GO:0005549	odorant binding	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0038023	signaling receptor activity	Gains
GO:0004872	receptor activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0008527	taste receptor activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0022824	transmitter-gated ion channel activity	Gains
GO:0022835	transmitter-gated channel activity	Gains
GO:0004970	ionotropic glutamate receptor activity	Gains
GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
GO:0008066	glutamate receptor activity	Gains
GO:0015276	ligand-gated ion channel activity	Gains
GO:0022834	ligand-gated channel activity	Gains
GO:0030594	neurotransmitter receptor activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0005216	ion channel activity	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0005230	extracellular ligand-gated ion channel activity	Gains
GO:0015267	channel activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0022836	gated channel activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0015075	ion transmembrane transporter activity	Gains
GO:0022891	substrate-specific transmembrane transporter activity	Gains
GO:0022857	transmembrane transporter activity	Gains
GO:0022892	substrate-specific transporter activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0005550	pheromone binding	Gains
GO:0005272	sodium channel activity	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0036081	extracellular ammonia-gated ion channel activity	Gains
GO:0005215	transporter activity	Gains
GO:0005261	cation channel activity	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0033041	sweet taste receptor activity	Gains
GO:0046873	metal ion transmembrane transporter activity	Gains
GO:0003950	NAD+ ADP-ribosyltransferase activity	Gains
GO:0048027	mRNA 5'-UTR binding	Gains
GO:0003676	nucleic acid binding	Gains
GO:0008061	chitin binding	Gains
GO:0043141	ATP-dependent 5'-3' DNA helicase activity	Gains
GO:0003810	protein-glutamine gamma-glutamyltransferase activity	Gains
GO:0005158	insulin receptor binding	Gains
GO:0004768	stearoyl-CoA 9-desaturase activity	Gains
GO:0016215	acyl-CoA desaturase activity	Gains
GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
GO:0022890	inorganic cation transmembrane transporter activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0140097	catalytic activity, acting on DNA	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0003677	DNA binding	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0004190	aspartic-type endopeptidase activity	Losses
GO:0070001	aspartic-type peptidase activity	Losses
GO:0046872	metal ion binding	Losses
GO:0043169	cation binding	Losses
GO:0003700	DNA binding transcription factor activity	Losses
GO:0003676	nucleic acid binding	Losses
GO:0009881	photoreceptor activity	Losses
GO:0005214	structural constituent of chitin-based cuticle	Losses
GO:0140110	transcription regulator activity	Losses
GO:0008201	heparin binding	Losses
GO:0008010	structural constituent of chitin-based larval cuticle	Losses
GO:0003690	double-stranded DNA binding	Losses
GO:0046914	transition metal ion binding	Losses
GO:0008270	zinc ion binding	Losses
GO:0004803	transposase activity	Losses
GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
GO:0003913	DNA photolyase activity	Losses
GO:0003904	deoxyribodipyrimidine photo-lyase activity	Losses
GO:0008020	G-protein coupled photoreceptor activity	Losses
GO:0050591	quinine 3-monooxygenase activity	Losses
GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
GO:0004470	malic enzyme activity	Losses
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	Losses
GO:0043565	sequence-specific DNA binding	Losses
GO:1901363	heterocyclic compound binding	Losses
GO:0005539	glycosaminoglycan binding	Losses
GO:0097159	organic cyclic compound binding	Losses
GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
GO:0005488	binding	Losses
GO:0003707	steroid hormone receptor activity	Losses
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
GO:0003990	acetylcholinesterase activity	Losses
GO:0019992	diacylglycerol binding	Losses
GO:0008061	chitin binding	Losses
GO:0044212	transcription regulatory region DNA binding	Losses
GO:1901681	sulfur compound binding	Losses
GO:0000975	regulatory region DNA binding	Losses
GO:0001067	regulatory region nucleic acid binding	Losses
GO:0004518	nuclease activity	Losses
GO:0060089	molecular transducer activity	Losses
GO:0008301	DNA binding, bending	Losses
GO:0004104	cholinesterase activity	Losses
GO:0004364	glutathione transferase activity	Losses
GO:0004872	receptor activity	Losses
GO:0004879	nuclear receptor activity	Losses
GO:0098531	transcription factor activity, direct ligand regulated sequence-specific DNA binding	Losses
