Domain arrangement Fusions Fissions Terminal losses Terminal emergences Single domain losses Single domain emergences PF00001 PF00151 1 0 0 0 0 0 PF00041 PF07679 PF00069 1 0 0 0 0 0 PF00053 PF00052 PF00053 PF00054 PF02210 PF00054 0 1 0 0 0 0 PF00056 0 1 0 0 0 0 PF00057 PF00089 1 0 6 0 0 0 PF00069 0 1 0 0 0 0 PF00069 PF00018 1 0 0 0 0 0 PF00069 PF10409 1 0 0 0 0 0 PF00082 PF01483 PF14843 0 1 0 0 0 0 PF00089 PF12032 PF00089 1 0 0 0 0 0 PF00090 0 2 0 0 0 0 PF00090 PF05986 PF00090 PF08686 1 0 0 0 0 0 PF00091 PF03953 PF10541 1 0 0 0 0 0 PF00097 PF01436 1 0 0 0 0 0 PF00130 PF00781 PF00609 0 1 2 0 0 0 PF00130 PF13901 1 0 0 0 0 0 PF00168 PF00595 1 0 0 0 0 0 PF00169 0 1 0 0 0 0 PF00211 0 1 0 0 0 0 PF00217 0 0 1 0 0 0 PF00225 0 1 0 0 0 0 PF00225 PF00787 1 0 0 0 0 0 PF00225 PF07776 PF13912 1 0 0 0 0 0 PF00246 PF02244 PF00246 1 0 1 0 0 0 PF00271 PF03368 PF02170 PF00636 0 1 0 0 0 0 PF00292 PF00001 1 0 0 0 0 0 PF00292 PF00046 PF00292 PF00046 1 0 0 0 0 0 PF00307 PF00402 PF13281 PF00069 1 0 0 0 0 0 PF00335 PF08385 1 0 0 0 0 0 PF00379 PF01391 1 0 0 0 0 0 PF00397 0 1 0 0 0 0 PF00400 0 1 0 0 0 0 PF00400 PF08662 PF00400 1 0 0 0 0 0 PF00412 0 1 0 0 0 0 PF00415 PF00651 PF00415 PF00651 1 0 0 0 0 0 PF00435 PF13499 PF08726 0 0 2 0 0 0 PF00439 0 1 0 0 0 0 PF00454 PF02260 0 0 8 0 0 0 PF00481 PF07145 1 0 0 0 0 0 PF00538 PF00628 PF01853 1 0 0 0 0 0 PF00551 0 0 9 0 0 0 PF00560 PF13855 PF00560 PF13855 1 0 0 0 0 0 PF00562 PF04560 0 0 7 0 0 0 PF00587 0 1 0 0 0 0 PF00595 PF15936 1 0 0 0 0 0 PF00627 0 1 0 0 0 0 PF00639 0 1 0 0 0 0 PF00646 PF00400 1 0 0 0 0 0 PF00646 PF00675 PF05193 1 0 0 0 0 0 PF00659 0 1 0 0 0 0 PF00675 PF05193 0 1 0 0 0 0 PF00685 0 1 0 0 0 0 PF00709 PF00230 1 0 0 0 0 0 PF00751 0 1 0 0 0 0 PF00787 PF00069 1 0 0 0 0 0 PF00832 0 0 0 0 1 0 PF00858 PF02958 1 0 0 0 0 0 PF00957 PF00612 1 0 0 0 0 0 PF00994 0 0 4 0 0 0 PF01000 PF03227 1 0 0 0 0 0 PF01030 PF00757 PF01030 PF07714 PF00595 1 0 0 0 0 0 PF01064 0 1 4 0 0 0 PF01239 PF02893 1 0 0 0 0 0 PF01281 0 0 0 0 1 0 PF01369 0 1 0 0 0 0 PF01399 0 1 0 0 0 0 PF01408 0 1 0 0 0 0 PF01421 0 1 0 0 0 0 PF01421 PF00090 PF05986 PF00090 0 0 1 0 0 0 PF01529 PF02014 1 0 0 0 0 0 PF01562 PF13688 0 0 2 0 0 0 PF01571 0 0 1 0 0 0 PF01582 PF00125 1 0 0 0 0 0 PF01585 0 1 0 0 0 0 PF01632 0 0 0 0 1 0 PF01753 PF00567 1 0 0 0 0 0 PF01907 0 0 0 