Domain arrangement Fusions Fissions Terminal losses Terminal emergences Single domain losses Single domain emergences PF00001 PF00153 1 0 0 0 0 0 PF00001 PF07004 1 0 0 0 0 0 PF00004 PF05158 1 0 0 0 0 0 PF00004 PF05875 1 0 0 0 0 0 PF00004 PF09336 0 1 0 0 0 0 PF00005 PF01061 PF00005 PF01061 1 0 0 0 0 0 PF00008 PF07645 PF00008 0 0 2 0 0 0 PF00009 PF03144 PF14492 0 0 2 0 0 0 PF00010 PF07527 PF13774 PF00957 1 0 0 0 0 0 PF00010 PF07527 PF13868 1 0 0 0 0 0 PF00013 PF01607 1 0 0 0 0 0 PF00018 PF00017 PF00018 1 0 0 0 0 0 PF00023 PF12796 1 0 0 0 0 0 PF00027 PF00069 PF00027 PF00069 1 0 0 0 0 0 PF00028 PF00059 1 0 0 0 0 0 PF00035 PF16482 PF05018 1 0 0 0 0 0 PF00043 0 1 0 0 0 0 PF00046 PF12697 1 0 0 0 0 0 PF00056 PF02866 PF10058 1 0 0 0 0 0 PF00057 PF00084 1 0 0 0 0 0 PF00061 PF05826 1 0 0 0 0 0 PF00069 PF00063 1 0 0 0 0 0 PF00069 PF15990 1 0 0 0 0 0 PF00071 PF07690 1 0 0 0 0 0 PF00071 PF13091 1 0 0 0 0 0 PF00076 PF00646 1 0 0 0 0 0 PF00083 0 1 0 0 0 0 PF00083 PF00090 1 0 0 0 0 0 PF00083 PF15275 1 0 0 0 0 0 PF00085 0 1 0 0 0 0 PF00085 PF00171 1 0 0 0 0 0 PF00085 PF13894 PF13912 1 0 0 0 0 0 PF00090 PF00791 PF17217 PF00531 0 1 0 0 0 0 PF00096 PF00098 1 0 0 0 0 0 PF00096 PF12874 PF13894 PF00096 1 0 0 0 0 0 PF00096 PF13912 PF13894 1 0 0 0 0 0 PF00097 PF00018 PF14604 1 0 0 0 0 0 PF00097 PF00643 PF01436 1 0 0 0 0 0 PF00106 PF00083 1 0 0 0 0 0 PF00109 PF02801 PF16197 PF00698 PF14765 PF00107 PF08659 PF00550 0 0 1 0 0 0 PF00120 0 0 1 0 0 0 PF00125 0 1 0 0 0 0 PF00125 PF00538 1 0 0 0 0 0 PF00128 0 1 0 0 0 0 PF00155 PF00046 1 0 0 0 0 0 PF00155 PF00466 PF00428 1 0 0 0 0 0 PF00210 PF00069 1 0 0 0 0 0 PF00225 PF00339 PF02752 1 0 0 0 0 0 PF00240 PF13445 1 0 0 0 0 0 PF00246 PF13620 PF00246 PF13620 PF00246 PF13620 1 0 0 0 0 0 PF00249 0 1 0 0 0 0 PF00270 PF00271 PF00567 1 0 0 0 0 0 PF00270 PF00271 PF12640 1 0 0 0 0 0 PF00307 PF00596 1 0 0 0 0 0 PF00361 0 0 0 0 1 0 PF00370 PF02782 PF00171 1 0 0 0 0 0 PF00373 PF09380 PF00769 0 0 1 0 0 0 PF00373 PF09380 PF13920 1 0 0 0 0 0 PF00412 PF07714 1 0 0 0 0 0 PF00415 PF00651 PF07707 1 0 0 0 0 0 