GO:0004984	olfactory receptor activity	Gains
GO:0008066	glutamate receptor activity	Gains
GO:0005549	odorant binding	Gains
GO:0001637	G-protein coupled chemoattractant receptor activity	Gains
GO:0004950	chemokine receptor activity	Gains
GO:0004970	ionotropic glutamate receptor activity	Gains
GO:0022824	transmitter-gated ion channel activity	Gains
GO:0022835	transmitter-gated channel activity	Gains
GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
GO:0005230	extracellular ligand-gated ion channel activity	Gains
GO:0015267	channel activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
GO:0005216	ion channel activity	Gains
GO:0004896	cytokine receptor activity	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0016215	acyl-CoA desaturase activity	Gains
GO:0004768	stearoyl-CoA 9-desaturase activity	Gains
GO:0015276	ligand-gated ion channel activity	Gains
GO:0022834	ligand-gated channel activity	Gains
GO:0004129	cytochrome-c oxidase activity	Gains
GO:0015002	heme-copper terminal oxidase activity	Gains
GO:0016675	oxidoreductase activity, acting on a heme group of donors	Gains
GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Gains
GO:0004872	receptor activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0030594	neurotransmitter receptor activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0140097	catalytic activity, acting on DNA	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0004190	aspartic-type endopeptidase activity	Losses
GO:0070001	aspartic-type peptidase activity	Losses
GO:0004519	endonuclease activity	Losses
GO:0046914	transition metal ion binding	Losses
GO:0042834	peptidoglycan binding	Losses
GO:0008010	structural constituent of chitin-based larval cuticle	Losses
GO:0004872	receptor activity	Losses
GO:0043169	cation binding	Losses
GO:0004175	endopeptidase activity	Losses
GO:0046872	metal ion binding	Losses
GO:0008270	zinc ion binding	Losses
GO:0004518	nuclease activity	Losses
GO:0038023	signaling receptor activity	Losses
GO:0042302	structural constituent of cuticle	Losses
GO:0016787	hydrolase activity	Losses
GO:0060089	molecular transducer activity	Losses
GO:0004435	phosphatidylinositol phospholipase C activity	Losses
GO:0004629	phospholipase C activity	Losses
GO:0005214	structural constituent of chitin-based cuticle	Losses
GO:0003676	nucleic acid binding	Losses
GO:0016788	hydrolase activity, acting on ester bonds	Losses
GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
GO:0004871	signal transducer activity	Losses
GO:0008233	peptidase activity	Losses
GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
GO:0005549	odorant binding	Losses
GO:0003723	RNA binding	Losses
GO:0099600	transmembrane receptor activity	Losses
GO:0005539	glycosaminoglycan binding	Losses
GO:0004521	endoribonuclease activity	Losses
GO:0001530	lipopolysaccharide binding	Losses
GO:0008329	signaling pattern recognition receptor activity	Losses
GO:0038187	pattern recognition receptor activity	Losses
GO:0003990	acetylcholinesterase activity	Losses
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Losses
GO:0004888	transmembrane signaling receptor activity	Losses
GO:0004104	cholinesterase activity	Losses
GO:0004803	transposase activity	Losses
GO:0003678	DNA helicase activity	Losses
GO:0008527	taste receptor activity	Losses
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Losses
GO:0009881	photoreceptor activity	Losses
GO:0009378	four-way junction helicase activity	Losses
GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Losses
GO:0016531	copper chaperone activity	Losses
GO:0001872	(1->3)-beta-D-glucan binding	Losses
GO:0003913	DNA photolyase activity	Losses
GO:0003904	deoxyribodipyrimidine photo-lyase activity	Losses
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
GO:0004930	G-protein coupled receptor activity	Losses
GO:0019840	isoprenoid binding	Losses
GO:0016755	transferase activity, transferring amino-acyl groups	Losses
