO:0007264	25/86	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8D81N2	GO:0016020	25/86	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8D81N2	GO:0004767	2/86	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG879HQX	GO:0003676	9/28	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG879HQX	GO:0007018	1/28	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG879HQX	GO:0003777	1/28	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG879HQX	GO:0005524	1/28	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WHC0T	GO:0008289	20/102	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG8WHC0T	GO:0033868	2/102	Goodpasture-antigen-binding protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein." [EC:2.7.11.9]
EOG8WHC0T	GO:0097001	1/102	ceramide binding	molecular_function	"Interacting selectively and non-covalently with any ceramide, a class of lipids that is composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes." [CHEBI:17761, GOC:sart]
EOG8WHC0T	GO:0035620	1/102	ceramide transporter activity	molecular_function	"Enables the directed movement of ceramides into, out of or within a cell, or between cells. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:sart, PMID:14685229]
EOG8WHC0T	GO:0006665	1/102	sphingolipid metabolic process	biological_process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]
EOG8WHC0T	GO:0016740	1/102	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8WHC0T	GO:0035627	1/102	ceramide transport	biological_process	"The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:bf, GOC:sart]
EOG8WHC0T	GO:0005794	1/102	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8WHC0T	GO:0005783	1/102	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG873S5W	GO:0004930	3/29	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG873S5W	GO:0016021	3/29	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WHC0J	GO:0006606	22/109	protein import into nucleus	biological_process	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]
EOG8WHC0J	GO:0005643	22/109	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG8WHC0J	GO:0003712	1/109	transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8WHC0J	GO:0031490	1/109	chromatin DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah]
EOG8WHC0J	GO:0007346	1/109	regulation of mitotic cell cycle	biological_process	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8WHC0J	GO:0005652	1/109	nuclear lamina	cellular_component	"The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363]
EOG8WHC0J	GO:0007094	1/109	mitotic spindle assembly checkpoint	biological_process	"A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190]
EOG8WHC0J	GO:0045944	1/109	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8WHC0J	GO:0006338	1/109	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG8WHC0J	GO:0051028	1/109	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8WHC0J	GO:0090235	1/109	regulation of metaphase plate congression	biological_process	"Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8WHC0J	GO:0005719	1/109	nuclear euchromatin	cellular_component	"The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732]
EOG8WHC0J	GO:0090316	1/109	positive regulation of intracellular protein transport	biological_process	"Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]
EOG8WHC0J	GO:0016363	1/109	nuclear matrix	cellular_component	"The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]
EOG8WHC0J	GO:0005515	1/109	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8WHC0J	GO:0005819	1/109	spindle	cellular_component	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
EOG8WHC0J	GO:0008270	1/109	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WHC0J	GO:0051225	1/109	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG8WHC0J	GO:1990047	1/109	spindle matrix	cellular_component	"A proteinaceous, nuclear-derived structure that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner during mitosis." [GOC:ans, PMID:19273613, PMID:22855526]
EOG8WHC0J	GO:0030496	1/109	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG8WHC0J	GO:0005737	1/109	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WHC0J	GO:0072686	1/109	mitotic spindle	cellular_component	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
EOG8WHC0J	GO:0051781	1/109	positive regulation of cell division	biological_process	"Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai]
EOG8WHC0J	GO:0045840	1/109	positive regulation of mitotic nuclear division	biological_process	"Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators]
EOG8WHC0J	GO:0000022	1/109	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8WHC0J	GO:0006351	1/109	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8WHC0J	GO:0034401	1/109	chromatin organization involved in regulation of transcription	biological_process	"Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription." [GOC:curators]
EOG8WHC0J	GO:0034399	1/109	nuclear periphery	cellular_component	"The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah]
EOG8WHC0J	GO:0090267	1/109	positive regulation of mitotic cell cycle spindle assembly checkpoint	biological_process	"Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah, GOC:vw]
EOG8WHC0J	GO:0010965	1/109	regulation of mitotic sister chromatid separation	biological_process	"Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis." [GOC:dph, GOC:tb]
EOG8WHC0J	GO:0000775	1/109	chromosome, centromeric region	cellular_component	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
EOG8WHC0J	GO:0060236	1/109	regulation of mitotic spindle organization	biological_process	"Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8WHC0J	GO:0031965	1/109	nuclear membrane	cellular_component	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
EOG8WHC0J	GO:0009408	1/109	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8WHC0J	GO:0051233	1/109	spindle midzone	cellular_component	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
EOG8WHC0J	GO:0070090	1/109	metaphase plate	cellular_component	"The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division." [GOC:mah]
EOG8WHC0J	GO:0005634	1/109	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WHC0J	GO:0042405	1/109	nuclear inclusion body	cellular_component	"An intranuclear focus at which aggregated proteins have been sequestered." [GOC:jl]
EOG8WHC0J	GO:0007067	1/109	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8WHC0J	GO:0005635	1/109	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG8WHC0J	GO:0004402	1/109	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8WHC0J	GO:1901673	1/109	regulation of mitotic spindle assembly	biological_process	"Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie]
EOG8WHC0J	GO:0006355	1/109	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8WHC0J	GO:0005730	1/109	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8V45PH	GO:0004632	3/91	phosphopantothenate--cysteine ligase activity	molecular_function	"Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5]
EOG8V45PH	GO:0022416	1/91	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8V45PH	GO:0007303	1/91	cytoplasmic transport, nurse cell to oocyte	biological_process	"The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238]
EOG8V45PH	GO:0007297	1/91	ovarian follicle cell migration	biological_process	"The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8V45PH	GO:0070328	1/91	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG8V45PH	GO:0030036	1/91	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8V45PH	GO:0030708	1/91	germarium-derived female germ-line cyst encapsulation	biological_process	"Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336]
EOG8V45PH	GO:0030713	1/91	ovarian follicle cell stalk formation	biological_process	"Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8V45PH	GO:0007476	1/91	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8V45PH	GO:0055091	1/91	phospholipid homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell." [GOC:BHF, GOC:rl]
EOG8V45PH	GO:0015937	1/91	coenzyme A biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
EOG8V45PH	GO:0046843	1/91	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG88WFFT	GO:0048015	30/109	phosphatidylinositol-mediated signaling	biological_process	"A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]
EOG88WFFT	GO:0046854	26/109	phosphatidylinositol phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]
EOG88WFFT	GO:0016773	22/109	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG88WFFT	GO:0016301	21/109	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG88WFFT	GO:0004430	4/109	1-phosphatidylinositol 4-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.67, RHEA:19880]
EOG88WFFT	GO:0004797	1/109	thymidine kinase activity	molecular_function	"Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21]
EOG88WFFT	GO:0005524	1/109	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88WFFT	GO:0005886	1/109	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG88WFFX	GO:0046872	26/115	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG88WFFX	GO:0004222	23/115	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG88WFFX	GO:0005777	1/115	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG88WFFX	GO:0003824	1/115	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG88WFFX	GO:0008340	1/115	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG88WFFX	GO:0016787	1/115	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG88WFFX	GO:0090062	1/115	regulation of trehalose metabolic process	biological_process	"Any process that modulates the frequency, rate or extent of trehalose metabolism, the chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:dph, GOC:tb]
EOG88WFFX	GO:0008237	1/115	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG88WFFX	GO:0050829	1/115	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG88WFFX	GO:0045089	1/115	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG88WFFX	GO:0045926	1/115	negative regulation of growth	biological_process	"Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
EOG88WFFX	GO:0046662	1/115	regulation of oviposition	biological_process	"Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:ai]
EOG8W9MJM	GO:0005853	25/90	eukaryotic translation elongation factor 1 complex	cellular_component	"A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950]
EOG8W9MJM	GO:0003746	25/90	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG8W9MJM	GO:0035071	1/90	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8W9MJM	GO:0006414	1/90	translational elongation	biological_process	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]
EOG8W9MJM	GO:0005634	1/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8W9MJM	GO:0005875	1/90	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8W9MJM	GO:0048102	1/90	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8W9MJM	GO:0004364	1/90	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG8W9MJM	GO:0005737	1/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8W9MJM	GO:0005811	1/90	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8HHRG8	GO:0042254	25/98	ribosome biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
EOG8HHRG8	GO:0005634	25/98	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HHRG8	GO:0005525	6/98	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8HHRG8	GO:0046872	3/98	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HHRG8	GO:0005524	3/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8HHRG8	GO:0003924	3/98	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8HHRG8	GO:0006576	2/98	cellular biogenic amine metabolic process	biological_process	"The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]
EOG8HHRG8	GO:0022008	1/98	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8HHRG8	GO:0004177	1/98	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG8HHRG8	GO:0008235	1/98	metalloexopeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]
EOG8R2692	GO:0003964	5/107	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8R2692	GO:0004519	5/107	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8R2692	GO:0005581	3/107	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8R2692	GO:0016021	1/107	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8R2692	GO:0003723	1/107	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8R2692	GO:0016787	1/107	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8R2692	GO:0003676	1/107	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8R2692	GO:0046872	1/107	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8R2692	GO:0005886	1/107	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8R52HJ	GO:0030246	155/416	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8R52HJ	GO:0005615	3/416	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8R52HJ	GO:0032504	3/416	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8R52HJ	GO:0005534	3/416	galactose binding	molecular_function	"Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [CHEBI:28260, GOC:jl, ISBN:0198506732]
EOG8R52HJ	GO:0046692	2/416	sperm competition	biological_process	"Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514]
EOG8R52HJ	GO:0046008	2/416	regulation of female receptivity, post-mating	biological_process	"Any process that modulates the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators]
EOG8R52HJ	GO:0008104	2/416	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8R52HJ	GO:0008233	2/416	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8R52HJ	GO:0016339	1/416	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
EOG8R52HJ	GO:0016787	1/416	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8R52HJ	GO:0009986	1/416	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8R52HJ	GO:0009166	1/416	nucleotide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]
EOG8R52HJ	GO:0016020	1/416	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8R52HJ	GO:0005515	1/416	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8R52HJ	GO:0005576	1/416	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Q5C57	GO:0007155	30/134	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8Q5C57	GO:0031012	30/134	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8Q5C57	GO:0005198	30/134	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8Q5C57	GO:0005581	24/134	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8Q5C57	GO:0008045	1/134	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8Q5C57	GO:0030246	1/134	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8Q5C57	GO:2001046	1/134	positive regulation of integrin-mediated signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol]
EOG8Q5C57	GO:0071711	1/134	basement membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah]
EOG8Q5C57	GO:0014732	1/134	skeletal muscle atrophy	biological_process	"A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle]
EOG8Q5C57	GO:0007005	1/134	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8Q5C57	GO:0014899	1/134	cardiac muscle atrophy	biological_process	"A process, occurring in the heart, in which a decrease in cell mass and then in heart size occurs due to shrinking of the individual cells. The shrinkage is caused by protein degradation." [GOC:mtg_muscle]
EOG8M67ZB	GO:0030414	21/115	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8M67ZB	GO:0005576	21/115	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8M67ZB	GO:0016787	2/115	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8M67ZB	GO:0016020	1/115	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8M67ZB	GO:0004930	1/115	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG81G5K4	GO:0003700	50/159	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG81G5K4	GO:0005634	43/159	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81G5K4	GO:0043565	31/159	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG81G5K4	GO:0000976	19/159	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG81G5K4	GO:0007275	2/159	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG81G5K4	GO:0007480	1/159	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG81G5K4	GO:0021782	1/159	glial cell development	biological_process	"The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG81G5K4	GO:0048800	1/159	antennal morphogenesis	biological_process	"The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid]
EOG81G5K4	GO:0045944	1/159	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG81G5K4	GO:0035015	1/159	elongation of arista core	biological_process	"The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081]
EOG81G5K4	GO:0005737	1/159	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG81G5K4	GO:0045747	1/159	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG81G5K4	GO:0035218	1/159	leg disc development	biological_process	"Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
EOG81G5K4	GO:0000977	1/159	RNA polymerase II regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