GO:0097747	RNA polymerase activity	Losses
GO:0034062	5'-3' RNA polymerase activity	Losses
GO:0019238	cyclohydrolase activity	Losses
GO:0016406	carnitine O-acyltransferase activity	Losses
GO:0009008	DNA-methyltransferase activity	Losses
GO:0015368	calcium:cation antiporter activity	Losses
GO:0043167	ion binding	Losses
GO:0004175	endopeptidase activity	Losses
GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
GO:0099094	ligand-gated cation channel activity	Losses
GO:0030247	polysaccharide binding	Losses
GO:0001871	pattern binding	Losses
GO:0099516	ion antiporter activity	Losses
GO:0016769	transferase activity, transferring nitrogenous groups	Losses
GO:0008483	transaminase activity	Losses
GO:0016615	malate dehydrogenase activity	Losses
GO:0008307	structural constituent of muscle	Losses
GO:0000976	transcription regulatory region sequence-specific DNA binding	Losses
GO:0015297	antiporter activity	Losses
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
GO:0005509	calcium ion binding	Losses
GO:0003677	DNA binding	Extinctions
GO:0003676	nucleic acid binding	Extinctions
GO:0140097	catalytic activity, acting on DNA	Extinctions
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0034061	DNA polymerase activity	Extinctions
GO:0016779	nucleotidyltransferase activity	Extinctions
GO:0003690	double-stranded DNA binding	Extinctions
GO:0003700	DNA binding transcription factor activity	Extinctions
GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Extinctions
GO:0004803	transposase activity	Extinctions
GO:0140110	transcription regulator activity	Extinctions
GO:0004190	aspartic-type endopeptidase activity	Extinctions
GO:0070001	aspartic-type peptidase activity	Extinctions
GO:0046872	metal ion binding	Extinctions
GO:0016406	carnitine O-acyltransferase activity	Extinctions
GO:0043169	cation binding	Extinctions
GO:0008201	heparin binding	Extinctions
GO:0044212	transcription regulatory region DNA binding	Extinctions
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Extinctions
GO:0000975	regulatory region DNA binding	Extinctions
GO:0001067	regulatory region nucleic acid binding	Extinctions
GO:0043565	sequence-specific DNA binding	Extinctions
GO:0008061	chitin binding	Extinctions
GO:0004518	nuclease activity	Extinctions
GO:1901363	heterocyclic compound binding	Extinctions
GO:0046914	transition metal ion binding	Extinctions
GO:0097159	organic cyclic compound binding	Extinctions
GO:0097747	RNA polymerase activity	Extinctions
GO:0034062	5'-3' RNA polymerase activity	Extinctions
GO:0008301	DNA binding, bending	Extinctions
GO:0000976	transcription regulatory region sequence-specific DNA binding	Extinctions
GO:0008270	zinc ion binding	Extinctions
GO:0005214	structural constituent of chitin-based cuticle	Extinctions
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Extinctions
GO:0033608	formyl-CoA transferase activity	Extinctions
GO:0042586	peptide deformylase activity	Extinctions
GO:0043295	glutathione binding	Extinctions
GO:0047749	cholestanetriol 26-monooxygenase activity	Extinctions
GO:0015280	ligand-gated sodium channel activity	Extinctions
GO:0051908	double-stranded DNA 5'-3' exodeoxyribonuclease activity	Extinctions
GO:0005104	fibroblast growth factor receptor binding	Extinctions
GO:0008815	citrate (pro-3S)-lyase activity	Extinctions
GO:0008816	citryl-CoA lyase activity	Extinctions
GO:0016414	O-octanoyltransferase activity	Extinctions
GO:0047536	2-aminoadipate transaminase activity	Extinctions
GO:0004846	urate oxidase activity	Extinctions
GO:0047617	acyl-CoA hydrolase activity	Extinctions
GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity	Extinctions
GO:0004507	steroid 11-beta-monooxygenase activity	Extinctions
GO:0004666	prostaglandin-endoperoxide synthase activity	Extinctions
GO:0044736	acid-sensing ion channel activity	Extinctions
GO:0004092	carnitine O-acetyltransferase activity	Extinctions
GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Extinctions
GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Extinctions
GO:0008458	carnitine O-octanoyltransferase activity	Extinctions
GO:0046875	ephrin receptor binding	Extinctions
GO:0008473	ornithine cyclodeaminase activity	Extinctions
GO:0008477	purine nucleosidase activity	Extinctions
GO:0008196	vitellogenin receptor activity	Extinctions
GO:0003720	telomerase activity	Extinctions
GO:0003721	telomerase RNA reverse transcriptase activity	Extinctions
GO:1900750	oligopeptide binding	Extinctions
GO:1990837	sequence-specific double-stranded DNA binding	Extinctions
GO:0016769	transferase activity, transferring nitrogenous groups	Extinctions
GO:0008483	transaminase activity	Extinctions
GO:1901681	sulfur compound binding	Extinctions
GO:0005509	calcium ion binding	Extinctions