PF00431 PF00390 PF03949 1 0 0 0 0 0 PF00483 PF02020 1 0 0 0 0 0 PF00490 PF00012 1 0 0 0 0 0 PF00501 PF13193 PF00550 1 0 0 0 0 0 PF00505 PF12265 PF00400 1 0 0 0 0 0 PF00520 0 1 0 0 0 0 PF00536 PF02221 1 0 0 0 0 0 PF00561 PF00996 1 0 0 0 0 0 PF00568 PF02205 1 0 0 0 0 0 PF00569 0 1 9 0 0 0 PF00575 0 1 0 0 0 0 PF00581 PF01161 1 0 0 0 0 0 PF00595 PF01369 PF15410 1 0 0 0 0 0 PF00612 PF00004 1 0 0 0 0 0 PF00615 PF08833 PF00778 PF00916 PF01740 1 0 0 0 0 0 PF00621 PF14604 1 0 0 0 0 0 PF00651 PF00096 PF12874 1 0 0 0 0 0 PF00651 PF13894 PF12874 1 0 0 0 0 0 PF00665 PF13927 PF07679 1 0 0 0 0 0 PF00687 PF00076 1 0 0 0 0 0 PF00690 PF00122 PF13246 PF00689 PF01607 1 0 0 0 0 0 PF00701 PF09774 1 0 0 0 0 0 PF00704 PF03167 1 0 0 0 0 0 PF00752 PF00867 PF01607 1 0 0 0 0 0 PF00753 PF02177 PF12924 PF12925 PF10515 1 0 0 0 0 0 PF00764 0 0 0 0 1 0 PF00781 PF00609 0 0 5 0 0 0 PF00831 0 0 0 0 1 0 PF00856 PF00270 PF00271 1 0 0 0 0 0 PF00867 0 0 1 0 0 0 PF00916 PF01740 PF06645 1 0 0 0 0 0 PF00957 PF01776 1 0 0 0 0 0 PF01105 PF00887 1 0 0 0 0 0 PF01125 0 0 0 0 1 0 PF01131 PF01396 PF06839 0 0 1 0 0 0 PF01145 PF00153 1 0 0 0 0 0 PF01146 PF02771 PF02770 PF00441 1 0 0 0 0 0 PF01208 PF01553 PF16076 1 0 0 0 0 0 PF01237 PF04201 1 0 0 0 0 0 PF01244 PF05649 PF01431 1 0 0 0 0 0 PF01263 PF00168 PF00616 PF00169 PF00779 1 0 0 0 0 0 PF01287 0 0 0 0 1 0 PF01302 PF14580 1 0 0 0 0 0 PF01388 PF01803 1 0 0 0 0 0 PF01391 0 1 0 0 0 0 PF01398 PF14604 PF00787 PF10456 1 0 0 0 0 0 PF01470 0 0 0 0 1 0 PF01472 PF01253 1 0 0 0 0 0 PF01553 PF00254 1 0 0 0 0 0 PF01582 PF01607 1 0 0 0 0 0 PF01607 PF00089 1 0 0 0 0 0 PF01813 PF00583 1 0 0 0 0 0 PF01926 PF00406 1 0 0 0 0 0 PF02104 0 0 0 0 1 0 PF02123 0 0 0 0 0 1 PF02210 PF01034 1 0 0 0 0 0 PF02214 PF00520 PF11879 1 0 0 0 0 0 PF02389 PF06859 1 0 0 0 0 0 PF02460 PF00135 1 0 0 0 0 0 PF02493 PF07264 1 0 0 0 0 0 PF02759 PF00640 1 0 0 0 0 0 PF02786 PF02785 PF00364 0 0 1 0 0 0 PF02798 0 1 3 0 0 0 PF02806 0 1 0 0 0 0 PF02949 PF00474 1 0 0 0 0 0 PF02949 PF01180 1 0 0 0 0 0 PF02949 PF07690 1 0 0 0 0 0 PF02958 PF08534 1 0 0 0 0 0 PF03015 