GO:0004984	olfactory receptor activity	Gains
GO:0005549	odorant binding	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0038023	signaling receptor activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0004872	receptor activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0004312	fatty acid synthase activity	Gains
GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
GO:0030798	trans-aconitate 2-methyltransferase activity	Gains
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0016630	protochlorophyllide reductase activity	Gains
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Gains
GO:0005216	ion channel activity	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0022891	substrate-specific transmembrane transporter activity	Gains
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	Gains
GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Gains
GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Gains
GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Gains
GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Gains
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Gains
GO:0005329	dopamine transmembrane transporter activity	Gains
GO:0015098	molybdate ion transmembrane transporter activity	Gains
GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity	Gains
GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Gains
GO:0004321	fatty-acyl-CoA synthase activity	Gains
GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Gains
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Gains
GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Gains
GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Gains
GO:0050111	mycocerosate synthase activity	Gains
GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Gains
GO:0061542	3-demethylubiquinone-n 3-O-methyltransferase activity	Gains
GO:0015412	ATPase-coupled molybdate transmembrane transporter activity	Gains
GO:0001222	transcription corepressor binding	Gains
GO:0001226	RNA polymerase II transcription corepressor binding	Gains
GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity	Gains
GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity	Gains
GO:0016933	extracellularly glycine-gated ion channel activity	Gains
GO:0015175	neutral amino acid transmembrane transporter activity	Gains
GO:0019811	cocaine binding	Gains
GO:0042943	D-amino acid transmembrane transporter activity	Gains
GO:0015222	serotonin transmembrane transporter activity	Gains
GO:0036401	pyrokinin receptor activity	Gains
GO:0010420	polyprenyldihydroxybenzoate methyltransferase activity	Gains
GO:0008237	metallopeptidase activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0015267	channel activity	Gains
GO:0001012	RNA polymerase II regulatory region DNA binding	Gains
GO:0016408	C-acyltransferase activity	Gains
GO:0015075	ion transmembrane transporter activity	Gains
GO:0005261	cation channel activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0022857	transmembrane transporter activity	Gains
GO:0016615	malate dehydrogenase activity	Losses
GO:0030060	L-malate dehydrogenase activity	Losses
GO:0004190	aspartic-type endopeptidase activity	Losses
GO:0070001	aspartic-type peptidase activity	Losses
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	Losses
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0005272	sodium channel activity	Losses
GO:0051766	inositol trisphosphate kinase activity	Losses
GO:0015081	sodium ion transmembrane transporter activity	Losses
GO:0004104	cholinesterase activity	Losses
GO:0003990	acetylcholinesterase activity	Losses
GO:0022857	transmembrane transporter activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
GO:0005215	transporter activity	Losses
GO:0022892	substrate-specific transporter activity	Losses
GO:0140097	catalytic activity, acting on DNA	Losses
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
GO:0022891	substrate-specific transmembrane transporter activity	Losses
GO:0042165	neurotransmitter binding	Losses
GO:0042166	acetylcholine binding	Losses
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Losses
GO:0005324	long-chain fatty acid transporter activity	Losses
GO:0005347	ATP transmembrane transporter activity	Losses
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Losses
GO:0005471	ATP:ADP antiporter activity	Losses
GO:0000095	S-adenosyl-L-methionine transmembrane transporter activity	Losses
GO:0009703	nitrate reductase (NADH) activity	Losses
GO:0047747	cholate-CoA ligase activity	Losses
GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Losses
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Losses
GO:0035368	selenocysteine insertion sequence binding	Losses
GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Losses
GO:0015217	ADP transmembrane transporter activity	Losses
GO:0015245	fatty acid transporter activity	Losses
GO:0008940	nitrate reductase activity	Losses
GO:0036263	L-DOPA monooxygenase activity	Losses
GO:0036264	dopamine monooxygenase activity	Losses
GO:0004097	catechol oxidase activity	Losses
GO:0004983	neuropeptide Y receptor activity	Losses
GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
GO:0008514	organic anion transmembrane transporter activity	Losses
