GO:0003964 RNA-directed DNA polymerase activity Gains GO:0034061 DNA polymerase activity Gains GO:0016779 nucleotidyltransferase activity Gains GO:0005244 voltage-gated ion channel activity Gains GO:0022832 voltage-gated channel activity Gains GO:0022843 voltage-gated cation channel activity Gains GO:0008528 G-protein coupled peptide receptor activity Gains GO:0099600 transmembrane receptor activity Gains GO:0001653 peptide receptor activity Gains GO:0005249 voltage-gated potassium channel activity Gains GO:0022836 gated channel activity Gains GO:0140097 catalytic activity, acting on DNA Gains GO:0004872 receptor activity Gains GO:0060089 molecular transducer activity Gains GO:0038023 signaling receptor activity Gains GO:0004803 transposase activity Gains GO:0004930 G-protein coupled receptor activity Gains GO:0004190 aspartic-type endopeptidase activity Gains GO:0070001 aspartic-type peptidase activity Gains GO:0004871 signal transducer activity Gains GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen Gains GO:0004887 thyroid hormone receptor activity Gains GO:0016772 transferase activity, transferring phosphorus-containing groups Gains GO:0015079 potassium ion transmembrane transporter activity Gains GO:0005216 ion channel activity Gains GO:0004888 transmembrane signaling receptor activity Gains GO:0003676 nucleic acid binding Gains GO:0022838 substrate-specific channel activity Gains GO:0005261 cation channel activity Gains GO:0005267 potassium channel activity Gains GO:0022803 passive transmembrane transporter activity Gains GO:0015267 channel activity Gains GO:0018685 alkane 1-monooxygenase activity Gains GO:0008188 neuropeptide receptor activity Gains GO:0004935 adrenergic receptor activity Gains GO:0004977 melanocortin receptor activity Gains GO:0003677 DNA binding Gains GO:0015368 calcium:cation antiporter activity Gains GO:0016740 transferase activity Gains GO:0008010 structural constituent of chitin-based larval cuticle Gains GO:0015077 monovalent inorganic cation transmembrane transporter activity Gains GO:0046873 metal ion transmembrane transporter activity Gains GO:0003723 RNA binding Gains GO:0015035 protein disulfide oxidoreductase activity Gains GO:0020037 heme binding Gains GO:0003700 DNA binding transcription factor activity Gains GO:0015075 ion transmembrane transporter activity Gains GO:0046906 tetrapyrrole binding Gains GO:0070330 aromatase activity Gains GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Gains GO:1901363 heterocyclic compound binding Gains GO:0097159 organic cyclic compound binding Gains GO:0005549 odorant binding Losses GO:0004984 olfactory receptor activity Losses GO:0005119 smoothened binding Losses GO:0004857 enzyme inhibitor activity Losses GO:0030414 peptidase inhibitor activity Losses GO:0061134 peptidase regulator activity Losses GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor Losses GO:0016805 dipeptidase activity Losses GO:0005200 structural constituent of cytoskeleton Losses GO:0008239 dipeptidyl-peptidase activity Losses GO:0001664 G-protein coupled receptor binding Losses GO:0038023 signaling receptor activity Losses GO:0004930 G-protein coupled receptor activity Losses GO:0005484 SNAP receptor activity Losses GO:0030145 manganese ion binding Losses GO:0048018 receptor ligand activity Losses GO:0004866 endopeptidase inhibitor activity Losses GO:0004888 transmembrane signaling receptor activity Losses GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity Losses GO:0004343 glucosamine 6-phosphate N-acetyltransferase activity Losses GO:0016672 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor Losses GO:0016648 oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor Losses GO:0004734 pyrimidodiazepine synthase activity Losses GO:0047886 farnesol dehydrogenase activity Losses GO:0045174 glutathione dehydrogenase (ascorbate) activity Losses GO:0033897 ribonuclease T2 activity Losses GO:0016209 antioxidant activity Losses GO:0061135 endopeptidase regulator activity Losses GO:0008010 structural constituent of chitin-based larval cuticle Losses GO:0008061 chitin binding Losses GO:0030545 receptor regulator activity Losses GO:0099600 transmembrane receptor activity Losses GO:0005198 structural molecule activity Losses GO:0042302 structural constituent of cuticle Losses GO:0022857 transmembrane transporter activity Losses GO:0043492 ATPase activity, coupled to movement of substances Losses GO:0042626 ATPase activity, coupled to transmembrane movement of substances Losses GO:0005214 structural constituent of chitin-based cuticle Losses GO:0004867 serine-type endopeptidase inhibitor activity Losses GO:0046423 allene-oxide cyclase activity Losses GO:0005113 patched binding Losses GO:0015088 copper uptake transmembrane transporter activity Losses GO:0008273 calcium, potassium:sodium antiporter activity Losses GO:0015037 peptide disulfide oxidoreductase activity Losses GO:0015038 glutathione disulfide oxidoreductase activity Losses GO:0005243 gap junction channel activity Losses GO:0047396 glycosylphosphatidylinositol diacylglycerol-lyase activity Losses GO:0050824 water binding Losses GO:0050825 ice binding Losses GO:0019788 NEDD8 transferase activity Losses GO:0070594 juvenile hormone response element binding Losses GO:0008011 structural constituent of pupal chitin-based cuticle Losses GO:0008379 thioredoxin peroxidase activity Losses GO:0004872 receptor activity Losses GO:0005119 smoothened binding Extinctions GO:0005549 odorant binding Extinctions GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor Extinctions GO:0004984 olfactory receptor activity Extinctions GO:0001664 G-protein coupled receptor binding Extinctions GO:0005484 SNAP receptor activity Extinctions GO:0048018 receptor ligand activity Extinctions GO:0004857 enzyme inhibitor activity Extinctions GO:0030145 manganese ion binding Extinctions GO:0030545 receptor regulator activity Extinctions GO:0004343 glucosamine 6-phosphate N-acetyltransferase activity Extinctions GO:0033897 ribonuclease T2 activity Extinctions GO:0030414 peptidase inhibitor activity Extinctions GO:0061134 peptidase regulator activity Extinctions GO:0022890 inorganic cation transmembrane transporter activity Extinctions GO:0000149 SNARE binding Extinctions GO:0005113 patched binding Extinctions GO:0015088 copper uptake transmembrane transporter activity Extinctions GO:0004812 aminoacyl-tRNA ligase activity Extinctions GO:0019901 protein kinase binding Extinctions GO:0004040 amidase activity Extinctions GO:0004989 octopamine receptor activity Extinctions GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity Extinctions GO:0004827 proline-tRNA ligase activity Extinctions GO:0004831 tyrosine-tRNA ligase activity Extinctions GO:0043754 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity Extinctions GO:0005102 receptor binding Extinctions