GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0017137	Rab GTPase binding	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
GO:0051020	GTPase binding	Gains
GO:0017016	Ras GTPase binding	Gains
GO:0031267	small GTPase binding	Gains
GO:0017160	Ral GTPase binding	Gains
GO:0004035	alkaline phosphatase activity	Gains
GO:0005178	integrin binding	Gains
GO:0008188	neuropeptide receptor activity	Gains
GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	Gains
GO:0016886	ligase activity, forming phosphoric ester bonds	Gains
GO:0017112	Rab guanyl-nucleotide exchange factor activity	Gains
GO:0005524	ATP binding	Gains
GO:0032559	adenyl ribonucleotide binding	Gains
GO:0001653	peptide receptor activity	Gains
GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
GO:0015085	calcium ion transmembrane transporter activity	Gains
GO:0005262	calcium channel activity	Gains
GO:0003824	catalytic activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0004872	receptor activity	Gains
GO:0008233	peptidase activity	Gains
GO:0030554	adenyl nucleotide binding	Gains
GO:0060089	molecular transducer activity	Gains
GO:0061134	peptidase regulator activity	Gains
GO:0015197	peptide transporter activity	Gains
GO:0008528	G-protein coupled peptide receptor activity	Gains
GO:0004040	amidase activity	Gains
GO:0008381	mechanically-gated ion channel activity	Gains
GO:0008177	succinate dehydrogenase (ubiquinone) activity	Gains
GO:0008113	peptide-methionine (S)-S-oxide reductase activity	Gains
GO:0004484	mRNA guanylyltransferase activity	Gains
GO:0022833	mechanically gated channel activity	Gains
GO:0004565	beta-galactosidase activity	Gains
GO:0045159	myosin II binding	Gains
GO:0043168	anion binding	Gains
GO:0032027	myosin light chain binding	Gains
GO:0031208	POZ domain binding	Gains
GO:0016743	carboxyl- or carbamoyltransferase activity	Gains
GO:0008565	protein transporter activity	Gains
GO:0010181	FMN binding	Gains
GO:0008234	cysteine-type peptidase activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Losses
GO:0031078	histone deacetylase activity (H3-K14 specific)	Losses
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)	Losses
GO:0004463	leukotriene-A4 hydrolase activity	Losses
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	Losses
GO:0034739	histone deacetylase activity (H4-K16 specific)	Losses
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	Losses
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)	Losses
GO:0032129	histone deacetylase activity (H3-K9 specific)	Losses
GO:0070001	aspartic-type peptidase activity	Losses
GO:0004190	aspartic-type endopeptidase activity	Losses
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Losses
GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Losses
GO:0017136	NAD-dependent histone deacetylase activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0046872	metal ion binding	Losses
GO:0016803	ether hydrolase activity	Losses
GO:0043169	cation binding	Losses
GO:0034979	NAD-dependent protein deacetylase activity	Losses
GO:0004004	ATP-dependent RNA helicase activity	Losses
GO:0005507	copper ion binding	Losses
GO:0008186	RNA-dependent ATPase activity	Losses
GO:0016801	hydrolase activity, acting on ether bonds	Losses
GO:0004407	histone deacetylase activity	Losses
GO:0004576	oligosaccharyl transferase activity	Losses
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	Losses
GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	Losses
GO:0008073	ornithine decarboxylase inhibitor activity	Losses
GO:0035049	juvenile hormone acid methyltransferase activity	Losses
GO:0019010	farnesoic acid O-methyltransferase activity	Losses
GO:0008908	isochorismatase activity	Losses
GO:0004097	catechol oxidase activity	Losses
GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
GO:0004995	tachykinin receptor activity	Losses
GO:0004950	chemokine receptor activity	Losses
GO:0031005	filamin binding	Losses
GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
GO:0033842	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	Losses
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
GO:0034185	apolipoprotein binding	Losses
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	Losses
GO:0015386	potassium:proton antiporter activity	Losses
GO:0032028	myosin head/neck binding	Losses
GO:0031489	myosin V binding	Losses
GO:0003873	6-phosphofructo-2-kinase activity	Losses
GO:0016900	oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor	Losses
GO:0097109	neuroligin family protein binding	Losses
GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity	Losses
GO:0008531	riboflavin kinase activity	Losses
GO:0036263	L-DOPA monooxygenase activity	Losses
GO:0036264	dopamine monooxygenase activity	Losses
GO:0050111	mycocerosate synthase activity	Losses
GO:0070854	myosin VI heavy chain binding	Losses
GO:0070855	myosin VI head/neck binding	Losses
GO:0042979	ornithine decarboxylase regulator activity	Losses
GO:2001070	starch binding	Losses
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Losses
GO:0003724	RNA helicase activity	Losses
GO:0033558	protein deacetylase activity	Losses
GO:0016651	oxidoreductase activity, acting on NAD(P)H	Losses
GO:0031078	histone deacetylase activity (H3-K14 specific)	Extinctions
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)	Extinctions
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	Extinctions
GO:0034739	histone deacetylase activity (H4-K16 specific)	Extinctions
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	Extinctions
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)	Extinctions
GO:0032129	histone deacetylase activity (H3-K9 specific)	Extinctions
GO:0070001	aspartic-type peptidase activity	Extinctions
GO:0004190	aspartic-type endopeptidase activity	Extinctions
GO:0017136	NAD-dependent histone deacetylase activity	Extinctions
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0005507	copper ion binding	Extinctions
GO:0034979	NAD-dependent protein deacetylase activity	Extinctions
GO:0004407	histone deacetylase activity	Extinctions
GO:0004576	oligosaccharyl transferase activity	Extinctions
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	Extinctions
GO:0016779	nucleotidyltransferase activity	Extinctions
GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	Extinctions
GO:0008073	ornithine decarboxylase inhibitor activity	Extinctions
GO:0008908	isochorismatase activity	Extinctions
GO:0016900	oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor	Extinctions
GO:0008531	riboflavin kinase activity	Extinctions
GO:0042979	ornithine decarboxylase regulator activity	Extinctions
GO:0034061	DNA polymerase activity	Extinctions
GO:0033558	protein deacetylase activity	Extinctions
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Extinctions
GO:0046872	metal ion binding	Extinctions
GO:0019213	deacetylase activity	Extinctions
GO:0043169	cation binding	Extinctions
GO:0015932	nucleobase-containing compound transmembrane transporter activity	Extinctions
GO:1901505	carbohydrate derivative transmembrane transporter activity	Extinctions
GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	Extinctions
GO:0016531	copper chaperone activity	Extinctions
GO:0036080	purine nucleotide-sugar transmembrane transporter activity	Extinctions
GO:0004496	mevalonate kinase activity	Extinctions
GO:0004421	hydroxymethylglutaryl-CoA synthase activity	Extinctions
GO:0005462	UDP-N-acetylglucosamine transmembrane transporter activity	Extinctions
GO:0005464	UDP-xylose transmembrane transporter activity	Extinctions
GO:0005457	GDP-fucose transmembrane transporter activity	Extinctions
GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding	Extinctions
GO:0008834	di-trans,poly-cis-decaprenylcistransferase activity	Extinctions
GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	Extinctions
GO:0008613	diuretic hormone activity	Extinctions
GO:0016757	transferase activity, transferring glycosyl groups	Extinctions
GO:0003954	NADH dehydrogenase activity	Extinctions