GO:0003964 RNA-directed DNA polymerase activity Gains GO:0034061 DNA polymerase activity Gains GO:0140097 catalytic activity, acting on DNA Gains GO:0003676 nucleic acid binding Gains GO:0016779 nucleotidyltransferase activity Gains GO:0005549 odorant binding Gains GO:0070001 aspartic-type peptidase activity Gains GO:0004190 aspartic-type endopeptidase activity Gains GO:0004984 olfactory receptor activity Gains GO:0004518 nuclease activity Gains GO:0008270 zinc ion binding Gains GO:1901363 heterocyclic compound binding Gains GO:0097159 organic cyclic compound binding Gains GO:0046914 transition metal ion binding Gains GO:0004519 endonuclease activity Gains GO:0004175 endopeptidase activity Gains GO:0003723 RNA binding Gains GO:0004523 RNA-DNA hybrid ribonuclease activity Gains GO:0070011 peptidase activity, acting on L-amino acid peptides Gains GO:0008233 peptidase activity Gains GO:0043169 cation binding Gains GO:0046872 metal ion binding Gains GO:0003677 DNA binding Gains GO:0099600 transmembrane receptor activity Gains GO:0016788 hydrolase activity, acting on ester bonds Gains GO:0005488 binding Gains GO:0016772 transferase activity, transferring phosphorus-containing groups Gains GO:0004888 transmembrane signaling receptor activity Gains GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters Gains GO:0004521 endoribonuclease activity Gains GO:0016787 hydrolase activity Gains GO:0038023 signaling receptor activity Gains GO:0004930 G-protein coupled receptor activity Gains GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters Gains GO:0004872 receptor activity Gains GO:0005230 extracellular ligand-gated ion channel activity Gains GO:0003678 DNA helicase activity Gains GO:0022824 transmitter-gated ion channel activity Gains GO:0022835 transmitter-gated channel activity Gains GO:0004970 ionotropic glutamate receptor activity Gains GO:0008236 serine-type peptidase activity Gains GO:0017171 serine hydrolase activity Gains GO:0005234 extracellularly glutamate-gated ion channel activity Gains GO:0060089 molecular transducer activity Gains GO:0005231 excitatory extracellular ligand-gated ion channel activity Gains GO:0022834 ligand-gated channel activity Gains GO:0015276 ligand-gated ion channel activity Gains GO:0008066 glutamate receptor activity Gains GO:0019955 cytokine binding Gains GO:0004871 signal transducer activity Gains GO:0004252 serine-type endopeptidase activity Gains GO:0004540 ribonuclease activity Gains GO:0043140 ATP-dependent 3'-5' DNA helicase activity Gains GO:0043138 3'-5' DNA helicase activity Gains GO:0018492 carbon-monoxide dehydrogenase (acceptor) activity Gains GO:0008422 beta-glucosidase activity Gains GO:0018685 alkane 1-monooxygenase activity Gains GO:0050662 coenzyme binding Gains GO:0008762 UDP-N-acetylmuramate dehydrogenase activity Gains GO:0004803 transposase activity Gains GO:0030594 neurotransmitter receptor activity Gains GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors Gains GO:0050660 flavin adenine dinucleotide binding Gains GO:0016614 oxidoreductase activity, acting on CH-OH group of donors Gains GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity Gains GO:0004972 NMDA glutamate receptor activity Gains GO:0004185 serine-type carboxypeptidase activity Gains GO:0003990 acetylcholinesterase activity Gains GO:0004104 cholinesterase activity Gains GO:0004568 chitinase activity Gains GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Gains GO:0008527 taste receptor activity Gains GO:0001105 RNA polymerase II transcription coactivator activity Gains GO:0070008 serine-type exopeptidase activity Gains GO:0004736 pyruvate carboxylase activity Gains GO:0017110 nucleoside-diphosphatase activity Gains GO:0045134 uridine-diphosphatase activity Gains GO:0004563 beta-N-acetylhexosaminidase activity Gains GO:0008253 5'-nucleotidase activity Gains GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding Gains GO:0022836 gated channel activity Gains GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds Gains GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Gains GO:0050661 NADP binding Gains GO:0050254 rhodopsin kinase activity Losses GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Losses GO:0004983 neuropeptide Y receptor activity Losses GO:0052832 inositol monophosphate 3-phosphatase activity Losses GO:0052833 inositol monophosphate 4-phosphatase activity Losses GO:0052834 inositol monophosphate phosphatase activity Losses GO:0008934 inositol monophosphate 1-phosphatase activity Losses GO:0001637 G-protein coupled chemoattractant receptor activity Losses GO:0004950 chemokine receptor activity Losses GO:0008528 G-protein coupled peptide receptor activity Losses GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Losses GO:0004835 tubulin-tyrosine ligase activity Losses GO:0001653 peptide receptor activity Losses GO:0004896 cytokine receptor activity Losses GO:0008237 metallopeptidase activity Losses GO:0008188 neuropeptide receptor activity Losses GO:0004222 metalloendopeptidase activity Losses GO:0038023 signaling receptor activity Losses GO:0016162 cellulose 1,4-beta-cellobiosidase activity Losses GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding Losses GO:0042578 phosphoric ester hydrolase activity Losses GO:0004165 dodecenoyl-CoA delta-isomerase activity Losses GO:0046872 metal ion binding Losses GO:0043169 cation binding Losses GO:0020037 heme binding Losses GO:0016791 phosphatase activity Losses GO:0046906 tetrapyrrole binding Losses GO:0043177 organic acid binding Losses GO:0031406 carboxylic acid binding Losses GO:0016597 amino acid binding Losses GO:0099600 transmembrane receptor activity Losses GO:0004879 