EOG81G5K4	GO:0007399	1/159	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG81G5K4	GO:0007422	1/159	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG81G5K4	GO:0010628	1/159	positive regulation of gene expression	biological_process	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG81G5K4	GO:0022416	1/159	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG81G5K4	GO:0045892	1/159	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG81G5K4	GO:0005515	1/159	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG81G5K4	GO:0043234	1/159	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG81G5K4	GO:0010001	1/159	glial cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]
EOG81G5K4	GO:0001077	1/159	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG81G5K3	GO:0030170	36/119	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG81G5K3	GO:0009058	35/119	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG81G5K3	GO:0003824	24/119	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG81G5K3	GO:0008483	6/119	transaminase activity	molecular_function	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]
EOG81G5K3	GO:0004021	6/119	L-alanine:2-oxoglutarate aminotransferase activity	molecular_function	"Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate." [EC:2.6.1.2, RHEA:19456]
EOG8R52HZ	GO:0042302	1/116	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8V19G8	GO:0048060	1/82	negative gravitaxis	biological_process	"The directed movement of a motile cell or organism away from the source of gravity." [GOC:jid]
EOG8V19G8	GO:0070286	1/82	axonemal dynein complex assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:mah, PMID:19052621]
EOG8V19G8	GO:0035253	1/82	ciliary rootlet	cellular_component	"A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [GOC:cilia, PMID:12427867]
EOG8V19G8	GO:0031514	1/82	motile cilium	cellular_component	"A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998]
EOG8V19G8	GO:0003341	1/82	cilium movement	biological_process	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]
EOG8V19G8	GO:0044297	1/82	cell body	cellular_component	"The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]
EOG8V19G8	GO:0097542	1/82	ciliary tip	cellular_component	"Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction." [GOC:cilia, PMID:23970417]
EOG80KBCX	GO:0008270	25/102	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80KBCX	GO:0007010	23/102	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG80KBCX	GO:0016740	1/102	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG80KBCX	GO:0072499	1/102	photoreceptor cell axon guidance	biological_process	"The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
EOG80KBCX	GO:0007411	1/102	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8PP0XP	GO:0006491	26/165	N-glycan processing	biological_process	"The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198]
EOG8PP0XP	GO:0005509	19/165	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8PP0XP	GO:0032450	2/165	maltose alpha-glucosidase activity	molecular_function	"Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141]
EOG8PP0XP	GO:0016301	1/165	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8PP0XP	GO:0046331	1/165	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8V71WH	GO:0007155	30/104	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8V71WH	GO:0005198	30/104	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8V71WH	GO:0015629	30/104	actin cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
EOG8V71WH	GO:0008092	1/104	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8V71WH	GO:0016342	1/104	catenin complex	cellular_component	"Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323]
EOG8V71WH	GO:0007016	1/104	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG8V71WH	GO:0005737	1/104	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8V71WH	GO:0030720	1/104	oocyte localization involved in germarium-derived egg chamber formation	biological_process	"Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356]
EOG8V71WH	GO:0060323	1/104	head morphogenesis	biological_process	"The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph]
EOG8V71WH	GO:0003779	1/104	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8V71WH	GO:0005886	1/104	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8V71WH	GO:0034332	1/104	adherens junction organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah]
EOG8V71WH	GO:0005914	1/104	spot adherens junction	cellular_component	"A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298]
EOG8V71WH	GO:0005912	1/104	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8V71WH	GO:0007163	1/104	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8V71WH	GO:0005515	1/104	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8V71WH	GO:0005913	1/104	cell-cell adherens junction	cellular_component	"An adherens junction which connects a cell to another cell." [GOC:hb]
EOG8V71WH	GO:0005915	1/104	zonula adherens	cellular_component	"A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208]
EOG8BP3SJ	GO:0000166	34/115	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8BP3SJ	GO:0003676	30/115	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BP3SJ	GO:0003677	2/115	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8BP3SJ	GO:0003729	2/115	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8BP3SJ	GO:0008344	1/115	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG8BP3SJ	GO:0048471	1/115	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8BP3SJ	GO:0007417	1/115	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8BP3SJ	GO:0048812	1/115	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8BP3SJ	GO:0045886	1/115	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8BP3SJ	GO:0030529	1/115	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8BP3SJ	GO:0007628	1/115	adult walking behavior	biological_process	"The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907]
EOG8BP3SJ	GO:0008345	1/115	larval locomotory behavior	biological_process	"Locomotory behavior in a larval (immature) organism." [GOC:ai]
EOG8BP3SJ	GO:0007528	1/115	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8BP3SJ	GO:0007274	1/115	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8BP3SJ	GO:0005634	1/115	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BP3SJ	GO:0019013	1/115	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG80KBCQ	GO:0004222	30/98	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8HHRGR	GO:0016787	6/173	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8HHRGR	GO:0052689	2/173	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG8HHRGR	GO:0016298	2/173	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG8HHRGR	GO:0006629	2/173	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8HHRGR	GO:0035220	1/173	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8HHRGR	GO:0022416	1/173	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8HHRGR	GO:0016021	1/173	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Q5C5Q	GO:0042302	30/139	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8Q5C5Q	GO:0005581	1/139	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8Q5C5R	GO:0003676	1/30	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q5C5R	GO:0004523	1/30	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8HHRGV	GO:0005525	23/89	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8HHRGV	GO:0007275	1/89	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8HHRGV	GO:0040018	1/89	positive regulation of multicellular organism growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8HHRGV	GO:0006184	1/89	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8HHRGV	GO:0046626	1/89	regulation of insulin receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8HHRGV	GO:0005737	1/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HHRGV	GO:0042254	1/89	ribosome biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
EOG8HHRGV	GO:0005783	1/89	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8HHRGV	GO:0051168	1/89	nuclear export	biological_process	"The directed movement of substances out of the nucleus." [GOC:ai]
EOG8HHRGV	GO:0015030	1/89	Cajal body	cellular_component	"A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]
EOG8HHRGV	GO:0003924	1/89	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8HHRGV	GO:0015031	1/89	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8HHRGV	GO:0030307	1/89	positive regulation of cell growth	biological_process	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8PP0XG	GO:0005634	8/57	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PP0XG	GO:0043565	8/57	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8PP0XG	GO:0003700	8/57	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8R52H4	GO:0007155	3/85	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8R52H4	GO:0005737	1/85	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8R52H4	GO:0001952	1/85	regulation of cell-matrix adhesion	biological_process	"Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]
EOG8R52H7	GO:0005085	1/5	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8R52H7	GO:0007264	1/5	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8HHRGB	GO:0007018	1/126	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8HHRGB	GO:0006200	1/126	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8HHRGB	GO:0042623	1/126	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8HHRGB	GO:0030286	1/126	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8JMB5V	GO:0003676	8/79	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JMB5V	GO:0008270	8/79	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8JMB5V	GO:0035091	1/79	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG8HHRGD	GO:0004222	28/95	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8V45P9	GO:0008270	19/71	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V45P9	GO:0005634	1/71	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8V45P9	GO:0005487	1/71	nucleocytoplasmic transporter activity	molecular_function	"Enables the directed movement of substances between the nucleus and the cytoplasm of a cell." [GOC:ai]
EOG8V45P9	GO:0006607	1/71	NLS-bearing protein import into nucleus	biological_process	"The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai]
EOG8V45P9	GO:0044613	1/71	nuclear pore central transport channel	cellular_component	"The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
EOG8V45P9	GO:0017056	1/71	structural constituent of nuclear pore	molecular_function	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex." [GOC:mah]
EOG8V45P9	GO:0005635	1/71	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG8V45P9	GO:0005813	1/71	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8V45P9	GO:0006351	1/71	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8V45P9	GO:0034399	1/71	nuclear periphery	cellular_component	"The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah]
EOG8V45P9	GO:0034401	1/71	chromatin organization involved in regulation of transcription	biological_process	"Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription." [GOC:curators]
EOG8V45P9	GO:0007184	1/71	SMAD protein import into nucleus	biological_process	"The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph]
EOG8V45P9	GO:0006606	1/71	protein import into nucleus	biological_process	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]
EOG8V45P9	GO:0072686	1/71	mitotic spindle	cellular_component	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
EOG8V45P9	GO:0031490	1/71	chromatin DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah]
EOG8V45P9	GO:0051298	1/71	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8V45P9	GO:0051028	1/71	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8V45P9	GO:0006999	1/71	nuclear pore organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore." [GOC:dph, GOC:jid, GOC:jl, GOC:mah]
EOG8V45P9	GO:0005719	1/71	nuclear euchromatin	cellular_component	"The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732]
EOG8V45P9	GO:0022008	1/71	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8V45P9	GO:0045944	1/71	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8V45P9	GO:0031965	1/71	nuclear membrane	cellular_component	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
EOG8V45P9	GO:0006338	1/71	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG866Z0T	GO:0016021	25/105	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG866Z0T	GO:0005524	24/105	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG866Z0T	GO:0046872	23/105	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG866Z0T	GO:0005388	21/105	calcium-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8]
EOG866Z0T	GO:0019829	4/105	cation-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]
EOG866Z0T	GO:0071421	1/105	manganese ion transmembrane transport	biological_process	"A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG866Z0T	GO:0019722	1/105	calcium-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]
EOG866Z0T	GO:0005794	1/105	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG866Z0T	GO:0005783	1/105	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG866Z0T	GO:0005777	1/105	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG866Z0T	GO:0070588	1/105	calcium ion transmembrane transport	biological_process	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG866Z0T	GO:0015410	1/105	manganese-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)." [EC:3.6.3.35]
EOG866Z0T	GO:0042044	1/105	fluid transport	biological_process	"The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG866Z0T	GO:0051208	1/105	sequestering of calcium ion	biological_process	"The process of binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]
EOG866Z0T	GO:0006816	1/105	calcium ion transport	biological_process	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8KD916	GO:0019028	6/25	viral capsid	cellular_component	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
EOG8KD916	GO:0005198	6/25	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8KD916	GO:0005524	1/25	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KD916	GO:0006298	1/25	mismatch repair	biological_process	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
EOG8KD916	GO:0030983	1/25	mismatched DNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]
EOG8PG8GV	GO:0005741	21/90	mitochondrial outer membrane	cellular_component	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
EOG8PG8GV	GO:0006886	21/90	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8PG8GV	GO:0005739	1/90	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8PG8GV	GO:0015450	1/90	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	molecular_function	"Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729]
EOG8PG8GV	GO:0071806	1/90	protein transmembrane transport	biological_process	"The directed movement of a protein across a membrane by means of some agent such as a transporter or pore." [GOC:mah, GOC:vw]
EOG8PG8GV	GO:0005742	1/90	mitochondrial outer membrane translocase complex	cellular_component	"A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629]
EOG873S52	GO:0050660	110/344	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG873S52	GO:0009055	107/344	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG873S52	GO:0051537	105/344	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG873S52	GO:0016614	104/344	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG873S52	GO:0005506	90/344	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG873S52	GO:0046872	23/344	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG873S52	GO:0016491	9/344	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG873S52	GO:0008762	6/344	UDP-N-acetylmuramate dehydrogenase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158]
EOG873S52	GO:0051536	2/344	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG873S52	GO:0018492	1/344	carbon-monoxide dehydrogenase (acceptor) activity	molecular_function	"Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.99.2]
EOG873S52	GO:0007155	1/344	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG873S52	GO:0016020	1/344	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG873S54	GO:0005524	27/86	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG873S54	GO:0016021	27/86	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG873S54	GO:0042626	26/86	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG873S54	GO:0032440	2/86	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG873S54	GO:0008559	1/86	xenobiotic-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44]
EOG8V45P7	GO:2000601	28/98	positive regulation of Arp2/3 complex-mediated actin nucleation	biological_process	"Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation." [PMID:21454476]
EOG8V45P7	GO:0007015	27/98	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8V45P7	GO:0034314	1/98	Arp2/3 complex-mediated actin nucleation	biological_process	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]