PF07686 1 0 0 0 0 0 PF03098 PF05478 1 0 0 0 0 0 PF03121 0 0 0 0 1 0 PF03261 0 0 0 0 1 0 PF03266 0 0 0 0 1 0 PF03311 PF03483 PF03484 1 0 0 0 0 0 PF03392 PF00047 PF13927 PF07679 1 0 0 0 0 0 PF03645 PF00328 1 0 0 0 0 0 PF03647 PF02784 PF00278 1 0 0 0 0 0 PF03671 0 0 0 0 1 0 PF03731 PF02735 PF03730 PF02037 1 0 0 0 0 0 PF03810 0 1 0 0 0 0 PF03810 PF02985 1 0 0 0 0 0 PF03835 PF10403 PF10404 PF10405 PF16045 1 0 0 0 0 0 PF03876 0 1 1 0 0 0 PF03896 PF04511 1 0 0 0 0 0 PF04000 PF01583 PF14306 PF01747 1 0 0 0 0 0 PF04212 0 1 1 0 0 0 PF04757 PF00097 1 0 0 0 0 0 PF04757 PF13920 1 0 0 0 0 0 PF04889 PF00688 PF00019 1 0 0 0 0 0 PF05347 PF00472 1 0 0 0 0 0 PF05378 PF01968 PF02538 PF02271 1 0 0 0 0 0 PF05485 PF00378 1 0 0 0 0 0 PF05741 PF00089 1 0 0 0 0 0 PF05794 PF00102 1 0 0 0 0 0 PF05903 PF00916 PF01740 1 0 0 0 0 0 PF05978 PF07690 1 0 0 0 0 0 PF06031 PF07714 1 0 0 0 0 0 PF06374 0 0 0 0 1 0 PF06482 0 1 0 0 0 0 PF06664 PF02229 1 0 0 0 0 0 PF07156 0 0 1 0 0 0 PF07225 0 0 0 0 1 0 PF07304 PF00063 PF16521 1 0 0 0 0 0 PF07393 0 1 0 0 0 0 PF07651 PF01799 PF00941 PF03450 PF01315 PF02738 1 0 0 0 0 0 PF07657 PF01414 PF00008 0 0 2 0 0 0 PF07686 PF08205 PF13927 PF00501 PF13193 1 0 0 0 0 0 PF07686 PF13927 PF07679 PF13927 PF00041 1 0 0 0 0 0 PF07690 PF00083 1 0 0 0 0 0 PF07776 PF10497 1 0 0 0 0 0 PF07776 PF12874 PF13894 1 0 0 0 0 0 PF07776 PF12874 PF13912 PF13894 1 0 0 0 0 0 PF07776 PF13894 PF12874 1 0 0 0 0 0 PF07776 PF13894 PF12874 PF13912 1 0 0 0 0 0 PF07776 PF13894 PF13912 PF00096 1 0 0 0 0 0 PF07776 PF13912 PF12874 PF00096 1 0 0 0 0 0 PF07885 PF00179 1 0 0 0 0 0 PF07885 PF07776 PF13912 1 0 0 0 0 0 PF07993 PF03015 PF04515 1 0 0 0 0 0 PF07993 PF03015 PF07993 1 0 0 0 0 0 PF08159 PF00628 1 0 0 0 0 0 PF08205 PF07679 1 0 0 0 0 0 PF08318 0 1 0 0 0 0 PF08366 PF00400 1 0 0 0 0 0 PF08385 PF08393 0 1 5 0 0 0 PF08449 PF01699 1 0 0 0 0 0 PF08513 PF00400 PF05821 1 0 0 0 0 0 PF08676 0 1 0 0 0 0 PF08768 0 0 0 0 1 0 PF09177 0 0 0 0 1 0 PF09271 PF09270 PF09271 PF09270 1 0 0 0 0 0 PF09412 PF00676 PF02779 PF16870 1 0 0 0 0 0 PF09469 0 0 0 0 1 0 