nuclear receptor activity Losses GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding Losses GO:0004888 transmembrane signaling receptor activity Losses GO:1901681 sulfur compound binding Losses GO:0033218 amide binding Losses GO:0003680 AT DNA binding Losses GO:0008579 JUN kinase phosphatase activity Losses GO:0001106 RNA polymerase II transcription corepressor activity Losses GO:0004794 L-threonine ammonia-lyase activity Losses GO:0016841 ammonia-lyase activity Losses GO:0015054 gastrin receptor activity Losses GO:0043295 glutathione binding Losses GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity Losses GO:0001222 transcription corepressor binding Losses GO:0001226 RNA polymerase II transcription corepressor binding Losses GO:0016595 glutamate binding Losses GO:0008658 penicillin binding Losses GO:0046987 N-acetyllactosamine beta-1,3-glucuronosyltransferase activity Losses GO:0046988 asioloorosomucoid beta-1,3-glucuronosyltransferase activity Losses GO:0046989 galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity Losses GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity Losses GO:0019153 protein-disulfide reductase (glutathione) activity Losses GO:0019158 mannokinase activity Losses GO:0097109 neuroligin family protein binding Losses GO:0043560 insulin receptor substrate binding Losses GO:0043559 insulin binding Losses GO:0004634 phosphopyruvate hydratase activity Losses GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity Losses GO:0005043 netrin receptor activity involved in chemorepulsion Losses GO:0005009 insulin-activated receptor activity Losses GO:0051425 PTB domain binding Losses GO:0001642 group III metabotropic glutamate receptor activity Losses GO:0034185 apolipoprotein binding Losses GO:1900750 oligopeptide binding Losses GO:0004020 adenylylsulfate kinase activity Losses GO:0004995 tachykinin receptor activity Losses GO:0071837 HMG box domain binding Losses GO:0070733 protein adenylyltransferase activity Losses GO:0070856 myosin VI light chain binding Losses GO:0004396 hexokinase activity Losses GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Losses GO:0004340 glucokinase activity Losses GO:0005104 fibroblast growth factor receptor binding Losses GO:0030785 [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity Losses GO:0003708 retinoic acid receptor activity Losses GO:0008865 fructokinase activity Losses GO:0098519 nucleotide phosphatase activity, acting on free nucleotides Losses GO:0008881 glutamate racemase activity Losses GO:0016785 transferase activity, transferring selenium-containing groups Losses GO:0071906 CRD domain binding Losses GO:0016773 phosphotransferase activity, alcohol group as acceptor Losses GO:0004872 receptor activity Losses GO:0003700 DNA binding transcription factor activity Losses GO:0044212 transcription regulatory region DNA binding Losses GO:0008235 metalloexopeptidase activity Losses GO:0001067 regulatory region nucleic acid binding Losses GO:0000975 regulatory region DNA binding Losses GO:0060089 molecular transducer activity Losses GO:0016301 kinase activity Losses GO:0140110 transcription regulator activity Losses GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds Losses GO:1901567 fatty acid derivative binding Losses GO:0000062 fatty-acyl-CoA binding Losses GO:0050254 rhodopsin kinase activity Extinctions GO:0004835 tubulin-tyrosine ligase activity Extinctions GO:0016162 cellulose 1,4-beta-cellobiosidase activity Extinctions GO:0004983 neuropeptide Y receptor activity Extinctions GO:0008188 neuropeptide receptor activity Extinctions GO:0043177 organic acid binding Extinctions GO:0031406 carboxylic acid binding Extinctions GO:0016597 amino acid binding Extinctions GO:0042578 phosphoric ester hydrolase activity Extinctions GO:0008528 G-protein coupled peptide receptor activity Extinctions GO:0001653 peptide receptor activity Extinctions GO:0008235 metalloexopeptidase activity Extinctions GO:0046872 metal ion binding Extinctions GO:0016791 phosphatase activity Extinctions GO:0020037 heme binding Extinctions GO:0008579 JUN kinase phosphatase activity Extinctions GO:0004794 L-threonine ammonia-lyase activity Extinctions GO:0016841 ammonia-lyase activity Extinctions GO:0015054 gastrin receptor activity Extinctions GO:0043295 glutathione binding Extinctions GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity Extinctions GO:0016595 glutamate binding Extinctions GO:0008658 penicillin binding Extinctions GO:0046987 N-acetyllactosamine beta-1,3-glucuronosyltransferase activity Extinctions GO:0046988 asioloorosomucoid beta-1,3-glucuronosyltransferase activity Extinctions GO:0046989 galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity Extinctions GO:0019153 protein-disulfide reductase (glutathione) activity Extinctions GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity Extinctions GO:0001642 group III metabotropic glutamate receptor activity Extinctions GO:1900750 oligopeptide binding Extinctions GO:0070733 protein adenylyltransferase activity Extinctions GO:0070856 myosin VI light chain binding Extinctions GO:0005104 fibroblast growth factor receptor binding Extinctions GO:0003708 retinoic acid receptor activity Extinctions GO:0098519 nucleotide phosphatase activity, acting on free nucleotides Extinctions GO:0008881 glutamate racemase activity Extinctions GO:0016785 transferase activity, transferring selenium-containing groups Extinctions GO:0043169 cation binding Extinctions GO:0046906 tetrapyrrole binding Extinctions GO:0016849 phosphorus-oxygen lyase activity Extinctions GO:0008234 cysteine-type peptidase activity Extinctions GO:0004181 metallocarboxypeptidase activity Extinctions