EOG8V45P7	GO:0016203	1/98	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8V45P7	GO:0008407	1/98	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG8V45P7	GO:0007286	1/98	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG8V45P7	GO:0006886	1/98	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8V45P7	GO:0045886	1/98	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8V45P7	GO:0007409	1/98	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8V45P7	GO:0005737	1/98	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8V45P7	GO:0016476	1/98	regulation of embryonic cell shape	biological_process	"Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb]
EOG8V45P7	GO:0030833	1/98	regulation of actin filament polymerization	biological_process	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG8V45P7	GO:0009913	1/98	epidermal cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]
EOG8V45P7	GO:0006900	1/98	membrane budding	biological_process	"The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]
EOG8V45P7	GO:0007423	1/98	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8V45P7	GO:0035212	1/98	cell competition in a multicellular organism	biological_process	"Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286]
EOG8V45P7	GO:0072583	1/98	clathrin-mediated endocytosis	biological_process	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]
EOG8V45P7	GO:0003779	1/98	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8V45P7	GO:0008582	1/98	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8V45P7	GO:0007413	1/98	axonal fasciculation	biological_process	"The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh]
EOG8V45P7	GO:0001578	1/98	microtubule bundle formation	biological_process	"A process that results in a parallel arrangement of microtubules." [GOC:dph]
EOG8V45P7	GO:0045165	1/98	cell fate commitment	biological_process	"The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
EOG8V45P7	GO:0035017	1/98	cuticle pattern formation	biological_process	"The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf]
EOG8V45P7	GO:0003383	1/98	apical constriction	biological_process	"The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8V45P7	GO:0016028	1/98	rhabdomere	cellular_component	"The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774]
EOG8V45P7	GO:0007520	1/98	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG8V45P7	GO:0005199	1/98	structural constituent of cell wall	molecular_function	"The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah]
EOG8V45P7	GO:0005902	1/98	microvillus	cellular_component	"Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194]
EOG8V45P7	GO:0008356	1/98	asymmetric cell division	biological_process	"The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
EOG8V45P7	GO:0005515	1/98	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8V45P7	GO:0005634	1/98	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D81NB	GO:0003677	4/41	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8D81NB	GO:0003676	1/41	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG86Q97P	GO:0016021	129/334	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86Q97P	GO:0004672	1/334	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG86Q97P	GO:0005524	1/334	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG86Q97P	GO:0045169	1/334	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG8NZX73	GO:0016021	1/88	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NZX73	GO:0004721	1/88	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8NZX77	GO:0015074	206/1674	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8NZX77	GO:0003964	173/1674	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8NZX77	GO:0003723	170/1674	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8NZX77	GO:0003676	151/1674	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NZX77	GO:0008270	67/1674	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NZX77	GO:0004190	64/1674	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8NZX77	GO:0004523	2/1674	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8NZX77	GO:0003677	2/1674	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NZX77	GO:0003899	1/1674	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8NZX77	GO:0043565	1/1674	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NZX77	GO:0005634	1/1674	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NZX77	GO:0003700	1/1674	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NZX77	GO:0004519	1/1674	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8NZX77	GO:0046872	1/1674	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NZX77	GO:0019048	1/1674	modulation by virus of host morphology or physiology	biological_process	"The process in which a virus effects a change in the structure or processes of its host organism." [GOC:bf, GOC:jl, ISBN:0781718325, UniProtKB-KW:KW-0945]
EOG8NZX77	GO:0019031	1/1674	viral envelope	cellular_component	"The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope]
EOG8NZX77	GO:0006351	1/1674	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8NZX77	GO:0008233	1/1674	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG880MC3	GO:0016021	24/89	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG880MC0	GO:0004735	55/191	pyrroline-5-carboxylate reductase activity	molecular_function	"Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2]
EOG880MC0	GO:0055129	40/191	L-proline biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:ecd]
EOG880MC0	GO:0006561	15/191	proline biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732]
EOG8NS5R9	GO:0016021	33/146	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NS5R9	GO:0046872	33/146	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NS5R9	GO:0005524	31/146	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8NS5R9	GO:0019829	30/146	cation-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]
EOG8NS5R9	GO:0005388	2/146	calcium-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8]
EOG8NS5R9	GO:0000166	2/146	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8NS5R9	GO:0016887	1/146	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8NS5R9	GO:0006812	1/146	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8NS5R9	GO:0004721	1/146	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG88WFH8	GO:0016020	1/15	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG88WFH8	GO:0055085	1/15	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG88WFH8	GO:0005215	1/15	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8SXQT2	GO:0045892	28/104	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8SXQT2	GO:0005634	28/104	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SXQT2	GO:0007626	1/104	locomotory behavior	biological_process	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
EOG8SXQT2	GO:0003712	1/104	transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8SXQT2	GO:0006351	1/104	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8SXQT2	GO:0035222	1/104	wing disc pattern formation	biological_process	"The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf]
EOG8SXQT2	GO:0048666	1/104	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8SXQT2	GO:0014019	1/104	neuroblast development	biological_process	"The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585]
EOG8SXQT2	GO:0008283	1/104	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8SXQT5	GO:0016021	1/110	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86Q97K	GO:0016740	1/8	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG86Q97K	GO:0009349	1/8	riboflavin synthase complex	cellular_component	"An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." [EC:2.5.1.9]
EOG86Q97K	GO:0009231	1/8	riboflavin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
EOG818F2V	GO:0003712	24/96	transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG818F2V	GO:0000124	24/96	SAGA complex	cellular_component	"A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012]
EOG818F2V	GO:0070461	1/96	SAGA-type complex	cellular_component	"A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [GOC:mah, PMID:10637607, PMID:17337012]
EOG818F2V	GO:0005634	1/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG866Z0X	GO:0005214	1/54	structural constituent of chitin-based cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG866Z0X	GO:0016476	1/54	regulation of embryonic cell shape	biological_process	"Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb]
EOG866Z0X	GO:0007160	1/54	cell-matrix adhesion	biological_process	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]
EOG866Z0X	GO:0016324	1/54	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG866Z0X	GO:0003383	1/54	apical constriction	biological_process	"The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG866Z0X	GO:0007015	1/54	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8XSP46	GO:0005634	29/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XSP46	GO:0006355	29/95	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8XSP46	GO:0016747	26/95	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8XSP46	GO:0004402	3/95	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8XSP46	GO:0006351	1/95	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8XSP46	GO:0046872	1/95	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XSP46	GO:0005705	1/95	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG8XSP46	GO:0043524	1/95	negative regulation of neuron apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
EOG8XSP46	GO:0043967	1/95	histone H4 acetylation	biological_process	"The modification of histone H4 by the addition of an acetyl group." [GOC:jl]
EOG8XSP46	GO:2000331	1/95	regulation of terminal button organization	biological_process	"Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah]
EOG8XSP46	GO:0016573	1/95	histone acetylation	biological_process	"The modification of a histone by the addition of an acetyl group." [GOC:ai]
EOG8XSP46	GO:0006974	1/95	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8XSP46	GO:0010468	1/95	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8XSP46	GO:0043486	1/95	histone exchange	biological_process	"The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]
EOG8XSP46	GO:0007399	1/95	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8XSP46	GO:0035267	1/95	NuA4 histone acetyltransferase complex	cellular_component	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]
EOG8XSP46	GO:0000123	1/95	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG8XSP46	GO:0048167	1/95	regulation of synaptic plasticity	biological_process	"A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290]
EOG818F2N	GO:0003682	1/22	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8Q87BM	GO:0016021	19/88	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Q87BM	GO:0022857	16/88	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8Q87BM	GO:0055085	3/88	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8Q87BM	GO:0008643	2/88	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG818F27	GO:0046872	6/74	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG818F26	GO:0016192	3/100	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG818F26	GO:0006886	3/100	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG818F26	GO:0042384	1/100	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG818F26	GO:0016746	1/100	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG818F26	GO:0006506	1/100	GPI anchor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
EOG818F26	GO:0003840	1/100	gamma-glutamyltransferase activity	molecular_function	"Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2]
EOG818F26	GO:0031513	1/100	nonmotile primary cilium	cellular_component	"A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998]
EOG818F26	GO:0006749	1/100	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG818F26	GO:0016021	1/100	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG818F26	GO:0016491	1/100	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG818F26	GO:0022008	1/100	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG818F26	GO:0005789	1/100	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG818F26	GO:0035058	1/100	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG818F25	GO:0016021	27/74	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG818F25	GO:0005509	23/74	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG818F25	GO:0016787	1/74	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG818F24	GO:0005525	26/123	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG818F24	GO:0007264	26/123	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG818F24	GO:0005524	26/123	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG818F24	GO:0005622	25/123	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG818F24	GO:0004674	24/123	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG818F24	GO:0004672	3/123	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG818F24	GO:0050808	1/123	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG818F24	GO:0032418	1/123	lysosome localization	biological_process	"Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]
EOG818F24	GO:1900242	1/123	regulation of synaptic vesicle endocytosis	biological_process	"Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie]
EOG818F24	GO:0018105	1/123	peptidyl-serine phosphorylation	biological_process	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]
EOG818F24	GO:0005737	1/123	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG818F24	GO:0090128	1/123	regulation of synapse maturation	biological_process	"Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG818F24	GO:0070507	1/123	regulation of microtubule cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG818F24	GO:2000331	1/123	regulation of terminal button organization	biological_process	"Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah]
EOG818F24	GO:0017137	1/123	Rab GTPase binding	molecular_function	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG818F24	GO:0016301	1/123	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG818F24	GO:0005515	1/123	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG818F24	GO:0031902	1/123	late endosome membrane	cellular_component	"The lipid bilayer surrounding a late endosome." [GOC:pz]
EOG818F24	GO:0005765	1/123	lysosomal membrane	cellular_component	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]
EOG818F24	GO:0007528	1/123	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG818F24	GO:0048312	1/123	intracellular distribution of mitochondria	biological_process	"Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid]
EOG818F24	GO:0031594	1/123	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8W10WB	GO:0005737	10/52	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8W10WB	GO:0008276	10/52	protein methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732]
EOG8C2KQG	GO:0005524	2/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8DV83N	GO:0004930	2/13	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8DV83N	GO:0016021	2/13	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D293R	GO:0043066	1/93	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8D293R	GO:0005515	1/93	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8D293R	GO:0005634	1/93	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D293R	GO:0005576	1/93	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8D293R	GO:0022008	1/93	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8D293R	GO:0006915	1/93	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8D293R	GO:0006955	1/93	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8T1M46	GO:0016021	1/16	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8T1M46	GO:0004930	1/16	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG82Z774	GO:0048047	1/66	mating behavior, sex discrimination	biological_process	"The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700]
EOG82Z774	GO:0005179	1/66	hormone activity	molecular_function	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]
EOG82Z774	GO:0048018	1/66	receptor agonist activity	molecular_function	"Interacts with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb, ISBN:0198506732]
EOG82Z774	GO:0005615	1/66	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG82Z774	GO:0007218	1/66	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG82Z774	GO:0007621	1/66	negative regulation of female receptivity	biological_process	"Any process that stops, prevents or reduces the receptiveness of a female to male advances." [GOC:bf, PMID:11092827]
EOG82Z774	GO:0071855	1/66	neuropeptide receptor binding	molecular_function	"Interacting selectively and non-covalently with a neuropeptide receptor." [GOC:kmv, GOC:mah]
EOG82Z774	GO:0005184	1/66	neuropeptide hormone activity	molecular_function	"The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]