PF09813 PF00398 1 0 0 0 0 0 PF10479 PF01391 1 0 0 0 0 0 PF10487 0 0 0 0 1 0 PF10513 PF13831 PF13832 PF08569 1 0 0 0 0 0 PF10587 PF00736 PF05497 1 0 0 0 0 0 PF10609 PF02195 1 0 0 0 0 0 PF10613 PF00060 PF10613 PF00060 1 0 0 0 0 0 PF11326 PF00481 1 0 0 0 0 0 PF11817 0 0 2 0 0 0 PF12171 PF03828 1 0 0 0 0 0 PF12394 PF05057 PF00106 1 0 0 0 0 0 PF12422 0 0 0 0 1 0 PF12456 PF00094 PF08742 PF01826 PF00094 PF08742 PF01826 PF00094 PF08742 PF00754 PF00094 PF08742 PF01826 PF00094 PF08742 PF01826 1 0 0 0 0 0 PF12624 PF16908 0 0 7 0 0 0 PF12756 PF13912 1 0 0 0 0 0 PF12763 PF14604 PF07653 PF14604 1 0 0 0 0 0 PF12774 PF07728 PF12775 PF12780 PF12777 PF12781 PF03028 0 1 0 0 0 0 PF12796 PF00023 PF07724 PF10431 1 0 0 0 0 0 PF12796 PF00023 PF12796 PF00520 1 0 0 0 0 0 PF12796 PF02807 PF00217 1 0 0 0 0 0 PF12796 PF08344 0 1 0 0 0 0 PF12796 PF13637 PF00023 1 0 0 0 0 0 PF12874 PF00096 PF12874 PF00096 PF12874 PF13912 PF13894 PF01248 1 0 0 0 0 0 PF13202 PF13499 PF13202 1 0 0 0 0 0 PF13202 PF13833 PF13202 1 0 0 0 0 0 PF13270 0 0 0 0 1 0 PF13306 PF13855 PF00560 PF13855 PF01582 1 0 0 0 0 0 PF13405 PF00036 PF02100 1 0 0 0 0 0 PF13414 0 0 12 0 0 0 PF13499 PF13833 PF12352 1 0 0 0 0 0 PF13513 0 1 0 0 0 0 PF13516 PF06094 1 0 0 0 0 0 PF13537 PF00733 PF14786 1 0 0 0 0 0 PF13589 PF01119 0 1 1 0 0 0 PF13599 0 1 0 0 0 0 PF13637 PF01753 1 0 0 0 0 0 PF13833 PF13202 PF13833 1 0 0 0 0 0 PF13848 0 1 0 0 0 0 PF13855 PF00560 PF07679 1 0 0 0 0 0 PF13855 PF13516 PF01582 1 0 0 0 0 0 PF13855 PF15998 1 0 0 0 0 0 PF13855 PF16878 PF00046 1 0 0 0 0 0 PF13904 0 0 0 0 1 0 PF13913 PF00096 PF13913 1 0 0 0 0 0 PF13927 0 1 0 0 0 0 PF13927 PF00834 1 0 0 0 0 0 PF13927 PF01582 1 0 0 0 0 0 PF13927 PF08205 PF13927 1 0 0 0 0 0 PF14529 0 0 0 0 1 0 PF14545 PF00095 1 0 0 0 0 0 PF14774 0 0 0 0 1 0 PF14846 0 0 0 0 1 0 PF14912 PF00135 1 0 0 0 0 0 PF15309 PF00685 1 0 0 0 0 0 PF15619 0 0 0 0 1 0 PF15862 PF00001 1 0 0 0 0 0 PF15888 0 0 0 0 1 0 PF15914 0 0 0 0 1 0 PF16040 PF16041 PF00010 1 0 0 0 0 0 PF16066 PF00083 1 0 0 0 0 0 PF16211 0 1 0 0 0 0 PF16685 0 0 1 0 0 0 PF16770 0 0 3 0 0 0