GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0003676	nucleic acid binding	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0003677	DNA binding	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0097159	organic cyclic compound binding	Gains
GO:1901363	heterocyclic compound binding	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
GO:0097747	RNA polymerase activity	Gains
GO:0034062	5'-3' RNA polymerase activity	Gains
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
GO:0005549	odorant binding	Gains
GO:0032934	sterol binding	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0003682	chromatin binding	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0038023	signaling receptor activity	Gains
GO:0005496	steroid binding	Gains
GO:0033868	Goodpasture-antigen-binding protein kinase activity	Gains
GO:0046974	histone methyltransferase activity (H3-K9 specific)	Gains
GO:0003810	protein-glutamine gamma-glutamyltransferase activity	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0016651	oxidoreductase activity, acting on NAD(P)H	Gains
GO:0042302	structural constituent of cuticle	Gains
GO:0004872	receptor activity	Gains
GO:0004776	succinate-CoA ligase (GDP-forming) activity	Gains
GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity	Gains
GO:0004832	valine-tRNA ligase activity	Gains
GO:0035586	purinergic receptor activity	Gains
GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity	Gains
GO:0008449	N-acetylglucosamine-6-sulfatase activity	Gains
GO:0004370	glycerol kinase activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0016408	C-acyltransferase activity	Gains
GO:0015085	calcium ion transmembrane transporter activity	Gains
GO:0022892	substrate-specific transporter activity	Gains
GO:0099094	ligand-gated cation channel activity	Gains
GO:0004687	myosin light chain kinase activity	Gains
GO:0004619	phosphoglycerate mutase activity	Gains
GO:0004012	phospholipid-translocating ATPase activity	Gains
GO:0043178	alcohol binding	Gains
GO:0015171	amino acid transmembrane transporter activity	Gains
GO:0005215	transporter activity	Gains
GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
GO:0008010	structural constituent of chitin-based larval cuticle	Gains
GO:0004983	neuropeptide Y receptor activity	Gains
GO:0046914	transition metal ion binding	Gains
GO:0005319	lipid transporter activity	Gains
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Gains
GO:0008270	zinc ion binding	Gains
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0140097	catalytic activity, acting on DNA	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0005212	structural constituent of eye lens	Losses
GO:0046423	allene-oxide cyclase activity	Losses
GO:0047396	glycosylphosphatidylinositol diacylglycerol-lyase activity	Losses
GO:0051213	dioxygenase activity	Losses
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Losses
GO:0008812	choline dehydrogenase activity	Losses
GO:0005000	vasopressin receptor activity	Losses
GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	Losses
GO:0004185	serine-type carboxypeptidase activity	Losses
GO:0015631	tubulin binding	Losses
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
GO:0070008	serine-type exopeptidase activity	Losses
GO:0004658	propionyl-CoA carboxylase activity	Losses
GO:0070717	poly-purine tract binding	Losses
GO:0019894	kinesin binding	Losses
GO:0008430	selenium binding	Losses
GO:0008143	poly(A) binding	Losses
GO:0004181	metallocarboxypeptidase activity	Losses
GO:0008017	microtubule binding	Losses
GO:0004180	carboxypeptidase activity	Losses
GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	Losses
GO:0004322	ferroxidase activity	Losses
GO:0016597	amino acid binding	Losses
GO:0015179	L-amino acid transmembrane transporter activity	Losses
GO:0022891	substrate-specific transmembrane transporter activity	Losses
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0140097	catalytic activity, acting on DNA	Extinctions
GO:0051213	dioxygenase activity	Extinctions
GO:0034061	DNA polymerase activity	Extinctions
GO:0046423	allene-oxide cyclase activity	Extinctions
GO:0047396	glycosylphosphatidylinositol diacylglycerol-lyase activity	Extinctions
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Extinctions
GO:0016779	nucleotidyltransferase activity	Extinctions
GO:0008812	choline dehydrogenase activity	Extinctions
GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	Extinctions
GO:0004658	propionyl-CoA carboxylase activity	Extinctions
GO:0070717	poly-purine tract binding	Extinctions
GO:0019894	kinesin binding	Extinctions
GO:0008430	selenium binding	Extinctions
GO:0008143	poly(A) binding	Extinctions
GO:0016597	amino acid binding	Extinctions
GO:0003678	DNA helicase activity	Extinctions
GO:0015631	tubulin binding	Extinctions
GO:0008066	glutamate receptor activity	Extinctions
GO:0140104	molecular carrier activity	Extinctions
GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Extinctions
GO:0031406	carboxylic acid binding	Extinctions
GO:0043177	organic acid binding	Extinctions
GO:0016277	[myelin basic protein]-arginine N-methyltransferase activity	Extinctions
GO:0050700	CARD domain binding	Extinctions
GO:0008531	riboflavin kinase activity	Extinctions
GO:0016595	glutamate binding	Extinctions
GO:0035226	glutamate-cysteine ligase catalytic subunit binding	Extinctions
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Extinctions
GO:0050577	GDP-L-fucose synthase activity	Extinctions
GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Extinctions
GO:0004566	beta-glucuronidase activity	Extinctions
GO:0004567	beta-mannosidase activity	Extinctions
GO:0035755	cardiolipin hydrolase activity	Extinctions
GO:0033677	DNA/RNA helicase activity	Extinctions
GO:0031177	phosphopantetheine binding	Extinctions
GO:0003920	GMP reductase activity	Extinctions
GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	Extinctions
GO:0044620	ACP phosphopantetheine attachment site binding	Extinctions
GO:0047444	N-acylneuraminate-9-phosphate synthase activity	Extinctions
GO:0001642	group III metabotropic glutamate receptor activity	Extinctions
GO:0033981	D-dopachrome decarboxylase activity	Extinctions
GO:0070576	vitamin D 24-hydroxylase activity	Extinctions
GO:0000036	acyl carrier activity	Extinctions
GO:0051192	prosthetic group binding	Extinctions
GO:0050462	N-acetylneuraminate synthase activity	Extinctions
GO:0070611	histone methyltransferase activity (H3-R2 specific)	Extinctions
GO:0034986	iron chaperone activity	Extinctions
GO:0004411	homogentisate 1,2-dioxygenase activity	Extinctions
GO:0045294	alpha-catenin binding	Extinctions
GO:0008780	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity	Extinctions
GO:0008743	L-threonine 3-dehydrogenase activity	Extinctions