GO:0003964 RNA-directed DNA polymerase activity Gains GO:0034061 DNA polymerase activity Gains GO:0140097 catalytic activity, acting on DNA Gains GO:0016779 nucleotidyltransferase activity Gains GO:0008270 zinc ion binding Gains GO:0046914 transition metal ion binding Gains GO:0004190 aspartic-type endopeptidase activity Gains GO:0070001 aspartic-type peptidase activity Gains GO:0003676 nucleic acid binding Gains GO:0016772 transferase activity, transferring phosphorus-containing groups Gains GO:0004523 RNA-DNA hybrid ribonuclease activity Gains GO:0004519 endonuclease activity Gains GO:0046872 metal ion binding Gains GO:0043169 cation binding Gains GO:0004518 nuclease activity Gains GO:0097159 organic cyclic compound binding Gains GO:1901363 heterocyclic compound binding Gains GO:0003677 DNA binding Gains GO:0005488 binding Gains GO:0003723 RNA binding Gains GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters Gains GO:0015370 solute:sodium symporter activity Gains GO:0022836 gated channel activity Gains GO:0008234 cysteine-type peptidase activity Gains GO:0035197 siRNA binding Gains GO:0047134 protein-disulfide reductase activity Gains GO:0035586 purinergic receptor activity Gains GO:0004803 transposase activity Gains GO:0017112 Rab guanyl-nucleotide exchange factor activity Gains GO:0022838 substrate-specific channel activity Gains GO:0003777 microtubule motor activity Gains GO:0015267 channel activity Gains GO:0022803 passive transmembrane transporter activity Gains GO:0022832 voltage-gated channel activity Gains GO:0005244 voltage-gated ion channel activity Gains GO:0051020 GTPase binding Gains GO:0070011 peptidase activity, acting on L-amino acid peptides Gains GO:0015294 solute:cation symporter activity Gains GO:0005216 ion channel activity Gains GO:0005509 calcium ion binding Gains GO:0015291 secondary active transmembrane transporter activity Gains GO:0003725 double-stranded RNA binding Gains GO:0008233 peptidase activity Gains GO:0015293 symporter activity Gains GO:0005096 GTPase activator activity Gains GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters Gains GO:0005085 guanyl-nucleotide exchange factor activity Gains GO:0016740 transferase activity Gains GO:0005328 neurotransmitter:sodium symporter activity Gains GO:0031267 small GTPase binding Gains GO:0016849 phosphorus-oxygen lyase activity Gains GO:0017137 Rab GTPase binding Gains GO:0043167 ion binding Gains GO:0015171 amino acid transmembrane transporter activity Gains GO:0005088 Ras guanyl-nucleotide exchange factor activity Gains GO:0019825 oxygen binding Gains GO:0004016 adenylate cyclase activity Gains GO:0005253 anion channel activity Gains GO:0004521 endoribonuclease activity Gains GO:0042302 structural constituent of cuticle Gains GO:0030429 kynureninase activity Gains GO:0016906 sterol 3-beta-glucosyltransferase activity Gains GO:0070548 L-glutamine aminotransferase activity Gains GO:0003689 DNA clamp loader activity Gains GO:0005212 structural constituent of eye lens Gains GO:0016781 phosphotransferase activity, paired acceptors Gains GO:0043546 molybdopterin cofactor binding Gains GO:0016882 cyclo-ligase activity Gains GO:0004837 tyrosine decarboxylase activity Gains GO:0001729 ceramide kinase activity Gains GO:0033170 protein-DNA loading ATPase activity Gains GO:0016502 nucleotide receptor activity Gains GO:0004689 phosphorylase kinase activity Gains GO:0008011 structural constituent of pupal chitin-based cuticle Gains GO:0001614 purinergic nucleotide receptor activity Gains GO:0004019 adenylosuccinate synthase activity Gains GO:0031386 protein tag Gains GO:0060089 molecular transducer activity Losses GO:0099600 transmembrane receptor activity Losses GO:0004872 receptor activity Losses GO:0004888 transmembrane signaling receptor activity Losses GO:0004871 signal transducer activity Losses GO:0038023 signaling receptor activity Losses GO:0005549 odorant binding Losses GO:0004930 G-protein coupled receptor activity Losses GO:0003990 acetylcholinesterase activity Losses GO:0004104 cholinesterase activity Losses GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Losses GO:0008527 taste receptor activity Losses GO:0043225 ATPase-coupled anion transmembrane transporter activity Losses GO:0061783 peptidoglycan muralytic activity Losses GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Losses GO:0003858 3-hydroxybutyrate dehydrogenase activity Losses GO:0050062 long-chain-fatty-acyl-CoA reductase activity Losses GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity Losses GO:0015408 ferric-transporting ATPase activity Losses GO:0008484 sulfuric ester hydrolase activity Losses GO:0003796 lysozyme activity Losses GO:0072510 trivalent inorganic cation transmembrane transporter activity Losses GO:0015091 ferric iron transmembrane transporter activity Losses GO:0015605 organophosphate ester transmembrane transporter activity Losses GO:0008066 glutamate receptor activity Losses GO:0004620 phospholipase activity Losses GO:0004857 enzyme inhibitor activity Losses GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Losses GO:0015416 ATPase-coupled organic phosphonate transmembrane transporter activity Losses GO:0005381 iron ion transmembrane transporter activity Losses GO:0015604 organic phosphonate transmembrane transporter activity Losses GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives Losses GO:0016829 lyase activity Losses GO:0008081 phosphoric diester hydrolase activity Losses GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity Losses GO:0052739 phosphatidylserine 1-acylhydrolase activity Losses GO:0004745 retinol dehydrogenase activity Losses GO:0016842 amidine-lyase activity Losses GO:0003978 UDP-glucose 4-epimerase activity Losses GO:0008970 phosphatidylcholine 1-acylhydrolase activity Losses GO:0016298 lipase activity Losses GO:0005201 extracellular matrix structural constituent Losses GO:0030414 peptidase inhibitor activity Losses GO:0008509 anion transmembrane transporter activity Losses GO:0016840 carbon-nitrogen lyase activity Losses GO:0032561 guanyl ribonucleotide binding Losses GO:0019001 guanyl nucleotide binding Losses GO:0008329 signaling pattern recognition receptor activity Losses GO:0003896 DNA primase activity Losses GO:0005251 delayed rectifier potassium channel activity Losses GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed Losses GO:0038187 pattern recognition receptor activity Losses GO:0005525 GTP binding Losses GO:0032550 purine ribonucleoside binding Losses GO:0001883 purine nucleoside binding Losses GO:0004000 adenosine deaminase activity Losses GO:0022857 transmembrane transporter activity Losses GO:0016787 hydrolase activity Losses GO:0004767 sphingomyelin phosphodiesterase activity Losses GO:0061134 peptidase regulator activity Losses GO:0005215 transporter activity Losses GO:0032549 ribonucleoside binding Losses GO:0019239 deaminase activity Losses GO:0042578 phosphoric ester hydrolase activity Losses GO:0030247 polysaccharide binding Losses GO:0016854 racemase and epimerase activity Losses GO:0015926 glucosidase activity Losses GO:0001871 pattern binding Losses GO:0001882 nucleoside binding Losses GO:0008061 chitin binding Losses GO:0015276 ligand-gated ion channel activity Losses GO:0022834 ligand-gated channel activity Losses GO:0052689 carboxylic ester hydrolase activity Losses GO:0022891 substrate-specific transmembrane transporter activity Losses GO:0005216 ion channel activity Losses GO:0022838 substrate-specific channel activity Losses GO:0042834 peptidoglycan binding Losses GO:0005544 calcium-dependent phospholipid binding Losses GO:0042169 SH2 domain binding Losses GO:0004965 G-protein coupled GABA receptor activity Losses GO:0015075 ion transmembrane transporter activity Losses GO:0005549 odorant binding Extinctions GO:0008527 taste receptor activity Extinctions GO:0099600 transmembrane receptor activity Extinctions GO:0004888 transmembrane signaling receptor activity Extinctions GO:0004930 G-protein coupled receptor activity Extinctions GO:0038023 signaling receptor activity Extinctions GO:0004871 signal transducer activity Extinctions GO:0043225 ATPase-coupled