GO:0015075	ion transmembrane transporter activity	Losses
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
GO:0015501	glutamate:sodium symporter activity	Losses
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Losses
GO:0004033	aldo-keto reductase (NADP) activity	Losses
GO:0005346	purine ribonucleotide transmembrane transporter activity	Losses
GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Losses
GO:0008106	alcohol dehydrogenase (NADP+) activity	Losses
GO:0070405	ammonium ion binding	Losses
GO:0005212	structural constituent of eye lens	Losses
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	Losses
GO:0015301	anion:anion antiporter activity	Losses
GO:0004711	ribosomal protein S6 kinase activity	Losses
GO:0015183	L-aspartate transmembrane transporter activity	Losses
GO:0050833	pyruvate transmembrane transporter activity	Losses
GO:0052723	inositol hexakisphosphate 1-kinase activity	Losses
GO:0052724	inositol hexakisphosphate 3-kinase activity	Losses
GO:0000295	adenine nucleotide transmembrane transporter activity	Losses
GO:0015215	nucleotide transmembrane transporter activity	Losses
GO:0015216	purine nucleotide transmembrane transporter activity	Losses
GO:0003913	DNA photolyase activity	Losses
GO:0004503	monophenol monooxygenase activity	Losses
GO:0003904	deoxyribodipyrimidine photo-lyase activity	Losses
GO:0017040	ceramidase activity	Losses
GO:0000828	inositol hexakisphosphate kinase activity	Losses
GO:0000832	inositol hexakisphosphate 5-kinase activity	Losses
GO:0015002	heme-copper terminal oxidase activity	Losses
GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
GO:0004129	cytochrome-c oxidase activity	Losses
GO:0003700	DNA binding transcription factor activity	Losses
GO:0003730	mRNA 3'-UTR binding	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0048027	mRNA 5'-UTR binding	Losses
GO:0047429	nucleoside-triphosphate diphosphatase activity	Losses
GO:0004013	adenosylhomocysteinase activity	Losses
GO:0008453	alanine-glyoxylate transaminase activity	Losses
GO:0005416	cation:amino acid symporter activity	Losses
GO:0051185	coenzyme transporter activity	Losses
GO:0016802	trialkylsulfonium hydrolase activity	Losses
GO:0017153	sodium:dicarboxylate symporter activity	Losses
GO:0004379	glycylpeptide N-tetradecanoyltransferase activity	Losses
GO:0005283	sodium:amino acid symporter activity	Losses
GO:0019107	myristoyltransferase activity	Losses
GO:0001103	RNA polymerase II repressing transcription factor binding	Losses
GO:0004813	alanine-tRNA ligase activity	Losses
GO:0035613	RNA stem-loop binding	Losses
GO:0004930	G-protein coupled receptor activity	Losses
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Losses
GO:0005216	ion channel activity	Losses
GO:0005272	sodium channel activity	Extinctions
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	Extinctions
GO:0051766	inositol trisphosphate kinase activity	Extinctions
GO:0016615	malate dehydrogenase activity	Extinctions
GO:0004104	cholinesterase activity	Extinctions
GO:0003990	acetylcholinesterase activity	Extinctions
GO:0004983	neuropeptide Y receptor activity	Extinctions
GO:0015081	sodium ion transmembrane transporter activity	Extinctions
GO:0004930	G-protein coupled receptor activity	Extinctions
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Extinctions
GO:0035368	selenocysteine insertion sequence binding	Extinctions
GO:0015002	heme-copper terminal oxidase activity	Extinctions
GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
GO:0004129	cytochrome-c oxidase activity	Extinctions
GO:0052723	inositol hexakisphosphate 1-kinase activity	Extinctions
GO:0052724	inositol hexakisphosphate 3-kinase activity	Extinctions
GO:0003913	DNA photolyase activity	Extinctions
GO:0003904	deoxyribodipyrimidine photo-lyase activity	Extinctions
GO:0017040	ceramidase activity	Extinctions
GO:0000828	inositol hexakisphosphate kinase activity	Extinctions
GO:0000832	inositol hexakisphosphate 5-kinase activity	Extinctions
GO:0004888	transmembrane signaling receptor activity	Extinctions
GO:0008188	neuropeptide receptor activity	Extinctions
GO:0047429	nucleoside-triphosphate diphosphatase activity	Extinctions
GO:0004013	adenosylhomocysteinase activity	Extinctions
GO:0008453	alanine-glyoxylate transaminase activity	Extinctions
GO:0016802	trialkylsulfonium hydrolase activity	Extinctions
GO:0004813	alanine-tRNA ligase activity	Extinctions
GO:0035613	RNA stem-loop binding	Extinctions
GO:0099600	transmembrane receptor activity	Extinctions
GO:0022857	transmembrane transporter activity	Extinctions
GO:0022890	inorganic cation transmembrane transporter activity	Extinctions
GO:0008528	G-protein coupled peptide receptor activity	Extinctions
GO:0030060	L-malate dehydrogenase activity	Extinctions
GO:0005216	ion channel activity	Extinctions
GO:0022838	substrate-specific channel activity	Extinctions
GO:0038023	signaling receptor activity	Extinctions
GO:0001653	peptide receptor activity	Extinctions
GO:0005261	cation channel activity	Extinctions
GO:0022803	passive transmembrane transporter activity	Extinctions
GO:0015267	channel activity	Extinctions
GO:0022891	substrate-specific transmembrane transporter activity	Extinctions