0 1 0 PF01928 0 0 0 0 1 0 PF01936 PF11608 0 1 0 0 0 0 PF01963 PF05033 PF00856 1 0 0 0 0 0 PF02014 PF06468 PF00090 PF00014 0 1 0 0 0 0 PF02019 PF00008 1 0 0 0 0 0 PF02126 0 0 0 0 1 0 PF02146 PF02731 1 0 0 0 0 0 PF02185 PF03097 PF00595 0 1 0 0 0 0 PF02209 0 1 1 0 0 0 PF02210 0 1 0 0 0 0 PF02210 PF00008 PF02210 PF01034 1 0 0 0 0 0 PF02219 0 0 0 0 1 0 PF02262 PF02761 PF02762 PF14447 0 1 0 0 0 0 PF02318 PF00168 1 0 0 0 0 0 PF02373 PF13831 PF13832 1 0 1 0 0 0 PF02375 PF01388 PF02373 0 0 1 0 0 0 PF02463 PF01391 1 0 0 0 0 0 PF02463 PF07690 1 0 0 0 0 0 PF02709 0 0 1 0 0 0 PF02771 PF02770 0 0 1 0 0 0 PF02827 0 0 0 0 1 0 PF02837 0 0 3 0 0 0 PF02866 0 1 0 0 0 0 PF02894 0 1 0 0 0 0 PF02931 PF02932 PF00055 PF00053 1 0 0 0 0 0 PF02949 PF01532 1 0 0 0 0 0 PF02961 0 0 0 0 1 0 PF03097 PF13949 PF00102 1 0 0 0 0 0 PF03129 0 1 6 0 0 0 PF03359 PF00907 1 0 0 0 0 0 PF03474 0 1 0 0 0 0 PF03723 0 0 2 0 0 0 PF03810 0 1 0 0 0 0 PF03810 PF08389 0 1 0 0 0 0 PF04110 0 0 0 0 1 0 PF04758 0 0 0 0 1 0 PF04840 0 0 1 0 0 0 PF04851 0 1 0 0 0 0 PF05051 0 0 0 0 1 0 PF05154 PF01607 1 0 0 0 0 0 PF05383 PF00076 1 0 1 0 0 0 PF05422 PF16978 0 0 1 0 0 0 PF05485 PF01753 1 0 0 0 0 0 PF05602 PF01326 PF00391 1 0 0 0 0 0 PF05773 PF00270 1 0 2 0 0 0 PF05843 PF00076 1 0 0 0 0 0 PF05902 0 1 0 0 0 0 PF05994 0 1 0 0 0 0 PF06201 PF07690 1 0 0 0 0 0 PF06292 0 1 0 0 0 0 PF06371 PF06367 PF02181 PF06345 0 1 0 0 0 0 PF06472 PF00005 PF12874 PF00096 1 0 0 0 0 0 PF06732 0 0 1 0 0 0 PF07061 0 0 2 0 0 0 PF07159 0 1 0 0 0 0 PF07464 0 0 0 0 1 0 PF07531 0 0 3 0 0 0 PF07648 PF13927 1 0 0 0 0 0 PF07679 PF00008 1 0 0 0 0 0 PF07679 PF13927 PF07679 PF13927 PF07679 PF00041 PF07679 PF00041 1 0 0 0 0 0 PF07713 0 1 0 0 0 0 PF07714 0 1 0 0 0 0 PF07774 0 0 1 0 0 0 PF07776 PF12874 PF13894 PF13912 PF00096 1 0 0 0 0 0 PF07776 PF13912 PF12874 PF13912 PF00096 1 0 0 0 0 0 PF07888 0 0 0 0 1 0 PF07993 PF03015 PF07714 1 0 0 0 0 0 PF07993 PF03015 PF07993 PF03015 1 0 0 0 0 0 PF08169 PF01388 PF11717 PF00443 1 0 0 0 0 0 PF08205 PF04515 1 0 0 0 0 0 PF08212 0 0 0 0 1 0 PF08240 PF01607 1 0 0 0 0 0 PF08241 PF05093 1 0 0 0 0 0 PF08245 0 0 0 0 1 0 PF08385 PF08393 PF12774 0 0 15 0 0 0 PF08416 PF00018 1 0 0 0 0 0 PF08506 PF03378 0 1 0 0 0 0 PF08686 0 0 8 0 0 0 PF08767 0 1 0 0 0 0 PF08880 PF07529 PF07533 PF00176 PF00271 PF14619 0 1 0 0 0 0 PF09340 