GO:0003677	DNA binding	Losses
GO:0016829	lyase activity	Losses
GO:0042910	xenobiotic transmembrane transporter activity	Losses
GO:0005272	sodium channel activity	Losses
GO:0005506	iron ion binding	Losses
GO:0046592	polyamine oxidase activity	Losses
GO:0070891	lipoteichoic acid binding	Losses
GO:0030882	lipid antigen binding	Losses
GO:0003810	protein-glutamine gamma-glutamyltransferase activity	Losses
GO:0035197	siRNA binding	Losses
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Losses
GO:0016530	metallochaperone activity	Losses
GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Losses
GO:0004089	carbonate dehydratase activity	Losses
GO:0004386	helicase activity	Losses
GO:0030246	carbohydrate binding	Losses
GO:0016836	hydro-lyase activity	Losses
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
GO:0003713	transcription coactivator activity	Losses
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
GO:0016917	GABA receptor activity	Losses
GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	Losses
GO:0003823	antigen binding	Losses
GO:0043548	phosphatidylinositol 3-kinase binding	Losses
GO:0004736	pyruvate carboxylase activity	Losses
GO:0005501	retinoid binding	Losses
GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Losses
GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
GO:0004540	ribonuclease activity	Losses
GO:0004984	olfactory receptor activity	Losses
GO:1901363	heterocyclic compound binding	Losses
GO:0004620	phospholipase activity	Losses
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0034061	DNA polymerase activity	Extinctions
GO:0140097	catalytic activity, acting on DNA	Extinctions
GO:0016779	nucleotidyltransferase activity	Extinctions
GO:0004190	aspartic-type endopeptidase activity	Extinctions
GO:0070001	aspartic-type peptidase activity	Extinctions
GO:0003676	nucleic acid binding	Extinctions
GO:0046914	transition metal ion binding	Extinctions
GO:0008270	zinc ion binding	Extinctions
GO:0043169	cation binding	Extinctions
GO:0042834	peptidoglycan binding	Extinctions
GO:0046872	metal ion binding	Extinctions
GO:0004175	endopeptidase activity	Extinctions
GO:0003677	DNA binding	Extinctions
GO:0003678	DNA helicase activity	Extinctions
GO:0003723	RNA binding	Extinctions
GO:0001530	lipopolysaccharide binding	Extinctions
GO:0004803	transposase activity	Extinctions
GO:0004519	endonuclease activity	Extinctions
GO:0009378	four-way junction helicase activity	Extinctions
GO:0016531	copper chaperone activity	Extinctions
GO:0004518	nuclease activity	Extinctions
GO:0005272	sodium channel activity	Extinctions
GO:0004386	helicase activity	Extinctions
GO:0070891	lipoteichoic acid binding	Extinctions
GO:0030882	lipid antigen binding	Extinctions
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Extinctions
GO:0016530	metallochaperone activity	Extinctions
GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Extinctions
GO:0016787	hydrolase activity	Extinctions
GO:0008233	peptidase activity	Extinctions
GO:1901363	heterocyclic compound binding	Extinctions
GO:0097159	organic cyclic compound binding	Extinctions
GO:0004435	phosphatidylinositol phospholipase C activity	Extinctions
GO:0004629	phospholipase C activity	Extinctions
GO:0003823	antigen binding	Extinctions
GO:0004736	pyruvate carboxylase activity	Extinctions
GO:0005501	retinoid binding	Extinctions
GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
GO:0070011	peptidase activity, acting on L-amino acid peptides	Extinctions
GO:0005549	odorant binding	Extinctions
GO:0008527	taste receptor activity	Extinctions
GO:0004784	superoxide dismutase activity	Extinctions
GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Extinctions
GO:0009008	DNA-methyltransferase activity	Extinctions
GO:0003713	transcription coactivator activity	Extinctions
GO:0005506	iron ion binding	Extinctions
GO:0005539	glycosaminoglycan binding	Extinctions
GO:0016788	hydrolase activity, acting on ester bonds	Extinctions