EOG86Q976	GO:0003700	74/252	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG86Q976	GO:0005634	74/252	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86Q976	GO:0043565	73/252	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG86Q976	GO:0001745	2/252	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG86Q976	GO:0048749	2/252	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG86Q976	GO:0045944	1/252	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG86Q976	GO:0007455	1/252	eye-antennal disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG86Q976	GO:0001744	1/252	optic lobe placode formation	biological_process	"Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833]
EOG86Q976	GO:0007623	1/252	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG86Q976	GO:0000976	1/252	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG86Q976	GO:0008406	1/252	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG86Q976	GO:0007503	1/252	fat body development	biological_process	"The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089]
EOG86Q976	GO:0048812	1/252	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG86Q976	GO:0007283	1/252	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG86Q976	GO:0001751	1/252	compound eye photoreceptor cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
EOG86Q976	GO:0001746	1/252	Bolwig's organ morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380]
EOG86Q976	GO:0008347	1/252	glial cell migration	biological_process	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
EOG86Q976	GO:0009649	1/252	entrainment of circadian clock	biological_process	"The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid]
EOG86Q976	GO:0006366	1/252	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG86Q976	GO:0003705	1/252	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG86Q976	GO:0007520	1/252	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG86Q976	GO:0035271	1/252	ring gland development	biological_process	"Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones." [GOC:bf, PMID:11223816, PMID:9584098]
EOG86Q976	GO:0007458	1/252	progression of morphogenetic furrow involved in compound eye morphogenesis	biological_process	"The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883]
EOG86Q976	GO:0008134	1/252	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG86Q976	GO:0007498	1/252	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG86Q976	GO:0048813	1/252	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG86Q976	GO:0005515	1/252	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8WQ3GN	GO:0004842	1/86	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8WQ3GN	GO:0051438	1/86	regulation of ubiquitin-protein transferase activity	biological_process	"Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb]
EOG86Q974	GO:0016021	45/122	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86Q974	GO:0004930	38/122	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG86Q974	GO:0004983	8/122	neuropeptide Y receptor activity	molecular_function	"Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
EOG86Q974	GO:0050254	4/122	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG86Q974	GO:0008188	2/122	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG86Q974	GO:0007186	2/122	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG86Q974	GO:0005887	2/122	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86Q974	GO:0007218	2/122	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG86Q974	GO:0008261	2/122	allatostatin receptor activity	molecular_function	"Combining with allatostatin to initiate a change in cell activity." [GOC:ai]
EOG86Q974	GO:0005840	1/122	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8NS5RR	GO:0005975	1/82	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8NS5RR	GO:0004553	1/82	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8NS5RR	GO:0005875	1/82	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8NS5RR	GO:0008017	1/82	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8NS5RR	GO:0007017	1/82	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8XWJDD	GO:0016021	70/167	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SXQTF	GO:0016020	31/102	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8SXQTF	GO:0016628	4/102	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG8SXQTF	GO:0047598	3/102	7-dehydrocholesterol reductase activity	molecular_function	"Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+." [EC:1.3.1.21]
EOG8SXQTF	GO:0003677	2/102	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8SXQTF	GO:0006351	1/102	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8SXQTF	GO:0046907	1/102	intracellular transport	biological_process	"The directed movement of substances within a cell." [GOC:ai]
EOG8SXQTF	GO:0050613	1/102	delta14-sterol reductase activity	molecular_function	"Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol." [EC:1.3.1.70, MetaCyc:1.3.1.70-RXN]
EOG8SXQTF	GO:0005637	1/102	nuclear inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma]
EOG8SXQTF	GO:0005639	1/102	integral component of nuclear inner membrane	cellular_component	"The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]
EOG8SXQTF	GO:0005634	1/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SXQTF	GO:0003682	1/102	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8SXQTF	GO:0003700	1/102	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8SXQTF	GO:0006997	1/102	nucleus organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
EOG8SXQTF	GO:0043565	1/102	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8SXQTF	GO:0005635	1/102	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG8SXQTF	GO:0005521	1/102	lamin binding	molecular_function	"Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732]
EOG898XKR	GO:0003677	1/2	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NZX7W	GO:0003676	8/36	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NZX7W	GO:0016307	1/36	phosphatidylinositol phosphate kinase activity	molecular_function	"Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495]
EOG8NZX7W	GO:0003723	1/36	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8NZX7W	GO:0003964	1/36	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8GJ255	GO:0033897	31/97	ribonuclease T2 activity	molecular_function	"Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.1]
EOG8GJ255	GO:0003723	31/97	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8GJ255	GO:0032504	1/97	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8GJ255	GO:0090501	1/97	RNA phosphodiester bond hydrolysis	biological_process	"The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
EOG8GJ255	GO:0006401	1/97	RNA catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]
EOG8GJ255	GO:0004540	1/97	ribonuclease activity	molecular_function	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]
EOG8GJ255	GO:0005615	1/97	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8NS5RG	GO:0004503	2/265	monophenol monooxygenase activity	molecular_function	"Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1, GOC:bf, GOC:sart, PMID:4965136]
EOG8NS5RG	GO:0008045	1/265	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8NS5RG	GO:0016201	1/265	synaptic target inhibition	biological_process	"The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]
EOG8NS5RG	GO:0005811	1/265	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8NS5RG	GO:0046872	1/265	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NS5RG	GO:0005616	1/265	larval serum protein complex	cellular_component	"A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, PMID:6781759]
EOG8NS5RG	GO:0045735	1/265	nutrient reservoir activity	molecular_function	"Functions in the storage of nutritious substrates." [GOC:ai]
EOG8NS5RG	GO:0016491	1/265	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8ZSCHX	GO:0004222	52/114	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8ZSCHX	GO:0016020	52/114	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8ZSCHX	GO:0007283	2/114	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8XWJDW	GO:0003677	15/33	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NZX7B	GO:0005524	29/94	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8NZX7B	GO:0016887	27/94	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8NZX7B	GO:0015408	1/94	ferric-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [EC:3.6.3.30]
EOG8NZX7B	GO:0015416	1/94	organic phosphonate transmembrane-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:3.6.3.28]
EOG89KJ7B	GO:0004129	35/91	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG89KJ7B	GO:0016887	1/91	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG89KJ7B	GO:0005524	1/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WQ3GQ	GO:0004619	4/17	phosphoglycerate mutase activity	molecular_function	"Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1]
EOG8WQ3GQ	GO:0030145	4/17	manganese ion binding	molecular_function	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
EOG8WQ3GQ	GO:0006007	4/17	glucose catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai]
EOG8WQ3GQ	GO:0005737	4/17	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WQ3GR	GO:0005634	25/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WQ3GR	GO:0006470	25/84	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8WQ3GR	GO:0005737	25/84	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WQ3GR	GO:0004721	24/84	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8WQ3GR	GO:0046872	23/84	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WQ3GR	GO:0004722	1/84	protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
EOG8WQ3GR	GO:0000278	1/84	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8WQ3GS	GO:0004348	80/206	glucosylceramidase activity	molecular_function	"Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45]
EOG8WQ3GS	GO:0005975	80/206	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8WQ3GS	GO:0006665	80/206	sphingolipid metabolic process	biological_process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]
EOG8WQ3GS	GO:0034620	2/206	cellular response to unfolded protein	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah]
EOG8WQ3GS	GO:0008234	1/206	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8HHRGC	GO:0007218	8/22	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8HHRGC	GO:0016021	6/22	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HHRGC	GO:0016020	2/22	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HHRGC	GO:0005509	2/22	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8HHRGC	GO:0005886	1/22	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8QC3KQ	GO:0007476	1/106	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8QC3KQ	GO:0035147	1/106	branch fusion, open tracheal system	biological_process	"Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584]
EOG8QC3KQ	GO:0022008	1/106	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8QC3KQ	GO:0016246	1/106	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG8QC3KQ	GO:0002165	1/106	instar larval or pupal development	biological_process	"The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
EOG8QC3KQ	GO:0005515	1/106	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QC3KQ	GO:0048675	1/106	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG8QC3KQ	GO:0035155	1/106	negative regulation of terminal cell fate specification, open tracheal system	biological_process	"Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [GOC:mtg_sensu, PMID:10684581]
EOG8QC3KQ	GO:0007430	1/106	terminal branching, open tracheal system	biological_process	"Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG8QC3KQ	GO:0005737	1/106	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8QC3KR	GO:0050661	26/94	NADP binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]
EOG8QC3KR	GO:0006098	26/94	pentose-phosphate shunt	biological_process	"The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]
EOG8QC3KR	GO:0004616	26/94	phosphogluconate dehydrogenase (decarboxylating) activity	molecular_function	"Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44]
EOG8QC3KR	GO:0019521	2/94	D-gluconate metabolic process	biological_process	"The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732]
EOG851H7K	GO:0008270	31/275	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG851H7K	GO:0003676	5/275	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG851H7K	GO:0003677	2/275	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG851H7K	GO:0016021	1/275	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG851H7K	GO:0015074	1/275	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG851H7K	GO:0005634	1/275	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG851H7K	GO:0004803	1/275	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG851H7K	GO:0004518	1/275	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG851H7K	GO:0055085	1/275	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG851H7K	GO:0006313	1/275	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG88PQ0M	GO:0035556	24/111	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG88PQ0M	GO:0046872	24/111	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG88PQ0M	GO:0005089	23/111	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG88PQ0M	GO:0016477	1/111	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG88PQ0M	GO:0016740	1/111	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG88PQ0M	GO:0004697	1/111	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG88PQ0M	GO:0072499	1/111	photoreceptor cell axon guidance	biological_process	"The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
EOG88PQ0M	GO:0007015	1/111	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG88PQ0M	GO:0032314	1/111	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG88PQ0M	GO:0007520	1/111	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG88PQ0M	GO:0007391	1/111	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG88PQ0M	GO:0007411	1/111	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG88PQ0M	GO:0007417	1/111	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG88PQ0M	GO:0031532	1/111	actin cytoskeleton reorganization	biological_process	"A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]
EOG88PQ0M	GO:0032863	1/111	activation of GTPase activity	biological_process	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]
EOG88PQ0M	GO:0030676	1/111	Rac guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG88PQ0M	GO:0007155	1/111	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG88PQ0M	GO:0007409	1/111	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG88PQ0M	GO:0007424	1/111	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG88PQ0M	GO:0035011	1/111	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG88PQ0M	GO:0008360	1/111	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8NW22Z	GO:0016021	69/289	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NW22Z	GO:0004930	45/289	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8NW22Z	GO:0004935	13/289	adrenergic receptor activity	molecular_function	"Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274]
EOG8NW22Z	GO:0005886	11/289	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8NW22Z	GO:0004993	7/289	serotonin receptor activity	molecular_function	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai]
EOG8NW22Z	GO:0043565	4/289	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NW22Z	GO:0004715	4/289	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8NW22Z	GO:0003700	4/289	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NW22Z	GO:0007186	3/289	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8NW22Z	GO:0010579	3/289	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	biological_process	"Any process that increases the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G-protein coupled receptor signaling pathway." [GOC:dph, GOC:signaling, GOC:tb]
EOG8NW22Z	GO:0008227	3/289	G-protein coupled amine receptor activity	molecular_function	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
EOG8NW22Z	GO:0004989	3/289	octopamine receptor activity	molecular_function	"Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [CHEBI:17134, GOC:ai]
EOG8NW22Z	GO:0005887	3/289	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NW22Z	GO:0007189	3/289	adenylate cyclase-activating G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
EOG8NW22Z	GO:0004977	2/289	melanocortin receptor activity	molecular_function	"Combining with melanocortin to initiate a change in cell activity." [GOC:ai]
EOG8NW22Z	GO:0045886	1/289	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8NW22Z	GO:0007188	1/289	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194]
EOG8NW22Z	GO:0045887	1/289	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8P2SG2	GO:0008270	31/124	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8P2SG2	GO:0003677	22/124	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8P2SG2	GO:0004402	2/124	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8P2SG2	GO:0016589	1/124	NURF complex	cellular_component	"An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters." [GOC:bf, GOC:krc, PMID:10779516, PMID:11279013, PMID:15284901, PMID:16568949, PMID:21810179]