0 0 0 0 1 0 PF09379 PF00373 PF09380 PF08736 0 1 0 0 0 0 PF09379 PF00373 PF09380 PF13920 1 0 0 0 0 0 PF09596 0 0 0 0 1 0 PF09811 0 0 0 0 1 0 PF10177 0 1 0 0 0 0 PF10178 0 0 0 0 1 0 PF10187 0 0 0 0 1 0 PF10347 PF10351 0 0 1 0 0 0 PF10484 0 0 0 0 1 0 PF10545 PF00076 1 0 0 0 0 0 PF10545 PF02944 PF10545 1 0 0 0 0 0 PF10602 0 1 0 0 0 0 PF11540 0 1 0 0 0 0 PF11904 0 1 0 0 0 0 PF12062 0 1 0 0 0 0 PF12718 PF00261 1 0 0 0 0 0 PF12722 0 0 0 0 1 0 PF12796 0 3 0 0 0 0 PF12796 PF00023 PF00520 1 0 0 0 0 0 PF12796 PF00023 PF01753 1 0 0 0 0 0 PF12796 PF00595 1 0 0 0 0 0 PF12796 PF09631 1 0 0 0 0 0 PF12796 PF13606 PF12796 1 0 0 0 0 0 PF12796 PF13637 PF00520 1 0 0 0 0 0 PF12796 PF15898 1 0 0 0 0 0 PF12799 PF14580 1 0 0 0 0 0 PF12872 0 1 0 0 0 0 PF12874 PF00096 PF13894 1 0 0 0 0 0 PF12874 PF00096 PF13894 PF12874 1 0 0 0 0 0 PF12874 PF03828 1 0 0 0 0 0 PF12877 0 0 0 0 1 0 PF12894 PF12816 1 0 0 0 0 0 PF13017 0 0 1 0 0 0 PF13174 0 0 3 0 0 0 PF13181 PF13374 1 0 0 0 0 0 PF13384 0 0 1 0 0 0 PF13432 PF13181 PF04564 1 0 0 0 0 0 PF13445 PF00643 PF00025 1 0 0 0 0 0 PF13499 PF01794 PF08022 PF08030 0 0 2 0 0 0 PF13516 PF00560 PF13855 1 0 0 0 0 0 PF13516 PF13855 1 0 3 0 0 0 PF13606 PF12796 PF01529 1 0 0 0 0 0 PF13637 PF00788 1 0 0 0 0 0 PF13637 PF12796 PF00023 PF12796 1 0 0 0 0 0 PF13637 PF12796 PF13857 1 0 0 0 0 0 PF13639 PF01436 1 0 0 0 0 0 PF13716 PF00435 PF00621 PF07679 PF00069 1 0 0 0 0 0 PF13833 PF00036 1 0 0 0 0 0 PF13833 PF13499 PF00153 1 0 0 0 0 0 PF13855 PF10545 1 0 0 0 0 0 PF13857 PF12796 PF13637 PF12796 1 0 0 0 0 0 PF13895 PF13927 PF00041 0 0 2 0 0 0 PF13912 PF00096 PF13894 1 0 0 0 0 0 PF13927 PF07679 PF07714 1 0 0 0 0 0 PF13927 PF07679 PF13927 PF07679 PF00041 1 0 0 0 0 0 PF13931 0 1 0 0 0 0 PF13934 0 0 1 0 0 0 PF14050 0 0 2 0 0 0 PF14223 PF00098 1 0 0 0 0 0 PF14580 PF13855 1 0 0 0 0 0 PF14604 PF00018 PF00017 1 0 0 0 0 0 PF14761 PF14762 0 0 1 0 0 0 PF15348 PF00028 1 0 0 0 0 0 PF15410 0 1 5 0 0 0 PF15810 0 0 0 0 1 0 PF15870 PF00929 1 0 0 0 0 0 PF15904 PF13855 PF13516 1 0 0 0 0 0 PF16087 PF00010 1 0 0 0 0 0 PF16187 PF05193 0 1 0 0 0 0 PF16213 PF12783 PF01369 0 0 1 0 0 0 PF16214 0 1 3 0 0 0 PF16470 0 1 0 0 0 0 PF16470 PF00082 1 0 3 0 0 0 PF16486 PF08699 PF02170 0 1 2 0 0 0 PF16488 PF16487 PF02171 0 1 0 0 0 0 PF16565 0 0 1 0 0 0 PF16881 0 0 1 0 0 0 PF17177 0 0 0 0 1 0