GO:0003676	nucleic acid binding	Gains
GO:0008527	taste receptor activity	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:1901363	heterocyclic compound binding	Gains
GO:0097159	organic cyclic compound binding	Gains
GO:0008270	zinc ion binding	Gains
GO:0004175	endopeptidase activity	Gains
GO:0005549	odorant binding	Gains
GO:0005488	binding	Gains
GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
GO:0008233	peptidase activity	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0046914	transition metal ion binding	Gains
GO:0050780	dopamine receptor binding	Gains
GO:0036132	13-prostaglandin reductase activity	Gains
GO:0031752	D5 dopamine receptor binding	Gains
GO:0043993	histone acetyltransferase activity (H3-K18 specific)	Gains
GO:0008349	MAP kinase kinase kinase kinase activity	Gains
GO:0008412	4-hydroxybenzoate octaprenyltransferase activity	Gains
GO:0047293	4-hydroxybenzoate nonaprenyltransferase activity	Gains
GO:0044017	histone acetyltransferase activity (H3-K27 specific)	Gains
GO:0004324	ferredoxin-NADP+ reductase activity	Gains
GO:0030628	pre-mRNA 3'-splice site binding	Gains
GO:0002094	polyprenyltransferase activity	Gains
GO:0031005	filamin binding	Gains
GO:0002083	4-hydroxybenzoate decaprenyltransferase activity	Gains
GO:0042656	JUN kinase kinase kinase kinase activity	Gains
GO:0047522	15-oxoprostaglandin 13-oxidase activity	Gains
GO:0004168	dolichol kinase activity	Gains
GO:0015459	potassium channel regulator activity	Gains
GO:0004711	ribosomal protein S6 kinase activity	Gains
GO:0004852	uroporphyrinogen-III synthase activity	Gains
GO:0004823	leucine-tRNA ligase activity	Gains
GO:0004046	aminoacylase activity	Gains
GO:0016843	amine-lyase activity	Gains
GO:0016844	strictosidine synthase activity	Gains
GO:0008140	cAMP response element binding protein binding	Gains
GO:0003682	chromatin binding	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0004872	receptor activity	Gains
GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
GO:0008527	taste receptor activity	Losses
GO:0016801	hydrolase activity, acting on ether bonds	Losses
GO:0008329	signaling pattern recognition receptor activity	Losses
GO:0004463	leukotriene-A4 hydrolase activity	Losses
GO:0038187	pattern recognition receptor activity	Losses
GO:0015078	hydrogen ion transmembrane transporter activity	Losses
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
GO:0008081	phosphoric diester hydrolase activity	Losses
GO:0009055	electron transfer activity	Losses
GO:0004312	fatty acid synthase activity	Losses
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0016803	ether hydrolase activity	Losses
GO:0042834	peptidoglycan binding	Losses
GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
GO:0020037	heme binding	Losses
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
GO:0046906	tetrapyrrole binding	Losses
GO:0016298	lipase activity	Losses
GO:0003990	acetylcholinesterase activity	Losses
GO:0008812	choline dehydrogenase activity	Losses
GO:0004104	cholinesterase activity	Losses
GO:0015002	heme-copper terminal oxidase activity	Losses
GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
GO:0004129	cytochrome-c oxidase activity	Losses
GO:0004620	phospholipase activity	Losses
GO:0038023	signaling receptor activity	Losses
GO:0004576	oligosaccharyl transferase activity	Losses
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	Losses
GO:0008121	ubiquinol-cytochrome-c reductase activity	Losses
GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Losses
GO:0099600	transmembrane receptor activity	Losses
GO:0008238	exopeptidase activity	Losses
GO:0060089	molecular transducer activity	Losses
GO:0004888	transmembrane signaling receptor activity	Losses
GO:0004872	receptor activity	Losses
GO:0016019	peptidoglycan receptor activity	Losses
GO:0015250	water channel activity	Losses
GO:0015217	ADP transmembrane transporter activity	Losses
GO:0030366	molybdopterin synthase activity	Losses
GO:0001875	lipopolysaccharide receptor activity	Losses
GO:0008020	G-protein coupled photoreceptor activity	Losses
GO:0003919	FMN adenylyltransferase activity	Losses
GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Losses
GO:0004507	steroid 11-beta-monooxygenase activity	Losses
GO:0003933	GTP cyclohydrolase activity	Losses
GO:0003934	GTP cyclohydrolase I activity	Losses
GO:0052869	arachidonic acid omega-hydroxylase activity	Losses
GO:0052870	tocopherol omega-hydroxylase activity	Losses
GO:0052871	alpha-tocopherol omega-hydroxylase activity	Losses