EOG8P2SG2	GO:0042766	1/124	nucleosome mobilization	biological_process	"The movement of nucleosomes along a DNA fragment." [PMID:12006495]
EOG8P2SG2	GO:0046331	1/124	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8P2SG2	GO:0006325	1/124	chromatin organization	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
EOG8P2SG2	GO:0045824	1/124	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG8P2SG2	GO:0035064	1/124	methylated histone binding	molecular_function	"Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf, PMID:14585615]
EOG8P2SG2	GO:0006338	1/124	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG8P2SG2	GO:0007095	1/124	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8P2SG2	GO:0006351	1/124	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8P2SG2	GO:0048515	1/124	spermatid differentiation	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid]
EOG8P2SG2	GO:0035076	1/124	ecdysone receptor-mediated signaling pathway	biological_process	"The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf]
EOG8P2SG2	GO:0045747	1/124	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8P2SG2	GO:0030097	1/124	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG8P2SG2	GO:0006357	1/124	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8P2SG2	GO:0010468	1/124	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8P2SG2	GO:0048813	1/124	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8P2SG2	GO:0070577	1/124	lysine-acetylated histone binding	molecular_function	"Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]
EOG8P2SG2	GO:0016922	1/124	ligand-dependent nuclear receptor binding	molecular_function	"Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein." [GOC:mah, PMID:7776974]
EOG8P2SG2	GO:0046426	1/124	negative regulation of JAK-STAT cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG8P2SG2	GO:0035073	1/124	pupariation	biological_process	"The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
EOG8P2SG3	GO:0045859	1/105	regulation of protein kinase activity	biological_process	"Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
EOG8P2SG3	GO:0009047	1/105	dosage compensation by hyperactivation of X chromosome	biological_process	"Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577]
EOG8P2SG3	GO:0005737	1/105	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8P2SG3	GO:0008023	1/105	transcription elongation factor complex	cellular_component	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]
EOG8P2SG3	GO:0016301	1/105	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8P2SG3	GO:0006351	1/105	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8P2SG3	GO:0003676	1/105	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8P2SG3	GO:0008607	1/105	phosphorylase kinase regulator activity	molecular_function	"Modulation of the activity of the enzyme phosphorylase kinase." [EC:2.7.11.19]
EOG8P2SG3	GO:0016246	1/105	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG8P2SG3	GO:0006357	1/105	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8P2SG3	GO:0000166	1/105	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8S7N57	GO:0016559	21/64	peroxisome fission	biological_process	"The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507]
EOG8S7N57	GO:0005779	21/64	integral component of peroxisomal membrane	cellular_component	"The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah]
EOG8S7N57	GO:0007031	1/64	peroxisome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
EOG8S7N56	GO:0000287	26/87	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8S7N56	GO:0008253	26/87	5'-nucleotidase activity	molecular_function	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]
EOG8S7N56	GO:0005737	25/87	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8S7N56	GO:0016298	3/87	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG8S7N56	GO:0006629	3/87	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8S7N56	GO:0008252	1/87	nucleotidase activity	molecular_function	"Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [EC:3.1.3.31]
EOG8S7N56	GO:0000166	1/87	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8S7N56	GO:0009158	1/87	ribonucleoside monophosphate catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
EOG8S7N56	GO:0009117	1/87	nucleotide metabolic process	biological_process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]
EOG8S7N56	GO:1901069	1/87	guanosine-containing compound catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of guanosine-containing compounds (guanosines)." [GOC:TermGenie]
EOG8S7N56	GO:0005829	1/87	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8S7N56	GO:0016311	1/87	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG81C9C7	GO:0016021	60/123	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81C9C7	GO:0015078	60/123	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG81C9C7	GO:0015991	60/123	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG81C9C7	GO:0033179	57/123	proton-transporting V-type ATPase, V0 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG81C9C7	GO:0016787	4/123	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG81C9C7	GO:0000220	3/123	vacuolar proton-transporting V-type ATPase, V0 domain	cellular_component	"The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG81C9C7	GO:0045169	1/123	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG81C9C7	GO:0007476	1/123	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG81C9C7	GO:0005774	1/123	vacuolar membrane	cellular_component	"The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]
EOG81C9C7	GO:0033181	1/123	plasma membrane proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
EOG81C9C7	GO:0033227	1/123	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG81C9C7	GO:0006909	1/123	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG80VZ4Q	GO:0000139	1/92	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG80VZ4Q	GO:0015031	1/92	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG80VZ4Q	GO:0000301	1/92	retrograde transport, vesicle recycling within Golgi	biological_process	"The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363]
EOG80VZ4Q	GO:0070273	1/92	phosphatidylinositol-4-phosphate binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah]
EOG80VZ4Q	GO:0007224	1/92	smoothened signaling pathway	biological_process	"A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
EOG80VZ4Q	GO:0005794	1/92	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG80VZ4Q	GO:0031985	1/92	Golgi cisterna	cellular_component	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]
EOG81C9C2	GO:0016021	2/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81C9C2	GO:0007229	2/9	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG81C9C2	GO:0007155	2/9	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG81C9C2	GO:0007275	1/9	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG81C9C2	GO:0004872	1/9	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8QC3KG	GO:0004872	24/102	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8QC3KG	GO:0007275	23/102	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8QC3KG	GO:0016021	13/102	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QC3KG	GO:0016020	11/102	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QC3KG	GO:0008039	1/102	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG89CSPQ	GO:0003676	21/102	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8T1M18	GO:0005524	3/108	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8T1M18	GO:0017111	3/108	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8T1M18	GO:0006281	1/108	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8T1M18	GO:0009378	1/108	four-way junction helicase activity	molecular_function	"Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [GOC:jl, PMID:9442895]
EOG8T1M18	GO:0006310	1/108	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8P5NQN	GO:0005737	26/96	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8P5NQN	GO:0008104	1/96	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8P5NQN	GO:0042052	1/96	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8P5NQN	GO:0045313	1/96	rhabdomere membrane biogenesis	biological_process	"A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane." [GOC:jl]
EOG8P5NQN	GO:0006937	1/96	regulation of muscle contraction	biological_process	"Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators]
EOG8P5NQN	GO:0045202	1/96	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8P5NQN	GO:0005886	1/96	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8P5NQN	GO:0048488	1/96	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8P5NQN	GO:0006887	1/96	exocytosis	biological_process	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
EOG8P5NQN	GO:0032154	1/96	cleavage furrow	cellular_component	"In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409]
EOG8P5NQN	GO:0007269	1/96	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8P5NQB	GO:0016020	20/138	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG844P09	GO:0016021	2/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG844P09	GO:0030100	1/96	regulation of endocytosis	biological_process	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]
EOG844P09	GO:0000281	1/96	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG844P09	GO:0016079	1/96	synaptic vesicle exocytosis	biological_process	"Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
EOG844P09	GO:0048488	1/96	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG844P09	GO:0007602	1/96	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG844P09	GO:0007268	1/96	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG844P09	GO:0045202	1/96	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG889719	GO:0005524	280/803	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG889719	GO:0016021	278/803	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG889719	GO:0042626	272/803	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG889719	GO:0008559	6/803	xenobiotic-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44]
EOG889719	GO:0032440	5/803	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG889719	GO:0003676	2/803	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG889719	GO:0016887	2/803	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG889719	GO:0008270	2/803	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG889719	GO:0042060	1/803	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG889719	GO:0000776	1/803	kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG889719	GO:0048190	1/803	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG889719	GO:0006200	1/803	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG889719	GO:0034508	1/803	centromere complex assembly	biological_process	"The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw]
EOG889719	GO:0046688	1/803	response to copper ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai]
EOG889719	GO:0034059	1/803	response to anoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:kmv]
EOG889719	GO:0046331	1/803	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG889719	GO:0007275	1/803	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG889719	GO:0010043	1/803	response to zinc ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm]
EOG889719	GO:0031427	1/803	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG889719	GO:0001666	1/803	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG889719	GO:0043492	1/803	ATPase activity, coupled to movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance." [GOC:jl]
EOG8003ZG	GO:0043565	20/88	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8003ZG	GO:0003700	19/88	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8003ZG	GO:0046872	6/88	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8003ZG	GO:0003676	2/88	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8003ZG	GO:0005634	2/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8003ZG	GO:0010866	1/88	regulation of triglyceride biosynthetic process	biological_process	"Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb]
EOG8003ZG	GO:0002385	1/88	mucosal immune response	biological_process	"An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
EOG8003ZG	GO:0031453	1/88	positive regulation of heterochromatin assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of heterochromatin formation." [GOC:mah]
EOG8003ZG	GO:0031618	1/88	nuclear pericentric heterochromatin	cellular_component	"Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [GOC:mah, PMID:20206496, PMID:22729156, PMID:9413993]
EOG8003ZG	GO:0051403	1/88	stress-activated MAPK cascade	biological_process	"A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase." [GOC:ai, PMID:15936270]
EOG8003ZG	GO:0045944	1/88	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8003ZG	GO:0005701	1/88	polytene chromosome chromocenter	cellular_component	"A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012]
EOG8003ZG	GO:0009651	1/88	response to salt stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]
EOG8003ZG	GO:0005509	1/88	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8003ZG	GO:0070829	1/88	heterochromatin maintenance	biological_process	"The chromatin organization process that preserves heterochromatin in a stable functional or structural state." [GOC:mah]
EOG8003ZG	GO:0001077	1/88	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG8003ZG	GO:0042803	1/88	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8003ZG	GO:0034605	1/88	cellular response to heat	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]
EOG8003ZG	GO:0005704	1/88	polytene chromosome band	cellular_component	"A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342]
EOG8003ZG	GO:0030431	1/88	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8003ZG	GO:0071470	1/88	cellular response to osmotic stress	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
EOG8FJBR5	GO:0008270	1/185	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FJBR5	GO:0003677	1/185	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8P5NQQ	GO:0006470	39/111	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8P5NQQ	GO:0004722	39/111	protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
EOG8P5NQQ	GO:0046872	39/111	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8P5NQQ	GO:0003824	1/111	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8003ZH	GO:0007608	1/87	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8MD0DF	GO:0030246	21/93	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8MD0DF	GO:0007155	2/93	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8MD0DF	GO:0005618	1/93	cell wall	cellular_component	"The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins." [GOC:giardia, http://en.wikipedia.org/wiki/Microbial_cyst, ISBN:0198547684, PMID:15134259]
EOG8MD0DF	GO:0005886	1/93	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8MD0DF	GO:0004180	1/93	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8003Z0	GO:0016887	27/102	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8003Z0	GO:0005524	27/102	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8003Z0	GO:0006461	3/102	protein complex assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai]
EOG8003Z0	GO:0005634	3/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8003Z0	GO:0051116	1/102	cobaltochelatase activity	molecular_function	"Catalysis of the reaction: ATP + Co(2+) + H(2)O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H(+) + phosphate." [EC:6.6.1.2, RHEA:15344]
EOG8FXTPR	GO:0003677	17/116	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FXTPR	GO:0046872	4/116	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8FXTPR	GO:0003676	2/116	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SR09K	GO:0016301	3/106	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8SR09K	GO:0005737	1/106	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SR09K	GO:0017112	1/106	Rab guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8SR09K	GO:0016192	1/106	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8SR09K	GO:1902041	1/106	regulation of extrinsic apoptotic signaling pathway via death domain receptors	biological_process	"Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429]
EOG8SR09K	GO:0004819	1/106	glutamine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18]
EOG8SR09K	GO:0016021	1/106	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SR09K	GO:0006425	1/106	glutaminyl-tRNA aminoacylation	biological_process	"The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8SR09K	GO:0006915	1/106	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8SR09K	GO:0032313	1/106	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8SR09K	GO:0051726	1/106	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8SR09K	GO:0008021	1/106	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8SR09K	GO:0000187	1/106	activation of MAPK activity	biological_process	"The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267]