anion transmembrane transporter activity Extinctions GO:0008066 glutamate receptor activity Extinctions GO:0008081 phosphoric diester hydrolase activity Extinctions GO:0003896 DNA primase activity Extinctions GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed Extinctions GO:0004857 enzyme inhibitor activity Extinctions GO:0004872 receptor activity Extinctions GO:0015408 ferric-transporting ATPase activity Extinctions GO:0008484 sulfuric ester hydrolase activity Extinctions GO:0003796 lysozyme activity Extinctions GO:0072510 trivalent inorganic cation transmembrane transporter activity Extinctions GO:0015091 ferric iron transmembrane transporter activity Extinctions GO:0008061 chitin binding Extinctions GO:0005201 extracellular matrix structural constituent Extinctions GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Extinctions GO:0036081 extracellular ammonia-gated ion channel activity Extinctions GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Extinctions GO:0042578 phosphoric ester hydrolase activity Extinctions GO:0060089 molecular transducer activity Extinctions GO:0030414 peptidase inhibitor activity Extinctions GO:0015412 ATPase-coupled molybdate transmembrane transporter activity Extinctions GO:0015438 teichoic-acid-transporting ATPase activity Extinctions GO:0005007 fibroblast growth factor-activated receptor activity Extinctions GO:0050897 cobalt ion binding Extinctions GO:0015162 teichoic acid transmembrane transporter activity Extinctions GO:0019797 procollagen-proline 3-dioxygenase activity Extinctions GO:0008496 mannan endo-1,6-alpha-mannosidase activity Extinctions GO:0008428 ribonuclease inhibitor activity Extinctions GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity Extinctions GO:0008191 metalloendopeptidase inhibitor activity Extinctions GO:0018580 nitronate monooxygenase activity Extinctions GO:0003720 telomerase activity Extinctions GO:0003721 telomerase RNA reverse transcriptase activity Extinctions GO:0004423 iduronate-2-sulfatase activity Extinctions GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity Extinctions GO:0008226 tyramine receptor activity Extinctions GO:0033981 D-dopachrome decarboxylase activity Extinctions GO:0098988 G-protein coupled glutamate receptor activity Extinctions GO:0033971 hydroxyisourate hydrolase activity Extinctions GO:0008728 GTP diphosphokinase activity Extinctions GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Extinctions GO:0000156 phosphorelay response regulator activity Extinctions GO:0031544 peptidyl-proline 3-dioxygenase activity Extinctions GO:0008815 citrate (pro-3S)-lyase activity Extinctions GO:0008816 citryl-CoA lyase activity Extinctions GO:0008817 cob(I)yrinic acid a,c-diamide adenosyltransferase activity Extinctions GO:0016794 diphosphoric monoester hydrolase activity Extinctions GO:0004769 steroid delta-isomerase activity Extinctions GO:0042979 ornithine decarboxylase regulator activity Extinctions GO:0017159 pantetheine hydrolase activity Extinctions GO:0015098 molybdate ion transmembrane transporter activity Extinctions GO:0005550 pheromone binding Extinctions GO:0003941 L-serine ammonia-lyase activity Extinctions GO:0032542 sulfiredoxin activity Extinctions GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity Extinctions GO:0045552 dihydrokaempferol 4-reductase activity Extinctions GO:0008073 ornithine decarboxylase inhibitor activity Extinctions GO:0033780 taurochenodeoxycholate 6alpha-hydroxylase activity Extinctions GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity Extinctions GO:0001641 group II metabotropic glutamate receptor activity Extinctions GO:0004056 argininosuccinate lyase activity Extinctions GO:0004038 allantoinase activity Extinctions GO:0015416 ATPase-coupled organic phosphonate transmembrane transporter activity Extinctions GO:1990939 ATP-dependent microtubule motor activity Extinctions GO:0030165 PDZ domain binding Extinctions GO:0005381 iron ion transmembrane transporter activity Extinctions GO:0015604 organic phosphonate transmembrane transporter activity Extinctions