GO:0072542	protein phosphatase activator activity	Losses
GO:0051011	microtubule minus-end binding	Losses
GO:0008940	nitrate reductase activity	Losses
GO:0004604	phosphoadenylyl-sulfate reductase (thioredoxin) activity	Losses
GO:0046790	virion binding	Losses
GO:0019010	farnesoic acid O-methyltransferase activity	Losses
GO:0034584	piRNA binding	Losses
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Losses
GO:0050051	leukotriene-B4 20-monooxygenase activity	Losses
GO:0004062	aryl sulfotransferase activity	Losses
GO:0004027	alcohol sulfotransferase activity	Losses
GO:0004034	aldose 1-epimerase activity	Losses
GO:0016794	diphosphoric monoester hydrolase activity	Losses
GO:0005372	water transmembrane transporter activity	Losses
GO:0035049	juvenile hormone acid methyltransferase activity	Losses
GO:0005347	ATP transmembrane transporter activity	Losses
GO:0008160	protein tyrosine phosphatase activator activity	Losses
GO:0005471	ATP:ADP antiporter activity	Losses
GO:0042736	NADH kinase activity	Losses
GO:0009703	nitrate reductase (NADH) activity	Losses
GO:0047749	cholestanetriol 26-monooxygenase activity	Losses
GO:0004304	estrone sulfotransferase activity	Losses
GO:0004490	methylglutaconyl-CoA hydratase activity	Losses
GO:0047886	farnesol dehydrogenase activity	Losses
GO:0008728	GTP diphosphokinase activity	Losses
GO:0071885	N-terminal protein N-methyltransferase activity	Losses
GO:0008893	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	Losses
GO:0032500	muramyl dipeptide binding	Losses
GO:0004153	dihydropterin deaminase activity	Losses
GO:0047536	2-aminoadipate transaminase activity	Losses
GO:0051721	protein phosphatase 2A binding	Losses
GO:0004139	deoxyribose-phosphate aldolase activity	Losses
GO:0019211	phosphatase activator activity	Losses
GO:0016491	oxidoreductase activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0005198	structural molecule activity	Losses
GO:0004180	carboxypeptidase activity	Losses
GO:0008010	structural constituent of chitin-based larval cuticle	Losses
GO:0015605	organophosphate ester transmembrane transporter activity	Losses
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	Losses
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Losses
GO:0004497	monooxygenase activity	Losses
GO:0004930	G-protein coupled receptor activity	Losses
GO:0008812	choline dehydrogenase activity	Extinctions
GO:0008527	taste receptor activity	Extinctions
GO:0004576	oligosaccharyl transferase activity	Extinctions
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	Extinctions
GO:0016801	hydrolase activity, acting on ether bonds	Extinctions
GO:0005198	structural molecule activity	Extinctions
GO:0030366	molybdopterin synthase activity	Extinctions
GO:0004507	steroid 11-beta-monooxygenase activity	Extinctions
GO:0003933	GTP cyclohydrolase activity	Extinctions
GO:0003934	GTP cyclohydrolase I activity	Extinctions
GO:0072542	protein phosphatase activator activity	Extinctions
GO:0016794	diphosphoric monoester hydrolase activity	Extinctions
GO:0008160	protein tyrosine phosphatase activator activity	Extinctions
GO:0047749	cholestanetriol 26-monooxygenase activity	Extinctions
GO:0008728	GTP diphosphokinase activity	Extinctions
GO:0071885	N-terminal protein N-methyltransferase activity	Extinctions
GO:0008893	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	Extinctions
GO:0051721	protein phosphatase 2A binding	Extinctions
GO:0004139	deoxyribose-phosphate aldolase activity	Extinctions
GO:0019211	phosphatase activator activity	Extinctions
GO:0004984	olfactory receptor activity	Extinctions
GO:0008890	glycine C-acetyltransferase activity	Extinctions
GO:0005549	odorant binding	Extinctions
GO:0070891	lipoteichoic acid binding	Extinctions
GO:0035299	inositol pentakisphosphate 2-kinase activity	Extinctions
GO:0016453	C-acetyltransferase activity	Extinctions
GO:0001530	lipopolysaccharide binding	Extinctions
GO:0004090	carbonyl reductase (NADPH) activity	Extinctions
GO:0004013	adenosylhomocysteinase activity	Extinctions
GO:0030882	lipid antigen binding	Extinctions
GO:0016802	trialkylsulfonium hydrolase activity	Extinctions
GO:0004462	lactoylglutathione lyase activity	Extinctions
GO:0004463	leukotriene-A4 hydrolase activity	Extinctions
GO:0071855	neuropeptide receptor binding	Extinctions
GO:0019238	cyclohydrolase activity	Extinctions
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Extinctions
GO:0016859	cis-trans isomerase activity	Extinctions
GO:0003823	antigen binding	Extinctions
GO:0003735	structural constituent of ribosome	Extinctions