EOG8SR09K	GO:0007269	1/106	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8SR09K	GO:0005524	1/106	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88971B	GO:0005524	59/204	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88971B	GO:0004713	35/204	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG88971B	GO:0016021	30/204	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88971B	GO:0004714	21/204	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG88971B	GO:0007169	19/204	transmembrane receptor protein tyrosine kinase signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
EOG88971B	GO:0016020	13/204	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG88971B	GO:0004672	4/204	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG88971B	GO:0061327	1/204	anterior Malpighian tubule development	biological_process	"The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG88971B	GO:0045087	1/204	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG88971B	GO:0007015	1/204	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG88971B	GO:0043066	1/204	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG88971B	GO:0045610	1/204	regulation of hemocyte differentiation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG88971B	GO:0007419	1/204	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG88971B	GO:0038202	1/204	TORC1 signaling	biological_process	"A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]
EOG88971B	GO:0008360	1/204	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG88971B	GO:0036335	1/204	intestinal stem cell homeostasis	biological_process	"Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells." [GOC:nhn, PMID:22042863]
EOG88971B	GO:0035099	1/204	hemocyte migration	biological_process	"The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551]
EOG88971B	GO:0019730	1/204	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG88971B	GO:0030031	1/204	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG88971B	GO:0007443	1/204	Malpighian tubule morphogenesis	biological_process	"The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089]
EOG88971B	GO:0048803	1/204	imaginal disc-derived male genitalia morphogenesis	biological_process	"The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu]
EOG88971B	GO:0007298	1/204	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG88971B	GO:0007435	1/204	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG88971B	GO:0000022	1/204	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG88971B	GO:0043410	1/204	positive regulation of MAPK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]
EOG88971B	GO:0030097	1/204	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG88971B	GO:0005886	1/204	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG88971B	GO:0006468	1/204	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG88971B	GO:0005515	1/204	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG88971B	GO:0007516	1/204	hemocyte development	biological_process	"The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG88971B	GO:0006974	1/204	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG88971B	GO:0018108	1/204	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG88971B	GO:0035172	1/204	hemocyte proliferation	biological_process	"The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG88971B	GO:0032869	1/204	cellular response to insulin stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]
EOG88971B	GO:0030036	1/204	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8P5NQ9	GO:0006281	2/37	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8P5NQ9	GO:0000723	2/37	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8P5NQ9	GO:0003678	2/37	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8P5NQ9	GO:0004386	1/37	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8P5NQ9	GO:0004519	1/37	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8FXTPF	GO:0016021	28/105	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FXTPF	GO:0043565	24/105	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8FXTPF	GO:0003700	23/105	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8FXTPF	GO:0005634	13/105	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FXTPF	GO:0006641	1/105	triglyceride metabolic process	biological_process	"The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732]
EOG8FXTPF	GO:0046889	1/105	positive regulation of lipid biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
EOG8FXTPF	GO:0050291	1/105	sphingosine N-acyltransferase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]
EOG8FXTPF	GO:0050995	1/105	negative regulation of lipid catabolic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
EOG8FXTPF	GO:0006355	1/105	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8FXTPF	GO:0003677	1/105	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FXTPF	GO:0032933	1/105	SREBP signaling pathway	biological_process	"A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription." [GOC:bf, GOC:mah, GOC:signaling, GOC:vw, PMID:12923525, PMID:22017871]
EOG8FXTPF	GO:0046513	1/105	ceramide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]
EOG844P0C	GO:0008270	24/87	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG844P0C	GO:0004181	24/87	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG844P0H	GO:0016301	2/105	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG844P0H	GO:0004385	2/105	guanylate kinase activity	molecular_function	"Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8]
EOG844P0H	GO:0008582	1/105	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG844P0H	GO:0048812	1/105	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG844P0H	GO:0071212	1/105	subsynaptic reticulum	cellular_component	"An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:1460464, PMID:18171947, PMID:19244343, PMID:7946331]
EOG8Z0DM3	GO:0005925	1/89	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8Z0DM3	GO:0007016	1/89	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG8Z0DM3	GO:0030011	1/89	maintenance of cell polarity	biological_process	"The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8Z0DM3	GO:0016337	1/89	single organismal cell-cell adhesion	biological_process	"The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb]
EOG8Z0DM3	GO:0007414	1/89	axonal defasciculation	biological_process	"Separation of axons away from a bundle of axons known as a fascicle." [GOC:dgh, ISBN:039751820X]
EOG8P2SGG	GO:0003676	1/11	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8P2SGG	GO:0006260	1/11	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8P2SGG	GO:0043140	1/11	ATP-dependent 3'-5' DNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl]
EOG8P2SGG	GO:0005524	1/11	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8P2SGG	GO:0005622	1/11	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8P2SGG	GO:0006281	1/11	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8P2SGN	GO:0008021	22/88	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8P2SGN	GO:0005215	22/88	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8P2SGN	GO:0016020	21/88	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8P2SGN	GO:0035005	1/88	1-phosphatidylinositol-4-phosphate 3-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.154, RHEA:18376]
EOG8P2SGN	GO:0016324	1/88	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8P2SGN	GO:0007269	1/88	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8P2SGN	GO:0003824	1/88	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8P2SGN	GO:0045211	1/88	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8P2SGN	GO:0016079	1/88	synaptic vesicle exocytosis	biological_process	"Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
EOG8P2SGN	GO:0005544	1/88	calcium-dependent phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]
EOG8P2SGN	GO:0001786	1/88	phosphatidylserine binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]
EOG8P2SGN	GO:0016192	1/88	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8P2SGN	GO:0031594	1/88	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8P2SGN	GO:0004252	1/88	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8P2SGN	GO:0031982	1/88	vesicle	cellular_component	"Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz]
EOG8P2SGN	GO:0031340	1/88	positive regulation of vesicle fusion	biological_process	"Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah]
EOG8P2SGN	GO:0048167	1/88	regulation of synaptic plasticity	biological_process	"A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290]
EOG8P2SGN	GO:0046928	1/88	regulation of neurotransmitter secretion	biological_process	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
EOG8P2SGN	GO:0000149	1/88	SNARE binding	molecular_function	"Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]
EOG8QC3K3	GO:0030246	11/81	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8QC3K3	GO:0016787	2/81	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8QC3K3	GO:0004714	1/81	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8P2SGJ	GO:0097206	1/79	nephrocyte filtration	biological_process	"The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929]
EOG8P2SGJ	GO:0046331	1/79	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG88PQ02	GO:0005509	24/107	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG88PQ02	GO:0005089	7/107	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG88PQ02	GO:0045179	1/107	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG88PQ02	GO:0016740	1/107	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG88PQ02	GO:0005515	1/107	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG88PQ02	GO:0045860	1/107	positive regulation of protein kinase activity	biological_process	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
EOG88PQ02	GO:0005886	1/107	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG88PQ02	GO:0048488	1/107	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG88PQ02	GO:0000166	1/107	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG88PQ02	GO:0005737	1/107	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG88PQ02	GO:0008104	1/107	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG88PQ02	GO:0002052	1/107	positive regulation of neuroblast proliferation	biological_process	"Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph]
EOG88PQ02	GO:0051124	1/107	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG88PQ02	GO:0045746	1/107	negative regulation of Notch signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG88PQ02	GO:0008021	1/107	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG88PQ02	GO:0007269	1/107	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8S7N5S	GO:0030234	16/259	enzyme regulator activity	molecular_function	"Binds to and modulates the activity of an enzyme." [GOC:mah]
EOG8S7N5S	GO:0005509	16/259	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8S7N5S	GO:0090256	1/259	regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis	biological_process	"Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8S7N5S	GO:0005615	1/259	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8S7N5S	GO:0032504	1/259	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8S7N5S	GO:0042302	1/259	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8S7N5S	GO:0005811	1/259	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8S7N5S	GO:0005576	1/259	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8S7N5S	GO:0005829	1/259	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8S7N5S	GO:0009631	1/259	cold acclimation	biological_process	"Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr]
EOG8S7N5S	GO:0044720	1/259	negative regulation of imaginal disc-derived wing size	biological_process	"Any process that reduces the size of an imaginal disc-derived wing." [PMID:21393605]
EOG8P2SGS	GO:0016021	6/204	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8P2SGS	GO:0055085	5/204	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8P2SGS	GO:0005886	1/204	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8P2SGS	GO:0003009	1/204	skeletal muscle contraction	biological_process	"A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle]
EOG8S7N5W	GO:0005576	8/49	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8S7N5W	GO:0005615	3/49	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8K9DVG	GO:0042073	1/100	intraciliary transport	biological_process	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374]
EOG8K9DVG	GO:0000922	1/100	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8K9DVG	GO:0005875	1/100	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8K9DVG	GO:0005515	1/100	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8K9DVG	GO:0000242	1/100	pericentriolar material	cellular_component	"A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]
EOG8K9DVG	GO:0007279	1/100	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8K9DVG	GO:0005813	1/100	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8K9DVG	GO:0008017	1/100	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8K9DVG	GO:0000235	1/100	astral microtubule	cellular_component	"Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194]
EOG8K9DVG	GO:0007143	1/100	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8K9DVG	GO:0007067	1/100	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8K9DVG	GO:0007097	1/100	nuclear migration	biological_process	"The directed movement of the nucleus." [GOC:ai]
EOG8K9DVG	GO:0007344	1/100	pronuclear fusion	biological_process	"The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X]
EOG8K9DVG	GO:0008104	1/100	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8K9DVG	GO:0005876	1/100	spindle microtubule	cellular_component	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]
EOG8K9DVG	GO:0007052	1/100	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8K9DVG	GO:0007026	1/100	negative regulation of microtubule depolymerization	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]
EOG8K9DVG	GO:0000226	1/100	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8K9DVG	GO:0035046	1/100	pronuclear migration	biological_process	"The directed movement of the male and female pronuclei towards each other prior to their fusion." [GOC:bf, PMID:9199363]
EOG8SFCMS	GO:0008270	12/102	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SFCMS	GO:0003676	11/102	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SFCMS	GO:0003677	1/102	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8J3ZZ0	GO:0003677	16/36	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG83BQ37	GO:0005097	17/58	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG83BQ37	GO:0008168	1/58	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG83BQ37	GO:0003676	1/58	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80ZTF5	GO:0006351	22/81	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG80ZTF5	GO:0003899	22/81	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG80ZTF5	GO:0000166	22/81	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG88D39V	GO:0003677	1/10	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG88D39V	GO:0006355	1/10	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG81NX3C	GO:0004190	1/9	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG81NX3C	GO:0003964	1/9	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG81NX3C	GO:0003723	1/9	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8WM792	GO:0006412	27/109	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8WM792	GO:0005840	27/109	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8WM792	GO:0003735	27/109	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8WM792	GO:0007052	1/109	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8WM792	GO:0000022	1/109	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8WM792	GO:0005737	1/109	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WM792	GO:0043025	1/109	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8WM792	GO:0051298	1/109	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8WM792	GO:0051297	1/109	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8K9DVV	GO:0003676	2/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K9DVV	GO:0046872	2/7	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG87WR46	GO:0006412	27/95	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG87WR46	GO:0005840	27/95	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG87WR46	GO:0003735	27/95	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG87WR46	GO:0000022	1/95	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG87WR46	GO:0005515	1/95	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG87WR46	GO:0007052	1/95	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG87WR46	GO:0005737	1/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87WR46	GO:0000228	1/95	nuclear chromosome	cellular_component	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
EOG87WR46	GO:0051298	1/95	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG87WR46	GO:0019843	1/95	rRNA binding	molecular_function	"Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl]
EOG87WR46	GO:0005730	1/95	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG87WR46	GO:0005703	1/95	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG825878	GO:0022008	1/93	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG89625W	GO:0010508	1/97	positive regulation of autophagy	biological_process	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG89625W	GO:0046330	1/97	positive regulation of JNK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG89625W	GO:0005737	1/97	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG89625W	GO:0030054	1/97	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG89625W	GO:0034599	1/97	cellular response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
EOG89625W	GO:0009267	1/97	cellular response to starvation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]
EOG8KM1JD	GO:0006355	3/28	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8KM1JD	GO:0003677	3/28	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8BCH3F	GO:0003700	27/104	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8BCH3F	GO:0005634	26/104	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BCH3F	GO:0000976	19/104	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8BCH3F	GO:0043565	8/104	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8BCH3F	GO:0007411	1/104	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8BCH3F	GO:0004000	1/104	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8BCH3F	GO:0048663	1/104	neuron fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph]
EOG82FW0Q	GO:0016020	21/78	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82FW0Q	GO:0035556	21/78	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG82FW0Q	GO:0016192	1/78	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8HHRHN	GO:0018580	1/71	nitronate monooxygenase activity	molecular_function	"Catalysis of the reaction: ethylnitronate + O(2) = acetaldehyde + nitrite." [EC:1.13.12.16, RHEA:28770]
EOG8BZQH1	GO:0004252	24/97	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8BZQH1	GO:0051017	1/97	actin filament bundle assembly	biological_process	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
EOG8BZQH1	GO:0006508	1/97	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8BZQH1	GO:0016021	1/97	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BZQH1	GO:0005886	1/97	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8BZQH1	GO:0035220	1/97	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8BZQH1	GO:0007010	1/97	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8HHRH5	GO:0003774	26/71	motor activity	molecular_function	"Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
EOG8HHRH5	GO:0016459	26/71	myosin complex	cellular_component	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
EOG8HHRH5	GO:0005524	26/71	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8HHRH5	GO:0016887	1/71	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8BZQHM	GO:0016042	1/103	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8BZQHM	GO:0005576	1/103	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8BZQHM	GO:0046843	1/103	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8BZQHM	GO:0002121	1/103	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8BZQHM	GO:0016787	1/103	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8BZQHM	GO:0007444	1/103	imaginal disc development	biological_process	"The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238]
EOG8323CG	GO:0006486	1/99	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8323CG	GO:0000398	1/99	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8323CG	GO:0008378	1/99	galactosyltransferase activity	molecular_function	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]
EOG8323CG	GO:0016020	1/99	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8323CG	GO:0071011	1/99	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8323CG	GO:0022008	1/99	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8HHRH3	GO:0005634	20/79	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HHRH3	GO:0003700	20/79	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8HHRH3	GO:0000976	13/79	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8HHRH3	GO:0043565	7/79	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8HHRH3	GO:0007275	1/79	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8BZQHG	GO:0005506	74/262	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8BZQHG	GO:0020037	74/262	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8BZQHG	GO:0016705	69/262	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8BZQHG	GO:0004497	66/262	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8BZQHG	GO:0004501	3/262	ecdysone 20-monooxygenase activity	molecular_function	"Catalysis of the reaction: AH(2) + Ecdysone + O(2) = 20-hydroxyecdysone + A + H(2)O." [EC:1.14.99.22, RHEA:14024]
EOG8BZQHG	GO:0008386	2/262	cholesterol monooxygenase (side-chain-cleaving) activity	molecular_function	"Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6]
EOG8BZQHG	GO:0031966	2/262	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG8BZQHG	GO:0007494	1/262	midgut development	biological_process	"The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
EOG8BZQHG	GO:0042767	1/262	ecdysteroid 22-hydroxylase activity	molecular_function	"Catalysis of the hydroxylation of an ecdysteroid at carbon position 22." [PMID:12177427]
EOG8BZQHG	GO:0005789	1/262	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8BZQHG	GO:0006697	1/262	ecdysone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732]
EOG8BZQHG	GO:0009055	1/262	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8BZQHG	GO:0008362	1/262	chitin-based embryonic cuticle biosynthetic process	biological_process	"Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232]
EOG8BZQHG	GO:0005739	1/262	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8BZQHG	GO:0008258	1/262	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8BZQHG	GO:0007490	1/262	tergite morphogenesis	biological_process	"The process in which the anatomical structures of the tergite are generated and organized. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment." [GOC:jid, http://www.earthlife.net]
EOG8BZQHG	GO:0007391	1/262	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8BZQHG	GO:0007417	1/262	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8HHRH8	GO:0003677	25/89	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8HHRH8	GO:0006260	24/89	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8HHRH8	GO:0017111	16/89	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8HHRH8	GO:0000166	15/89	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8HHRH8	GO:0022008	1/89	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8HHRH8	GO:0003887	1/89	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8HHRH8	GO:0005524	1/89	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8HHRH8	GO:0005875	1/89	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8GXJ4K	GO:0008270	23/103	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GXJ4K	GO:0022008	1/103	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8GXJ4K	GO:0034472	1/103	snRNA 3'-end processing	biological_process	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]
EOG8BCH32	GO:0003676	9/15	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BCH32	GO:0046872	9/15	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83BQ3X	GO:0007281	1/98	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG83BQ3X	GO:0005737	1/98	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83BQ3X	GO:0019099	1/98	female germ-line sex determination	biological_process	"The determination of sex and sexual phenotype in a female organism's germ line." [GOC:mah]
EOG83BQ3X	GO:0018992	1/98	germ-line sex determination	biological_process	"The determination of sex and sexual phenotype in an organism's germ line." [GOC:ems]
EOG83BQ3X	GO:0048134	1/98	germ-line cyst formation	biological_process	"Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920]
EOG83BQ3X	GO:0051276	1/98	chromosome organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG83BQ3X	GO:0048477	1/98	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG83BQ3X	GO:0032877	1/98	positive regulation of DNA endoreduplication	biological_process	"Any process that activates or increases the frequency, rate or extent of DNA endoreduplication." [GOC:mah]
EOG83BQ3W	GO:0016021	9/40	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83BQ3W	GO:0006633	9/40	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG83BQ3W	GO:0016717	9/40	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]
EOG83BQ3W	GO:0006629	1/40	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG83BQ3W	GO:0004768	1/40	stearoyl-CoA 9-desaturase activity	molecular_function	"Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1]
EOG85B3VR	GO:0004252	25/73	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG85B3VR	GO:0003824	4/73	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG85B3VR	GO:0030246	1/73	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG85B3VR	GO:0006508	1/73	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG85B3VR	GO:0045087	1/73	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG82587J	GO:0016021	30/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82587J	GO:0055085	24/96	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG82587J	GO:0006810	4/96	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG82587J	GO:0006839	2/96	mitochondrial transport	biological_process	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]
EOG82587J	GO:0031966	2/96	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG8K9DV7	GO:0005576	8/34	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8K9DV7	GO:0001558	8/34	regulation of cell growth	biological_process	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8K9DV7	GO:0008233	1/34	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8TXF82	GO:0005576	1/45	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG85B3VN	GO:0016887	2/11	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG85B3VN	GO:0005524	2/11	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG85B3VN	GO:0005215	1/11	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG85B3VN	GO:0016020	1/11	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82587Q	GO:0008289	19/93	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG87WR4P	GO:0008355	2/112	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG87WR4P	GO:0005783	2/112	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG87WR4P	GO:0007298	2/112	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG87WR4P	GO:0008284	2/112	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG87WR4P	GO:0016318	1/112	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG87WR4P	GO:0007438	1/112	oenocyte development	biological_process	"The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397]
EOG87WR4P	GO:0043066	1/112	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG87WR4P	GO:0035225	1/112	determination of genital disc primordium	biological_process	"Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318]
EOG87WR4P	GO:0042058	1/112	regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG87WR4P	GO:0000086	1/112	G2/M transition of mitotic cell cycle	biological_process	"The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle]
EOG87WR4P	GO:0046673	1/112	negative regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG87WR4P	GO:0016021	1/112	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87WR4P	GO:0007432	1/112	salivary gland boundary specification	biological_process	"Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957]
EOG87WR4P	GO:0048149	1/112	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG87WR4P	GO:0007421	1/112	stomatogastric nervous system development	biological_process	"The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jid]
EOG87WR4P	GO:0003015	1/112	heart process	biological_process	"A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]
EOG87WR4P	GO:0005576	1/112	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG87WR4P	GO:0061331	1/112	epithelial cell proliferation involved in Malpighian tubule morphogenesis	biological_process	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG87WR4P	GO:0007422	1/112	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG87WR4P	GO:0005789	1/112	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG87WR4P	GO:0050769	1/112	positive regulation of neurogenesis	biological_process	"Any process that activates or increases the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]
EOG87WR4P	GO:0005886	1/112	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG87WR4P	GO:0000139	1/112	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG87WR4P	GO:0048749	1/112	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG87WR4P	GO:0045742	1/112	positive regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG87WR4P	GO:0046845	1/112	branched duct epithelial cell fate determination, open tracheal system	biological_process	"Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581]
EOG87WR4P	GO:0005515	1/112	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG87WR4P	GO:0045470	1/112	R8 cell-mediated photoreceptor organization	biological_process	"The regionalization process that coordinates the recruitment and organization of other non-R8 photoreceptors by the R8 photoreceptor." [PMID:11880339]
EOG87WR4P	GO:0022008	1/112	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG87WR4P	GO:0016330	1/112	second mitotic wave involved in compound eye morphogenesis	biological_process	"A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224]
EOG87WR4P	GO:0007476	1/112	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG87WR4P	GO:0007424	1/112	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG87WR4P	GO:0035277	1/112	spiracle morphogenesis, open tracheal system	biological_process	"The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268]
EOG87WR4P	GO:0045741	1/112	positive regulation of epidermal growth factor-activated receptor activity	biological_process	"Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators]
EOG87WR4P	GO:0005794	1/112	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG87WR4P	GO:0000165	1/112	MAPK cascade	biological_process	"An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267]
EOG87WR4P	GO:0007173	1/112	epidermal growth factor receptor signaling pathway	biological_process	"A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933]
EOG87WR4P	GO:0005154	1/112	epidermal growth factor receptor binding	molecular_function	"Interacting selectively and non-covalently with the epidermal growth factor receptor." [GOC:ai]
EOG87WR4P	GO:0048865	1/112	stem cell fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete]
EOG8K9DV8	GO:0015074	1/50	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8K9DV8	GO:0003676	1/50	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85B3VG	GO:0016020	20/52	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG85B3VG	GO:0004872	20/52	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG85B3VG	GO:0007275	19/52	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG85B3VG	GO:0001700	1/52	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG81G5HX	GO:0005524	29/111	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG81G5HX	GO:0004674	23/111	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG81G5HX	GO:0004672	5/111	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG81G5HX	GO:0003743	2/111	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG81G5HX	GO:0045793	1/111	positive regulation of cell size	biological_process	"Any process that increases cell size." [GOC:go_curators]
EOG81G5HX	GO:0032440	1/111	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG81G5HX	GO:0006446	1/111	regulation of translational initiation	biological_process	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG81G5HX	GO:0004713	1/111	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG81G5HX	GO:0000398	1/111	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG81G5HX	GO:0071013	1/111	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG81G5HX	GO:0005829	1/111	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG81G5HX	GO:0006417	1/111	regulation of translation	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG81G5HX	GO:0004821	1/111	histidine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [EC:6.1.1.21]
EOG81G5HX	GO:0071011	1/111	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG81G5HX	GO:0006468	1/111	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG81G5HX	GO:0008353	1/111	RNA polymerase II carboxy-terminal domain kinase activity	molecular_function	"Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah]
EOG81G5HX	GO:0004686	1/111	elongation factor-2 kinase activity	molecular_function	"Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate." [EC:2.7.11.20, MetaCyc:2.7.11.20-RXN]
EOG8G4K6T	GO:0008270	6/22	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8G4K6T	GO:0003676	6/22	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VX4K3	GO:0005524	51/166	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VX4K3	GO:0016887	50/166	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8VX4K3	GO:0015438	1/166	teichoic-acid-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)." [EC:3.6.3.40]
EOG8VX4K3	GO:0015408	1/166	ferric-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [EC:3.6.3.30]
EOG8VX4K2	GO:0043984	13/18	histone H4-K16 acetylation	biological_process	"The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone." [GOC:jl]
EOG8VX4K2	GO:0072487	13/18	MSL complex	cellular_component	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852]
EOG8VX4K2	GO:0045433	1/18	male courtship behavior, veined wing generated song production	biological_process	"The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
EOG8JMB6G	GO:0046872	7/22	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG87Q0M8	GO:0045454	23/62	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG87Q0M8	GO:0006662	22/62	glycerol ether metabolic process	biological_process	"The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732]
EOG87Q0M8	GO:0015035	22/62	protein disulfide oxidoreductase activity	molecular_function	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]
EOG87Q0M8	GO:0003756	3/62	protein disulfide isomerase activity	molecular_function	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1]
EOG87Q0M8	GO:0047134	1/62	protein-disulfide reductase activity	molecular_function	"Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+." [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN]
EOG87Q0M8	GO:0034976	1/62	response to endoplasmic reticulum stress	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]
EOG87Q0M8	GO:0005783	1/62	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG87Q0M8	GO:0006457	1/62	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG87Q0M8	GO:0016853	1/62	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8284KJ	GO:0006351	1/5	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8284KJ	GO:0003899	1/5	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8284KJ	GO:0003677	1/5	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80KBDB	GO:0016746	22/105	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG80KBDB	GO:0004095	3/105	carnitine O-palmitoyltransferase activity	molecular_function	"Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21]
EOG80KBDB	GO:0003993	1/105	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG80KBDB	GO:0006979	1/105	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG80KBDB	GO:0010038	1/105	response to metal ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]
EOG80KBDB	GO:0042594	1/105	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG805VF4	GO:0055085	23/108	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG805VF4	GO:0016021	23/108	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PG8DP	GO:0045475	1/104	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8PG8DP	GO:0006812	1/104	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8PG8DP	GO:0005261	1/104	cation channel activity	molecular_function	"Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8PG8DP	GO:0055080	1/104	cation homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of cations within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]
EOG8PG8DP	GO:0034703	1/104	cation channel complex	cellular_component	"An ion channel complex through which cations pass." [GOC:mah]
EOG805VF1	GO:0016021	26/103	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG805VF1	GO:0000287	26/103	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG805VF1	GO:0004012	26/103	phospholipid-translocating ATPase activity	molecular_function	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684]
EOG805VF1	GO:0005524	26/103	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG805VF1	GO:0019829	24/103	cation-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]
EOG805VF1	GO:0005388	1/103	calcium-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8]
EOG805VF0	GO:0016021	70/329	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG805VF0	GO:0022857	41/329	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG805VF0	GO:0055085	29/329	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG805VF0	GO:0005215	13/329	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG805VF0	GO:0008643	1/329	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8JT2NB	GO:0031225	5/90	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG8JT2NB	GO:0005886	5/90	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8JT2NB	GO:0045187	5/90	regulation of circadian sleep/wake cycle, sleep	biological_process	"Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981]
EOG8JT2NB	GO:0034235	5/90	GPI anchor binding	molecular_function	"Interacting selectively and non-covalently with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw]
EOG8JT2NB	GO:0030431	1/90	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8JT2NB	GO:0032222	1/90	regulation of synaptic transmission, cholinergic	biological_process	"Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
EOG8JT2NB	GO:0009897	1/90	external side of plasma membrane	cellular_component	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]
EOG8JT2NB	GO:0045938	1/90	positive regulation of circadian sleep/wake cycle, sleep	biological_process	"Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators]
EOG8JT2NB	GO:0045837	1/90	negative regulation of membrane potential	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators]
EOG8F4VQV	GO:0005524	3/138	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8F4VQV	GO:0004674	2/138	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8F4VQV	GO:0032440	1/138	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8F4VQV	GO:0004672	1/138	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8F4VQV	GO:0016772	1/138	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8R268X	GO:0005230	8/35	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8R268X	GO:0005886	7/35	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8R268X	GO:0016021	7/35	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8R268X	GO:0045202	5/35	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8R268X	GO:0030054	5/35	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8R268X	GO:0016020	1/35	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8W3W45	GO:0006355	1/8	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8W3W45	GO:0003677	1/8	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8W3W45	GO:0000156	1/8	phosphorelay response regulator activity	molecular_function	"Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140]
EOG8V71WP	GO:0003677	1/100	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8TXF8G	GO:0019013	35/52	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8TXF8G	GO:0003676	8/52	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG805VFS	GO:0016021	217/605	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG805VFS	GO:0005886	209/605	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG805VFS	GO:0050909	202/605	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG805VFS	GO:0008527	21/605	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG805VFS	GO:0050912	8/605	detection of chemical stimulus involved in sensory perception of taste	biological_process	"The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG805VFS	GO:0004930	3/605	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG805VFS	GO:0030425	2/605	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG805VFS	GO:0004984	2/605	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG805VFS	GO:0017085	2/605	response to insecticide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]
EOG805VFS	GO:0030424	2/605	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG805VFS	GO:0007635	2/605	chemosensory behavior	biological_process	"Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators]
EOG805VFS	GO:0005549	2/605	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG805VFS	GO:0046957	1/605	negative phototaxis	biological_process	"The directed movement of a cell or organism away from a source of light." [GOC:ai]
EOG805VFS	GO:0007631	1/605	feeding behavior	biological_process	"Behavior associated with the intake of food." [GOC:mah]
EOG805VFS	GO:0040040	1/605	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG805VFS	GO:0031000	1/605	response to caffeine	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah]
EOG805VFS	GO:0006955	1/605	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG805VFS	GO:0007602	1/605	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG805VFS	GO:0046982	1/605	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG805VFS	GO:0008049	1/605	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG805VFS	GO:0035006	1/605	melanization defense response	biological_process	"The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809]
EOG805VFS	GO:0042742	1/605	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG805VFS	GO:0044297	1/605	cell body	cellular_component	"The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]
EOG805VFR	GO:0016021	31/98	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG805VFR	GO:0008324	31/98	cation transmembrane transporter activity	molecular_function	"Enables the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
EOG805VFR	GO:0003824	1/98	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG805VFR	GO:0071577	1/98	zinc II ion transmembrane transport	biological_process	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]
EOG805VFR	GO:0016323	1/98	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG805VFR	GO:0006777	1/98	Mo-molybdopterin cofactor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473]
EOG805VFR	GO:0032440	1/98	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG805VFR	GO:0006882	1/98	cellular zinc ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell." [GOC:ai, GOC:mah]
EOG805VFR	GO:0016324	1/98	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG805VFR	GO:0005886	1/98	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG805VFR	GO:0055069	1/98	zinc ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
EOG8TXF7W	GO:0006914	49/150	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG8TXF7W	GO:0005776	2/150	autophagosome	cellular_component	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]
EOG8TXF7W	GO:0016236	2/150	macroautophagy	biological_process	"The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure.  Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464]
EOG8TXF7W	GO:0008340	1/150	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8TXF7W	GO:0031396	1/150	regulation of protein ubiquitination	biological_process	"Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]
EOG8TXF7W	GO:0044753	1/150	amphisome	cellular_component	"An autophagosome formed upon fusion between autophagosomes and endosomes." [GOC:autophagy, GOC:sart, PMID:19008921, PMID:9705327]
EOG8TXF7W	GO:0010506	1/150	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG805VFN	GO:0004535	2/79	poly(A)-specific ribonuclease activity	molecular_function	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]
EOG8NW22F	GO:0007298	1/70	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8NW22F	GO:0005634	1/70	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NW22F	GO:0005886	1/70	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80KBD8	GO:0003676	2/43	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80KBD8	GO:0008270	2/43	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VX4KR	GO:0006511	25/83	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8VX4KR	GO:0004843	25/83	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG8VX4KR	GO:0000790	13/83	nuclear chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130]
EOG8VX4KR	GO:0035522	13/83	monoubiquitinated histone H2A deubiquitination	biological_process	"The removal of the ubiquitin group from a monoubiquitinated histone H2A protein." [GOC:bf, PMID:18226187, PMID:20436459]
EOG8VX4KR	GO:0004221	13/83	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG8VX4KR	GO:0006342	13/83	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG8VX4KR	GO:0035517	13/83	PR-DUB complex	cellular_component	"A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively." [PMID:20436459]
EOG8VX4KR	GO:0003682	13/83	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8VX4KR	GO:0005622	12/83	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8VX4KR	GO:0005524	1/83	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VX4KR	GO:0003676	1/83	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VX4KR	GO:0005634	1/83	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VX4KR	GO:0008026	1/83	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8VX4KR	GO:0007385	1/83	specification of segmental identity, abdomen	biological_process	"The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
EOG8JMB62	GO:0005549	2/6	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG82VBWN	GO:0005622	9/52	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG82VBWN	GO:0007165	9/52	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG82VBWN	GO:0005096	6/52	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG82VBWN	GO:0005089	1/52	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG879HN6	GO:0016021	18/74	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG879HN6	GO:0007523	1/74	larval visceral muscle development	biological_process	"The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid]
EOG879HN6	GO:0006869	1/74	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG879HN6	GO:0005737	1/74	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG879HN6	GO:0048471	1/74	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG879HN6	GO:0006200	1/74	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG879HN6	GO:0061024	1/74	membrane organization	biological_process	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]
EOG879HN6	GO:0005811	1/74	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG879HN6	GO:0031887	1/74	lipid particle transport along microtubule	biological_process	"The directed movement of a lipid particle along a microtubule, mediated by motor proteins." [PMID:9491895]
EOG879HN6	GO:0035149	1/74	lumen formation, open tracheal system	biological_process	"Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
EOG879HN6	GO:0030286	1/74	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG879HN6	GO:0035239	1/74	tube morphogenesis	biological_process	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]
EOG879HN6	GO:0001745	1/74	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG879HN6	GO:0005881	1/74	cytoplasmic microtubule	cellular_component	"Any microtubule in the cytoplasm of a cell." [GOC:mah]
EOG879HN6	GO:0005515	1/74	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG879HN6	GO:0051640	1/74	organelle localization	biological_process	"Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]
EOG879HN6	GO:0060361	1/74	flight	biological_process	"Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph]
EOG879HN6	GO:0007018	1/74	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG879HN6	GO:0042623	1/74	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG879HN6	GO:0007097	1/74	nuclear migration	biological_process	"The directed movement of the nucleus." [GOC:ai]
EOG879HN6	GO:0040011	1/74	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG879HN6	GO:0042051	1/74	compound eye photoreceptor development	biological_process	"The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
EOG879HN6	GO:0005635	1/74	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG8MPM52	GO:0030170	3/8	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8MPM52	GO:0008483	2/8	transaminase activity	molecular_function	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]
EOG8MPM52	GO:0009102	1/8	biotin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732]
EOG8MPM52	GO:0004015	1/8	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	molecular_function	"Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate." [EC:2.6.1.62, RHEA:16864]
EOG8MPM52	GO:0016021	1/8	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JMB63	GO:0005840	4/91	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8JMB63	GO:0003735	3/91	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8JMB63	GO:0006412	2/91	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8JMB63	GO:0006810	1/91	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8JMB63	GO:0016021	1/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JMB63	GO:0005762	1/91	mitochondrial large ribosomal subunit	cellular_component	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
EOG87Q0MH	GO:0005524	37/124	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87Q0MH	GO:0004674	33/124	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG87Q0MH	GO:0004683	3/124	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG87Q0MH	GO:0004672	2/124	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG87Q0MH	GO:0006468	1/124	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]